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Acute Kidney Injury Due to Menstruation-Related Disseminated Intravascular Coagulation in an Adenomyosis Patient: a Case Report

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Acute Kidney Injury Due to Menstruation-Related Disseminated Intravascular Coagulation in an Adenomyosis Patient: a Case Report CASE REPORT Nephrology DOI: 10.3346/jkms.2010.25.9.1372 • J Korean Med Sci 2010; 25: 1372-1374 Acute Kidney Injury due to Menstruation-related Disseminated Intravascular Coagulation in an Adenomyosis Patient: A Case Report Jungmin Son1,4, Dong Won Lee1,4, The authors report a case of acute kidney injury (AKI) resulting from menstruation-related Eun Young Seong1,4, Sang Heon Song1,4, disseminated intravascular coagulation (DIC) in an adenomyosis patient. A 40-yr-old Soo Bong Lee1,4, Jin Kang1, woman who had received gonadotropin for ovulation induction therapy presented with Byeong Yun Yang1, Su Jin Lee2,4, anuria and an elevated serum creatinine level. Her medical history showed primary 3,4 3,4 Jong-Ryeol Choi , Kyu-Sup Lee , infertility with diffuse adenomyosis. On admission, her pregnancy test was negative and 1,4 and Ihm Soo Kwak her menstrual cycle had started 1 day previously. Laboratory data were consistent with DIC, Department of Internal Medicine1, Division of and it was believed to be related to myometrial injury resulting from heavy intramyometrial Nephrology, Department of Internal Medicine2, menstrual flow. Gonadotropin is considered to play an important role in the development Division of Infectious Disease, Department of of fulminant DIC. This rare case suggests that physicians should be aware that gonadotropin Obstetrics and Gynecology3, Medical Research may provoke fulminant DIC in women with adenomyosis. Institute4, Pusan National University School of Medicine, Busan, Korea Key Words: Kidney Failure; Multiple Organ Failure; Disseminated Intravascular Coagulation; Received: 11 September 2009 Menstruation; Gonadotropins Accepted: 13 November 2009 Address for Correspondence: Dong Won Lee, M.D. Department of Internal Medicine, Division of Nephrology, Pusan National University School of Medicine, Beomeo-ri, Mulgeum-eup, Yangsan 626-770, Korea Tel: +82.55-360-1601, Fax: +82.55-360-1605 E-Mail: [email protected] INTRODUCTION with diffuse adenomyosis (Fig. 1) presented with anuria and an elevated serum creatinine (SCr) level at the Emergency Medi- Disseminated intravascular coagulation (DIC) is characterized cine Department on May 28, 2008. She had a history of two cycles by the systemic intravascular activation of coagulation (1). DIC of in vitro fertilization (IVF) at an infertility clinic, and the second can contribute to acute kidney injury (AKI) and other multior- cycle was performed 3 weeks prior to admission. Each cycle of gan failures due to the widespread deposition of fibrin in the IVF was treated with long protocol of gonadotropin-releasing circulation and the consequent compromise of blood supply to hormone (GnRH) agonist. For ovulation induction, daily 500 IU various organs. DIC is associated with various gyneco-obstetric of human menopausal gonadotropin was administered on men- conditions, such as, uterine leiomyoma and abruptio placenta. strual cycle days 3-15 and 5,000 IU of human chorionic gonad- However, DIC associated with adenomyosis is uncommon. A otropin (hCG) was administered on day 16, at 18 mm of leading literature review revealed only one report of DIC development follicles size. Ovum aspiration was performed at 36 hr after hCG during menstruation in an adenomyosis patient (2). However, injection. Five and nine oocytes were obtained at first and sec- in this previously reported case, AKI and other organ failures ond cycle, respectively. Daily 50 mg of progesterone and once were not observed. every three days 1,000 IU of hCG were administered for luteal We here present a case of AKI which resulting from menstru- support. The objective evidences of ovarian hyperstimulation ation-related DIC that was probably provoked by gonadotropin syndrome were not present on the day of ovum collection and administration. 7 days later. On admission, her blood urea nitrogen (BUN) level was 41.1 CASE REPORT mg/dL, and her SCr level was 3.5 md/dL. An examination of medical records revealed a baseline SCr level of 0.8 mg/dL, and A 40-yr-old woman who had experience of primary infertility a physical examination revealed an extremely enlarged uterus, © 2010 The Korean Academy of Medical Sciences. pISSN 1011-8934 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. eISSN 1598-6357 Son J, et al. • Menstruation-related Disseminated Intravascular Coagulation A B Fig. 2. Pathological findings of hysterectomized uterus. A( ) Gross appearance of ade- nomyosis. Note coarsely trabeculated, diffusely hypertrophied myometrium stippled with foci of ectopic endometrium. (B) Hematoxylin and eosin-stained section of uterus, showing endometrial glands and stroma surround ed by hypertrophied myometrium. Occasional hemosiderin-laden macrophages were also observed. Magnification, ×100. clonal component, and her computed tomographic renal scan Fig. 1. T2-weighted MRI scan showing extensive adenomyosis involvement. Low was unremarkable. signal intensity areas involving most of the uterus demonstrated diffuse thickening of Under a diagnosis of AKI resulting from unexplained DIC, the the junctional zone. Punctuate high signal foci represent islands of ectopic endometrial tissue or microhemorrhage (arrows). patient was treated with 0.9% sodium chloride solution, fresh frozen plasma, and platelet concentrates. However, despite treat- which was palpable at the level of the umbilicus. Her pregnancy ment, the patient required continuous renal replacement ther- test was negative and her menstrual cycle had started 1 day be- apy and therapeutic plasmapheresis due to progressive AKI and fore admission. Her vital signs were stable, and renal ultraso- multiorgan failures. The menstrual phase was terminated on the nography excluded an acute ureteral obstruction. fourth hospital day, and coagulation test findings then gradual- Laboratory testing showed the following: white blood cell ly improved. Her SCr level peaked on the 14th hospital day, and (WBC) count 30.07×109/L, hemoglobin level (Hb) 10.0 g/dL, reached a nadir of 1.1 mg/dL on 30th hospital day. The patient hematocrit (Hct) 29.6%, platelet count 39×109/L, lactate dehy- was treated with GnRH agonist for 3 months, and then under- drogenase (LDH) 7,914 IU/L, aspartate aminotransferase (AST) went hysterectomy on September 28, 2008. Pathological find- 329 IU/L, alanine aminotransferase (ALT) 92 IU/L, alkaline phos- ings confirmed diffuse adenomyosis (Fig. 2). phatase (ALP) 180 IU/L, total bilirubin 2.72 mg/dL, and cancer antigen 125 (CA125) 16,684 U/mL. A peripheral blood smear DISCUSSION revealed numerous schistocytes. A coagulation test revealed the characteristics of DIC (1). Her Adenomyosis is a benign gynecological condition that is char- laboratory values were as follows: prothrombin time (PT) 24.6 acterized by the presence of endometrial glands and stroma sec (normally 11.0 to 14.1 sec), prothrombin time-internation- within the myometrium (3). In adenomyosis patients, AKI is alized ratio (PT-INR) 2.25, activated partial thromboplastin time usually caused by obstructive uropathy. Furthermore, an uterus (aPTT) 58.2 sec (normally 30 to 44 sec), fibrinogen level 88 mg/ affected by adenomyosis can enlarge to that expected on the dL, D-dimer level 19.3 μg/mL, and antithrombin III level 74%. 12th gestational week. In addition, adenomyosis is frequently She had no known factor predisposing DIC, such as, infection associated with other uterine conditions, such as, leiomyoma or a malignancy. (35-55%) or pelvic endometriosis (5-20%). Thus, the differential Urinalysis revealed numerous red and white blood cells, but diagnosis of AKI should include obstructive uropathy, either her urine and blood cultures were negative. Serologies for anti- caused by adenomyosis per se or by coexisting conditions, such nuclear antibodies (ANA), antineutrophil cytoplasmic antibod- as, a bulky leiomyoma or ureteral endometriosis. ies (ANCA), cryoglobulins, hepatitis B surface antigen (HBsAg), In our case, renal ultrasonography excluded obstructive urop- anti-glomerular basement membrane antibodies (Anti-GBM), athy and laboratory data were consistent with AKI resulting from and antistreptococcal antibodies were all negative. Complement unexplained DIC. Accordingly, because she had no known fac- levels were within the normal range. Furthermore, both serum tor predisposing DIC, menstruation-related DIC was suspect- and urine protein electrophoresis failed to demonstrate a mono- ed. Nakamura et al. reported the first case of DIC development DOI: 10.3346/jkms.2010.25.9.1372 http://jkms.org 1373 Son J, et al. • Menstruation-related Disseminated Intravascular Coagulation during menstruation in an adenomyosis patient, and proposed menorrhagia, and dysmenorrhea. Infertility is a less frequent a myometrial injury mechanism (2). We agree that myometrial complaint because the majority of cases are diagnosed in their injury resulting from heavy intramyometrial menstrual flow fourth and fifth decades of life. However, because an increasing might activate the tissue factor coagulation pathway. However, number of women now postpone their first pregnancy until the fulminant DIC with AKI and other organ failures was not ob- late thirties, adenomyosis is being encountered more frequent- served in their case. ly in infertility clinics (10). We believe that gonadotropin played an
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