® SigmaPlot 11 Features Error bars SMOOTHING "Picking from Column" Option • Mean, Median, First and Last values for symbols 2D & 3D Smoothing Routines • Enter colors, patterns, symbols, line styles, tick mark SigmaPlot 11 • Standard deviation, Standard error • Negative exponential intervals, tick labels and more directly into your worksheet GRAPHING FEATURES • 10th, 25th, 75th, and 90th Percentile • Running average to customize your graph the way you want. Transforms 2D • Min and Max • Loess and "picking from column" allow you to create data • Vector - 2 Types * • 95% or 99% confidence • Running median dependent color gradients, symbols and sizes. • Area Plots - 4 Types • Calculate error bars from replicate values across rows • Bisquare Automate Routine and Complex Tasks ® • Scatter - 14 types • User-defined upper and lower error bar values • Inverse square • Visual Basic compatible programming using built-in • Line - 4 types • One way, two way and asymmetric error bars • Inverse distance (for 3D smoothing) macro language interface • Scatter and Line - 10 types • Percentile method: 2-types • Macro recorder to save and play-back operations • Step - 8 types TRANSFORMATIONS Multiline Text Editor • Full automation object support - use Visual Basic to SigmaPlot 11 • Vertical Bar - 2 types, Vertical Grouped Bar - 2 types • Control font, size, style, color, Greek, multiple levels of Quick Transforms create your own SigmaPlot-based applications • Horizontal Bar - 2 types, Horizontal Grouped Bar - 2 types superscript & subscript, 360 degree rotation, left, right • Perform quick mathematical transforms provided in a • Run built-in macros or create and add your own scripts • Vertical, Stacked Bar & center justification, and line spacing function palette • Add menu commands and create dialog boxes The Standard for Data Analysis • Horizontal, Stacked Bar • Automatic Updating of multiple transforms in worksheets * • Toolbox menu: helpful macros appear as a separate • Box - 2 types Grids and Fills menu item • Polar - 3 types • Control of color, line type, thickness, and display of major & Mathematical Transforms • 36 probability density and cumulative transforms * • Export graph to PowerPoint Slide • Contour, line and filled - 2 types minor grids in X, Y, & Z direction • New 'Insert Graph to Microsoft Word' Toolbox macro • Histograms - 6 types • Control of pattern and edge color, pattern style, pattern • Histogram • Normalize ternary data • New keyboard shortcuts in the Graph Properties and most and Technical Graphing • Ternary - 3 types density, and edge thickness Symbols keyboard shortcuts in the worksheet • Bubble • Interpolate 3D mesh Reference Lines • Sorting Windows Application • Pie • Control mean, standard deviation, standard error, user-defined Analyze and Graph your Data • Fast Fourier transforms with filters • Excel, Word and PowerPoint for Office 2000 and • Control Charts constants, 95% and 99% confidence intervals • Needle • Lowess smoothing support ToolTips • Up to 5 horizontal or vertical lines • Differential equations • Tips and Tricks at startup • High-low-close, Range, Quartile • Control of color, line type, and thickness • Quadrant • Data to RGB-color transform • Full 32-bit implementation with Unparalleled Ease and Precision • Population Drop lines • Trigonometric and algebraic functions • OLE 2 container and server • Display in any or all X, Y, and Z directions • Random and Gaussian random number generation • Use Excel worksheets inside SigmaPlot 3D • Range, accumulation, precision, and more • Controls have bitmaps to give feedback about selections Designed specifically to meet the needs of professional researchers • Select any object to make precise modifications * Legends • Transforms are now kept in notebook files as JNB files for • Right mouse button property editing • Automatically interpolate unordered 3D data • Automatic or manually created easier organization of transforms; create transform libraries; • Selection of objects on graph page • Multiple, intersecting plots with hidden line removal, • Legends for regressions, confidence, and prediction intervals associate Transforms with data sets • Full precision and date/time Microsoft Excel copy and paste smooth or discrete shading, transparent or opaque fills, • Turn on and off lines and symbols • Protect and track changes to transforms for 21 CFR Part 11 Many scientists have struggled to create the exact technical graph to best and light source shading • Place line and symbol before or after text Microsoft Office Integration • 3D rotation • You can open Excel spreadsheets directly inside Function Plotter GENERAL FEATURES SigmaPlot, allowing you to use the many features represent their research results using spreadsheet and data analysis programs. • Perspective preview • Plot 2D and 3D functions • Scatter Large, Scientific Worksheets Excel offers. Use in-cell formulas and other Excel data • Over 100 2D and 3D built-in, graphically-illustrated analysis tools on your data. Scientists like you designed the exact solution – SigmaPlot. It delivers a full • Bar equations • 32,000 columns by 32,000,000 rows • 3D line - trajectory • Handles numeric, text (categorical), and date & time data • One-click access to directly launch SigmaPlot from • User-defined parameters, scale and range Microsoft Excel range of graphing options and over 100 2-D and 3-D graph types. And flexible • Mesh - with or without contour projections • Customize the SigmaPlot library of functions or create your own • Data sorting • Contour • Plot functions on new or existing graphs • Rename, insert and delete rows and columns IMPORT & EXPORT OPTIONS • Waterfall • Plot multiple different parameter values simultaneously • Insert color, symbols, line styles and bar patterns Import editing options give you more control over the look and design of your graph Create Graphs Easily • Select line properties for each function • Independent graphically adjustable row height and • Directly import SAS data sets (.sd2 and .sas7bdat files) • Pre-formatted Worksheets: Use graph and worksheet dis • Equation Solver: solve equations or functions containing a column widths • Directly import Minitab data sets (.mtw & .mpj files) than you’ll find in other graphing packages plays to design the graph. Entering new data immediately single independent variable and any number of parameters • Missing data handling • Open Axon Binary, Axon Text, ASCII Plain, Comma and displays the results * • Data point sampling general import filter, 1-2-3T, Symphony T, Quattro T, Excel, Graphs Created Through Transforms • Program Startup Screen: helps both first time users or • Graphical feedback of current curve and datapoint dBASE E, DIF, all SigmaPlot files through SigmaPlot 9.01, • Gaussian cumulative distribution power users start their workflow with easy access to previously • Text support of up to 256 characters SigmaStat files (all versions), SYSTAT, SigmaScan Pro, • Area - shading under and between curves Analyze your data quickly and easily used documents, quick Excel and Access database import; • Change the font type and grid colors Sigma Scan, SigmaScan Image, Mocha • Z plane design use older documents as templates for new work • Change font for worksheet • Import any ODBC compliant database • Kaplan-Meier survival • Graph Style Gallery: Save any graph with all graph • Multiple Undo • Run SQL queries on tables and selectively import • Frequency SigmaPlot provides all the fundamental tools you need to analyze your data - properties and add a bitmap image to the gallery to recreate • Format empty cells - formatted selected columns even if they information • Complex Control charts do not contain data complex graphs Export Exact Graphs and Data Analysis from basic statistics to advanced mathematical calculations. Run one of the • Graph Toolbar: select toolbar icon of the graph type and style DATA ANALYSIS FEATURES • More flexible column titles allow for duplicates and • SAS files (.sd2 and .sas7bdat files) you want to create a graph or to add additional curves to an numeric only titles • Minitab files (.mtw & .mpj files) Regression Wizard existing graph • Enhanced data/time recognition and more formats • ASCII Text, Tabbed, Comma, 1-2-3T, Excel, DIF, all • Linear and nonlinear regressions many statistical tests with ease, fit a curve or plot a function and get a • Graph Wizard: easy to use, step-by-step wizard for helping • Arrow-key functionality is similar to that of Microsoft Excel SigmaPlot files though SigmaPlot 9.01, SigmaScan Pro • 2, 3, 4, and 5-segment piecewise-linear models you select a graph type and pick data • Freeze Panes and print preview • PDF, PSD and HTML export of graphs and reports • Over 100 built-in, graphically-illustrated equations detailed report of the results in seconds. Apply built-in transforms to • Default graph settings: set preferences for graph options to • Multi-line editing - text wraps to fit the column while the • Marquardt-Levenberg algorithm with up to 10 Import Graphics Options create favorite graphs more easily row height automatically adjusts independent variables and 25 parameters • Load popular graphic file formats directly into SigmaPlot • Templates: create custom graph page templates to store for • Find and replace data perform calculations in one easy step and create special graph types. Solve • Define constraints, tolerance, step size and iterations graphic page easy accessibility and future use • Automatically determines your initial parameters SigmaPlot Notebook Manager • Import BMP, JPEG, GIF, TIFF, Cursor and Icon Files & many more • "Intersections" now supported for area fills equations or functions containing a single independent variable and any • Writes a complete statistical report to your SigmaPlot Notebook • Dialog-bar-based notebook manager has several states: • Automatically graphs your results on new or existing graphs docks, resizable, hide-able, summary information mode, Graph Publication Export Options number of functions. With SigmaPlot it’s all so simple! Technical Axes • Option to add 95 or 99% confidence and prediction bands to a etc. • Submission Assistant stores an extensible list of • Reciprocal (including Arrhenius) results graph • Can hold SigmaPlot worksheets, Excel worksheets, publication requirements and is used to double check • Weibull • Optional Reduced Chi-Square Regression weighting reports, regression wizard equations, graph whether exported figures meet standards of publication • Linear • Customize the SigmaPlot fit library or create your own fit pages, transforms and macros. and allows creation of customized output profiles • Log10 functions • Direct-editing of notebook summary information • Export an individual graph, a group of graphs and objects, Share SigmaPlot graphs on the Internet • Natural log SigmaPlot Report Editor or an entire page • Probit Dynamic Fit Wizard • Cut and paste or use OLE to combine all the important aspects • Different levels of resolution and color depths: PDF, EPS, • Logit • Solves difficult curve fitting problems by finding local and global of your analysis into one document. Choose from a wide TIFF, JPEG, EMF, BMP The SigmaPlot WebViewer allows you to automatically generate active Web • Probability fit solutions range of styles, sizes, and colors from any system font. • True color EPS vector and CMYK EPS export • Reverse • Selects many initial maximally-distant starting parameter sets • Export to most word processors • Compressed CMYK TIFF pages from your graphs or embed the objects within other Web pages. • Ternary percentage and ranks the resulting fits • Add decimal tabs, tab leader, true date/time fields • Publication Help: guides user through the complexities • Ternary unary • Shows the local minima with a Dynamic Fit Profile graph • Auto-numbering selecting the correct DPI, image size, file export format Viewers can explore the data used in your graphs and zoom, pan or print • Polar (both clockwise and counter clockwise) • Improved formatting ruler Publish as Web Page • Category (text data automatically binned into groups) Global Fit Wizard * Page Layout and Annotation Options • Export graphs as high-resolution Web objects • Time and date • Fit multiple data sets using shared parameters * • Direct graphic file import into graph page • WebViewer: free browser plug-in to view data used to create images at full resolution directly from their Web browser. • User-defined custom axis to create almost any scale • Real-time mouse-over XY and page coordinate feedback graph or print, pan and zoom in on graph without Axis Features Automatic Linear Regressions • Click-through accessibility to select and edit graph losing resolution • Control of display, thickness, color, range, and axis breaks • Up to 10th order with confidence and prediction intervals objects buried under other items • The WebViewer supports IE 4.01 or higher. A screen resolution • Offset axes and regression statistics • OLE 2 container and server JPEG file is automatically displayed for browser applications • Automatic titles • Automatic or manual legends and operating systems Column Descriptive Statistics Generated Save time and effort by automating complex • Multiple axes: Add Axis Wizard for creating multiple axes easily • True WYSIWYG Automatically SYSTEM REQUIREMENTS • Ticks: customize major & minor intervals, in & out orientation, • Multiline text editor and repetitive tasks top & bottom location, length, thickness, color, and tick mark • Multiple curves and plots on one graph Hardware selection from column to create custom axes STATISTICS • Multiple axes on one graph • Windows Vista: • Labels: customize prefix, suffix, numeric, and time & date • Over 50 of the most frequently used statistical tests to analyze • Arrange graphs with built-in templates 1 GHz 32-bit (x86) or 64-bit (x64) processor, Create macros in no time with SigmaPlot’s easy-to-use VBA-based • Axis breaks: customize symbol, thickness, color, length, scientific research * • Multiple levels of zooming and custom zooming 1 GB of system memory, I’ve owned and used SigmaPlot gap width, and post break interval • Advisor Wizard guides you through the process of choosing • Easily change the size and position of multiple selected 100 MB of available hard disk space for more than a decade and I love it. Symbol Types the appropriate statistical test * objects simultaneously to lay out and arrange graphs CD-ROM drive, macro language. Not a programmer? No problem - record macros by • Over 80 symbol types • Report generation that translates the statistics into plain and and other objects quickly 800x600 SVGA/256 color display or better We do both clinical and • More line types for line plots and line scatter plots, simple English * • Scale graph to any size • Windows XP or below: • Descriptive statistics * • Resize graphic elements proportionally with resizing graph point and click with the macro recorder. Use macros to acquire your free-form lines, boxes and ellipses 300 megahertz (MHz) processor, • 50 fill patterns for bar charts, box plots, pie charts, • Non-parameter tests: t-tests, ANOVA * • Alignment and position tools pharmacological research and * 256 MB of system memory, data, execute powerful analytical methods and create industry-specific area plots and free-form boxes and ellipses • One-way, two-way, three-way ANOVA • Draw lines, ellipses, boxes, arrows 100 MB of available hard disk space SigmaPlot enables us to analyze and • Edit font when using text as symbol • Repeated measures * • Layering options CD-ROM drive, • Over 16 million custom colors • Access new lines, fills, and symbols directly from graph prop- • Rates and proportions * 800x600 SVGA/256 color display or better or field-specific graphs. Use built-in macros as provided or use these sort through large amounts of data erties dialog, toolbar, legend page, and the symbol dialog box • Inset graphs inside one another • Correlation * • Selection of graph objects macros as a base to create your own macros. Share the power of to create and publish graphs that • Survival analysis (Kaplan-Meir, Cox Regression) * • Right-click property editing • Windows 2000, Windows XP, or Windows Vista; • Power and sample size analysis * • Color schemes Internet Explorer 6 or higher; SigmaPlot with less experienced users by tailoring the SigmaPlot can be transposed to manuscripts • Paste graphic objects from other programs Office 97 or higher (for Excel Integration, * New Features added in SigmaPlot 11 • Graph page rulers Paste to Powerpoint Slide, Insert Graphs into Word and other macros). interface to your application with macros. Create custom dialog boxes, and directly submitted to publications • Adjustable snap-to grids menu choices and forms to help guide novice users through a session. - the product is that user friendly and great! I can’t wait to upgrade to Tap into SigmaPlot’s capabilities from external sources that have Visual SigmaPlot 11. For more information, visit us at www.systat.com - Carmen Cuffari, Basic embedded, including Microsoft Word and Excel or custom software Exact Graphs and Data Analysis applications. Run a macro script in Microsoft Word or Excel that calls Pediatric Gastroenterologist, on SigmaPlot to access data, generate a graph and embed your report. Baltimore, MD North, Central & South Germany and Austria: UK and Ireland: India: Australia and New Zealand : America: Systat Software GmbH Systat Software, Inc. Cranes Software International Ltd. Cranes Software International Pty Ltd. With SigmaPlot’s OLE automation, you get unlimited flexibility. Systat Software, Inc. Schimmelbuschstr 25 UK Branch Office 4th Floor, Block 1, Level 6, College House 1735 Technology Drive, Suite 430 D-40699 Erkrath Germany 24, Vista Centre, 50 Salisbury Road, Shankar Narayan Bldg, 25, M.G. Road, 552 Lonsdale Street, Melbourne, 3000 San Jose, CA 95110 USA Phone: +49.2104.9540 Hounslow, - TW4 6JQ, London, UK. Bangalore, 560001, Karnataka, India Phone: 800-797-7401 Fax: +49.2104.95410 Australia +44-(0)208-538 0128 Fax: 800-797-7406 E-mail: [email protected] Phone: Phone: +91-80-41120000 Phone: +61 3 9670 8997 Email: [email protected] Fax: + 44-(0)208-538 0273 Fax: +91-80-4123 1274 Fax: +61 3 9602 5050 Email: [email protected] Email: [email protected] Email: [email protected] Distributors available in other countries www.systat.com Trial downloads available at www.systat.com © 2008 Systat Software, Inc. ® SigmaPlot 11 Features Error bars SMOOTHING "Picking from Column" Option • Mean, Median, First and Last values for symbols 2D & 3D Smoothing Routines • Enter colors, patterns, symbols, line styles, tick mark SigmaPlot 11 • Standard deviation, Standard error • Negative exponential intervals, tick labels and more directly into your worksheet GRAPHING FEATURES • 10th, 25th, 75th, and 90th Percentile • Running average to customize your graph the way you want. Transforms 2D • Min and Max • Loess and "picking from column" allow you to create data • Vector - 2 Types * • 95% or 99% confidence • Running median dependent color gradients, symbols and sizes. • Area Plots - 4 Types • Calculate error bars from replicate values across rows • Bisquare Automate Routine and Complex Tasks ® • Scatter - 14 types • User-defined upper and lower error bar values • Inverse square • Visual Basic compatible programming using built-in • Line - 4 types • One way, two way and asymmetric error bars • Inverse distance (for 3D smoothing) macro language interface • Scatter and Line - 10 types • Percentile method: 2-types • Macro recorder to save and play-back operations • Step - 8 types TRANSFORMATIONS Multiline Text Editor • Full automation object support - use Visual Basic to SigmaPlot 11 • Vertical Bar - 2 types, Vertical Grouped Bar - 2 types • Control font, size, style, color, Greek, multiple levels of Quick Transforms create your own SigmaPlot-based applications • Horizontal Bar - 2 types, Horizontal Grouped Bar - 2 types superscript & subscript, 360 degree rotation, left, right • Perform quick mathematical transforms provided in a • Run built-in macros or create and add your own scripts • Vertical, Stacked Bar & center justification, and line spacing function palette • Add menu commands and create dialog boxes The Standard for Data Analysis • Horizontal, Stacked Bar • Automatic Updating of multiple transforms in worksheets * • Toolbox menu: helpful macros appear as a separate • Box - 2 types Grids and Fills menu item • Polar - 3 types • Control of color, line type, thickness, and display of major & Mathematical Transforms • 36 probability density and cumulative transforms * • Export graph to PowerPoint Slide • Contour, line and filled - 2 types minor grids in X, Y, & Z direction • New 'Insert Graph to Microsoft Word' Toolbox macro • Histograms - 6 types • Control of pattern and edge color, pattern style, pattern • Histogram • Normalize ternary data • New keyboard shortcuts in the Graph Properties and most and Technical Graphing • Ternary - 3 types density, and edge thickness Symbols Microsoft Excel keyboard shortcuts in the worksheet • Bubble • Interpolate 3D mesh Reference Lines • Sorting Windows Application • Pie • Control mean, standard deviation, standard error, user-defined Analyze and Graph your Data • Fast Fourier transforms with filters • Excel, Word and PowerPoint for Office 2000 and • Control Charts constants, 95% and 99% confidence intervals • Needle • Lowess smoothing Windows 2000 support ToolTips • Up to 5 horizontal or vertical lines • Differential equations • Tips and Tricks at startup • High-low-close, Range, Quartile • Control of color, line type, and thickness • Quadrant • Data to RGB-color transform • Full 32-bit implementation with Unparalleled Ease and Precision • Population Drop lines • Trigonometric and algebraic functions • OLE 2 container and server • Display in any or all X, Y, and Z directions • Random and Gaussian random number generation • Use Excel worksheets inside SigmaPlot 3D • Range, accumulation, precision, and more • Controls have bitmaps to give feedback about selections Designed specifically to meet the needs of professional researchers • Select any object to make precise modifications * Legends • Transforms are now kept in notebook files as JNB files for • Right mouse button property editing • Automatically interpolate unordered 3D data • Automatic or manually created easier organization of transforms; create transform libraries; • Selection of objects on graph page • Multiple, intersecting plots with hidden line removal, • Legends for regressions, confidence, and prediction intervals associate Transforms with data sets • Full precision and date/time Microsoft Excel copy and paste smooth or discrete shading, transparent or opaque fills, • Turn on and off lines and symbols • Protect and track changes to transforms for 21 CFR Part 11 Many scientists have struggled to create the exact technical graph to best and light source shading • Place line and symbol before or after text Microsoft Office Integration • 3D rotation • You can open Excel spreadsheets directly inside Function Plotter GENERAL FEATURES SigmaPlot, allowing you to use the many features represent their research results using spreadsheet and data analysis programs. • Perspective preview • Plot 2D and 3D functions • Scatter Large, Scientific Worksheets Excel offers. Use in-cell formulas and other Excel data • Over 100 2D and 3D built-in, graphically-illustrated analysis tools on your data. Scientists like you designed the exact solution – SigmaPlot. It delivers a full • Bar equations • 32,000 columns by 32,000,000 rows • 3D line - trajectory • Handles numeric, text (categorical), and date & time data • One-click access to directly launch SigmaPlot from • User-defined parameters, scale and range Microsoft Excel range of graphing options and over 100 2-D and 3-D graph types. And flexible • Mesh - with or without contour projections • Customize the SigmaPlot library of functions or create your own • Data sorting • Contour • Plot functions on new or existing graphs • Rename, insert and delete rows and columns IMPORT & EXPORT OPTIONS • Waterfall • Plot multiple different parameter values simultaneously • Insert color, symbols, line styles and bar patterns Import editing options give you more control over the look and design of your graph Create Graphs Easily • Select line properties for each function • Independent graphically adjustable row height and • Directly import SAS data sets (.sd2 and .sas7bdat files) • Pre-formatted Worksheets: Use graph and worksheet dis • Equation Solver: solve equations or functions containing a column widths • Directly import Minitab data sets (.mtw & .mpj files) than you’ll find in other graphing packages plays to design the graph. Entering new data immediately single independent variable and any number of parameters • Missing data handling • Open Axon Binary, Axon Text, ASCII Plain, Comma and displays the results * • Data point sampling general import filter, 1-2-3T, Symphony T, Quattro T, Excel, Graphs Created Through Transforms • Program Startup Screen: helps both first time users or • Graphical feedback of current curve and datapoint dBASE E, DIF, all SigmaPlot files through SigmaPlot 9.01, • Gaussian cumulative distribution power users start their workflow with easy access to previously • Text support of up to 256 characters SigmaStat files (all versions), SYSTAT, SigmaScan Pro, • Area - shading under and between curves Analyze your data quickly and easily used documents, quick Excel and Access database import; • Change the font type and grid colors Sigma Scan, SigmaScan Image, Mocha • Z plane design use older documents as templates for new work • Change font for worksheet • Import any ODBC compliant database • Kaplan-Meier survival • Graph Style Gallery: Save any graph with all graph • Multiple Undo • Run SQL queries on tables and selectively import • Frequency SigmaPlot provides all the fundamental tools you need to analyze your data - properties and add a bitmap image to the gallery to recreate • Format empty cells - formatted selected columns even if they information • Complex Control charts do not contain data complex graphs Export Exact Graphs and Data Analysis from basic statistics to advanced mathematical calculations. Run one of the • Graph Toolbar: select toolbar icon of the graph type and style DATA ANALYSIS FEATURES • More flexible column titles allow for duplicates and • SAS files (.sd2 and .sas7bdat files) you want to create a graph or to add additional curves to an numeric only titles • Minitab files (.mtw & .mpj files) Regression Wizard existing graph • Enhanced data/time recognition and more formats • ASCII Text, Tabbed, Comma, 1-2-3T, Excel, DIF, all • Linear and nonlinear regressions many statistical tests with ease, fit a curve or plot a function and get a • Graph Wizard: easy to use, step-by-step wizard for helping • Arrow-key functionality is similar to that of Microsoft Excel SigmaPlot files though SigmaPlot 9.01, SigmaScan Pro • 2, 3, 4, and 5-segment piecewise-linear models you select a graph type and pick data • Freeze Panes and print preview • PDF, PSD and HTML export of graphs and reports • Over 100 built-in, graphically-illustrated equations detailed report of the results in seconds. Apply built-in transforms to • Default graph settings: set preferences for graph options to • Multi-line editing - text wraps to fit the column while the • Marquardt-Levenberg algorithm with up to 10 Import Graphics Options create favorite graphs more easily row height automatically adjusts independent variables and 25 parameters • Load popular graphic file formats directly into SigmaPlot • Templates: create custom graph page templates to store for • Find and replace data perform calculations in one easy step and create special graph types. Solve • Define constraints, tolerance, step size and iterations graphic page easy accessibility and future use • Automatically determines your initial parameters SigmaPlot Notebook Manager • Import BMP, JPEG, GIF, TIFF, Cursor and Icon Files & many more • "Intersections" now supported for area fills equations or functions containing a single independent variable and any • Writes a complete statistical report to your SigmaPlot Notebook • Dialog-bar-based notebook manager has several states: • Automatically graphs your results on new or existing graphs docks, resizable, hide-able, summary information mode, Graph Publication Export Options number of functions. With SigmaPlot it’s all so simple! Technical Axes • Option to add 95 or 99% confidence and prediction bands to a etc. • Submission Assistant stores an extensible list of • Reciprocal (including Arrhenius) results graph • Can hold SigmaPlot worksheets, Excel worksheets, publication requirements and is used to double check • Weibull • Optional Reduced Chi-Square Regression weighting reports, regression wizard equations, graph whether exported figures meet standards of publication • Linear • Customize the SigmaPlot fit library or create your own fit pages, transforms and macros. and allows creation of customized output profiles • Log10 functions • Direct-editing of notebook summary information • Export an individual graph, a group of graphs and objects, Share SigmaPlot graphs on the Internet • Natural log SigmaPlot Report Editor or an entire page • Probit Dynamic Fit Wizard • Cut and paste or use OLE to combine all the important aspects • Different levels of resolution and color depths: PDF, EPS, • Logit • Solves difficult curve fitting problems by finding local and global of your analysis into one document. Choose from a wide TIFF, JPEG, EMF, BMP The SigmaPlot WebViewer allows you to automatically generate active Web • Probability fit solutions range of styles, sizes, and colors from any system font. • True color EPS vector and CMYK EPS export • Reverse • Selects many initial maximally-distant starting parameter sets • Export to most word processors • Compressed CMYK TIFF pages from your graphs or embed the objects within other Web pages. • Ternary percentage and ranks the resulting fits • Add decimal tabs, tab leader, true date/time fields • Publication Help: guides user through the complexities • Ternary unary • Shows the local minima with a Dynamic Fit Profile graph • Auto-numbering selecting the correct DPI, image size, file export format Viewers can explore the data used in your graphs and zoom, pan or print • Polar (both clockwise and counter clockwise) • Improved formatting ruler Publish as Web Page • Category (text data automatically binned into groups) Global Fit Wizard * Page Layout and Annotation Options • Export graphs as high-resolution Web objects • Time and date • Fit multiple data sets using shared parameters * • Direct graphic file import into graph page • WebViewer: free browser plug-in to view data used to create images at full resolution directly from their Web browser. • User-defined custom axis to create almost any scale • Real-time mouse-over XY and page coordinate feedback graph or print, pan and zoom in on graph without Axis Features Automatic Linear Regressions • Click-through accessibility to select and edit graph losing resolution • Control of display, thickness, color, range, and axis breaks • Up to 10th order with confidence and prediction intervals objects buried under other items • The WebViewer supports IE 4.01 or higher. A screen resolution • Offset axes and regression statistics • OLE 2 container and server JPEG file is automatically displayed for browser applications • Automatic titles • Automatic or manual legends and operating systems Column Descriptive Statistics Generated Save time and effort by automating complex • Multiple axes: Add Axis Wizard for creating multiple axes easily • True WYSIWYG Automatically SYSTEM REQUIREMENTS • Ticks: customize major & minor intervals, in & out orientation, • Multiline text editor and repetitive tasks top & bottom location, length, thickness, color, and tick mark • Multiple curves and plots on one graph Hardware selection from column to create custom axes STATISTICS • Multiple axes on one graph • Windows Vista: • Labels: customize prefix, suffix, numeric, and time & date • Over 50 of the most frequently used statistical tests to analyze • Arrange graphs with built-in templates 1 GHz 32-bit (x86) or 64-bit (x64) processor, Create macros in no time with SigmaPlot’s easy-to-use VBA-based • Axis breaks: customize symbol, thickness, color, length, scientific research * • Multiple levels of zooming and custom zooming 1 GB of system memory, I’ve owned and used SigmaPlot gap width, and post break interval • Advisor Wizard guides you through the process of choosing • Easily change the size and position of multiple selected 100 MB of available hard disk space for more than a decade and I love it. Symbol Types the appropriate statistical test * objects simultaneously to lay out and arrange graphs CD-ROM drive, macro language. Not a programmer? No problem - record macros by • Over 80 symbol types • Report generation that translates the statistics into plain and and other objects quickly 800x600 SVGA/256 color display or better We do both clinical and • More line types for line plots and line scatter plots, simple English * • Scale graph to any size • Windows XP or below: • Descriptive statistics * • Resize graphic elements proportionally with resizing graph point and click with the macro recorder. Use macros to acquire your free-form lines, boxes and ellipses 300 megahertz (MHz) processor, • 50 fill patterns for bar charts, box plots, pie charts, • Non-parameter tests: t-tests, ANOVA * • Alignment and position tools pharmacological research and * 256 MB of system memory, data, execute powerful analytical methods and create industry-specific area plots and free-form boxes and ellipses • One-way, two-way, three-way ANOVA • Draw lines, ellipses, boxes, arrows 100 MB of available hard disk space SigmaPlot enables us to analyze and • Edit font when using text as symbol • Repeated measures * • Layering options CD-ROM drive, • Over 16 million custom colors • Access new lines, fills, and symbols directly from graph prop- • Rates and proportions * 800x600 SVGA/256 color display or better or field-specific graphs. Use built-in macros as provided or use these sort through large amounts of data erties dialog, toolbar, legend page, and the symbol dialog box • Inset graphs inside one another • Correlation * • Selection of graph objects Software macros as a base to create your own macros. Share the power of to create and publish graphs that • Survival analysis (Kaplan-Meir, Cox Regression) * • Right-click property editing • Windows 2000, Windows XP, or Windows Vista; • Power and sample size analysis * • Color schemes Internet Explorer 6 or higher; SigmaPlot with less experienced users by tailoring the SigmaPlot can be transposed to manuscripts • Paste graphic objects from other programs Office 97 or higher (for Excel Integration, * New Features added in SigmaPlot 11 • Graph page rulers Paste to Powerpoint Slide, Insert Graphs into Word and other macros). interface to your application with macros. Create custom dialog boxes, and directly submitted to publications • Adjustable snap-to grids menu choices and forms to help guide novice users through a session. - the product is that user friendly and great! I can’t wait to upgrade to Tap into SigmaPlot’s capabilities from external sources that have Visual SigmaPlot 11. For more information, visit us at www.systat.com - Carmen Cuffari, Basic embedded, including Microsoft Word and Excel or custom software Exact Graphs and Data Analysis applications. Run a macro script in Microsoft Word or Excel that calls Pediatric Gastroenterologist, on SigmaPlot to access data, generate a graph and embed your report. Baltimore, MD North, Central & South Germany and Austria: UK and Ireland: India: Australia and New Zealand : America: Systat Software GmbH Systat Software, Inc. Cranes Software International Ltd. Cranes Software International Pty Ltd. With SigmaPlot’s OLE automation, you get unlimited flexibility. Systat Software, Inc. Schimmelbuschstr 25 UK Branch Office 4th Floor, Block 1, Level 6, College House 1735 Technology Drive, Suite 430 D-40699 Erkrath Germany 24, Vista Centre, 50 Salisbury Road, Shankar Narayan Bldg, 25, M.G. Road, 552 Lonsdale Street, Melbourne, 3000 San Jose, CA 95110 USA Phone: +49.2104.9540 Hounslow, - TW4 6JQ, London, UK. Bangalore, 560001, Karnataka, India Phone: 800-797-7401 Fax: +49.2104.95410 Australia +44-(0)208-538 0128 Fax: 800-797-7406 E-mail: [email protected] Phone: Phone: +91-80-41120000 Phone: +61 3 9670 8997 Email: [email protected] Fax: + 44-(0)208-538 0273 Fax: +91-80-4123 1274 Fax: +61 3 9602 5050 Email: [email protected] Email: [email protected] Email: [email protected] Distributors available in other countries www.systat.com Trial downloads available at www.systat.com © 2008 Systat Software, Inc. SigmaPlot® 11 SigmaPlot® 11 SigmaPlot ® 11

The Premier Data Analysis and The Simplest and most Effective way Use SigmaPlot to Gain more Insight Scientific Graphing Package to Analyze and Graph your Data into your Data and Research

SigmaPlot® is a scientific data analysis and graphing software package with an intuitive interface and Choose from a wide range of graph types to best Create standard or asymmetric error bars. Insert Placing SigmaPlot graphs into Microsoft You can even add your own equations to the wizard technology that is designed to guide users through their analysis and graphing needs. SigmaPlot’s present your results axis breaks and add technical detail with the PowerPoint slides and Microsoft Word Regression Wizard. For more complicated models graphing capabilities provide the flexibility to easily customize every graph detail and create publication- SigmaPlot provides more than 100 different 2-D and scientific text editor. Paste equations, symbols, documents is a breeze! with problematic data, SigmaPlot’s new Dynamic quality graphs. SigmaPlot’s analytical features include advanced curve fitting capabilities and 3-D graph types. From simple 2-D scatter plots to maps and other images into your presentation. Fit Wizard searches even harder to find the best step-by-step guidance in performing over 50 frequently used statistical tests. compelling contour plots, SigmaPlot gives you the exact SigmaPlot’s solution to your difficult curve fitting problems. technical graph type you need for your demanding toolbar palettes The Dynamic Fit Wizard is a powerful analytical ROC Curve Analysis Find the exact graph for your SigmaPlot now offers Complete research. With so many options, you can always find the make editing tool giving you the ability to automatically try as Module demanding research in the Advisory Statistics Methods your graphs many initial starting conditions as necessary to Graph Toolbar Manage and analyze your data efficiently best visual representation of your data. Determine which clinical test SigmaPlot provides more than 50 and accurately faster than ever is best by creating ROC curves SigmaPlot provides more than 100 different statistical analysis method assure the best fit is found. Analyze multiple data and comparing their areas using different 2D and 3D graph types so types.Users will always achieve Manipulate millions of data points in SigmaPlot’s Instantly access SigmaPlot from Excel and toolbars are sets simultaneously with paired and unpaired data. Even you can always find the best visual meaningful statistical results without powerful scientific data worksheet. SigmaPlot handles missing values representation of your data. having to be a statistician provides all the tools needed to analyze data, Combine two now fully parameters from basic statistics to advanced mathematical customizable. shared across calculations powerful software packages. Launch Set properties data families SigmaPlot’s Graph like line thickness, using Global Create a Wizard directly tick lengths and Now you can incorporate clear and exact graphs in Curve Fitting. preformatted fonts, then apply your changes to multiple worksheet from Microsoft® your reports and presentations. Just select the “Paste Over 130 Select the type of Excel® to create selections. Save properties of your favorite graphs to PowerPoint” or “Insert into MS Word” commands built-in graph desired with your exact technical in the Graph Style Gallery to quickly recreate the from the Toolbox drop-down menu and your graphs equations can be fit to your data. possible detailed error bars and a graph. SigmaPlot’s same graphs using new data. are automatically placed in the file worksheet with the Manage your work efficiently direct access from Excel eliminates tedious cut-and Clearly present your exact scientific ideas correct data format Get Enhanced Statistical Power Graph Style Gallery will be created. Data paste data preparation steps. Manipulate Save time by quickly plotting your entered into the Compare and contrast trends in your data by data using previously saved work-sheet is Use Pre formatted Worksheets to easily creating multiple axes per graph, multiple graphs SigmaPlot now offers almost 50 of the most millions of data styles or templates. immediately graphed create your graphs per page and multiple pages per worksheet. Arrange frequently used statistical tests in scientific research. points in Suggestion of the most appropriate SigmaPlot’s Select the type multiple graphs accurately in no time using your statistical test is offered. Raw and indexed powerful of graph desired own page layouts with SigmaPlot’s WYSIWYG data formats are accepted to avoid data scientific Global Curve Fit with possible layout and zoom features. reformatting. Violation of data data worksheet. Analyze multiple data detailed error Publish your SigmaPlot graphs anywhere sets simultaneously assumptions is checked in the With new Audit with parameters bars and a Create stunning presentations, high-quality graphics background. Reports with descriptive Trails, laboratories Quickly and easily customize every Interactive Graph shared across data families. Shared parameter variability is worksheet with detail of your graphs Wizard for journals or detailed charts for your reports with interpretations are generated and graphs Organise graph pages, SigmaPlot or can easily track Ligand Binding Module typically reduced in this way. the correct data Excel data worksheets, curve fit results, Double-click and edit any element to your exact SigmaPlot leads the user SigmaPlot’s wide range of export options. Export specific to each test may be created. transforms and reportseffectively in the changes to note- requirements. Create professional quality Automatically fit radioligand and step-by-step through format will be your graphs as PDF, True CMYK EPS, TIF CMYK, SigmaPlot Notebook manager books, simplifying graphs for presentations, publications or the dose response studies for multiple graph creation created. Data web with a wide range of export options like compounds with replicate data. JPEG, GIF, HTML, EMF, PSD and even vector EPS- 21 CFR Part 11 compliance by logging changes. TIFF, CMYK, PDF, HTML and more. entered in the Fit your data easily and accurately CMYK - the preferred format for publication. The Run simple mathematical transforms effortlessly worksheet is immediately graphed. Get More from SigmaPlot with Add-On Modules Submission Assistant stores an extensible list of The Regression Wizard automatically determines your using SigmaPlot’s Quick Transforms feature or publication requirements that is used to double initial parameters, writes a statistical report, saves your create powerful mathematical routines to Enzyme Kinetics Module ROC Curve Analysis Module Electrophysiology Module Ligand Binding Module Customize every element of your graphs check whether exported figures meet the perform complex analysis with SigmaPlot’s The automatic choice for analyzing (Part of SigmaPlot) Directly read your electrophysiology (Part of SigmaPlot) equation to the SigmaPlot Notebook, and adds your SigmaPlot gives you the flexibility to customize every publication standards. The new enhanced metafile transform language. Elect to have Quick enzyme kinetics data. Determine which clinical test data into SigmaPlot. Automatically fit radioligand and results to existing graphs or creates a new one! The is best by creating ROC Curves This module guides you through This module saves you the time dose response studies for multiple detail of your graph. Double-click on any element to format (EMF) extends the 16 bit windows metafile Regression Wizard fits nearly any equation – piecewise Transforms automatically recalculated on your and comparing their areas using data entry, analysis and graphing and effort of manually entering compounds with replicate data paired and unpaired data. Even launch the Graph Properties box and begin editing. format (WMF) to 32 bits which provides enhanced continuous, multifunctional, weighted, Boolean functions worksheet. Save time by writing a transform of your enzyme kinetics data. data into SigmaPlot handles missing values. Choose from very clearly illustrated options. Specify graph representation in the graph gallery and and more – up to 10 variables and 25 parameters. once and saving it for future use. Access built-in different colors, sizes and symbols for each data point. extended paste and paste special features. transforms or create your own.

Trial downloads available at www.systat.com Trial downloads available at www.systat.com Trial downloads available at www.systat.com SigmaPlot® 11 SigmaPlot® 11 SigmaPlot ® 11

The Premier Data Analysis and The Simplest and most Effective way Use SigmaPlot to Gain more Insight Scientific Graphing Package to Analyze and Graph your Data into your Data and Research

SigmaPlot® is a scientific data analysis and graphing software package with an intuitive interface and Choose from a wide range of graph types to best Create standard or asymmetric error bars. Insert Placing SigmaPlot graphs into Microsoft You can even add your own equations to the wizard technology that is designed to guide users through their analysis and graphing needs. SigmaPlot’s present your results axis breaks and add technical detail with the PowerPoint slides and Microsoft Word Regression Wizard. For more complicated models graphing capabilities provide the flexibility to easily customize every graph detail and create publication- SigmaPlot provides more than 100 different 2-D and scientific text editor. Paste equations, symbols, documents is a breeze! with problematic data, SigmaPlot’s new Dynamic quality graphs. SigmaPlot’s analytical features include advanced curve fitting capabilities and 3-D graph types. From simple 2-D scatter plots to maps and other images into your presentation. Fit Wizard searches even harder to find the best step-by-step guidance in performing over 50 frequently used statistical tests. compelling contour plots, SigmaPlot gives you the exact SigmaPlot’s solution to your difficult curve fitting problems. technical graph type you need for your demanding toolbar palettes The Dynamic Fit Wizard is a powerful analytical ROC Curve Analysis Find the exact graph for your SigmaPlot now offers Complete research. With so many options, you can always find the make editing tool giving you the ability to automatically try as Module demanding research in the Advisory Statistics Methods your graphs many initial starting conditions as necessary to Graph Toolbar Manage and analyze your data efficiently best visual representation of your data. Determine which clinical test SigmaPlot provides more than 50 and accurately faster than ever is best by creating ROC curves SigmaPlot provides more than 100 different statistical analysis method assure the best fit is found. Analyze multiple data and comparing their areas using different 2D and 3D graph types so types.Users will always achieve Manipulate millions of data points in SigmaPlot’s Instantly access SigmaPlot from Excel and toolbars are sets simultaneously with paired and unpaired data. Even you can always find the best visual meaningful statistical results without powerful scientific data worksheet. SigmaPlot handles missing values representation of your data. having to be a statistician provides all the tools needed to analyze data, Combine two now fully parameters from basic statistics to advanced mathematical customizable. shared across calculations powerful software packages. Launch Set properties data families SigmaPlot’s Graph like line thickness, using Global Create a Wizard directly tick lengths and Now you can incorporate clear and exact graphs in Curve Fitting. preformatted fonts, then apply your changes to multiple worksheet from Microsoft® your reports and presentations. Just select the “Paste Over 130 Select the type of Excel® to create selections. Save properties of your favorite graphs to PowerPoint” or “Insert into MS Word” commands built-in graph desired with your exact technical in the Graph Style Gallery to quickly recreate the from the Toolbox drop-down menu and your graphs equations can be fit to your data. possible detailed error bars and a graph. SigmaPlot’s same graphs using new data. are automatically placed in the file worksheet with the Manage your work efficiently direct access from Excel eliminates tedious cut-and Clearly present your exact scientific ideas correct data format Get Enhanced Statistical Power Graph Style Gallery will be created. Data paste data preparation steps. Manipulate Save time by quickly plotting your entered into the Compare and contrast trends in your data by data using previously saved work-sheet is Use Pre formatted Worksheets to easily creating multiple axes per graph, multiple graphs SigmaPlot now offers almost 50 of the most millions of data styles or templates. immediately graphed create your graphs per page and multiple pages per worksheet. Arrange frequently used statistical tests in scientific research. points in Suggestion of the most appropriate SigmaPlot’s Select the type multiple graphs accurately in no time using your statistical test is offered. Raw and indexed powerful of graph desired own page layouts with SigmaPlot’s WYSIWYG data formats are accepted to avoid data scientific Global Curve Fit with possible layout and zoom features. reformatting. Violation of data data worksheet. Analyze multiple data detailed error Publish your SigmaPlot graphs anywhere sets simultaneously assumptions is checked in the With new Audit with parameters bars and a Create stunning presentations, high-quality graphics background. Reports with descriptive Trails, laboratories Quickly and easily customize every Interactive Graph shared across data families. Shared parameter variability is worksheet with detail of your graphs Wizard for journals or detailed charts for your reports with interpretations are generated and graphs Organise graph pages, SigmaPlot or can easily track Ligand Binding Module typically reduced in this way. the correct data Excel data worksheets, curve fit results, Double-click and edit any element to your exact SigmaPlot leads the user SigmaPlot’s wide range of export options. Export specific to each test may be created. transforms and reportseffectively in the changes to note- requirements. Create professional quality Automatically fit radioligand and step-by-step through format will be your graphs as PDF, True CMYK EPS, TIF CMYK, SigmaPlot Notebook manager books, simplifying graphs for presentations, publications or the dose response studies for multiple graph creation created. Data web with a wide range of export options like compounds with replicate data. JPEG, GIF, HTML, EMF, PSD and even vector EPS- 21 CFR Part 11 compliance by logging changes. TIFF, CMYK, PDF, HTML and more. entered in the Fit your data easily and accurately CMYK - the preferred format for publication. The Run simple mathematical transforms effortlessly worksheet is immediately graphed. Get More from SigmaPlot with Add-On Modules Submission Assistant stores an extensible list of The Regression Wizard automatically determines your using SigmaPlot’s Quick Transforms feature or publication requirements that is used to double initial parameters, writes a statistical report, saves your create powerful mathematical routines to Enzyme Kinetics Module ROC Curve Analysis Module Electrophysiology Module Ligand Binding Module Customize every element of your graphs check whether exported figures meet the perform complex analysis with SigmaPlot’s The automatic choice for analyzing (Part of SigmaPlot) Directly read your electrophysiology (Part of SigmaPlot) equation to the SigmaPlot Notebook, and adds your SigmaPlot gives you the flexibility to customize every publication standards. The new enhanced metafile transform language. Elect to have Quick enzyme kinetics data. Determine which clinical test data into SigmaPlot. Automatically fit radioligand and results to existing graphs or creates a new one! The is best by creating ROC Curves This module guides you through This module saves you the time dose response studies for multiple detail of your graph. Double-click on any element to format (EMF) extends the 16 bit windows metafile Regression Wizard fits nearly any equation – piecewise Transforms automatically recalculated on your and comparing their areas using data entry, analysis and graphing and effort of manually entering compounds with replicate data paired and unpaired data. Even launch the Graph Properties box and begin editing. format (WMF) to 32 bits which provides enhanced continuous, multifunctional, weighted, Boolean functions worksheet. Save time by writing a transform of your enzyme kinetics data. data into SigmaPlot handles missing values. Choose from very clearly illustrated options. Specify graph representation in the graph gallery and and more – up to 10 variables and 25 parameters. once and saving it for future use. Access built-in different colors, sizes and symbols for each data point. extended paste and paste special features. transforms or create your own.

Trial downloads available at www.systat.com Trial downloads available at www.systat.com Trial downloads available at www.systat.com SigmaPlot® 11 SigmaPlot® 11 SigmaPlot ® 11

The Premier Data Analysis and The Simplest and most Effective way Use SigmaPlot to Gain more Insight Scientific Graphing Package to Analyze and Graph your Data into your Data and Research

SigmaPlot® is a scientific data analysis and graphing software package with an intuitive interface and Choose from a wide range of graph types to best Create standard or asymmetric error bars. Insert Placing SigmaPlot graphs into Microsoft You can even add your own equations to the wizard technology that is designed to guide users through their analysis and graphing needs. SigmaPlot’s present your results axis breaks and add technical detail with the PowerPoint slides and Microsoft Word Regression Wizard. For more complicated models graphing capabilities provide the flexibility to easily customize every graph detail and create publication- SigmaPlot provides more than 100 different 2-D and scientific text editor. Paste equations, symbols, documents is a breeze! with problematic data, SigmaPlot’s new Dynamic quality graphs. SigmaPlot’s analytical features include advanced curve fitting capabilities and 3-D graph types. From simple 2-D scatter plots to maps and other images into your presentation. Fit Wizard searches even harder to find the best step-by-step guidance in performing over 50 frequently used statistical tests. compelling contour plots, SigmaPlot gives you the exact SigmaPlot’s solution to your difficult curve fitting problems. technical graph type you need for your demanding toolbar palettes The Dynamic Fit Wizard is a powerful analytical ROC Curve Analysis Find the exact graph for your SigmaPlot now offers Complete research. With so many options, you can always find the make editing tool giving you the ability to automatically try as Module demanding research in the Advisory Statistics Methods your graphs many initial starting conditions as necessary to Graph Toolbar Manage and analyze your data efficiently best visual representation of your data. Determine which clinical test SigmaPlot provides more than 50 and accurately faster than ever is best by creating ROC curves SigmaPlot provides more than 100 different statistical analysis method assure the best fit is found. Analyze multiple data and comparing their areas using different 2D and 3D graph types so types.Users will always achieve Manipulate millions of data points in SigmaPlot’s Instantly access SigmaPlot from Excel and toolbars are sets simultaneously with paired and unpaired data. Even you can always find the best visual meaningful statistical results without powerful scientific data worksheet. SigmaPlot handles missing values representation of your data. having to be a statistician provides all the tools needed to analyze data, Combine two now fully parameters from basic statistics to advanced mathematical customizable. shared across calculations powerful software packages. Launch Set properties data families SigmaPlot’s Graph like line thickness, using Global Create a Wizard directly tick lengths and Now you can incorporate clear and exact graphs in Curve Fitting. preformatted fonts, then apply your changes to multiple worksheet from Microsoft® your reports and presentations. Just select the “Paste Over 130 Select the type of Excel® to create selections. Save properties of your favorite graphs to PowerPoint” or “Insert into MS Word” commands built-in graph desired with your exact technical in the Graph Style Gallery to quickly recreate the from the Toolbox drop-down menu and your graphs equations can be fit to your data. possible detailed error bars and a graph. SigmaPlot’s same graphs using new data. are automatically placed in the file worksheet with the Manage your work efficiently direct access from Excel eliminates tedious cut-and Clearly present your exact scientific ideas correct data format Get Enhanced Statistical Power Graph Style Gallery will be created. Data paste data preparation steps. Manipulate Save time by quickly plotting your entered into the Compare and contrast trends in your data by data using previously saved work-sheet is Use Pre formatted Worksheets to easily creating multiple axes per graph, multiple graphs SigmaPlot now offers almost 50 of the most millions of data styles or templates. immediately graphed create your graphs per page and multiple pages per worksheet. Arrange frequently used statistical tests in scientific research. points in Suggestion of the most appropriate SigmaPlot’s Select the type multiple graphs accurately in no time using your statistical test is offered. Raw and indexed powerful of graph desired own page layouts with SigmaPlot’s WYSIWYG data formats are accepted to avoid data scientific Global Curve Fit with possible layout and zoom features. reformatting. Violation of data data worksheet. Analyze multiple data detailed error Publish your SigmaPlot graphs anywhere sets simultaneously assumptions is checked in the With new Audit with parameters bars and a Create stunning presentations, high-quality graphics background. Reports with descriptive Trails, laboratories Quickly and easily customize every Interactive Graph shared across data families. Shared parameter variability is worksheet with detail of your graphs Wizard for journals or detailed charts for your reports with interpretations are generated and graphs Organise graph pages, SigmaPlot or can easily track Ligand Binding Module typically reduced in this way. the correct data Excel data worksheets, curve fit results, Double-click and edit any element to your exact SigmaPlot leads the user SigmaPlot’s wide range of export options. Export specific to each test may be created. transforms and reportseffectively in the changes to note- requirements. Create professional quality Automatically fit radioligand and step-by-step through format will be your graphs as PDF, True CMYK EPS, TIF CMYK, SigmaPlot Notebook manager books, simplifying graphs for presentations, publications or the dose response studies for multiple graph creation created. Data web with a wide range of export options like compounds with replicate data. JPEG, GIF, HTML, EMF, PSD and even vector EPS- 21 CFR Part 11 compliance by logging changes. TIFF, CMYK, PDF, HTML and more. entered in the Fit your data easily and accurately CMYK - the preferred format for publication. The Run simple mathematical transforms effortlessly worksheet is immediately graphed. Get More from SigmaPlot with Add-On Modules Submission Assistant stores an extensible list of The Regression Wizard automatically determines your using SigmaPlot’s Quick Transforms feature or publication requirements that is used to double initial parameters, writes a statistical report, saves your create powerful mathematical routines to Enzyme Kinetics Module ROC Curve Analysis Module Electrophysiology Module Ligand Binding Module Customize every element of your graphs check whether exported figures meet the perform complex analysis with SigmaPlot’s The automatic choice for analyzing (Part of SigmaPlot) Directly read your electrophysiology (Part of SigmaPlot) equation to the SigmaPlot Notebook, and adds your SigmaPlot gives you the flexibility to customize every publication standards. The new enhanced metafile transform language. Elect to have Quick enzyme kinetics data. Determine which clinical test data into SigmaPlot. Automatically fit radioligand and results to existing graphs or creates a new one! The is best by creating ROC Curves This module guides you through This module saves you the time dose response studies for multiple detail of your graph. Double-click on any element to format (EMF) extends the 16 bit windows metafile Regression Wizard fits nearly any equation – piecewise Transforms automatically recalculated on your and comparing their areas using data entry, analysis and graphing and effort of manually entering compounds with replicate data paired and unpaired data. Even launch the Graph Properties box and begin editing. format (WMF) to 32 bits which provides enhanced continuous, multifunctional, weighted, Boolean functions worksheet. Save time by writing a transform of your enzyme kinetics data. data into SigmaPlot handles missing values. Choose from very clearly illustrated options. Specify graph representation in the graph gallery and and more – up to 10 variables and 25 parameters. once and saving it for future use. Access built-in different colors, sizes and symbols for each data point. extended paste and paste special features. transforms or create your own.

Trial downloads available at www.systat.com Trial downloads available at www.systat.com Trial downloads available at www.systat.com ® SigmaPlot 11 Features Error bars SMOOTHING "Picking from Column" Option • Mean, Median, First and Last values for symbols 2D & 3D Smoothing Routines • Enter colors, patterns, symbols, line styles, tick mark SigmaPlot 11 • Standard deviation, Standard error • Negative exponential intervals, tick labels and more directly into your worksheet GRAPHING FEATURES • 10th, 25th, 75th, and 90th Percentile • Running average to customize your graph the way you want. Transforms 2D • Min and Max • Loess and "picking from column" allow you to create data • Vector - 2 Types * • 95% or 99% confidence • Running median dependent color gradients, symbols and sizes. • Area Plots - 4 Types • Calculate error bars from replicate values across rows • Bisquare Automate Routine and Complex Tasks ® • Scatter - 14 types • User-defined upper and lower error bar values • Inverse square • Visual Basic compatible programming using built-in • Line - 4 types • One way, two way and asymmetric error bars • Inverse distance (for 3D smoothing) macro language interface • Scatter and Line - 10 types • Percentile method: 2-types • Macro recorder to save and play-back operations • Step - 8 types TRANSFORMATIONS Multiline Text Editor • Full automation object support - use Visual Basic to SigmaPlot 11 • Vertical Bar - 2 types, Vertical Grouped Bar - 2 types • Control font, size, style, color, Greek, multiple levels of Quick Transforms create your own SigmaPlot-based applications • Horizontal Bar - 2 types, Horizontal Grouped Bar - 2 types superscript & subscript, 360 degree rotation, left, right • Perform quick mathematical transforms provided in a • Run built-in macros or create and add your own scripts • Vertical, Stacked Bar & center justification, and line spacing function palette • Add menu commands and create dialog boxes The Standard for Data Analysis • Horizontal, Stacked Bar • Automatic Updating of multiple transforms in worksheets * • Toolbox menu: helpful macros appear as a separate • Box - 2 types Grids and Fills menu item • Polar - 3 types • Control of color, line type, thickness, and display of major & Mathematical Transforms • 36 probability density and cumulative transforms * • Export graph to PowerPoint Slide • Contour, line and filled - 2 types minor grids in X, Y, & Z direction • New 'Insert Graph to Microsoft Word' Toolbox macro • Histograms - 6 types • Control of pattern and edge color, pattern style, pattern • Histogram • Normalize ternary data • New keyboard shortcuts in the Graph Properties and most and Technical Graphing • Ternary - 3 types density, and edge thickness Symbols Microsoft Excel keyboard shortcuts in the worksheet • Bubble • Interpolate 3D mesh Reference Lines • Sorting Windows Application • Pie • Control mean, standard deviation, standard error, user-defined Analyze and Graph your Data • Fast Fourier transforms with filters • Excel, Word and PowerPoint for Office 2000 and • Control Charts constants, 95% and 99% confidence intervals • Needle • Lowess smoothing Windows 2000 support ToolTips • Up to 5 horizontal or vertical lines • Differential equations • Tips and Tricks at startup • High-low-close, Range, Quartile • Control of color, line type, and thickness • Quadrant • Data to RGB-color transform • Full 32-bit implementation with Unparalleled Ease and Precision • Population Drop lines • Trigonometric and algebraic functions • OLE 2 container and server • Display in any or all X, Y, and Z directions • Random and Gaussian random number generation • Use Excel worksheets inside SigmaPlot 3D • Range, accumulation, precision, and more • Controls have bitmaps to give feedback about selections Designed specifically to meet the needs of professional researchers • Select any object to make precise modifications * Legends • Transforms are now kept in notebook files as JNB files for • Right mouse button property editing • Automatically interpolate unordered 3D data • Automatic or manually created easier organization of transforms; create transform libraries; • Selection of objects on graph page • Multiple, intersecting plots with hidden line removal, • Legends for regressions, confidence, and prediction intervals associate Transforms with data sets • Full precision and date/time Microsoft Excel copy and paste smooth or discrete shading, transparent or opaque fills, • Turn on and off lines and symbols • Protect and track changes to transforms for 21 CFR Part 11 Many scientists have struggled to create the exact technical graph to best and light source shading • Place line and symbol before or after text Microsoft Office Integration • 3D rotation • You can open Excel spreadsheets directly inside Function Plotter GENERAL FEATURES SigmaPlot, allowing you to use the many features represent their research results using spreadsheet and data analysis programs. • Perspective preview • Plot 2D and 3D functions • Scatter Large, Scientific Worksheets Excel offers. Use in-cell formulas and other Excel data • Over 100 2D and 3D built-in, graphically-illustrated analysis tools on your data. Scientists like you designed the exact solution – SigmaPlot. It delivers a full • Bar equations • 32,000 columns by 32,000,000 rows • 3D line - trajectory • Handles numeric, text (categorical), and date & time data • One-click access to directly launch SigmaPlot from • User-defined parameters, scale and range Microsoft Excel range of graphing options and over 100 2-D and 3-D graph types. And flexible • Mesh - with or without contour projections • Customize the SigmaPlot library of functions or create your own • Data sorting • Contour • Plot functions on new or existing graphs • Rename, insert and delete rows and columns IMPORT & EXPORT OPTIONS • Waterfall • Plot multiple different parameter values simultaneously • Insert color, symbols, line styles and bar patterns Import editing options give you more control over the look and design of your graph Create Graphs Easily • Select line properties for each function • Independent graphically adjustable row height and • Directly import SAS data sets (.sd2 and .sas7bdat files) • Pre-formatted Worksheets: Use graph and worksheet dis • Equation Solver: solve equations or functions containing a column widths • Directly import Minitab data sets (.mtw & .mpj files) than you’ll find in other graphing packages plays to design the graph. Entering new data immediately single independent variable and any number of parameters • Missing data handling • Open Axon Binary, Axon Text, ASCII Plain, Comma and displays the results * • Data point sampling general import filter, 1-2-3T, Symphony T, Quattro T, Excel, Graphs Created Through Transforms • Program Startup Screen: helps both first time users or • Graphical feedback of current curve and datapoint dBASE E, DIF, all SigmaPlot files through SigmaPlot 9.01, • Gaussian cumulative distribution power users start their workflow with easy access to previously • Text support of up to 256 characters SigmaStat files (all versions), SYSTAT, SigmaScan Pro, • Area - shading under and between curves Analyze your data quickly and easily used documents, quick Excel and Access database import; • Change the font type and grid colors Sigma Scan, SigmaScan Image, Mocha • Z plane design use older documents as templates for new work • Change font for worksheet • Import any ODBC compliant database • Kaplan-Meier survival • Graph Style Gallery: Save any graph with all graph • Multiple Undo • Run SQL queries on tables and selectively import • Frequency SigmaPlot provides all the fundamental tools you need to analyze your data - properties and add a bitmap image to the gallery to recreate • Format empty cells - formatted selected columns even if they information • Complex Control charts do not contain data complex graphs Export Exact Graphs and Data Analysis from basic statistics to advanced mathematical calculations. Run one of the • Graph Toolbar: select toolbar icon of the graph type and style DATA ANALYSIS FEATURES • More flexible column titles allow for duplicates and • SAS files (.sd2 and .sas7bdat files) you want to create a graph or to add additional curves to an numeric only titles • Minitab files (.mtw & .mpj files) Regression Wizard existing graph • Enhanced data/time recognition and more formats • ASCII Text, Tabbed, Comma, 1-2-3T, Excel, DIF, all • Linear and nonlinear regressions many statistical tests with ease, fit a curve or plot a function and get a • Graph Wizard: easy to use, step-by-step wizard for helping • Arrow-key functionality is similar to that of Microsoft Excel SigmaPlot files though SigmaPlot 9.01, SigmaScan Pro • 2, 3, 4, and 5-segment piecewise-linear models you select a graph type and pick data • Freeze Panes and print preview • PDF, PSD and HTML export of graphs and reports • Over 100 built-in, graphically-illustrated equations detailed report of the results in seconds. Apply built-in transforms to • Default graph settings: set preferences for graph options to • Multi-line editing - text wraps to fit the column while the • Marquardt-Levenberg algorithm with up to 10 Import Graphics Options create favorite graphs more easily row height automatically adjusts independent variables and 25 parameters • Load popular graphic file formats directly into SigmaPlot • Templates: create custom graph page templates to store for • Find and replace data perform calculations in one easy step and create special graph types. Solve • Define constraints, tolerance, step size and iterations graphic page easy accessibility and future use • Automatically determines your initial parameters SigmaPlot Notebook Manager • Import BMP, JPEG, GIF, TIFF, Cursor and Icon Files & many more • "Intersections" now supported for area fills equations or functions containing a single independent variable and any • Writes a complete statistical report to your SigmaPlot Notebook • Dialog-bar-based notebook manager has several states: • Automatically graphs your results on new or existing graphs docks, resizable, hide-able, summary information mode, Graph Publication Export Options number of functions. With SigmaPlot it’s all so simple! Technical Axes • Option to add 95 or 99% confidence and prediction bands to a etc. • Submission Assistant stores an extensible list of • Reciprocal (including Arrhenius) results graph • Can hold SigmaPlot worksheets, Excel worksheets, publication requirements and is used to double check • Weibull • Optional Reduced Chi-Square Regression weighting reports, regression wizard equations, graph whether exported figures meet standards of publication • Linear • Customize the SigmaPlot fit library or create your own fit pages, transforms and macros. and allows creation of customized output profiles • Log10 functions • Direct-editing of notebook summary information • Export an individual graph, a group of graphs and objects, Share SigmaPlot graphs on the Internet • Natural log SigmaPlot Report Editor or an entire page • Probit Dynamic Fit Wizard • Cut and paste or use OLE to combine all the important aspects • Different levels of resolution and color depths: PDF, EPS, • Logit • Solves difficult curve fitting problems by finding local and global of your analysis into one document. Choose from a wide TIFF, JPEG, EMF, BMP The SigmaPlot WebViewer allows you to automatically generate active Web • Probability fit solutions range of styles, sizes, and colors from any system font. • True color EPS vector and CMYK EPS export • Reverse • Selects many initial maximally-distant starting parameter sets • Export to most word processors • Compressed CMYK TIFF pages from your graphs or embed the objects within other Web pages. • Ternary percentage and ranks the resulting fits • Add decimal tabs, tab leader, true date/time fields • Publication Help: guides user through the complexities • Ternary unary • Shows the local minima with a Dynamic Fit Profile graph • Auto-numbering selecting the correct DPI, image size, file export format Viewers can explore the data used in your graphs and zoom, pan or print • Polar (both clockwise and counter clockwise) • Improved formatting ruler Publish as Web Page • Category (text data automatically binned into groups) Global Fit Wizard * Page Layout and Annotation Options • Export graphs as high-resolution Web objects • Time and date • Fit multiple data sets using shared parameters * • Direct graphic file import into graph page • WebViewer: free browser plug-in to view data used to create images at full resolution directly from their Web browser. • User-defined custom axis to create almost any scale • Real-time mouse-over XY and page coordinate feedback graph or print, pan and zoom in on graph without Axis Features Automatic Linear Regressions • Click-through accessibility to select and edit graph losing resolution • Control of display, thickness, color, range, and axis breaks • Up to 10th order with confidence and prediction intervals objects buried under other items • The WebViewer supports IE 4.01 or higher. A screen resolution • Offset axes and regression statistics • OLE 2 container and server JPEG file is automatically displayed for browser applications • Automatic titles • Automatic or manual legends and operating systems Column Descriptive Statistics Generated Save time and effort by automating complex • Multiple axes: Add Axis Wizard for creating multiple axes easily • True WYSIWYG Automatically SYSTEM REQUIREMENTS • Ticks: customize major & minor intervals, in & out orientation, • Multiline text editor and repetitive tasks top & bottom location, length, thickness, color, and tick mark • Multiple curves and plots on one graph Hardware selection from column to create custom axes STATISTICS • Multiple axes on one graph • Windows Vista: • Labels: customize prefix, suffix, numeric, and time & date • Over 50 of the most frequently used statistical tests to analyze • Arrange graphs with built-in templates 1 GHz 32-bit (x86) or 64-bit (x64) processor, Create macros in no time with SigmaPlot’s easy-to-use VBA-based • Axis breaks: customize symbol, thickness, color, length, scientific research * • Multiple levels of zooming and custom zooming 1 GB of system memory, I’ve owned and used SigmaPlot gap width, and post break interval • Advisor Wizard guides you through the process of choosing • Easily change the size and position of multiple selected 100 MB of available hard disk space for more than a decade and I love it. Symbol Types the appropriate statistical test * objects simultaneously to lay out and arrange graphs CD-ROM drive, macro language. Not a programmer? No problem - record macros by • Over 80 symbol types • Report generation that translates the statistics into plain and and other objects quickly 800x600 SVGA/256 color display or better We do both clinical and • More line types for line plots and line scatter plots, simple English * • Scale graph to any size • Windows XP or below: • Descriptive statistics * • Resize graphic elements proportionally with resizing graph point and click with the macro recorder. Use macros to acquire your free-form lines, boxes and ellipses 300 megahertz (MHz) processor, • 50 fill patterns for bar charts, box plots, pie charts, • Non-parameter tests: t-tests, ANOVA * • Alignment and position tools pharmacological research and * 256 MB of system memory, data, execute powerful analytical methods and create industry-specific area plots and free-form boxes and ellipses • One-way, two-way, three-way ANOVA • Draw lines, ellipses, boxes, arrows 100 MB of available hard disk space SigmaPlot enables us to analyze and • Edit font when using text as symbol • Repeated measures * • Layering options CD-ROM drive, • Over 16 million custom colors • Access new lines, fills, and symbols directly from graph prop- • Rates and proportions * 800x600 SVGA/256 color display or better or field-specific graphs. Use built-in macros as provided or use these sort through large amounts of data erties dialog, toolbar, legend page, and the symbol dialog box • Inset graphs inside one another • Correlation * • Selection of graph objects Software macros as a base to create your own macros. Share the power of to create and publish graphs that • Survival analysis (Kaplan-Meir, Cox Regression) * • Right-click property editing • Windows 2000, Windows XP, or Windows Vista; • Power and sample size analysis * • Color schemes Internet Explorer 6 or higher; SigmaPlot with less experienced users by tailoring the SigmaPlot can be transposed to manuscripts • Paste graphic objects from other programs Office 97 or higher (for Excel Integration, * New Features added in SigmaPlot 11 • Graph page rulers Paste to Powerpoint Slide, Insert Graphs into Word and other macros). interface to your application with macros. Create custom dialog boxes, and directly submitted to publications • Adjustable snap-to grids menu choices and forms to help guide novice users through a session. - the product is that user friendly and great! I can’t wait to upgrade to Tap into SigmaPlot’s capabilities from external sources that have Visual SigmaPlot 11. For more information, visit us at www.systat.com - Carmen Cuffari, Basic embedded, including Microsoft Word and Excel or custom software Exact Graphs and Data Analysis applications. Run a macro script in Microsoft Word or Excel that calls Pediatric Gastroenterologist, on SigmaPlot to access data, generate a graph and embed your report. Baltimore, MD North, Central & South Germany and Austria: UK and Ireland: India: Australia and New Zealand : America: Systat Software GmbH Systat Software, Inc. Cranes Software International Ltd. Cranes Software International Pty Ltd. With SigmaPlot’s OLE automation, you get unlimited flexibility. Systat Software, Inc. Schimmelbuschstr 25 UK Branch Office 4th Floor, Block 1, Level 6, College House 1735 Technology Drive, Suite 430 D-40699 Erkrath Germany 24, Vista Centre, 50 Salisbury Road, Shankar Narayan Bldg, 25, M.G. Road, 552 Lonsdale Street, Melbourne, 3000 San Jose, CA 95110 USA Phone: +49.2104.9540 Hounslow, - TW4 6JQ, London, UK. Bangalore, 560001, Karnataka, India Phone: 800-797-7401 Fax: +49.2104.95410 Australia +44-(0)208-538 0128 Fax: 800-797-7406 E-mail: [email protected] Phone: Phone: +91-80-41120000 Phone: +61 3 9670 8997 Email: [email protected] Fax: + 44-(0)208-538 0273 Fax: +91-80-4123 1274 Fax: +61 3 9602 5050 Email: [email protected] Email: [email protected] Email: [email protected] Distributors available in other countries www.systat.com Trial downloads available at www.systat.com © 2008 Systat Software, Inc.