Revised April 2018
FACULTY VITA
Date: 4/1/19 Name: Ian Schneider Department: Chemical and Biological Engineering Current Rank: Associate Professor
I. BACKGROUND, PROFESSIONAL EXPERIENCE AND RECOGNITIONS
A. Education
North Carolina State University, PhD, Chemical Engineering, August 2005 North Carolina State University, MS, Chemical Engineering, December 2002 Iowa State University, BS, Chemical Engineering, May 2000
B. Academic Appointments
Associate Professor, Department of Chemical and Biological Engineering, Iowa State University, Ames, IA (2016-present) Associate Professor (Courtesy Appointment), Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA (2016-present) Assistant Professor, Department of Chemical and Biological Engineering, Iowa State University, Ames, IA (2009-2016) Assistant Professor (Courtesy Appointment), Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA (2009-2016)
C. Other Professional Employment
Senior Postdoctoral Research Associate, Dr. Sandra Schmid, the Scripps Research Institute, La Jolla, CA (October 2007 – December 2008) Damon Runyon Cancer Research Foundation Postdoctoral Fellow, Dr. Clare Waterman- Storer, the Scripps Research Institute, La Jolla, CA (July 2006 – December 2008) Postdoctoral Research Associate, Dr. Clare Waterman-Storer, the Scripps Research Institute, La Jolla, CA (October 2005 – September 2007)
D. Honors and Awards
Sigma Xi National Research Honor Society member (2011-present) Damon Runyon-Rachleff Innovation Award Semi-finalist (48/125) (2010) Damon Runyon Cancer Research Foundation Postdoctoral Research Fellow (2006-2008) Graduate Assistance in Areas of National Need (GAANN) Biotechnology Fellowship, North Carolina State (2000-2003) College of Engineering Dean’s Fellowship, North Carolina State (2000)
1 Revised April 2018
Sigma Xi National Research Honor Society associate member (2000-2011) Beisner Scholar Award winner, Iowa State University (1999) Tau Beta Pi National Engineering Honor Society member (1998)
II. SCHOLARSHIP AND RESEARCH/CREATIVE ACTIVITIES A. Scholarship # Denotes any publication derived from the candidate’s thesis/dissertation. * Denotes any publication not at ISU + Denotes student co-author. ǂ Denotes work after promotion to associate professor
1. Articles in Peer-Reviewed Journals – In Print or Accepted
ǂVeettil Unnikandam, SR, Bruggen Van, SM, Hwang, DG, Bartlett, MD, Schneider, IC, Tuning surface functionalization and collagen gel thickness to regulate cancer cell migration, Colloids and surfaces. B, Biointerfaces, 179, 37-47 (2019).
ǂWang, J, Boddupalli, A, Koelbl, J, Nam, DH, Ge, X, Bratlie, KM, Schneider, IC, Degradation and Remodeling of Epitaxially Grown Collagen Fibrils, Cellular and Molecular Bioengineering, 12, 69-84 (2019).
ǂ Senapati, S, Darling, R, Loh, D, Schneider, IC, Wannemuehler, MJ, Narasimhan, B, Mallapragada, SK, Pentablock copolymer micelle nanoadjuvants enhance cytosolic delivery of antigen and improve vaccine efficacy while inducing low inflammation (2019).
ǂWang, J, Koelbl, J, Boddupalli, A, Yao, Z, Bratlie, KM, Schneider, IC, Transfer of assembled collagen fibrils to flexible substrates for mechanically tunable contact guidance cues, Integrative Biology, 10, 705-718 (2018).
ǂNuhn, JAM, Gong, S, Che, X, Que, L, Schneider, IC, Microtissue size and cell-cell communication modulate cell migration in arrayed 3D collagen gels, Biomedical microdevices, 20, 62 (2018).
ǂChe, X, Boldrey, J, Zhong, X, Unnikandam-Veettil, S, Schneider, I, Jiles, D, Que, L, On- Chip Studies of Magnetic Stimulation Effect on Single Neural Cell Viability and Proliferation on Glass and Nanoporous Surfaces, ACS applied materials & interfaces, 10, 28269-28278 (2018).
ǂNuhn, JAM, Perez, AM and Schneider, IC, Contact guidance diversity in rotationally aligned collagen matrices, Acta Biomaterialia, 66, 248-257 (2018).
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ǂLee, KB, Nam DH, Nuhn, JAM, Wang, J, Schneider, IC and Ge, X, Direct Expression of Active Human Tissue Inhibitors of Metalloproteinases by Periplasmic Secretion in Escherichia coli, Microbial Cell Factories, 16, 73 (2017).
ǂWang J and Schneider IC, Myosin Phosphorylation on Stress Fibers Predicts Contact Guidance Behavior across Diverse Breast Cancer Cells, Biomaterials, 120, 81-93 (2017).
ǂChe, X, Nuhn, J, Schneider, IC and Que, L, High Throughput Studies of Cell Migration in 3D Microtissues Fabricated by a Droplet Microfluidic Chip, Micromachines, 7(5), 84 (2016).
Wang J, Petefish J, Hillier A, Schneider IC, Epitaxially Grown Collagen Fibers Reveal Diversity in Contact Guidance Behavior among Cancer Cells, Langmuir, 31, 307-344 (2015).
Hou Y, Lara Rodriguez L, Wang J and Schneider IC, Collagen Attachment to the Substrate Controls Cell Clustering through Migration, Phys. Biol., 11, 056007 (2014).
Haage A, Nam DH, Ge X and Schneider IC, Matrix Metalloproteinase-14 is a Mechanically Regulated Activator of Secreted MMPs and Invasion, Biochem. Biophys. Res. Commun., 450, 213-218 (2014).
Haage A and Schneider IC, Cellular Contractility and Extracellular Matrix Stiffness Regulate Matrix Metalloproteinase Activity in Pancreatic Cancer Cells, The FASEB J., 8, 3589-3599 (2014).
Romsey N, Hou Y, Lara Rodriguez L and Schneider IC, The Number of Lines a Cell Contacts and Cell Contractility Drive the Efficiency of Contact Guidance, Cell. Mol. Bioeng., 7, 122-135 (2014).
Lara Rodriguez L and Schneider IC, Directed Cell Migration in Multi-cue Environments, Integr. Biol., 5, 1306-1323 (2013).
Hou Y, Hedberg S and Schneider IC, Differences in adhesion and protrusion correlate with differences in migration speed under EGF Stimulation, BMC Biophysics, 5, 8 (2012).
Zhang Y, Haage A, Whitley EM, Schneider IC and Clapp AR, Mixed-surface, Lipid-tethered Quantum Dots for Targeting Cells and Tissues, Colloids Surf. B: Biointerfaces, 94, 27-35 (2012).
Gardel ML, Schneider IC, Aratyn-Schaus Y and Waterman C, Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration, Ann. Rev. of Cell and Dev. Biol., 26, 315- 333 (2010).
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Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD and Waterman C, Myosin II Activity Regulates Vinculin Recruitment to Focal Adhesions Through FAK-mediated Paxillin- phosphorylation, J. Cell Biol., 188, 877-890 (2010).
*Schneider IC, Hays CK and Waterman CM, EGF-induced Contraction Regulates Paxillin Phosphorylation to Temporally Separate Traction Generation from De-adhesion, Mol. Biol. Cell., 20, 3155-3167 (2009).
#*Haugh JM and Schneider IC, Effectiveness Factor for Spatial Gradient Sensing in Living Cells, Chem. Eng. Sci., 61, 5603-5611 (2006).
#*Schneider IC and Haugh JM, Mechanisms of Gradient Sensing and Chemotaxis: Conserved Pathways, Diverse Regulation, Cell Cycle, 5, 1130-1134 (2006).
#*Schneider IC and Haugh JM, Quantitative Elucidation of a Distinct Spatial Gradient Sensing Mechanism in Fibroblasts, J. Cell Biol., 171, 883-892 (2005).
#*Schneider IC, Parrish E, and Haugh JM, Spatial Analysis of 3’ Phosphoinositide Signaling in Living Fibroblasts: III. Influence of Cell Morphology and Morphological Polarity, Biophys. J., 89, 1420-1430 (2005).
#*Haugh JM, Schneider IC and Lewis JM, On the Cross-regulation of Protein Tyrosine Phosphatases and Receptor Tyrosine Kinases in Intracellular Signaling, J. Theor. Biol., 230, 119-132 (2004).
#*Schneider IC and Haugh JM, Spatial Analysis of 3’ Phosphoinositide Signaling in Living Fibroblasts: II. Parameter Estimates for Individual Cells from Experiments, Biophys. J., 86, 599-608 (2004).
#*Haugh JM and Schneider IC, Spatial Analysis of 3’ Phosphoinositide Signaling in Living Fibroblasts: I. Uniform Stimulation Model and Bounds on Dimensionless Groups, Biophys. J., 86, 589-598 (2004).
#*Park CS, Schneider IC and Haugh JM, Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts, J. Biol. Chem., 278, 37064-37072 (2003).
Schneider IC, Ames ML, Rasmussen MA and Reilly PJ, Fermentation of Cottonseed and Other Feedstuffs in Cattle Ruminal Contents, J. Agric. Food Chem., 50, 2267-2273 (2002).
Schneider IC, Rhamy PJ, Fink-Winter RJ and Reilly PJ, High-performance Anion-exchange Chromatography of Sugar and Glycerol Phosphates on Quaternary Ammonium Resins, Carbohydrate Research, 322, 128-134 (1999).
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2. Articles in Peer-Reviewed Journals – In Review n/a
3. Peer-Reviewed Conference Proceedings, Bulletins, or Reports – In Print/Accepted
Che, X, Nuhn, J, Schneider, IC and Que, L, A Nanostructure-Enabled Fluorescence Chip for Monitoring Cell Secretion, NANO: IEEE, 1-3 (2017).
Che X, Boldrey J, Zhong X, Schneider I, Jiles D and Que L. Studies of Single Neuron Cell Growth on Nanoporous Surface and under Transcranial Magnetic Stimulation, NANO: IEEE, 1-3 (2017).
Che, X, Nuhn, J, Schneider, IC and Que, L, Studies of cell behaviors in 3D microtissues in a microfluidic device: Growth and migration, Sensors: IEEE, 1-3 (2016).
4. Books and Book Chapters n/a
5. Formally Invited Seminars and Presentations
Controlling Collagen Mechanical and Structural Properties in Tumor Microenvironment Mimics, Biomedical Engineering Department, University of Minnesota, Minneapolis, 2019.
Controlling Collagen Structural and Mechanical Properties in Tumor Microenvironment Mimics, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, 2018.
Engineering Approaches for Understanding the Tumor Microenvironment, Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, 2015.
Engineering Approaches for Understanding Cancer Cell Interactions with the Tumor Microenvironment, SPORE/TMEN, University of Nebraska Medical Center, Omaha, 2014.
Engineering Approaches for Understanding Cancer Cell Interactions with the Tumor Microenvironment, Department of Chemical and Biological Engineering, Iowa State University, Ames, 2014.
Understanding Cell Migration Decisions in Multi-cue Environments, Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, 2014.
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Farming Tumors, Café Scientifique, Science Center of Iowa, Des Moines, 2014.
Understanding Cell Migration Decisions in Multi-cue Environments, Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, 2010.
Dynamic Organization of Subcellular Processes the Regulate Cell Migration, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, 2010.
Timing and Spatial Control of Epidermal Growth-factor Mediated Focal Adhesion Maturation and Cell Edge Dynamics, Engineering Cell Biology III, Santa Cruz, 2009.
*Dissecting Spatial and Temporal Processes Controlling Growth Factor-stimulated Cell Migration, Department of Chemical and Biomolecular Engineering, Notre Dame University, South Bend, 2008.
*Dissecting Spatial and Temporal Processes Controlling Growth Factor-stimulated Cell Migration, Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, 2008.
*Dissecting Spatial and Temporal Processes Controlling Growth Factor-stimulated Cell Migration, Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, 2008.
*Dissecting Spatial and Temporal Processes Controlling Growth Factor-stimulated Cell Migration, Department of Chemical and Biological Engineering, Iowa State University, Ames, 2008.
*#Spatial Sensing in Fibroblasts: Signaling Response to Platelet-derived Growth Factor Gradients, Department of Cell Biology, The Scripps Research Institute, San Diego, 2005.
*#Engineering Analysis of Platelet-derived Growth Factor-mediated Spatial Sensing in Fibroblasts, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, 2005.
6. Contributed Presentations
Case Studies As Vehicles for Enhancing Students’ Perceptions of the Broad Relevance of Biochemistry in Chemical Engineering. American Institute for Chemical Engineers Annual Fall Meeting, Pittsburgh, 2018.
Communication Between Pancreatic Cancer and Stellate Cells Modulates Contact Guidance, Matrix Metalloproteinase Activity and Reorganization of Aligned Collagen Networks. Biomedical Engineering Society Annual Fall Meeting, Atlanta, 2018.
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The role of Cancer Cell Force Transmission in Sensing Structural and Mechanical Features of Contact Guidance Cues. International Conference on Biomolecular Engineering, San Diego, 2017.
Cancer Cell Migration Decisions in Engineered Environments. American Institute for Chemical Engineers Annual Fall Meeting, Salt Lake City, 2015.
Cells Tune Matrix Metalloproteinase Activity By Sensing Mechanical Inputs. American Institute for Chemical Engineers Annual Fall Meeting, San Francisco, 2013.
Contact Guidance Differs on Micropatterned Collagen Substrates and Organized Collagen Fibers. American Institute for Chemical Engineers Annual Fall Meeting, Pittsburgh, 2012.
Regulation of focal adhesion maturation and cell edge dynamics by epidermal growth factor. American Institute for Chemical Engineers Annual Fall Meeting, Salt Lake City, 2010.
Timing and Spatial Control of Epidermal Growth Factor-mediated Focal Adhesion Maturation and Cell Edge Dynamics. American Institute for Chemical Engineers Annual Fall Meeting, Nashville, 2009.
EGF-Induced Contraction Temporally Separates Traction Generation from De-adhesion. American Institute for Chemical Engineers Annual Fall Meeting, Philadelphia, 2008.
*#A Divergent Mechanism of Spatial Gradient Sensing Revealed Through Quantitative Imaging and Modeling. American Society for Cell Biology Annual Meeting, San Francisco, 2005.
*Spatial Sensing in Fibroblasts: Distribution of 3’ PI Lipids in Response to Platelet- derived Growth Factor Gradients. American Institute of Chemical Engineers Annual Fall Meeting, Austin, 2004.
*#Imaging and Modeling of PDGF Receptor-mediated 3’ PI Lipid Dynamics in Living Cells. American Institute of Chemical Engineers Annual Fall Meeting, San Francisco, 2003.
*#Imaging and Spatial Analysis of Phosphoinositide 3-kianse Signaling in Living Fibroblasts. Mid-Atlantic Biochemical Engineering Consortium, College Park, 2003.
*#Imaging and Analysis of Phosphoinositide 3-kinase Signaling in Living Fibroblasts. American Institute of Chemical Engineers Annual Fall Meeting, Indianapolis, 2002.
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7. Other Scholarly Contributions
(Poster) Boldrey, J., Schneider, I., Que, L., and Jiles, D. The Influence of Magnetic Field Orientation on the Growth of Neurite Extensions of NGF Differentiated PC-12 Neuronal Cells, Minnesota Neuromodulation Symposium, 2019.
(Poster) Boldrey, J., Que, L., Schneider, I. and Jiles, D. The Influence of Magnetic Field Orientation on the Growth of Neurite Extensions of NGF Differentiated PC-12 Neuronal Cells, InterMag/MMM Conference, Washington DC, 2019.
(Poster) Boldrey, J., Zhong, X., Que, L., Schneider, I. and Jiles, D. The Influence of Pulsed Magnetic Fields on the Proliferation of Adherent and Non-Adherent Neuronal Cell Types, InterMag/MMM Conference, Washington DC, 2019.
(Oral) Lamm, M., Ausberger, A., Schneider, I. and Jarboe, L. Chemical Engineering Teaching Practicum Course: Reflections after Five Years, Pittsburgh, 2018.
(Poster) Rahman, S.M., Campbell, J.M., Schneider, I. and Melvin, A. A microfluidic Approach to Quantify Migration of Highly Invasive Cancer Cells. American Institute for Chemical Engineers Annual Fall Meeting, Pittsburgh, 2018.
(Poster) Rahman, S.M., Campbell, J.M., Schneider, I. and Melvin, A. Examine how oscillating patterns of chemical gradients break the spatial range limitations of conventional chemotaxis. American Chemical Society Annual Spring Meeting, New Orleans, 2018.
(Poster) Boldrey, J., Zhong, X., Que, L., Schneider, I. and Jiles, D. The Influence of Pulsed Magnetic Fields on NGF, Differentiated PC-12 Neuronal Cells, Minnesota Neuromodulation Symposium, 2018.
(Poster) Boldrey, J., Zhong, X., Que, L., Schneider, I. and Jiles, D. Effects of Magnetic Stimulation on the Proliferation of Dopaminergic Neuronal Cells Grown in Extracellular Matrix. Intermag, Singapore, 2018.
(Poster) Senapati, S., Loh, D., Wannemuehler, M.J., Narasimhan, B. and Mallapragada, S., Novel Pentablock Copolymer Micelle-based Nanoadjuvants. Society for Biomaterials Annual Meeting, Atlanta, 2018.
(Poster) Van Bruggen, S. and Unnikandam-Veettil, S., and Schneider, I., Tuning Gel Stiffness with Surface Chemistry to Study Cancer Cell Behavior. American Institute for Chemical Engineers Annual Fall Meeting, Minneapolis, 2017.
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(Poster) Schneider, I., Wang, J. and Nuhn, J., Contact Guidance in Breast Cancer Cells Depends on Substrate Flexibility and Correlates with Myosin Phosphorylation on Stress Fibers. American Society for Cell Biology Annual Meeting, San Francisco, 2016.
(Poster) Nuhn, J., Wang, J. and Schneider, I., Rotational Collagen Alignment Using Acupuncture Needles Reveals Diversity in Contact Guidance. Biomedical Engineering Society Annual Fall Meeting, Minneapolis, 2016.
(Poster) Wang, J., Boddupalli, A., Nuhn, J., Bratlie, K. and Schneider, I., Collagen Fibrils Attached to Flexible Substrates Reveal the Role of Mechanics on Contact Guidance. Biomedical Engineering Society Annual Fall Meeting, Minneapolis, 2016.
(Oral) Wang J and Schneider I, Uncovering Mechanisms That Result in Diverse Contact Guidance Behavior Amongst Cancer Cells. American Institute for Chemical Engineers Annual Fall Meeting, Salt Lake City, 2015.
(Poster) Wang J, Lara Rodriguez L, Petefish J, Hillier A and Schneider I, Uncovering Cell- type Specific Plasticity in Contact Guidance Efficiency Using Organized Collagen Substrates. Biomedical Engineering Society Annual Meeting, San Antonio, 2014.
(Poster) Wang J, Lara Rodriguez L, Petefish J, Hillier A and Schneider I, Plasticity in Contact Guidance Efficiency On Organized Collagen Substrates. Gordon Research Conference: Signal Transduction by Engineered Extracellular Matrices, Waltham, 2014.
(Poster) Haage A and Schneider I, Cellular and Contractility and ECM Stiffness Regulate Matrix Metalloproteinase Activity in Pancreatic Cancer Cells, American Society for Cell Biology Annual Meeting, New Orleans, 2013.
(Poster) Lara Rodriguez L, Willet S and Schneider I, Design and Fabrication of Engineered Platforms to Control Multiple-Cue Directional Migration, Biomedical Engineering Society Annual Meeting, Seattle, 2013.
(Poster) Hou Y, Lara Rodriguez L, Wang J and Schneider I, Collagen Attachment Controls Cell Clustering through Migration. Gordon Research Conference: Collagen: In the Context of Matrix, Cells and Regenerative Medicine, New London, 2013.
(Poster) Schneider I and Haage A, Cell Adhesion and Contractility Regulate Matrix Metalloproteinase Activity in Cancer Cells. International Conference on Biomolecular Engineering, Ft. Lauderdale, 2013.
(Poster) Zhang Y, Haage A, Cochrane A, Whitley E, Schneider I and Clapp A, Mixed- surface, Lipid-tethered Quantum Dots for Targeting Cells and Tissues. American Society for Cell Biology Annual Meeting, Denver, 2011.
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(Poster) Hou Y, Hedberg S and Schneider I, Adhesion and Protrusion Signatures Predict Cell-to-cell Variability in Response to EGF. American Society for Cell Biology Annual Meeting, Denver, 2011.
(Poster) Hou, Y., Hedberg, S. and Schneider, I., Adhesion and Protrusion Signatures Predict Cell-to-cell Variability in Response to EGF. American Society for Cell Biology Annual Meeting, Denver, 2011.
(Oral) Hou Y and Schneider I, Protrusion Dynamics and Focal Adhesion Maturation Drive Migration Variability under EGF Stimulation. American Institute for Chemical Engineers Annual Fall Meeting, Minneapolis, 2011.
(Poster) Romsey N and Schneider I, Micropatterned Substrates Mimic Contact Guidance Cues. American Institute for Chemical Engineers Annual Fall Meeting, Minneapolis, 2011.
(Poster) Hou Y and Schneider I, Protrusion and Focal Adhesion Maturation Drive Migration Variability under EGF Stimulation. Biomedical Engineering Society Annual Fall Meeting, Hartford, 2011.
(Poster) Schneider I, Hou Y, Romsey N and Harris G, Regulation of focal adhesion maturation and cell edge dynamics by epidermal growth factor. Biomedical Engineering Society Annual Fall Meeting, Austin, 2010.
(Poster) Schneider I and Hou Y, Timing and Spatial Control of Epidermal Growth-factor Mediated Focal Adhesion Maturation and Cell Edge Dynamics. Engineering Cell Biology III, Santa Cruz, 2009.
*(Poster) Schneider I, Kern C and Waterman C, EGF-induced Contraction Regulates Paxillin Phosphorylation to Temporally Separate Traction Generation from De-adhesion. Frontiers in Cell Migration: From Mechanism to Disease, Washington D.C., 2008.
*(Poster) Schneider I and Waterman C, Epidermal Growth Factor Stimulates Contractility and Focal Adhesion Maturation and Turnover. American Society for Cell Biology Annual Meeting, Washington D.C., 2007.
*(Poster) Schneider I and Waterman C, Characterization of Epidermal Growth Factor- stimulated Contractility and Adhesion Maturation and Turnover. Biomedical Engineering Society Annual Fall Meeting, Los Angeles, 2007.
*(Poster) Schneider I and Waterman-Storer C, Characterization of an Epidermal Growth Factor-stimulated Acute Lamella Retraction That Temporally Lags Lamellipodial Protrusion. American Society for Cell Biology, San Diego, 2006.
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*#(Poster) Schneider I, Parrish E and Haugh J, Quantitative Elucidation of a Unique Spatial Gradient Sensing Mechanism in Fibroblasts. American Society for Cell Biology, San Francisco, 2005.
*#(Poster) Schneider I and Haugh J, Platelet-derived Growth Factor-mediated Spatial Sensing in Fibroblasts is Governed by Three Regimes of Gradient Sensitivity. Gradient Sensing and Directed Cell Migration Gordon Research Conference I, Ventura, 2005.
*#(Poster) Schneider I, Parrish E and Haugh J, Phosphoinositide 3-kinase-dependent Migration of Fibroblasts Toward Platelet-derived Growth Factor (PDGF) is Governed by an Absolute Gradient Sensing Mechanism. American Society for Cell Biology, Washington D.C., 2004.
*#(Poster) Schneider I and Haugh J, Platelet-derived Growth Factor Receptor-mediated 3’ Phosphoinositide Lipid Dynamics in Living Fibroblasts. American Society for Cell Biology, San Francisco, 2003.
*#(Poster) Schneider I and Haugh J, Spatial Analysis of PDGF Receptor-mediated 3’ Phosphoinositide Lipid Dynamics in Living Fibroblasts. Biomedical Engineering Society Annual Fall Meeting, Nashville, 2003.
*#(Poster) Schneider I and Haugh J, Modeling PDGF Receptor-mediated 3’ PI Lipid Dynamics in Living Cells. Biophysical Society, San Antonio, 2003.
(Poster) Schneider I, Preston J, Rhamy J and Reilly P, High-performance Anion-exchange Chromatography of Sugar and Glycerol Phosphates on Quaternary Ammonium Resins, Biochemical Engineering Symposium, Norman, 1999.
B. Patents, Disclosures, and Technology Transfer
n/a
C. Funded Grants and Contracts
Schneider I and Bartlett M Topographical Control of Local Stiffness to Direct Cancer Cell Migration College of Engineering, Iowa State University 8/15/17-1/31/18 $20,302 (~$14,000) PI
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Ge X (University of California Riverside), Blaha G (UCR), Schneider I and Walker A (UCR) Structure-based Design of Camel-like Human Selective mAbs against MMPs in Disease National Institute of General Medical Sciences, National Institutes of Health 6/1/2016-5/31/2017 $1,500,000 (~$57,279) Co-Investigator (subaward)
Que L , Jiles D, Hadimani R and Schneider I On-chip studies of neuron cells under magnetic field stimulation National Science Foundation, ECCS, CCSS 06/01/2016-05/30/2019 $363,333 (~$14,415) Co-PI
Schneider I and Que L Drop Forming Devices for Generating Tumor-mimicking Drug Screening Platforms Engineering Research Institute, ISU 5/25/15-11/25/15 $11,500 ($11,500) Co-PI
Schneider I Probing Contact Guidance on Exquisitely Tunable ECM Surfaces National Cancer Institute, National Institutes of Health 4/1/14-3/31/16 $137,896 ($137,896) Sole PI
Schneider I Engineering Complex Environments for Probing Mechanisms of Cell Migration Roy J. Carver Charitable Trust 11/1/11-10/31/14 $308,200 ($308,200) Sole PI
Schneider I Bioengineering Tutorial on Technologies for Understanding Multi-cue Integration during Cell Migration Office of the Executive Vice President and Provost, Iowa State University 7/1/11-6/30/12 $4000 ($4000) Sole PI
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D. Pending Grants and Contracts
Lamm M and Schneider I REU Site: Biological Materials and Processes (BioMaP) National Science Foundation, EEC, EWD 5/1/19-4/30/22 $354,792 ($4,500) Co-PI
III. TEACHING AND STUDENT MENTORING
A. Instruction for ISU
Term (most Course Course Title Credits Lab Number of TA/graders recent first) number students Fall 2018 ChE 357 Transport Phenomena II 3 No 49 1/1 Fall 2018 BBMB 303x General Biochemistry 3 No 79 1/0 (~10% effort) Spring 2018 ChE 356 Transport Phenomena I 3 No 54 1/1 Spring 2018 ChE 406/506 Environmental 3 No 29 0/1 Chemodynamics Fall 2017 Che 698 Chemical Engineering 1 No 23 0/0 Teaching Practicum (~50% effort) Fall 2017 BBMB 303x General Biochemistry 3 No 71 1/0 (~10% effort) Spring 2017 ChE 406/506 Environmental 3 No 29 0/1 Chemodynamics Spring 2017 ChE 356 Transport Phenomena I 3 No 53 1/1 Fall 2016 ChE 357 Transport Phenomena II 3 No 82 1/2 Fall 2016 Che 698 Chemical Engineering 1 No 15 0/0 Teaching Practicum (~50% effort) Fall 2016 BBMB 301 Survey of Biochemistry 3 No 135 1/0 (~10% effort) Spring 2016 ChE 356 Transport Phenomena I 3 No 50 1/1 Spring 2016 ChE 695K Biomaterials and Tissue 3 No 9 0/0 Engineering (15% effort) Spring 2016 ChE 406/506 Environmental 3 No 32 0/1 Chemodynamics (70% effort) Fall 2015 ChE 356 Transport Phenomena I 3 No 60 0/1 Spring 2015 ChE 356 Transport Phenomena I 3 No 71 1/1 Fall 2014 ChE 356 Transport Phenomena I 3 No 72 0/1 Spring 2014 ChE 601 Seminar R No 50 1/1
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Spring 2014 ChE 356 Transport Phenomena I 3 No 68 0/1 Fall 2013 ChE 601 Seminar R No 50 1/1 Fall 2013 ChE 356 Transport Phenomena I 3 No 61 0/1 Spring 2013 ChE 356 Transport Phenomena I 3 No 43 0/1 Fall 2012 BMS 575 Cell Biology (15% effort) 3 No 4 0/0 Fall 2012 ChE 210 Material and Energy 3 No 51 0/1 Balances Spring 2012 ChE 415/515 Biochemical Engineering 3 No 35 0/1 Fall 2011 BMS 575 Cell Biology (15% effort) 3 No 9 0/0 Fall 2011 ChE 440/540 Biomedical Applications 3 No 24 0/0 of Chemical Engineering Fall 2010 BMS 575 Cell Biology (15% effort) 3 No 4 0/0 Fall 2010 ChE 104 Chemical Engineering R No 59 0/0 Learning Community (50% effort) Fall 2010 ChE 440/540 Biomedical Applications 3 No 34 0/0 of Chemical Engineering Spring 2010 ChE 356 Transport Phenomena I 3 No 37 1/1 Fall 2009 ChE 210 Material and Energy 3 No 44 0/1 Balances Spring 2009 ChE 356 Transport Phenomena I 3 No 33 0/1
B. Curricular Development Activity for ISU
BBMB 301 and 303x, Survey of Biochemistry (General Biochemistry), 2016-18, with four other instructors we added 5 weeks of chemical engineering case studies to BBMB 301 and changed the course to BBMB 303x. In addition, I coordinated the assessment and class management during the course ChE 440/540, Biomedical Application of Chemical Engineering, 2010-11, developed material covering systems biology, data-driven modeling, cell biomechanics, cancer therapeutics and diagnostics, bioethics and FDA approval process for devices. ChE 415/515, Biochemical Engineering, 2012, developed co-culture lab based on kombucha fermentation Che 357, Transport Phenonena II, 2016, developed final project and incorporated a pre- test deployed in blackboard to assess the student’s performance in prerequisites ChE 356, Transport Phenomena I, 2009, 2015-2017, developed unique final projects and incorporated a pre-test deployed in blackboard to assess the student’s performance in prerequisites ChE 210, Material and Energy Balances, 2009, developed final project
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C. Supervision of Students as Major Professor
1. Shalini Unnikandam-Veettil, PhD ChE, November 2016-present, work in progress – degree expected May 2021. 2. Jacob Nuhn, PhD ChE, November 2013-August 2018, The Role of Contact Guidance on Cancer Metastasis, now at KBI Biopharma. 3. Juan Wang, PhD ChE, November 2012-December 2017, Probing Breast Cancer Cell Contact Guidance in Organized Collagen Environments, Post-doc at the University of Washington. 4. Laura Lara-Rodriguez, PhD ChE, January 2011-October 2014, Design and Fabrication of Engineered Platforms to Control Multiple Cue Directed Cell Migration, now at 3M. 5. Amanda Haage, PhD MCDB, February 2011- August 2014, Microenvironment Regulation of Matrix Metalloproteinase Activity in Pancreatic Cancer Cells, Post- doc at the University of British Columbia. 6. Yue Hou, PhD ChE, November 2008-August 2013, Orchestrating Cancer Cell Migration: Quantitative Analysis of Protrusion, Adhesion and Contraction Dynamics Regulated by Epidermal Growth Factor and Collagen, now at Dana-Farber Cancer Institute.
D. Service on Graduate Student Committees
Sadaf Charkhabi, in progress, PhD, Chemical and Biological Engineering Joseph Boldrey, in progress, PhD, Electrical Engineering, committee member Lumen Liu in progress, PhD, Chemical Engineering, committee member Xiaojing Zhong, in progress, PhD, Electrical Engineering, committee member Ramesh Koirala, in progress, PhD, Physics, committee member Ben Schlichtmann, in progress, PhD, Chemical Engineering, committee member Yanhua Huang, in progress, PhD, Material Science and Engineering, committee member Zhuqing Li, in progress, PhD, Material Science and Engineering, committee member Pallavi Sinha Roy, in progress, PhD, Molecular Cellular and Developmental Biology, committee member Zahra Davoudi, in progress, PhD, Chemical Engineering, committee member Joseph Banovetz, in progress, PhD, Chemistry, committee member Emmanuel Nsamba, in progress, PhD, Genetics, committee member Sujata Senapati, PhD, in progress, PhD, Chemical Engineering, committee member Sean Kelly, in progress, PhD, Chemical Engineering, committee member Adam Mullis, in progress, PhD, Chemical Engineering, committee member Melanie Torrie, in progress, PhD, Genetics, committee member Subin Mao, 2019, MS, Electrical Engineering, committee member Russell Mahmood, 2019, PhD, Chemical Engineering, committee member Zhiqi Yao, 2018, PhD, Chemical Engineering, committee member Srikanth Nayak, 2018, PhD, Chemical Engineering, committee member Xiangchen Che, 2018, PhD, Electrical Engineering, committee member
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Anuraag Boddupalli, 2018, PhD, Chemical Engineering, committee member Shenmin Gong, 2018, MS, Electrical Engineering, committee member Laura Schultz, 2018, PhD, Genetics, committee member Yong Mei, 2017, PhD, Chemical Engineering, committee member Lida Zhu, 2017, PhD, Materials Science and Engineering, committee member Hannah Bygd, 2016, PhD, Materials Science and Engineering, committee member Yingfei Chen, 2015, PhD, Chemical Engineering, committee member Jonathan Goodman, 2015, PhD, Chemical Engineering, committee member Yuan He, 2015, PhD, Electrical Engineering, committee member Joe Petefish, 2014, PhD, Chemical Engineering, committee member Shannon Haughney, 2014, PhD, Chemical Engineering, committee member Julia Vela, 2014, PhD, Chemical Engineering, committee member Dana Akilbekova, 2014, PhD, Materials Science and Engineering, committee member Alyssa Brown, 2014, MS, Materials Science and Engineering, committee member Dandong Wang, 2014, MS, Materials Science and Engineering, committee member Feng Jia, 2013, PhD, Chemical Engineering, committee member Gwen Truong, 2013, PhD, Chemical Engineering, committee member Kathleen Ross, 2013, PhD, Chemical Engineering, committee member Wei-Hsun Yeh, 2013, PhD, Chemical Engineering, committee member Ji Won Ha, 2013, PhD, Chemistry, committee member Latrisha Petersen, 2011, PhD, Chemical Engineering, committee member Carlos Ariza, 2009, PhD, Chemical Engineering, committee member
E. Supervision of Post-Doctoral Students and Professional Staff
Yanjie Zhang, 2011-2012, Quantum Dot Matrix Metalloproteinase Sensors, now at Global Foundries
F. Supervision of Independent Study and Undergraduate Research
Christian Gaulker, 2019, Assessing Alginate Gels for Controllign Durotaxis using 3D Printed Topographies Matthew Anders, 2019, Assessing Alginate Gels for Controllign Durotaxis using 3D Printed Topographies Alexander Kom, 2019, Assessing Alginate Gels for Controllign Durotaxis using 3D Printed Topographies Brandon Song, 2018, Effects of Hyaluronan on Cell Migration Mohamed Shogar, 2018, Effects of Hyaluronan on Cell Migration Jaclyn Simons, 2018, Leveraging Topography to Control Cell Migration through Durotactic Gradients Remi Smith, 2018-present, Measuring Matrix Metalloproteinase Activity in 3D Brianna White, 2018, Leveraging Topography to Control Cell Migration through Durotactic Gradients Marissa Gustafason, 2018, Assessing 3D Printed Topographies for Controlling Durotaxis
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Christopher Gelina, 2018, Assessing 3D Printed Topographies for Controlling Durotaxis Joseph Koelbl, 2015-2018, Role of Mechanical Properties in Controlling Contact Guidance John Geerdes, 2015-2016, Alginate Gels for Tumor Microenvironment Mimics Anai Perez, Summer 2016, Myosin and Paxillin Regulation during Stiffness Sensing in 3D Collagen Gels Shawn Van Bruggen, 2015-2018, Assessing Durotaxis in Pancreatic Cancer Cells Forrest Cauley, Summer 2015, Quantifying Chemotaxis Ryan McSweeney, Summer 2015, Quantifying Contact Guidance Kofi Oduro-Nsenkyire, 2015-2017, Collagen-Alginate Interpenetrating Networks Jacob Harry, Spring 2015, Propellant Delivery System for Rocket. Zhou Jiang, 2014-2015, Adhesion and Migration of Cancer Cells on Epitaxially Growth Collagen Matrices Alicia Schnoebelen, Fall 2014, Design of a Microscope to be Placed within a Conventional Incubator. David Erickson, Fall 2014, Design of a Microscope to be Placed within a Conventional Incubator. Cole Daly, Fall 2014, Design of a Microscope to be Placed within a Conventional Incubator. Nicholas Seymour, Spring 2014, Characterization of Collagen Gelation and Cell Migration in Hanging Drop Assays Alicia Kramer, Fall 2013, Effects of Matrix Stiffness on Proteinase Activity Christian Pinnell, Spring 2013, The Development of Aligned Collagen Matrices Using Ferromagnetic Beads Stacy Willet, Summer 2013, Multiple Cue Migration Response of MDA-MB231 Human Breast Cancer Cells Nick Romsey, 2009-2012, Cell Migration on Microcontacted Printed Collagen Ngoc Phan, 2012, The Effect of Collagen Density on Cell Migration Andrew Ford, 2011-2012, Photocontrolled Cell Adhesion on a Surface Functionalized With a Caged RGD Peptide Carin Lightner, 2011-2012, The Formation of Aligned Collagen Fibers on Muscovite Mica Tim Ouverson, 2011-2012, Orthogonal Line Multiprotein Stamping and Cell Spreading in Competing ECM Kelsey Schieltz, Spring 2012, Plectin-1 Targeted Quantum Dots Michael Zimmerman, Spring 2012, Measuring Cell Migration using a High Throughput Flow Cytometry Method Aaron Wood, Summer 2012, Mechanism of Photoannealing of Quantum Dots Augustine Villa, Summer 2012, Variation of Cell Migration Speed with Changing Collagen Density and Substrate Conditions Kianna Elahi, 2011, Control of Thick 3D Collagen Extracellular Matrices Vania Romay, Spring 2011, A Proposal for Aligning 3D Collagen Matrices using a Strong Magnetic Field Nic Wetzel, Spring 2011, The Aggregation of Quantum Dots in Different Mediums
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Sara Hedberg, 2010-2011, Cell Migration Behavior in the Presence of Uniform Doses and Gradients of EGF Abdulrahman Ahmadi, 2010-2011, Cell Migration within PDMS Microfluidic Devices Alex Cochrane, Summer 2011, Targeting and Trafficking of Quantum Dots Zach Benedict, Summer 2011, Procedure for Creating Aligned Collagen Matrices Using Non-Electrical Methods for Use in 3D Cell Migration Research Samantha Chalfant, Spring 2010, Regulating Cell Adhesion to RGD Using Photochemistry Amanda Machacek, 2009-2010, The Effect of Collagen on Migrating MTLn3 Cells Daniel Flores, Summer 2010, Secretion of M-CSF during paracrine loop signaling is optimal at intermediate stimulation conditions Dorothea Craigen, Summer 2010, The Effects of Paxillin Tyrosine Phosphorylation and Actin Dynamics on Cell Migration Carolyn Zahler, Summer 2009, One-dimensional Control of Cell Migration Through the Use of Microcontact Printing Cristen Hays, 2007-2008, Phosphorylation of Focal Adhesion Proteins in Epithelial Cells Elizabeth Parrish, 2003-2005, Computational Analysis of PI-3 Kinase-induced Signaling Hot Spots
G. Non-ISU Instruction (e.g. Short Courses, Workshops, Training)
n/a
H. Other Teaching and Student Mentoring Contributions
Preparing Future Faculty Mentor for Anuraag Boddupalli (2017-2018) One day workshop on teaching engineering, (July 2017, 2016 and 2018) InTrans, gave a presentation on the engineering process and concepts and led a discussion on how to incorporate them into elementary education. One day workshop on biorenewables, July 2015, Coover Hall, gave a presentation on the engineering process and concepts and led a discussion on how to incorporate them into elementary education. Elementary school teacher in-service retreat, July 2015, Parkview Middle School, gave a presentation on the engineering process and concepts and led a discussion on how to incorporate them into elementary education. Academic Program for EXcellence (APEX) tutorial: Engineering Environments for Cells, (June 2013, 2014, 2015, 2016, 2017 and 2018), Sweeney Hall. Summer Program for Enhancing Engineering Development (SPEED) tutorial: Engineering Environments for Cells, June 18, 2012, Sweeney Hall, developed soft biomaterials demonstrations. Hosted Matthew Constant, a senior at Ames High School, Fall 2012. Hosted Victor Wang, a senior at Ames High School, Summer 2011. Hosted Tanea Hibler from the Academies Creating Teacher Scientists teacher and Research Experience for Teachers, Summer 2010 and Summer 2011.
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Presented lectures in Advanced General Chemistry, Chem 201 (Fall 2013, 2014, 2015 and 2016), Introduction to Biomedical Engineering, BioE 220 (Spring 2014) and Biomedical Applications of Biomedical Engineering, ChE 440/540 (Fall 2017 and 2018)
IV. INSTITUTIONAL SERVICE
A. University-Level Service
Member, Faculty Senate (2017-present) Member, Faculty Senate Governance Council (2017-present) Member, Genetics Development and Cell Biology Search Committee (2016-2017) Member, Engineering Faculty Senate Caucus (2017-present) Triangle Fraternity advisor (2009-2011 and 2014-present) Reviewer for internal grant competitions (2014 and 2015) Member, Tuition, Course and Lab Fee Budget Taskforce (2010) Member, GDCB Search Committee (2017)
B. College-Level Service
Director, Biomedical Engineering Minor (2018-present) Member, Biomedical Engineering Minor Steering Committee (2012-present) Engineering Leaders of Tomorrow conference committee adviser (2017-present) Biomedical Engineering Society advisor (2018-present) Member, Engineering College Curriculum Committee (2011-2017) Scholar’s day presenter for the Biomedical Engineering Minor Program (2014, 2015 and 2017) Member, Translational Health Search Committee Member (2013-2014) Member, Committee to reorganize the Bioengineering Minor (2012)
C. Department-Level Service
Assistant Professor Mentor (2017-present) Member, CBE Curriculum Committee (2009-present) Member, CBE-BBMB Biochemistry Curriculum Development Committee (2016-present) Member, MCDB Curriculum Committee (2011-2016) Member, Chemical Engineering Chair Search Committee (2012-2013) Member, Faculty Handbook Taskforce (2011) Member, Biomaterials Faculty Search Committee (2010-2011) Member, CBE Open Faculty Search Committee (2015-present)
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V. PROFESSIONAL SERVICE
A. Editorial and Review Service for Manuscripts
ACS Biomaterials Science and Engineering, reviewer (1), 2016 ACS Interfaces, reviewer (1), 2015 Acta Biomaterialia, reviewer (3), 2013-present AIChE Journal, reviewer (1), 2015 Annals of Biomedical Engineering, reviewer (1), 2017 BBA-Molecular Cell Research, reviewer, reviewer (1), 2014 Biomaterials, reviewer (2), 2016 Biomedicines, reviewer (1), 2014 Biotechnology and Bioengineering, reviewer (2), 2010-2013 Biophysical Journal, reviewer (11), 2009-2016, 2018 Biosensors, reviewer (1), 2017 Cellular and Molecular Bioengineering, reviewer (2), 2011-2015 Experimental Cell Research, reviewer (2), 2015-2016 Integrative Biology, reviewer (3), 2014-2016 Journal of Biomedical Materials Research Part A, reviewer (1), 2016-present Molecular Biology of the Cell, reviewer (4), 2016-present Nature Communications, reviewer (1), 2016 Physical Biology, reviewer (2), 2010-2012 PLOS ONE, reviewer (2), 2015 PLOS Computational Biology, reviewer (1), 2015 RSC Advances, reviewer (1), 2016 RSC Interfaces, reviewer (1), 2018 Scientific Reports, reviewer (5), 2014-present Science Advances, reviewer (1), 2018-present Soft Matter, reviewer (1), 2017-present Tissue Engineering, reviewer (2), 2011-2013
B. Service to Professional Societies
Biomedical Engineering Society, Student Affairs Subcommittee, 2018-2022 Sigma Xi, nominating committee member for local chapter, 2014 and 2017
C. Grant Review Activities
NIH, ad hoc Reviewer for NIH Special Emphasis Panel and stage 1 Reviewer for NIH Special Emphasis Panel Wellcome Trust, mail Reviewer NSF, panelist for ENG directorate
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D. Government, Educational, or Corporate Advisory Committees
n/a
E. Other Professional Service
Molecular and Cellular Engineering Track, 2010, 2017-2018, Biomedical Engineering Society annual meeting abstract reviewer Engineering Cells and Microenvironments for Tissues, 2015, American Institute of Chemical Engineers annual meeting, session chair Cell Migration and Adhesion, 2014, American Institute of Chemical Engineers annual meeting session chair, session chair Biophysical and Microscale Analyses of Molecular and Cellular Function, 2013, 4th International Conference on Biomolecular Engineering, session chair Receptor Mediated Processes, 2013, American Institute of Chemical Engineers annual meeting, session chair Cell Adhesion and Migration, 2012, American Institute of Chemical Engineers annual meeting, session chair Intracellular Processes, 2011, American Institute of Chemical Engineers annual meeting, session chair
VI. OUTREACH, COMMUNITY ENGAGEMENT AND OTHER ACTIVITIES
A. Outreach Activities
Developed cell migration and biomaterials modules for a middle school-aged NanoCamp participants at the Science Center of Iowa, August 2014 Participated in NanoDays by developing demonstrations on epitaxial growth of collagen fibrils and cell migration at the Science Center of Iowa, April 2014 Graduated from Portal to the Public, a program to teach scientists and engineers how to translate knowledge to a lay audience, 2013 Conducted demonstrations on cell migration at the Science Center of Iowa, November 2013 Participated in NanoDays by developing demonstrations on epitaxial growth of collagen fibrils and magnetic bead alignment at the Science Center of Iowa, April 2013
B. Community Engagement Activities
n/a
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