.the

U. 5. DEPARTMENT OF June 29, 1976 N"'TION"'I. INSTITUTES OF HEAi.TH HEALTH. EDUCATION. AND WELFARE Vol. XXVJII, No. 13 Dr. Ruth Hegyeli Named Recombinant DNA To New Post in NHLI For lnternat'I Programs Guidelines Issued; Dr. Ruth Johnsson llegyeli has Effective June 23 been appointed assistant to the Di­ rector, Nat.iom1l Heart and Lung Guidelines for the conduct of Institute, for lnternational Pro­ experiments involving recombinant grams--a new posi lion created by DNA molecules were released on the growth and success of such June 23 by NIH Director Dr. Don­ activities. ald S. Fredrickson, as well as a Formal Plo"s l"itiotod document describing the factors he After many years o-r interna­ took into account in reaching his tional scientific collaboration in the decision to issue the Guidelines. Institute's program areas, mainly by tho informal exchange of in­ Widespread Adoption Expected formation, more formal arrange­ E ffective June 23, the NIH Guide­ ments were initiated in the early lines will govern research at NIH One of 50 prominc"t Americo"s who will discuss aspects of the Nation's laboratories and those of its gran­ 1970's under the auspices of future over NBC radio duri"g the July 4th weekend, NIH Director Or. Donald NHLI's Office of Program Plan­ tees and contractors. They are S. Fredrickson is i"tcrviewed i" his office by re porte r Be" Locy (c) ond e"• also expected to be adopted by ning and Evaluation. gi"eer Charles Hall (I). The 5-minute segment focuses on America" medici"e Scic"tists Collaborate other laboratories throughout the i" the year 2076. A"othcr segmcmt features Or. Robert H. Butler, Director U.S. and foreign countries. For example, the US-USSR of the National J"stitute on Aging. At press time, exoct schedules far oiring Health Exchange Program, for had nat been set. NIH has also undertaken an en­ which Dr. Hegyeli has had respon­ vironmental impact assessment of sibility since 1972, is part of a these Guidelines for recombinant Government a~reement providing Swine Flu Vaccine Trial Data Discussed: DNA research in accordance with for direet collaboration between the National Environmental Policy scientists in planning and execut­ Few Reactions; Age Differences Observed Act of 1969 (NEPA). The assess­ ing research in five cardiovascular Studies involving more thnn 5,000 volunteers reveal that immunization ment will review tho environmen­ problem areas, blood transfusion, of adults against swine-like flu can be accomplished without difficulty, tal effects, if any, of research thnt and development of an artificial according to Dr. David Sencer, Director of the Center for Disease may be conducted under the Guide­ heart. Control, Atlanta. Dr. Sencer made lines. Born and raised in Sweden, D r. this announcement at a press con­ Freedom of Information Recombinant DNA molecules re­ Ilegyeli received her B.A. in 1958 ference held in Bethesda June 22 sult from recombination in the test and he-r l\I.D. in 1962 from the Procedures for Grantees when committees advisory to the tube of segment., of deoxyribonu­ University of Toronto, Canada. FDA's Bureau of Biologics and to Outlined by Dr. Cooper cleic acid, the material which de­ Before joining the NHLI Arti­ PBS reviewed data from vaccine Dr. Theodore Cooper, HEW As­ termines the hereditary character­ (See DR. l-/EGYELI, Page 4) trial_s, coordinated by the '.:\Tati~nal sistant Secretary for H ealth, has istics of all Jiving cells. notified PHS grantees o! a new Institute of Allergy and Infectious These techniques have a -remark­ procedure when requestors ask for Diseases. able potential for furthering the grant files under the Freedom 01' At the same time, Dr. Sencer understanding of fundamental bio­ Information Act. pointed out thnt none of the vac­ chemical processes in cells of lower When a request is received, an cines prepared by four different and higher organisms, and promise FOI contact----Officially designated drug companies were pre~ently to revolutionize molecular biology. suit.able for use in normal children in each B /1/D-wi.U telephone the grantee. The latter will indicate Pote"tial HoEords Involved and young adults. within 3 days whether informa­ But the technology, which per­ Cooper to Decide tion in the file concerns a potential mits genetic information from very On the basis of this informa­ patent or whether the information different organisms to be combined, tion, along with other pertinent is copyrightable. also involves potential hazards data, HEW Assistant Secretary If a potential patent is involved, which 1.\1'8 difficult to evaluate. for Health Dr. Theodore Cooper the HEW patent coun~el will make Therefore, the research must pro­ will make decisions on plans a final determination. Information ceed with considerable caution. for mass immunization this fall that could lead to a patent will not Medical advances to be expected against the new swine-like virus be relea8ed. through the use of this technology firtit isolated last February in New If the grantee intends to copy­ include the opportunity to explore Jersey. right part of his grant application the functioning of cells in compli­ Dr. Sencer indicated that be felt or other material, an NIU contact cated diseases. Understanding of Dr. Hegyeli is o Fellow of the Acad­ it would be possible to begin offer­ will mark it with a notice to pro­ a variety of hereditary defects may emy of Medicine, Toro"to, o"d re­ ing vaccine to all adults-two­ tect it. be significantly enhanced, and some ceived the DHEW Certificate for Su­ thirds of the u.S. population-in Dr. Coopei-'s letter was made perior Service i" 1975. (See FLU VACCINE, Page 8) (See FREEDO,ll, Page 6) (See GUIDELINES, Page 5) Page 2 June 29, 1976 THE NIH RECORD Record Published biweekly at Bethesda, Md., by the Editorial Operations Branch, Division of Public Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­ gators in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on request. The NIH Record reserves the right to make corrections, changes, or dele­ tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare.

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Editor ...... Fronces W. Dovis Associate Editor ...... Foy Levicro Associate Editor ...... Heather Banks

Stoff Correspondents ADA, Judy Fouche; CC, Susan Gerhold; DCRT, Frances Sarles; DRG, Sue Meadows; DRR, Jerry Gordon; DRS, Arthur F. Moore; FIC, George Presson; NCI, Dr. Robert M. Hadsell; NEI, Inez E. Connor; NHL!, Bill Sanders; NIAID, Margaret McElwain; NI.AMDD, Pat Gorman; NlCHD, Doreen Mead; NIDR, Sue Hannon; NIEHS, Elizabeth Y. James; Michael Sposito of Curwensville, Pa., enjoyed o special tour of NIH on June NIGMS, Wanda Warddcll; NIMH, Betty Zubovic; NINCDS, Carolyn 14--thc result of o letter written by his teacher, Michael Keely, to President Holstein; NLM, Fraun Patrick. Ford. A keen science student, 14-year-ald Mike is a muscular dystrophy patient facing major surgery this summer. He and his parents talked with 3 Units Exceed U.S. Savings Bond Campaign Goal the NIH Director and visited exhibits and the Clinical Center, where Dr. Michael Vermess (r) explained the EMI scanner, and scientists discussed re­ The final report for the 1976 the th1·ee top components: Aud1·ey search in nuclear medicine, echacardiagraphy and pulmanory bioche mistry. NIH U.S. Savings Bond Campaign Levy, DRR; Errett Straley, Jr., shows that nearly 500 employees DRG, and Betty McDonald, NLM Bicentennial Report Joggers Celebrate July 2 signed up Ior bonds fo1· the first NINCDS. He also commended the time or increased their current outstanding campaign canvassers. Chronicles Historic Role With Bicentennial Runs- payroll allotments. Dr. Bowery reminded employees A special edition annual report, 1-Mile, to White House At the assembly for bond buyers that the fact that the Campaign is entitled Communication in the To encourage physical fitness, on June 25 in the Masur Audito1·­ over doesn't preclude them from Service of Amer·ican Health ... A the NIH Jogging Club, Health's ium, Dr. Thomas G. Bowery, DRR increasing their Savings Bond al­ Bicentennial Report from the Na­ Angels, is sponsoring a Bicenten­ Director and Vice Chairman of lotment at any time. tional Library of Medicine, includes nial Classic July 2, beginning at this year's Campaign, reported New bond buyers and those who extensive descriptions of the role noon in front of Bldg. 1. that there were 331 new bond buy­ had increased their allotments NLM has played in American med­ Dr. Thomas E. Malone, Nill As­ ers, and 156 employees increased were eligible for the prize drawing. icine since 1836, in addition to cov­ sociate Director for Extramural their allotments. Ed Condon, president of the R&W ering the activities of fiscal year Research and Training, will be the which contributed the three prizes, 1975. starter for both planed events-a Three B/1/D's exceeded their conducted the drawing. assigned goals. The Division of An introductory chapter by NLM 1-mile walk, jog, or run on the Research Resources was the high­ Socia I Security Protection Director Dr. Martin M. Cummings NIH campus, and a 10-mile run to est, with 191% of its goal.~-~ Explained to Young Families chronicles the develo1>ment of the White House, where Dr. Ash American medical literature from E. Hayes of the President's Coun­ ..., T~Divi-iio;(of R;;earch Grants Young workers with dependents was second with 106% of its goal, its inception with a pamphlet on cil on Physical Fitness and Sports should find out what would happen will meet the runne1·s. and the National Institute of Neu­ smallpox ( 1678). if they become disabled or die. To Commemorative certificates and rological and Communicative Dis­ A second chapter by Scott learn about protection for the ribbons will be awarded to all per­ orders and Stroke was thil'd high­ Adams, NLM deputy director from worker and his family, contact sons completing either event. Those est with 104%. any Social Security office and ask 1960 to 1970, describes the evolu­ tion of indexing and index publica­ planning to participate in the 10- Dr. Bowery presented award for a free booklet, Social Securit11 mile run should pi-e-registcr with tions at the Library between 1876 certificates to the coordinators for lnfonnation for Young Fam,il-ies. Jogging Club co-presidents Dr. and 1960. David Young, Ext. 65433, or Jay Other chapters cover toxicologi­ Miller, Ext. 66941. cal information, library operations, Declare financial independence. history of medicine collections, ex­ EHS Changes Its Name to tramural programs, inte1·national Occupational Med. Service activities, the National Medical The name of the Employee Audiovisual Center, the Lister Hill Health Service has been National Cente1· for Biomedical changed to the Occupational "' Communications, and NLM admin­ Medical Service. istration. The change was made to re­ Copies of the report have been flect more accurately this Clin­ sent to institutional members of ical Center program's func­ the Medical Library Association. tion to provide occupationally­ Single copies may be requested by related medical services-both sending a self-addressed mailing therapeutic and preventive. label to: Office of Inquiries, There will be no change in ATTN: Report, NLM, 8600 Rock­ services provided to employees. ville Pike, Bethesda, Md. 20014. THE NIB RECORD .Tune 29, 1976 P age 3 Andrew F. Perry Retires; llfrhrral (!littil &.eruauta Brrr wlrerr! Commuters, Computer I' Filled Variety of Roles Create Car Pools; While Working Here ijrlprh tn Cttrratt @ur Natinu\1 iijrritagr "It's been a Jong time coming, When this Nation was founded some 200 years ago, Federal civil Spaces Given Numbers but it finally came.'' servants were thet·e, helping to build the foundation. Andrew F. Perry of the National The first civil servant, Charles Thomson, was secretary of the First Institute of Arthritis, Metabolism, ConlinenLal Congress. Ile even and Digestive Diseases retired served as president of the Congi-ess cracy, were actually self-sacrificing June 1 after 28 years of Govern­ for a time. novices lacking even the benefit of ment service. He also kept The Congressional precedent." Mr. Perry began his Federal ca­ Journal, managed printing, worked Then as the country became or­ reer at Waltel· Reed Hospital in on treaties, and signed press re­ ganized under its new constitution, 1941, and joined NJAMDD in 1951. leases. of course, its staff of civil servants A three-letter-man from Arm­ At its peak bis office had two grew accordingly, with U.S. Mar­ strong High School in Washington, shals playing an hislorically well­ D.C., his skills as an outstanding clerks, a deputy secretary, and a messenger-"all ovenvorked." known role. baseball player helped NIH to win Mr. Thomson continued as a civil President Thomas Jefferson even several championships. servant until 1789, and carried the delegated census taking to them, a When he first came to NIH, Mr. task they performed until 1880. Perry participated in research first official notification of Wash­ ington's election to the Presidency That year is also a significant dealing with the growth and care one for civil servants because it of ge1·mfree animals. to Mt. Vernon. The earliest woman Federal em­ marks the lowest point of the spoils Later he proved his versatility system with the assassination of in fulfilling a va1·iety of roles, in­ ployee appears to be Mary K. God­ da1·d, who first became postmaster President James A. Garfield by a POOL IT cluding staffing exhibits for the disappointed job seeker, an act NIAMDD Office of Scientific and for BalUmore in 1773 under the that aroused public sentiment for Technical Reports at scientific and colonial government of Maryland, The 2,646 Commuter Club Ques­ civil service reform and led to medical meetings across the coun­ then continued in that post under tionnaiTes that so far have been the Revolutionary government. passllge of the Civil Service Act returned to the Parking and Traf­ tTy. of 1883. In addition to his administrative By 1784, however, the central fic Control Office have been pro­ The concept of a civil service duties, Mr. Perry has supervised government had grown further. cessed by the Washington Area many summer employees. He has John Jay, Secretary of Foreign based on merit continued to ex­ Council of Govern­ received numerous commendations Affairs, had a staff consisting of pand as civil servan!ts demon­ ments. from the Institute's executive and an under secreta1·y, doorkeeper, strated their capabilities in World Each employee administrative officers. messenger, clerks, and three in­ Wars I and II. who submitted a After his retirement Mr. Perry terpreters. During World War II, the civil­ - questionnaire will expects to travel extensively ·with As one writer commented on the ian workforce increased to its soon receive an in­ his wife, Etoile, supervisor-director Revolutionary Pe1·iod, "working record level of 4 million. Two sub­ dividualized print­ for a government that was still in sequent wars brought somewhat out showing the the formative stage, the civil ser­ smaller peaks. name and work ants of this period, far :from con­ Federal employees have figured telephone number stituting an entrenched bureau- prominently in many national en­ of other employees deavors. who live nearby. In World War II, Govet·nment Additional information and de­ FAES Social, Academic scientists made crucial contribu­ tailed instructions on car pool re­ • ,I Center Plans to Start tions including the development of quirements will be included along Regular Schedule by Fall radar. More 1·ecently the space with tho printout. The Foundation for Advanced 1·ace put the first man on the moon Numbers are presently being Education in the Sciences recently - Neil Armstrong, a civil servant. painted in selected parking Jot purchased the Public Health Serv­ areas to designate car pool spaces, ice Officers' Club at Old George­ 'Research Advances 1975' the number reserved to be determ­ town Road and Cedar Lane, Be­ ined according to the demand. Wins Another Award Spaces which are not assigned to thesda, to serve as an academic and NIH's Research Advances 1975 social center. car pools will be used for general won a second place Blue Pencil parking. The new center, inti·oduced to the Award in the Annual Reports Cat­ A car pool parking manual is­ membership at a yard party on egory at the National Association Mr. Perry {I) accepts good wishes of June 17, will be in full use with suance and schedule of car pool of Government Communicators' registration dates will soon be dis­ NIAMDD Director Dr. G. Donald regularly scheduled social hours 13th annual banquet on June 16. Whedon for a joyous retirement. and seminars by fall. tributed desk to desk. The award was presented to Questionnaires may still be ob­ of preschools in the District of Co­ lt has been redecorated and air­ Harold F. Osborne, who edited the tained from or returned to the lumbia, and his son, Keith, and conditioned and may now be rented report when he was director of the Parking Office, Bldg. 31, Room plans to revisit those cities whete for meetings or other functions. Division of Scientific Repo1-ts, Of­ Bl-Cll. For further information, he manned NIAMDD's exhibit The FAES sponsors the Gradu­ fice o-f Communications, OD. Mt·. call Ext. 66851. booths, including San Francisco ate Program at NIH, the Book­ Osborne is now with the Veterans and New Orleans. store, and the NIH Concert Series. Administration. Tutors in Special Subjects Officers elected for the coming Charles Gailis, in the Division of Needed for Summer Employees NLM Posts New Hours year a1·e: president, Dr. Robert Research Services' Medical Arts Goldberger; vice president, Dl·. and Photography Brnnch, designed NIH employees are being asked Summer hours for the Na­ Robert Adelstein; treasurer, Dr. the report. to volunteer as tutors in special tional Library of Medicine- Alan Pete1·kofsky, and secretary, The Federal Editors Association subjects for high school and college 8 :30 a.m. to 5 p.m., Monday Dr. Alan Schechter. and Government Information Or­ students who will be working here through Saturday-will con­ Newly elected members of the ganization recently combined to during the summer. tinue through Sept. 3. Board of Directors are Dl'S. Gilbert make the NAGC, a national organ­ Tutors are needed for such sub­ The Library will be closed Ashwell, Edwin Becker, and Ruth ization for information employees. jects as chemistry, algebra, trigo­ Labor Day weekend, before Kirschstein. Last June Reseai·ch Advances nometry, biology, physics, calculus, resuming its regular hours, and geometry. 8:30 a.m. to 9 p.m., Monday For information concerning 1975 received a first place award For further information, call through Friday, and 8:30 a.m. membership in the FAES or re­ from the Society for Technical Phyllis Copeland or Linda Cun­ to 5 p.m. on Saturday. garding use of the new center, call Communications in the Technical the Foundation office, 496-5272. Reports Category. ningham, Ext. 62146. June 29, 1976 THE NIB RECORD Ultrasonic Scanning Technique Can Aid Dr. Greenhouse, Newest Grants Associate, Was In Detection of Stroke-Prone Persons On U. of Cal. Faculty Research toward a safe, simple procedure for detection of the poten­ Dr. Gerald Greenhouse, former tial stroke victim so that stroke may be prever,ted was described by a assistant professor with the Uni­ University of Cincinnati researcher at the American Heart Association's versity of California, Irvine, has recent Stroke Conference in Dallas. joined the Grant.-; Associates Pro­ Di·. Charles P. Olinger, associate professor of neurology at the Uni­ gram fo1· a year of training in versity of Cincinnati College of health science ad­ Medicine, repoded on evaluation of on a TV screen, the reflecting ministration. a new ultrasonic scanner for view­ "echoes" show the artery wall. D1·. Greenhouse ing the interior of the carotid ar­ Blood coursing through the artery has been with the tery, the main arte1·y leading to appears black; other tissues ap­ University of Cal­ the brain and chief site of obstruc­ pear white or grey. iforni2.'s depart­ tion resulting in strokes. Obstructions or thickened areas ment of anatomy Dr. Olinger is principal investi­ appear as protrusions into the since 1972. Dudng , gator on a research contract from black area. Some large deposits this period, he re­ the Devices and Technology Branch, often look like boulders jutting ceived two research National Heart and Lung Insti­ into the black area, Dr. Olinger gr:ants from the tute, on the development and use commented. Dr. Greenhouse Orange C O u n t y of ultrasound as a diagnostic "In the scanner's present stage Medical Research Committee and screening device. of development we can pick up the Damon R unyon Memorial Can­ Irene Robinson waa honored by Since 1973 Dr. Olinger has been plaque of a millimeter or less in cer Fund, and two research con­ friends, co-workers, and her husband developing a scanner with a team the image, and can obtain several tracts from the U.S. Air Force. Horry at a recent retirement porty, of engineers headed by Dr. William hundred views in a matter of sec­ Ile was also concerned with two A model of the Capitol marked her Glenn, Dr. Anant Nigam, and Ken onds. We are also able to differ­ training grants, one awarded in 12 years on the staff of the Office of Solomon of the New York Insti­ entiate between hard and soft tis• 1972 to the department of biological Legislative Liaison, Notional Institute tute of Technology's Nova Univer­ sues." sciences, the other awarded to the ef Child Health and Human Develop­ sity in Ft. Lauderdale, Fla. Endoscopic Movies Inform faculty research facility in 1975. ment. During her 22-year Federal He received a B.A. degree from career, Mrs. Robinson received several Because treatment, prognosis, During his presentation at the Queens College in 1964, and the commendations and a tribute in the and ultimate prevention of stroke Stroke Conference, Dr. Olinger depend on the ability to make a Ph.D. degree in developmental bi­ June 9 " Congressional Record." displayed endoscopic movies of the specific diagnosis, Dr. Olinger has interiors of carotid arteries to il­ ology from the City University of great hope for the scanner as a lustrate how ultrasonic scanning New York in 1969. While at Lister Hill Center Lets safe, simple alternative to angio­ can provide information about the CUNY, he was a NIH predoctoral Contract on Simulation graphy, the present method of de­ artery wall that angiography can­ trainee in teratology. I In Medical Education tecting and determining the nature not detect. Held Fellowships o:f atherosclerotic plaque, or build­ Simulation techniques are in­ "Buildup in an artery wall in As a postgraduate, he held an ~ up which forms on the artery wall. many ways compa1·es to rust and KIH postdoctoral fellowship at the creasingly important in medical Angiography requires hospital­ education. By giving the student corrosion in water pipes. When Massachusetts Institute of Tech­ ization of the patient, puncturing the buildup becomes thick enough nology and was a postdoctoral fel­ experience in dealing with situa­ the artery to inject X-ray contrast tions that are as close as possible to block the artery, blood flow is low at the University of Geneva, fluid, and a complicated series of inadequate to supply the brain, and Switzerland. to those that might be encountered X-rays. in later practice, simulation offers strokes or stroke symptoms occur. Dr. Greenhouse's research intei·­ obvious advantages to both stu­ Procedure Hos Risk "If a piece of the buildup breaks ests include the etiology of con­ dents and teachers. The procedux·e is not without loose from the wall and travels to genital malformations, biochemical The National Library of Medi­ risk, and because of its relative the brain, a stroke is likely to oc­ events during oogenesis and early cine's Lister Hill National Center complexity cannot be used as a cur. When the plaque is u1cerated, embryogenesis, and the translation for Biomedical Communications screening procedure or be repeated clots can form at the site and block level contrnl of protein synthesis. has awa1·ded a contract to the Of­ easily for follow-up of increased the artery or break loose, causing Re is the author and co-author fice of Medical Education, Re­ plaque buildup to determine a stroke," Dr. Olinger said. of 25 papers and abstracts in his search, and Development at Mich­ whether drugs or diet can reverse "While present research is fo­ field. iga1'l State University to gain a the process. cused on the carotid artery, it clearer concept of the role of sim­ Ultrasound in many ways ap­ should be possible to achieve good ulation in medical education, in­ proaches the ideal diagnostic tool, results on other major arteries," DR. HEGYELI cluding: Dr. Olinger believes. Noninvasive, Dr. Olinger noted. (Contim,ed from Page 1) • A detailed listing of some 180 nontraumatic, and not requiring Detecting, measuring, and visu­ ficial Heart Program in 1969, she ongoing and completed projects in hospitalization, ultrasound pe1·mits alizing the degree o:C atheroscler­ worked as a research scientist at simulations. visualization of soft tissue struc­ osis present in the carotid arteries the Institute for Muscle Research, • A listing of organizations tures that cannot be seen well-or and other peripheral blood vessels Woods Hole, Mass., and as senior funding reseai·ch or development at all-radiologically. are also being studied by six other reseai·ch pathologist in charge of in creating, using, or evaluating The equipment is relatively in­ contractors, using the new ultra. the Cell Biology Laboratory, Ba­ simulation in medical education. expensive compared with X-ray, sonic technology to develop non­ telle Memorial Institute, Colum­ • An annotated bibliography on and poses few operational problems invasive instrumentation for diag­ bus, 0. simulation. to a trained technician. nosis and medical research. Lost Post Noted • A survey of faculty needs and Two other contractors are using In 1971 she moved to the OPPE preferences for simulation, and an Dr. Olinger said the basic design consists of an imaging probe con­ novel magnetic and X-ray imaging where in 1973 she became chief, evaluation design for future test­ techniques as other approaches to Program Development and Evalua­ ing of simulation effectiveness. taining a large aperture transdu­ cer and a reflective scanning me­ this important problem of diagnos­ tion Branch, and served as acting To obtain any of these documents chanism sealed in a water cham­ ing atherosclerosis. director, OPPE, this past year. as they become available, write to ber with a transparent membrane Dr. Harold Wooster, Lister Hill 13 Million Hove Poor Hearing, According to NCHS Report Center, NLM, 8600 Rockville Pike, at one end. The probe is moved by hand along the course of the More than 13 million Americans different data collection procedures Bethesda, Md. 20014. artery. aged 3 years and older suffer im­ and a change in one question. It is difficult to see the past in Ultrasonic waves penetrate the paired hearing- an increase in the The figures showing a jump of true perspective: the yea1·s seem body tissue and bounce back at number of affected persons since a 3.8 million persons suffering im­ almost on one plane like images varying intensities when the beam 1962-63 survey- but most of the paired hearing in one ear are part in a kaleidoscope.-Sir John Bland­ hits skin, fat, muscle, bone, or ar­ increase, the National Center for of the results from the 1971 Healt}. Sutton. tery wall. Converted to a readout Health Statistics says, is due to Interview Survey. THE NIH RECORD June 29, 1976 P age 5 GUIDELINES Dr. Raymond E. Shapiro (Continued from Page 1) may be pi-evented or modified. Named Director; NIEHS , • I n the future this technology may produce in microorgani8ms Toxicology Coordination medically important compounds for Dr. Raymond E . Shapiro has the treatment and control of dis­ been appointed director for Toxi­ ease. cology Coo1·dination for the Na­ There are risks in the new re­ tional Institute of Environmental search as well as potential bene­ Health Sciences. fits. Microorg3nisms with trans­ "Dr. Shapiro's major role at planted genes---called "chimeras" NIEIIS." said Di·. David P. Rall, -may prove hazardous to human Institute Director, "is to serve as a or other form8 of life. Thu8 spe­ senior advi~o1· to me on toxic sub­ cial provisions are necessary for stances, especially chemical com­ ~ their containment. pounds, as they affect human health." The NIH Guidelines establish Dr. G. Donald Whedon, Director af the Nationol Institute of Arthritis, Me­ carefully controlled conditions for tabolism, and Digestive Diseases, addresses more than 100 guests at the He will maintain continuing li­ the conduct of eJ{periments involv­ lnstitute's recent 25th anniversary dinner at the Naval Medical Center. The aison with othe1.· Government agen­ ing t he production of such mole­ head table included (r to fl: Dr. DeWitt Stetten, Jr., NIH Deputy Director cies, private industries, and non­ cules and their inset"tion into or- for Science and former NIAMDD director of Intramural Research; his wife Government research organiza­ • ganisms such as bacteria. These Dr. Marjorie Stetten, NIAMDD researcher, and Dr. William H. Sebrell, Jr,, tions. This will permit him to de­ Guidelines replace the recommen- Director of NIAMDD from its ince ption until he was appointe d NIH Director termine what work is being done, • -. dations contained in the 1975 in October 1950. to identify priorities, and to pin­ Summury Statement of the Asil­ point available resources. onuu- Conference on Recombinant Augmented with consultants rep­ cedures used in any recombinant It will also help him to antici­ DNA Molecules. The latter would resenting Jaw, ethics, consumer af­ researcb they report on. pate changes in focus on new prob­ .., have permitted research under less fairs, and the environment, the Ad­ Dr. William Gartland, who will lem areas, recommend appropriate strict conditions than the NIH visory Committee to tho Director NIEHS action, and advise the In­ r Guidelines. head the NIH Office of Recombi­ was asked whether the proposed nant DNA Activities, left June 23 stitute on new toxicological re­ The chrnnology leading to the Guidelines balance responsibility for Geneva to brief various inter­ search needs. -,. present Guidelines is described in to protect the public with the po­ national health and scientific or­ Dr. Shapiro will also serve as detail in the NI H Director's de­ tential benefits through the pur­ ganizations with responsibility in e,l{ecutive secretary for the HE W cision document. suit of new knowledge. this area and to meet with the Committee to Coordinate Toxicol­ Issues Aired 16 Months The many viewpoints CJ{pressed WHO Advisory Committee on Med­ ogy and Related Programs. Dr. at this meeting wel'e considered by Dr. Fredrickson reached his de- ical Research. Rall serves as the Committee's the Director in making his decision. chairman. ~ cision on the Guidelines after ex­ Europe an Officials Briefed Dr. Fredrickson emphasized, how­ Dr. Shapiro was formerly with tensive scientific and public airing ever, that NIH will continue to Dr. Cartland will also brief of­ · of the issues during the 16 months the Epidemiology Unit of the Bu- deliberate issues raised by the sci­ ficials at t he European Molecular which have elapsed since the Asil­ 1·eau of Foods, Food and Drug entific community and the public Biology Organization and in Great Administration. omar Conference. on this type of research. Britain. The Guidelines have also The issues we1·e discussed at He graduated from the College Experime nts Identified been sent to all science attaches of public meetings of the Recombinant foreign embassies located in Wash­ DNA Molecule Program Advisory The N I H Guidelines identily ex­ ington and to ~cience attaches in ·· Committee (Recombinant Advisory periments which are not to be per­ U.S. embassies. Committee) and the Advisory Com­ formed at the present time. For _. mittee to the NIH Director. Dur­ pel'missible experiments, the Guide­ ing this period, the Recombinant lines define different levels of phys­ NIH Visiting Scientists " Advisory Committee extensively ical and biological containment, Program Participants debated three different versions of and classify containment criteria the Guidelines. for different kinds of recombinant 6/1-Dr. Bruna Pegora1·0, DNAs. Italy, Environmental Mutagenesis Branch. Sponsor: Dr. William In the combination specified, Sheridan, NJEHS, Research Tri­ these measures are designed to pro­ tect wol'kers and the environment angle Park, N.C. while permitting research to pro­ 6/ 1 - Dr. Daniela Saggioro, ceed. Italy, Environmental Mutagenesis The Guidelines also define the Branch. Sponsor: Dr. Shiu Hu­ responsibilities of investigators, ang, NIEHS, Research Triangle institutions where the research is I'ark, N .C. While with FDA, Dr. Shopiro worked conducted, and NIH staff and ad­ 6/ 1-Di·. Tohru Yoshioka, J apan, closely with the HEW Committee to visory committees. Laboratory oi Neurobiology. Spon­ Coordinote Toxicology and Related Dr. Fredrickson noted that NIH sor: Dr. Ichiji Tasaki, NIM:H, Bg. Programs and was chairman of the recognizes a special obligation to 36, Rm. 1002. Committee's Asbestos Subcommittee. disseminate the Guidelines as 6/3-Dr. Flavio Moroni, Italy, widely as possible. Accordingly, of the City of New York, and re­ Laboratory of Preclinical Pharma­ ceived his Ph.D. from Ohio State the Guidelines will be sent to all cology. Sponsor: D1·. Erminio of the approximately 25,000 NIH University. Costa, NIMH, WAW Bg., St. Eliz­ Previously, Dr. Shapiro was with George Titrington (r), chief, Con­ grantees and contractors. Major abeths Hospital, Washington, D.C. societies of professionals working the U.S. Soils Laboratory in Belts­ struction Engineering Branch, Di- 6/ 6-D1·. Nagaswamy Krishnan, ville, Md., and with the Rotham­ ~ vision of Engineering Se rvices, re­ in this area will also be asked for endorsement. India, Adult Psychiatry Branch. steKentucky. erage extends for 1 year after the similar company or institutional Regents Professor at the University of , employee leaves NIH, and is avail­ blood replacement programs al­ California, Be rkeley, won the award able whether or not the employee ready require employees to make NIH Grants for Training, for his pape r on regulation and bio• I is a donor at the Clinical Center annual donations to receive cov- Construction, Libraries synthesis of steroid hormones, em­ Blood Bank. erage. phasizing predictive aspects for yet Although the Blood Bank has According to Dr. Richard Davey, Listed in New Volume undefined congenital disorde rs. thus far been able to fill all re­ acting chief of the Blood Services The publication, National Insti­ quests for family coverage, increas­ Section, CC, the preferred solution tutes of Health Grant.q jor Train­ tracts, and awards are prnpared ing demands for blood have se­ would be increased numbers of ing, Construction, Med-ical Libra­ annually by the Division of Re- ~ verely strained existing resources. NIH employees who donate blood ries, Fisc(tl Year 1975 Funds, has search Grants, based on records Less than 20 percent of NIH em­ so that patient care and employee been issued. contained in the NIH central re- ' ployees have ever donated blood, 1·eplacements needs can be met The volume includes 3,891 train­ ord system (IMPAC). ing grants, traineeships and fel­ and an even smaller percentage without difficulty. Separate listings of research lowships, cancer research facilities could be considered "regular" The Blood Bank donor recruit­ grants and contracts for fiscal year construction, and medical library donors. ment staff-Jane Kendall, Anna 1975 were released earlier. These valued donors are provid­ Brown, Elaine Collins, and Jimmie grants awarded by NIH compo­ ing blood not only for patient earn Driscoll-are now developing new nents from fiscal year 1975 funds Single copies of DHEW Publica· , at the CC but for employee replace­ methods for expanding employee and from fiscal year 1974 released tion No. (NIH) 76-1043 are avail­ ment needs exceeding 800 units a donor rolls. funds. able at no charge from DRG. year. To volunteer as a blood donor It also contains listings of grants Multiple copies may be pur• Since employee donations cannot and contribute to the patient care by area, program director, and the chased at $1.40 each from the Su• always meet these demands, the and employee family coverage ef­ organization having professional perintendent of Documents, U.S. Blood Bank has had to rely on the forts, call for an appointment at 1·esponsibility fo1· the work. Government Printing Office, Wash· Washington Chapter of the Amer- the Blood Bank, Ext. 61048. Listings of NIH grants, con- ington, D.C. 20402. THE N m RECORD June 29, 1976 Page 7 Science Writers Seminar Held on New Research in ~ ell Surface Receptors Three researchers who discussed their current studies on cell sur­ face recepto1·s at a recent Science \Vriters seminar here were intro- • duced by Dr. Edward Korn, NHL!. Before introducing the speakers, Dr. Korn, chairman of the N I H Inter-Assembly Council of Assem- 1' blies of Scientists, explained the background and importance of cell ~ surface receptors. ,. Dr. Julius Axelrod, NIMH, ' chaired the seminar. Ho discussed recent nem·otransmitter discoveries Although many of her duties keep her tied to the A Wing the bulletin board up to date (cl with the fascinating that have Jed to more effective information desk (fl-giving directions, scheduling con- variety of advertisements submitted monthly by HIH 'ers, treatn1ent of Parkinson's disease ferences, calling taxis, locating NIH personne l, ond and organizes the Bldg. 31 Car Pool locator (r) near the fJ and schizophrenia. answering 1001 questions- Mrs. Willcoxon also keeps cafeteria-on increasingly popular service for commuters. Dr. Candice B. Pert, also of able to stay abreast of the endless NIMH, ~aid that opium receptors VIP's, Transit Schedules, Lost and Found-­ changes in personnel, position °" in the brain may function as na­ titles, and room assignments. Now tural pain killers. Mrs. Willcoxon Takes All in Her Stride she is the first to know who is She indicated that the role of Over the past 10 years from her vantage point at the "nerve center" what, and where. these opium receptors is unclear at of Bldg. 31-the A Wing information desk-Ethel Willcoxon has seen Mrs. Willcoxon says her life ~ present, but they apparently ac­ a multitude of people come and go, as well a·s many human dramas. seems to fall into 11-year periods, cept morphine-like peptides to A routine day includes answering quel'ies from the telephones in the length of time she held previous function as the body's natural opi­ the B and C Wing entrances to jobs at the Home Loan Bank ates. Bldg. 3l, which are connected to desk, and Mrs. Willcoxon has be­ Board, the Maritime Commission, Dr. Jesse Roth, NI AMDD, point­ the A W ing information desk. come an expert at helping people and War Department. Then she ed out that there is a relationship She also assists in making or figure out how to get where they're was home for 11 years with her between obesity, insulin, and in­ changing reservations for persons going one way or another. son- now working in the NI H sulin receptors. He noted that attending conferences in Bldg. 31 That includes job hunters, who Federal Credit Union- and her while obese people have high levels whose plans may suddenly change may get lost in the maze of offices daughter, who just graduated from of in~ulin, they often have few as meetings end ahead o~ time 01·- in Bldg. 31, prospective Clinical high school. 1 receptors-an example of hormone more often-run over time. Center patients who are mistakenly Now she likes the variety and resistance. Copes ~ith Predicaments . . brought to Bldg. 31, and messen- n umber of people she meets-even, Cutting food intake will quickly A _typical Pt?blem demandmg 1m- gcrs delivering grant applications sometimes, celebrities like Danny raise the number of receptors and me~1ate solution was the recent who must find a particular office or Thomas. "I found I like being on lower the insulin level, according arrival - unannounced - of two administrator before a deadline. my own- and I like coming to work to Dr. Roth. Congres~men ,~ho wan~d to see Occasionally emergencies arise­ every morning,'' she says. The seminar is one in a series an Institute Director nght away electricity isn't working in a con. So much, in fact, that she en­ presented by intramut·al scientists but_ couldn't fi1:1d a pl_ace to park ference room, so Building Services joyed her stints at the Open Houses • of NIH and the Division of Public theu~ ca1·s. With typical aplomb, must be called last year and this, when she volun­ Mrs. Willcoxon arranged with the · Information. guards for the cars to be left in One hanied man arrived late for teered to stay on duty at her reg­ reserved spaces, then directed the a meeting, jumped out of a taxi, ular post-later receiving a com­ mendation letter from her boss, -- Accumulated Sick Leave th and only later remembered that he legislators to e Director in ques- had left his brief case behind. Af­ Daniel Kenney, who also praised Is Valuable 'Insurance' tion. Numerous times she has called ter he returned to New York, and her recently after she returned a The average Government em- tow trucks for disabled cars, ambu- after a week of calling cab com­ 2.2 carat diamond ring to its owner .. ployee could not afford to buy sick­ lances for visitors or employees panjes, Mrs. Willcoxon located the and refused to accept a reward. ness and accident insurance that who sudenly become ill, and taxis m issing item-and received a note would pay his or her full salary for dignitaries in danger of miss- and candy as a t hank you. for a year and a half at, say, age ing their airport connections. She also has a "secret admirer" • 50. On one occasion she managed to who often leaves flowers on her But that is exactly what sick 1 reunite a family which had missed desk before she arrives in the leave offers if it is conserved for connections and mistaken direc- morning. And numerous people use in a real emergency. tions, "'ith wife and children wait- stop to say hello as they enter and Proper use of sick leave--earned ing one place and the man of the leave the bui!ding--or to ask, at the rate of 13 days a year for family cooling his heels in another "Have you seen X come in yet? full-time employees- is encouraged. building. Has Mr. Y been past recently?" However, if an employee is fortu­ Fortunately, not all these inci- The eontacts with people keep nate and can permit sick leave to dents happen in one day, but Mrs. Willcoxon enthusiastic about accumulate, the benefits mount: 10 yeara- 130 days or 1040 )lours through it all, Mrs. Willcoxon re- her job. When she first came to 15 .. 195 " ,. 1560 " mains calm, collected, gracious, and NIH 12 years ago, she was a clerk­ 20 260 " " 2080 25 326 " " 2600 .. very helpful. "I take care o.f any- typist in the National Institute of 30 " 390 " .. 3120 thing l can,'' she says-and backs Dental Research. As one gets older, extended ill­ the statement up with action. Someone suggested that she The University of Virginia School of ness is more likely to strike. Used Her worst moment, she says, might prefer the information desk Medicine and its alumni paid tribute eonservatively, sick leave "insur­ came somP years ago when a post, but she says she wasn't sure to Dr. Seal (r), t-UAID acting de puty ance" will give the employee ben­ stranget suddenly approached her she would like it until she had tried director, with John R. Seol Doy on efit.~ he or she would not otherwise desk, berated first his mother, who it for a while. the Charlottesville campus on June 4. have, and will prove invaluable was accompanying him, then Mrs. And, in fact, the initial weeks In the afternoon, o program on in• when the need arises. Willcoxon, and finally became quite were tough-especially until she fectious diseases was held with col­ Another advantage, accumulated violent. She managed to call the succeed in accurately updating leagues sketching research highlights sick leave at time of retirement guards, who arrived "in seconds." the desk's central directory of NIH ond stressing Dr. Seal's prominent role gives the employee an additional Metro and shuttle bus schedules employees. When she first arrived, in them. Dr. Robert Chonock, HIAIO, amount of annuity. are available at the information none of her predecessors bad been congrot'ulotes Or. Seal. Page 8 June 29, 1976 THE NIH RECORD

On June 21 and 22, meetings were held in the Masur Auditorium on the and the Deportment of Defense. A press briefing (above) was given Monday at results of nationwide swine flu vaccine trials in 5 ,000 persons, Porticiponts noon in the Clinical Center lobby by (center, I to rl Dr. Poul D. Parkman, represented the Notional Institute of Allergy ond Infectious Diseases Bureau BoB, Dr. John R. Seal, NIAID, ond Dr. David T. Karzon, Vanderbilt University. of Biologics/Food and Drug Administration, the Cente r for Disease' Control, FLU VACCINE Fed. Work Force Shifts; NLM Aids Study of 1918 Flu (Continued from Page 1) HEW Gain Is Reported Epidemic and Peace, 1918, a work by Alfred W. Crosby, Jr.- J late August or early September. During the past 5 years a "sig­ supported in part by a fellowship If further studies, now being plan­ nificant shift" has occurred in the from the National Library of Med­ ned, result in the development of Federal civilian work force, accord­ vaccines suitable :for younger age icine-has made a recent (and ing to a report by the Congres­ timely) appearance, owing to cur­ groups, these preparations might sional Budget Office. become available in the late fall or rent interest in swine influenza. The distribution of Federal ci­ early winter. Published in March by Green­ Vaccine for adults will be pre­ vilian employees finds a decline in wood Press of Westport, Conn., the pared in two forms at dosages to the Department of Defense. illustrated, 337-page book ($17.50) < be set shortly by the BoB. A mono­ In 1970 DOD had 41 percent of is a history of the 1918 "Spanish valent vaccine which protects only the Federal civilian work forne. influenza" epidemic, whose toll was against swine flu will be offered to In 1975 it had 37 percent. The twice as great as combat deaths all normal adults. actual number of civilian employ­ on all fronts during World War I. ees at DOD has decreased by 12.7 Elderly Receive Bivalent percent since 1970. A bivalent preparation, effective The report says "significant per­ against both the swine-like virus centage" losses also have occurred and against A/Victoria-the influ­ in the Agency for International enza virus strain prevalent in the Development and the National U.S. last winter-will be given to 200years Aeronautics and Space Adminis­ the elderly (over 65) and to those tration. with underlying serious illness, and liberty "The reduction of 151,955 in ci­ such as heart disease or asthma. vilian employment in DOD since At a June 21 meeting held at 1970 has almost been matched by the Clinical Center and co­ still rings. a gain of 128, 657 by HEW, Labor, sponsored by NIAID, BoB, CDC, Treasury, ,Justice, and the Veter­ and the Department of Defense, in­ ans Administration." vestigators reported that, in im­ r munized adults, reactions and levels a second dose of the vaccines pro­ qf antibodies (protective blood Tu.kestockin America. ducing few side effects might be substances) were similar to those Buy US. Savings Bonds. given children who did not respond seen in the past when influenza vac­ adequately to the first dose. This cines have been given. and other studies are planned by Reported reactions affected from the two smaller doses of vaccines. Dr. David Karzon, Vanderbilt Uni­ 2 to 15 percent of the adult volun­ One of these two doses will be the Dr. Manning Feinleib, chief, Epidem­ versity, and by others from 10 in­ iology Branch, and chief, Field Epi- • teers studied, depending on the one selected for the national pro­ stitutions cooperating in the vac­ vaccine and dosage given. Most of gram. demiology Research Section, HHLI, cine studies in children. these reactions were minor and hos been named a Centennial Scholar Perhaps the most interesting Scope Is Unprecedented transitory. data resulting from the studies by the Johns Hopkins University Only one feve1· of 102° or g1·eater was the sharp demarcation noted Dr. John Seal, acting deputy di­ School of Hygiene and Public Health. was encountered among the more in antibody response between per­ rector of NIAID, who convened the He is olso clinical professor, deport­ than 1,350 volunteers that received sons bot11 before and after Asian meeting on June 21, called atten­ ment of community medicine and flu swept the world in the late tion to the fact that in exactly 2 international health, Georgetown Uni- , 1950's. months a total of 5,186 persons versity School of Medicine. Flu Search Citations Listed (including 1,204 children) had vol­ Since the influenza virus changed Tho National Library of unteered for the studies, had blood dented. drastically at that time, individuals Medicine has conducted a drawn, were immunized, and had Now that the code under which less than 23-24 years of age have search, No. 76-29, of scientific given a second sample of blood for the vaccine was administered has never encountered a virus resemb­ literature on swine flu in the antibody determination. been broken, all persons participat­ ling the new agent which is be­ MEDLINE base from Januai-y The more than 10,000 sera col­ ing in the trials will be notified 1966 through May 1976. lieved to be similar to ones circu­ lected were analyzed by one labor­ which vaccine they received and f. Single copies of the list of lating in the U.S. population from whether or not they now have anti­ 1918 through the 1930's, 40's, and atory at the Center for Disease 148 citations may be obtained Cont!'Ol in order to avoid differ­ bodies to the swine flu virus. free of charge by writing to: early 50's. Evidently, some "priming" of an ences in results which could be at­ lf they are not protected (for Literature Search Program tributed to differences in laboratory example, if they received a placebo Reference Section, NLM, 8600 individual is necessary for the swine flu vaccine to induce ade­ techniques. The size and scope of vaccine), they will be offered the Rockville Pike, Bethesda, Md. the test program was unprece- recommended vaccine this fall. 20014. quate levels of antibody. Some investigatoi-s suggest that * U.S. GOVERNMENT PRINTING OFFICE: 197:5-749•903/12.