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Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

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Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review antioxidants Review Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review Meenakshi Sharma 1, Inderpreet Dhaliwal 2, Kusum Rana 3 , Anil Kumar Delta 1 and Prashant Kaushik 4,5,* 1 Department of Chemistry, Ranchi University, Ranchi 834001, India; [email protected] (M.S.); [email protected] (A.K.D.) 2 Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana 141004, India; [email protected] 3 Department of Biotechnology, Panjab University, Sector 25, Chandigarh 160014, India; [email protected] 4 Kikugawa Research Station, Yokohama Ueki, 2265 Kamo, Kikugawa City 439-0031, Japan 5 Instituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, 46022 Valencia, Spain * Correspondence: [email protected] or [email protected] Abstract: Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Citation: Sharma, M.; Dhaliwal, I.; Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and Rana, K.; Delta, A.K.; Kaushik, P. phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and Phytochemistry, Pharmacology, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological Toxicology of Datura Species—A effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse Antioxidants 10 Review. 2021, , 1291. of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes neces- https://doi.org/10.3390/antiox1008 sary to be aware of the toxic aspects and the potential risks accompanying its use. The present review 1291 aims to summarize the phytochemical composition and pharmacological and toxicological aspects of Datura Academic Editors: Filomena Nazzaro the plant . and Vincenzo De Feo Keywords: Datura stramonium; alkaloids; atropine; cardiac glycosides; hyoscamine; Ayurveda Received: 29 July 2021 Accepted: 13 August 2021 Published: 15 August 2021 1. Introduction Publisher’s Note: MDPI stays neutral Medicinal plants present a wide range of bioactive substances known for their pharma- with regard to jurisdictional claims in cological activities. In fact, the majority of conventional medicines rely on plant products. published maps and institutional affil- One such plant species is Datura spp., a flowering medicinal herb that pertains to the iations. Solanaceae family [1], primarily used as an intoxicant and hallucinogen [2]. It is widely culti- vated in Europe, Asia, America, South Africa, and other tropical and subtropical regions [3]. Datura can be well-grown in average soils, but it prefers nutrient-rich and moist soil or alkaline soil [4]. Although the plant acts as a narcotic, it has distinct effects on human health, Copyright: © 2021 by the authors. rendering it incredibly beneficial as medicine [5,6]. This may be attributed to the fact that it Licensee MDPI, Basel, Switzerland. possesses antimicrobial, antidiabetic, anti-asthmatic, anti-inflammatory, antioxidant, anal- This article is an open access article gesic, insecticidal, cytotoxic, wound healing, and neurological activities [7,8]. The Datura distributed under the terms and plant is also known for its larvicidal effects against red flour beetle (Tribolium castaneum) conditions of the Creative Commons and mosquito repellent activities [9,10]. In addition, Datura spp. has also been used Attribution (CC BY) license (https:// against animal bites such as snake bites, which helps relieve pain. D. stramonium, the creativecommons.org/licenses/by/ well-known species of this family, is utilized for mystic and religious purposes along with 4.0/). Antioxidants 2021, 10, 1291. https://doi.org/10.3390/antiox10081291 https://www.mdpi.com/journal/antioxidants Antioxidants 2021, 10, 1291 2 of 12 its use as herbal medicine [11]. Moreover, D. stramonium seed is generally smoked to get a hallucinogenic experience [3]. The consumption of any part of Datura plant may lead to the severe anticholinergic effect that may cause toxicity. In fact, the entire plant is toxic to some extent, but the seeds are found to be the most toxic; neither drying out nor boiling destroys the toxic prop- erties [12,13]. Ayurvedic system of medicine has described D. stramonium as a valuable therapy for numerous human illnesses such as wounds, ulcers, rheumatism, fever, in- flammation, asthma, and toothache [3,14]. A leaf extract taken orally can treat asthma along with sinus infection, and stripped bark can heal burns, swellings, and ulcers when applied externally to the affected area [9,15]. However, in the modern system of medicine, the therapeutic potentials of D. stramonium are dominated by its toxic effects. The intake of large doses of D. stramonium disturbs the central nervous system and produces symp- toms like confusion, hallucinations and amnesia, and bizarre behavior [16]. In addition, the signs and symptoms of acute D. stramonium poisoning include dryness of the lips and the epidermis, pupil dilation, urinary retention, impaired vision, and fast heartbeat [15,17]. Several incidences of accidental or intentional D. stramonium poisoning have been reported from different parts of the world, when eaten directly or through decoction made from herbal prescriptions, owing to its mind-affecting properties [18]. Therefore, the therapeutic applications require extensive research and analysis of the plant from every aspect, especially its toxicity. It should be consumed only with prior knowledge of its adverse effects since the consequences can be extremely harmful. With these facts, it is necessary to be aware of the toxic aspects and the potential risks accompanying its use. As a result, a systematic review of the literature was conducted using keywords: datura; datura phytoconstituents; atropine datura; using the Preferred Reporting Items for Systematic Meta-Analysis (PRISMA) approach [19]. The present review aims to sum- marize the phytochemical composition, pharmacological and toxicological aspects of the plant Datura. 2. Ethnobotanical Description of Datura The genus Datura is generally represented as annual or perennial herbs with glandular or more often simple hair [20]. Leaves of the plant are petiolate, having a simple leaf blade, and sinuate or completely dentate. They are approximately 10–20 cm in length and 5–18 cm in breadth, coated with soft and short greyish hairs [2]. The solitary flowers are found in inflorescences situated in leaf axils or branch forks. The larger flowers are generally actinomorphic with stout pedicels. The bracts, peduncles, and bracteoles are generally absent [20]. Further, the funnel-shaped and elongated corolla has cuspidate lobes. In many in- stances, elongated anthers are observed that are longitudinally dehiscing. The unevenly dehiscent, four valved fruit is discovered as a dry capsule that is unarmed and delimited usually by remnants of the persistent calyx [20]. The plants also consist of numerous seeds compressed laterally with a curved embryo and 12 pairs of chromosomes usually. Several species of Datura originated at different places globally. D. stramonium is an annual plant with an herbaceous base that is branched and glabrous, extending up to an approximate level of 1 m [13]. The branches are leafy, firm, erect, with pale yellow or green color, generally branched in a forked fashion. The top surface is greyish-green and dark, typically soft, while the lower surface is paler and minutely wrinkled when dehydrated. The calyx is very long, tubular, and swollen. The seeds are dark, flat, and kidney-shaped. Fruits are comparable to walnuts and filled with thorns (hence called “thorn apple”) [13]. 3. Biochemical Composition of Datura Datura, in general, constitutes significant amounts of carbohydrates, fats, protein, moisture, ash content, and crude fiber (Table1). Besides, major phytochemicals found in Datura include alkaloids, phenolic compounds, tannins, flavonoids, and cardiac glyco- sides [21,22]. In addition, many amino acids such as alanine, phenylalanine, glutamate, Antioxidants 2021, 10, 1291 3 of 12 and tyrosine have also been isolated from the seeds [8]. Datura species are particularly rich in tropane alkaloids. Hyoscine [(-)-Scopolamine] constitutes the major tropane alkaloid, along with hyoscyamine and atropine, having different concentration levels in different plant parts (Figure1)[ 11,23]. The atropine content in the leaves in Datura metel was found to be 0.426%, whereas hyoscyamine levels were found to be 0.426% in the seeds and 0.43% in flower [8]. The alkaloid contents of scopolamine and atropine in the entire plant in D. metel increase gradually with the development of various growth stages and becomes most apparent when the plant reaches the end of its reproductive stage [24,25]. However, in the case of D. stramonium, the maximum amounts of alkaloids were found after ten weeks
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