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Abstract TOC 1386..1386 Abstracts |GA Thieme 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP Date/Venue: Congress president: September 1–5, 2019, Innsbruck, Austria Univ.-Prof. Dr. Hermann Stuppner Organizing societies: GA (Gesellschaft für Arzneipflanzen- und Naturstoff-Forschung e.V./Society for Medicinal Plant and Natural Product Research) in cooperation with the French Society of Pharmacognosy (AFERP) 1387 Editorial 1407 Short Lectures Monday, September 02, 2019 1388 Pre-Congress Symposia 1413 Regulatory Affairs Workshop 1388 African Research Workshop 1414 Short Lectures Tuesday, September 03, 2019 1391 Animal Healthcare and Veterinary Phytotherapy 1421 Short Lectures Wednesday, September 04, 2019 1395 Young Researchers’ Workshop 1425 Pre-Congress Posters 1400 Economic Adulteration of Botanical Ingredients 1432 Main Congress Poster Abstracts 1403 Abstracts of Plenary Lectures 1432 Poster Session 1 1506 Poster Session 2 1406 Abstracts of Key Lectures 1582 Authors’ Index 1407 Abstracts of Short Lectures 1592 Masthead Cover picture: Prof. Stuppner This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. 1386 Planta Medica 2019; 85: 1386–1590 Abstracts |GA Thieme Editorial ▪ Phytopharmaceuticals, dietary supplements, functional food, cosmeceuticals ▪ Medicinal plants and natural products in animal healthcare and veteri- th 67 International Congress and Annual Meeting of nary medicine the Society for Medicinal Plant and Natural Product The symposium started on Sunday, September 1st 2019 with four pre-con- Research (GA) in cooperation with the French gress events: the Young Researchers’ Workshop, the Workshop on African Society of Pharmacognosy AFERP Research Network and the one-day pre-congress Symposia on Animal Health- September 1-5, 2019 | Innsbruck, Austria care and Veterinary Phytotherapy as well as Economic Adulteration of Botani- cal Ingredients. The 67th International Congress and Annual Meeting of the Society for Medi- The scientific program of the Main Conference included 10 plenary lectures, cinal Plant and Natural Product Research (GA) took place in Innsbruck, Aust- 2 keynote lectures, 45 contributed short lectures and 492 posters. The Regu- ria, from September 1-5, 2019 in cooperation with the French Society of latory Affairs Workshop was held during the main conference and served as a Pharmacognosy AFERP. forum for industry to update on the latest trends in regulation of phytomedi- The main scientific topics of the conference were: cines and related areas. The meeting was also an excellent platform for exhi- ▪ Natural products chemistry bitors, who presented their latest products and services. ▪ Biological and pharmacological activities of natural products We would like to thank everyone who has made this GA meeting possible, in ▪ Analytical methods for quality control of Herbal Medicinal Products particular the members of the Organizing and Scientific Committees, as well ▪ Metabolomics and molecular networking as the representatives of the PCO Tyrol Congress. We are also grateful to the ▪ Identification and authentication of plant material University of Innsbruck for providing the meeting place and infrastructure for ▪ Ethnobotany and ethnopharmacology the pre-symposia and the get-together event, as well as the sponsors for ▪ Herbal drug formulations their financial support. ▪ Biosynthesis and biotechnology of natural products Last, but not least, we want to thank Thieme Publishers for publishing the ▪ Biodiversity and chemical ecology conference abstracts in Planta Medica. ▪ Clinical studies with natural compounds and Herbal Medicinal On behalf of the Organizing Committee Products Univ.-Prof. Dr. Hermann Stuppner This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. Planta Medica 2019; 85: 1386–1590 1387 Abstracts |GA Thieme Sciences, Università degli Studi di Milano, Milan, Italy; 3 Department of ABBREVIATIONS Environmental Science and Policy, Università degli Studi di Milano, Milan, IL: Invited lecture Italy; 4 Institute of Medical Research and Medicinal Plants Studies (IMPM), ISL: Invited short lecture Yaoundé, Cameroon SL: Short lecture DOI 10.1055/s-0039-3399631 In Cameroon, many medicinal plants, including spices, are used as herbal KL: Keynote lecture medicines and traditionally employed for the treatment of gastric diseases, in PL: Plenary lecture which oxidative stress is involved. The present work chemically characterizes and investigates the antioxidant and anti-inflammatory effect of hydro-alcoholic extracts of eleven Cameroo- nian spices at gastric level, focusing on Nuclear Factor (NF)-κB pathway. Pre-Congress Symposia Prepared hydro-ethanolic extracts were characterized by HPLC-DAD and GC/ MS analysis, then screened for their ability to inhibit tumor necrosis factor African Research Workshop (TNF)α-induced IL-8 and IL-6 release, in human gastric epithelial cells (GES-1 and AGS), assessing the involvment of NF-κB driven transcription. The antioxi- IL AR-01 Revisiting African traditional medicine dant activity of the extracts was evaluated as well. After a preliminary screening, Xylopia parviflora, Tetrapleura tetraptera, Dichrosta- within the 21st century context – past, present and chys glomerata, Aframomum melegueta, and Aframomum citratum extracts were future perspectives chosen for in-depth studies. They reduced in a concentration-dependent fashion 1,2 Authors Khalid S the cytokines release (IC50s between 0.19 µg/mL and 20 µg/mL) and the NF-κB Institute 1 Faculty of Pharmacy, University of Science & Technology, driven transcription (IC50s between 0.33 µg/mL and 20 µg/mL). They also sho- Omdurman, Sudan; 2 Faculty of Pharmacy, University of Khartoum, P.O. Box wed a highest antioxidant capacity measured by ORAC (range: 2.52–11.88 μM 1996, Khartoum, Sudan Trolox Eq/g of extract), FRAP (range: 40.23–233.84 mg gallic acid Eq/g of ext- DOI 10.1055/s-0039-3399630 ract) and Total phenols (range: 8.96-32.96% mg gallic acid Eq/g of extract) assays. Chemical analysis suggested that their secondary metabolites (androste- Although Africa appears culturally heterogeneous with thousands of distinct none, chlorogenic acid, pimaric acid, catechin, caffeic acid and its derivatives, tribes, dialects and languages, it is united by a common thread of traditional 4ʹ,5,7-trihydroxyflavanone, gingerol, shogaol, paradol and gallotannins) could medical systems and spiritual attributes. African biodiversity, coupled with potentially justify the biological properties observed. this deeply rooted African ethnobotanical heritage, has already contributed a Results obtained from this study showed that the extracts reduce oxidative number of novel chemicals entities resulting in potent pharmacotherapeu- stress and inflammatory markers by scavenging free radicals and impairing NF- tics, and Africa still remains a promising untapped reservoir for the discovery κB signaling at gastric level. However, other molecular mechanisms cannot be of more diverse chemical entities. African flora have already demonstrated excluded, and further studies are needed to better clarify their biological their chemical diversity by providing a series of novel chemical entities [1]. activities. The pharmacotherapeutic potential of the African biodiversity has not yet been realized since much of the research carried out is fragmented with little or no SL AR-02 Chemical composition and in vitro focus on drug discovery. African researchers are not only challenged by commu- investigation of the antibacterial activity of nicable and non-communicable diseases encroaching upon the continent, but identified compounds from fungus-growing termites they are also confronted with meagre financial resources, poor infrastructure and non-accessibility to modern technological platforms which are crucial ele- Macrotermes bellicosus ments for drug discovery. While the African continent is virtually considered as Authors Mahdi DH1,5, Hubert J2, Schubert A3, Vissiennon Z1, Ahyi V1, the epicentre of pathogens endemicity, the African scientific community is very Nieber K4, Vissiennon C5,6 poorly represented in setting the research agenda and priorities. Institute 1 IRGIB Africa University, Inter-Regional University of Industrial The recent initiative of GA to streamline African research is undoubtedly a move Engineering Biotechnologies and Applied Sciences, Cotonou, Benin; 2 Institut in the right direction, provided that concerted and concomitant efforts are de Chimie Moléculaire de Reims (UMR CNRS 7312), SFR CAP’SANTE, made to maintain a sound scientific capacity in Africa. Such efforts are a major Université de Reims Champagne Ardenne, Reims, France; 3 Fraunhofer IZI, requirement for stopping the brain drain, further consolidate the African ethno- Institute for Cell Therapy and Immunology, Leipzig, Germany; 4 University botanical heritage and building a critical mass of young African scientists to gua- ofz Leipzig, Institute of Pharmacy, Leipzig, Germany; 5 University of Leipzig, rantee ownership and sustainability of long-term control programmes. Medical Faculty, Institute of Medical Physics and Biophysics, Leipzig, This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. References [1] Khalid, SA. Natural products-based drug discovery against Germany; 6 Repha GmbH Biologische Arzneimittel, Langenhagen, Germany neglected diseases with special
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