sign in sign up
<<
Home , Adjudin, Amitabha Mukhopadhyay, Amitabh Joshi, Anoop Swarup, Anuranjan Anand, Bhaskar Saha

CONFIDENTIAL (For use of Fellows of the Academy only)

The National Academy of Sciences,

NOMINATIONS Valid for Consideration for Election to Fellowship – 2017

Section of Biological Sciences BOOK - II

ANIMAL SCIENCES (Structural, Developmental, Functional, Genetical, Ecological, Behavioural, Taxonomical and Evolutionary Aspects)

MEDICAL & FORENSIC SCIENCES (Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human , Reproduction , Neurosciences, Molecular Medicine)

5, Lajpatrai Road, Allahabad-211002

The National Academy of Sciences, India

NOMINATIONS Valid for Consideration for Election to Fellowship – 2017

Section of Biological Sciences BOOK - II

CONTENTS

ANIMAL SCIENCES 291 - 339 (Structural, Developmental, Functional, Genetical, Ecological, Behavioural, Taxonomical and Evolutionary Aspects)

MEDICAL & FORENSIC SCIENCES 340 - 437 (Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human genetics, Reproduction Biology, Neurosciences, Molecular Medicine)

5, Lajpatrai Road, Allahabad-211002

(I)

ANIMAL SCIENCES

AGRAWAL, Nirupama 307 MUKHOPADHYAY, Arnab 297 BALASINOR, Nafisa Huseni 308 NALLUR, Ramachandra Basappa 298 BANDYOPADHYAY, Probir Kumar 291 PETER, M.C. Subhash 299 BARAL, Rathindranath 309 PRAKASH, Soam 322 BHADURY, Punyasloke 292 RAISUDDIN, Sheikh 313 CHANDRA, Goutam 324 RAMACHANDRAN, Sundararaj 329 CHAUHAN, Manmohan Singh 293 RAMESH, Saraf Rajagopalaiahsetty 300 CHAUHAN, Ramswaroop Singh 325 ROY, Bishnupada 301 DAS, Manoj Kumar 310 ROY, Jagat Kumar 323 DINESH, Diwakar Singh 294 SAVARIAR, Vincent 336 GHOSH, Sukla 326 SENGUPTA, Pinaki Prasad 314 GOSWAMI, Umesh Chandra 327 SHARMA, Deepak 302 GOVINDARAJU, Archunan 332 SHARMA, Ramesh C. 330 GUPTA, Neelima 295 SHARMA, Vijay Kumar 337 HALDAR, Chandana 333 SINHA, Ravindra Kumar 303 HUSSAIN, Syed Ainual 311 SUBBIAH, Poopathi 315 JADHAO, Arun Govindraoji 318 SUKUMAR, Raman 304 JAIN, Subodh Kumar 328 SWARUP, Anoop 338 KADARKARAI, Murugan 334 TRIPATHI, Bhupendra Nath 316 KAMARAJU, Raghavendra 319 TRIVEDI, Ritu 317 KAR, Devashish 335 VENKATARAMAN, Krishnamoorthy 305 KAR-CHOWDHURI, Debapratim 320 VENUGOPALAN, Vayalam Purath 331 KUMAR, Pradeep 296 WUDAYAGIRI, Rajendra 339 MATHUR, Premendu Prakash 321 YENUGU, Suresh 306 MISRA, Aditya Kumar 312

MEDICAL & FORENSIC SCIENCES

ADIGA, Satish Kumar 407 CHAKRABARTI, Sasanka 344 BAJPAI, Minu 340 CHAKRABARTI, Subhabrata 391 BAL, Chandra Sekhar 341 CHAKRABORTY, Soumen 410 BANERJEE, Monisha 372 CHANDAK, Giriraj Ratan 392 BANERJEE, Soma 342 CHATTOPADHYAY, Debprasad 393 BASHYAM, Murali Dharan 408 CHATTOPADHYAY, Koushik 411 BASU, Sandip 409 CHAUDHURI, Swapna 412 BHATTACHARYA, Jayanta 389 CHAUHAN, Shyam Singh 345 BHATTACHARYYA, Maitree 390 CHHIBBER, Sanjay 430 BHUMA, Vengamma 343 CHIPLUNKAR, Shubhada Vivek 346 BISWAS, Jyotirmay 429 CHOUDHURY, Nabajyoti 413 (II)

CHOWDHURY, Rukhsana 347 MISHRA, Amit Kumar 359 COLAH, Roshan Behram 394 MISRA, Ramnath 401 DAS, Kusal Kanti 373 MUKHOPADHYAY, Satinath 421 DAS, Nilay Kanti 348 NALLARI, Pratibha 433 DAS, Sanjeev 374 NAMPERUMALSAMY, Venkatesh Prajna 384 DAS, Satya Narayan 395 NATH, Gopal 360 DASH, Debabrata 349 PADHY, Rabindra Nath 422 DEEPAK, Kishore Kumar 350 PARTHASARATHY, Satishchandra 434 DUTTA, Ranjna 375 PATURU, Kondaiah 402 GANGADHAR, Nanjundaiah 376 PAUL, Goutam 361 GANGENAHALLI, Gurudutta Ugraiah 414 PAUL, Jaishree 385 GARG, Pankaj 377 RAJAMMA, Usha 362 GARG, Ravindra Kumar 415 RAMACHANDRAN, Balaraman 363 GHATAK, Ashim 378 RANA, Surinder Singh 364 GHOSH, Deepa 351 RANI, Rajni 435 HALDER, Ashutosh 396 RAY, Arunabha 423 HARINARAYAN, Chittari Venkata 352 REDDY SHETTY, Prakasham 403 HUSAIN, Nuzhat 397 SADAKSHARAM, Jayachandran 386 JULKA, Pramod Kumar 416 SAGAR, Rajesh 365 KAKKAR, Poonam 398 SALUJA, Daman 436 KALIMUTHUSAMY, Natarajaseenivasan 379 SAXENA, Sandeep 366 KANNABIRAN, Chitra 431 SENGUPTA, Sharmila 367 KAR, Shantanu Kumar 399 SETH, Pankaj 368 KATARE, Om Prakash 380 SHARMA, Aman 404 KAUR, Gurcharan 417 SHARMA, Jai Bhagwan 369 KAUR, Indu Pal 353 SHUKLA, Sangeeta 424 KHULLAR, Madhu 418 SINGH, Mahendra Pratap 425 KOYAKUTTY, Manzoor 381 SINGH, Sunit Kumar 405 KULKARNI, Mahesh Jagdish Rao 382 SINGH, Surender 426 KUMAR, Arun 400 SOUNDARAPANDIAN, Kannan 387 KUMAR, Ashok * 419 SRIVASTAVA, Deep Narayan 370 KUMAR, Lalit 354 TANDON, Salil 388 KUMAR, Rajeev 383 TOTEJA, Gurudayal Singh 406 KUMAR, Rakesh 355 TRIPATHI, Anil Kumar 437 MAHESHWARI, Monika 356 TRIPATHI, Arvind 427 MALHOTRA, Rajesh 357 VALECHA, Neena 371 MANDAL, Nripendranath 432 VUTHALURU, Seenu 428 MEHROTRA, Ravi 420 MISHRA, Akhilesh Chandra 358 (III)

ANIMAL SCIENCES (Structural, Developmental, Functional, Genetical, Ecological, Behavioural, Taxonomical and Evolutionary Aspects)

BANDYOPADHYAY, PROBIR KUMAR (b 1959), Professor, Department of Zoology, University of Kalyani, Kalyani, West Bengal

Member of the NASI: Yes (YON 2017, Animal Sciences)

Professor P.K. Bandyopadhyay has been nominated as a member of NASI in the year 2014. During his research career, 25 students have been awarded Ph.D. under his supervision and he has published more than 130 papers on animal taxonomy. Professor Bandyopadhyay‘s current research pertains to fish diseases and its plant based control measures. In 2014, he had been able to bring a breakthrough in his research findings when he and his team isolated and characterized the bioactive compound, the oleic acid from Carica papaya seed and used the product as aqua-soluble drug in treating fish bacterial disease in-vivo (Ghosh and Bandyopadhyay, 2016). Further, he again proved his potency in the field by establishing antiprotozoan activity of bioactive compounds of fresh garlic bulb over trichodinid ciliates affecting ornamental goldfish (Saha and Bandyopadhyay, 2017). Apart from fishery sciences, he did a great deal of work on identification and description of new species of protozoan parasites of fish and other group of vertebrates and invertebrates. His work on histopathological alteration of the goldfish, Carassius auratus, due to myxozoan infection with special reference to scanning electron microscopic observation (Saha and Bandyopadhyay, 2017) is unique and first in the field of parasitological research on Ornamental fish. Proposer: Prof. Wasim Ahmad, Seconder: Dr. H. Pathak Ten Best Publications: 1. Saha, M., Bandyopadhyay, P.K. (2017): Phytochemical screening for identification of bioactive compound and antiprotozoan activity of fresh garlic bulb over trichodinid ciliates affecting ornamental goldfish. Aquaculture, Elsevier, doi.10.1016/j.aquacu (if=1.893, ci=nil). 2. Saha, M., Bandyopadhyay, P.K (2016) :Studies on histopathological alteration of three major organs of the goldfish,Carassius auratus L., of India due to myxozoan infection with special reference to scanning electron microscopic observation. Parasitolo (if=2.027, ci=nil). 3. Saha, M., Bandyopadhyay, P.K (2016): First report of some known Trichodinella epizootica Šramek- Hušek, 1953, and Tripartiella Lom, 1959 from the cultured Oranda Gold Fish (Carassius auratus auratus) in India. Zootaxa.(Magnolia press) 4184 (1): 130–14 (if=0.994, ci=01). 4. Mitra, A., Bandyopadhyay, P.K., Gong, Y. (2012) :Studies on trichodinid and chilodonellid Ciliophorans (Protozoa:Ciliophora) in the Indian freshwater and estuarine fishes with description of Trichodinella sunderbanensis sp.nov.and Trichodina nandusi s (if=2.027, ci=06). 5. Mitra, A.K., Bandyopadhyay, P.K. (2005): First records of ectoparasitic African trichodinids (Ciliophora: Peritrichida) in a cichlid fish Oreochromis mossambicus (Peters 1852) from the Churni river system, West Bengal, India. Animal Biology 56 (3): 323 (if=0.879, ci=08). 6. Bandyopadhyay, P. K., Mitra A.(2004): Observations on two new species of Nematocystis Hessé, 1909 (Protozoa: Monocystidae) from earthworms (Annelida: Oligochaeta) of West Bengal, India. Animal Biolology 55 (2): 133-139. (if=0.879, ci=13). 7. Bandyopadhyay, P.K., Mitra, A.K. (2005): Stomatophora cloptoni sp. n.(Apicomplexa: Eugregarinida), from seminal vesicle of an Indian Earthworms. Acta Protozool. (2005) 44:385-388. (if=1.491, ci=07). 8. Bandyopadhyay, P.K., Roy Choudhuri, U.S.,Biswas, Gargi. (2004): Description of two new species of Acephaline Gregarine (Protozoa:Apicomplexa: Eugregarinida), Apolocystis chotonagpurensis sp. n. and Stomatophora janovy sp. n. From Earthworms (Annelida (if=1.491, ci=10). 9. Mitra, A.K., Bandyopadhyay, P.K. (2005): Trichodina haldari sp. n. and Paratrichodina bassonae sp. n. (Ciliophora: Peritrichida) from Indian fresh water fishes”. Act Protozool. 45: 289 – 294 (if=1.491, ci=11). 10. Bandyopadhyay, P. K., Mitra A. K. (2004): Observations on two new species of Monocystis Stein, 1848 (Protozoa: Apicomplexa: Monocystidae) Monocystis darjeelingensis sp.n. and M. ranaghatensis sp.n. from earthworms (Annelida: Oligochaeta) of West Bengal (if=1.491, ci=11).

291

BHADURY, PUNYASLOKE (b 1979), Associate Professor, Indian Institute of Science Education and Research Kolkata (IISER Kolkata)

Member of the NASI: No (YON 2017, Animal Sciences)

Taxonomic intractability is one of the major problems in metazoan groups that inhabit terrestrial and marine domains. The candidate has effectively used molecular tools to resolve taxonomic intractability in one of the metazoan groups represented by the Phylum Nematoda. Prof. Bhadury has developed DNA barcoding as an effective tool for rapid identification of free-living nematodes across marine realms and for the first time addressed and resolved long standing question in biogeography, such as cosmopolitan distribution of marine benthic metazoans using molecular microbial tools (Bhadury et al 2006a, Bhadury et al 2006b, Bhadury et al 2008) which could be highly useful for delineating metazoan . He has conclusively shown that phytoplankton which is key to marine primary production are more diverse and harbor cryptic species in global ocean basins than previously thought of (Samanta and Bhadury 2016). This finding has consequences for coastal primary production. One of the long standing questions pertaining to arsenic cycling in the Bengal Delta Plains (BDP) has been addressed by him. He has now clearly proved long standing hypothesis, that arsenic mobilization and subsequent contamination of ground water aquifers with As is controlled by dissolved organic carbon pool, in particular petroleum hydrocarbons (Ghosh et al 2015a, 2015b).With robust experimental evidence he has now shown that arsenite oxidizing bacteria which are key to controlling As toxicity in ground water aquifers are indeed present in BDP aquifers and that they require the DOC for biotransformation of As species (e.g. Ghosh et al 2014, Ghosh et al 2015b). Proposer: Prof. Tapas K. Kundu, Seconder: Prof. Ten Best Publications: 1. Bhadury P, Austen MC, Bilton DT, Lambshead PJD, Rogers AD and Smerdon GR (2006b): Development and evaluation of a DNA barcoding approach for the rapid identification of nematodes Marine Ecology Progress Series 320: 1-9 (if=2.4, ci=110). 2. Bhadury P, Austen MC, Bilton DT, Lambshead PJD, Rogers AD and Smerdon GR (2006a): Molecular detection of marine nematodes from environmental samples: overcoming eukaryotic interference. Aquatic Microbial Ecology 44: 97-103 (if=2.109, ci=30). 3. Bhadury P, Austen MC, Bilton DT, Lambshead PJD, Rogers AD and Smerdon GR (2008): Evaluation of combined morphological and molecular techniques for marine nematode (Terschellingia spp.) identification. Marine Biology 154: 509-518 (if=2.375, ci=54). 4. Bhadury P, Bik HM, Austen MC, Lambshead JD, Smerdon GR and Rogers AD (2011): Molecular diversity of fungal phylotypes co-amplified alongside nematodes from coastal and deep-sea marine environments. PLoS One 6:e26445 (if=4.411, ci=17). 5. Samanta B and Bhadury P (2014): Analysis of diversity of chromophytic phytoplankton in a mangrove ecosystem using rbcL gene sequencing. Journal of Phycology 50:328-340 (if=2.536, ci=8). 6. Ghosh D, Bhadury P and Routh J (2014): Diversity of arsenite oxidizing bacterial communities in arsenic-rich deltaic aquifers in West Bengal, India. Frontiers in Microbiology DOI: 10.3389/fmicb.2014.00602 (if=4.165, ci=12). 7. Ghosh D, Routh J and Bhadury P (2015b) :Characterization and microbial utilization of dissolved lipid organic fraction in arsenic impacted aquifers (India). Journal of Hydrology 527: 221-233 (if=3.043, ci=6). 8. Ghosh D, Routh J and Bhadury P (2015a): Elemental and biomarker characteristics in a Pleistocene aquifer vulnerable to arsenic contamination in the Bengal Delta Plain, India. Applied Geochemistry 61: 87- 98 (if=2.468, ci=8). 9. Land P, Jamie S, Findlay H, Girard-Ardhuin F, Sabia R, Reul N, Piolle J-F, Bertrand C, Quilfen Y, Salisbury J, Vandemark D, Bellerby R and Bhadury P (2015): Salinity from space unlocks satellite-based monitoring of ocean acidification. Environment (if=5.3, ci=19). 10. Samanta B and Bhadury P (2016): A comprehensive framework for functional diversity patterns of marine chromophytic phytoplankton using rbcL phylogeny. Scientific Reports 6:20783 DOI:10.1038/srep20783 (if=5.578, ci=1).

292

CHAUHAN, MANMOHAN SINGH (b 1960), Director, ICAR Cental Institute for Research on Goats, Makhdoom, Mathura (UP).

Member of the NASI: No (YON 2017, Animal Sciences)

Dr.Manmohan Singh Chauhan, working as Director, has significantly contributed towards the development of simple method for In vitro production (IVF) of embryos in cattle, buffalo, goat and yak; production of 4 embryonic stem cell lines in buffalo and goat; ovum pick up - IVF technology in cattle; animal cloning in buffalo using simple hand guided cloning technology, produced several elite cloned buffaloes. He is ‘Fellow of National Academy of Agricultural Sciences’, ‘Fellow of National Academy of Dairy Sciences of India’. He has been Principal Investigator of 11 mega projects granted to him as Principal Investigator by different agencies such as DBT (Govt. India), NAIP and NF, ICAR, New Delhi. He has guided 8 Doctoral and 9 Master’s students. He is recipient of ICAR-Rafi Ahmed Kidwai Award (ICAR), DBT Overseas Long Term Associate ship Award, ICAR-Team Award, Dr. Labhsetwar Award by ISSRF, Certificate of Merit Award for Exemplary Research by Virginia Tech., USA, Prof. G.P. Talwar Middle Career Scientist Award by ISSRF. During his DBT overseas fellowship program, he worked as PDF for 1 year & 3 months in Virginia Tech, Blacksburg, USA. He has imparted 6 Training for scientists and faculties. He has also organized 3 International Conferences. Over 125 research papers (http://www.ncbi.nlm.nih.gov/pubmed/ ?term=chauhan+MS+Karnal), 2 books has been published by him. He has visited different laboratories in the USA, Canada and Germany. He is member of many professional societies, member of many peer review committees, Task Force at the national and International level Proposer: Dr. Dheer Singh, Seconder: Dr. Subeer S Majumdar Ten Best Publications: 1. Chauhan MS,------Madan ML.(1998): In vitro maturation and fertilization, and subsequent development of buffalo (Bubalusbubalis) embryos: effects of oocyte quality and type of serum. Reproduction Fertility Development.;10(2):173-7. (if=2.135, ci=99). 2. Chauhan MS, Palta P, Das SK, at al.(1997): Replacement of serum and hormone additives with follicular fluid in the IVM medium: effects on maturation, fertilization and subsequent development of buffalo oocytes in vitro. Theriogenology. 48(3):461-9. (if=2.041, ci=57). 3. Chauhan MS, Anand SR.(1990): Effect of egg yolk lipids on the freezing of goat semen.Theriogenology. Nov;34(5):1003-13. (if=2.041, ci=42). 4. Chauhan, M. S., Nadir, S, et al. (1999): Bovine follicular dynamics, oocyte recovery, and development of oocytes microinjected with a green fluorescent protein construct. Journal of Dairy Science, 82(5), 918- 926. (if=2.854, ci=26). 5. Zandi, M., Muzaffar, M.,Chauhan, MS* (2014): WNT3A signalling pathway in buffalo (Bubalusbubalis) embryonic stem cells. Reproduction, Fertility and Development, 26(4), 551-561. (if=2.135, ci=7). 6. Verma, V., -----,.Chauhan, M. S*.(2007): Isolation and characterization of embryonic stem cell-like cells from in vitro-produced buffalo embryos. Molecular Reproduction and Development, 74(4), 520-529. (if=2.141, ci=73). 7. George A, ------, Chauhan MS*. (2011): Production of cloned and transgenic embryos using buffalo (Bubalusbubalis) embryonic stem cell-like cells isolated from in vitro fertilized and cloned blastocysts. Cellular Reprograming. 13(3):263-72. (if=1.462, ci=35). 8. Palta P, Chauhan MS.(1998): Laboratory production of buffalo (Bubalusbubalis) embryos. Reproduction Fertility & Development. 10(5):379-91 (if=2.135, ci=67). 9. Selokar, N. L., Chauhan, M. S., et al., (2014): Hope for restoration of dead valuable bulls through cloning using donor somatic cells isolated from cryopreserved semen. PLoS One. ;9(3):e90755. doi: 10.1371/journal.pone.0090755 (if=3.234, ci=21). 10. Shah SM, ------, Chauhan MS*. (2015): Development of buffalo (Bubalusbubalis) embryonic stem cell lines from somatic cell nuclear transferred blastocysts. Stem Cell Research 15 (2015) 633–639. (if=4.018, ci=3).

293

DINESH, DIWAKAR SINGH (b 1959), Scientist, Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna

Member of the NASI: Yes (YON 2017, Animal Sciences)

Dr. Diwakar Singh Dinesh has made a significant contribution in popularization of science in the field of vector biology and control. He published 61 articles in his credit; 49 in National and International journals having high impact factor and citations, 10 book chapters and 2 bulletins working since 1987. He established several facts like(i)Plant sources of fructose to sandfly in nature (ii) Landing and biting rhythm of sandflies in natural conditions (ii) Migratory populations from endemic area(Vaishali district) of Kal-azar established the disease in nonendemic area of Patna district. (iii) CDC light as most productive tool for collection of wild sandflies (iv) None effectiveness of Long Lasting Insecticide treated Nets (LLINs) to control sandflies at house hold level (v) Development of resistance against DDT to sandflies of Bihar (vi) Brick chimney ash (rabish) with lime as suitable environmental management material for control of sandflies by sealing the breeding site through skirting indoor walls. (vii) Plant extract having insecticidal effect to sandflies; applied for patency in Indian Council of Medical Research, New Delhi. Dr. Dinesh is one of the awardees of ICMR International Fellowship of Senior Biomedical Scientist 2015. He conducted several intramural and extramural projects sponsored by National and International agencies. He presented his research papers in India and abroad. He contributed in Kala-azar elimination programme in Bihar. He is member of several scientific committees. He popularised the science by delivering radio talk on popular scientific articles, writing script for telecast in doordarshan and organising meetings for Patna- chapter, NASI. Proposer: Prof. , Seconder: Dr. Vishwa Mohan Katoch Ten Best Publications: 1. Dinesh DS, … & Katoch VM (2000):Screening sand flies for natural infection with Leishmania donovani, using a non-radioactive probe based on the total DNA of the parasite. Ann Trop Med & Parasitol,94: 447-451 (if=1.203, ci=30). 2. Dinesh D S, Ranjan A, Palit A, Kishore K & Kar SK (2001): Seasonal and nocturnal landing/biting behavior of Phlebotomus argentipes (Diptera: Psychodidae). Ann Trop Med & Parasitl, 95: 197-202 (if=1.203, ci=52). 3. Kishore K, Kumar V, Kesari S, Dinesh DS, Kumar AJ, Das P & Bhattacharya SK (2006): Vector Control in Leishmaniasis. Indian Journal of Medical Research, 123: 467 – 472 (if=1.446, ci=96). 4. Dinesh DS, …& Coosemans M (2008): The efficacy of indoor CDC light traps for collecting the sandfly Phlebotomus argentipes, vector of Leishmania donovani. Med Vet Entomol 22, 120-123 (if=2.242, ci=27). 5. Dinesh DS,…& Coosemans M (2008): Long–lasting insecticidal nets fail at household level to reduce abundance of sand fly vector Phlebotomus argentipes in treated houses in Bihar, (India). Trop Med Int Health 13(7): 953-958 (if=2.519, ci=39). 6. Bart O,…Dinesh DS,…& Davies C (2008): Vector control by insecticide-treated nets in the fight against in the Indian subcontinent, what is the evidence? Trop Med Int Health, 13 (8): 1-13 (if=2.519, ci=62). 7. Clements MF,…,Dinesh DS,…& Rogers ME (2010): Measurement of recent exposure to Phlebotomus argentiopes, the vector of Indian Visceral Leishmaniasis,by using human antibody responses to sand fly saliva Am J Trop Med Hyg, 82 (5) 801-807 (if=2.453, ci=37). 8. Picado A,…, Dinesh DS,…& Davies C (2010): Effect of village-wide use of Long-Lasting Insecticidal Nets on visceral leishmaniasis vectors in India and Nepal: a cluster randomized trial. PLoS Negl Trop Dis, 4(1): e587 (1-9) (if=3.948, ci=54). 9. Picado A,…, Dinesh DS,… &Davies C. (2010): Phlebotomies argentipes seasonal patterns in India and Nepal. Journal of medical Entomology, 47 (2):283-286 (if=1.712, ci=27). 10. Dinesh DS,…& Coosemans M (2010): Insecticide Susceptibility of Phlebotomus argentipes in Visceral Leishmaniasis Endemic Districts in India and Nepal. PLoS Negl Trop Dis 4 (10): e859 (if=3.948, ci=45). 294

GUPTA, NEELIMA (b 1955), Professor & Dean Students Welfare, MJP Rohilkhand University, Bareilly

Member of the NASI: Yes (YON 2017, Animal Sciences)

PROF. (MRS) NEELIMA GUPTA, National (1) & State (2) Awardee is an internationally acclaimed taxonomist (blood parasites specific, parasites in general). Several species have been dedicated in her name. Her innovative contributions on morpho-taxonomy, molecular taxonomy, protein profile and scanning electron microscopy are based on 60 species of 22 genera (50 new species, 3 sub species) making her the recipient of the PRESTIGIOUS LIFE TIME NATIONAL AWARD, EK JANAKI AMMAL NATIONAL AWARD ON ANIMAL TAXONOMY (Ministry of Environment & Forests, Government of India). She is the recipient of more than 38 awards including 2 state awards (Vigyan Ratna and Dr. SAH Abidi Krishi Vaigyanik Puraskar). She has published several papers with leading global scientists. She was awarded the “Centre of Excellence” by the State Government and has executed research projects worth Rs. 1.3 crores. She was invited as Lead Speaker in many national and international conferences (George Washington University, USA, Poland, Egypt, Japan, Singapore, China) and became a global leader having international collaborations with five continents of the globe. She is presently working on fish fauna of river Ramganga (UPCAR research project). Her contributions have unfolded many mysteries of parasites and have greatly benefitted fish farmers and scientists. She has a research experience of 40 years, contributing 6 books, 175 research papers, 300 abstracted in conferences (481). She has presented her findings in 135 symposia (26 international, 109 national). Based on my personal knowledge of her own merits and expertise, she has my strong recommendations. Proposer: Prof. M Shamim Jairajpuri, Seconder: Prof. Wasim Ahmad Ten Best Publications: 1. Gupta, Neelima & Jairajpuri, D. S. (1982): Trypanosoma aligaricus n. sp. from the freshwater murrel,Ophiocephalus punctatus Bloch. Arch. Protistenkd., 125: 109-114. (if=3.045 JCR, 9.05 NAAS, ci=2). 2. Gupta, Neelima & Jairajpuri, D. S. (1983): Trypanosoma batrachi Qadri, 1962 and its effect on the biochemical composition of the blood of Clarias batrachus. Acta Protozool., 22:79-85. (if=1.491 JCR, 1.96 Research Gate,0.581 SJR, 28 H-Index, 6.84, NAAS, 148.36 ICV, ci=5). 3. Gupta, Neelima & Gupta, D. K. (1988): Prevalence of trypanosomes in freshwater fishes of Northern India: Cross transmission experiments on host specificity. Arch. Protistenkd., 136: 203-209 (if=3.045 JCR, 9.05 NAAS, ci=3). 4. Gupta, Neelima, Gupta, D. K. & Yadav, P. (1998): New records of some haemoparasites affecting Puntius ticto (Pisces: Cyprinidae) in India: Observations on interaction and displacement of species. Res. Rev. Parasitol. Spain. 58: 103-108. (if=1.129 JCR, 5.79 ICV, ci=2). 5. Gupta, Neelima and Bhaskar, Manju & Gupta, D.K. (2009): Gastro-intestinal invasion in Hemidactylus flaviviridis with a new species of Parapharyngodon. (Oxyuroidea: Parapharyngodonidae). Zootaxa. 2165: 39-51 (if=0.994 JCR, 1.16 Research Gate, 0.62 SJR, 6.91 NAAS, ci=9). 6. Gupta, D. K. & Gupta, Neelima (2010): A haemogram of Clarias batrachus parasitized by two species of haemoflagellates (Trypanosoma batrachi Qadri, 1962 and Trypanosoma haematalis n. sp.) as an indicator of infectivity. Reviews in Fish. Sc. 18(2): 17 (if=2.032 JCR, 2.54 Research Gate,7.87 NAAS, ci=2). 7. Gupta, Neelima and Bhaskar, Manju and Gupta, D.K. (2012): Macroenvironmental influence on Hepatozoon lacertilis infectivity to lizard Hemidactylus flaviviridis. J. Env. Biol., 33 : 127-132. (if=0.56 JCR, 0.31 SJR, 6.55 NAAS, ci=3). 8. Gupta, Neelima, Singhal, P. and Gupta, D.K. (2012): Population dynamics of Pallisentis (Acanthocephala) in relation to host sex of Channa. J. Env. Biol., 33: 195-199. (if=0.56 JCR, 0.31 SJR, 6.55 NAAS, ci=4). 9. Gupta, Neelima, Bhaskar, M, and Gupta, D.K. (2013): Ecological attributes of Hepatozoan lacertilis Gupta et al., 2011 susceptibility in Indian lizards, Hemidactylus flaviviridis (Gekkonidae) and Calotes versicolor (A (if=0.921 JCR, 0.46 SJR, 6.82 NAAS, ci=1). 10. Gupta, Neelima, Gupta, D.K., Singhal, P. (2015): Description of Pallisentis (Brevitritospinus) punctati n. sp. (Acanthocephala:Quadrigyridae) from Channa punctatus in Bareilly, Uttar Pradesh, India. Iran J Parasitol 10(4):605-616 (if=0.872 JCR, 6.69 NAAS, ci=1).

295

KUMAR, PRADEEP G (b 1962), Scientist G, Rajiv Gandhi Centre For Biotechnology, Thiruvananthapuram

Member of the NASI: No (YON 2017, Animal Sciences)

He demonstrated the presence and reorganizations of microdomains in membranes during epididymal maturation, capacitation and acrosome reaction (11, 12, 24, 55, 60, 71 and 102) and that these membrane modifications and dependent on plasma membrane located NOX system (4, 6, 7, 13, 15, 18, 53, 55, 65). He also showed that defective expression of NOX in spermatozoa is associated with human male factor infertility and that neutralizing NOX can interfere with sperm functioning in fertile men (7, 26-29, 45-48, 63, 67). He generated proteome profiles of raft and non-raft proteins of human sperm and identified strong association between the absence of some proteins and male factor infertility (85, 91- 93, 96-101). He has developed a prototype protein-chip for molecular diagnosis of male factor infertility. Using the 1st wave of in mouse as a model, he has generated epigenetic, transcriptome, mirnome and proteome during the onset and progression germline stem cell differentiation in testis and have identified key pathways and regulatory molecules involved in the processes of gernline stem cell maintenance, initiation of differentiation and meiotic entry (95). He has develop technology for trans-differentiation of spermatogonial stem cell into embryonic stem cell like (ES-like) cells, which could further be converted into ectodermal, mesodermal and endodermal lineages in culture. At present, he is targeting select miRNAs to alter the expression level of several genes in one go and to reprogram germline stem cells in culture to produce haploid cells in vitro. Proposer: Prof. GP Talwar, Seconder: Prof. K. Muralidhar Ten Best Publications: 1. Kumar GP, Seerwani N, Laloraya M, Nivsarkar M, Verma S and Singh A (1990): Superoxide dismutase as a regulatory switch in mammalian testicular steroidogenesis. Biochem. Biophys. Res. Commun. 173(1), 302 308. (if= 3.25, ci=21). 2. Kumar GP, Laloraya M and Laloraya MM (1991): Superoxide radical level and superoxide dismutase activity changes in maturing mammalian spermatozoa. Andrologia 23(2), 171 175 (if=1.63, ci=25). 3. Kumar GP, Malini Laloraya, Cong-Yi Wang, Quin-Guo Ruan, Abdoreza Davoodi-Semiromi, Kuo-Jang Kao, and Jing-Xiong She (2001): The Autoimmune Regulator (AIRE) Is a DNA-binding Protein J. Biol. Chem., Vol. 276, Issue 44, 41357-41364 (if=6.56, ci=131). 4. Shukla S, Jha RK, Laloraya M and Kumar GP (2005): Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa. Biochem. Biophys. Res. Commun. 331(2), 476-483 (if=3.25, ci=27). 5. Sreesha S, Radhakrishnan K, Indu S and Kumar PG (2014): Dramatic changes in 67 during Initiation of first wave of spermatogenesis in Mus musculus testis: Global regulatory insights generated by microRNA-mRNA network analysis. Biol. Reprod. 91 (3) 69, 1-11. (doi: 10.1095/biolreprod.114.119305). (if=3.471, ci=12). 6. Devi AN, Kumar ATR, Pillai SM, Jayakrishnan K and Kumar PG (2015): Expression profiles of NPHP1 in the germ cells in the semen of men with male factor infertility. Andrology 3, 685-693 (if=2.515, ci=1). 7. Indu S, Sekhar SC, Jeeva S, Anilkumar TR, Pillai SM, Laloraya M and Kumar PG (2015): Aberrant expression of DYNLT1 is associated with human male factor infertility. Mol Cell Proteom 14(12):3185-95 (if=6.564, ci=1). 8. Varghese DS, Chandran U, Soumya A, Pillai SM, Jayakrishnan K, Reddi PP and Kumar PG (2016): Aberrant expression of TAR DNA binding protein-43 is associated with spermatogenic disorders in human males. Reprod. Fertil. Dev. 28(6):713-22 (if=2.583, ci=2). 9. Chandran U, Indu S, Anilkumar TR, Devi AN, Khan I, Srivastava D and Kumar PG (2016): Expression of Cnnm1 and its association with stemness, cell cycle and differentiation in spermatogenic cells in mouse testis. Biol. Reprod 95(1), 7 (if=3.471, ci=1). 10. Radhakrishnan K, Bhagya KP, Anilumar TR, Devi AN, Sengottaiyan J and Kumar PG (2016): Autoimmune regulator (AIRE) is expressed in spermatogenic cells and it altered the expression of several nucleic acid binding and cytoskeletal proteins in GC1-spg spermatogonial cells. Mol Cell Proteomics 15(8), 2686-2698. (if=6.564, ci=0).

296

MUKHOPADHYAY, ARNAB (b 1972), Staff Scientist V, National Institute Of , New Delhi

Member of the NASI: No (YON 2017, Animal Sciences)

Aging predisposes humans to age-related diseases like diabetes, and neurodegenerative disorders. Understanding its molecular basis is key to develop interventions that will prevent these diseases and prolong healthy lifespan. Arnab started his lab in NII seven years ago. Having a strong background in aging biology, Arnab has used a unique combination of genetics, cell biology and genomics to understand how nutrient signaling controls lifespan and modulate aging. He is also one of the few Indian PIs who use Caenorhabditis elegans as a model system. He has identified novel genes that when knocked down convinces animals to believe that food is limiting, even under food-replete condition, to mount a conserved cytoprotective response leading to increased longevity. He has elucidated the complex transcriptional and posttranscriptional regulations of important Forkhead family transcription factors that regulate the aging process. He has shown that Rifampicin analogs can increase life span and delay aging, a finding that has tremendous translation potential. His findings have been published in some of the most respected and leading journals of the field. I believe that Arnab has set up an internationally competitive, collaborative, multidisciplinary program and has several interesting research leads which are bound to generate much excitement in the field. Overall Arnab is showing great potential as a future leader in his chosen area of research and a future fellowship in NASI will help him immensely to foster new collaborations and help him to disseminate his research to a wider and select group of scientific audience. Proposer: Dr. , Seconder: Dr. Vinay Kumar Nandicoori Ten Best Publications: 1. Maity S, Rajkumar A, Matai L, ....Mukhopadhyay A, Sengupta S, Chakraborty C (2016): Oxidative homeostasis regulates response to reductive Endoplasmic Reticulum stress through translation control. Cell Reports 16:851-865.# Senior authors (if=7.8, ci=0). 2. Singh A, Kumar N, Matai L, Jain V, Garg A and Mukhopadhyay A (2016): A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity. Aging Cell 15, pp694–705. (if=5.76, ci=3). 3. Kumar N, Jain V, Singh A, Jagtap U, Verma S and Mukhopadhyay A (2015): Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans. Oncotarget 6(39):41418-33. #Equal contribution (if=5, ci=3). 4. Golegaonkar S, Tabrez SS, ...... Kulkarni MJ and Mukhopadhyay A (2015): Rifampicin reduces Advanced Glycation End products and activates DAF-16 to increase life span in Caenorhabditis elegans, Aging Cell 14(3):463-73 (if=5.76, ci=7). 5. Chamoli M, Singh A, Malik Y, Mukhopadhyay A (2014): A novel kinase regulates Dietary Restriction- mediated longevity in C. elegans. Aging Cell 13(4):641-55. (if=5.76, ci=14). 6. Padmanabhan S, Mukhopadhyay A, Narasimhan S, Tesz G, Czech MP, Tissenbaum HA (2009): A PP2A regulatory subunit, PPTR-1, regulates C. elegans insulin signaling by modulating AKT-1 phosphorylation. Cell 136:939-951 (if=28.7, ci=124). 7. Mukhopadhyay A, Deplancke B, Walhout AJM, Tissenbaum HA (2008): Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat Protocols 3(4):698 (if=9.64, ci=131). 8. Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA (2006): Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nature Genetics 38(2):251-257. *Co-first authors (if=31.61, ci=322). 9. Mukhopadhyay A, Deplancke B, Walhout AJM, Tissenbaum HA (2005) C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metabolism 2:35-41. (if=17.03, ci=99). 10. Mukhopadhyay A, Vij S, Tyagi AK (2004) Overexpression of a zinc-finger protein gene from rice confers tolerance to cold, dehydration, and salt stress in transgenic tobacco. Proceedings National Academy of Sciences USA 101(16):6309-6314. (if=9.6, ci=380).

297

NALLUR, RAMACHANDRA BASAPPA (b 1958), Professor and Chaiman, University of Mysore, Mysuru

Member of the NASI: No (YON 2017, Animal Sciences)

In Human Genetics the findings are: a) identification of 'advanced maternal grandmother's age' as the potential risk factor for Down syndromes; b) consanguineous uncle –niece marriages as risk factor for congenital heart diseases in South India; c) Identification of new recombination hotspot- pseudoautosomal region 3 (PAR3) between the X and Y chromosomes in humans; d) Identification of five new genes involved in Dyslexia by copy number variations (CNVs); e) Establishment of novel SNPs in new genes associated with Congenital Heart Diseases, Asthma, Dyslexia and Chromosome nondisjunction; f) Identification type 2 diabetes mellitus disease risk genes by genome wide CNV scans; g) Role of ADAM33 interactive pathway in asthma; h) CNV studies to propose new migratory routes of humans with two settlements and influence on miRNA gene regulation; i) Establishment of ‘University of Mysore Genome Centre’ database. Significant contributions in Drosophila Genetics include: a) Genetics of second chromosome specific indirect flight muscle mutants generated in D. melanogaster which have an impact on myofibril assembly and function. b) Evolution of new introgressed genetic systems, the short-lived and long-lived Cytoraces in the environs of laboratory with high rate of substitution. c) Whole genome and transcriptome with ChIP- seq analysis of the Cytoraces to demonstrate the 'recombinational speciation’ for rapid genomic changes and ‘adaptive genome evolution' during the 30 year long-range interracial hybridization experiment. Proposer: Prof. H.A.Ranganath Seconder: Prof. Mewa Singh Ten Best Publications: 1. Avinash M V, Sangeetha V, Kusuma L, Megha M, Raviraj V S,Dinesh S M, and NB Ramachandra, (2015): Global spectrum of Copy Number Variations reveals genome organizational plasticity and proposes new migration routes. PLoS ONE 10(4): e0121846. doi:10. (if=4.09, ci=02). 2. Jahromi SR, Mahesh PA, Jayaraj BS, Subbarao MV, Holla AD, Sangeetha V, and NB Ramachandra, (2014). Serum Levels of IL-10, IL-17F and IL-33 in Patients with Asthma: A Case-Control Study, Journal of Asthma, 51(10): 1004-1013. (if=1.848, ci=19). 3. Avinash MV, Marieta S, Prakash P and NB Ramachandra, (2013): Genome-wide copy number scan identifies disruption of PCDH11X in developmental dyslexia. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 9999:1–9. DOI 10.1002/ajmg.b (if=3.270, ci=14). 4. Avinash M Veerappa, Marita Saldanha, Prakash Padakannaya and NB Ramachandra, (2013):Copy Number Variation analysis in humans reveal previously identified X chromosome Transposed Region (XTR) in Y-chromosome to be a pseudoautosomal region 3 (PAR3). Fu (if=3.3, ci=12). 5. Mahdi Bijanzadeh, NB. Ramachandra, P. A. Mahesh, M R. Savitha, B. S. Manjunath and B. S. Jayaraj, (2010):Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population, Lung 188:415-422 (if=1.899, ci=44). 6. Smitha R and NB Ramachandra, (2006): Parental consanguinity increases Congenital Heart Diseases in South India. Annals of Hum. Biol. 33(5/6):519-928. (if=1.713, ci=49). 7. Malini S S and NB Ramachandra, (2006): Influence of advanced age of maternal grandmothers on Down syndrome. BMC Medical genetics. 7: 4 (8 pages) Feb. 14th . (if=2.84, ci=65). 8. Harini BP and NB Ramachandra, (2003): Evolutionary experimentation through hybridization under laboratory condition in Drosophila: Evidence for Recombinational Speciation. BMC , 3,20 (1-19). (if=3.52, ci=21). 9. Upendra Nongthomba and NB Ramachandra, (1999): A direct screen identifies new flight muscle mutants on the Drosophila second chromosome. Genetics, USA, 71-83. (if=4.836, ci=25). 10. Ramachandra, NB and HA Ranganath,(1986):The Chromosomes of two Drosophila races: D. nasuta nasuta and D. nasuta albomicana. IV. Hybridization and karyotype repatterning. Chromosoma, 93: 243- 248. (if=4.979, ci=36).

298

PETER, M.C. SUBHASH (b 1961), Professor and Dean, Head, Hon. Director, University of Kerala, Thiruvananthapuram

Member of the NASI: No (YON 2017, Animal Sciences)

For the past two and half decades Dr. Peter has been doing research in stress physiology and endocrinology mainly in the area of stress physiology and endocrinology of fish. He has successfully presented evidence for a thyroid hormone (TH)–driven sodium pump regulation in mitochondria-rich cells of fish gills where it promotes osmotic competence in varied environments. Extensive work on many fish models provided him with evidences for identifying a role for THs in stress response of fish. An for invited review on this account was published in General and Comparative Endocrinology which was one of the hottest articles of 2011. His concept of inter-hormonal interference between THs and cortisol explains the interactions of these hormones with cortisol and adrenaline in stress response in fish (Peter and Peter 2011, GCE). He has later conceptualized a novel phenomenon of ease and ease response as an adaptive mechanism that favors animals to mitigate their stress response (Peter, 2013 GCE). He has involved in Science management served as an Editor of GCE since 2008. His later research on ease physiology provided him evidences to identify the invertebrate endocrinology of ease response in fish. He has organized many International Conferences, Workshops in Comparative Endocrinology and Stress Physiology. Dr. Peter has established an Inter -University Centre for Evolutionary and Integrative Biology in the University of Kerala that offers M.Sc and M.Phil courses and Ph.D. programme in Integrative Biology with support of RUSA, Government of Kerala. Proposer: Prof Atanu Kumar Pati, Seconder: Prof. Edathil Vijayan Ten Best Publications: 1. Babitha, G. S. and Peter, M.C.S. (2010): Cortisol promotes and integrates the osmotic competence of the organs in North African Catfish (Clarias gariepinus Burchell): Evidence from in vivo and in situ approaches. Gen. Comp. Endocrinol. 168, 14-21 (if=2.86, ci=25). 2. Peter M. C. S. (2011): “INVITED REVIEW”. The role of thyroid hormones in stress response of fish. Gen. Comp. Endocrinol. 172, 198-210 (if=2.7, ci=54). 3. Peter M. C. S. and Rejitha V. (2011): Interactive effects of ambient acidity and salinity on thyroid function during acid and post-acidic acclimation of air-breathing fish Gen. Comp. Endocrinol. 174, 175- 183 (if=3.87, ci=8). 4. Peter M. C. S., J. Leji., V.S. Peter (2011): Ambient salinity modifies the action of triiodothyronine in the air-breathing fish, Anabas testudineus Bloch: Effects on mitochondria-rich cell distribution. Gen.Comp. Endocrinol. 171, 225-231 (if=3.87, ci=15). 5. Peter V. S. and Peter M. C. S. (2011): “INVITED REVIEW” The interruption of thyroid and interregnal and the inter-hormonal interfrerence in fish: Does it promote physiologic adaptation or maladaptation Gen. Comp. Endocrinol. 174, 249-258. (if=3.87, ci=11). 6. Ings, J. S., George, N., Peter, M. C. S., Servos, M. R. and Vijayan, M. M. (2012): Venlafaxine and atenolol disrupt epinephrine-stimulated glucose production in rainbow trout hepatocytes. Aquatic Toxicol, 106, 48–55. (if=3.73, ci=14). 7. V.S. Peter, G.S Babitha, S.E Wendelaar Bonga, M.C.S Peter. (2013): Carbaryl exposure and recovery modify the interrenal and thyroidal activities and the mitochondria-rich cell function in the climbing perch Aquatic Toxicol. 126, 306-313. (if=3.51, ci=7). 8. George, N., V.S. Peter, M.C.S Peter. (2013): Physiologic implications of inter-hormonal interference in fish: Lessons from the interaction of adrenaline with cortisol and thyroid hormones Gen. Comp. Endocrinol.Comp. Endocrinol 181, 122-129 (if=3.03, ci=9). 9. M.C.S. Peter (2013): Understanding the adaptive response in vertebrates: The phenomenon of ease and ease response during post-stress acclimation Gen. Comp. Endocrinol. 181, 59-64 (if=3.03, ci=8). 10. Rejitha V. and M.C S Peter. (2013): Adrenaline and triiodothyronine modify the iron handling in the freshwater air-breathing fish Anabas testudineus Bloch. Gen. Comp. Endocrinol. 181,130-138 (if=3.03, ci=1).

299

RAMESH, SARAF RAJAGOPALAIAHSETTY (b 1954), CEO and Academic Advisor, Mahajana First Grade College, Mysuru

Member of the NASI: No (YON 2017, Animal Sciences)

Dr.Ramesh chose Drosophila nasuta subgroup as research model. He studied intraspecific and interspecific chromosomal variations, biochemical genetics of adult isoenzymes, male accessory gland secretions and larval salivary secretions to understand genetic differentiation. He established: • X-chromosomes are homosequential, while chromosomes2 and 3 differ due to inversions and transpositions. • Correlation between isoenzyme allelic variation and taxonomic relationship. • Absence of correlation between size or number of cells in salivary gland and increased secretion. • Pattern polymorphism of larval salivary and adult male accessory gland secretions and chromosomal linkage. He studied fitness, eye pigments, sexual selection, localization of mutations and sperm precedence in D.nasuta and D.n.albomicans, their mutants and established . • Fitness and sexual selection superiority of certain mutants over wild-type. • Seven of eight mutant genes are on chromosome2 and one on chromosome3. • Last mated male sperm precedence in doubly mated females is not ubiquitous. Working on learning and memory in Drosophila, screening and validating influence of phytochemicals on radiation induced damages, biochemical and genetic system of wild-type, transgenic Alzheimer’s (AD) and Parkinson disease (PD) models of D.melanogaster, he established. • Olfactory memory status in wild-type flies • Age-associated changes in neurotransmitters and structural changes in olfactory learning neural system • Learning and memory in transgenic AD • Ameliorative effects of natural antioxidants on memory impairment and loss • Role of neurotoxicity in PD development • Neuroprotective effect, prevention of loss of circadian rhythmicity in transgenics • Radioprotective potential against gamma radiation toxicity Proposer: Prof. H. A. Ranganath, Seconder: Prof. Mewa Singh Ten Best Publications: 1. Ramesh, S. R. and Kalisch, W.E. (1988). "Glue proteins in Drosophila nasuta". Biochem. Genet. 26: 527-541. (ci=15). 2. Ramesh, S. R and Shivanna, N. (1999): “SDS-PAGE pattern polymorphism of X-chromosomal glue proteins in the natural populations of two Drosophila nasuta subgroup species”. Biochem. Genet. 37: 1- 22. (if=0.797, ci=9). 3. Ravi Ram, K and Ramesh, S. R. (2001):“Male accessory gland secretory proteins in a few members of the Drosophila nasuta subgroup”. Biochem. Genet. 39: 99-115. (if=0.625, ci=9). 4. Hosamani, R., Ramesh, S. R and Muralidhara, M. (2010): “Attenuation of Rotenone-Induced Mitochondrial Oxidative Damage and Neurotoxicty in Drosophila melanogaster Supplemented with Creatine”. Neurochem. Res. 35: 1402-1412. (if=2.608, ci=36). 5. Shruti, B and Ramesh, S. R. (2013): “Last mated male sperm precedence in doubly mated females is not ubiquitous: evidence from sperm competition in the laboratory populations of Drosophila nasuta nasuta and Drosophila nasuta albomicans”. J. Genet. 92: (if=1.013, ci=2). 6. Haddadi, M., Jahromi, S. R., Shivanandappa, T and Ramesh, S. R. (2013): Decalepis hamiltonii root extract attenuates the age-related decline in the cognitive function in Drosophila melanogaster. Behavioural Brain Res. 249: 8-14. (if=3.298, ci=7). 7. Haddadi, M., Jahromi, S. R., Sagar, B. K. C., Patil, R. K., Shivanandappa, T and Ramesh, S.R.( 2014): Brain Aging, Memory Impairment and Oxidative Stress: A study in Drosophila melanogaster. Behavioural Brain Research 259: 60-69. (if=3.29, ci=26). 8. Jahromi, S. R., Haddadi, M., Shivanandappa, T and Ramesh, S.R. (2015):“Modulatory effect of Decalepis hamiltonii on ethanol-induced toxicity in transgenic Drosophila melanogaster model of Parkinson’s disease”. Neurochem. International 80: 1-6. (if=3.092, ci=4). 9. Jahromi, S. R., Haddadi, M., Shivanandappa, T and Ramesh, S.R. (2015): “Attenuation of Neuromotor Deficits by Natural Antioxidants of Decalepis hamiltonii in Transgenic Drosophila Model of Parkinson's Disease”. Neuroscience. 293: 136-150. (if=3.357, ci=11). 10. Haddadi, M., Nongthomba, U., Jahromi, S. R and Ramesh, S. R. (2016): Transgenic Drosophila model to study apolipoprotein E4-induced neurodegeneration. Behavioural Brain Res. 301: 10-18. (if=3.028, ci=1). 300

ROY, BISHNUPADA (b 1960), Professor, North-Eastern Hill University, Shillong

Member of the NASI: Yes (YON 2017, Animal Sciences)

I am personally acquainted with the scientific work of Prof. Bishnupada Roy who has more than 31 years of research experience in the field of parasitology involving taxonomy and chemotherapy of helminth parasites. He has described surface topography of more than 30 different species of helminth parasites and has showed that micro-topography of helminth parasites is species specific, thus provided an additional set of criteria of taxonomic value. Prof. Roy contributed extensively in the field of molecular diagnosis by developing species specific primers and DNA barcodes for several food borne zoonotic helminths and also described 3 new species of helminth parasites. Prof. Roy has developed a new technique for processing of soft biological tissues for scanning electron microscopy. The method is in use globally in many SEM Labs because of its significant features - it is simple, rapid and economical. He also established anthelmintic potential of several medicinal plants consumed by different tribes in North-East India to cure intestinal helminth infections. At present his group is trying to unveil the mechanism of action of the isolated active compounds of these plants and also to evaluate their toxic effect, if any, on the consumers in Northeast India. Six students have been awarded Ph.D. under his supervision and 8 more are working for their degree. Proposer: Prof. Anupam Chatterjee, Seconder: Prof. Nirmalendu Saha Ten Best Publications: 1. Tandon, V., Pal, P., Roy, B., Rao, H.S.P. & Reddy, K.S. (1997): In vitro anthelmntic activity of root tuber extract of Flemingia vestita, an indigenous plant in Shillong, India. Parasitology Research, 83: 492- 498. (if=2.327, ci=87) 2. Roy, B. & Tandon, V. (1996) : Effect of root tuber extract of Flemingia vestita, a leguminous plant, on Artyfechinostomum sufrartyfex and Fasciolopsis buski : a scanning electron microscopy study. Parasitology Research, 82 : 248-252. (if=2.327, ci=34) 3. Roy, B. & Tandon, V. (1992) : Seasonal prevalence of some zoonotic infections in cattle and pigs in a humid sub-tropical montane zone in India. Veterinary Parasitology, 41 : 69-76. (if=2.545, ci=30) 4. Challam, M., Roy, B. & Tandon, V. (2010): Effect of Lysimachia ramosa (Primulaceae) on helminth parasites: Motility, mortality and scanning electron microscopic observations on surface topography. Veterinary Parasitology, 214: (if=2.545, ci=27) 5. Dasgupta, S., Roy, B. & Tandon, V. (2010): Ultrastructural alterations of the tegument of Raillietina echinobothrida treated with the stem bark of Acacia oxyphylla (Leguminosae). Journal of Ethnopharmacology. 172(2): 568-571. (if=2.939, ci=24) 6. Roy, B., Dasgupta, S. & Tandon, V. (2009): Ultrastructural observations on Fasciolopsis buski and its alterations caused by shoot extract of Alpinia nigra. Microscopy Research and Technique. 72(2): 61-66. (if=1.17, ci=20) 7. Giri, B. R. & Roy, B. (2014). Resveratrol induced structural and biochemical alterations in the tegument of Raillietina echinobothrida. Parasitology International, 63: 432-437. (if=2.111, ci=13) 8. Roy, B & Giri, B. R. (2016). α-Viniferin and resveratrol induced alteration in the activities of some energy metabolism related enzymes in the cestode parasite Raillietina echinobothrida, Acta Tropica,154: 102-106. (if=2.27, ci=1) 9. Dey, S., Basubaul, T. S., Roy, B & Dey, D. (1989) : A new rapid method of air drying using Tetramethylsilane for scanning electron microscopy”. Journal of Microscopy, 156 : 269-261. (if=2.15, ci=63) 10. Roy, B. & Tandon, V. (1991): “Usefulness of Tetramethylsilane in the preparation of helminthparasites for scanning electron microscopy”. Revista di Parasitologia, 8(L2): 405-413. (if=N/A, ci=20)

301

SHARMA, DEEPAK (b. 1957) Professor, Jawaharlal Nehru University,New Delhi

Member of the NASI: No (YON 2017, Animal Sciences)

Dr Deepak Sharma’s extensive research focused on electrophysiology, biochemistry and pharmacology of brain Ageing. His work has made significant contribution to the understanding of the interrelationship between the ageing-related alterations in biochemical (oxidative parameters) and electrophysiological activity of the ageing brain. How changes in oxidative stress parameters may lead to electrophysiological ageing (decline in multiple unit action potential and electroencephalographic activity) of the brain has been clarified. Concerning the pharmacology of ageing (i.e. antiageing medicine) his work has made significant contributions to the understanding of the mechanism of action of a variety of candidate antiageing drugs: Centrophenoxine, acetyl-L-carnitine, L-deprenyl, dehydroepiendrsterone. Antiageing action of hormones like estradiol, progesterone has also been clarified. Outstanding aspect of the work is how these substances counter normal electrophysiological ageing. His focus on Ethanofarmacological studies reveals herbal antiageing substances such as Baccopa curcumin and Fisetin where it has been shown that 2 herbal substances do have potential to counteract normal as well as aluminium-induced enhancement (acceleration) in ageing and neurotoxicity. Sleep deprivation promotes ageing is also another very interesting aspect of his work. Another important aspect of Dr. Deepak Sharma’s research concerns relationship between ageing and epilepsy: Ageing accelerates propensity for epilepsy while phytoproducts like Baccopa, curcumin and Fisetin protects against seizures; neurosteroid hormone (DHEA) has antiepileptic action. A part of Dr. Sharma’s research work also deals with correlative studies between : lipofuscin and neuronal electrical activity, and maternal malnutrition and brain development. Dr Sharma has significant contribution in several areas of the field of Animal Science. Proposer : Prof. Rameshwar Singh, Seconder : Prof. Kailash Chand Ten Best Publications : 1. Sharma D. Maurya A. Singh R. (1993): Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. NeurobiolAging.14 (4):319-30. (CI=39). 2. Kaur J, Sharma D, Singh R (2001): Acetyl-l-carnitine enhances Na+,K+-ATPase Glutathione-S- transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions. Neurosci Lett. Mar; 301(1) 1-4 (CI=65). 3. Amar jyoti and Deepak Sharma (2006): Neuroprotective role of Bacopa monniera against Aluminium – induced oxidative stress in the hippocampus of rat brain. Neurotoxicology 27:451-57 (CI=97). 4. Kiran Bala, B.C Tripathy and Deepak Sharma (2006): Neuroprotective and anti-ageing effect of curcumin in aged rat brain regions. Biogerontology 7:81-89 (CI=148). 5. Singh R, Jenny K, Singh S1 and Sharma D (2008): Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats Biogerontology 9:153-162 (CI= 29). 6. Deepak Sharma, Pallavi Sethi, Ezaj Hussain and Rameshwar Singh (2008): Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress Na+,K+ ATPase and Protein kinase C in adult and old rat brain. Biogerontology 10:489–502 (CI=52). 7. Pallavi Sethi, Amar jyoti, Ezaj Hussain and Deepak Sharma (2008):Aluminium induced electrophysiological, biochemical and cognitive modifications in the hippocampus of ageing Rats. Neurotoxicology 29:1069-1079 (CI=76). 8. Pallavi Sethi, Amar Jyoti, Ejaz Hussain and Deepak Sharma (2009): Curcumin attenuates Aluminium - induced functional neurotoxicity in rats Pharm. Biochem. Behav. 93:31-39 (CI=26). 9. Sharma S, Debases Sahu, Hasi Rani Das, Deepak Sharma (2011): Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress. Food and Chemical Toxicology 49(12):3395-406 (CI=21). 10. Monika Mishara, Rameshwar Singh, Somnath Mukherjee and Deepak Sharma (2013): Dehydroepiendrosterone’s antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transportes. Epilepsy research 106:83-89. ( CI= 03). IMPACT FACTOR: Pharm.Biochem.Behav-2.781; Neuroscience letter-2.189; Epilepsy and Behavior-2.30 Biogerontology-3.55; Neurotoxicology-3.37; J. Ethanopharmacology-2.998; Neurobiology of Aging-6.634 , Epilepsy Research – 2.4, . Food and Chemical Toxicology-2.894 (h index -41 a per ISI web of knowledge) RG-32.34.

302

SINHA, RAVINDRA KUMAR (b 1954), Professor and Head, Department of Zoology, Patna University, Patna

Member of the NASI: Yes (YON 2017, Animal Sciences)

The nominee saved the Ganges dolphin from extinction in India. The fishermen used to kill the dolphins to extract body oil as fish attractant. He discovered an alternative to the dolphin oil from fish scraps which led to significant reduction in the dolphin poaching (Sinha, 2002). He conducted continuous surveys using country boats in the entire length of the Ganges and most of its tributaries in India and Nepal to assess the distribution range, population status, ecological requirements and threats to the dolphin (Smith et al. 1994; Sinha 1997; Sinha et al, 2000; Sinha 2000, Sinha and Sharma 2003; Sinha and Kannan 2014). Based on the analyses of mitochondrial cytochrome b and nuclear interphotoreceptor retinoid-binding protein (IRBP) gene sequence of the 15 Ganges dolphins, and its closer molecular relationship with the baleen whales, he regarded the species as a “living fossil” (Verma et al.,2004). His research and conservation efforts, attracted the attention of both national and international policy makers, executives and scientific communities. In a positive response, Government of India designated the dolphin as National Aquatic Animal in 2009. He developed a Conservation Action Plan for the Ganges dolphin in 2010 (Sinha et al. 2010), which was enthusiastically accepted by the Government of India. The nominee has been conferred “Padma Shri” in 2016, the Swarna Jayanti Puruskar of the National Academy of Sciences, India in 2000, and the Order of the Golden Ark by His Royal Highness Prince Bernhard of the Netherlands in 1999. Proposer: Prof. Madhav D. Gadgil, Seconder: Dr. Pradeep Das Ten Best Publications: 1. Kannan, K., Tanabe, S., and Tatsukawa, R. and Sinha R.K.(1994): Biodegradation capacity and residue pattern of organochlorines in Ganges river dolphins from India. Toxicological and Environmental Chemistry, 42. 249-261 (if=2.309, ci=72). 2. Sinha R.K.(1997): Status and Conservation of Ganges river dolphin in Bhagirathi-Hooghly river systems in India. Int. J. Ecol. and Env. Sc. 23 : 343-355. (if=1.2, ci=26). 3. Senthilkumar, K., Kannan, K., Sinha, R.K., Tanabe, S., and Giesy, J.P.(1999): Bioaccu Profiles of Polychlorinated Biphenyl Congen and Organochl Pesticides in Ganges River Dolphins. Environ Toxicol and Chem, 18. ( 7). 1511-1520 (if=2.309, ci=94). 4. Sinha, R. K. et al. (2000): Status and distribution of the Ganges susu in the Ganges R Syst of India and Nepal. In ``Biol and Conserv of Freshwater Cetaceans in Asia,'' eds R.R. Reeves, B.D. Smith, and T. Kasuya. Occas papers, IUCN SSC 23: 54-61 (if=0.0, ci=29). 5. Sinha, R. K., (2002): An alternative to dolphin oil as a fish attractant in the Ganges River system: Conservation of the Ganges River dolphin. Biological Conservation, Vol.107(2): 253-257 (if=3.566, ci=22). 6. Verma, S. K., Sinha, R. K., and Singh, Lalji. (2004) Phylogenetic position of Platanista gangetica: insights from the mitochon cyt b and nuclear interphotoreceptor retinoid-binding protein gene sequences. Mole Phylo and Evol. 33; 280-288 (if=4.018, ci=17). 7. Yeung, L. W. Y., Yamashita, N., Taniyasu, S., Lam, P. K. S., Sinha, R.K., Borole, D.V., and Kannan, K. (2009): A survey of PFCs in surface water and biota including dolphins from the Ganges River and in other water bodies in India. Chemo, 76(1):55-62 (if=3.054, ci=92). 8. Kannan, K., Praamsma, M. L., Oldi, J. F., Kunisue, T. and Sinha, R. K .(2009): Occurrence of perchlorate in drinking water, ground water, surface water and human saliva from India. Chemosphere, Vol. 76 (1): 22-26 (if=3.054, ci=100). 9. Pozo, K., Harner, T., Lee, S. C., Sinha, R. K., Sengupta, B., Loewen, M., Geethalakshmi, V., Kannan, K. and Volpi, V. 2011. Assessing Seasonal and Spatial Trends of Pers Organ Pollut (POPs) in Indi Agri Reg using PUF Disk PAS. Env Pollut 159, 646-53 (if=3.135, ci=75). 10. Sinha, R. K. and Kannan, K. (2014): Ganges River dolphin: An overview of Biology, Ecology, and Conservation status in India. AMBIO, 43:1029-1046 (if=2.973, ci=3).

303

SUKUMAR, RAMAN (b 1955), Professor, Indian Institute of Science, Bengaluru

Member of the NASI: No (YON 2017, Animal Sciences)

Professor Raman Sukumar has made significant, original contributions to the ecology, behaviour and conservation of the Asian elephant. His early work on the ecology of elephant-human interactions was the pioneering work globally on the subject of conflicts between animals and humans within an ecological- evolutionary framework; this work was published as a monograph by Cambridge University Press (Sukumar 1989). This study provided the biological basis for the observed male-biased raiding of agricultural crops and other conflicts with humans by elephants (Sukumar and Gadgil 1988), and provided a framework for management of such conflicts (Sukumar 1991). Since then he has expanded his work to cover almost all facets of elephant biology, including foraging ecology using stable isotope techniques (Sukumar and Ramesh 1992), role of elephants in seed dispersal in tropical forests (Sekar and Sukumar 2013), population dynamics (Sukumar et al. 1998, Chelliah et al. 2013), and evolutionary history (Vidya et al. 2009), vocalization (Nair et al. 2009), sexual selection (Chelliah and Sukumar 2013, 2015), reproductive physiology (Ghosal et al. 2012, 2013), and conservation ecology (Baskaran et al. 2013). In 2003, Sukumar published a monograph that has been described as “the most comprehensive synthesis in the English language” of the biology of elephants (review in Quarterly Review of Biology), and followed this up in 2011 with a cultural history of the elephant from ancient times to the present. He has also made seminal contributions to tropical forest ecology and climate change which he synergizes with his work on elephants. Proposer: Prof. , Seconder: Prof. H.A. Ranganath Ten Best Publications: 1. Sukumar, R. and Gadgil, M. (1988):Male-female differences in foraging on crops by Asian elephants. Animal Behaviour 36: 1233-1235. (if=3.169, ci=125). 2. Sukumar, R. (1990): Ecology of the Asian elephant in southern India. II. Feeding habits and crop raiding patterns. Journal of Tropical Ecology 6: 33-53 (if=0.975, ci=204). 3. Sukumar, R. (1991): The management of large mammals in relation to male strategies and conflict with people. Biological Conservation 55: 93-102. (if=3.985, ci=142). 4. Sukumar, R., Ramesh, R., Pant, R.K. and Rajagopalan, G. (1993): A 13C record of late Quaternary climate change from tropical peats in southern India. Nature, 364: 703-706. (if=38.138, ci=255). 5. Watve, M.G. and Sukumar, R. (1995): Parasite abundance and diversity in mammals: correlates with host ecology. Proceedings of the National Academy of Sciences (USA) 92: 8945-8949. (if=9.423, ci=70). 6. Condit, R., Ashton, P.S., Baker, P., Bunyavejchewin, S., Gunatilleke, S., Gunatilleke, N., Hubbell, S.P., Foster, R.B., Itoh, A., LaFrankie, J.V., Lee, H.S., Losos, E., Manokaran, N., Sukumar, R. and Yamakura, T. (2000): Spatial patterns in the distr (if=34.661, ci=1033). 7. Rasmussen, L.E.L., Krishnamurthy, V. and Sukumar, R. (2005): Behavioural and chemical confirmation of the preovulatory pheromone, (Z)-7-dodecenyl acetate, in wild Asian elephants: its relationship to musth. Behaviour, 142: 351-396. (if=1.401, ci=27). 8. Vidya, T.N.C., Sukumar, R. and Melnick, D.J. (2009): Range-wide mtDNA phylogeography yields insights into the origins of Asian elephants. Proceedings of the Royal Society B, 276: 893–902. (if=4.823, ci=39). 9. Sekar, N. and Sukumar, R. (2013): Waiting for Gajah: an elephant mutualist’s contingency plan for an unreliable megafaunal disperser. Journal of Ecology 101: 1379–1388. [Winner of the Harper Prize for the best paper in Journal of Ecology in 2013] (if=6.18, ci=15). 10. Chelliah, K., and Sukumar, R. (2013):The role of tusk, musth and body size in male-male competition among Asian elephants (Elephas maximus). Animal Behaviour 86: 1207-1214. (if=3.169, ci=13).

304

VENKATARAMAN, KRISHNAMOORTHY (b 1955), Former Director, ZSI; Senior Scientific Consultant, National Institute of Sustainable Coastal Management, Chennai.

Member of the NASI: No (YON 2017, Animal Sciences)

Dr Venkataraman has made significant contributions to animal taxonomy and conservation of endangered animals. His discoveries on Cladocera and Scleractinian coral and associated fauna are of keystone, biomonitoring and evolutionary significance.His acclaimed work on coral systematics and associated fauna has been immensely contributing to understanding taxonomy,distribution and evolutionary significance.He started his career in freshwater, migrated to potamoplankton and finally dived into the coastal and marine ecosystem especially coral reefs. He is the first certified Dive Master and has been diving throughout the world since 1998. His pioneering underwater studies on Coral reefs have unraveled the status and coral bleaching as well as corals after 2014 tsunami. His study on marine biodiversity of India has lead to consequential increase in marine biodiversity from 12,372 to 21,663 (coral in particular have increased from 218 in 1998 to 577 species in 2015) adding to an increase of fauna of India from 89451 to 97514. With the aid of his Hand Book on Hard corals of India, he trained researchers and managers on status, taxonomy as well as underwater monitoring studies on corals. His effort towards Coral restoration by transplantation from Gulf of Mannar to Gulf of Kachchh is a success story. This has made him a nationally and internationally renowned coral reef researcher. He has discovered a coral species new to science and 351 new records for India. Dr.Venkataraman’s researches have resulted in outstanding contributions to taxonomy, conservation of corals in India and in shaping biodiversity laws and policies. Proposer: Dr. Qaiser Baqri, Seconder: Prof. Wasim Ahemad Ten Best Publications: 1. Venkataraman, K. (1981): Field and Laboratory studies on Daphnia carinata Kind (Cladocera: Daphnidae) from a seasonal tropical pond, Hydrobiol., 78 (3): 221-225 (if=2.321 (2014) %-years, ci=14). 2. Venkataraman, K (1992): I. Cladocera of Keoladeo National Park, Bharatpur and its environs, J. Bombay Nat. Hist. Soc. 89 (1), 17-26 (if=0.26, ci=14). 3. Venkataraman, K. (1995): Cladoceran males from the Indian region, J. Bombay Nat. Hist. Soc. 92: 378-385 (if=0.26, ci=10). 4. Venkataraman, K. (1999): Freshwater Cladocera (Crustacea: Branchiopoda) (ed.) Director Zool. Surv. India, Fauna of West Bengal Part 10: 251-284. (if=-NA-, ci=10). 5. Rajasuriya, A, H Zahir, E.V. Muley, B. R. Subramanian, K. Venkataraman MVM Wafar, SMMH Khan, EMMA Whittingham (2002): Status of coral reefs in South Asia: Bangladesh, India, Maldives, Sri Lanka, Proceedings of the Ninth International Coral Reef Symp (if=-NA-, ci=74). 6. EV Muley, K Venkataraman, JRB Alfred, MVM Wafar, (2002): Status of coral reefs of India, Proceedings of the Ninth International Coral Reef Symposium, Bali, October 23-27, 2002,. 2: 847-853 (if=-NA-, ci=18). 7. Venkataraman, K. and M. Wafar, (2005): Coastal and marine biodiversity of India, Indian J. Mar. Sci. 34 (1): 57-75 (if=0.316, ci=143). 8. Venkataraman, K. and S. S. Latha, (2008) Intellectual property rights, traditional knowledge and biodiversity of India, J. Intell. Prop. Rights 13 (4): 326-335. (if=0.39, ci=14). 9. Venkataraman, K. Coastal and marine wetlands of India, Proc. Taal, (2007): The 12th World Lake Conference, 392-400. (if=-NA-, ci=10). 10. Wafar, M. K Venkataraman, B Ingole, S.A. Khan, P LokaBharathi, State of knowledge of coastal and marine biodiversity of Indian Ocean countries, PLoS One 6 (1), e14613. (if=4.092, ci=40).

305

YENUGU, SURESH (b 1972), Associate Professor, School of Life Sciences, Department of Animal Biology, University of , Hyderabad

Member of the NASI: No (YON 2017, Animal Sciences)

The nominee, Suresh Yenugu is an established investigator in the field of Reproductive Immunology. His laboratory has demonstrated that the antimicrobial peptides of the male reproductive tract exhibit synergistic bacterial killing when used in combination with commonly used antibiotics, thus paving the way for developing strategies to reduce the use of antibiotics to treat infections. His in depth studies on the role of antimicrobial genes in the innate immunity of the male reproductive tract under conditions that mimic an infection established an unconventional function for reproductive tract genes beyond sperm function. The epigenetic mechanisms of antimicrobial regulation demonstrated in his studies opened up the possibility of use of molecules that regulate epigenetic changes to potentiate innate immunity. His studies are of clinical importance which will lead to the use of epigenetic modulators alone or in combination with reproductive tract antimicrobial proteins to boost immune response against reproductive tract infections. His research contributions also led to the identification of many male reproductive tract proteins as potential immuno-contraception targets. His studies showed that knocking down testis specific genes affect sperm function and fertility and this is one of his outstanding contributions in the recent days. Proposer: Prof. Kambadur Muralidhar, Seconder: Prof. Aparna Dutta Gupta Ten Best Publications: 1. Rajesh A and Yenugu S. shRNA mediated ablation of Prostate and Testis Expressed (Pate) messenger RNA and protein results in impaired sperm function and fertility. Andrology (in press) (if=2.5) 2. Narmadha G and Yenugu S. (2016): Immunization against lysozyme-like proteins affect sperm function and fertility in the rat. Journal of Reproductive Immunology. 118:100-108. (if=3.2) 3. Narmadha G and Yenugu S. (2016): In silico and Biochemical Characterization of Lysozyme-like proteins in the rat. PLoS ONE 11(9):e0161909. (if=4.4, ci=0.5) 4. Rajesh A and Yenugu S. (2015): Effect of immunization against prostate and testis-expressed (PATE) proteins on sperm function and fecundity. Journal of Reproductive Immunology. 110:117-129. (if=3.2, ci=1.0) 5. Biswas B, Bhushan S, Rajesh A, Suraj SK, Lu Y, Meinhardt A, Yenugu S. (2015): Uropathogenic Escherichia coli (UPEC) induced antimicrobial gene expression in the male reproductive tract: evaluation of the potential of Defensin 21 to limit infection. An (if=2.5, ci=0.67) 6. Rajesh A, Yenugu S. (2012): Genomic organization, tissue distribution and functional characterization of the rat pate gene cluster. PLoS One. 2012; 7(3):e32633 (if=4.4, ci=1,33) 7. Narmadha G, Muneswararao K, Rajesh A, Yenugu S. (2011): Characterization of a novel lysozyme-like 4 gene in the rat. PLoS One. 6(11):627659 (if=4.4, ci=1.29) 8. Yenugu S, Hamil KG, Radhakrishnan Y, French FS, Hall SH. The androgen regulated epididymis sperm-binding protein, ESC42, is an antimicrobial beta-defensin. Endocrinology. 2004; 145(7): 3165- 3173. (if=4.5, ci=5.71) 9. Yenugu S, Richardson RT, Sivashanmugam P, Wang Z, O’Rand MG, French FS, Hall SH. Antimicrobial activity of Eppin, an androgen regulated sperm bound protein with a whey acidic protein motif. Biology of Reproduction 2004; 71(5): 1484-90. (if=3.8, ci=4.86) 10. Yenugu S, Hamil KG, Birse C.E, Ruben S.M, French F.S, Hall S.H. Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytop (if=4.4, ci=4.2)

306

AGRAWAL, NIRUPAMA (b 1954), Professor, University of Lucknow, Lucknow

Member of the NASI: No (YON 2016, Animal Sciences)

Prof. Agrawal has original contributions in Helminth taxonomy like monogenoideans, digeneans, cestodes and nematodes. She has solved taxonomic problems and established new species, using morphometric analyses (78, 82,83,128) and new genera from marine fishes of Indian east coast (105, 124). Investigations from collections of Great Barrier Reef (91, 92) and South America (99) resulted in description of four new species. Some Indian species were wrongly placed under genera Ancyrocephalus Creplin, 1839 Haliotrema Johnston et Tiegs, 1922 or Urocleidus Mueller, 1934. New genera were established to accommodate dactylogyrids, infecting various fishes. They are Sclerocleidoides Agrawal et al., 2001 (105) (to include Ancyrocephalus etropli Gussev, 1963); Mastacembelocleidus (118) (Ancyrocephalus bam Tripathi, 1959, Urocleidus rhynchobdelli Jain, 1959, Urocleidus heteronchorus Kulkarni, 1969, Haliotrema tandoni Agrawal and Singh, 1982 and Urocleidus raipurensis Dubey et al., 1992); Chandacleidus Agrawal et al., 2006 (125) (Urocleidus recurvatus Jain, 1961), Xenentocleidus (126) (Urocledius xenentodoni Jain, 1961) and Sundanonchus (130) (Urocleidus behuri Agrawal et Singh, 1982). Further a new genus Esmocleidus (Ancyrocephalus esomi Gusev, 1963 and A. chakrabarti Gusev, 1976) was proposed (171) to accommodate three species from Esomus. Their phylogenetic position is established using molecular markers. Invasive potential of monogenoids via fish trade is reported (127, 131, 162, 163). Recently, DNA extraction, PCR, electrophoresis and different bioinformatic tools are used to complement the morphometric analyses and evolutionary aspects for monogenoidean and digenean parasites (165, 169, 175). Rhythmicity of digeneans were studied (166, 167,168). She has also contributed monographs on Monogenoidea and Trematode Metacercaria. Proposer: Prof. R.C.Sobthi, Seconder: Prof. Omkar Ten Best Publications: 1. Agrawal N, Rajvanshi S and Asthana A. (2017): Intraguild interaction among fiveoioxenous congeneric Thaparocleidus sp. (Monogenoidea) infecting freshwater shark Wallago attu Bloch and Schneider, 1801. Journal of Helminthology. 1-8. doi: 10.1017/S002 (if=1.6) 2. Rajvanshi S, Choudhary K and Agrawal, N. (2016): Threading: A novel insilico indagation method for genetic characterization of some diplostomoid metacercariae (Digenea:Diplostomidae Poirier, 1886). Experimental Parasitology.171:71-76. (if=1.86) 3. Ray S, and Agrawal N. (2014):Rhythmicity in the emergence of Cercaria tondani Saxena, 1982, a gymnocephalus cercaria from Lymnea stagnalis (Linnaeus, 1758). Biological Rhythm Research. 46: 299- 305. (if=0.919, ci=2) 4. A Tripathi, S Rajvanshi, and N Agrawal. (2014): Monogenoidea on exotic Indian freshwater fishes. 2. Range expansion of Thaparocleidus caecus and T. siamensis (Dactylogyridae) by introduction of striped catfish Pangasianodon hypophthalmus (Pangasiida (if=0.602, ci=5) 5. KC Pandey, and N Agrawal. (2008): An encyclopaedia of Indian monogenoidea Vitasta Pub. (ci=29) 6. Tripathi A, Agrawal N, and Pandey, KC. (2007): The status of Quadriacanthus Paperna, 1961 and Anacornatus Dubey et al., 1991 (Monogenoidea :Dactylogyridae) with redescription of Q. kobiensis Ha Ky, 1968, new geographical records for Q. bagrae Paper (if=1.86 , ci=4) 7. A Timbao, Kritsky DC, Yuan S, Jianying Z, and Shuhua S, and Agrawal, N. (2006): Diplectanids infesting the gills of the barramundi Lates calcarifer (Bloch) (Perciformes: Centropomidae), with the proposal of Laticola n.g. (Monogenoidea: Diplectan (if=1.316 , ci=21) 8. DC Kritsky, KC Pandey, N Agrawal and SMA Abdullah. (2004): Monogenoids from the gills of spiny eels (Teleostei: Mastacembelidae) in India and Iraq, proposal of Mastacembelocleidus gen. n., and status of the Indian species of Actinocleidus, Urocleid (if=1.271 , ci=30) 9. Agrawal, N and Kritsky, DC. (1998):Neotropical Monogenoidea. 33. Three new species of Ancistrohaptor n.g. (Dactylogyridae, Ancyrocephalinae) on Triportheus spp. (Teleostei, Characidae) from Brazil, with checklists of ancyrocephalines recorded from (if=1.316 , ci=9) 10. Agrawal N. Chisholm LA and Whittington ID.(1996):Pseudohexabothrium taeniurae n.sp. (Monogenea: Hexabothridae from the gills of Taeniura lymna (Dasyatidae) off Heron Island, Great Barrier Reef, Australia. J. Parasitol. 82: 131-136. (if=1.3, ci=5) 307

BALASINOR, NAFISA HUSENI (b 1960), Scientist - F, National Institute for Research in Reproductive Health, Mumbai

Member of the NASI: No (YON 2016, Animal Sciences)

Dr. Balasinor's group has made significant contribution in understanding the intricacies of Male Fertility. Using tamoxifen (SERM) treatment in rat they have demonstrated the role of estrogen in acquisition/maintenance of genomic imprint marks during spermatogenesis. The study showed paternal aberrant imprinting in causing post implantation embryo loss and abnormal placentation in rats. Similarly, they have also reported aberrant paternal imprinting in spermatozoa of male partners of women experiencing recurrent spontaneous indicating association of paternal imprinting with recurrent spontaneous abortions. These studies appear to have immense significance in understanding involvement of paternal imprinting in pregnancy related diseases such as recurrent spontaneous abortions, preeclampsia and intrauterine growth retardation in women. The studies on understanding the molecular mechanism of spermiation and the role of estrogen during spermiation in rats have highlighted that estrogen signaling through its cognate receptor ERβ causes spermiation failure by affecting expression of genes involved in actin cytoskeletal remodeling leading to disruption of tubulobulbar complex and hence spermiation. Her group has also demonstrated that estrogen signaling through its receptors affects fertility. ERα is predominantly involved in the negative feedback regulation of gonadotrophins while ERβ has predominantly testicular effect. Further estrogen signaling through ERα regulates spermiogenesis whereas signaling through ERβ regulates spermiation and spermatocytes apoptosis. These studies help to understand the mechanism through which endocrine disruptors like xenoestrogens may affect male germ line and male fertility. In recognition of her contributions, she was awarded, ICMR Smt. Swaran Kanta Dingley Award, 2009 and ISSRF G.P. Talwar Middle Career Scientist Award in 2011. Proposer: Prof. V. P. Kamboj, Seconder: Dr. Smita D. Mahale Ten Best Publications: 1. Balasinor N*, Gill-Sharma MK, Parte P, D'Souza S, Kedia N, Juneja HS. (2002): Effect of paternal administration of an antiestrogen, tamoxifen on embryo development in rats. Mol Cell Endocrinol.; 190:159-66. (if=2.698, ci=31) 2. D'Souza R, Gill-Sharma MK, Pathak S, Kedia N, Kumar R, Balasinor N*. (2005): Effect of high intratesticular estrogen on the seminiferous epithelium in adult male rats. Mol Cell Endocrinol.;241(1- 2):41-8. (if=2.786, ci=75) 3. Pathak S, Kedia-Mokashi N, Saxena M, D’Souza R, Maitra A, Parte P, Gill-Sharma MK and Balasinor N*. (2009): Effect of tamoxifen treatment on global and Insulin-like growth factor 2-H19 locus specific DNA methylation in rat spermatozoa and its assoc (if=4.11, ci=42) 4. D’Souza S, Pathak S, Upadhyay R, Gaonkar R, D’Souza S, Sonawane S, Gill- Sharma M K and Balasinor NH*. (2009): Disruption of tubulobulbar complex by high intratesticular estrogen leading to failed spermiation Endocrinology 150: 1861–1869 (if=5.3, ci=45) 5. Pathak S, D’Souza R, Ankolkar M, Gaonkar R, Balasinor NH*.(2010): Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Molecular & Cellular Endocrinology 314: 110-7 (if=3.6, ci=30) 6. Upadhyay R, D’Souza R, Sonawane S, Gaonkar R, Pathak S, Jhadav A, Balasinor N H*. (2011): Altered phosphorylation and distribution status -Estradiolof vimentin in rat seminiferous epithelium following 17 treatment Histochemistry and Cell Biol (if=4.7, ci=13) 7. Ankolkar M, Patil A, Warke H, Salvi V, Kedia Mokashi N, Pathak S, Balasinor NH*. (2012): Methylation analysis of idiopathic recurrent spontaneous miscarriage cases reveals aberrant imprinting at H19 ICR in normozoospermic individuals. Fertil Steri (if=4.17, ci=25) 8. Kedia-Mokashi NA, Kadam L, Ankolkar M, Dumasia K, Balasinor NH*.(2013): Aberrant methylation of multiple imprinted genes in embryos of tamoxifen-treated male rats. Reproduction. 146(2):155-68 (if=3.26, ci=03) 9. Kumar A, Dumasia K, Gaonkar R, Sonawane S, Kadam L and Balasinor NH*.;(2015): Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation. Molecular and Cellular Endocrinology 404: 91–101 (if=4.405, ci=05) 10. Dumasia K, Kumar A, Kadam L, Balasinor NH*.(2015): Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats. J Endocrinol.225(3):169-80 (if=4.498, ci=04)

308

BARAL, RATHINDRANATH (b 1962), Senior Scientific Officer in Assistant Director Grade Chittaranjan National Cancer Institute, Kolkata, India

Member of the NASI: No (YON 2016, Animal Sciences)

Nominee is dedicated in the research on ‘Cancer Immunology and Immunotherapy’. His research group is trying improve the dysregulated immunity in tumor host by immunomodulation. The group described a novel glycoprotein from neem leaf, designated as ‘Neem Leaf Glycoprotein’. NLGP restricts murine sarcoma, melanoma and carcinoma by systemic immunomodulation in CD8+ T cell dependent manner. Detail immunobiochemical mechanism are being attempted to elucidate. NLGP prevents aberrant angiogenesis and metastasis in cancer and possess unique tumor microenvironment normalizing property. Present focus of the lab includes, characterization of various tumor microenvironmental events (e.g., stromal/stem cell biology, cellular behavior in tumor hypoxia etc.) and structural determination of NLGP. This molecule is in process of clinical translation. In addition, immunomodulation by interferon alpha 2b was also investigated with special effort to the treatment of renal cell carcinoma patients. Proposer: Dr. Chinmay K. Panda , Seconder: Dr. Syamal Roy Ten Best Publications: 1. Ghosh S, Sarkar M, Ghosh T, Guha I, Bhuniya A, Saha A, Dasgupta S, Barik S, Bose A, Baral R*, Neem leaf glycoprotein generates superior tumor specific central memory CD8+ T cells, Vaccine (in press) (if=3.41, ci=Yet to be cited) 2. Roy S, Lu K, Nayak MK, Bhuniya A, Ghosh T, Kundu S, Ghosh S, Baral R, Dasgupta PS, Basu S. Activation of D2 dopamine receptors in CD133+ve cancer stem cells ...... (2016): J Biol Chem 292, 435- 445. (if=4.26, ci=Yet to be cited) 3. Ghosh T, Barik S, Bhuniya A, Dhar J, Ghosh S, Sarkar M, Guha I, Sarkar K, Chakrabarti P, Saha B, Storkus WJ, Baral R*, Bose A*, (2016): Tumor-associated mesenchymal stem cells inhibit ...... Int J Cancer, 139, 2068-2081. (if=5.50, ci=Yet to be cited) 4. Bose A, Barik S, Banerjee S, Ghosh T, Mallick A, Bhattacharya Majumdar S, Goswami KK, Bhuniya A, Banerjee S, Baral R, Storkus WJ, Dasgupta PS, Majumdar S. (2013): Tumor-derived vascular pericytes anergize T helper cells. J Immunol 191:971-981. (if=5.59, ci=13) 5. Mallick A, Barik S, Goswami KK, Banerjee S, Ghosh S, Sarkar K, Bose A, Baral R. (2013): Neem leaf glycoprotein activates CD8+ T cells to promote ………………. PLoS One, 8, e47434. (if=4.09, ci=21) 6. Bose A, Chakraborty K, Sarkar K, Chakraborty T, Goswami S, Pal S, Baral R(2009): Neem leaf glycoprotein induces perforin mediated tumor cell killing by T and NK cells …………, J Immunother, 32, 42-53. (if=4.84, ci=29) 7. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S. (2008): Dopamine regulates endothelial progenitor cell mobilization from mouse ……………... J Clin Invest. 118, 1380-1389. (if=16.56, ci=97) 8. Baral R* and Chattopadhyay U, (2004): Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. Int Immunopharmacol, 4: 355-366. (if=2.21, ci=85) 9. Baral R, Sherrat A, Das R, Foon KA, Bhattacharya-Chatterjee M, (2001): Murine Monoclonal Anti- Idiotype Antibody as a surrogate Antigen for human Her2/neu. Int J Cancer, 92: 88-95. (if=4.23, ci=27) 10. Foon KA, Lutzky J, Baral R, Yannelli JR, Hutchins L, Teitelbaum A, Kashala OL, Das R, Garrison J, Reisfeld RA, Bhattacharya-Chatterjee M (2000): Clinical and Immune responses in advanced melanoma patients immunized with an anti-idiotype ……….. J Clin (if=8.77, ci=155)

309

DAS, MANOJ KUMAR (b 1957), Scientist E, National Institute of Malaria Research (ICMR), Ranchi

Member of the NASI: No (YON 2016, Animal Sciences)

Dr. M K Das is a trained biomedical scientist in the field of vector borne diseases. He has worked in the remote tribal areas for almost 16 years (Car Nicobar, Andaman & Nicobar Islands) of the country. He was working as the Officer-in-charge MRC Field Station Car Nicobar Island from the year 1990 to 2006. He was deputed to Car Nicobar with a big challenge to control endemic malaria. I am most delighted to feel proud that Dr. Das single handedly planned executed the bioenvironmental malaria control in Car Nicobar and brought down malaria to very low level under the guidance of Late Dr. V P Sharma. This he could do without the use of any insecticide. One of his contributions is the finding of Plasmodium knowlesi from Andaman Nicobar Islands. He is working in the Ranchi, Field Unit of NIMR for the last ten years. He has carried out work on transmission dynamics of malaria, insecticide resistance on malaria vectors, mapping of filariasis in Jharkhand state. His research on Durable Lining, Long Lasting Insecticide Nets (LLINs) leads to the development of novel vector control tools. His studies will help for the elimination of filariasis and malaria from the state vis-à-vis from the country. He has published more than 76 scientific papers in high impact journals. He was awarded ICMR awards for Biomedical research conducted in underdeveloped areas in 2006. He was awarded with the honour of Lt. Governor’s Commendation Certificate at A & N Islands 2015 and also Dr. M.O.T. Iyengar Memorial Award 2015 (ICMR, New Delhi). Proposer: Prof. A P Dash, Seconder: Prof. Y D Sharma Ten Best Publications: 1. Das, M.K., Joshi Hema, Verma A, Singh S S and Adak T (2005): Malaria among Jarawas -the primitive and isolated tribe of Andaman and Nicobar Islands, India Annals Trop Med and parasitol.99(6): 1-8 (if=1.20, ci=8) 2. Das M K, S S Singh, T Adak, K Vasantha and D Mohanty (2005): The Duffy blood group of Jarwas – the primitive and vanishing tribe of Andaman and Nicobar Islands, India. Transf. Med. (15): 237-240 (if=1.68, ci=5) 3. Ahmed A., Das, M.K. Vas Dev, M.A. Saifi, Wajihullah and Y.D. Sharma (2006): Quadruple Mutations in Dihydrofolate Reductase of Plasmodium falciparum Isolates from Car Nicobar Island, India. Antimicrob Agents and Chemother. 50: 1546-1549 (if=4.47, ci=25) 4. Ahmed A, Das M K, Dev V, Wajihullah and Sharma YD (2007): Prevalence of Mutations Associated with Higher Levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India. Antimicrob Agents C (if=4.47, ci=28) 5. Lumb V, Das M.K., Mittra P, Ahmed A, Singh SS, Kaur P, Kumar M, Dash AP and Sharma YD (2009): Emergence of an Unusual Sulfadoxine-Pyrimethamine Resistance Pattern and a Novel K540N Mutation in Dihydropteroate Synthetase among Post-tsunami Plasmodi (if=5.99, ci=25) 6. Lumb V, Das M.K., Singh N, Dev V, Khan W, Sharma YD, (2009): Charactristic of genetic hitchhiking around Plasmodium falciparum dihydrofolate reductase (dhfr) gene associated with pyrimethamine resistance, in India. Antimicrob Agents Chemother; 53( (if=4.47, ci=14) 7. Das M.K, Lumb V , Mittra P. , Singh S.S. , Das A.P. and Sharma Y.D.(2010): High Chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from (if=5.31, ci=17) 8. Singh O.P., Dykes C.L., Das M.K., Pradhan S., Bhatt R.N., Agarwal O.P. and Adak T.(2010): Presence of two alternative kdr-like mutations, L1014F and novel mutation , V1010L, in the voltage Na+channel of Anopheles culicifacies from Orissa India. Mal (if=3.11, ci=33) 9. Das M K, Dhamodharan R, Hoti SL, Das AP (2011): Molecular differentiation of periodic and sub- periodic Wuchereria bancrofti and Brugia malayi by randomly amplified polymorphic DNA (RAPD) markers. World journal Microbiol Biotechnol;1525-30. (if=1.53, ci=1) 10. Tyagi R K, Das M K*, Singh S S, Sharma Y D, (2013): “Discordance in drug resistance associated mutation patterns in marker genes of Plasmodium falciparum and Plasmodium knowlesi during co- infections” J Antimicrob Chemother ; 68 (5):1081-8. *equal (if=5.31, ci=29)

310

HUSSAIN, SYED AINUL (b 1960), Scientist G, Wildlife Institute of India, Dehradun

Member of the NASI: No (YON 2016, Animal Sciences)

Dr. Syed Ainul Hussain is internationally acclaimed for his contributions to wildlife sciences. His cutting edge research on otters has led to enhanced understanding of their status, ecology and sociobiology. His work on reproductive success and population vulnerability of gharial has contributed to the understanding of the ecology and biology of this ‘Critically Endangered’ species. His pioneer work on environmental flow contributed significantly in decision making at apex level on water allocation for conservation. His work on seals and penguins in Antarctica provides the baseline for further research. His research on the last remaining population of the critically endangered Eld’s deer or Sangai is unmatched. Dr. Hussain’s research on the movement of breeding waterbirds with special reference to Black-necked cranes and Bar-headed geese has unfolded the mystery of movement pattern of migratory water birds and their ecology in the Tibetan plateau in the wake of increasing anthropogenic pressures and climate change. His scientific contributions to ecosystem level processes such as biomass productivity of wetlands and ecosystem services of the mangrove ecosystems and forested landscapes are highly appreciated. His work on endangered species, ecosystems and their link to biodiversity conservation has helped bridge the gap between ecology and conservation biology. Proposer: Prof. Mewa Singh, Seconder: Prof. K.S. Rangappa Ten Best Publications: 1. Kumar, A, Ghazi, M.G.U, Hussain, S.A., Bhatt D., Gupta, S.K. (2016): Mitochondrial and nuclear DNA based genetic assessment indicated distinct variation and low genetic exchange among the three subspecies of Swamp deer. Evolutionary Biology,44:31-42. (if=2.747) 2. Platt, R.P., Ogra. M.V., Badola, R., Hussain, S.A. (2016): Conservation-induced resettlement as a driver of land cover change in India: An object-based trend analysis. Applied Geography. 69 (2016) 75e86 (if=2.565) 3. Tuboi, C., Hussain, S.A. (2014): Factors affecting forage selection by the endangered Eld’s deer and hog deer in the floating meadows of Barak-Chindwin Basin of North-east India. Mammalian Biology. 81(1):53-60. (if=1.595) 4. Hoffmann, M., Hilton-Taylor, C., Angulo, A.,Hussain, S. A.,et al. (2010): The Impact of Conservation on the Status of the World’s Vertebrates. Science. 330: 1503-1509. (if=34.661, ci=688) 5. Hussain, S.A. (2009): Basking site and water depth selection by gharial (Gavialis gangeticus) in National Chambal Sanctuary and its implication for river conservation. Aquatic Conservation. 19(2): 127- 133. (if=34.661, ci=845) 6. Schipper, J., Chanson, J. S., Chiozza, F., Hussain, S. A.,et al. (2008): The Status of the World's Land and Marine Mammals: Diversity, Threat, and Knowledge. Science, 322: 225-230. (if=2.415, ci=24) 7. Anoop, K. R., Hussain, S.A. (2004): Factor affecting habitat selection by smooth coated otter Lutra perspicillata in Kerala, India. Journal of Zoology. 263 (4) 417-423. (if=1.819, ci=43) 8. Hussain, S.A. (1999): Reproductive success, hatchling survival and growth of a managed population of Ganges gharial. Biological Conservation. 87:261-268. (if=3.985, ci=36) 9. Hussain, S.A., Choudhury, B.C. (1997): Status and distribution of smooth-coated otter (Lutra perspicillata) in National Chambal Sanctuary. Biological Conservation. 80:199-206. (if=3.985, ci=40) 10. Hussain, S.A. (1996): Group size, group structure and breeding in smooth-coated otter (Lutra perspicillata), Geoffroy in National Chambal Sanctuary. Mammalia. 60(2): 289-297. (if=0.681, ci=19)

311

MISRA, ADITYA KUMAR (b 1957), Vice Chancellor, Maharashtra Animal and Fishery Sciences University, Futala Lake Road, Nagpur

Member of the NASI: No (YON 2016, Animal Sciences)

Prof. Misra’s pioneering research works on embryo biotechnology in buffalo lead to establishment of embryo transfer (ET) technology in this species that is so important for India and Asia. Consequently, he was invited and sponsored as lead speaker in several national/ international conferences in India and many other top buffalo rearing countries [Italy 2X, Brazil, China, Indonesia, Sri Lanka, Philippines etc.] and became global leader in this field. He produced first buffalo calves following freezing of embryos & non-surgical and surgical embryo transfers in Asia. His group demonstrated first successful vitrification of immature buffalo oocytes; and produced over thousand cattle and over 140 buffalo calves using ET Technology, including a record 11 calves following embryo transfer to 14 recipients (78.6% conception) that was widely acclaimed by media and the Prime Minister. He established OPU-IVF technology in buffalo and Sahiwal cows and was involved in production of first buffalo calf through OPU-IVF in India. The first ONBS project of India/Asia was also successfully implemented by his group at NDDB. He was actively involved in the superovulation of more than 3500 indigenous (Sahiwal, Gir, Kankrej, Red-Sindhi), crossbred and exotic (Holstein and Jersey) cows. Produced over 9700 viable embryos, cryopreserved over 5400 embryos and established over 1400 pregnancies using ET technology. For his outstanding research contribution he has been bestowed with three national awards viz. Rafi Ahmad Kidwai Award and Jawaharlal Nehru Award by the ICAR and Dr. P. Bhattacharya Memorial Award by the National Academy of Agricultural Sciences. Proposer: Dr. G. C. Mishra, Seconder: Dr. Mohan Wani Ten Best Publications: 1. Mishra, V., Misra, A.K. and Sharma, R (2008): A comparative study of parthenogenic activation and in vitro fertilization of bubaline oocytes, Anim. Reprod. Sci.103:249-259. (if=1.377, ci=16) 2. Shukla, MK and Misra, AK. (2007): Effect of bradykinin on Murrah buffalo (Bubalus bubalis) semen cryopreservation. Anim. Reprod. Sci. 97:175-179. (if=1.377, ci=92) 3. Mishra, V., Misra, A.K. and Sharma, R. (2007): Effect of ambient temperature on in-vitro fertilization of Bubaline oocyte. Anim. Reprod. Sci. 100:379-384. (if=1.377, ci=72) 4. Wani, N.A., Misra, A.K., Maurya, SN (2004): Maturation rates of vitrified-thawed immature buffalo (Bubalus bubalis) oocytes: effect of different types of cryoprotectants. Anim. Reprod. Sci. 84 : 327–335. (if=1.377, ci=63) 5. Wani, N.A., Maurya, S.N., Misra, A.K., Saxena, V.B. and Lakhchaura, B.D. (2004): Effect of cryoprotectants and their concentration on in vitro development of vitrified-warmed immature oocytes in (if=1.377, ci=63) 6. Pant, H.C., Sharma, R.K., Patel,S.H., Shukla, H.R., Mittal, A.K., Kasiraj, R., Misra, A.K., Prabhakar, J.H. (2003): Testicular development and its relationship to semen production in Murrah buffalo bulls. Theriogenology 60: 27-34. (if=2.056, ci=50) 7. Misra, A.K., Mutha Rao, M., Kasiraj, R., Ranga Reddy, N.S. and Pant, H.C. (1999): Factors affecting pregnancy rate following non-surgical embryo transfer in buffalo (Bubalus bubalis) - a retrospective study. Theriogenology, 52 (1): 1-10. (if=2.056, ci=22) 8. Misra, A.K., Kasiraj, R., Mutha Rao, M., Rangareddy, N.S., Jaiswal, R.S. and Pant, H.C. (1998): Rate of transport and development of preimplantation embryo in the superovulated buffalo (Bubalus bubalis). Theriogenology, 50(4):637-649. (if=2.056, ci=25) 9. Kasiraj, R., Misra, A.K., Mutha Rao, M., Jaiswal, R.S. and Rangareddi, N.S.(1993): Successful Culmination of Pregnancy and Live Birth Following the Transfer of Frozen-Thawed Buffalo Embryos. Theriogenology, 39: 1187 - 1192. (if=2.056, ci=18) 10. Misra, A.K., Joshi, B.V., Agrawala, P.L., Kasiraj, R., Sivaiah, S., Rangareddi, N.S. and Siddiqui, M.U. (1990): Multiple ovulation and embryo transfer in Indian buffalo (Bubalus bubalis). Theriogenology, 33(5):1131-1142. (if=2.056, ci=43).

312

RAISUDDIN, SHEIKH (b 1961), Professor, Jamia Hamdard (Hamdard University), New Delhi

Member of the NASI: Yes (YON 2016, Animal Sciences)

Prof. S. Raisuddin has significantly contributed to the field of toxicology by taking lead in newer areas of research and mentoring over 30 Ph.D. scholars. He has made significant contributions to three major areas: biomarkers of exposure and effects and their utility in monitoring and risk assessment of aquatic toxicants, molecular mechanisms of toxicity of endocrine disrupting chemicals (EDCs) and prevention of toxicity of anticancer drugs. His research on biomarkers of exposure to environmental toxicants using Indian freshwater fish models has been extensively cited (Sayeed et al., 2003; Pandey et al., 2003 cited 270 and 230 times, respectively). Using this approach it was shown that oxidative stress biomarkers could be used for monitoring the water quality of river Yamuna. A number of new biomarkers such as protein carbonyls were used for the first time in exposure monitoring (Parvez & Raisuddin, 2003). The other area of his research focuses on prevention of toxicity of anticancer drugs using herbal extracts which are used in Indian systems of medicine (Haque et al., 2001, 2003; Bhatia et al., 2006; Saba et al., 2013; Abdi et al., 2016). Research on EDCs has revealed modulatory effects of nutritional factors on their toxicity with special reference to male reproductive system (Rashid et al., 2009; Anjum et al., 2011; Khan et al., 2016). Recently, he has undertaken research to unravel the molecular interaction of EDCs (bisphenol A) and anticancer drugs (cyclophosphamide) with peroxisome proliferator-activated receptors and urothelium transmembrane proteins (uroplakins), respectively using transcriptomics (Abdi et al., 2016). Proposer: Prof. N.K. Ganguly, Seconder: Prof. S.E. Hasnain Ten Best Publications: 1. Fatima M, Ahmad I, Sayeed I, Athar M, Raisuddin S (2000): Pollutant-induced over-activation of phagocytes is concomitantly associated with peroxidative damage in fish tissues. Aquatic Toxicology 49 (4):243-250. (if=3.557, ci=108) 2. Sharma N, Trikha P, Athar M, Raisuddin S (2001): Inhibition of benzo[a]pyrene- and cyclophoshamide- induced mutagenicity by Cinnamomum cassia. Mutation Research, 480-481: 179-188. (if=2.881, ci=52) 3. Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S (2003): Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. International Immunopharmacology 3 (2): 257-265. (if=2.551, ci=134) 4. Sayeed I, Parvez S, Pandey S, Bin-Hafeez B, Haque R, Raisuddin S (2003): Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch. Ecotoxicology and Environmental Safety, 56 (2): 295 –301. (if=3.130, ci=270) 5. Pandey S, Parvez S, Sayeed I, Haque R, Bin-Hafeez B, Raisuddin S (2003): Biomarkers of oxidative stress: a comparative study of river Yamuna fish Wallago attu (Bl. & Schn.). Science of the Total Environment, 309 (1-3): 105-115. (if=3.976, ci=230) 6. Ali M, Parvez S, Pandey S, Atif F, Kaur M, Rehman H, Raisuddin S (2004): Fly ash leachate induces oxidative stress in freshwater fish Channa punctata (Bloch). Environmental International 30 (7): 933-938. (if=5.929, ci=38) 7. Bhatia K, Kaur M, Atif F, Ali M, Rehman H, Rahman S, Raisuddin S (2006): Aqueous extract of Trigonella foenum graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food and Chemical Toxicology 44 (10): (if=3.584, ci=48) 8. Pandey S, Parvez S, Ansari RA, Kaur M, Hayat F, Ahmad F, Raisuddin S (2008): Effects of exposure to multiple trace metals on biochemical, histological and ultrastructural features of gills of a freshwater fish, Channa punctata Bloch. Chemico-Biologi (if=2.618, ci=130) 9. Rashid H, Ahmad F, Rahman S, Ansari RA, Bhatia K, Kaur M, Islam F, Raisuddin S (2009): Iron deficiency augments bisphenol A-induced oxidative stress in rats. Toxicology 256 (1-2):7-12. (if=3.816, ci=22) 10. Anjum S, Rahman S, Kaur M, Ahmad F, Rashid H, Ansari RA, Raisuddin S (2011): Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Food and Chemical Toxicology 49 (11): 2849-2854. (if=3.584, ci=28)

313

SENGUPTA, PINAKI PRASAD (b 1964), Principal Scientist, ICAR-National Institute of Veterinary & Disease Informatics, Bangalore

Member of the NASI: No (YON 2016, Animal Sciences)

I. Development of molecular diagnosis system, recombinant antigen and monoclonal antibody based CI- ELISA, Ag-ELISA, host-parasite interaction in trypanosomosis in animals (Sengupta et al., 2010;2012; 2014; 2016, Rudramurthy et al., 2013; 2013; 2017, Ligi et al., 2015; 2016, Krishnamoorthy et al., 2016). II. First report of bovine neosporosis in cattle and its association with abortion in southern India (Sengupta et al. 2013). III. Development of COFEB diagnostic kit for detection of babesiosis in equines. This is first diagnostic kit for any parasitic disease in animals in India and first equine babesiosis kit in the world (Sengupta & Panisup, 2000). This kit was sold commercially after thorough field validation. IV. Development and launching of first animal disease forecasting system in the country- NADRES (national animal disease referral expert system) (Prabhudas et al., 2005). Monthly expected outbreak report of animal diseases generated through NADRES are sent to all state govt./ UTs sixty days in advance. V. Identification of a common sharing antigen for diagnosis of bovine tropical theileriosis that presents in both schizonat and piroplasmic stages in bovine and having tremendous diagnostic value (Sengupta et al., 1997a, 1997b). VI. Survey of equine strongyle helminthes in north, north-western India (Sengupta & Yadav, 1997, 1998, 2001, 2003) and also first time report of fauna of strongylid helminthes in Indian wild asses (Sengupta & Dey, 2009). VII. Exhaustive study on progression of mange in goats and its treatment (Sengupta et al. 1997; Sengupta & Basu 2007; Sengupta et al., 2008; Sengupta & Basu 2008). Proposer: Dr. Parimal Roy , Seconder: Dr. Sankar Kumar Ghosh Ten Best Publications: 1. Raghavendra, A.G., Gajendragad, M.R., Sengupta, P.P. et al. (2008): Seroepidemiology of peste des petits ruminants in sheep and goats of southern peninsular India. Scientific and Technical Review (OIE) 27(3):861 – 867. (if=1.52, ci=21) 2. Sengupta, P.P. et al. (2010): PCR-based diagnosis of surra-targeting VSG gene: Experimental studies in small laboratory rodents and buffalo. Veterinary Parasitology 171:22-31. (if=2.460, ci=20) 3. Sengupta, P.P.et al, (2012): Expressed truncated N-terminal variable surface glycoprotein (VSG) of Trypanosoma evansi in E. coli exhibits immuno-reactivity. Veterinary Parasitology 187(1-2):1-8. (if=2.460, ci=17) 4. Rudramurthy, G.R., Sengupta,P.P. et al. (2013): PCR based diagnosis of trypanosomiasis exploring invariant surface glycoprotein (ISG) 75 gene. Veterinary Parasitology 193: 47– 58. (if=2.460, ci=11) 5. Sengupta, P.P. et al. (2014): Sero- Diagnosis of surra exploiting recombinant VSG antigen based ELISA for Surveillance. Veterinary Parasitology 205:490-498. (if=2.460, ci=7) 6. Rudramurthy, G.R., Sengupta, P.P. et al. (2015): Development of an enzyme immunoassay using recombinant invariant surface glycoprotein (rISG) 75 for serodiagnosis of bovine trypanosomosis. Indian Journal of Experimental Biology 53: 7-15. (if=1.165, ci=6) 7. Ligi,M., Sengupta,P.P.et al.(2016): Flagellar antigen based CI-ELISA for sero-surveillance of surra. Veterinary Parasitology 219: 17-23. (if=2.460, ci=1) 8. Krishnamoorthy, P., Sengupta, P.P. et al. (2016): Cytokine gene expression and pathology in mice experimentally infected with different isolates of Trypanosoma evansi. Experimental Parasitology 170: 168-176. (if=1.623, ci= -) 9. Sengupta, P.P. et al. (2016): Development of ELISA exploring recombinant variable surface glycoprotein for diagnosis of surra in animals. Current Science 111(12): 2022 - 2027. (if=0.967, ci=1) 10. Rudramurthy,GR., Sengupta,P.P. et al.(2017): An inhibition enzyme immune assay exploring recombinant invariant surface glycoprotein….. for surveillance of surra in animals.Biologicals46C: 148- 152(DOI. org/10.1016/j.biologicals.2017.02.004). (if=1.690, ci=-)

314

SUBBIAH, POOPATHI (b 1962), Scientist-F, Vector Control Research Centre (ICMR), Pondicherry Member of the NASI: No (YON 2016, Animal Sciences)

It is a pleasure for me to propose Dr.S.Poopathi, a senior scientist and vector control specialist from Indian Council of Medical Research for fellowship in the National Academy of Sciences (India), Allahabad. He has worked on the area of control of mosquito vectors transmitting diseases. He has filed two Indian patents to his credit, Indian Patent No. 319 / Del / 2005 “Microbial fermentation process from bird feather for the production of bio-pesticides” and Indian Patent No. 358 / Del / 2006,“Lethal mosquito attractant and the preparation”, transferred to BCIL, New Delhi for commercialization. Another Indian Patent No. 1106 / Del/ 2008, “New bacterial culture medium for production of mosquitocidal bacilli using industrial wastes” registered in ICMR for commercialization. His findings on “Chicken feather waste” as source of bio-pesticide production in mosquito control and demonstration of de-hairing enzymes in culture supernatants of Bti deserves appreciations. Dr. S. Poopathi has isolated 31 new bacterial strains of Bacillus sphaericus, B.thuringiensis, B.cereus and Enterobactor cloaca from various sources. Identified and characterized surface layer protein (SLP) from B.cereus (VCRC-B540) as potent mosquito larvicidal toxin as public health tool for control of vector borne diseases. Dr.Poopathi has published more than 90 research papers (all first and corresponding author) and recipient of several awards like, ABJ. Abdul Kalam Award, ICMR-Award, Technology Achievement Award, Sushruta Best Scientist Award, Recognition Award etc. Member in professional bodies, Executive editor and Editorial Board member. I strongly recommend Dr.S.Poopathi for the Fellowship of NASI. Proposer: Prof. Umesh Chandra Srivastava, Seconder:Dr.Tridibes Adak Ten Best Publications: 1. Poopathi, S, Nielsen-LeRoux C, and Charles, J.-F (2002): Alternative methods for preservation of mosquito larvae to study binding mechanism of Bacillus sphaericus toxin. J. Invertebrate Pathology. 79: 132 – 134. (I.F: 2.60) 2. Poopathi, S, and S. Abidha (2011): Coffee husk waste for fermentation production of mosquitocidal bacteria. Journal of Economic Entomology 104 (6) 1816-1823. (I.F: 1.60). 3. Poopathi, S, and B. Archana (2012): Wastewater Management from Slaughterhouse -A New Approach to Control Mosquitoes. Water Air & Soil Pollution.223: 3263-3270. (I.F: 1.68) 4. Poopathi, S, and B. Archana (2013): Management of waste product from watermelon for culture and production of mosquitocidal toxins (bio-pesticide). International Journal of Environment and Waste Management 12 (4): 442-452. (I.F: 1.25). 5. Poopathi, S., C. Mani, V. Vignesh, V. Lakshmi Praba & K.Thirugnanasambantham (2013): Genotypic diversity among newly isolated mosquitocidal bacteria (Bacillus sphaericus, B.thuringiensis and B. cereus). Applied Biochemistry and Biotechnology. 171: 2233-2246. (I.F: 1.68). 6. Poopathi, S, C. Mani, K. Thirugnanasambantham, Niyaz Ahmad Ahangar, K. Balagangadharan (2014): Identification and characterization of a novel marine Bacillus cereus for mosquito control. Parasitology Research. 113 (1) 323-332. (I.F: 2.85). 7. Poopathi, S, Thirugnanasambantham, K, Mani, C, Athisaya Mary, K, Ann Mary B and Balagangadharan K (2014): Hexamerin a novel protein associated with Bacillus sphaericus resistance in Culex quinquefasciatus. Applied Biochemistry and Biotechnology. 172: 2299-2307. (I.F: 1.68). 8. Poopathi, S, Thirugnanasambantham, K, Mani, C, Ragul K, Sundarapandian SM, (2014): Isolation of novel mosquitocidal bacteria (Bacillus thuringiensis, B.sphaericus and B.cereus) from excreta of arid birds. Indian Journal of Experimental Biology, 52: 739-747. (I.F.:1.20). 9. Poopathi, S, Mani, C, Thirugnanasambantham, K, Sundarapandian, SM, Ann Mary, B and Jayaprakash, D (2015):Isolation of novel mosquitocidal bacteria from the gut content of marine fishes. Environmental Science and Pollution Research, (In Press). (I.F: 2.80). 10. Poopathi, S, De Britto R.L.J, Lakshmi Praba L, Mani C, Praveen M (2015): Synthesis of silver nanoparticles from Azadirachta indica – a most effective methods for mosquito control. Environmental Science and Pollution Research 22: 2956-2963. (IF: 2.80).

315

TRIPATHI, BHUPENDRA NATH (b 1962), Director, ICAR-National research Centre on Equines, Hisar

Member of the NASI: No (YON 2016, Animal Sciences)

1. Dr Tripathi has made outstanding and fundamental contributions on paratuberculosis of animals with regard to host- interaction, mechanism of Map induced cellular pathology and development of highly specific serological (ELISA) and molecular diagnostics against M.avium paratuberculosis (Map) (Duraisamy et al., 2013; Rajukumar et a., 2001, Tripathi et al., 2005, Sonawane et al., 2013, Sivakumar et., 2013). 2. The nominee has discovered for the first time that Salmonella pathogenicity island 2 (SPI-2) is required by serotype Dublin for the induction of both systemic and enteric salmonellosis in calves (Bispham et. al., 2001). 3. His recent work on development of mouse model (a global first) for understanding equine influenza pathogenesis has opened a gateway for functional genomics and proteomics besides providing an efficient system to adjudge the protective efficacy of vaccine candidates (Puvulraj et al., 2015). His studies based on analysis of Genome vide codon usage patterns of 92 equine influenza viruses (H3N8 and H7N7), proposed an explanation for extinction of H7N7 viruses and improved understanding of factors involved in viral adaptation, evolution and their fitness towards their host (Naveen kumar et al., 2016). Generation of recombinant equine influenza virus and equine herpes virus 1 through reverse genetics approach and bacterial artificial chromosome technology has extreme potential for development of attenuated vaccines. 4. He is playing significant role in animal microbial conservation in the country with current reposition of 1025 bacteria, 170 veterinary viruses, 511 recombinant clones, genomic DNA, 68 bacteriophages, 270 rumen microbes and 468 dairy microbes. Proposer: Prof. M.L. Madan, Seconder: Prof. Parimal Roy Ten Best Publications: 1. Bispham, J., Tripathi, B.N., Watson, P. R and Wallis, T. S. (2001): Salmonella pathogenicity island-2 influences both systemic salmonellosis and Salmonella induced enteritis in calves. Infection and Immunity, 69(1):367-377.) (if=3.603, ci=113). 2. Kumar,P. Tripathi, B.N, Sharma, A.K., Kumar, R., Sreenivas, B.P. Singh, R.P., Dhar, P., Bandyopadhyay SK. (2004): Pathological and immunohistochemical study of experimental peste des petits ruminants (PPR) virus infection of goats. Journal of Veteri (if=2.369, ci=53) 3. Sivakumar P., Tripathi. B.N. and Singh, N.(2005): Detection of Mycobacterium avium subsp.paratuberculosis from intestinal and lymph node tissues of water buffaloes by PCR and bacterial culture. Veterinary Microbiology, 108: 263-270. (if=(if=2.564, ci=64) 4. Tripathi, B.N., Sivakumar, P., Paliwal , O.P., Singh, N. (2006): Comparison of tissue PCR, bacterial culture, johnin and serological test in the diagnosis of naturally Zoonosis and Public Health occurring paratuberculosis in goats. Veterinary Micr (if=2.564, ci=36) 5. Munjal, S.K., Tripathi, B.N., Paliwal, O.P. and M. Homuth. (2006): Application of different methods for the diagnosis of experimental paratuberculsosis in goats. Zoonoses and Public Health, 54: 140-146. (if= 2.574, ci=11) 6. Sivakumar P., Tripathi, B.N., Nem Singh. (2013): Mechanisms of Mycobacterium avium subsp. paratuberculosis induced apoptosis and necrosis in bovine macrophages. Veterinary Microbiology. 165: 392-401. (if=2.564, ci=7) 7. Pavulraj, S., Bera, B.C., Alok Joshi, Anand Taruna, Virmani Meenakshi, Vaid, R.K., Shanmugasundaram, K., Singh Rajendra, Singh, R.K., Tripathi, B.N. and Virmani Nitin. (2015): Pathology of equine influenza virus (H3N8) belonging to Clade 2 of Florid (if=4.411, ci=Recently published) 8. Naveen Kumar, Bidhan Chandra Bera, Benjamin D. Greenbaum, Sandeep Bhatia, Richa Sood, Pavulraj Selvaraj, Taruna Anand, Bhupendra Nath Tripathi (2016): Revelation of Influencing Factors in Overall Codon Usage Bias of Equine Influenza Viruses. PLOS One (if=4.411, ci=Recently published) 9. Kumar N,Barua S, Riyesh T, Singh SV, Sharma DK, Sharma S and Tripathi BN. (2016): Complexities in isolation and purification of multiple viruses from mixed viral infection: viral interference, persistence and exclusion, PLOS One, 11(5)e:0156110. (if=4.411, ci=Recently published) 10. Kumar N, Barua S, Riyesh T and Tripathi BN. (2017): Advances in peste des petits ruminants vaccine, Veterinary Microbiology, January 2017 DOI: 10.1016/j.vetmic.2017.01.010 (if=2.564, ci=Recently published)

316

TRIVEDI, RITU (b 1971), Senior Scientist, CSIR-Central Drug Research Institute, Lucknow

Member of the NASI: No (YON 2016, Animal Sciences)

Major scientific contributions of Dr. Ritu Trivedi are in the area of Metabolic Bone Disorders specifically post-menopausal osteoporosis. She has identified several molecules from natural resource (Trivedi et al., 2008, 2009; Kumar et al., 2010; Gautam et al., 2012; Khedgikar et al., 2012; Khedgikar et al., 2012; Gupta et al., 2013; Kushwaha et al., 2015; Kushwaha et al., 2016) or synthesized chemically (Sashidhar et al., 2012; Sashidhara et al., 2013) for improvement of bone health. Out of several molecules, 99/373 (CDRI code) showed promise as an anti-osteoporotic agent and is being prepared for clinical trials. She has standardized fraction of Dalbergia sissoo as an osteogenic agent (Khedgikar et al., 2012) which has led to translational benefits as a rapid fracture healing agent as well as valuable in primary osteoporosis. The standardized fraction can be taken orally and is cost effective since it is made from the renewable part of the plant. The Technology has been transferred to Pharmanza Pvt. Ltd. in April 2015. Clinical trial (CTRI/2015/06/005850) on accelerated fracture healing by Dalzbone has been started and drug will be formally available in market soon. In additional to translational work, Dr. Trivedi has established involvement of miR874-5p in bone formation and shown that this miRNA exerts skeletal anabolic effects epigenetically during weaning by suppressing Hdac1 (Khedgikar et al., 2016). Dr. Trivedi has also evaluated effectiveness of flavonoid-rich transgenic plants for improving bone health in animals (Pandey et al., 2014; Pandey et al., 2015; Chaudhary et al., 2016). Proposer: Dr , Seconder: Dr.V.P Kamboj Ten Best Publications: 1. Adhikary. S, Choudhary. D, Ahmad. N, Kumar. S, Dev. K, Mittapelly. N, Pandey. G, Mishra. P.R, Maurya. R, Trivedi.R. (2017): Dried and free flowing granules of Spinacia oleracea accelerate bone regeneration and alleviate post-menopausal osteopo (if=3.2) 2. Gautam J, Khedgikar V, Kushwaha P, Choudhary D, Nagar GK, Dev K, Dixit P, Maurya R, Trivedi R (2017): Formononetin, an isoflavone, activates AMPK/β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice against high fat diet induced o (if=3.34) 3. Ahmad N , Banala VT, Kushwaha P, Karvande A, Sharma S, Tripathi AK, Verma A, Trivedi R Mishra PR (2016):Quercetin-loaded solid lipid nanoparticles improve osteoprotective activity in an ovariectomized rat model: a preventive strategy for post-meno (if=3.2, ci=1) 4. Kushwaha P, Khedgikar V, Ahmad N, Karvande A, Gautam J, Kumar P, Maurya R, Trivedi R (2016): A neoflavonoid dalsissooal isolated from heartwood of Dalbergia sissoo Roxb. has bone forming effects in mice model for osteoporosis. European Journal of (if=2.7, ci=1) 5. Sashidhara KV, Singh LR, Choudhary D, Arun A, Gupta S, Adhikary S, Palnati GR, Konwar R, Trivedi R (2016): Design, synthesis and in vitro evaluation of coumarin–imidazo [1, 2-a] pyridine derivatives against cancer induced osteoporosis. RSC Adv. 6 (if=3.2, ci=2) 6. Gautam J, Khedgikar V, Choudhary D, Kushwaha P, Dixit P, Singh D, Maurya R, Trivedi R (2016): An isoflavone cladrin prevents high fat diet induced bone loss and inhibits the expression of adipogenicgene regulators in 3T3-L1 adipocyte. J Phar Phar (if=2.6, ci=1) 7. Choudhary D, Pandey A, Adhikary S, Ahmad N, Bhatia C, Bhambhani S, Trivedi PK, Trivedi R (2016): Genetically engineered flavonol enriched tomato fruit modulates chondrogenesis to increase bone length in growing animals. Scientific Reports 6:21668 (if=5.2, ci=5) 8. Verma A, Sharma S, Gupta PK, Singh A, Teja BV, Dwivedi P, Gupta GK, Trivedi R, Mishra PR (2016): Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of in (if=6.03, ci=10) 9. Kushwaha P, Khedgikar V, Sharma D, Yuen T, Gautam J, Ahmad N, Karvande A, Mishra PR, Trivedi PK, Sun Li, Bhadada SK, Zaidi M, Trivedi R (2016): MicroRNA-874-3p exerts skeletal anabolic effects epigenetically during weaning by suppressing Hdac1. Jo (if=4.5, ci=6) 10. Pandey G, Mittapelly N, Pant A, Sharma S, Singh P, Banala VT, Trivedi R, Shukla PK, Mishra PR (2016): Dual functioning microspheres embedded cross linked gelatin cryogels for therapeutic intervention in osteomyelitis and associated bone loss Europe (if=3.7, ci=2)

317

JADHAO, ARUN GOVINDRAOJI (b 1960), Professor, Department of Zoology, RTM Nagpur University, Nagpur

Member of the NASI: No (YON 2015, Animal Sciences)

Prof. Jadhao did M.Sc. and Ph.D. in Zoology from Nagpur University, Nagpur. Subsequently, he received prestigious fellowship of Alexander von Humboldt (AvH) Foundation, Germany to pursue postdoctoral training in Germany (1994-96) and further worked at different institutes in Germany. He made significant contributions in the area of neuroanatomy and neuroendocrinology. The nominee made a novel finding which shows the anatomically distinct two brain types in the same gender of the fish species and this has been shown for first time in any vertebrate animals demonstrating the inter-sexual and intra-sexual dimorphisms within the males and within females brain, which predominantly seen in the preoptic and tuberal region. Probably such dimorphisms may responsible for the different reproductive behaviors within the same gender. Further, he made a significant contribution in identifying neuronal descending pathways in the central nervous system (CNS) and demonstrated different neuronal cell populations of the brain that projecting to the spinal cord extending up to 25th segment and also shows regeneration capacity in fish. He also identified the gender differences in the expression of galanin and calcium binding protein in the fish preoptic area which controls the hormonal regulation by the pituitary. He identified several novel peptidergic, aminergic, nitrinergic and calcium binding proteins (CaBPs) containing neurons, some co- expressing these substances, and participating in hypophysial regulation using immunocytochemical and fluorescence techniques. For the first time his group has reported the presence of GnIH in the olfactory system and pituitary gland of fish and frog, confirming its role in the hormonal regulation. Proposer: Prof. P. D. Prasada Rao , Seconder: Dr. Subeer Mujumdar Ten Best Publications: 1. Jadhao, A. G., Malz, C. R. (2004): Nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase activity in the brain of a cichlid fish, with remarkable findings in the entopeduncular nucleus: A histochemical study. J. Chem. Neuroanat. 27: 75-86 (if=2.5, ci=12) 2. Jadhao, A. G., Malz, C. R. (2003): Localization of NOS-I isoform in the diencephalon and pituitary gland of the catfish, Synodontis multipunctatus: An Immunocytochemical Study. Gen.Comp. Endocrinol. 132(2): 278-283. (if=3.28, ci=15) 3. Jadhao, A. G., D´Aniello, B., Malz, C. R., Pinelli, C., Meyer, D. L. (2001): Intra-sexual and inter-sexual dimorphisms of the red salmon prosencephalon. Cell Tissue Res. 304(1): 121-140. (if=3.33, ci=13) 4. Jadhao, A. G., Pinelli C. (2001): Galanin-like Immunoreactivity in the brain and pituitary gland of the ‘four-eyed’ fish, Anableps anableps. Cell Tissue Res. 306(2):309-318. (if=3.33, ci=20) 5. Jadhao, A. G., Meyer D. L. (2000): Sexually dimorphic distribution of galanin in the preoptic area of red salmon, Oncorhynchus nerka. Cell Tissue Res. 302(2):199-203. (if=3.33, ci=23) 6. D´Aniello, B., Pinelli, C. Jadhao, A. G., Rastogi, R. K., Meyer, D. L. (1999): Comparative analysis of FMRFamide-like immunoreactivity in the brain of the caiman (Caiman crocodilus) and the turtle (Trachemys scripta elegans). Cell Tissue Res. 298(3): (if=3.33, ci=19) 7. Meyer, D. L., Jadhao, A. G., Kicliter, E. (1996): Soybean agglutinin binding by primary olfactory and primary accessory olfactory projections in different frogs. Brain Res. 722:222-226. (if=2.82, ci=19) 8. Prasada Rao, P. D., Jadhao, A. G., Sharma, S. C. (1993): Topographic organization of descending projection neurons to the spinal cord of the goldfish, Carassius auratus. Brain Res. 620:211-220. (if=2.82, ci=21) 9. Sharma, S. C., Jadhao, A. G., Prasada Rao, P. D. (1993): Regenration of supraspinal projection neurons in the adult goldfish. Brain Res. 620:221-228 (if=2.82, ci=61) 10. Prasada Rao, P. D., Jadhao, A. G., Sharma, S.C. (1987): Descending projection neurons to the spinal cord of the goldfish, Carassius auratus. J. Comp. Neurol. 265:96-108. (if=3.7, ci=97)

318

KAMARAJU, RAGHAVENDRA (b 1957) Scientist F, National Institute of Malaria Research (ICMR), Delhi

Member of the NASI: Yes (YON 2015, Animal Sciences)

The nominee Dr. Raghavendra is an established investigator in the area of Entomology & Malariology. He has made significant contributions to the field of vector control, insecticide resistance and its management both are of relevance to the public health programme. His Ph.D. work gave for the first time evidence for the biochemical mechanisms underlying insecticide resistance in major malaria vectors. His later work demonstrated differential responses to different classes of insecticides among the sympatric An. culicifacies sibling species, and kinetics of development of resistance in field which led to suggesting specific indoor residual spray strategy for malaria vector control in India. His work on pyrrole class of insecticide acclaimed by World Health Organization has paved way for multi-country field evaluation studies and innovative combination nets with insecticides/synergists. A WHO research project recently carried out by him in Chhattisgarh, India (2012-16) showed impact of LLIN intervention alone with >80% coverage for managing the disease. A prototype bottle assay for detecting insecticide resistance in disease vectors using indigenous material is under multi-location validation. His recent work on in-silico approaches is providing leads for new strategies for insecticide resistance management. He is associated with WHO, GoI, ICMR on many decisions making committees and working groups on vector control and policy. His laboratory work on vector control methods using bio-pesticides has led to co-patenting of a plant extract as promising larvicide. He guided more than 20 PhD students and published 106 papers in peer-reviewed international and national journals and 12 articles as book chapters. Proposer : Dr. Sarala Karumuri Subbarao, Seconder : Prof. Kambadur Muralidhar Ten Best Publications: 1. Raghavendra K, Subbarao S K, Vasantha K, Pillai M K K, Sharma V P,(1992): Differential selection of malathion resistance in Anopheles culicifacies A and B (Diptera: Culicidae) in Haryana state. India. J Med Entomol, 29:183-187. IF=1.712, CI=26 2. Raghavendra K et al., (1998): Biochemical mechanisms of malathion-resistance in Indian Anopheles culicifacies (Diptera: Culicidae) sibling species A, B and C: Microplate assays and synergistic studies. Ann Ent Soc Amer, 91(5): 834-839. IF=1.190 CI=14 3. Raghavendra K et al., (2009): Multiplex PCR assay and phylogenetic analysis of sequences derived from D2 domain of 28S rDNA distinguished members of the Anopheles culicifacies complex into two groups, A/D and B/C/E. Infection, Genetics and Evolution, 9: 271–277. IF=2.591 CI=16 4. Raghavendra K, Singh S P, Subbarao S K, Dash A P, (2009): Laboratory studies on mosquito larvicidal efficacy of aqueous and hexane extracts of dried fruit of Solanum nigrum Linn. (Family: Solanaceae). Indian J Med Res, 130: 74-77. IF=1.446 CI=31 5. Raghavendra K et al.(2010): Persistence of DDT, malathion and deltamethrin resistance in Anopheles culicifacies after their sequential withdrawal from indoor residual spraying in Surat district Indian J Med Res 132: 260-264. IF=1.446 CI=22 6. Raghavendra K, Barik T K, Sharma P, Bhatt R M, Srivastava H C, Sreehari U, Dash A P,(2011): Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors. Malar J 10:16. IF=3.079 CI=43 7. Raghavendra K, Barik T K, Reddy B P N, Sharma P, Dash A P, (2011): Malaria vector control: from past to future. Parasitol Res 108:757–779. IF=2.027 CI=143 8. Barik TK, Raghavendra K*, Goswami A, (2012):. Silica nanoparticle: a potential new insecticide for mosquito vector control. Parasitol Res 111 (3): 1075-1083. IF = 2.027 CI=34 9. Bhatt RM, Sharma SN, Uragayala S, Dash AP, Raghavendra K, (2012): Effectiveness and durability of Interceptor® long-lasting insecticidal nets in a malaria endemic area of central India. Malar J 11: 189. IF=3.079 CI=26 10. Chourasia MK, Kamaraju R et al (2017): Impact of long-lasting insecticidal nets on prevalence of subclinical malaria among children in the presence of pyrethroid resistance in Anopheles culicifacies in Central India. International Journal of Infectious diseases 57:123-129. IF=2.229

319

KAR CHOWDHURI, DEBAPRATIM (b 1960) Chief Scientist & Professor, AcSIR; CSIR-Indian Institute of Toxicology Research, Lucknow

Member of the NASI: No (YON 2015, Animal Sciences)

The nominee has made significant contributions in the areas “stress biology and genotoxic stress”. His work received first-rate citations (65-pub;>1600 citations; Nature group journals) and award of prestigious international collaborative project (Major:UK-IERI; British Council). He developed and validated Drosophila model transgenic for stress genes for assessing chemicals-induced cellular toxicity for the first time; application in environmental monitoring studies; nanomaterials-safety, environmental chemical detection in different matrices and hsp70 expression as the first-tier bio-indicator of cellular adversity and as a redox-buffer and elucidation of the underlying mechanism (Environ.-Hlth.-Perspect,2003,111; BBA, 2005, 1725, 81; BBA, 2007, 1770, 1382; Ecotoxicology-&-Environmental-Safety,(Highlighted-article), 2009, 72, 1652; Toxicol. -Appl. -Pharmacol., 2009, 235, 226; Life-Sci., 2010, 86, 377; BBA, 2013, 1830,2256; Age,2014, 25, 1139;Free-Radical-Biology-&-Medicine,2015, PMID- 25746179,e-pub). Global gene expression profiling studies revealed that beside hsp70, other stress associated genes play role in better stress adaptability displayed by exposed organism. Recently, a mutation in methusalah gene (Class-II-GPCR) was shown for the first time to confer significant rescuing effect on dopaminergic neurons in chemical-induced Parkinson disease model of Drosophila and elucidation of underlying mechanism. Subsequently, metabolome profiling studies showed relevance to human as part of GPCR based drug targeting and parallel findings in human PD patients (Chemosphere, 2011, 82, 370; Neurobiology-of-Aging, 2014, 35, 2419, e1-16; PLoS-One,2014, 9(6),e98886;Molecular- Neurobiology,2015,PMID-25428622,e-pub). In genotoxic stress area, methods for the detection of single- strand-break, double-strand-break and oxidative DNA damage were developed and validated. He was the first to demonstrate (global gene profiling, genetic, miRNA profiling) that complex mechanism of DNA damage in Cr(VI)-exposed organism follows perturbation of non-homologous-end-joining DSB-repair. He also demonstrated that perturbed DNA repair in chemical-(DDVP)-exposed organism is due to faulty pre- and post-replication repair pathways along with alkylating and oxidative DNA damage (Environ. Mol. Mutagenesis,2005,46,189;Environ.-Mol.-Mutagenesis,2008,49,206;Mutation-Res,2011,722,44;Mutation- Res,2011,726,222;Mutation-Res-FMMM,2014,747–748,28;Mutation-Res,2014,766,35;J Hazardous Materials,2015,283,558) Proposer : Prof. Debi P. Sarkar, Seconder : Prof. Prahlad C. Ghosh Ten Best Publications : 1. Pandey A, Khatoon R, Saini S, Vimal D, Patel DK, Narayan G, Chowdhuri DK, (2015) : Efficacy of methuselah gene mutation towards tolerance against dichlorvos exposure to Drosophila melanogaster, Free Radical Biology and Medicine doi: 10.1016/ j.freeradbiomed.2015.02.025 (In Press). IF=5.78 2. Shukla AK, Pragya P, Chaouhan HS, Patel DK, Abdin MZ, Chowdhuri DK, (2014): A mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes, Neurobiology of Aging 35 (10), 2419. e1-2419. e16. IF=6.16, CI=4 3. Mishra M, Sharma A, Shukla AK, Pragya P, Murthy RC, de Pomerai, Chowdhuri DK, (2013): Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 747, 28-39. IF=4.44, CI=10 4. Pandey A, Chandra S, Chauhan LKS, Narayan G, Chowdhuri DK, (2013) : Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster, Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (1), 2256-2266. IF= 5.00, CI=11 5. Sharma A, Mishra M, Shukla AK, Kar Chowdhuri D. (2011) : Validation and application of Drosophila melanogaster as an in vivo model for the detection of double strand breaks by neutral Comet assay. Mutation Research, 721: 142-6 IF= 2.94, CI=11 6. Gupta SC, Sharma A, Mishra M, Mishra RK, Kar Chowdhuri D. (2010): Heat shock proteins in toxicology: How close and how far? (Mini Review), Life Sciences, 86: 377-84 IF= 2.45, CI=133 7. Singh MP, Reddy MM, Mathur N, Saxena DK, Chowdhuri Kar D. (2009): Induction of hsp70, hsp60, hsp83, and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation. Toxicology and Applied Pharmacology, 235: 226-43. (Among Top 25 hot articles of the Journal Sr. No. 18). IF= 3.99, CI=54 8. Siddique HR, Sharma A, Gupta SC, Murthy RC, Dhawan A, Saxena DK and Kar Chowdhuri D. (2008) : DNA damage induced by industrial solid waste leachates in Drosophila melanogaster: A mechanistic approach. Environmental & Molecular Mutagenesis, 49: 206-16 IF= 3.49 CI=18 9. Gupta SC, Siddique HR, Mathur N, Vishwaskarma AL, Mishra RK, Saxena DK and Kar Chowdhuri D. (2007): Induction of hsp70, alterations in oxidative stress and apoptosis against dichlovos exposure in transgenic Drosophila melanogaster: modulation by reactive oxygen species. Biochemica et Biophysica Acta (BBA), 1770): 1382-94 IF= 3.85, CI=37 10. Mukhopadhyay I, Saxena DK and Kar Chowdhuri D. (2003): Hazardous effect of effluent from chrome plating industry: 70kDa heat shock protein expression as a marker of cellular damage in transgenic Drosophila melanogaster (hsp70-lacZ). Environmental Health Perspectives, 111: 1926-32 [Among the top 10 articles (Sr. No. 7) in stress biology domain] IF= 7.02, CI=38

320

MATHUR, PREMENDU PRAKASH (b 1955), Vice-Chancellor, KIIT University, Bhubaneswar and Professor, School of Life Sciences, Pondicherry University, Pondicherry (on leave)

Member of the NASI: No (YON 2015, Animal Sciences)

The nominee has contributed significantly in the field of male reproduction and reproductive toxicity. He developed highly specific radioimmunoassay for clusterin and purified clusterin from ram sera, which gave new direction to clusterin research. He demonstrated that environmental contaminants at very low doses adversely affect male reproduction and proposed a mechanism of action based on generation of ROS and the involvement of mitochondrial- and Fas-FasL-dependent cell death pathways. He demonstrated that Bisphenol A impairs insulin signaling and glucose transport in rat testis thus leading to impaired testicular functions. He has shown that Adjudin, a novel , causes transient induction of oxidative stress accompanying restructuring of adherens junctions in testis and Interleukin-1 alpha is a novel regulator of blood-testis barrier. Using bioinformatics approach he proposed structures of glucose transporters, GLUT-2, GLUT-8 and gap junction protein, connexin 26 for the first time and demonstrated that Bisphenol A interacts with them thereby inhibiting glucose uptake in testis. These studies provided new insights into the mechanism of action of some of the environmental contaminants. Dr. Mathur has significantly contributed to the development of Bioinformatics teaching and research in India. He has led to the development of many open access databases. He is editorial board member of six and reviewer of over 100 national and international journals. He is Fellow of National Academy of Medical Sciences (India) and recipient of Asutosh Mookerjee Memorial Award. Elected as General Secretary (Scientific Activities), Indian Science Congress Association and Vice-President, Asian Association of Andrology, Shanghai. Proposer: Prof. U.C. Srivastava, Seconder: Prof. G.K. Srivastava Ten Best Publications: 1. J. Pranitha, Manivel Panneerselvam and P.P. Mathur.(2016): Effect of Environmental contaminants on spermatogenesis. SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 59: 126-140, (if=6.265, ci=0 (new)) 2. S. Cynthia D’Cruz, R. Jubendradass, M. Jayakanthan, S.J. Amala Rani and P.P. Mathur (2012): Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: an in vivo and in silico study. FOOD CHE (if=3.584, ci=35) 3. B. Saradha, S. Vaithinathan and P. P. Mathur (2009): Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria-dependent pathways. TOXICOLOGY 255: 131-139 (if=3.817, ci=57) 4. V. Bindhumol, K.C. Chitra and P.P. Mathur (2003): Bisphenol A induces reactive oxygen species generation in the liver of male rats, TOXICOLOGY 188: 117-124. (if=3.817, ci=178) 5. K.C. Chitra, C. Latchoumycandane and P.P. Mathur (2003): Induction of oxidative stress by bisphenol A in the epididymal sperm of rats, TOXICOLOGY 185:119-127 (if=3.817, ci=182) 6. C. Latchoumycandane, K.C. Chitra and P.P. Mathur (2003): 2.3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress in the epididymis and epididymal sperm of adult rats. ARCH. TOXICOL. 77: 280-284 (if=5.98, ci=67) 7. C. Latchoumycandane and P.P. Mathur (2002): Induction of oxidative stress in testis of rat after short- term exposure to organochlorine pesticide methoxychlor. ARCH. TOXICOL. 76: 692-698. (if=5.98, ci=48) 8. C. Latchoumycandane and P.P. Mathur (2002): Effect of methoxychlor on the antioxidant system in mitochondria and microsome-rich fractions of rat testis. TOXICOLOGY 176: 67-75 (if=3.817, ci=44) 9. C. Latchoumycandane, K.C. Chitra and P.P. Mathur (2002): The effect of 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin on the antioxidant system in mitochondrial and microsomal fractions of rat testis. TOXICOLOGY 171: 127-135. Impact Factor: 3.81 (if=3.817, ci=55) 10. K.C. Chitra, C. Latchoumycandane and P.P. Mathur (2002): Effect of nonylphenol on the antioxidant system in epididymal sperm of rats. ARCH. TOXICOL. 76: 545-551. (if=5.078, ci=65)

321

PRAKASH, SOAM (b 1956) Professor, Department of Zoology, Dayalbagh Educational Institute, Agra

Member of the NASI: Yes (YON 2015, Animal Sciences)

I am acquainted with Prof. Soam Prakash, FAZ ,FNESA contributions in the area of Nano Parasitology (Soni and Prakash,2011,212,2013,214,201s) and Public health/vector control technology last 20 years and would happy to propose him for the fellowship of the academy for the significant contribution in the country in Parasitology and Nanotechnology described below: 1.0ne of the first expert to utilize, synthesize silver and gold nano particles for Malaria, Filariasis Dengue, Chickengunia control. (2011,2012,2013,204,2015- onwards publications). 2.0ne of the first Indian author to initiate Consciousness research in animals by establishing a Quantum biology laboratory to trace evolutionary aspect of consciousness, providing outstanding support to create center of excellence in formulating consciousness and Quantum­ Nano center at Dayalbagh Educational Institute in 2111 and Children Science centre in 1994. 3.Has published more than 100 international publications, Guided 8 pH.Ds in diversified fields libe vector control, biotechnology, public health and successfully completed more than 10 major projects (DST,AICTE,UGC) etc. in last 20 years and has been awarded fellowship from Academy of Zoology and Fellow of national Environmental Science Academy in 1984 & 2006. 4. Chaired international conferences is reviewing at least 30 international journals of repute and is also been guest Group leader, Editorial list for journals of repute on special issues(4) and has been nominated as Editor for many journals of interdisciplinary research (Cell communication). He has worked in, lectured and visited various labs Viz, Cold Springer Harbor labs (USA) and has worked in laboratories like "AIfa Biogene, New Jersey", Research hospital at Minneola, USA (2000) and delivered invited lectures in the areas of diversified topics. (1984,2000,2012,2014) Proposer : Late Prof. V.P. Sharma, Seconder : Prof. Anand Mohan Ten Best Publications : 1. Soni,N. and Prakash, S. (2012): Efficacy of fungus mediated silver and gold nanoparticles against Aedes aegypti larvae. Parasitology research. Volume 110, Issue 1, pp 175-184. IF=2.327 CI=41 2. Soni,N. and Prakash, S. (2012): Fungal-mediated nano silver: an effective adulticide against mosquito. Parasitology Research. Volume 111, Issue 5, pp 2091-2098. IF=2.327 CI=11 3. Prakash, S., Singh, G., Soni, N.,Sharma., S. (2010): Pathogenicity of Fusarium oxysporum against .I the larvae of Culex quinquefasciatus (Say) and Anopheles stephensi (Liston) in laboratory. Parasitology Research. Volume 107, Issue 3, pp 651-655. IF=2.327 CI=17 4. Verma., P and Prakash., S. (2010):Efficacy of Chrysosporium tropicum metabolite against mixed population of adult mosquito (Culex quinquefasciatus, Anopheles stephensii, and Aedes aegypti) after purification with flash chromatography. Parasitology Researchl07(1):163-6. IF=2.327 CI=13 5. Soni., N and Prakash., S (2010): Effect of Chrysosporium keratinophilum metabolites against Culex quinquefasciatus after chromatographic purification. Parasitology Research.Volume 107, Issue 6, pp 1329-1336. IF=2.327 CI=13 6. Singh., G and Prakash., S (2009): Efficacy of Bacillus sphaericus against larvae of malaria and filarial vectors: an analysis of early resistance detection. Parasitology Research.Volume 104, Issue 4, pp 763- 766. IF=2.327 CI=17 7. Mohanty., S.S and Prakash., S (2008): Laboratory and field evaluation ofthe fungus Chrysosporium lobatum against the larvae of the mosquito Culex quinquefasciatus. Parasitology Research. Volume 102, Issue 5, pp 881-886. IF=2.327 CI=18. 8. Vyas, N., Dua, K. K. and Prakash, S (2007): Efficacy of Lagenidium giganteum metabolites on mosquito larvae with reference to nontarget organisms. Parasitology Research. Volume 101, Issue 2, pp 385-390. IF=2.327 CI=26. 9. Priyanka, Srivastava IN, Prakash S (2001): Chrysosporium tropicum efficacy against Anopheles stephensi larvae in the laboratory. Journal of the American Mosquito Control Association 17(2):127-130. IF=0.827 CI=19. 10. Mohanty, SS, Prakash S (2000): Laboratory evaluation of Trichophyton ajelloi, a fungal pathogen of Anopheles stephensi and Culex quinquefasciatus. Journal of the American Mosquito Control Association 16(3):254-257 IF=0.827 CI=13.

322

ROY, JAGAT KUMAR (b 1957), Professor, Banaras Hindu University, Varanasi

Member of the NASI: No (YON 2015, Animal Sciences)

Using Drosophila as his model system, Prof. Jagat Kumar Roy has made significant contributions to chromosome organization and regulation of gene expression during development and differentiation. He unraveled the dynamic organization of heterochromatin and its differential replication in larval brain. His group showed regulation of developmental genes in Drosophila by the classical tumour suppressor genes. His elegant demonstration that homeotic transformation following perturbation in a segment polarity gene generates wings in all three thoracic segments (Emerald & Roy 1997, Nature 389:684) explains evolution of insect wings. His current research attempts to understand the molecular pathways regulated by Rab11, a G-protein-coding gene involved in vesicular trafficking. Using sophisticated genetic screens and confocal microscopy, he showed how Rab11 affected diverse cellular functions like membrane morphogenesis, cytoskeletal organization, cell adhesion, etc., as well as morphogenesis, viz., formation of eye, myogenesis and gonadogenesis. His studies also characterized development of malignant tumour in Drosphila brain due to mutaion in the dcp2 gene, coding for an RNA degradation protein. Dr Roy’s recent interest in the molecular etiology of cervix cancer has demonstrated the prevalence of HPV in women in eastern India and has shown that mutation in BRN3A is an important cellular factor in cervix cancer, which opens a novel approach in understanding of its molecular pathogenesis. Besides his sustained research contributions, Prof. JagatKumar Roy is one of the most popular teachers among students. His single minded exemplary commitment to teaching and research, and work ethic provide inspiration to students and colleagues alike. Proposer : Prof. Rajiva Raman, Seconder : Prof.Subhash Chandra Lakhotia Ten Best Publications: 1. Lakhotia S C, Roy J K, Kumar M (1979): A study of heterochromatin in Drosophila nasuta by the 5- bromodeoxyuridine-Giemsa staining technique. Chromosoma 72, 249-255 (if=3.26, ci=11) 2. Lakhotia S C, Roy J K (1981): Effects of Hoechst 33258 on condensation patterns of hetero- and euchromatin in mitotic and interphase nuclei of Drosophila nasuta. Exp Cell Res 132, 423-431 (if=3.557, ci=12) 3. Emerald B S, Roy J K (1997): Homeotic transformation in Drosophila. Nature 389, 684 (if=42.351, ci=9) 4. Emerald B S, Roy J K (1998): Organizing activities of engrailed, hedgehog, wingless and decapentaplegic in the genital discs of Drosophila melanogaster. Dev Genes Evol 208, 504-516 (if=2.179, ci=18) 5. Alone D P, Tiwari A K, Mandal L, Li M, Mechler B M, Roy J K (2005): Rab11 is required during Drosophila eye development. Int J Dev Biol 49, 873-879 (if=2.879, ci=31). 6. Sasikumar S, Roy J K (2009): Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia. Genesis 47:32-39 (if=2.042, ci=8). 7. Bhuin T, Roy J K. (2009): Rab11 is required for myoblast fusion in Drosophila. Cell Tissue Res 336, 489-499 (if=3.333, ci=12). 8. Tiwari A K, Roy J K (2009): Mutation in Rab11 results in abnormal organization of ommatidial cells and activation of JNK signaling in Drosophila eye. Eur J Cell Biol 88, 445-460 (if=3.699, ci=8). 9. Singh D, Roy J K (2013): Rab11 plays an indispensable role in the differentiation and development of the indirect flight muscles in Drosophila. PlosOne 8, e73305 (if=3.73). 10. Bhuin T, Roy J K (2014): Rab proteins: the key regulators of intracellular vesicle transport. Exp Cell Res 328, 1-19 (if=3.557, ci=2).

323

CHANDRA, GOUTAM (b 1963), Professor, Department of Zoology, The University of Burdwan, West Bengal, India

Member of the NASI: No (YON 2014, Animal Sciences)

The nominee has established 3rd quadrant of night (12 midnight - 3 a.m.) as peak period of filarial transmission (Chandra, 1995), method of computing vector survival rate per gonotrophic cycle (Chandra et al.,1996) and Anopheles subpictus(A) as malaria vector (Chatterjee and Chandra, 2000) as a part of epidemiology and vector biological studies. Control of vector borne diseases relies principally on vector control (WHO, 1999). Major breakthrough is establishment of a number of bio-resources like some novel fishes and insects as mosquito predators (Chandra & Chatterjee, 1996; Chatterjee et al., 1997; Ghosh et al., 2004, 2005, 2006; Mandal et al., 2008; Chandra et al., 2008a, 2008b, 2013; Ghosh & Chandra, 2011; Mondal et al., 2014) and some novel phyto mosquitocides like steroids, proteins, aliphatic amides, Glucosisaustrin etc. (Chowdhury et al., 2007, 2008; Ghosh et al., 2008, 2012; Banerjee et al., 2012; Rawani et al., 2012, 2014). With the extension of nanotechnology, we have synthesized silver nano particles by treating AgNO3 with plant extracts of Drypetes roxburghii and Solanum nigrum and established their mosquitocidal activities after proper characterization (Haldar et al., 2012; Rawani et al., 2013). During search of mosquito control agents, we have isolated some wormicidal, molluscicidal and bactericidal phytochemicals as byproducts (Bhattacharjee et al., 2006; Chatterjee et al., 2009; Hossain et al., 2012, 2013). In addition, locally isolated Geobacillus thermodenitrificans was proved non- mosquitocidal but a bioremidiator of some heavy metals (Chatterjee et al., 2010). Functional response of some mosquito predators has been documented (Mondal et al., 2014; 2017). Proposer: Late.Prof. V. P. Sharma, Seconder: Prof. Dr. Anupam Chatterjee. Ten Best Publications: 1. A Ghosh, N Chowdhury, G Chandra (2012): Plant extracts as potential mosquito larvicides. Indian Journal of Medical Research, 135 (May), 581-598. (if=2.061, ci=246). 2. G Chandra, I Bhattacharjee, SN Chatterjee, A Ghosh (2008): Mosquito control by larvivorous fish. Indian Journal of Medical Research 127 (1), 13 (if=2.061, ci=137). 3. A Ghosh, BK Das, A Roy, B Mandal, G Chandra (2008): Antibacterial activity of some medicinal plant extracts. Journal of natural medicines 62 (2), 259-262 (if=1.670, ci=135). 4. N Chowdhury, A Ghosh, G Chandra (2008): Mosquito larvicidal activities of Solanum villosum berry extract against the dengue vector Stegomyia aegypti. BMC Complementary and Alternative Medicine 8 (1), 10 (if=2.195, ci=124). 5. I Bhattacharjee, SK Chatterjee, S Chatterjee, G Chandra (2006): Antibacterial potentiality of Argemone mexicana solvent extracts against some pathogenic bacteria. Memorias do Instituto Oswaldo Cruz 101 (6), 645-648 (if=1.789, ci=117). 6. SK Chatterjee, I Bhattacharjee, G Chandra (2010): Biosorption of heavy metals from industrial waste water by Geobacillus thermodenitrificans. Journal of hazardous materials 175 (1), 117-125 (if=4.836, ci=106) 7. A Ghosh, N Chowdhury, G Chandra (2008): Laboratory evaluation of a phytosteroid compound of mature leaves of Day Jasmine (Solanaceae: Solanales) against larvae of Culex quinquefasciatus and nontarget organisms. Parasitology research 103 (2): 271-277 (if=2.027, ci=80). 8. A Rawani, A Ghosh, G Chandra (2010): Mosquito larvicidal activities of Solanum nigrum L. leaf extract against Culex quinquefasciatus Say. Parasitology research 107 (5), 1235-1240 (if=2.027, ci=68). 9. KM Haldar, B Haldar, G Chandra (2013): Fabrication, characterization and mosquito larvicidal bioassay of silver nanoparticles synthesized from aqueous fruit extract of putranjiva, Drypetes roxburghii (Wall.). Parasitology research 112 (4), 1451-1459 (if=2.027, ci=58). 10. A Rawani, A Ghosh, G Chandra (2013): Mosquito larvicidal and antimicrobial activity of synthesized nano-crystalline silver particles using leaves and green berry extract of Solanum nigrum L.(Solanaceae: Solanales). Acta tropica, 128 (3), 613-622 (if=2.682, ci=48).

324

CHAUHAN, RAMSWAROOP SINGH (b 1958), Professor, Veterinary Pathology, GBPUAT Pantnagar, Uttarakhand

Member of the NASI: No (YON 2014, Animal Sciences)

During his tenure as academician and scientist, he has written 73 books including 21 manuals and 1 monograph; most of them are very popular among the students world over. He contributed 80 chapters in different books and published 188 research papers in various National and International journals of repute. Besides, he participated in 16 International and 57 National Conferences. He also popularizes the scientific research by publishing 322 semi-technical articles in various magazines. He is life member of 15 scientific bodies and has bee n in several executive committee such as Chairman, President,Secretary-General,Vice President, Registrar, ICVP, etc. Based on his contributions and scientific achievements, he has been awarded with several prizes, medals and honours including Best Young Scientist Award (1992), IAAVR Award (1996), National Fellow Award (1999), Fellow NAVS (2000), Fellow SIIP (2001), K.S. Nair Memorial Award (1999), Vigyan Bharti Award (2000), Dr. C.M. Singh Trust Award (2002), Dr. Rajendra Prasad Award (2002), Shri Ramlal Agrawal National Award (2000), Best Teacher Award (2004) by GB Pant University, Pantnagar, Fellow, IAVP (2006), Gopalgaurav, Bharat Excellence Award (2007), Diplomat, ICVP (2008), etc. in recognition of his research and teaching endeavor. He has been the principle investigator of 19 research projects worth millions of Rupees. The scientific contributions of Dr. Chauhan have been recognized internationally as visiting Professor, University of Wageningen, The Netherlands and Temporary Advisor, WHO (Geneva). Dr. Chauhan ambitiously implemented quality management system (QMS) in CADRAD/ CDDL. CADRAD is the first veterinary diagnostic institution in India to get ISO certification. He also implemented uniform diagnostic methodology in all the Disease Diagnostic Laboratories throughout India.

Proposer : Prof U C Srivastava, Seconder : Prof G K Srivastava Ten Best Publications:

1. Tikaram SM, Satija KC, Chauhan RS and Kaushik RK.(1987): Orchitis in a camel (Camelus dromedarius) infected with Sarcoptes cameli. Veterinary Parasitology, 23: 307-309. (if=2.016). 2. Chauhan RS and Kaushik RK. (1987): Isolation of camel pox virus in India. British Veterinary Journal. 143: 581-582. (if=1.755). 3. Chauhan RS and Kaushik RK. (1991): Isolation of enterotoxigenic Escherichia coli from camels with diarrhoea. Veterinary Microbiology. 29: 195-197. (if=2.01). 4. Chand P, Sadana JR, Batra HV and Chauhan RS. (1989): Comparison of the dot immunobinding assay with the complement fixation test for the detection of Brucella antibodies in sheep. Veterinary Microbiology. 20: 281-187. (if=2.01). 5. Chauhan RS and Singh NP(1992): Cell-mediated immune response in rotavirus infected calves- Leucocyte migration inhibition assay. Journal of Comparative Pathology. 107: 115-118. (if=1.494) 6. Chauhan RS and Singh NP.(1992):Rapid diagnosis of rotavirus infection in calves by dot immunobinding assay. Veterinary Record. 130: 381. (if=1.087). 7. Singhal LK, Bagga S, Kumar R and Chauhan RS. (2003): Down regulation of humoral immunity in chickens due to carbendazim. Toxicology In Vitro, 17(5-6): 687-692. (if=2.193). 8. Ravindra PV, Tiwari AK, Ratta B, Chaturvedi U, Palia SK, Subudhi PK, Kumar R, Sharma B, Rai A and Chauhan RS. (2008): Induction of apoptosis in vero cells by Newcastle disease virus requires viral replication, de-novo protein synthesis and caspase activation. Virus Research, 133: 285-290. (if=2.81). 9. PV Ravindra, Ashok K Tiwari, Barkha Ratta, Manish V Bais, Uttara Chaturvedi, Sudesh Palia, Bhaskar Sharma, and R S Chauhan (2009): Time-course induction of Newcastle disease virus-induced extrinsic and intrinsic apoptotic pathways in infected cells. Virus research, 144 (1-2): 350-354. (if=2.81). 10.PV Ravindra, Ashok K Tiwari, Barkha Ratta, Uttara Chaturvedi, Sudesh Kumar Palia, and RS Chauhan (2009): Newcastle disease virus-induced cytopathic effect in infected cells is caused due to apoptosis. Virus Research, 141: 13-20. (if=2.81). 325

GHOSH, SUKLA (b 1958), Professor, Department of Biophysics,MolBIo&BI, Calcutta University, Kolkata

Member of the NASI: No (YON 2014, Animal Sciences)

Dr. (Ms) SUKLA GHOSH is an established investigator in the area of Developmental Biology especially Regeneration Biology. In her post-doctoral work on craniofacial and limb regeneration in newt and salamanders, different tissue specific genes during regeneration were identified resulting in seminal publications (Ghosh et al 1994, 1996, Ferretti and Ghosh 1997). Her study on limb regeneration in axolotl led to functional analysis of genes by successful use of viral vectors (Ghosh et al 2008). On her return to India in 2004, initially at and subsequently at the University of Calcutta, she reestablished facilities for working on spinal cord regeneration in Zebra Fish and Axolotl. Not only these models were validated, this work led to publications of high standard on the molecular basis of this process (Hui et al. 2010, Hui et al 2013, Hui et al 2014). A recent work from her laboratory, published in PLoS ONE, uncovered the molecular basis of spinal cord regeneration by transcriptome profiling and in the process identifying several groups of event specific genes, some of which could be targeted for future therapeutic purpose. This is a signal contribution to this field from India. In addition to this the nominee has led the departmental efforts in streamlining and improving the quality of teaching and organizing new funding. Proposer: Prof. Kambadur Muralidhar, Seconder: Prof. Samir Bhattacharya Ten Best Publications: 1. Sukla Ghosh and Subhra Prakash Hui (2016): Regeneration of Zebrafish CNS: Adult Neurogenesis. Neural Plasticity ArticleID5815439 doi:10.1155/2016/5815439 . Impact factor 3.582 ISSN : 2090-5904 citation =5. 2. Subhra Prakash Hui, Tapas Chandra Nag, Sukla Ghosh. (2015): Characterization of proliferating neural progenitors after spinal cord injury in adult zebrafish. Plos One 10(12): e0143595. doi:10.1371/journal.pone.0143595 Impact factor 3.24 ISSN: 1932-6. 3. Subhra Prakash Hui, Dhriti Sengupta, Triparna Sen, Sudip Kundu, Serene Gek Ping Lee, Sinnakaruppan Mathavan, Sukla Ghosh. (2014): Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish PLoS ONE 9(1): e84212. https://doi.org/10.1371/journal.pone.0084212. 4. Subhra Prakash Hui James R Monaghan, S. Randal Voss and Sukla Ghosh. (2013): Expression pattern of Nogo-A, MAG and NgR in regenerating urodele spinal cord. Developmental dynamics. 242(7):847-860.Impact factor 2.668 online ISSN: 1097-0177. 5. Subhra Prakash Hui, Anindita Dutta and Sukla Ghosh (2010): Cellular response after crush injury in adult zebrafish spinal cord. Developmental Dynamics. 239:2962-2979. Impact factor 2.864 online ISSN: 1097-0177 citation = 47. 6. Ghosh, S., Roy, S., Seguin, C., Bryant, S.V., and Gardiner D. M. (2008): Analysis of the expression and function of Wnt-5a and Wnt-5b in developing and regenerating axolotl (Ambystoma mexicanum) limbs. Development Growth and Differentiation. 50:289. 7. Ghosh, S., and Dhoot, G. K. (1998): Evidence for distinct fast and slow myogenic cell lineages in human foetal skeletal muscle. J. Mus. Res. & Cell Motility. 19:431-441. Impact factor 1.981 ISSN: 0142- 4319 citation =9. 8. Ferretti, P., and Ghosh, S. (1997): Expression of regeneration associated cytoskeletal proteins reveals differences and similarities between regenerating organs. Developmental Dynamics. 210:288-304. Impact factor 3.08 online ISSN: 1097-0177. 9. Ghosh, S., Thorogood, P. V. T., and Ferretti, P. (1996): Regeneration of lower and upper jaws in urodeles is differentially affected by retinoic acid. Int. J. Dev. Biol. 40:1161-1170. Impact factor 2.959 ISSN: 0214- 6282 citation = 12. 10. Ghosh, S., Thorogood, P. V. T., and Ferretti, P. (1994): Regenerative capability of upper and lower jaws in the newt. Int. J. Dev. Biol. 38:479-490. Impact factor 2.959 ISSN: 0214- 6282 citation = 42.

326

GOSWAMI, UMESH CHANDRA (b. 1950) Department of Zoology, Gauhati University, Guwahati

Member of the NASI: Yes (YON 2014, Animal Sciences)

Professor Goswami, has (i) identified the vitamin A- rich fishes available from the Brahmaputra river system (Goswami and Barua 1981 a,b,c) and has shown (ii) that both retinol (vitamin A1) and dehydroretinol (Vitamin A2) can be synthesized by the fish either through central or terminal cleavage of pro-vitamin A - status carotenoids (Goswami & Bhattacharya, 1982, Goswami 1984,a,b; Barua & Goswami 1977; Goswami and Barua, 1981, a,b,c) such as β-carotene lutein, cryptoxanthin, astaxanthin, apocarotenals. Vitamin A2 is synthesized from lutein, cryptoxanthin or astaxanthin through anhydrolutein, 3-hydroxyanhydroretinol and rehydrovitamin A2. (Goswami 1984, a, b; 2006, 2007). (iii) He has shown that chemically induced carcinogenesis viz Aflatoxin B1- DNA adduct and benzopyrene induced stomach tumor could be controlled by naturally occurring vitamin A2 derivatives found in fish liver oil such as 3-hydroxyretinol, 3-hydroxyanhydroretinol dehydroretinol, etc (Goswami et al.1989, 1991; Shah et al. 1992; Azune et al. 1992; Kayal et al.1993; Abobaker et al.1987; Goswami et al. 1991, 1995; Goswami and Sanna 1995) (vii) He has shown that retinoids are essential for the growth and reproduction of fish (Goswami and Basurnatary 1988) (viii) Established the relationship between retinol & β-carotene) and thyroid hormone (T3 and T4), where hyperthyroidism lowers the retinoids status, where as hypothyroidism elevates the retinol & β-carotene. (Goswami & Choudhury 1999) (ix) Further showed that various effects of narcotic drugs such as heroin could be ameeoliorate through the introduction of carotenoids (Saha et al. 2012).

Proposer : Prof. Samir Bhattacharya, Seconder : Prof. Shelley Bhattacharya

Ten Best Publications: 1. Barua A.B and Goswami, U.C.(1977): Formation of vitamin A in freshwater fish. Biochem. J. 164 : 133- 136. (If= 8.2, ci=64). 2. Goswami, U.C. and Barua, A.B. (1981): Origin of retinol in freshwater fish. Curr. Sci. 50: 150-151. (if=7.4, ci=42). 3. Goswami, U.C.and Barua, A.B. (1981): Distribution of retinol and dehydroretinol III freshwater fish. Indian J. Biochem. Biophys. 18 : 383-385. (if=7.5, ci=50). 4. Goswami, U.C. and Barua, A.B. (1981): Intestinal conversion of lutein into 3-dehydroretinol in Heteropneustes fossilis and Channa striatus. IndianJ. Biochem. Biophys. 18.88. (if=7.5, ci=39). 5. Goswami, U.C. and Bhattacharya, S. (1982): Biosynthesis of 3-dehydroretinol : Metabolism of lutein (Beta-E-carotene, 3-3' diol) in Clarias batrachus and Ompok pabo. Biochem. Internat. 5(4) :545-552. (if=8, ci=41). 6. Goswami, U.C. (1984): Metabolism of cryptoxanthin in freshwater fish. Br. J.Nutr. 52 : 575-581. (if=7.9, ci=45). 7. Goswami, U.C. and Basumatari, G. (1988): Vitamin A-deficient diet and its effects on the body weight of dehydroretinol-rich freshwater fish. Internat. J. Vit. Nutr. Res. 58:267-275. (if=6, ci=25). 8. Goswami, D.C.; Saloi, T.N.; Firozi, P. and Bhattacharya, R.K.B. (1989): Modulation of by natural carotenoids of DNA-adduct formation by aflatoxin B 1 in vitro. Cancer Lett. 344 : 213-217. (if=8.1, ci=44). 9. Goswami, D.C. and Sharma, N. (2005): Efficiency of a few retinoids and carotenoids in vivo in controlling the benzo (a) pyrene induced forestomach tumor in female swiss mice. Br.J.Nutr.95:1-5 (if=7.9, ci=32). 10. Goswami, D.C. and Choudhury, S.(1999): Status of retinoids in women suffering from hyper and hyprothyroidism : Interrelationship between Vitamin A, Beta-carotene and Thyroid hormones. Internet. J. Vit. Nutr. Res. 69(2):132-135 (if = 6, ci = 22).

327

JAIN, SUBODH KUMAR (b 1958), Professor & HOD-Biotechnology, Dr. H.S. Gour University, Sagar, MP

Member of the NASI: Yes (YON 2014, Animal Sciences)

Prof. Subodh Kumar Jain initially worked in the field of remediation of metal toxicity through natural ion exchangers in fish and suggested the ionic heavy metal replace other cation on zeolites and also they may be used to increase body weight (Jain, 1999). He established a set of biomarkers through RAPD- PCR based approach for genetic characterization (Neekhra et al. 2012). He studied the stimuli-specific role of vasopressin in the hypothalamo-pituitary-adrenal axis in response to various stress regulation (Zelena et al. 2009), oxytocin and vasopressin are important in stress and stress related disorders (Zelena and Jain 2009). The role of vasopressin is especially critical during perinatal period as it regulate the adrenocorticotropin secretion in a time and stressor specific manner (Zelena and Jain, 2010). He proved the gender specific involvement of endogenous glutamate neurotransmission on stress-induced fear and females are more sensitive, therefore require smaller doses subject to prolactin level monitoring (Jain and Zelena, 2011). He established the regulatory role of dopamine, serotonin and TRH on PRL secretion, and the endogenous glutamate can through NMDA receptor subtype contribute to the VIP- induced PRL secretion by anterior pituitary. This regulation is important during suckling and stress response when rapid release of PRL is required (Jain and Zelena, 2013). He has coordinated practical workshop of science communication program of NASI (October 3-4, 2013) and also coordinated winter school 2015 organised by NASI under the guidance and presence of Prof. U.C. Srivastava of NASI, Allahabad. I strongly recommend him for the award of NASI fellowship. Proposer : Prof. U.C.Srivastava, Seconder : Prof. G.K. Srivastava Ten Best Publications : 1. Subodh Kumar Jain, A. K. Raizada, S. Shrivastava and K. Jain (1996): Proctective action of zeolite on lead toxicity in fresh water fish. Fresenius Environ. Bull. Germany, 5: 466-468. (IF 0.372/Citation 13). 2. Subodh Kumar Jain :(1999): Protective role of zeolite on short and long term lead toxicity in the teleost fish Heteropneustes fossilis. Chemosphere, Elsvier science, Oxford, England, 39(2), 247-251. (Impact Factor 3.698/Cited Index 29). 3. Mishra, P.K., Panwar, H., Bhargava, A., Raghuram, V., Jain, Subodh Kumar, Banerjee, S. and Maudar, K.K.:(2008): Isocynates induces DNA damage apoptosis, oxidative stress and inflammation in cultured human lymphocytes. J. Biochem. Molecular Toxicology 22 (6) 429 – 440 (Impact Factor 2.303; Citation Index 46). 4. Dora Zelena, Agnes Domokos, Subodh Kumar Jain, Ryan Jankord and Ludmila Filaretova (2009): The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress. Journal of Endocrinology 202, 263-278.(Impact Factor 4.498, Citation Index 41). 5. Jain, Subodh Kumar; Neekhra, B.; Pandey D.; Jain, Kalpana (2010):RAPD Marker System in Insect Study: A review. Indian Journal of Biotechnology vol 9, January , pp 7-12 (ISSN 0972-5849; Impact Factor 0.385/Citation Index 31) 6. Khan S, Raghuram GV, Bhargava A, Pathak N, Jain SK, Mishra PK (2011) : Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus. Translational Research vol.158 No.6, 344-359 (Impact Factor 4.557/Citation Index 38). 7. Mishra, P.K.; Raghuram, GV; Bhargava, A; Ahirwar, A; Samarth, R; Upadhyaya, R; Jain, Subodh Kumar; Pathak, Neelam.(2011): In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris. British Journal of Nutrition 106, 1154-1168. (Impact Factor 3.311/Citation Index 34) 8. Arpit Bhargava, Dinesh K. Mishra, Subodh Kumar Jain, Rupesh K. Srivastava, Nirmal K. Lohiya, Pradumna K. Mishra.( 2016): Comparative assessment of lipid based nano-carrier systems for dendritic cells based targeting of tumor reinitiating cells in gynecological . Molecular Immunology, 79; 98- 112. (Impact Factor 3.375) 9. Subeer Majumdar, Abul Usmani, Nirmalya Ganguli, Subodh K. Jain, Nilanjana Ganguli, Rajesh Sarkar, Mayank Choubey, Mansi Shukla and Hironmoy Sarkar.(2016): Robust generation of transgenic mice by simple hypotonic solution mediated delivery of transgene in testicular germ cells. Molecular Therapy- methods and Clinical Development: 3, 16076 doi:10.1038/mtm.2016.76. (Impact Factor 6.938/Citation Index 04). 10. Bhargava A, Khare NK, Bunker N, Choudhary K, Pandey KC, Jain Subodh Kumar, Mishra PK.(2016): Cell free circulating epigenomic signatures: Non invasive biomarker for cardiovascular and other age related chronic diseases. Current Pharmaceutical Design (Benthem Science) Vol.22 doi.10.2174/1381612822666161027145359, (IF 3.052). Technology transferred/Patent, if any: N.A. Fellowship/Award: Prof. G.K.Manna Award (2013-2014). 328

RAMACHANDRAN, SUNDARARAJ (b 1963), Scientist G and Head, Forest and Wood Protection Division, Institute of Wood Science and Technology, Bangalore

Member of the NASI: Yes (YON 2014, Animal Sciences)

Dr. R. Sundararaj, enjoys an established reputation for his outstanding contributions on bio-diversity, bio- ecology and management of harmful forest pests. His work on these aspects has received international acclaim not only for its scientific merit, but also for its practical application in controlling insect pests. His election as a Fellow of Royal Entomological Society (London) stands testimony to the world-wide recognition. He is an authority on taxonomy of Indian whiteflies, erected eight genera, described 139 species new to science and reported twelve species of these pests for the first time from India. Recently he has reported the invasion and establishment of solanum whitefly on solanceous and medicinal plants; and rugose spiraling whitefly on coconut in south India thereby helped the Ministry of Agriculture and Farmer’s welfare to issue alert and advisory notifications. He has thoroughly investigated the entomofaunal diversity and their interactions in sandal-wood dominated ecosystems and also the insect pests of sandalwood under cultivation. Developed integrated pest management strategies and now, actively involving in training the farmers on the eco-friendly way of managing insect pests of sandalwood. In, addition, developed integrated management strategies against insect pests of important tree species and of their nurseries. The novelty and uniqueness of these scientific contributions have, indeed, making a scholastic impact in the context of protecting our forest wealth. His contributions on the natural bio- resistance of imported timbers are of practical importance in guiding wood industry and wood consumers. Successfully guided 11 Ph.D. students and presently guiding three PDFs. Proposer: Dr. L.N.Santhakumaran, Seconder: Prof. A. Jagannadha Rao Ten Best Publications: 1. Sundararaj, R. and Reuben, R. (1992): Evaluation of microgel droplet formulation of Bacillus sphaericus 1593M (Biocide S) for control of mosquito larvae in rice fields in Southern India. Journal of American Mosquito Control Association,7: 556 559. (if=0.83, ci=18). 2. Sundararaj, R. and David, B.V.(1993): New species of Aleuroclava Singh from India (Homoptera: Aleyrodidae). Oriental Insects, 27: 233-270. (if=0.18, ci=29). 3. Dubey, A.K. and Sundararaj, R. (2006): Distinctaleyrodes setosus Dubey& Sundararaj (Sternorrhyncha: Aleyrodidae), a new whitefly genus and species from India. Zootaxa, 1154: 35-39 (if=1.06, ci=12). 4. Sundararaj, R. (2007): On the genera Cockerelliella Sundararaj & David and Pseudcockerelliella Sundararaj gen. nov. with a key to the Indian genera of Aleyrodidae (Hemiptera). Oriental Insects, 41: 243-257. (if=0.36, ci=16). 5. Dubey, A.K and Sundararaj, R. (2008): Are polyphagousaleyrodids more diverse in puparial morphology. Current Science, 94 (8): 968-969. (if=0.569, ci=9). 6. Sundararaj, R. and Rajamuthukrishnan (2011): Population dynamics of some coccids (Coccoidea: Hemiptera) infesting sandal (Santalum album Linn.) in Bangalore, India. Journal of Forestry Research, 22 (2): 259-262 (if=1.47, ci=11). 7. Shanbhag, R.R., Sundararaj, R. (2013): Imported wood decomposition by termites in different agro-eco zones of India. International Journal of Biodeterioration& Biodegradation, 85: 16-22. (if=2.44, ci=8). 8. Sundararaj, R., Shanbhag, R.R., Nagaveni, H.C. and Vijayalakshmi, G. (2015): Natural durability of timbers under Indian environmental conditions- An overview. International Biodeterioration & Biodegradation 103:196-214. (if=2.43, ci=11). 9. Shanbhag, R.R. Meyssoun, K., Sundararaj, R and Pascal, J. (2017): Rainfall and soil properties influence termite mound abundance and height: A case study with Odontotermes obesus (Macrotermitinae) mounds in the Indian Western Ghats forests. Applied (if=2.67). 10. Sundararaj, R. and Selvaraj, R. (2017): Invasion of rugose spiraling whitefly, Aleurodicus rugioperculatus Martin (Hemiptera: Aleyrodidae): a potential threat to coconut in India. Phytoparasitica, DOI 10.1007/s12600-017-0567-1-4. (if=1.03).

329

SHARMA, RAMESH CHANDRA (b 1954), Professor & Head, Department Of Environmental sciences, H.N.B. Garhwal University (A Central University) Srinagar-Garhwal,Uttarakhand

Member of the NASI: No (YON 2014, Animal Sciences)

Prof. Ramesh C. Sharma,D.Phil.,D.Sc.,FASc.,FZSI,FNESA,FSB;FAEB;FIESA has done a very good work on environmental biology of Himalayan fish. He has made a significant contribution on freshwater biodiversity including diversity of phytoplankton, periphyton, zooplankton, zoobenthos and fish dwelling Himalayan rivers and wetlands. He was also able to identify the potential bioindicator for assessing the health of aquatic ecosystems. He has made contribution on traditional wisdom (Sacred groves) for biodiversity contribution and indigenous device (water mills) for sustainable development of renewable hydroenergy in Uttarakhand Himalayas. Recently, he has made significant contributions on the assessment of organchlorine pesticides in soil, sediments, human blood and milk. In addition to it, he is an environment expert of World Bank for hydropower developments in the Himalayas.I am pleased to certify that I am personally acquainted with the scientific work of Prof. Sharma. Proposer: Prof. M. Shamim JairajpurIi Seconder: Prof.S.P.Singh Ten Best Publications: 1. Mishra, K. and Sharma, R.C. (2011): Assessment of organochlorine pesticides in human milk and risk exposure to infants from North-East India. Science of the Total Environment, 409:4939–4949 (if=3.258, ci=15). 2. Mishra, K., Sharma, R.C. and Kumar S. (2011):Organochlorine pollutants in human blood and their relation with age, gender and habitat from North-east India. Chemosphere :85:454-464, (if=3.206, ci=8). 3. Mishra, K., Sharma, R.C. and Kumar S. (2011): Contamination levels and spatial distribution of organochlorine pesticides in soils from India. Ecotoxicology and Environmental Safet, 76(2) : 215-225 (if=2.617, ci=13). 4. Sharma,R. C., Bisht Y.S., Sharma R. and Bhandari D.S. (2008): Gharats (Watermills): Indigenous device for sustainable development of renewable hydro-energy in Uttarakhand Himalayas. Renewable Energy 33: 2199-2206. (if=3.2, ci=4). 5. Sharma A., Sharma R.C. and Anthwal A. (2007): Monitoring Phytoplankton diversity in the hillstream Chandrabhaga in Garhwal Himalayas. Life Sciences Journal 4(1): 80-84 (if=2.732, ci=4). 6. Sharma, R.C. and Rawat J.S. (2009): Monitoring of aquatic macroinvertebrates as bioindicator for accessing the health of Asan Conservation Reserve, India: A case study. Ecological Indicators 9:118-128 Springer-Verlag. (if=3.021, ci=28). 7. Anthwal, A., Sharma, R.C. and Sharma, A. (2006): Sacred grooves: traditional way of conserving plant diversity in Garhwal Himalaya, Uttaranchal. The Journal of American Science 2 (2): 35-38. (if=2.716, ci=26). 8. Singh, D. and Sharma, R.C. (1998). Biodiversity, ecological status and fixing of order of priority for conservation of the fish of Alaknanda, a parent stream of Ganges (India). Aquatic Conservation : Marine and Freshwater Ecosystem, John Wiley, New York 8: 761-772. (if=1.929, ci=12). 9. Singh, D. and Sharma, R.C.(1995): Age and growth of a Himalayan teleost Scizothorax richardsonii (Gray) from Garhwal Hills (India). Fisheries Research, Elsevier, The Netherlands 24: 321-329. (if=1.887, ci=6). 10. Sharma, R.C.(1983):Trophic dynamics of Snow-trout, Schizothorax richarsoni (Gray) of Garhwal Himalaya. Indian J. Animal Sci. 54(7): 666-670. (if=0.12, ci=10).

330

VENUGOPALAN, VAYALAM PURATH (b 1960), Head, Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai

Member of the NASI: No (YON 2014, Animal Sciences)

Dr. Venugopalan is actively pursuing research on biofilms and biofouling. Settlement and growth of microorganisms on surfaces exposed to aqueous milieu has major implications in biomedical and industrial environments. His early work on biofouling on the offshore oil platforms in the Bombay High region augmented our understanding of the problem and led to selection of control options. His work on early stages of bacterial biofilm development threw new light on structural features of nascent biofilms under flow conditions and improved our understanding of their functional significance. His work on application of granular biofilms in wastewater treatment is well-recognized. He has made significant contributions in the use of granular biofilm reactors for biodegradation of organic/inorganic wastes and xenobiotics in wastewater. He has developed a photobioreactor that uses granular phototrophic biofilms for efficient treatment of wastewater. He has studied formation of biofilms in biomedical environments and developed methods to control wound bed biofilms. His scientific contributions in the area of biofouling of seawater intake systems of coastal power plants are well recognized. He has carried out extensive investigations on the impact of antifouling biocides discharged from electric power plants into coastal marine systems. A book on this subject, co-edited by him, is an important contribution to our understanding of operational and environmental issues emanating from the use of seawater as an industrial coolant. Dr. Venugopalan has brought to bear on this important field his varied experience and made substantial and lasting contributions in terms of not only publications but also technologies. Proposer: Prof. T. Subramoniam, Seconder: Prof. S. P. Thyagarajan Ten Best Publications: 1. S Rajagopal, VP Venugopalan, G Van der Velde, HA Jenner, (2006): Greening of the coasts: a review of the Perna viridis success story. Aquatic Ecology 40 (3), 273-297 (if=1.797, ci=97). 2. EH Poornima, M Rajadurai, TS Rao, B Anupkumar, R Rajamohan, SV Narasimhan and VP Venugopalan.(2005): Impact of thermal discharge from a tropical coastal power plant on phytoplankton. Journal of Thermal Biology 30 (4), 307-316 (if=1.621, ci=87). 3. DH Dusane, YV Nancharaiah, SS Zinjarde, VP Venugopalan. (2010): Rhamnolipid mediated disruption of marine Bacillus pumilus biofilms. Colloids and Surfaces B: Biointerfaces 81 (1), 242-248 (if=3.902, ci=77). 4. YV Nancharaiah, N Schwarzenbeck, TVK Mohan, SV Narasimhan, PA Wilderer and VP Venugopalan. (2006): Biodegradation of nitrilotriacetic acid (NTA) and ferric–NTA complex by aerobic microbial granules. Water Research 40 (8), 1539-1546 (if=5.991, ci=69). 5. VP Venugopalan, M Kuehn, M Hausner, D Springael, PA Wilderer and S Wuertz. (2005): Architecture of a nascent Sphingomonas sp. biofilm under varying hydrodynamic conditions. Applied and Environmental Microbiology 71: 2677-2686. (if=3.823, ci=49). 6. YV Nancharaiah, HM Joshi, M Hausner and VP Venugopalan. (2008): Bioaugmentation of aerobic microbial granules with TOL plasmid enhances benzyl alcohol biodegradation in laboratory microcosm. Chemosphere 71: 30-35. (if=3.698, ci=49). 7. EH Poornima, M Rajadurai, VNR Rao, SV Narasimhan and VP Venugopalan, (2006): Use of coastal waters as condenser coolant in electric power plants: Impact on phytoplankton and primary productivity, Journal of Thermal Biology, 31: 556–564 (if=1.621, ci=49). 8. YV Nancharaiah, VP Venugopalan, (2011): Denitrification of synthetic concentrated nitrate wastes by aerobic granular sludge under anoxic conditions. Chemosphere 85 (4), 683-688. (if=3.698, ci=39). 9. YV Nancharaiah, M Rajadurai, VP Venugopalan. (2007): Single cell level microalgal ecotoxicity assessment by confocal microscopy and digital image analysis, Environmental Science and Technology, 41(7): 2617-2621. (if=5.393, ci=39). 10. YV Nancharaiah, HM Joshi, TVK Mohan, VP Venugopalan and SV Narasimhan. (2006): Aerobic granular biomass: a novel biomaterial for efficient uranium removal. Current Science, 91: 504-509 (if=0.967, ci=67).

331

GOVINDARAJU, ARCHUNAN (b 1956), Professor and Head, Department of Animal Science, Bharathidasan University, Tiruchirappalli

Member of the NASI: Yes (YON 2013, Animal Sciences)

Dr. Archunan has been engaged in research extending the horizon of knowledge in pheromone with special reference to biology of reproduction of rodents and farm animals. He has made several discoveries like identification of rodent pheromonal compounds (Achiraman and Archunan, 2002), developing a pheromone trap for rodent pests (Selvaraj and Archunan, 2002), estrus-specific pheromones in blackbuck (Archunan and Rajagopal, 2013), cow (Rameshkumar et. al., 2008) and buffalo (Rajanarayanan and Archunan, 2011; Karthikeyan et. al., 2013) and estrus-specific proteins in house rat (Muthukumar et al., 2013; Rajesh et al., 2016) and in buffalo (Muthukumar et al., 2014a and 2014b). Having gained expertise in pheromone biology research, he developed interest to turn to pheromone technology; He has obtained a patent for buffalo urinary sex pheromones, which eventually enhance the libido in the bull. His discovery of pheromone carrier protein in rat is significant in the context of making biotrap for rodents. Farmers are highly benefited by his research contributions in terms of providing tips as well as recently developed simple kit for estrus detection in buffalo. In recognition of his unique work in mammalian sex pheromones, he has been conferred D.Sc. Considering the contribution he has made so far to science, at a rapid pace, he is confident that he will succeed in his attempt in the technological avenues. He has already carved a niche for himself in pheromone biology and pheromone technology in the international scenario, and expects to contribute much more in terms of research to the knowledge of pheromones. Proposer: Dr.G.Marimuthu, Seconder: Late Dr.G.Shanmugam Ten Best Publications: 1. Achiraman S, Archunan G (2002): Characterization of urinary volatiles in Swiss male mice (Mus musculus): Bioassay of identified compounds. Journal of Biosciences, 27: 679-686. (if=1.41, ci=20). 2. Rajanarayanan S, Archunan G (2004): Occurrence of flehmen in male buffaloes (Bubalus bubalis) with special reference to estrus. Theriogenology, 61: 861-866. (if=1.83, ci=27). 3. Sankar R, Archunan G (2004): Flehmen response in bull: Role of vaginal mucus and other body fluids of bovine with special reference to estrus. Behavioural Processes, 67: 81-86. (if=1.31, ci=21). 4. Sankar R, Archunan G (2008): Identification of putative pheromones in bovine (Bos taurus) faeces in relation to estrus detection. Animal Reproduction Science, 103: 149-153. (if=1.37, ci=22). 5. Achiraman S, Ponmanickam P, Sankar Ganesh D, Archunan G (2010): Detection of estrus by male mice: Synergistic role of olfactory-vomeronasal system. Neuroscience Letters, 477: 144-148. (if=2.10, ci=21). 6. Muthukumar S, Rajesh D, Saibaba G, Alagesan A, Rengarajan RL, Archunan G (2013): Urinary lipocalin protein in a female rodent with correlation to phases in the estrous cycle: An experimental study accompanied by in silico analysis. PlosOne. 8: e71357. (if=3.54, ci=5). 7. Muthukumar S, Rajkumar R, Karthikeyan K, Liao CC, Singh D, Akbarsha MA, Archunan G (2014): Buffalo Cervico-Vaginal Fluid Proteomics with Special Reference to Estrous Cycle: Heat Shock Protein (Hsp)-70 Appears to Be an Estrus Indicator. Biol Reprod, 90 (if=3.31, ci=3). 8. Muthukumar S, Rajkumar R, Rajesh D, Saibaba G, Liao CC, Archunan G, Padmanabhan P, Gulyas B (2014): Exploration of salivary proteins in buffalo: An approach to find marker proteins for estrus. The FASEB Journal, 28: 1-10. (if=5.29, ci=2). 9. Ilayaraja R, Rajkumar R, Rajesh D, Muralidharan AR, Padmanabhan P, Archunan G (2014): Evaluating the binding efficiency of pheromone binding protein with its natural ligand using molecular docking and fluorescence analysis. Scientific Reports, 4: (if=5.28, ci=3). 10. Rajesh D et al. (2016): Structural elucidation of estrus urinary lipocalin protein (EULP) and evaluating binding affinity with pheromones using molecular docking and fluorescence study: Scientific Reports, 6: 35900. (if=5.28, ci=0).

332

HALDAR, CHANDANA (b 1952), Professor and Head, Department of Zoology, Banaras Hindu University, Varanasi

Member of the NASI: Yes (YON 2013, Animal Sciences)

Professor Haldar, a renowned melatonin biologist of International repute, working on the intricacies of pineal with eco-physiological changes governing the level of melatonin in management of seasonal reproduction and immunity. As a comparative endocrinologist she explored the structural/functional details of pineal in reptiles, birds and mammals. She devised a method for pinealectomy in Indian tropical animals and initiated the era of pineal research in India. •Established pineal organ culture to explore the functional importance of pineal proteins. •Developed radioimmunoassay (RIA) of melatonin. •Established the role of pineal in modulation of Bone marrow cell (GM-CFU)function. .Sequenced the melatonin receptor subtype MT1 and nuclear receptor ROR (JX227944) in Indian squirrel, Mel1b & c receptors in Indian jungle bush quail(JX535291) •Established the free radical scavenging potentials of melatonin in gonad and lymphoid organs. •Established molecular mechanism of melatonin action & its correlation with clock genes and immune functions. •Immunocytochemically localized the presence of Serotonin, Rhodopsin, estrogen, , glucocorticoid receptors in pineal cells. •Having 300 papers in International and national peer reviewed journals. •Produced 39 Ph.Ds; Guided 4 MD/MS thesis & several summer trainees( INSA Bangalore), Womens scientist and DST-YS; DSK-UGC Fellows. •Received IBRO-UNESCO, JSPS, CNRS, Alexander von Humboldt Fellowship and equipment subs. Award, INSA-Young scientist 1983/84; UGC-BSR one time grant. .Life ,members of FASEB,Melatonin club & EPS France,AOSP Japan, SRBCE-Taramani, ISSRF-Jaipur ISC-Delhi •EX-President of National (SRBCE, LASAI and IPSG)and International (AOCP) •Completed projects from CSIR/UGC/DST/BRNS/INSA/DBT and AvH Germany with a fund of approx. Rs. 2 Crores + of 29,000 Euros=Rs. 20,64,000/-. Proposer: Prof. B.N. Singh, Seconder: Prof. M.K. Thakur Ten Best Publications: 1. Pandey S K, Haldar C, Patel D K and Maiti P (2013): Biodegradable polymers for potential delivery systems for therapeutics. Advances in Polymers Science 254: 169-202 (if=6.72, ci=7). 2. S. Gupta and C. Haldar (2013): Physiological cross-talk between melatonin and glucocorticoid receptor modulate T cell mediated immune responses in a tropical rodent F.penannti. J Steroid Biochem. and Mol. Biol. Vol. 134;23-36 (if=3.9, ci=28). 3. D. K. Vishwas, A. Mukherji; C. Haldar, D. Dash and M.K. Nayak (2013): Improvement of oxidative stress and immunity by melatonin: An age dependent study in golden hamster; Exp. Genrontology. 48; 168-182. (if=3.7, ci=21). 4. Amaresh Kumar Singh and Chandana Haldar (2014): Age dependent nitro oxidative load and melatonin receptor expression in spleen and immunity of goat Capra hircus. Exp Gerontol. 2014 Dec; 60 :72-8. (if=3.5, ci=3). 5. Arun Mukherjee and Chandana Haldar (2015): Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study. Exp Gerontol. 69:211-220. (if=3.4, ci=2). 6. Sanjeev K Pandey, Chandana Haldar, DK Vishwas, P Maiti (2015): Synthesis and in vitro evaluation of melatonin entrapped PLA nanoparticles: An oxidative stress and T-cell response using golden hamster. J Biomed Mater Res A. 103(9):3034-44. (if=3.4, ci=1). 7. Soumik Goswami and Chandana Haldar. (2015): Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview. J Photochem Photobiol B.153:281- 8. (if=3.13, ci=3). 8. Jyoti Singha, Ashish Dwivedi, Syed Faiz Mujtaba, Krishna P. Singh,Manish Kumar Pal, Deepti Chopra, Shruti Goyal, Ajeet K. Srivastav, Divya Dubey, Shailendra K. Gupta, Chandana Haldar, Ratan Singh Ray. (2016): Ambient UV-B exposure reduces the bind (if=4, ci=1). 9. Amaresh Kumar Singh, Chandana Haldar (2016): Melatonin modulates glucocorticoid receptor mediated inhibition of antioxidant response and apoptosis in peripheral blood mononuclear cells, Mol Cell Endocrinol, 436: 59-67. (if=3.9, ci=1). 10. Sameer Gupta and C. Haldar (2017): Short day length enhances physiological resilience of the immune system against 2-deoxy-D-glucose-induced metabolic stress in a tropical seasonal breeder Funambulus pennanti, Hormones and Behaviour, 89: 157-166. (if=3.3, ci=0).

333

KADARKARAI, MURUGAN (b 1961), Professor and Head, Dapartment of Zoology, Bharathiar University,

Member of the NASI: No (YON 2013, Animal Sciences)

Any meaningful approach to modern science is adoption of interdisciplinary trends, an aspect more relevant to biological science today. From this perspective, Nominee, Dr. K. Murugan have contributed regularly to the advancement of knowledge in the area of insect-plant interactions with special reference to biological control of insects by using botanicals, microbial insecticides and nanoparticles. The research investigations have been published in highly reputed Science Direct Journals. Dr. K. Murugan has done front line research on the effect of plant compounds with microbial insecticides for the successful control of crop insect pests. Dr. Murugan has utilized major funding facilities from DRDO (Ministry of Defence, Govt. of India), UGC, CSIR, DST for the control mosquito vectors and developed biopesticides for the control of malarial, filarial, and dengue/chikungunya vectors. Also the nominee has developed collaborative research between the Defence Laboratory, Tezpur Assam, Delhi University, USDA, Florida, National Taiwan University, Chinese Academy of Sciences, Beijing, University of Sappenza, Rome, Italy for control of mosquitoes. Dr. K. Murugan organized National and International Conferences at the Bharathiar University and disseminated the Scientific Information to the Scientists, farmer and public. Dr. K. Murugan’s recent research on the ecofriendly management of mosquito vectors by using plant chemicals which has not only mosquito larvicidal activity, it also possesses water purifications properties that has been proved to synergise with copepod for the control of dengue water in stored water ecosystem. Proposer: Prof. R. Ramamurthi, Seconder: Prof.G. Marimuthu Ten Best Publications: 1. Murugan K and Ancy George. (1992): Feeding and Nutritional Influence on Growth and Reproduction of Daphnis nerii (Linn.) (Lepidoptera: Sphingidae) J. Insect Physiol. (Great Britain) 38: 961-967 (if=2.236, ci=21). 2. Vahitha R Venkatachalam M R Murugan K and Jebanesan A. (2002): Larvicidal efficacy of Pavonia zeylanica L. Acacia ferruginea D.C. against Culex quinquefasciatus Say. Bioresource Tech., 82, 203- 204 (if=4.365, ci=35). 3. Senthil Nathan, S., Kalaivani, K., Chung, P.G., Murugan, K., (2006): Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) (Insecta: Lepidoptera: Pyralidae).Chemosphere. 62 (8), 1388-1393 (if=3.155, ci=16). 4. Nathan SS, Kalaivani K, Murugan K. (2005): Effects of neem limonoids on the malaria vector, Anopheles stephensi Liston (Diptera: Culicidae). Acta Trop. 96(1):47-55 (if=2.262, ci=103). 5. Murugan, K. Murugan P., and Noortheen A. (2007): Larvicidal and Repellent potential of Albizzia amara and Ocimum basilicum against dengue vector, Dengue vector, Aedes aegypti Liston (Insecta: Diptera: Culicidae). Bioresource Technology.98 (1):198-201(if=4.365, ci=95). 6. Murugan K, Mahesh Kumar P, Kovendan K, Amerasan D, Subramaniam J, Hwang JS. (2012): Larvicidal, pupicidal, repellent and adulticidal activity of Citrus sinensis Orange peel extract against Anopehles stephensi, Aedes aegyptiand Culex quinquefasciatus (Diptera: Culicidae) Parasitology Research. 111:1757-1769 (if=2.852, ci=30). 7. Devakumar Dinesh, Kadarkarai Murugan, Pari Madhiyazhagan, Chellasamy Panneerselvam, Palanisamy Mahesh Kumar, Marcello Nicoletti, Wei Jiang, Giovanni Benelli, Balamurugan Chandramohan, Udaiyan Suresh (2015): Mosquitocidal and antibacterial activity of green-synthesized silver nanoparticles from Aloe vera extracts: towards an effective tool against the malaria vector Anopheles stephensi? Parasitol Res DOI 10.1007/s00436-015-4336-z (if=2.33, ci=1). 8. Barnard DR, Dickerson CZ, Murugan K, Xue RD, Kline DL, Bernier UR (2014): Measurement of landing mosquito density on humans. Acta Trop 136:58-67 (if=2.519, ci=0). 9. Suresh U, Murugan K, Benelli G, Nicoletti M, Barnard DR, Panneerselvam C, Mahesh Kumar P, Subramaniam J, Dinesh D, Chandramohan B (2015): Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae). Parasitol ResDOI 10.1007/s00436-015-4339-9(if=2.33, ci=1). 10. Benelli G, Murugan K, Panneerselvam C, Madhiyazhagan P, Conti B, Nicoletti M (2015): Old ingredients for a new recipe? Neem cake, a low-cost botanical by-product in the fight against mosquito- borne diseases. Parasitol Res 114:391-397 (ci=1).

334

KAR, DEVASHISH (b 1954), Professor, Assam University, Silchar , Assam

Member of the NASI: No (YON 2013, Animal Sciences)

Professor Devashish Kar,(Ex Dean) reported:343 fish species;Causes of EUS fish disease;Advanced fry of Hilsa in wetlands.PI of Projects:NATP-ICAR,Inventory, Fishes;DBT,EUS Fish Disease’; UGC,Zooplankton;MOEF,GIS Habitat Mapping Mahseer Fishes, NEEPCO,‘Feasibility Studies Fisheries in Tipaimukh HE project;ICAR,‘GIS Habitat Mapping of Mahseer’.As Convener,National Symposia:(a)Wetlands,Fisheries; (b) Habitat mapping;(c)Ornamental Fishes, MPEDA;(d)International on Biodiversity; (e)International on Wetlands,Fisheries;(f)UGC Refresher courses;(g) Fishermen meets for UGC,NAAC teams.(i)Worked with Professor Madhav Gadgil,IISc on BSP (USA) project;(ii)PI of WWF- India BHCP works; (iii) Co-ordinated GB Pant IHED- Project. Was in King’s College, London as British Council Study Fellow. Presented his:(a) EUS researches, Gordon Conference , USA; (b) GIS-based paper at International Symposium on GIS in Fisheries,UK. He is a:Scientific Fellows,(i)Zoological Society and Linnean Society of London.(ii)Biotechnology National Associateship award, DBT. Felicitated and awarded:(i)All India Congress of Zoology;(ii) Diamond Jubilee of CIFRI;(iii)Dutta Munshi Award Fellow and Life Member of ISCA, ISNA,The Zoological Society,Calcutta, and India Key note addresses,chairing,many National and International Symposia,India and abroad. About 42 years of Research and Teaching . 301 research papers. Authors of many books, Including (a)Wetlands and Lakes of the World:by Springer (Germany) (2013); (b)EUS Fish Disease by Elsevier(USA)(2015). Proposer: Prof. Hemanta Kumar Majumder, Seconder: Prof. K. Muralidhar Ten Best Publications: 1. Binky, K., M. Shomorendra and Devashish Kar (2011): Nematode Parasites of Karbhala Wetland in Silchar Assam. Biological Forum . (An International Journal), 3(2): 18-21. (if=2.9, ci=16). 2. Das, U. and Kar, D. (2013): A Comparative Study On Qualitative And Quantitative Analysis Of Zooplankton In Relationship With Physico-Chemical Properties Of Water Between Karbala Lake And Baram Baba Pond Of Cachar District, Assam. International Journal (if=7.086, ci=26). 3. Das, P. and Kar, D. (2013): Studies on zooplankton diversity and physico-chemical parameters of Ramnagar annua, Assam. International Journal of Current Research. Volume 5 . pp 3058-3062. (if=7.086, ci=30). 4. Singh, N.R. and Kar, D. (2014): Abundance and Distribution of Helminth Parasites in the Fishes of Sone Beel, the biggest wetland in Assam. International Journal of Scientific Research, 3 (12) : 67-69. (if=4.176, ci=20). 5. Das, S.; Das,T.; Das, B.K.; and Kar, D.(2015): Study of fish diversity and physico-chemical characteristics of River Singla. International Journal of Environmental Sciences, 5 (6): 881-887 (ISSN 0976-4402). (if=4.69, ci=14). 6. Das, B. K.; Boruah, P. and Kar, D. (2014): Potential Application of Geographic Information System (GIS) and Remote Sensing (RS) in River Analysis. International Journal of Recent Scientific Research. (if=5.971, ci=20). 7. Das B.K., Kar D. (2015): Habitat Inventory Parameters and Drainage Analysis of River Siang in Arunachal Pradesh. International Journal of Marine Science 2015, Vol.5, No.48: 1-7. (if=1.543, ci=24). 8. Das, S.; Das, B.K.; and, Kar, D. (2015): Length-weight relationship and relative condition factor in Xenentodon cancila of River Mat in Mizoram. International Journal of Biology and Biological Sciences (ISSN 2327-3062), 4 (2): 027-031. (if=2.699, ci=29). 9. Singha, Minakshi; Shakuntala, I. and D. (2016): (Submitted). Prevalence of antimicrobial resistant Escherichia coli strains isolated from poultry , Meghalaya, India. International J of Current Res, 8 (7): 34688-34691. (if=7.086, ci=12). 10. Das, B. K., Dutta, B., Kar, S., Boruah, P. and Kar, D.(2013): Ichthyofauna of Subansiri River in Assam and Arunachal Pradesh, India. International Journal of Current Research. Pp 3314-3317. (if=7.086, ci=16).

335

SAVARIAR, VINCENT (b 1961), Dean of Research, Loyola College, Chennai

Member of the NASI: Yes (YON 2013, Animal Sciences)

Dr.S.Vincent has made commendable achievements in the field of Applied and Environmental Zoology. He has developed a novel biophysical method for determining the metal toxicity to aquatic fauna based on the electrical conductivity of proteins. He is one among the few scientists working on metallotheionins, and he developed computational programs, “Gprimer” and “ID3 algorithm” to identify and characterize various metallothionein genes and proteins respectively. He has also developed novel nanotherapeutic and theranostic strategies against pathogenic microbes and cancer cells, respectively. To reduce the morbidity of chronic ulcers, he developed economically viable novel collagen and phytoconstituents based therapeutic wound healing products (Patent Application: 2456/CHE/2015). Health promoting drink formulations with essential functional nutrients that he developed can provide instant energy as well as addressing the problems of malnutrition especially women and children (Patent Application: 533/CHE/2014). He has designed and implemented GIS strategy for the management of storm water drain in relevance to public health issues in urban cities for the first time to combat vector borne diseases. He has also contributed an Integrated online prediction system for disaster and disease outbreaks in controlling diseases and managing disasters. He has >90 peer reviewed publications with H Index of 18. His concepts secured several projects from government agencies. Proposer: Prof. Rallapalli Ramamurthi, Seconder: Prof. Kuruppacharil Varkey Peter Ten Best Publications: 1. Vivek R, Thangam R, Rajesh Kumar S, Rejeeth C, Sivasubramanian S, Vincent S, Gopi D and Kannan S (2016): HER2 Targeted Breast Cancer Therapy with Switchable “Off/On” Multifunctional Magnetic Polymer Core-Shell Nanocomposites. ACS Applied Materials (if=6.723, ci=4). 2. Arokiyaraj, S., Arasu, M. V., Vincent, S., Prakash, N. U., Choi, S. H., Oh, Y. K.& Kim, K. H. (2014): Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L and its antibacterial and cytotoxic effects: an in vitro study. (if=4.38, ci=46). 3. Arokiyaraj S, Dineshkumar V, Elakya V, Tamilselvan K, Park SK, Ragam M, Saravanan M, Bououdina M, Valan Arasu M, Kovendan K, Vincent S (2015): Biosynthesized silver nanoparticles using floral extract of Chrysanthemum indicum L.-potential for malar (if=2.828, ci=8). 4. Sridharan Brindha, Jagadish Chandrabose Sundaramurthi, Devadasan Velmurugan, Savariar Vincent, John Joel Gnanadoss (2016): Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. Bioinf (if=2.46, ci=-). 5. Arokiyaraj S, Saravanan M, Prakash NKU, Arasu MV, Vijayakumar B, Vincent S (2013): Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: An in vitro study. Mat Res Bull 48(9): 3323-3327 (if=2.288, ci=29). 6. Kovendan K, Murugan K, Vincent S (2012): Evaluation of larvicidal activity of Acalypha alnifolia Klein ex Wild. (Euphorbiaceae) leaf extract against the malarial vector, Anopheles stephensi, dengue vector, Aedes aegypti and Bancroftian filariasis v (if=2.098, ci=60). 7. Kovendan K, Murugan K, Vincent S, Kamalakannan S (2011): Larvicidal efficacy of Jatropha curcas and bacterial insecticide, Bacillus thuringiensis, against lymphatic filarial vector, Culex quinquefasciatus Say (Diptera:Culicidae) Parasitol Res 109:1 (if=2.098, ci=61). 8. Kovendan K, Murugan K, Vincent S, Barnard DR (2012): Studies on larvicidal and pupicidal activity of Leucas aspera Willd. (Lamiaceae) and bacterial insecticide, Bacillus sphaericus, against malarial vector, Anopheles stephensi Liston. (Diptera:Culi (if=2.098, ci=57). 9. Kovendan K, Murugan K, Kumar AN, Vincent S, Hwang JS (2012): Bioefficacy of larvicidal and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Cul (if=2.098, ci=42). 10. Kovendan K, Murugan K, Panneerselvam C, Mahesh Kumar P, Amerasan D, Subramaniam J, Vincent S, Barnard DR (2011): Laboratory and field evaluation of medicinal plant extracts against filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae). P (if=2.098, ci=28).

336

SHARMA, VIJAY KUMAR (b 1967), Professor, Chronobiology Lab Evolutionary and Organismal biology Unit,Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore Member of the NASI: No (YON 2013, Animal Sciences)

The nominee is among a handful of scientists worldwide who use an integrated approach to address questions in animal behaviour, ecology, sociobiology and evolution, and is presently the leading chronobiologist in India. He has contributed significantly towards our understanding of: (i) How social ants use circadian clocks to manage ‘division of labor’ (ii) Adaptive significance of circadian clocks, (iii) Rhythmic behaviours outside of the lab in semi-natural settings, (iv) Neurogenetic bases of egg-laying rhythm in Drosophila, (v) Role of circadian clocks in the regulation of life-history traits, (vi) Role of olfactory receptor 47b in the regulation of ‘nocturnal sex drive’ and ‘male-mating success’ and (vii) Role of social and mechanosensory stimulations in improving sleep. Through a series of long-term selection studies he raised populations of Drosophila that emerge in the morning (early) and evening (late) and have evolved behavioural and molecular clockwork considerably different from the controls. He has shown that genes mediating timing of emergence are primarily autosomal and involve additive, epistatic and pleiotropic interactions, and that several life-history traits also evolve as a correlated response to selection for morning and evening emergence. His studies showed that circadian clock-control of egg- laying rhythm in Drosophila lies outside of the canonical circadian pacemaker neurons. In recent studies, he has shown that the olfactory receptor Or47b is involved in the regulation of ‘nocturnal sex drive’ and male-mating success’ in Drosophila. Recently he showed that the afternoon-activity peak of Drosophila is independent of circadian clocks. Proposer: Prof Mewa Singh, Seconder:Prof. Ten Best Publications: 1. Padiath, Q. S., Paranjpe, D., Jain S., and V. K. Sharma. (2004): Glycogen Synthase Kinase 3b as a likely target for the action of lithium on circadian clocks. Chronobiology International 21:43-55. (if=4.1, ci=46). 2. Paranjpe, D. A., Anitha, D., Chandrashekaran, M.K., Joshi, A., and V. K. Sharma. (2005): Possible role of emergence rhythm in mediating the effect of light-dark environments on pre-adult development in Drosophila melanogaster. BMC Developmental Biology 5:5.(if=2.8, ci=28). 3. Ruoff, P., Christensen, M.K., and V. K. Sharma. (2005): PER/TIM-mediated Amplification, Gene Dosage Effects and Temperature Compensation in the Two-Loop-Model of the Drosophila Circadian Clock. Journal of Theoretical Biology 237: 42-57. (if=2.5, ci=44). 4. Sheeba, V., Chandrashekaran, M. K., Joshi, A. and V. K. Sharma. (2001): Persistence of oviposition rhythm in individuals of Drosophila melanogaster reared in an aperiodic environment for several hundred generations. Journal of Experimental Zoology 290:541-549. (if=2.5, ci=25). 5. Sharma, V. K., Lone, S.R., Goel A., Deepa, M., and M. K. Chandrashekaran. (2004): Circadian consequences of a social organization in the ant species Camponotus compressus. Naturwissenschaften 91:386-390. (if=2.5, ci=29). 6. Howlader, G., Paranjpe, D. A., V. K. Sharma. (2006): Non-ventral lateral neuron based non-PDF mediated clocks control circadian egg-laying rhythm in Drosophila melanogaster. Journal of Biological Rhythms 21:13-20. (if=3, ci=21). 7. Kumar, S., Kumar, D., Paranjpe, D. A., Akarsh, C. R., V. K. Sharma. (2007): Selection on the timing of adult emergence results in altered circadian clocks in fruit flies Drosophila melanogaster. Journal of Experimental Biology 210:906-918. (if=3, ci=12). 8. Sheeba, V., Fogle, K. J., Kaneko, M., Rashid, S., Chou, Y. T., Sharma, V. K., and T. C. Holmes. (2008): Large ventral lateral neurons modulate arousal and sleep in Drosophila. Current Biology 18:1537- 1545. (if=11, ci=118). 9. Lone, S. R. and V. K. Sharma. (2012): Or47b receptor neurons mediate socio-sexual interactions in fruit flies Drosophila melanogaster. Journal of Biological Rhythms 27:107-116. (if=3, ci=10). 10. De, J., Varma, V., Saha, S., Sheeba, V. and V. K. Sharma.( 2013): Significance of activity peaks in fruit flies, Drosophila melanogaster, under seminatural conditions. Proceedings of National Academy of Sciences USA 110:8984-8999. (if=9.8, ci=20).

337

SWARUP, ANOOP (b 1959), Vice Chancellor, Jagran Lakecity University, Bhopal

Member of the NASI: No (YON 2013, Animal Sciences)

Dr Anoop Swarup PhD, MSc (Zoology and Immunology), MPhil (Environmental Science) has a brilliant academic record being recipient of University Gold Medals and over 32 years of extensive and diverse experience as a scientist and an academic having also worked as Vice Chancellor of Shobhit University in 2008 and the founding Vice Chancellor of Jagran Lakecity University in 2012. A Fulbright Fellow to US, he was earlier National Science Talent Scholar, JRF with UGC and SRF with CSIR in 1981, had undertaken pioneering research to develop an effector mechanism for tumor specific immunity and delayed hypersensitivity in experimentally induced carcinoma and followed his work with researches on abnormal human hemoglobin proteins and the effect of radiation on lymphocytes under pathological conditions. His work on analysis of systems and interpretation of a hypothetical model of existence has been cited as a unique and multidisciplinary research on human interaction with the ecosystem, opening the field of anthropogenesis and futuristic studies on life sciences and the environment from the perspective of human conflicts, political ecology and development economics. Recipient of India’s Presidential Award, he undertook comprehensive climate change peer review as Global Environment Outlook Reviewer working with IPCC, UNEP that was awarded the Nobel Prize in 2007. A resource person with Linnaean Society, British Natural History Museum, WIPO, UNEP, WII, WWF, Lancaster University and Monash University. He is Chief Editor ‘International Journal of Contemporary Research in Engineering and Technology’ and Patron of ‘Nice Journal of Business’, has authored many books and research publications. Proposer : Prof. D. K. Belsare, Seconder : Prof. P. D. Prasad Rao Ten Best Publications: 1. Anoop Swarup (2012):“Stomach Specific Drug Delivery Systems.Brief Review”, Inventi spreading knowledge. Invent Rapid: NDDS , Issue 3, ISSN 0976-3791 (IF=2.84, CI=3). 2. P. Bhardwaj, R. Singh, A. Swarup (2012):“Development and In-Vitro evaluation of Floating Microspheres of 5-Flurouracil” International Journal Pharmaceutical Sciences and Research, IPJSR Vol3,Issue03, ISSN:0975-8232 (IF=4.57, CI=5.07). 3. Anoop Swarup, (2007): Contributor and Peer Review"Global Environment Outlook GEO4 (Environment for Development)", Environment Programme, ISBN: 978-92-807-2836-1 (UNEP paperback); 978-92-807-2872-9 (UNEP hardback). 4. Munish Sabharwal,Anoop Swarup (2012):“The Implementation of Disaster Management by Indian Banks – International Journal on Arts, Management and Humanities” 1(1): 73-80 (2012) ISSN (Online): 2319-5231. 5. Anoop Swarup (2012):“Human alpha-synuclein mutant A53T over-expression increases intracellular reactive oxygen species levels and modulates mitochondrial functions”, Conference on Next-Generation Sequencing, 18th Sept 2012, EMB-EBI, London. 6. Ram Upendra Das, Piyadasa Edirisuriya , Anoop Swarup (2009): "Regional Economic Engagements And Free Trade Agreements: Analytical Insights and Policy Options" World Scientific, Singapore, (2009); ISBN: 13 978-981-283-915-2. 7. Anoop Swaroop,Munish Sabharwal (2012):"Banking by the use of handheld devices & gadgets like Smart-phones, Tablets (Using Banking Applications & Widgets that are Based on Mobile Operating Systems like Android etc), International Journal on Emerging Technologies 3(2): 61-66(2012), ISSN (Print): 0975-8364, ISSN (Online): 2249-3255. 8. Anoop Swarup,Munish Sabharwal (2011):“Wireless MAN, mbwa (Mobile Broadband wireless access) and Wireless RAN (Regional Area Network)”: IEEE 802.16, IEEE 802.20 and IEEE 802.22. 9. Anoop Swarup (2011):"Principles & Perspectives in Biotechnology, KEPM (2011); ISBN: 978-81-8283- 148-3. 10. Anoop Swarup (2012):"Bio Innovations and Entrepreneurship", KEPM (2012);ISBN: 978-81-8283- 123-0.

338

WUDAYAGIRI, RAJENDRA (b 1955), Professor of Zoology, Former Vice-Chancellor, Sri Venkateswara University, Tirupati, A.P.

Member of the NASI: No (YON 2013, Animal Sciences)

Dr. W. Rajendra, Professor of Zoology, Sri Venkateswara University, Tirupati is a dedicated researcher and illustrious guide throughout his career. Prof. Rajendra’s unique contribution lies on the characterization of Lepidopteran-selective toxin (Buthus tamulus insect toxin; ButaIT) from the venom of Mesobuthus tamulus which was found to induce flaccid paralysis in Heliothis virescens. This toxin is a single polypeptide comprising 37 amino acids cross-linked by four disulfide bridges with a short α-helix and three antiparallel β-strands. Realizing the potential of this peptide toxin, as an alternative to the synthetic insecticides, he constructed a recombinant baculovirus (Autographa californica NPV) expressing Buta-IT that can be used as a biopesticide for effective control of Lepidopteran insect pests which otherwise are resistant to most of the known synthetic insecticides. Hence, his basic research has given an important dimension for fruitful applications. He made significant contributions towards understanding the therapeutic role of indigenous medicinal plants during selected neurological disorders such as Epilepsy, Parkinson’s and Alzheimer’s diseases. He also carried out investigations on the protective role of selected medicinal plants against induced liver damage. He has also contributed in the understanding of neurobiological aspects of Newcastle disease virus infection in poultry and suggested therapeutic measures in amelioration of NDV infection. In addition, the nominee has proposed potential applications of ion-channel peptide toxins as lead structures for the development of drugs for the treatment of wide variety of neurological disorders. Apart from these, Dr. Rajendra made significant contributions in the fields of pharmacology, toxicology, muscle physiology and ethnopharmacology. Proposer: Prof. T. Subramoniam, Seconder: Prof. S. Dayananda Ten Best Publications: 1. Rajendra, W., Bora Inceoglu, Rafael Herrmann, Maher Derbel, Prabhakar, V. Choudary, and Bruce D. Hammock. (2001): “Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tam (if=1.290, ci=51). 2. Rajendra, W., Kevin J. Hackett, Ellen Buckley and Bruce D. Hammock. (2006): “Functional expression of Lepidopteran-selective neurotoxin in baculovirus: Potential for effective pest management”., Biochimica et Biophysica Acta. 1760 (2): 158-163 (if=5.083, ci=35). 3. Rajendra, W., Armugam, A., Jeyaseelan, K. (2004):“Neuroprotection and Peptide toxins”., Brain Research Reviews., 45 (2): 125-141 (if=5.93, ci=29). 4. Rajendra, W., Armugam, A., Jeyaseelan, K. (2004): “Toxins in Anti-nociception and Anti-inflammation”. Toxicon., 44 (1): 1-17 (if=2.309, ci=69). 5. Banister, E.W., Rajendra, W. and Mutch, B.J.C. (1985): “Ammonia as an indicator of exercise stress: Implications of recent findings to sports medicine”., Sports Medicine., 2: 34 46. (if=5.579, ci=69). 6. Sahitya Chetan, P., Shanmugam, R.K., Sangeetha Lakshmi, R., Pavan Nagavenkata, K., Saritha, P., Murali Mohan, P., Rajendra, W. (2012): “Alterations in antioxidant enzyme activities and oxidative damage in alcoholic rat tissues: Protective role of (if=4.052, ci=19). 7. Venkatasubbiah, K.C., Lokanatha, V., Rajendra, W., Ramamurthy, C., Thirunavukkarusu, C. and Subramanyam, R. (2015): Newcastle disease virus (NDV) induces protein oxidation and nitration in brain and liver of chicken: Ameliorative effect of Vitamin (if=3.905, ci=1). 8. Mallikarjuna, K., Chetan, P.S., Sathyavelu Reddy, K. and Rajendra, W. (2008):“Ethanol Toxicity: Rehabilitation of Hepatic Antioxidant defense system with dietary ginger” Fitoterapia., 79: 174-178. (if=2.408, ci=52). 9. Muni Chandra Babu, T., Rammohan, A., Vijaya Bhaskar. B., Devi, S., Gunasekar, D., Rajendra, W. (2016): “Development of novel HER2 inhibitors against gastric cancer derived from falvonoid source of Syzygium alternifolium through molecular dynamics. Drug Des Devel Ther. 2016; 10: 3611–3632. (if=2.88). 10. Vijaya Bhaskar, B., Munichandra Babu, T., Vasudeva Reddy, N. and Rajendra, W., (2016): Homology modeling, molecular dynamics and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus.Drug Design, Development and Therapy 2016:10 3237–3252.

339

MEDICAL & FORENSIC SCIENCES (Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human genetics, Reproduction Biology, Neurosciences, Molecular Medicine)

BAJPAI, MINU (b 1958), Professor, Dept. Of Paediatric Surgery, All India Institute Of Medical Sciences, New Delhi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Prof. Bajpai has applied molecular studies to clinical research focused on renal diseases affecting children. Although 40-50% hydronephrosis diagnosed antenatally are due to pelviureteric junction obstruction, yet, there is no consensus on defining obstruction and on the optimal management of these patients. His observations have led to early identification of children whose kidneys could be salvaged by early surgery. Earlier, to his studies, persistence with antibiotics led to continued kidney injury. Thus this molecule serves as the critical discriminatory factor between patients who would benefit from medical versus surgical treatment. He has identified Plasma Renin Activity (PRA) as an early marker for inception of renal damage with respect to management and prognosis of Reflux Nephropathy. His publications formed the basis for recognition of this activated molecule even during foetal stage by the Obstetricians in Europe & several centres in the USA, such as-Johns Hopkins Institute, Baltimore & Stanford as well his ongoing studies in India. The details of this work are available in 3 Global First reports he which he has published. Prof. Bajpai has also established a relationship between alterations in Renin Angiotensin System, Genetic polymorphism for Angiotensin converting enzyme and Progressive disease in Indian children. His report is the first on Indian Children that ‘D’ allele may be one of the genetic susceptibility factors contributing to adverse renal prognosis in patients with congenital uropathies. The usefulness of genotype extends beyond prognostication & to identification of patients who may benefit from angiotensin converting enzyme inhibitors and angiotensin II antagonists. Proposer: Prof. Chitra Sarkar, Seconder: Prof. Sanjeev Sinha Ten Best Publications: 1. Gupta DK, Srinivas M, Dave S, Agarwala S, Bajpai M, Mitra DK. Gastric teratoma in children. Pediatric surgery international. 2000: 16(05-Jun); 329-332. (if=1.01, ci=34) 2. Bajpai M, Chandrasekharam VVSS. Nonoperative management of neonatal moderate to severe bilateral hydronephrosis. The Journal of urology. 2002: 167(2); 662-665 (if=4.471, ci=28) 3. Bajpai M, Dave S, Gupta DK. Factors affecting outcome in the management of posterior urethral valves. Pediatric surgery international. 2001: 17(1); Nov-15. (if=1.01, ci=28) 4. Bajpai M, Mathur M. Duplications of the alimentary tract: clues to the missing links. Journal of pediatric surgery. 1994: 29(10); 1361-1365. (if=1.733, ci=27) 5. Bajpai M, Pal K. Aplasia cutis cerebri with partial acrania-Total reconstruction in a severe case and review of the literature. Journal of pediatric surgery. 2003: 38(2); E4. (if=1.733, ci=20) 6. Bajpai, Minu, Das, K, Gupta, Arun K, Caudal duplication syndrome: more evidence for theory of caudal twinning. Journal of pediatric surgery. 2004: 39(2); 223-225. (if=1.733, ci=19) 7. Bajpai M, Puri A, Tripathi M, Maini A. Prognostic significance of captopril renography for managing congenital unilateral hydronephrosis. The Journal of urology. 2002: 168(5); 2158-2161. (if=4.471, ci=17) 8. Yadav C, Bajpai M, Kumar V, Ahmed RS, Gupta P, Banerjee BD. Polymorphism in CYP1A1, GSTM 1, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Human & experimental toxicology. 2011 Oct; 30(10): 1464-74. (if=1.747, ci=15) 9. Bajpai M, Kumar A, Tripathi M, Bal CS., June 2004, Dorsal lumbotomy incision in paediatric pyeloplasty. ANZ J Surg., 74 (6): 491-4. (if=1.158, ci=15) 10. Puri A, Bajpai M. Gastroschisis and omphalocele. The Indian Journal of Pediatrics. 1999: 66(5); 773- 789. (if=0.808, ci=12)

340

BAL, CHANDRA SEKHAR (b 1960), Professor & Head, Department of Nuclear Medicine, AIIMS, New Delhi 110029

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr Chandrasekhar Bal who works as Professor and Head of the Department of Nuclear Medicine at All India Institute of Medical Sciences, New Delhi has made outstanding contributions in the field of Nuclear Medicine. His overall impact is very strong in the practice of nuclear medicine, teaching and research. Dr Bal has started DM Programme in Therapeutic Nuclear Medicine at AIIMS, New Delhi for the first time in the World. This programme is envisaged as path-breaking in radionuclide therapy and shall encourage many youngsters to choose a career dedicated to further develop the radionuclide Therapy in India that is now available only in a few metropolitan cities. On the basis of his contributions in the field of Thyroid Cancer Research, two recommendations have been changed in the American Thyroid Association (ATA2015) Guidelines on Thyroid Cancer: one on “Low-dose Radioiodine Ablation” and other one is on “Lobar Ablation”. In order to fulfil the man-power needs of the country, Dr Bal was instrumental in starting MD (Nuclear Medicine) at AIIMS in 1996, MSc (Nuclear Medicine Technology) in 2003 and DM in 2015. The PhD programme of the department is at full swing, currently where 4 students are enrolled under his guidance. He has made a large number of publications with 390 papers in peer reviewed journals with total citations of 3910. His current h-index is 31 and i10-index is 120. He has introduced peptide-based radionuclide PET imaging and therapy in India. This being practiced in many institutions and hospitals in the country. Proposer: Prof. T P Singh, Seconder: Prof. Chitra Sarkar Ten Best Publications: 1. C Bal, AK Padhy, S Jana, GS Pant, AK Basu 1996 Prospective randomized clinical trial to evaluate the optimal dose of 131I for remnant ablation in patients with differentiated thyroid carcinoma. Cancer 77(12); 2574-2580. Impact Factor of CANCER: 5 (if=CANCER: 5.649, ci=Google Scholar 192; Web of Science 101) 2. CS Bal, A Kumar, GS Pant 2004 Radioiodine dose for remnant ablation in differentiated thyroid carcinoma: a randomized clinical trial in 509 patients. The Journal of Clinical Endocrinology & Metabolism 89(4); 1666-1673. (if=JCEM: 6.206 , ci=Google Scholar 175; Web of Science 86) 3. NK Gowda, D Agrawal, C Bal 2006 Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. Am J Neuroradiology 27(2); 447-451 (if=AJNR: 3.124, ci=Google Scholar 92; Web of Science 52) 4. R Goswami, CS Bal, S Tejaswi, GV Punjabi, A Kapil, N Kochupillai 2001 Prevalence of urinary tract infection and renal scars in patients with diabetes mellitus. Diabetic Research and Clinical Practice 53(3); 181-186 (if=DRCP: 3.045, ci=Google Scholar 91; Web of Science 23) 5. CS Bal, A Kumar, RM Pandey 2002 A randomized controlled trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyroidism. Thyroid 12(5); 399-405. (if=THYROID”: 4. 493, ci=Google Scholar 83; Web of Science 31) 6. JA Sosa, R EElisei, B Jarzab, J Balkissan, S Lu, C Bal, S Marur, A Gamza 2014 Randomized safety and efficacy study of fosbretabulin with paclitaxel/carboplatin against anaplastic thyroid carcinoma. Thyroid 24(2)-232-240. (if=“THYROID”: 4. 493, ci=Google Scholar 55; Web of Science 35) 7. CS Bal, A Kumar, P Chandra, SN Dwivedi 2004 Is chest x-ray or high-resolution computed tomography scan of the chest sufficient investigation to detect pulmonary metastasis in pediatric differentiated thyroid cancer. Thyroid 14(3); 217-225 (if= “THYROID”: 4. 493, ci=Google Scholar 54; Web of Science 22) 8. N Naswa, P Sharma, R Kumar, S Chumber, C Bal 2011 Gallium-68-DOTA-NOC PET/CT of patients with gastroenteropancreatic neuroendocrine tumors: a prospective single-center study. Am J Rontgenology. Am J Rontgenology 197; 1221-1228 (if= “AJR” : 2. 775, ci=Google Scholar 71; Web of Science 43) 9. A Kumar, DN Srivastava, TTM Chau, HD Long, CS Bal 2007 Inoperable Hepatocellular Carcinoma: Transarterial 188Re HDD–Labeled Iodized Oil for Treatment —Prospective Multicenter Clinical Trial. Radiology 243(2); 509-519. (if=“Radiology” : 6.867, ci=Google Scholar 50; Web of Science 25) 10. Bal C, Kumar A Tripathi M, Chandrashekar N, Phom H, Murli NR, Prem Chandra, Pant GS 2005 High-dose radioiodine treatment for differentiated thyroid carcinoma is not associated with change in female fertility or any genetic risk to the offspring. (if=Red Journal: 4.258, ci=Google Scholar 40; Web of Science 20)

341

BANERJEE, SOMA (b 1970), Associate Professor and Institute of Post graduate Medical Education and Research, Kolkata

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

The focus of Dr. Banerjee’s research is to understand the mechanism of non-coding RNA mediated regulation in the development and progression of hepatocellular carcinoma (HCC). She has classified several deregulated microRNAs in HCC and few miRNAs have been characterized as biomarker for early prediction of deadliest HCC. She has also identified and characterized a miRNA, which could reduce the expression of multiple growth factors and their receptors simultaneously and thus resist intercellular cross communication and signaling for growth and metastasis of HCC cells. Hence this miRNA possesses a robust therapeutic potential for HCC. Moreover, using next generation sequence analysis, role of several novel miRNAs in the development of HCC was also investigated to understand the disease pathogenesis. She has established the influence of genotypes/subgenotypes of hepatitis B virus and few accumulated mutations in the viral genome on the development of HCC. Few mutations have been recognized as early HCC markers. In addition, she has identified few single nucleotide polymorphisms in the promoter region of various upregulated immune genes, which have significant influence in disease biology of alcohol induced liver diseases (ALD) and complementary functional investigation showed their efficiency as predictor of ALD (3). A therapeutic microRNA has also been identified for ALD for the first time. Earlier she has generated a high-resolution physical map of the genome of severe diarrhoea causing bacteria Vibrio Cholerae, and it is useful for further genetic and translational study in this organism. She has also identified and characterized several novel tumor suppressor genes in cancer. Proposer: Dr. Susanta Roychowdhury, Seconder: Prof. Abhijit Chowdhury Ten Best Publications: 1. Ghosh A, Dasgupta D, Ghosh A, et al;2017. MiRNA199a-3p Suppresses Tumor Growth, Migration, Invasion and Angiogenesis in Hepatocellular Carcinoma by Targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2. Cell Death and Diseases. 8, e2706. (if=5.378, ci=nil) 2. Ghosh A, Ghosh A, Datta S, et al; 2016, Hepatic miR-126 is a Potential Plasma Biomarker for Detection of Hepatitis B Virus Infected Hepatocellular Carcinoma. International Journal of Cancer, Jun 1;138(11):2732-44. (if=5.53, ci=6) 3. Roy N, Dasgupta D, Mukhopadhyay I, et al; 2016. Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India. PLoS One. Mar 3;11(3):e0149843. (if=3.2, ci=nil) 4. Ghosh A, Ghosh S, Dasgupta D, et al; 2016. Hepatitis B Virus X Protein Upregulates hELG1/ A T AD5 Expression through E2F1 in Hepatocellular Carcinoma. International Journal of Biological Sciences 12(1): 41-52. (if=3.982, ci=nil) 5. Datta S, Ghosh A, Ghosh A, et al; 2014. Novel point and combo-mutations in the genome of hepatitisB virus genotype D: Characterization an impact on liver disease progression to hepatocellular carcinoma. PloS One; 9(10): e110012. (if=3.2, ci=4) 6. Datta S, Roychoudhury S, et al; 2014. Distinct distribution pattern of hepatitis B virus genotype C and D in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients. PLoS One. Jul 17; 9(7). :e102573. (if=3.2, ci=1) 7. Roy N, Mukhopadhyay I, Das K, et al;2012. Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population. Gene. Nov 1;509(1):178-88. (if=2.319, ci=4) 8. Henry JC, Park JK, Jiang J, et al; 2010. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. Dec 3;403(1):120-5. (if=2.297, ci=41) 9. Banerjee S, Smith S, Oum JH, et al; 2008. Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. J Cell Biol. Jun 30;181(7):1083-93. (if=9.893, ci=22) 10. Banerjee S, Smith S and Myung K. 2006. Suppression of Gross chromosomal Rearrangements by yKu70-yKu80 Heterodimer Through DNA damage checkpoints.. Proc Natl Acad Sci U S A, Feb 7; 103(6): 1816-1821. (if=9.423, ci=6)

342

BHUMA, VENGAMMA (b 1960), Senior preofessor ,Department of Neurology ,Sri Venkateswara Institute of Medical Sciences, Tirupati

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

 The nominee has contributed immensely to the starting of and development of Neurology as a specialty in the backward Rayalaseema area of and organization of care at community level for patients affected with epilepsy.  The nominee’s work was instrumental in documenting the management practices and utilization of various medical services for epilepsy in different parts of India and also annual economic burden of epilepsy in India.  Another pioneering venture undertaken by the nominee is organizing the care of epilepsy at a community level by initiating the “Monthly Free Epilepsy Camp” that is attended by more 450 patients every month where free antiepileptic medications are also given to patients. The successful uninterrupted run of this “Monthly Free Epilepsy Camp” for more than the last 13 years since 1999 incurring an expenditure of more than Rs 1 Crore is a testimony to the commitment, organization skills including financial and programmatic capability of Dr B. Vengamma.  She has also shown that in patients with intermediate syndrome due to organophosphorus compound poisoning, neuromuscular junctional dysfunction is the predominant factor for intermediate syndrome. Her research work has also established thatdisturbances in trace element homeostasis during the progression of Parkinson’s disease.  The nominee is recognized as a postgraduate teacher and guide for MD, DM MCh and PhD students for 43 students since 2003 Proposer: Dr. (Mrs) Asha Juwarkar, Seconder: Prof. U.C. Srivatsava Ten Best Publications: 1. Shailesh KK, Pais P, VengammaB, Muthane U. Clinical and electrophysiological study of intermediate syndrome in patients with organophosphorous poisoning. J Assoc Physicians India 1994;42:451-3 (if=Impact Factor 0.37, ci=Cited by 35) 2. Thomas SV, Sarma PS, Alexander M, Pandit L, Shekar L, Trivedi C, Vengamma B. Economic burden of epilepsy in India. Epilepsia 2001;42:1052-60 (if=. (Impact Factor 4.571), ci= Cited by 83) 3. Thomas SV, Sarma PS, Alexander M, Pandit L, Sekhar L, Trivedi C, Vengamma B. Epilepsy care in six Indian cities : a multicentre study on management and service. J Neurol Sci 2001;188:73-7 (if=. (Impact Factor 2.474) , ci=Cited by 26) 4. Hegde ML, Shanmugavelu P, Vengamma B, Rao TS, Menon RB, Rao RV, Rao KS. Serum trace element levels and the complexity of inter-element relations in patients with Parkinson’s disease. J Trace Elem Med Biol 2004;18:163-71 (if=(Impact Factor 2.550) , ci=Cited by 79) 5. Damodaram P, Manohar IC, Prabath Kumar D, Mohan A, Vengamma B, Rao MH. Myasthenic crisis- like syndrome due to Cleistanthuscollinus poisoning. Indian J Med Sci 2008;62:62-4 (if=(Impact Factor 0.62) , ci=Cited by 12) 6. Ramakrishna P,Naresh VVS, Chakrapani B, Vengamma B, Sivakumar V. Leptospirosis with acute renal failure and paraparesis. Indian J Nephrol 2008;18:130-1 (if= (Impact Factor 0.55 ) , ci=Cited by 8) 7. Ramakrishna P,Naresh VVS, Lakshmi AY, Vengamma B, Sivakumar V. Stroke in chronic kidney disease. Indian J Nephrol 2009;19:5-7(Impact Factor 0.55 ) (if=(Impact Factor 0.55 ) , ci=Cited by 8) 8. Munikumar M, Priyadarshini IV, Pradhan D, Umamaheswari A, Vengamma B. Computational approaches to identify common subunit vaccine candidates against bacterial meningitis. Inter discip Sci 2013;5:155-64 (if=(Impact factor0.853) , ci=Cited by 8) 9. Venkatesh K, Srikanth L, Vengamma B, Chandrasekhar C, Prasad BC, Sarma PV. In vitro transdifferentiation of human cultured CD34+ stem cells into oligodendrocyte precursors using thyroid hormones. Neurosci Lett 2015;588:36-41. (if=(Impact Factor 2.026) , ci=Cited by 6) 10. Sharma SK, Katoch VM, Mohan A, Kadhiravan T, Elavarasi A, Ragesh R, Nischal N, Sethi P, Behera D, Bhatia M, Ghoshal AG, Gothi D, Joshi J, Kanwar MS, Kharbanda OP, Kumar S, Mohapatra PR, Mallick BN, Mehta R, Prasad R, Sharma SC, Sikka K, Aggarwal S, S (if=(Impact Factor 1.446) , ci= Cited by 6)

343

CHAKRABARTI, SASANKA (b 1954), Professor & Head (Biochemistry) ICARE Institute of Medical Sciences and Research,Haldia, Purva Medinipur, WB

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

The nominee has been working in the area of brain aging and age-related neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD) for nearly two decades. He has demonstrated how mitochondrial impairment, synaptosomal changes, altered amyloid beta metabolism and learning and memory impairment in aging brain could be ameliorated by a combination of marketed drugs like N-acetylcysteine, α-lipoic acid, and α-tocopherol [Neurochem. Int. (2015) 95, 92-99, Exp. Gerontol. (2014) 50, 19-25]. These results have great translational value and could be potential remedies for age-associated brain deficit or even AD . His recent publication showing the beneficial effect of deferasirox, the iron-chelator used in thalassemia, in rescuing the age-dependent increase in β-amyloid production and accumulation in rat brain has also clear therapeutic implications in AD [J. Alzheimers Dis (2015) 49, 681-693.]. He has further shown in details how iron can alter amyloid beta homeostasis at multiple steps within SHSY5Y cells. In contrast to widely accepted view of amyloid β protein as toxic, he has shown in a detailed study a potential beneficial effect of amyloid beta protein [Free Radic. Biol. Med. 56,184-192] and interestingly several recent papers from other labs have also supported this. The nominee has also published several very interesting papers on the etiopathogenesis of Parkinson's disease showing the important role of dopamine oxidation products, α-synuclein and mitochondria in neural cell death [BBA (2011) 1812, 663-673, J.Neurochem. (2014) 131, 868-877.] Proposer: Prof. Mitali Chatterjee, Seconder: Prof. Mahendra Kumar Thakur Ten Best Publications: 1. Khan F.H., Sen T., Maiti A.K., Jana S., Chatterjee U., Chakrabarti S. (2005) Inhibition of rat brain mitochondrial transport chain activity by dopamine oxidation ...... for Parkinson’s Disease. Biochim Biophys Acta; 1741: 65-74 (if=5.15, ci=60) 2. Sen T., Sen N., Jana S., Khan F.H., Chatterjee U., Chakrabarti S. (2007) Depolarization and cardiolipin depletion in aged rat brain mitochondria: relationship with oxidative stress and electron transport chain activity. Neurochem. Int. 50, 719-725 (if=3.38, ci=56) 3. Banerjee K., Sinha M., Pham Lan C. L., Jana S., Chanda D., Cappai R., Chakrabarti S.(2010) α- Synuclein induced membrane depolarization and loss of phosphorylation capacity ...... in Parkinson’s disease. FEBS Lett. 584, 1571-1576 (if=3.51, ci=55) 4. Bagh M. B., Guha Thakurta I., Biswas M., Behera P., Chakrabarti S.(2011) Age related oxidative decline of mitochondrial functions in rat brain is prevented by long term oral antioxidant supplementation. Biogerontol. 12, 119-131 (if=3.25, ci=39) 5. Jana S, Sinha M, Chanda D, Roy T, Banerjee K, Munshi S, Patro BS, Chakrabarti S (2011). Mitochondrial dysfunction mediated by quinone oxidation products of ...... pathogenesis of Parkinson's disease. Biochim. Biophys. Acta 1812, 663-673 (if=5.15, ci=55) 6. Chattopadhyay M, Thakurta IG, Behera P, Ranjan KR, Khanna M, Mukhopadhyay S, Chakrabarti S (2011). Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus. Metabolism-Clinical and Experimental 60, 1702-1710 (if=4.37, ci=22) 7. Sinha M., Bhowmick P., Banerjee A., Chakrabarti S.;(2013) Antioxidant role of amyloid β protein in cell free and ...... for the pathogenesis of Alzheimer disease. Free Radic. Biol. Med. 56,184-192 (if=5.78, ci=15) 8. Khemka V K., Bagchi D., Bandyopadhyay K., Bir A., Chattopadhyay S., Chakrabarti S. (2014) Altered serum levels of adipokines and insulin in probable Alzheimer's disease. J. Alzheimers Dis. 41, 525-533 (if=3.92, ci=23) 9. Aritri Bir, Oishimaya Sen, Shruti Anand, Vineet Kumar Khemka, Priyanjalee Banerjee, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti (2014) α-Synuclein induced mitochondrial dysfunction in isolated preparation and intact cells :Implications in (if=3.84, ci=22) 10. Maitrayee Sinha, Aritri Bir, Anindita Banerjee, Pritha Bhowmick and Sasanka Chakrabarti (2015) Multiple mechanisms of age dependent accumulation of amyloid beta ...... N-acetylcysteine, α-lipoic acid and α-tocopherol. Neurochem. Int. 95, 92-99 (if=3.38, ci=4)

344

CHAUHAN, SHYAM SINGH (b 1958), Professor and Head, Department of Biochemistry, All India Institute of Medical Sciences, Anasri Nagar, New Delhi-110029

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Prof. Shyam S. Chauhan has made pioneering contribution in elucidating the role of cathepsin L in cancer biology. He for the first time demonstrated over expression of this lysosomal protease in human tumors (Cancer Res. 51: 1478-1481, 1991) and established the involvement of its carboxy terminus in its secretion by malignant cells (Biochemistry 37: 8584-8594, 1998) which formed the basis of establishing its role in tumorigenesis, invasion and metastasis. His laboratory identified novel splice variants of cathepsin L (Gene, 293: 123-131, 2002) and demonstrated their role in malignant transformation (Mol. Cancer Res. 5:899-907, 2007). His extensive work on regulation of cathepsin L gene expression and transcriptional upregulation of this protease by VEGF and , (Gene, 399: 129-136, 2007; Biol. Chem., 39: 1031-1040, 2010) unraveled another link between angiogenic, tumorigenic and metastatic factors with potential therapeutic utility. Cloning and localization of human cathepsin L gene on short arm of chromosome 9 (J. Biol.Chem. 268: 1039-1045, 1993) suggested its involvement in pathogenesis of CML. His group demonstrated the diagnostic and prognostic utility of cathepsin L in CML (J. Cell. Mol. Med. 15: 2189-2199, 2011). Similarly his findings demonstrated the prognostic utility of cathepsin L and B in AML (Ann. Hematol., 89: 1223-1232, 2010). Furthermore, his group has done extensive work on identification of markers for early diagnosis and poor prognosis of oral cancer (.J. Proteome Res.8: 300-309, 2009; Mod. Pathol. 25: 14-25, 2012; J. Transl. Med., 13: 8, 2015; Clin. Chim. Acta., 459:45-52,2016 ) Proposer: Prof. Anil K. Tyagi, Seconder: Prof. Chitra Sarkar Ten Best Publications: 1. Chauhan, S.S., Goldstein, L.J. and Gottesman, M.M.: (1991). Expression of cathepsin L in human tumors. Cancer Res. 51: 1478-1481. (if=9.33, ci=195) 2. Chauhan, S.S., Popescu, N., Ray, D., Flieschman, R., Gottesman, M.M. and Troen, B.R.: (1993). Cloning, genomic organization and chromosomal localization of human cathepsin L .J. Biol.Chem. 268: 1039-1045. (if=5.5, ci=99) 3. Arora, S. and Chauhan, S.S.: (2002). Identification and characterization of a novel human cathepsin L splice variant. Gene, 293: 123-131. (if=2.3, ci=44) 4. Keethivasan, S., Keethivasan G., Mittal, S. and Chauhan, S.S.: (2007). Transcriptional upregulation of human cathepsin L by VEGF in cells. Gene. 399: 129-136. (if=2.3, ci=27) 5. Goulet B, Sansregret L, Leduy L. Bogyo M.., Weber E, Chauhan S.S., Nepveu A. (2007). Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol Cancer Res. 5:899-907. (if=4.9, ci=9.5) 6. Ralhan, R., DeSouza, L.V., Matta, A., Tripathi, S.C., Ghanny, S., Dattagupta, S., Thakar, A., Chauhan, S.S. and Siu, K.W.M. (2009). iTRAQ-multidimentional liquid chromatography and tendem mass spectrometery based identification of potential biomar (if=4.17, ci=71) 7. Jain, M., Bakhshi, S., Shukla, A.A. and Chauhan, S.S.: (2010). Cathepsins B and L in peripheral blood mononuclear cells of pediatric acute myeloid leukemia: potential poor prognostic markers. Ann. Hematol., 89: 1223-1232. (if=3.2, ci=14) 8. Samaiya, M., Bakhshi, S., Shukla, A.A., Kumar, L and Chauhan S.S.: (2011). Epigenetic regulation of cathepsin L expression in chronic myeloid leukemia. J. Cell. Mol. Med. 15: 2189-2199. (if=4.8, ci=8) 9. Kumar, M., Srivastava, G., Kaur, J., Assi, J., Alyass, A., Leong, I., MacMillan, C., Witterick, I., Shukla, N.K., Thakar, A., Duggal, R., Roychoudhury, A., Sharma, M.C., Walfish, P.G., Chauhan, S.S. and Ralhan R.: (2015). Prognostic significance (if=3.92, ci=-) 10. Kumar, M., Mehra, S., Thakar, A., Shukla, N.K., Roychoudhary, A., Sharma, M.C., Ralhan, R. and Chauhan, S.S.: (2016) End Binding 1 (EB1) overexpression in oral lesions and cancer: A biomarker of tumor progression and poor prognosis. Clin. Chim. A (if=2.79)

345

CHIPLUNKAR, SHUBHADA VIVEK (b 1954), Director-Advanced Center for Treatment Research & Education in Cancer-ACTREC, Navi Mumbai

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Prof. S.V.Chiplunkar, Director, ACTREC is a well known Cancer Immunologist. Her research focusses on understanding immune dysfunctions in cancer patients and development of cell based therapy. She has done pioneering work in understanding the role of gamma delta T cells in tumor immunity. She demonstrated that these cells mediate anti-tumor cytotoxicity by recognition of heat shock proteins (hsp60/hsp70) expressed on oral/esophageal tumors and that patients with acute lymphoblastic leukemias with gamma delta TCR clonality have improved survival. She defined a novel mode of action of bisphosphonates through activation of gamma delta T cells which has relevance in understanding their role in breast cancer patients.Her group was the first to report the role of notch signaling in activation and effector functions of gamma delta T cells (Gogoi and Chiplunkar 2014). She showed that activated gamma delta T cells inhibit bone resorption and play an important role in controlling bone metastasis. A novel finding from her lab was that Tgamma delta17 subset contributes to tumor progression and angiogenesis. Her work have provided important leads in understanding basic gamma deltaT cell immunobiology and has important implications in cancer immunotherapy. She is currently studying the immuosuppressive networks in tumor microenvironment contributed by Regulatory T cells, MDSCs and mesenchymal stem cells. Her research work is internationally highly acclaimed. Proposer: Dr. Sharmila A Bapat, Seconder: Dr. Mohan R Wani Ten Best Publications: 1. Patil RS, Shah SU, Shrikhande SV, Goel M, Dikshit R, Chiplunkar SV. 2016. IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients. Int J Cancer. 139(4):869-81. doi: 10.1002/ijc.30134 (if=5.085, ci=2) 2. Dar AA, Pradhan TN, Kulkarni DP, Shah SU, Rao KV, Chaukar DA, D'Cruz AK, Chiplunkar SV. 2016. Extracellular 2'5'Oligoadenylate synthetase 2 (OAS2) mediates TCR CD3-ζ chain downregulation via caspase-3 activation in oral cancer. Immunology 147(2): (if=3.795 , ci=3) 3. Gogai D, Dar AA, Chiplunkar SV. 2014. Involvement of Notch in Activation and Effector Functions of gamma delta T cells. J Immunol. 192:2054-2062 (if=4.922 , ci=11) 4. Balakrishnan B, Indap MM, Singh SP, Krishna CM, Chiplunkar SV. 2014. Turbo methanol extract inhibits bone resorption through regulation of T cell function. Bone. 58:114-25. doi:10.1016/j.bone.2013.10.008 (if=3.973 , ci=4) 5. Patel S, Vetale S, Teli P, Mistry R, Chiplunkar SV. 2011. IL-10 production in non-small cell lung carcinoma patients is regulated by ERK P38 and COX2. J Cell Mol Med. 16(3):531-44. doi:10.1111/j.1582-4934.2011.01329.x (if=4.014 , ci=14) 6. Kulkarni D, Wadia P, Pradhan T, Pathak A, Chiplunkar SV. 2009. Mechanisms involved in the down- regulation of TCR  chain in tumor versus peripheral blood of oral cancer patients. Int J Cancer. 124(7):1605-1613. (if=5.085 , ci=21) 7. Atre N, Thomas L, Mistry R, Pathak K, Chiplunkar SV. 2006. Role of nitric oxide in heat shock protein induced apoptosis of  T cells. Int J Cancer. 119(6):1368-1376. (if=5.085 , ci=24) 8. Thomas MT, Badwe, RA, Deshpande, RK, Samant UC, Chipunkar SV. 2001. Role of adhesion molecules in recruitment of V 1 T cells from the peripheral blood to the tumor tissue of esophageal cancer patients. Cancer Immunol Immunother. 50(4):218-225 (if=3.941 , ci=20) 9. Thomas ML, Samant U, Deshpande RK, Chiplunkar SV. 2000. Gamma Delta T cells lyse autplogous and allogenic esophageal tumors: Involvement of heat shock proteins in the tumor cell lysis. Cancer Immunol Immunother. 48(11):653-659. (if=3.941 , ci=54) 10. Laad AD, Thomas LM, Fakih AR, Chiplunkar SV. 1999. Human  T cells recognize heat shock protein - 60 on Oral tumour cells. Int J Cancer. 80(5):709-714. (if=5.085 , ci=66)

346

CHOWDHURY, RUKHSANA (b 1958), Chief Scientist CSIR-Indian Institute of Chemical Biology, Kolkata

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr. Rukhsana Chowdhury has done pioneering work on enteric - Vibrio cholerae and Helicobacter pylori, for which she is known internationally. In a series of pathbreaking work, she was the first to show that bile affects production of choleratoxin (primarily responsible for the pathogenecity of V. cholerae) and also binding of choleratoxin to intestinal receptors (Infect. Immun. 2006, 74:3060-3064; Infect. Immun. 1997, 65:1131 – 1134). She also showed that bile induces expression of efflux pumps in V. cholerae resulting in pumping out noxious compounds allowing the bacteria to survive in the intestine (J. Bacteriol., 2004, 188:6809-6814). Another work that has attracted considerable attention is the demonstration that unsaturated fatty acids strongly inhibit production and activity of choleratoxin (Infect Immun. 2013, 81:3935-41; Infect Immun., 2011, 79:258-66). This opened up the possibility of a new approach for prevention and treatment of cholera, as it suggested that oral administration of unsaturated fatty acids could be used both as prophylactic and therapeutic agent (Antimicrob. Agents Chemother, 2008, 52:220-224; Infect. Immun., 2007, 75: 1946-1953). Her finding that V. cholerae forms biofilms not only for environmental persistence, as has hitherto been believed, but also upon contact with intestinal cells has generated great interest among cholera researchers because of immense clinical implications in cholera pathogenesis (J Infect Dis., 2016, 214:1571-1578). Her work on H. pylori has provided insights into host pathogen interactions and has identified bacterial risk factors for H. pylori induced gastric cancer (J Infect Dis., 2016, 214:196-204; J. Infect Dis., 2015, 211:1779-1789). Proposer: Dr. Amit Ghosh, Seconder: Dr. Chitra Mandal Ten Best Publications: 1. Gupta S. and R. Chowdhury. 1997 Bile affects production of virulence factors and motility of Vibrio cholerae. Infect. Immun. 65 : 1131 – 1134. (if=4.2, ci=148) 2. Chatterjee, A., S. Chaudhuri, G. Saha, S. Gupta, and R. Chowdhury. 2004 Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae. J. Bacteriol. 188: 6809-6814 (if=4.5, ci=50) 3. Chatterjee A., P.K. Dutta and R. Chowdhury. 2007. Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae Infect. Immun. 75: 1946-1953 (if=4.2, ci=86) 4. Chatterjee A and R. Chowdhury 2008 Bile and unsaturated fatty acids inhibit the binding of Cholera Toxin and Escherichia coli heat labile enterotoxin to GM1 receptor. Antimicrob. Agents Chemother 52: 220-224 (if=4.7, ci=6) 5. Ray S, Chatterjee E, Chatterjee A, Paul K, and R. Chowdhury. 2011 A fadD mutant of Vibrio cholerae is impaired in the production of virulence factors and membrane localization of the virulence regulatory protein TcpP. Infect Immun 79: 2 (if=4.2, ci=15) 6. Chatterjee E, Chowdhury R. 2013 Reduced Virulence of the Vibrio cholerae fadD Mutant Is Due to Induction of the Extracytoplasmic Stress Response Infect Immun. 81(10):3935-41 (if=4.16, ci=4) 7. Raghwan, Chowdhury R. 2014 Host cell contact induces Fur-dependent expression of virulence factors CagA and VacA in Helicobacter pylori. Helicobacter. 19:17-25. Selected as 'Faculty of 1000 Prime' (if=3.5, ci=8) 8. Baidya AK, Bhattacharya S, Chowdhury R. 2015 Role of the flagellar hook length control protein FliK and sigma-28 in cagA expression in gastric cell adhered Helicobacter pylori. J. Infect Dis 211:1779-89 (if=6.34, ci=3) 9. Bhattacharya S, Mukherjee O, Mukhopadhyay AK, Pal AK, Dhar KK and Chowdhury R. 2016 A conserved Helicobacter pylori gene, HP0102, is induced upon contact with gastric cells and has multiple roles in pathogenicity J Infect Dis 214: 196-204 (if=6.34, ci=2) 10. Sengupta C, Mukherjee O, Chowdhury R. 2016 Adherence to intestinal cells promotes biofilm formation in Vibrio cholerae J Infect Dis. 214:1571-1578 (if=6.34, ci=1)

347

DAS, NILAY KANTI (b 1976) Professor, Bankura Sammilani Medical College, Kenduadihi, Bankura, WB

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr Nilay Kanti Das graduated in medicine and surgery (MBBS) from Medical College, Kolkata in the year 1998. He has been awarded as ‘University Topper’ while obtaining his post-graduate degree (MD) in Dermatology, Venereology and Leprosy from SSKM Hospital under University of Calcutta. Currently he is pursuing his PhD research on “Clinico-immunological study of Indian Post kala-azar dermal leishmaniasis” in the department of Biotechnology under University of Calcutta and working as ‘Professor’ for Department of Dermatology of Bankura Sammilani Medical College, Bankura. He has been shouldering this responsibility for over last 3 months. Before being promoted to this position has worked as Associate Professor for 4 years period in the Department of Dermatology of Medical College, Kolkata. His interest in infectious diseases was augmented when he was working as resident in dermatology, where he was deeply involved in a tertiary care setting of a tropical region of the country. The significant amount of workload involved obtaining diagnosis and providing care for patients with infectious diseases. Leprosy and Post kala-azar dermal leishmaniasis (PKDL), which are major public health issues and very unique to Indian subcontinent, became his keen areas of interest. His research aimed towards establishing the clinico-immunological correlation in PKDL and leprosy has great impact in both diagnosis and management of the diseases. His work has received numerous accolades among fellow researchers, clinicians from national, international forums with publications in indexed journals. His work also involves the epidemiological research (field trials) to explore the prevalence, susceptibility and bio-markers of PKDL and leprosy. He has also worked on other infectious conditions, such as superficial fungal infections, viral warts, herpes zoster; and non-infectious conditions, like arsenicosis, urticaria, adverse drug reaction, etc. He has received multiple awards and scholarships in the recognition for his work. Few of them are: the prestigious Sukumar Mukherjee Medal Award, B. B. Ghokhale Medal Award, Dr Badri Narayan Prasad Research Award, L N Sinha award, etc. He is engaged for a long time in the clinical management of patients in outpatient and indoor setting and has extensive experience and expertise in handling full life cycle of treatment for severe, rare, time demanding, and serious diseases. He enjoys teaching and mentoring medical and non-medical undergraduates and post-graduates students, and helps them as supervisor for the work towards completing their thesis. He shoulders the responsibility of editing and reviewing articles submitted to bio-medical journals. He is a key resource for teaching, training, research and supportive supervision of National AIDS control organization (NACO) of India and an admired and outspoken member of the Institutional Ethics Committee of Medical College, Kolkata. Proposer: Prof. Arunava Goswami, Seconder: Prof. Ten Best Publications: 1. Mukherjee S, Mukhopadhyay D, Ghosh S, Barbhuiya JN, Das NK†, Chatterjee M. Decreased Frequency and Secretion of CD26 Promotes Disease Progression in Indian Post Kala-azar Dermal Leishmaniasis. J ClinImmunol. 2016 Jan;36(1):85-94.Impact factor: 3.0941 2. Mukhopadhyay D, Mukherjee S, Ghosh S, Roy S, Saha B, Das NK†, Chatterjee M. A male preponderance in patients with Indian post kala-azar dermal leishmaniasis is associated with increased circulating levels of testosterone. Int J Dermatol. 2016 May;55(5):e250-5. Impact factor: 1.415 3. Roy K, Sil A, Das NK‡, Bandyopadhyay D. Effectiveness and safety of clofazimine and pentoxifylline in type 2 lepra reaction: a double-blind, randomized, controlled study. Int J Dermatol. 2015 Nov;54(11):1325-32.Impact factor: 1.415 4. Ghosh S, Das NK*, Mukherjee S, Mukhopadhyay D, Barbhuiya JN, Hazra A, Chatterjee M. Inadequacy of 12-Week Miltefosine Treatment for Indian Post-Kala-Azar Dermal Leishmaniasis. Am J Trop Med Hyg. 2015 Oct;93(4):767-9.Impact factor: 2.453 5. Lal NR, Sil A, Gayen T, Bandyopadhyay D, Das NK†. Safety and effectiveness of autoinoculation therapy in cutaneous warts: a double--blind, randomized, placebo--controlled study. Indian J DermatolVenereolLeprol. 2014 Nov-Dec;80(6):515-20. Impact factor: 0.932 6. Mukhopadhyay D, Das NK*, De Sarkar S, Manna A, Ganguly DN, Barbhuiya JN, Maitra AK, Hazra A, Chatterjee M. Evaluation of serological markers to monitor the disease status of Indian post kala-azar dermal leishmaniasis. Trans R Soc Trop Med Hyg. 2012 Nov;106(11):668-76. Impact factor: 1.631 7. Mukhopadhyay D, Das NK*, Roy S, Kundu S, Barbhuiya JN, Chatterjee M. Miltefosine effectively modulates the cytokine milieu in Indian post kala-azar dermal leishmaniasis. J Infect Dis. 2011 Nov;204(9):1427-36.Impact factor: 6.344 8. Das NK*, Singh SK, Ghosh S, Sarkar A, Mukhopadhyay D, Roy S, Ganguly DN, Barbhuiya JN, Saha B, Chatterjee M. Case series of misdiagnosis with rK39 strip test in Indian leishmaniasis. Am J Trop Med Hyg. 2011 May;84(5):688-91. Impact factor:2.453 9. Ganguly S, Das NK*, Barbhuiya JN, Chatterjee M. Post-kala-azar dermal leishmaniasis--an overview. Int J Dermatol. 2010 Aug;49(8):921-31. Impact factor: 1.415 10.Ganguly S, Das NK*, Panja M, Pal S, Modak D, Rahaman M, Mallik S, Guha SK, Pramanik N, Goswami R, Barbhuiya JN, Saha B, Chatterjee M. Increased levels of interleukin-10 and IgG3 are hallmarks of Indian post-kala-azar dermal leishmaniasis. J Infect Dis. 2008 Jun 15;197(12):1762-71. Impact factor: 6.344 * Lead Author / † Corresponding author / ‡ Senior Author

348

DASH, DEBABRATA (b 1958), Professor, Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

The contributions of nominee over past three decades have carved him a niche in areas of translational nanomedicine and thrombosis. He is credited with design of a novel theranostic platform that combines traditional thrombolytic therapy with state-of-the-art photothermal therapy (gold nanorods irradiated with near-infrared laser) for effective lysis of occlusive pathological thrombi with minimal bleeding complications, thus introducing a smart and safe thrombolytic regimen for future. Nominee has developed a remarkably sensitive and specific impedance-based nano-biosensor to identify/screen individuals with high thrombotic risk. The sensor is based on detection of platelet-derived microparticles in a drop of blood in high-risk individuals. He was first to demonstrate anti-thrombotic propensity of nanosilver for application in coronary stents. He reported thrombogenecity of graphene/nanodiamond and, in counter, synthesized non-toxic nano-isoforms towards safe biomedical applications. Nominee asked the intriguing question ‘how platelets age?’ His study identified Ubiquitin-Proteasome System and Sirtuin Deacetylases as components of putative “Internal Timer” regulating platelet life span, which can be potential therapeutic targets against thrombocytopenia. He validated RhoA-ROCK-MLC (Myosin Light-Chain) axis as anti- Alzheimer drug target in platelet model. Fibrinogen protected neuronal cells as well as platelets from amyloid-β toxicity; thus fibrinogen can be an effective anti-Alzheimer therapeutic tool. Research of nominee is high on translational scale, published in high-impact international journals and widely cited. Nominee is a Fellow of Medical and Science Academies in the country, recipient of ‘Tata Innovation Fellowship’ (DBT), ‘Sun-Pharma Research Award’ and ‘CNR Rao Research Award’, and invited by Rashtrapati Bhavan in recognition of his outstanding research contributions. Proposer: Prof. Arvind Mohan Kayastha, Seconder: Prof. Shyam Sundar Ten Best Publications: 1. Singh, N., Varma, A., Verma, A., Maurya, B.N. & Dash, D. (2016), Nano Res. 9: 2327-2337 (Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective) (if=8.893, ci=2) 2. Sonkar, V.K., Kulkarni, P.P., Chaurasia, S.N., Dash, A., Jauhari, A., Parmar, D., Yadav, S. & Dash, D. (2016), Mol. Med. 22: 224-232 (Plasma fibrinogen is a natural deterrent to amyloid beta-induced platelet activation and neuronal toxicity) (if=3.530, ci=1) 3. Kumari, S., Chaurasia, S.N., Nayak, M.K., Mallick, R.L. & Dash, D. (2015) J. Biol. Chem. 290: 12290- 12299 (Sirtuin inhibition induces apoptosis-like changes in platelets and thrombocytopenia) (if=4. 258, ci=8) 4. Kailashiya, J., Singh, N., Singh, S.K., Agrawal, V. & Dash, D. (2015) Biosens. Bioelectron. 65: 274-280 (if=7.476, ci=21) 5. Sonkar, V.K., Kulkarni, P.P. & Dash, D. (2014) FASEB J. 28: 1819-1829 (Amyloid β peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization) (if=5. 299, ci=13) 6. Kumari, S., Singh, M. K., Singh, S. K., Grácio, J.J.A. & Dash, D. (2014) Nanomedicine 9: 427-440 (Nanodiamond activates blood platelets and induces thromboembolism) (if=4.889, ci=16) 7. Nayak, M.K., Kulkarni, P.P. & Dash, D. (2013) J. Biol. Chem. 288: 6826-6834 (Regulatory role of proteasome in determination of platelet life span) (if=4. 258, ci=21) 8. Singh, S. K., Singh, M. K., Kulkarni P. P., Sonkar V. K., Grácio, J.J.A. & Dash, D. (2012) ACS Nano, 6: 2731-2740 (Amine-modified graphene: Thrombo-protective safer alternative to graphene oxide for biomedical applications) (if=13.334, ci=208) 9. Singh, S.K., Singh, M.K., Nayak, M.K., Kumari, S., Shrivastava, S., Grácio, J.J.A. & Dash, D. (2011) ACS Nano, 5: 4987-4996 (Thrombus inducing property of atomically thin graphene oxide sheets) (if=13.334, ci=136) 10. Shrivastava, S., Bera, T., Singh, S.K., Singh, G., Ramachandrarao, P. & Dash, D. (2009) ACS Nano, 3: 1357-1364 (Characterization of anti-platelet properties of silver nanoparticles) (if=13.334, ci=188)

349

DEEPAK, KISHORE KUMAR (b 1958), Prof. & Head, Departemnt of Physiology, All India Institute of Medical Sciences, New Delhi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr KK Deepak contributed in the field of Autonomic research, Non-pharmacological interventions and biomedical technology. He provided electro-encephalographic and clinical evidence of usefulness of meditation in drug resistant ecliptics In late 90s. Later he conducted the research on effect of Yogic interventions in irritable bowel syndrome (IBS). He showed that maximum beneficial effect was in diarrhea predominant IBS which underwent right nostril breathing intervention. He also published the effect of yoga in Inflammatory Bowel disease. His further studies showed the effectiveness of breathing exercises in diabetes mellitus and life style intervention in bronchial asthma. He also worked on EMG biofeedback intervention in hand dystonia. He established the Autonomic Function Lab in the Department of Physiology in 1989. He investigated the effect of several physiological manoeuvres on autonomic functions. Under his supervision more than 40 disease states have been investigated for autonomic and vascular dysfunctions. This resulted in the regular facility in the department for the assessment of autonomic and vascular function testing for referred patients. He has also carried out research in biomedical signal processing for autonomic functioning and validation of indigenous devices in collaboration with technology institutions. He contributed significantly in the field of medical education through research and training. His philosophy has been to translate physiology into clinical application. He has published 121 research papers in journals and 14 chapters in various books. Proposer: Prof. Y.K. Gupta, Seconder: Prof. Subrat K. Acharya Ten Best Publications: 1. Deepak KK, Manchanda SK, Maheshwari MC. Meditation improves clinicoelectroencephalographic measures in drug-resistant epileptics. Biofeedback and Self-regulation 1994;19 (1); 25-40 [PMID: 8167162]. (if=1.84, ci=77) 2. Sihota R, Gupta V, Agarwal HC, Pandey RM, Deepak KK. Comparison of symptomatic and asymptomatic, chronic, primary angle-closure glaucoma, open-angle glaucoma, and controls. J Glaucoma 2000 Jun;9(3):208-213. [PMID: 10877370] (if=1.86, ci=49) 3. Taneja I, Deepak KK, Poojary G, Acharya IN, Pandey RM, Sharma MP. Yogic versus conventional treatment in diarrhea-predominant irritable bowel syndrome: a randomized control study. Applied psychophysiology and biofeedback 2004, 29 (1), 19-33 [PMID: 15 (if=1.84, ci=117) 4. Mittal CM, Wig N, Mishra S, Deepak KK. Heart Rate Variability is depressed in human-immuno deficiency virus (HIV) positive individuals. Int J of Cardiology. 2004;94:1-6. [PMID: 14996467]. (if=4.03, ci=41) 5. Vempati R, Bijlani RL, Deepak KK. The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial. BMC Pulm Med. 2009 Jul 30;9:37. (if=2.76, ci=109) 6. Sharma P, Makharia G, Ahuja V, Dwivedi SN, Deepak KK. Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission. Dig Dis Scis. 2009;54:853–861 [PMID 18712478]. (if=2.26, ci=39) 7. Mukherjee S, Tripathi M, Chandra PS, Yadav R, Choudhary N, Sagar R, Rafia B, Pandey RM, Deepak KK. Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies. Epilepsy Res. 2009;85(2-3):261-9. [PMID: 19409754]. (if=2.52, ci=69) 8. Misra A, Nigam P, Hills AP, Chadha DS, Sharma V, Deepak KK et al. Consensus physical activity guidelines for Asian Indians. Diabetes technology & therapeutics 2012;14(1):83-98. [PMID: 21988275] DOI: 10.1089/dia.2011.0111 (if=2.18, ci=41) 9. Chandran DS, Ali N, Jaryal AK, Jyotsna VP, Deepak KK. Decreased autonomic modulation of heart rate and altered cardiac sympathovagal balance in patients with Cushing’s syndrome: Role of endogenous hypercortisolism. Neuroendocrinology. 2013;97(4):309- (if=2.58, ci=08) 10. Kaur M, Chandran D, Lal C, Bhowmik D, Jaryal AK, Deepak KK, Agarwal SK. Renal transplantation normalizes baroreflex sensitivity through improvement in central arterial stiffness. Nephrol Dial Transplant. 2013 Oct;28(10):2645-55. doi:10.1093/ndt/gft09 (if=3.85, ci=13)

350

GHOSH, DEEPA (b 1967), Scientist F, Institute of Nano Science and Technology, Mohali

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

I have been following Dr.Ghosh’s scientific progress for the past 15 years. Her contribution in the development of tissue engineered products at Reliance Life Sciences is laudable. Under her guidance, her group had developed several novel tissue engineered products for the treatment of skin related ailments, cartilage and muscle repair. Many of these products have completed phase-2 trials. Her contribution in this field has been acclaimed and she has been honoured with the prestigious NASI- Reliance award for innovation (2012). The department of Biotechnology had recognized her work and provided support to conduct clinical trials on a tissue engineered cartilage substitute. In her pursuit of developing affordable wound management products, she has developed for the first time in India, low cost hydrogel-based advanced wound management products. These are currently marketed under the ReliHeal® range of products. She was instrumental in the development of a fast-acting thrombin-based haemostat, ReliStat® which is currently used in surgeries to stop bleeding. . During the course of her developmental activities, she has gained immense experience in understanding the medical needs of our country. Her focus on developing low cost therapies for addressing the needs of common man is worth mentioning. Her expertise to take the technology from “bench to bedside” is reflected by the number of products that have been marketed or tested in clinical trials. While her product and design patents demonstrate the novelty of her work, her publications in high impact peer reviewed journals reflect her contribution in the area of basic research. Proposer: Dr. Swapan Ghosh, Seconder: Dr. Ashok Ganguli Ten Best Publications: 1. P. Kuchroo, V. Dave, A. Kumar, C. Viswanathan and D. Ghosh* (2015) Paracrine factors secreted by umbilical cord-derived MSCs induce angiogenesis in vitro by a VEGF-independent pathway. Stem Cells and Development 24(4): 437-450. (if=4.1, ci=13) 2. A. Das, A.Kumar, N.Patil, C. Viswanathan and D. Ghosh* (2015) Preparation and characterization of silver nanoparticle loaded amorphous hydrogel of carboxymethylcellulose for infected wounds. Carbohydrate Polymers 130, 254–261. (if=5.22, ci=7) 3. D. Ghosh*, P.Kuchroo, C.Viswanathan, S.Sachan, B.Shah, D.Bhatt, S.G.Parasramani and S.Savant (2012). Efficacy and safety of Autologous Cultured Melanocytes delivered on Poly (DL-lactic acid) film (ReliDerm®M) in the treatment of Stable Vitiligo (if=1.86, ci=5) 4. M. Deshpande, S. Tipnis, P. Shetty, D. Ghosh and C. Viswanathan, (2010) Immunologic properties of human dermal fibroblasts. Human Immunology vol. 71, 1089-1098. (if=2.87, ci=7) 5. D. Ghosh*, S. Shenoy and P. Kuchroo. (2008) Cultured Melanocytes: From skin biopsy to transplantation. Cell Transplantation, 17(3):351-60. (if=6.2, ci=10) 6. D. Thaloor, J. Gephardt, K. Miller and GK.Pavlath (1999) Systemic administration of the NF-kappa B inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am.J. Physiol. 277(2 Pt 1):C320- C329 (if=7.65, ci=154) 7. K. Miller, D. Thaloor, S. Matteson and GK. Pavlath. (1999) Hepatocyte Growth Factor induces myoblast proliferation but inhibits its differentiation in vivo. Am J Physiol Cell Physiol. Jan; 278 (1):C174-81 (if=4.01, ci=205) 8. D. Thaloor, AK. Singh, GS. Sidhu, PV. Prasad, H.Kleinman and RK.Maheshwari.(1998) Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by Curcumin. Cell Growth and Differentiation 9(4):305-312 (if=4.69, ci=207) 9. GK. Pavlath, D. Thaloor, TA. Rando, M. Cheong, AW. English and B.Zheng. (1998) Heterogeneity among muscle precursor cells in adult skeletal muscles with differing regenerative capacities. Developmental Dynamics 212:495-508 (if=2.59, ci=126) 10. GS. Sidhu, AK. Singh, D. Thaloor, KK. Banaudha, G. Patnaik, RC. Srimal and RK.Maheshwari. (1998) Enhancement of Wound Healing by Curcumin in animals. Wound Repair and Regeneration 6(2) 167-77 (if=2.757, ci=221)

351

HARINARAYAN, CHITTARI VENKATA (b 1957), Director, Institute of Endocrinology, Diabetes, Thyroid and Osteoporosis Disorders, Sakra World Hospitals, Sy No 52/2 & 53/3, Deverabeesanahalli (opp Intel, Outer Ring Road), Varathur Hobili, Marathahalli, Bangalore 560103, State

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr. Harinarayan first documented 25OH-Vitamin D(25OHD) deficiency as the predominant cause for radiological bone changes in Primary Hyperparathyroidism in India. In the same work, he demonstrated , in apparently healthy individuals for the first time in the country. This striking observation contradicted the then existing impression of normal Vitamin D status in India – a tropical country. Now this observation has now been confirmed countrywide and Vitamin D deficiency is an important health problem in India. He conducted the first population survey in the country in Andhra Pradesh and documented low vitamin D status and low dietary calcium intake in south Indian population. He demonstrated by in-vitro “Ampoule Model” studies that by exposing 7- Dehydrocholesterol to sunlight on hourly basis the whole day and in various seasons all-round the year, previtamin D synthesis takes place. Hence we as Indians can synthesize enough vitamin D from the skin on exposure to sunlight between 11 am to 2 pm, by exposing 10 to 15% of body surface area for 15 to 30 minutes. He showed the improvement in pancreatic β-cell function with correction of 25OHD deficiency in vitamin D-deficient non diabetic subjects, fall in serum 25OHD levels in patients with anti-epileptic therapy irrespective of the type of drug used, even at therapeutic concentrations, impact of low vitamin D levels in thyroid bone disease, Vitamin D Receptor gene polymorphisms and hypovitaminosis D might predispose to multidrug resistant tuberculosis(MDR-TB) and may increase time to MDR-TB sputum smear negativity. Proposer: Prof. Ravinder Goswami, Seconder: Prof. Sanjeev Sinha Ten Best Publications: 1. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D, Srinivasarao PVLN, Sarma KVS, Kumar EGTV (2007). High prevalence of low dietary calcium, high phytate consumption and vitamin D deficiency in healthy south Indians. Am J Clin Nutr; 85:1062-67 (if=6.770), ci=198 ) 2. Harinarayan CV, Gupta N, Kochupillai N (1995). Vitamin D status in primary Hyperparathyroidism in Northern India. Clinical Endocrinology; 43:351-358. (if=6.209, ci=128 ) 3. Kesavulu M M, Kameswar Rao B, Apparao Ch, E.G.T.V. Kumar, Harinarayan CV (2002). Effect of omega-3 fatty acids on lipid peroxidation and anti-oxidant enzyme status in type – 2 diabetes patients. Diabetes Metab;28:20-26. (if=4.693, ci=119 ) 4. Harinarayan CV (2005). Prevalence of vitamin D insufficiency in postmenopausal south Indian women. Osteop. Int;16:397-402. (if=4.859, ci=162 ) 5. Harinarayan CV, Kochupillai N, Madhu V, Gupta N and Meunier PJ (2006). Endemic Skeletal Flurosis in India. Fluorotoxic metabolic bone disease: an osteo-renal syndrome caused by excess fluoride ingestion in the tropics. Bone;39:907-14. (if=3.736, ci=39 ) 6. Harinarayan CV, Ramalakshmi and Venkata Prasad U (2004). High prevalence of low dietary calcium and low vitamin D status in healthy south Indians, Asia Pac J Clin Nutr;13(4):359-6 (if=1.35, ci=100 ) 7. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D (2008). Vitamin D status in Andhra Pradesh: a population based study. Indian J Med Res. 2008;127(3):211-8. (if=1.446, ci=90 ) 8. Rathored J, Sharma SK, Singh B, Banavaliker JN, Sreenivas V, Srivastava AK, Mohan A, Sachan A, Harinarayan CV, Goswami R (2012).Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D. Int J Tuber16( (if=2.130, ci=90 ) 9. Menon B, Harinarayan CV (2010). The effect of anti epileptic drug therapy on serum 25-hydroxyvitamin D and parameters of calcium and bone metabolism – a longitudinal study. Seizure; 19(3):153-8. (if=2.059, ci=34 ) 10. Chittari V. Harinarayan, Michael F Holick, Upadrasta V. Prasad, Palavali S. Vani and Gutha Himabindu (2013). Vitamin D status and sun exposure in India. Dermato Endocrinology; 5(1):130-141. http://dx.doi.org/10.4161/derm.23873. (if=2.048, ci=22 )

352

KAUR, INDU PAL (b 1965), Professor, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

It is a great pleasure to refer Professor Indu Pal Kaur, who has an expertise in designing nanostructured carrier systems for efficient drug delivery. She has more than 120 high-impact, well-cited publications, 17 filed and one granted patent application, one edited book volume, and two edited journal volumes, besides several conference papers and invited presentations to her credit. Primary focus of Professor Kaur is to develop cost-effective, simple, versatile, scalable and industry- amenable nanostructured systems. She wants to bring industry and patient friendly, low cost, and high performance products to the market. Her work in the area of ocular delivery is taken as a benchmark within and outside India (Aggarwal & Kaur 2005; Kaur and Kakkar 2014). She has improved bioprofile of first line antituberculars in terms of stability, safety and pharmacokinetics using SLNs (Singh et al. 2013; Kaur and Singh 2014; Kumar et al. 2014). She has assigned pharmaceutical couture to natural molecules, extracts and probiotics (Kakkar et al., 2011; Singh & Kaur 2012; Geetha et al. 2015) to elevate their status from protective prophylactics to therapeutic curatives. She has one post-doc, 9 Ph.D scholars and 2 masters students working with her presently. She has produced 12 Ph.D. theses, and 50 post- graduates. It will be an important step forward in the credentials of Prof. Indu Pal Kaur if she is honoured with the NASI Fellowship. Proposer: Prof. Hirendra N. Ghosh, Seconder: Prof. Jatinder Vir Yakhmi Ten Best Publications: 1. Kaur, I. P., Singh, M., & Kanwar, M. 2000. Formulation and evaluation of ophthalmic preparations of acetazolamideInternational Journal of Pharmaceutics.199: 119-127 (if=3.994, ci=109) 2. Aggarwal, D., & Kaur, I. P. 2005. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. International Journal of Pharmaceutics. 290: 155-159 (if=3.994, ci=187) 3. Kaur, I. P., Bhandari, R., Bhandari, S., & Kakkar, V. 2008. Potential of solid lipid nanoparticles in brain targeting. Journal of Controlled Release. 127: 97-109 (if=7.441, ci=335) 4. Kaur, I. P., & Kakkar, S. 2010. Topical delivery of antifungal agents. Expert Opinion on Drug Delivery. 7: 1303-1327 (if=5.434, ci=71) 5. Kakkar, V., Singh, S., Singla, D., & Kaur, I. P. 2011. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Molecular Nutrition & Food Research. 55: 495-503 (if=4.551, ci=174) 6. Bhandari, R., & Kaur, I. P. 2013. Pharmacokinetics, tissue distribution and relative bioavailability of -solid lipid nanoparticles. International Journal of Pharmaceutics 441: 202-212 (if=3.994, ci=60) 7. Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P. 2013. Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats. European Journal of Pharmaceutics and Biopharmaceutics. 85: 339-3 (if=3.975, ci=54) 8. Kaur, I. P., & Singh, H. 2014. Nanostructured drug delivery for better management of tuberculosis. Journal of Controlled Release. 184: 36-50 (if=7.441, ci=35) 9. Kaur, I. P., & Kakkar, S. 2014. Nanotherapy for posterior eye diseases. Journal of Controlled Release. 193: 100-112 (if=7.441, ci=40) 10. Kaur, I. P., Kakkar, V., Deol, P. K., Yadav, M., Singh, M., & Sharma, I. 2014. Issues and concerns in nanotech product development and its commercialization. Journal of Controlled Release. 193: 51-62 (if=7.441, ci=17)

353

KUMAR, LALIT (b 1957), Professor & Head, Department of Medical , AIIMS, New Delhi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr. Kumar has contributed to the development of Medical Oncology discipline at the AIIMS. His major contributions are in the field of (i) bone marrow (BM) /stem cell transplantation (ii) Hematological malignancies with focus on multiple myeloma and (iii) Gynecological malignancies. His group has established a regular, sustained and cost effective stem cell transplant Programme at the AIIMS and has performed more than 600 transplants (both allogeneic and autologous) in the past decade, with results comparable to International standards (Lancet 1994, 1995, Bone Marrow Transplant 2009, Annals Hematology 2011, Clin Lymphoma Myeloma and Leukemia 2013, Cancer Medicine 2014, Leukemia Research 2013). His paper “Leukemia: management of relapse after allogeneic bone marrow transplantation” (J Clin Oncology 1994; 12:1710-17) was considered a classic paper and was reprinted in 2002 under ‘Leukemia: ‘Classic Papers and Current Comments’. His group has rich experience with autologous stem cell transplant for multiple myeloma. Serial studies from their group on infections in acute leukemia patients have helped to reduce the morbidity and mortality associated with leukemia induction treatment (Medical Oncology 2000, 2010, 2012). Kumar has made original contributions in the field of cancer cervix- a common cancer among women in India. These include - use of a novel chemotherapy protocol for recurrent cervix cancer (Gynecol Oncology 1991, J Obst & Gynaecol Res.1998). He was among the first ones to use chemotherapy prior to radiation in advanced cancer of cervix - (Gynecol Oncology 1994 (citations-124), Aust. NZ Med J,1998, Gynecologic Oncology 2013 (citations-26). Proposer : Prof. V.M. Katoch, Seconder : Prof. Subrat K. Acharya Ten Best Publications: 1. Kumar L and Bhargava VL. Chemotherapy in recurrent and advanced . Gynecol Oncol 1991; 40:107-111(IF, 3.774). Citations-45 2. Kumar L, Kaushal R,Nundy M, Biswal BM, Kriplani A, Kumar S, Rath GK, and Kochupillai V. Chemotherapy followed by radiotherapy versus radiotherapy alone in locally advanced cervical cancer : A randomized study. Gynecol Oncology 1994; 54:307-315 (IF, 3.774).Citations-124 3. Kumar L. Leukemia : Management of relapse after allogeneic bone marrow transplantation. J Clin Oncology 1994; 12:1710-1717(IF, 18.428). Citations-68 4. Jagarlmudi R, Kumar L, Kochupillai V, Kapil A, Banerjee U, and Thulkar S. Infections in acute leukemia : An analysis of 240 febrile episodes. Med Oncology 2000; 17:111-116 (IF, 2.634). Citations-69 5. Singh N, Kumar L, Meena R, Velpandian T. Drug monitoring of imatinib levels in patients undergoing therapy for chronic myeloid leukaemia: comparing plasma levels of responders and non-responders. Eur J Clin Pharmacol. 2009 ; 65(6):545-549(IF, 2.966). Citations- 54 6. Kumar L, Ghosh J, Ganessan P, Gupta A, Hariprasad R, Kochupillai V. High-dose chemotherapy with autologous stem cell transplantation for multiple myeloma: what predicts the outcome? Experience from a developing country. Bone Marrow Transplant 2009; 43:481-489 (IF 3.570). Citations-11 7. Gupta A, Singh M, Singh H, Kumar L, Sharma A, Bakhshi S, Raina V, Thulkar S. Infections in - acute myeloid leukemia: an analysis of 382 febrile episodes. Med Oncol. 2010 Dec; 27(4):103745.(IF, 2.634). Citations-52 8. Singh RB, Chander S, Mohanti BK, Pathy S, Kumar S, Bhatla N, Thulkar S, Vishnubhatla S, Kumar L. Neoadjuvant chemotherapy with weekly paclitaxel and carboplatin followed by chemoradiation in locally advanced cervical carcinoma: A pilot study. Gynecol Oncol. 2013; 129(1):124-8 (IF, 3.774) Citatios-26). 9. Goss PE, Strasser-Weippl K, Lee-Bychkovsky BL, Fan L, Li J, Chavarri-Guerra Y, Liedke PE, Pramesh CS, Badovinac-Crnjevic T, Sheikine Y, Chen Z, Qiao YL, Shao Z, Wu YL, Fan D, Chow LW, Wang J, Zhang Q, Yu S, Shen G, He J, Purushotham A, Sullivan R, Badwe R, Banavali SD, Nair R, Kumar L, Parikh P, Subramanian S, Chaturvedi P, Iyer S, Shastri SS, Digumarti R, Soto-Perez-de-Celis E, Adilbay D, Semiglazov V, Orlov S, Kaidarova D, Tsimafeyeu I, Tatishchev S, Danishevskiy KD, Hurlbert M, Vail C, St Louis J, Chan A. Challenges to effective cancer control in China, India, and Russia. Lancet Oncol. 2014 Apr;15(5):489-538. Review (IF, 24.69). Citations-107 10. Talukdar S, Kumar S, Bhatla N, Mathur S, Thulkar S, Kumar L.Neo-adjuvant Chemotherapy in the Treatment of Advanced Malignant Tumors of Ovary. Gynecol Oncol. 2014; 132:28- 32 (IF, 3.774). Citations-17

354

KUMAR, RAKESH (b 1965), Prof. & Head, Diagnostic Nuclear Medicine Division, Dept. of Nuclear Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr Rakesh Kumar, Professor & Head of the Diagnostic Nuclear Medicine Division, Nuclear Medicine at AIIMS, New Delhi. He has been involved in research and teaching for the last 23 years at AIIMS. He has published more than 450 publications in the high impact factor in ‘PUBMED’ indexed journals with more than 6500 citations. He has delivered 130 CME lectures. He has been guide/co-guide to 160 post graduate MD/MS/DM/MCH/PhD students and has published 35 book chapters. He was ‘Guest Editor' of 4 issues of prestigious “PET Clinics” published by Elsevier and also invited to write 6 editorials in reputed international journals. He has been “Editor” of Indian Journal of Nuclear Medicine since 2008. Dr Kumar has received 13 international and 5 national awards . He has also been honored with the Fellowship of National Academy of Medical Sciences(FAMS). Prof Kumar has been awarded with Hari Om Ashram Alembic Research Award by MCI . His original contribution is developing the PET/CT guided biopsy using robotic arm. This is first in the world and has received “First Prize” at Salt Lake City, USA. His group was first to show various clinicopathologic factors associated with false negative PET results in breast cancer (BreastCancerResTreat. 2006;98:267-74). He has designed a new PET/CT technique for evaluation of inflammatory bowel diseases and urinary bladder cancer (Eur J Nucl Med Mol Imaging. 2007;34:2106-14, 2010;37:714-21 and 2013;40:386-93). He has also provided new definition for the detection of ectopic gastric mucosa which is now accepted worldwide (BrJRadiol 2005;78:714-20). Proposer: Dr. Pramod Kumar Garg, Seconder: Dr. Ravinder Goswami Ten Best Publications: 1. Kumar R, Xiu Y, Yu JQ, Takalkar A, El-Haddad G, Potenta S, Kung J, Zhuang H, Alavi A. (2004) 18F- FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med.;45(12):2058-62. (if=6.16, ci=190) 2. R Kumar, S Jana, SI Heiba, M Dakhel, D Axelrod, B Siegel, S Bernik, (2003) Retrospective analysis of sentinel node localization in multifocal, multicentric, palpable, or nonpalpable breast cancer J Nucl Med 44 (1), 7-10 (if=6.16, ci=142) 3. Kumar R, Chauhan A, Zhuang H, Chandra P, Schnall M, Alavi A. (2006) Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat. Aug;98(3):267-74. (if=4.085, ci=142) 4. Kumar R, Basu S, Torigian D, Anand V, Zhuang H, Alavi A.(2008) Role of modern imaging techniques for diagnosis of infection in the era of 18F-fluorodeoxyglucose positron emission tomography. Clin Microbiol Rev.;21(1):209-24. (if=21.25, ci=137) 5. Kumar A, Kumar R*, Seenu V, Gupta SD, Chawla M, Malhotra A, Mehta SN. (2009) The role of 18F- FDG PET/CT in evaluation of early response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Eur Radiol. ;19(6):1347-57. (if=3.64, ci=88) 6. Kumar R, Xiu Y, Zhuang HM, Alavi A.(2006)18F-fluorodeoxyglucose-positron emission tomography in evaluation of primary cutaneous lymphoma. Br J Dermatol. ;155(2):357-63. (if=4.317, ci=58) 7. Kumar R, Sharma P, Garg P, Karunanithi S, Naswa N, Sharma R, Thulkar S, Lata S, Malhotra A (2011). Role of (68)Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours. Eur Radiol.;21(11):2408-16. (if=3.64, ci=56) 8. Das CJ, Makharia G, Kumar R*, Chawla M, Goswami P, Sharma R, Malhotra A. (2007) PET-CT enteroclysis: a new technique for evaluation of inflammatory diseases of the intestine. Eur J Nucl Med Mol Imaging. ;34(12):2106-14. (*Coressponding Author) (if=5.537, ci=44) 9. B Nayak, PN Dogra, N Naswa, R Kumar*. (2013) Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel techniqueEur J Nucl Med Mol Imaging 40 (3), 386-393 (*Coressponding Author (if=5.537, ci=38) 10. Kumar R, Chauhan A, Zhuang H, Chandra P, Schnall M, Alavi A. (2006) Standardized uptake values of normal breast tissue with FDG PET: variations with age, breast density, and menopausal status. Mol Imaging Biol. ;8(6):355-62. (if=2.589, ci=37)

355

MAHESHWARI, MONIKA (b 1975), Associate Professor, Jawahar Lal Nehru Medical College, Ajmer

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

I, know Dr. Monika Maheshwari – Associate Professor (Gn.Med) J.L.N. Medical College Ajmer . She has completed her MBBS, MD (Gn Med), DM (Cardio) from the same institute and has passed out as Gold Medalist. She is the first doctor to do Ph.D. in Echocardiography from University of Rajasthan . She has been awarded Dr. D.P. Basu Award of National API , Dr. D.S. Munagekar Award of National IMA, Prof. M. C. Gupta Oration of Indian Academy of Clinical Medicine, NIMS Best Research paper award of Indian Society of Geriatrics, Gangadhar Verma Memorial Award and Jaipur Apicon Award of Rajasthan API. She is a Fellow of Indian College Of Physicians (FICP ), Indian Society of Electrocardiology (FISE) and Indian Association of Clinical Medicine (FIACM).She is a budding cardiologist with research orientation and has more than 190 publications in International, National and State journals. Her topic on interest is use of Non-Invasive Echocardiography to explore Human Heart , which is appreciated and awarded by various National / State academic societies .I think she is the right and deserving candidate to whom “Fellowship of National Academy of Sciences India ” should be awarded. Hence I would like to propose her name for the prestigious award . Proposer: Prof. Shyam Sundar, Seconder: Prof. Shally Awasthi Ten Best Publications: 1. M Maheshwari, SR Mittal. 2004. Acute myocardial infarction complicating Snake bite. JAPI ; 52: 63-64 (if=0.28, ci=22) 2. M Maheshwari, CP Tanwar. 2012. Scorpion bite induced myocardial damage and pulmonary edema. Heart Views;13: 17-19 (if=0.61, ci=11) 3. M Maheshwari, R K Gokhroo, S K Kaushik. 2012. Isolated Non-compacted Right Ventricular myocardium. JAPI ; 60: 56-57 (if=0.71, ci=10) 4. SRMittal,MMaheshwari.2005.Electrocardiographic changes in Submassive Pulmonary Embolism. Indian Heart Journal ; 57: 80-81 (if=0.34, ci=5) 5. M Maheshwari, S Maheshwari . 2015. Clinico-Radiological Profile and Outcome of Novel H1N1- Infected Patients During 2009 to 2014 Pandemic at Tertiary Referral Hospital in Rajasthan . JAPI; 63 : 42- 5 (if=0.37, ci=5) 6. SR Mittal, M Maheshwari . 2008. Absent left circumflex artery and unusual dominant right coronary artery JAPI; 56, 711 (if=0.56, ci=5) 7. M Maheshwari, SK Kaushik . 2013 . Echocardiographic assessment of left atrial volume index in elderly patients with anterior wall myocardial infarction. JAPI; 61: 310-311 (if=0.76, ci=4) 8. M Maheshwari , SR Mittal. 2004. Right-sided pneumothorax simulating anterior wall myocardial infarction. Indian Heart Journal ; 56 : 72 (if=0.40, ci=4) 9. SR Mittal, M Maheshwari .2006. Amiodarone-induced Exudative Pleural Effusion-A Case Report and Review of Literature.Indian Heart Journal ; 58 : 352 (if=0.46, ci=4) 10. M Maheshwari, SR Mittal.2013. Right ventricle myocardial performance index versus Simpson's right ventricle ejection fraction in patients with isolated left ventricle anterior myocardial infarction.Heart Views; 14 : 68 (if=0.50, ci=3)

356

MALHOTRA, RAJESH (b 1962), Professor & Head Department of Orthopaedics, AIIMS, New Delhi

Member of the NASI: Yes (YON 2017, Medical & Forensic Sciences)

Prof. Rajesh Malhotra’s seminal contributions include establishing the first cadaveric bone bank in India and first surgeon in India to perform hip revision replacements using total acetabular allograft and proximal femoral allografts, patellar tendon-patella composite allograft for patellar tendon loss using innovative technique, Computer Assisted Hip, Partial and Total Knee Replacements, four joint replacement in single sitting, etc. His several international collaborations resulted in innovations. He is an outstanding academician and a researcher with 596 published papers and 2 papers abstracted in Year Books. Prof. Malhotra authored 13 books and contributed 48 chapters in books. He has delivered 616 invited guest lectures and several orations, eponymous lectures and key note addresses. He has been faculty in over 30 International conferences and over 100 papers based on his work have been presented in International conferences. Currently he is the Head of Orthopedics Department at All India Institute of Medical Sciences, New Delhi. Recently, Prof Malhotra was awarded “B C Roy National Award” for Eminent Medical Teacher 2014. He is elected to be President of Indian Orthopaedic Association (2018). He represented India in several International Task Forces/ Consensus Groups and won several awards for his pioneering research. He is a member of several Task Forces of ICMR and DBT and member of the Project Review Committees of DST, DBT and ICMR. He has three dozen research projects/clinical trial to his credit with over two dozen as P.I. Prof. Malhotra is member of many prestigious International organizations like A.O., AAHKS. Proposer: Prof. V K Paul, Seconder: Prof N R Jagannathan Ten Best Publications: 1. Primary pyogenic abscess of the psoas muscle - Malhotra R, Singh KD, Bhan S, Dave PK Journal Bone Joint Surgery 1992: 74A; 278-284 (if=5.163, ci=90) 2. Giant cell tumor of the tendon sheath. Is radiotherapy indicated to prevent recurrence after surgery? Kotwal P P, Gupta Vikas, Malhotra R Journal of Bone and Joint Surg (Br.) 2000 May: Vol. 82; No. 4 571- 573 (if=3.309, ci=125) 3. Surgical management of the severely displaced supracondylar fracture of the humerus in children Rajesh Malhotra Injury 2002; 33(6):517-22 (if=2.137, ci=59) 4. A comparision of Fixed Bearing Vs Mobile bearing total knee Arthroplasty: at minimum followup of 4.5 years. Bhan S, Malhotra R, Krishna KE, Shukla S, Mahesh BH J. Bone Joint Surg. (Am) 2005 (Oct); 87-A: 2290 – 2296 (if=5.163, ci=171) 5. Primary Cementless Total Hip Arthroplasty for Bony Ankylosis in Patients with Ankylosing Spondylitis S Bhan, R Malhotra, E Krishna Kiran Journal of Arthroplasty; September 2008: Vol. 23, Issue 6, Pages 859- 866 (if=2.515, ci=77) 6. Management of extensor mechanism deficit as a consequence of patellar tendon loss in total knee arthroplasty: a new surgical technique R Malhotra, B Garg, V Logani, S Bhan The Journal of arthroplasty 23 (8), 1146-1151 (if=2.515, ci=33) 7. Acute Total Hip Arthroplasty in Acetabular Fractures in the Elderly Using the Octopus System: Mid Term to Long Term Follow-Up. Malhotra R, Singh DP, Jain V, Kumar V, Singh R.: J Arthroplasty 2013Jun; 28(6):1005-9. doi: 10.1016/j.arth.2012.12.003. (if=2.515, ci=8) 8. Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study. Rajesh Malhotra, Vijay Kumar, Ravijot Singh, Bhavuk Garg, Vaibhav Jain, Poonam Coshic, Kabita Chatterjee, Musculoskeletal Surgery. 2015 Dec; 99(3):243-8 (if=1.81, ci=7) 9. Proximal femoral Allograft Prosthesis composite in the treatment of proximal femoral giant cell tumours. Malhotra R, G N Kiran Kumar, V K Digge,Vijay Kumar; The Bone & Joint Journal August 2014. 96-B: 1106-1110. (if=2.66, ci=4) 10. Rajesh Malhotra, Amit Singla, Chandra Lekha, Vijay Kumar, Ganesan Karthikeyan, Vishwas Malik, and Asit R. Mridha, “A Prospective Randomized Study to Compare Systemic Emboli Using the Computer- Assisted Vs Conventional Techniques of Total Knee Arthropl (if=5.163, ci=6)

357

MISHRA, AKHILESH CHANDRA (b 1950), Director, Interactive Research School for Health Affairs (IRSHA), Pune 411043

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Crimean Congo Hemorrhagic Fever: First detection in India, isolation, characterization, molecular clock analysis (19,28,39) Swine Flue (Pandemic Influenza (H1N1): Providing identification to human cases on country level, challenging Investigations of outbreaks, National multi-site surveillance, sero-epidemiology, Genetic characterization, drug resistance surveillance, disease severity studies, meta analysis of global serological surveys, disease burden studies, immunogenicity of vaccines in field, participation in global negotiations for virus and benefit sharing, and vaccine strain selection by Dr Mishra and group created a new culture of response to national health emergencies.(10, 11, 14, 16, 35, 36, 59, 61, 63, 65, 66) Chikungunya: Identification of African genotype, outbreak investigations, Systemic involvements and fatalities, Genetic divergence, diagnostic developments.(24, 48, 72, 77, 81, 85, 90, 111) Avian Influenza (H5N1): Characterization of Indian poultry isolates revealed entries of 3 independent and separate fatal viruses in India. A reverse genetics modified virus was prepared and transferred to Industry for vaccine preparation. Actively participated in pandemic preparedness plans of the country. [69,76,79, 57) Chandipura encephalitis: Comprehensive studies resulted in discovery of new, highly fatal pediatric disease entity in central India. Further studies included investigations of repeated outbreaks, characterization of viruses, standardization of diagnostics, development of vaccine candidates, establishment of network of diagnostic laboratories. (105, 95, 84, 96, 78, 52) Nipah virus: Investigations in Siliguri and other places in West Bengal revealed that Nipah virus, a Biosafety 4 and dangerous select agent was responsible for several fatal outbreaks. The virus was also detected from bats (89, 42, 26). {Refer Annexure 1 for references} Proposer: Prof. U C Chaturvedi, Seconder: Dr. G C Mishra Ten Best Publications: 1. Rao BL------Mishra AC. (2004). A large outbreak of acute encephalitis with high case fatality rate in children in Andhra Pradesh, India in 2003 associated with Chandipura virus. Lancet 364 (9437): 869-74. (if=44, ci=144) 2. Chadha MS, Comer JA, Lowe L, Rota PA, Rollin PE, Bellini WJ, Ksiazek TG, Mishra AC. (2006). Nipah Virus-associated Encephalitis Outbreak, Siliguri, India. Emerging Infect Dis 12: 235-40. (if=6.99, ci=293) 3. Yergolkar PN, Tandale BV, Arankalle VA, Sathe, PS, Sudeep PS, Gandhe SS, Gokhale MD, Jacob GP, Hundekar SL, Mishra AC. (2006). Chikungunya outbreaks caused by African genotype, India. Emerging Infect Dis 12: 1580-83. (if=6.99, ci=308) 4. Arankalle VA, Srivastava S,------Mishra AC. (2007). Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemic. J Gen Virology 88:1967- 76. (if=3.36, ci=218) 5. Bondre VP, Jadi RS, Mishra AC, Yergolkar PN, Arankalle VA. (2007). West Nile Virus isolates from India: evidence for a distict genetic lineage. J Gen virol 88: 875-84. (if=3.36, ci=166) 6. Mishra AC, Cherian SS, Chakrabarti AK, Pawar SD, Jadhav SM, Pal B, Raut S,Koratkar S, Kode SS. (2009). A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India. Virol J. 6-26;1-11. (if=2.36, ci=17) 7. Sapkal GN------Mishra AC, Gore MM. (2009).Enteroviruses in patients with acute encephalitis, Uttar pradesh, India. Emerg Infect Dis. 15(2):295-8. (if=6.99, ci=88) 8. Mishra AC, Chadha MS, Choudhary ML, Varsha, Potdar VA (2010) Pandemic Influenza (H1N1) 2009 Is Associated with Severe Disease in India. PLoS ONE 5(5): e10540. doi:10.1371. (if=5.78, ci=66) 9. Mishra AC, Mehta M, Mourya DT, Gandhi S (2011). Crimean-Congo haemorrhagic fever in India. Lancet 23: 378. (if=44, ci=33) 10. 10. Chadha MS, Potdar VA------Lal RB, Mishra AC. Dynamics of influenza seasonality at sub-regional levels in India and implications for vaccination timing. PLoS One. 2015 May 4;10(5):e0124122. (if=5.78, ci=15)

358

MISHRA, AMIT KUMAR (b 1981), Assistant Professor, Indian Institute of Technology Jodhpur

Member of the NASI: Yes (YON 2017, Medical & Forensic Sciences)

The major focus of Amit’s research has been the role of E3 ubiquitin ligases and chaperones in neurodegenerative diseases, neurodevelopmental disorders and ageing. He has started addressing difficult conceptual problems in the medical field associated with neuroscience and biochemistry of brain. Is there any specific recognition mechanism possible which figures out difference among normal proteins or damaged proteins? What molecular mechanisms regulate its exquisite functionality and determine overall specificity? His research work sincerely contributed in the field of ‘Protein Quality Control Mechanisms’ and understanding the molecular pathomechanisms of neurodegenerative disorders. Amit’s research on the efficiency of the cellular quality control system suggests that there might be an early quality control system in cells, which is governed by E3 ubiquitin ligases and generate first line of defense in cells against by abnormal protein accumulation. He also finds various crucial proteins as substrates of few selective quality control E3 ubiquitin ligases. His work has improved our existing knowledge about crucial mechanisms, which can provide new opportunities to modulate proteins involved in cellular quality control mechanism in neurodegenerative diseases and ageing. Amit has published very well in his chosen field of research and has consistently produced high quality work in leading journal that publish Medical Biochemistry basic research. In near future results of Amit studies may offer the more suitable substitute proteolytic machinery therapeutic strategies to balance the proteostasis for the defective events specifically linked with late-onset neurodegenerative diseases and ageing. Proposer: Prof. Kanury Venkata Subba Rao, Seconder: Prof. Ten Best Publications: 1. Deepak Chhangani, Fumito Endo, Ayeman Amanullah, Arun Upadhyay, Seiji Watanabe; Ribhav Mishra, Koji Yamanaka* and Amit Mishra* (2016) Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and defective in an ALS mouse model. F (if=4.85, ci=5) 2. Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra and Amit Mishra* (2015) Selective Multifaceted E3 Ubiquitin Ligases Barricade Extreme Defense: Potential Therapeutic Targets For Neurodegeneration And Ageing. 2015 Nov;24(Pt B):138-59. (if=7.52, ci=4) 3. Deepak Chhangani, Arun Upadhyay, Ayeman Amanullah, Vibhuti Joshi, and Amit Mishra* (2014) Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins. May 28;4:5077. doi: 10.1038/srep05077 Sc (if=5.22, ci=6) 4. Deepak Chhangani, Nobuyuki Nukina, Masaru Kurosawa, Ayeman Amanullah, Vibhuti Joshi, Arun Upadhyay and Amit Mishra* (2014) Mahogunin ring finger 1 Suppresses Misfolded Polyglutamine Aggregation and Cytotoxicity. 2014 Sep;1842(9):1472-84. doi: 10.1016 (if=5.15, ci=9) 5. Deepak Chhangani and Amit Mishra* (2013) Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity. 2013;3:1972. doi: 10.1038/srep01972 Scientific Reports (Nature Publishing Group) (if=5.22, ci=17) 6. Amit Mishra*, Megha Maheshwari; Deepak Chhangani, Noriko Fujimori Tonou, Fumito Endo, Ajay P Joshi, Nihar R Jana and Koji Yamanaka* (2013) E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. 2013 Apr;34(4):1310.e11-23. do (if=5.15, ci=18) 7. Amit Mishra, Swetha Kameshwari, Megha Maheshwari, Anand Goswami and Nihar Ranjan Jana. (2009) The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of HSP70 bo (if=4.60, ci=63) 8. Amit Mishra, Swetha Kameshwari and Nihar Ranjan Jana. (2009) Angelman syndrome ubiquitin ligase, E6-AP, regulates cell proliferation by promoting proteasomal degradation and altering expression of cyclin-dependent kinase inhibitor p27. Oct;36(1):26 (if=4.85, ci=52) 9. Amit Mishra Priyanka Dikshit., Sudarshana Purkayastha., Jaiprakash Sharma., Nobuyuki Nukina and Nihar Ranjan Jana (2008) E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and (if=4.86, ci=63) 10. Amit Mishra and Nihar Ranjan Jana (2008) Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome. Feb;65(4):656-66.doi: 10.1007/s00018-007-7476-1 Cellular and (if=5.85, ci=36)

359

NATH, GOPAL (b 1961), Professor, Dept. Microbiology, Inst. Medical Sciences, Banaras Hindu University, Varanasi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

We have known Prof. Gopal Nath and have been following his work for the past 26 years. He and his group established the role of Salmonella typhi in causation of Cancer Gall Bladder (CaGB) based on in vitro and in vivo studies (Scanu et al, 2015; Kumar G et al, 2012; Nath G et al, 1008; Prakash P et al, 2005; Shukla VK et al, 2000; Nath Et al, 1997). His findings emphasizeed the need of eradication of Salmonella typhi to help reduce the occurrence of CaGB. His bacteriophage therapy work is commendable and pioneeinmg in nature in India as it can effectively deal with chronic and acute infections caused by multidrug resistant bacteria (Kishore et al, 2015). His work on non putrefying capability of river Ganga is also well recognized. He is the first in India to demonstrate cure of acute as well as chronic bacterial infections through bacteriophage therapy. Prof. Nath also successfully applied phage therapy for the first time in wound healing in patients. His research publications are in well known journals in the field and are cited extensively, including in text-books on Medical Microbiology and Pediatrics. He is on the editorial board of World J of Gastroenterology. He has been elected a Fellow of National Academy of Medical Science, NAMS, New Delhi (2016). Proposer: Prof. S.C. Lakhotia, Seconder: Prof. Rajiva Raman Ten Best Publications: 1. Kishor C, Mishra RR, Saraf SK, Kumar M, Srivastav AK, Nath G. 2016; Phage therapy of Staphylococcal chronic osteomyelitis in experimental animal model. Indian Journal of Medical Research 143 (1), 87-94. 2016 (if=1.446, ci=6) 2. Scanu T, ..... , Nath G, Neefjes J. Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation. Cell Host & Microbe 17 (6): 763–774. 2015 (if=12.57, ci=23) 3. SK Patel, CB Pratap, AK Verma, AK Jain, VK Dixit, G Nath Pseudomonas fluorescens-like bacteria from the stomach: a microbiological and molecular study. World J Gastroenterol 19 (7), 1056-1067. 2013 (if=3.80, ci=15) 4. M Gangwar, VC Verma, TD Singh, SK Singh, RK Goel, G Nath In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus. Asian Pacific journal of tropical medicine 6 (if=0.841, ci=9) 5. G Kumar, CB Pratap, OP Mishra, K Kumar, G Nath. Use of urine with nested PCR targeting the flagellin gene (fliC) for diagnosis of typhoid fever. Journal of Clinical Microbiology 50 (6), 1964-1967. 2012 (if=2.44, ci=11) 6. Nath G, Sigh YK, Kumar K, Gulati AK, Shukla VK, Khanna AK, Tripath SK, Jain AK, Kumar M and Singh TB. Molecular detection of chronic typhoid carriage and its association with carcinoma of the gallbladder in a typhoid endemic area. J Infect Developing (if=1.2, ci=29) 7. Prakash P, Mishra OP, Singh AK, Gulati AK, Nath G. Evaluation of nested PCR in diagnosis of typhoid fever.. J Clin Microbiol. 43: 431-432. 2005 (if=3.537, ci=69) 8. Shukla VK, Singh H, Pandey M, Upadhyay SK , Nath G. Carcinoma of gallbladder: Is it sequel of typhoid? Dig Dis Sci 45: 900-903. 2000 (if=2.11, ci=112) 9. Pandeya SN, Sriram D, Nath G, DeClercq E. Synthesis, antibacterial, antifungal and antiHIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4’ chlorophenyl) thiazol-2- pl]thiosemicarbaside. European J Pharma Science 9:2 (if=3.463, ci=576) 10. Nath G, Singh H, Singh S, Shukla V K. Chronic Salmonella carriers and carcinoma of gallbladder. European J Canc Prev 615: 557-559. 1997 (if=2.415, ci=76)

360

PAUL, GOUTAM (b 1964), Professor (recruited directly) & Ex-Head (3 times), Department of Physiology, & Ex-Dean, Faculty of Science, University of Kalyani, Kalyani, West Bengal-741235

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Professor Goutam Paul is an outstanding teacher, an acclaimed author and a superb scientist in the field of Physiology. His devotion to the Physiology has inspired students enormously over the past three decades. Moreover, Prof. Paul has contributed significantly in promotion and application of Science for the social welfare, and popularization of Science since 1992. The contributions of Prof. Paul are given precisely – (a) Taught Physiology for 29 years and served as Dean of Science (2013-2016). (b) Obtained D.Sc. in Physiology for his pioneering work on arsenic intoxication in intestine. Discovered the gut neuron responsible for arsenic toxicity in smooth muscle which may provide pharmacologic intervention in the treatment of arsenic induced intestinal toxicity in human beings. (c) Developed the Physiology Department at Kalyani University as First Teacher and Head since 2006 and PG Physiology Department, Burdwan University (Hooghly Mohsin College) during 1992-2005. (d) Published nine text-books, 104 research articles in journals and registered 14 GenBank submissions at NCBI. (e) Completed several research projects funded by DST, UGC etc. as PI. (f) Guided 10 PhD students (and 3 students have submitted thesis) including one Fulbright- Nehru Fellow; and thesis and review work of 96 PG students. (g) Popularized science teaching-learning through organizing seminars, science fairs, writing articles in Newspapers; and participating in live programmes of National TV channels. (h) Upgraded and developed 14 Science Departments in University and 98 affiliated colleges as Dean of Science. (I) Participated in Science Academies’ workshop to promote students for pursuing research. Proposer: Prof. Sankar Kumar Ghosh, Seconder: Prof. Syamal Roy Ten Best Publications: 1. A K Maiti, N C Saha, S S More, A K Panigrahi, G Paul. 2017. Neuroprotective Efficacy of Mitochondrial Antioxidant...... Dysfunction Inflicted by Lead Toxicity in the Rat Brain. Neurotox Res. DOI 10.1007/s12640-016-9692-7. (if=3.140, ci=still computing) 2. M Mondal, K Sarkar, P P Nath, G Paul. 2016. Monosodium glutamate depresses the function of female reproductive system in rat by promoting oxidative stress induced changes in the structure of uterus. Int J Pharm Bio Sci. 7(4); (B) 799 -804. (if=6.268 (SJIF), ci=still computing) 3. P P Nath, K Sarkar, M Mondal, Goutam Paul. 2015. Metanil yellow impairs the estrous cycle physiology and ovarian folliculogenesis in female rats. Environmental Toxicology. 2057-2067. DOI: 10.1002/tox.22205. (if=2.868, ci=02) 4. K Sarkar, P Tarafder, G Paul. 2015. Bisphenol A inhibits duodenal movement in vitro of rat through nitric oxide mediated soluble guanylyl cyclase and α-adrenergic signaling pathways. Journal of Applied Toxicology. 36; 131-139. (if=2.722, ci=still computing) 5. A Ghati, G Paul. 2015. Purification and characterization of a thermo-halophilic, alkali-stableand extremely benzene tolerant esterase...... strain AGP-03, isolated from ‘Bakreshwar’ hot spring, India. Process Biochemistry. 50(5); 771-781. (if=2.529, ci=03) 6. A Ghati, K Sarkar, G Paul. 2013. Isolation, Characterization and Molecular Identification of Esterolytic Thermophilic Bacteria from an Indian Hot Spring. Curr Res Microbiol Biotechnol.1(4);196-202. (if=still computing, ci=08) 7. P Tarafder, K Sarkar, P P. Nath, G Paul. 2013. Inhibition of heart ventricular function of rat by Bisphenol A through oxidative stress induced injury of ventricular tissue. Int. J. Pharm. Bio. Sci. 4(2); (B) 811-820. (if=6.268 (SJIF), ci=06) 8. M Ghosh, G Paul. 2013. Intestinal dysfunction and alteration of various systemic and morphometric characters in albino rats (Charles Foster) under stress of inorganic arsenic (iAs) compounds:A pilot study. Int. J. Pharm. Bio. Sci. 4(2);(B) 1008-1016. (if=6.268 (SJIF), ci=03) 9. A K Maiti, G Paul, N C Saha. 2010. Effect of lead on oxidative stress, Na+K+ATPase activity and mitochondrial electron transport chain activity of the brain of Clarius batrachus L. Bull Environ Contam Toxicol, Springer. 84 (6); 672–676. (if=1.191, ci=26) 10. A K Maiti, G Paul, B Maity, N C Saha. 2009.Chromium III Exposure Inhibits Brain Na+K+ATPase Activity of Clarias batrachus L. Involving...... Mitochondrial Electron Transport Chain activity. Bull Environ Contamin Toxicol. 83 (4); 479-483. (if=1.191, ci=04)

361

RAJAMMA, USHA (b 1962), Senior Scientist, Inter University Centre for Biomedical Research & Super speciality Hospital (IUCBR & SSH)

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Autism, in the light of genes, behaviour and neurotransmission Dr. Usha Rajamma made key, decisive contributions in genetics, in the field of Health Sciences, relevant to developmental disabilities (a). She pioneered autism spectrum disorders (ASD) research in India from 2001. ASD is a childhood developmental disorder, ever increasing in its incidence globally. She has clearly defined the neurogenetics of the disorder, in terms of phenotypes and neurotransmission. Scope and relevance of Usha’s work is emphasized ever since her group has established genetic association of serotonergic genes with ASD and established its neurochemical basis in eastern Indian cohort. Her group has demonstrated male-specific effect of serotonergic system genes on the severity of ASD behavioural attributes, through its modulation of serotonin transmission. Parent-of-origin effect in the association of neurodevelopmental genes, Reelin and Engrailed-2 proved to have long-lasting relevance to ASD biology. These discoveries helped to make the public aware of the genetic underpinnings of developmental disabilities, particularly to certain strata of the society in India to a great extent. In a nutshell, her modest contribution in this disability sector is enormously significant that she is regarded as the best in India in the field of ASD genetics. (a) Some major reviews that cited her work (i) Uhlhaas PJ and Singer W (2012) Neuron, 75, 963; (ii) Zeidán-Chuliá F et al. (2014) Neurosci Biobehav Rev. 38:160; (iii) Golub MS et al. (2016) Neuropharmacol. 105: 553; (iv) Crespi & Badcock (2008) Behav. Brain Sci. 31:241 (v) Wang HG et al. (2016) The Neuroscientist 22; 119. Proposer: Prof. Nahid Ali, Seconder: Prof. Pijush Kanti Das Ten Best Publications: 1. Dutta S, Guhathakurta S, Sinha S, Chatterjee A, Ahmed S, Ghosh S, Gangopadhyay PK, Singh M, Usha R (2007) Reelin Gene Polymorphisms in the Indian Population: A Possible Paternal 5'UTR-CGG- Repeat-Allele Effect on Autism. Am J Med Genet Part B: Neur (if=3.391, ci=45) 2. Pandey M, Varghese M, Sindhu KM, Sreetama S, Mohanakumar KP, Usha R (2008) Mitochondrial NAD+-linked state 3 respiration and complex-I activity are compromised in the brain of 3-nitropropionic acid-induced rat model of Huntington’s disease. J. Neu (if=3.842, ci=56) 3. Guhathakurta S, Singh AS, Ghosh S, Sinha S, Chatterjee A, Usha R (2009) Analysis of HTR2A gene: Association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leucocytes. Neuro (if=3.385, ci=22) 4. Pandey M, Borah A, Varghese M, Barman P, Mohanakumar KP, Usha R (2009) Striatal dopamine level influences oxidative stress mediated neurodegeneration in 3-nitropropionic acid-induced Huntington's disease. Neurochem Int. 55:431-437. (if=3.385, ci=19) 5. Sen B, Singh AS, Sinha S, Chatterjee A, Ahmed S, Ghosh S, Usha R (2010) Family-based studies indicate association of Engrailed 2 gene with autism in Indian population. Genes Brain Behav. 9: 248-255. (if=3.275, ci=31) 6. Singh AS, Chandra R, Guhathakurta S, Sinha S, Chatterjee A, Ahmed S, Ghosh S, Rajamma U. (2013) Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian p (if=4.361, ci=8) 7. Verma D, Chakraborti B, Karmakar A, Bandyopadhyay T, Singh AS, Sinha S, Chatterjee A, Ghosh S, Mohanakumar KP, Mukhopadhyay K, Rajamma U. (2013) Sexual dimorphic effect in the genetic association of MAOA markers with autism spectrum disorder. Pro (if=4.361, ci=18) 8. Jaiswal P, Guhathakurta S, Singh AS, Verma D, Pandey M, Varghese M, Sinha S, Ghosh S, Mohanakumar KP, Rajamma U. (2015) SLC6A4 markers modulate platelet 5-HT level and specific behaviors of autism: a study from an Indian population. Prog Neuropsyc (if=4.361, ci=4) 9. Jaiswal P, Mohanakumar KP, Rajamma U. (2015) Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders. Neurosci. Biobehav. Rev. 55:413-431. (if=8.858, ci=9) 10. Chakraborti B, Verma D, Karmakar A, Jaiswal P, Sanyal A, Paul D, Sinha S, Singh AS, Guhathakurta S, Roychowdhury A, Panda CK, Ghosh S, Mohanakumar KP, Mukhophadhyay K, Rajamma U (2016) Genetic variants of MAOB affect serotonin level and specific (if=4.361, ci=0)

362

RAMACHANDRAN, BALARAMAN (b 1948), Professor of Pharmacology, Department of Pharmacy, Sumandeep Vidyapeeth Deemed University, Piparia, Waghodia, Vadodara- 391760.

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Prof. Balaraman, FAMS is one of the senior and eminent pharmacologists having over 40 years of experience in teaching and research. He has made significant contributions in the field of Cardiovascular Research. He did pioneering work on the mechanism of cadmium-induced hypertension He subsequently utilized this model for new drug discovery of synthetic drugs with beta blocking activity to be for the treatment of hypertension. . He then worked on herbal drugs for their significance of dyslipidemia in diabetes and hypertension, which was helpful in the evaluation of anti-hyperlipidemic herbal drugs in such metabolic disorders. During this journey of research he established the role of 5-HT on hypertension, effect of pioglitazone, LNAME and curcumin on endothelial function in diabetic rats. This work was recognized such that Prof T´aˇna Ravingerov´a, Institute for Heart Research, Slovak Academy of Sciences, Slovakia collaborated with Dr Balaraman for the Effect of Hemidesmus indicus and Hibiscus Rosasinensison in Ischemia Reperfusion Injury in Isolated Rat Hearts. Recently his research collaboration with Zydus Research Centre included the role of adipocytokines in romanbant mediated insulin sensitivity in ob/ob mice and Retinol Binding Globulin in cardiovascular complications. One of his research papers entitled “Antidiabetic & antihyperlipidemic effect of neem seed kernel powder on alloxan induced diabetic rabbits” in Indian Journal of Pharmacology got the maximum citation of 300. He guided 20 students for PhD and more than 50 for M. Pharm. He has published more than 125 research papers in International and National journals (h-index 26, citation index >2500). Proposer: Prof. Ramesh K. Goyal, Seconder: Prof. L. S. Chamyal Ten Best Publications: 1. Manoranjan Sharma1, Jogeswar Mohapatra1,*, Umar Malik1, Jignesh Nagar1, Abhijit Chatterjee1, R.Balaraman2 and Mukul R. Jain1 (2016.), Effect of pioglitazone on metabolic features in endotoxemia model in obese diabetic db/db mice, Journal of Diabet (if=2.5, ci=---) 2. Jogeswar Mohapatra, Manoranjan Sharma, Aviseka Acharya, Gaurav Pandya, Abhijit Chatterjee, R. Balaraman and Mukul R. Jain. (2011.) Retinol Binding Protein 4: a possible role in cardiovascular complications. Br J Pharmacol. 164,1939-1948 (if=5.259, ci=21) 3. Vaibhav Patel, Aman Upaganlawar, Rishit Zalawadia, R. Balaraman. (2010)Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. Europea (if=2.73, ci=84) 4. Jogeshwar Mohapatra, M. Sharma, S. Singh, A. Chatterjee, P. Swain, R. Balaraman, P.R.Patel, M. R.Jain (2009),. Subtherapeutic doses of pioglitazone reduce expression of inflammatory adipokines in db/db mice, Pharmacology, 84, 203-210. (if=1.533, ci=12) 5. Jogeshwar Mohapatra, M. Sharma, S. Singh, G. Pandya, A. Chatterjee, R. Balaraman, P.R.Patel, M. R.Jain (2009,). Involvement of adipokines in rimonabant mediated insulin sensitivity in ob/ob mice. Journal of Pharmacy and Pharmacology, 61; 1493 (if=2.264, ci=13) 6. Vipin Dhote and Ramachandran Balaraman (2008).Anti-oxidant activity mediated neuroprotective potential of trimetazidine on focal cerebral ischaemia– reperfusion injury in rats. Clinical and Experimental Pharmacology and Physiology, 35,630-637. (if=2.372, ci=26) 7. Jayesh B Majithiya and R. Balaraman. (2006)Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin induced diabetic rats. Life Sciences,; 78. 2613-2624 (if=2.72, ci=88) 8. Majithiya JB., Paramar AN., R. Balaraman. (2005) Pioglitazone,PPARγ agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats Cardiovascular Research,66(1):150-161. (if=5.465, ci=109) 9. Majithiya JB., R. Balaraman. (2005)Time dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin induced diabetic rats treated with curcumin. Journal of cardiovascular pharmacology, 46 (5); 697-705. (if=2.094, ci=46) 10. Majithiya JB., Paramar AN., Trivedi CJ. R. Balaraman (2005). Effect of pioglitazone on L-NAME induced hypertension in STZ-diabetic rats. Vascular pharmacology. 43; 260-266. (if=3.635, ci=29)

363

RANA, SURINDER SINGH (b 1975), Professor, Postgraduate Institute of Medical Education and Research, Chandigarh

Member of the NASI: Yes (YON 2017, Medical & Forensic Sciences)

Dr Surinder Singh Rana is Professor of Gastroenterology at Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh. His areas of research are pancreatic disorders and therapeutic endoscopy and endoscopic ultrasound (EUS). He has worked on various innovative endoscopic and endoscopic ultrasound methods for treating various pancreatic diseases with minimally invasive methods. To his credit, there are several first time clinical and imaging features of various gastrointestinal disorders. He has published 335 papers of high scientific standard in various journals. He has been awarded various awards and orations including Young Investigator Award by Indian Society of Gastroenterology (ISG), Young Clinician Award by World Gastroenterology Organization, Don Wilson Award (Crystal award) of the American Society of Gastrointestinal Endoscopy, Postgraduate grants by European Society of Gastrointestinal Endoscopy (ESGE), “Shakuntala Amir Chand Award 2006” by Indian Council of Medical Research (ICMR) for significant contribution in biomedical research, “ISG Alkem Omprakash Memorial Award” by the Indian Society of Gastroenterology for significant contribution in research, Young Scientist Medal by Indian National Science Academy, NASI- Scopus Elsevier Young Scientist Award, ISG Zydus Alidac Oration 2015 by Indian Society of Gastroenterology, and ISG-J Mitra Memorial Endoscopy Award (2012) for outstanding contribution in the field of gastrointestinal endoscopy. He has been awarded the fellowship of American Society of Gastrointestinal Endoscopy (ASGE), Society of Gastrointestinal Endoscopy of India (FSGEI) and Association of Interventional GI Endoscopy of India (FAIGE). Proposer: Prof. BC Das, Seconder: Prof. Arunaloke Chakrabarti Ten Best Publications: 1. Rana SS, Sharma V, Sharma RK, Chhabra P, Gupta R, Bhasin DK. (2015) Clinical significance of presence and extent of extrapancreatic necrosis in acute pancreatitis. J Gastroenterol Hepatol.30(4):794- 8. (if=3.322, ci=10) 2. Rana SS, Bhasin DK, Sharma RK, Kathiresan J, Gupta R. (2014) Do the morphological features of walled off pancreatic necrosis on endoscopic ultrasound determine the outcome of endoscopic transmural drainage? Endosc Ultrasound.;3(2):118-22. (if=2.794, ci=27) 3. Babu RY, Gupta R, Kang M, Bhasin DK, Rana SS, Singh R. (2013) Predictors of surgery in patients with severe acute pancreatitis managed by the step-up approach. Ann Surg. ;257(4):737-50. (if=8.569, ci=103) 4. Rana SS, Bhasin DK, Rao C, Gupta R, Singh K. (2013) Non-fluoroscopic endoscopic ultrasound- guided transmural drainage of symptomatic non-bulging walled-off pancreatic necrosis. Dig Endosc. 25(1):47-52. (if=2.715, ci=38) 5. Santhosh S, Mittal BR, Bhasin D, Srinivasan R, Rana S, Das A, Nada R, Bhattacharya A, Gupta R, Kapoor R. Role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: experience from t (if=3.322, ci=33) 6. Rana SS, Bhasin DK, Chandail VS, Gupta R, Nada R, Kang M, Nagi B, Singh R, Singh K. (2011) Endoscopic balloon dilatation without fluoroscopy for treating gastric outlet obstruction because of benign etiologies. Surg Endosc. ;25(5):1579-84 (if=3.540, ci=25) 7. Rana SS, Bhasin DK, Srinivasan R, Singh K. (2011) Endoscopic ultrasound-guided fine needle aspiration of peritoneal nodules in patients with ascites of unknown cause. Endoscopy. ;43(11):1010-3. (if=5.634, ci=17) 8. Bhasin DK, Rana SS, Nanda M, Chandail VS, Masoodi I, Kang M, Kalra N, Sinha SK, Nagi B, Singh K. (2010) Endoscopic management of pancreatic pseudocysts at atypical locations. Surg Endosc. 24(5):1085-91 (if=3.540, ci=32) 9. Rana SS, Bhasin DK, Nanda M, Singh K. (2007) Parasitic infestations of the biliary tract. Curr Gastroenterol Rep.9(2):156-64. (if=1.000, ci=74) 10. Bhasin DK, Rana SS, Udawat HP, Thapa BR, Sinha SK, Nagi B. (2006) Management of multiple and large pancreatic pseudocysts by endoscopic transpapillary nasopancreatic drainage alone. Am J Gastroenterol. 101(8):1780-6 (if=10.383, ci=40)

364

SAGAR, RAJESH (b 1964 ), Professor of Psychiatry, All India Institute of Medical Sciences, New Delhi

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Dr Rajesh Sagar, as clinician developed the services for Child and Adolescent Psychiatry and started the separate inpatient services in his institution. He has significant experience as a policy expert and has expertise in conducting community research related to mental health at the national and international level. In the capacity as Secretary, Central Mental Health Authority and honorary advisor on mental health for DGHS, MoHFW, Govt. of India., he has been involved in the National Mental Health Program and has worked to strengthen Psychiatry in undergraduate medical education. He has been involved with development of national mental health policy, the new mental health care bill, insurance cover for mentally ill persons, training program for primary care doctors etc. Dr Sagar is an excellent clinician, academician and researcher par excellence. He has successfully accomplished 90 funded research projects as investigator. His work has been published more than 300 articles in peer-reviewed national and international journals/books/chapters. He has also been a guide/co-guide of 96 MD/MS/DM/MSc thesis research work in addition to 30 PhD students. He has made important contribution at international level such as coordinator and principal investigator of pioneering work in India on World Mental Health Survey, supported by the WHO (HQ) and Harvard Medical School, USA and many more international projects. He conducted the Audit of Mental Health services in Maldives, awarded International Exchange Program by Royal Society of Edinburgh for the Robert Gordon University, Aberdeen UK and Academic faculty (visitor) by department of Psychiatry, University of Melbourne, Australia. Proposer: Prof. N. R. Jagannathan, Seconder: Prof. Ravinder Goswami Ten Best Publications: 1. Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA,… Sagar R, .. (2011). Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 68(3):241-51. (if=14.480, ci=839) 2. Kessler RC, McLaughlin KA, Green JG, …Sagar R, …. (2010). Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 197:378-85 (if=7.991, ci=542) 3. Nock MK, Hwang I, Sampson N, …Sagar R, … (2009). Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO World Mental Health Surveys. PLoS Med. 6(8):e1000123. (if=16.269, ci=400) 4. Kessler RC, Green JG, Gruber MJ, …Sagar R,… (2010). Screening for serious mental illness in the general population with the K6 screening scale: results from the WHO World Mental Health (WMH) survey initiative. Int J Methods Psychiatr Res.19 Suppl (if=3.759, ci=296) 5. Borges G, Nock MN, Abad JMH, …Sagar R, … (2010). Twelve-Month Prevalence of and Risk Factors for Suicide Attempts in the World Health Organization World Mental Health Surveys, J Clin Psychiatry. 71(12), 1617. (if=5.812, ci=271) 6. Kessler RC, Ormel J, Petukhova M, McLaughlin KA, Green JG, Russo LJ, Stein DJ, Zaslavsky AM, Aguilar-Gaxiola S, Alonso J, Andrade L, Benjet C, de Girolamo G, de Graaf R, Demyttenaere K, Fayyad J, Haro JM, Hu C, Karam A, Lee S, Lepine JP, Matchsing (if=14.480, ci=227) 7. Kessler RC, Birnbaum HG, Shahly V, Bromet E, Hwang I, McLaughlin KA, Sampson N, Andrade LH, de Girolamo G, Demyttenaere K, Haro JM, Karam AN, Kostyuchenko S, Kovess V, Lara C, Levinson D, Matschinger H, Nakane Y, Browne MO, Ormel J,Posada-Villa J, (if=5.004, ci=222) 8. Bruffaerts R, Demyttenaere K, Borges G, Haro JM, Chiu WT, Hwang I, Karam EG, Kessler RC, Sampson N, Alonso J, Andrade LH, Angermeyer M, Benjet C, Bromet E, de Girolamo G, de Graaf R, Florescu S, Gureje O, Horiguchi I, Hu C, Kovess V, Levinson D, P (if=7.991, ci=158) 9. Stein DJ, Chiu WT, Hwang I, Kessler RC, Sampson N, Alonso J, Borges G, Bromet E, Bruffaerts R, de Girolamo G, Florescu S, Gureje O, He Y, Kovess-Masfety V, Levinson D, Matschinger H, Mneimneh Z, Nakamura Y, Ormel J, Posada-Villa J, Sagar R, Scott (if=16.269, ci=150) 10. Alonso, J., Petukhova, M., Vilagut, G., Chatterji, S., Heeringa, S., Üstün, T. B., … Kessler, R. C. (2011). Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys. Molecular Psychiatry, 16( (if=15.147, ci=145)

365

SAXENA, SANDEEP (b 1965), Professor and Chief of Retina Service, Department of Ophthalmology, King George's Medical University, Lucknow, India

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

Prof. Sandeep Saxena has contributed scientifically over past twenty-four years. He was awarded Post- Doctoral Fellowships at Anheuser-Busch Eye Institute and Barnes Retina Institute, St. Louis (1995-96) and New York-Presbyterian Hospital of Columbia and Cornell, New York, (2000-01; Ivy-league institution) USA. He was awarded prestigious Visiting Fellowships at Harvard University, USA (2016), Oxford University, UK (2015), DAAD Fellowship-Bonn University, Germany (2009) and three international Visiting Professorships. In diabetic retinopathy, he provided novel insight into retinal photoreceptor ellipsoid zone disruption using, spectral-domain optical coherence tomography (SDOCT). He defined the role of imaging and biochemical biomarkers in disease progression. He discovered the role of several bio-molecules: VEGF, ICAM-1, NεCML and antimyeloperoxidase antibody that cause retinal dysfunction (Molecular Vision 2013; Diabetes Complications 2016; Retina 2016). He developed and published three SDOCT- based classification systems (Clinical Experimental Ophthalmology 2015). In Eales’ disease, he discovered autoimmunity and cytokine dysfunction in pathogenesis (Pathobiology 1999, 2011; Ocular Inflammation-Immunology 2009). He published a novel grading system incorporating disease severity and management strategies, introduced novel low-cost medical therapy and paved way for newer immunotherapy approaches (European Ophthalmology 2004, 2005). His original pioneering research provided unique insight into pathogenesis, unravelled new approaches for drug therapies and defined classification systems for better understanding, disease monitoring and planning management in Diabetic retinopathy and Eales’ disease. He also provided innovative insight into 3-dimensional SDOCT-based retinal research (BMJ-CR 2012-2016). He has 120 published articles in indexed journals, 15 textbooks and 34 book chapters. He designed an innovative instrument ‘Saxena Retinal Grid-520 & 428’ (Ocular Instruments, USA). Proposer: Prof. Asha Mathur, Seconder: Prof. Prahlad K Seth Ten Best Publications: 1. Saxena S, Rajasingh J, Biswas S, Kumar D, Shinohara T, Singh VK. 1999.Cellular immune response to Retinal S-antigen and Interphotoreceptor Retinoid Binding Protein fragments in Eales’ disease patients. Pathobiology 67:37-44. Switzerland.. (if=2.48, ci=38) 2. Rai G, Saxena S, Kumar H, Singh VK. 2001. Human Retinal S-antigen: T cell epitope mapping in posterior uveitis patients. Experimental and Molecular Pathology 70:140-145. U.S.A. (if=2.98, ci=28) 3. Lincoff H, Madjarov B, Lincoff N, Movshovich A, Saxena S, Coleman DJ, et al. 2003. Pathogenesis of the vitreous cloud emanating from subretinal hemorrhage.Archives of Ophthalmology 121:91-96. U.S.A. (if=4.34, ci=22) 4. Tripathi P, Saxena S, Yadav VS, Naik S, Singh VK. 2004. Human S-antigen: peptide determinant recognition in uveitis patients.Experimental and Molecular Pathology 76:122-128. U.S.A. (if=2.98, ci=14) 5. Lincoff H, Stopa M, Kreissig I, Madjarov B, Saxena S, Sarup V, Brodie S.2006. Cutting the encircling band. Retina 26:650-654. U.S.A. (if=3.24, ci=46) 6. Saxena S, Khanna VK, Pant AB, Meyer CH, VK Singh. 2011. Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative Eales’ disease.Pathobiology 78: 261-265. Switzerland (if=2.48, ci=9) 7. Jain A, Saxena S, Khanna VK, Shukla R, and Meyer CH.2013. Status of serum VEGF and ICAM-1 and its association with external limiting membrane and IS-OS junction disruption in type 2 diabetes mellitus.Molecular Vision 19:1760-68. U.S.A. (if=2.48, ci=30) 8. Sharma S, Saxena S, Srivastav K, Shukla RK, Mishra N, Meyer CH, et al. 2015. Clinical & Experimental Ophthalmology 43: 429-436, Australia (if=1.88, ci=20) 9. Mishra N, Saxena S, Shukla RK, Singh V, Meyer CH, Kruzliak P, et al. 2016. Association of serum N ε- Carboxy methyl lysine with severity of diabetic retinopathy. Journal of Diabetes and its Complications 30: 511-517. Europe (if=3.01, ci=5) 10. Sinha S, Saxena S, Das S, Prasad S, Bhasker SK, Mahdi AA, Kruzliak P. 2016. Antimyeloperoxidase antibody is a biomarker for progression of diabetic retinopathy. Journal of diabetes and its Complications 30: 700-704. Europe (if=3.01, ci=2) 366

SENGUPTA, SHARMILA (b 1959), Professor/Director (additional charge), National Institute of Biomedical Genomics, P.O.: N.S.S., District- Nadia, Kalyani- 741251, West Bengal

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

The nominee’s studies on cervical cancer (CaCx) pathogenesis focus on deciphering the role of host pathogen interactions at the genetic and epigenetic levels. She established the role of episomal HPV16 in CaCx causation, besides HPV integration, and identified genetic variations, coding and non-coding, within the host genome that impart disease risk (Cancer Lett, 188, 207-21, 2002; Gynecol Oncol. 99, 176-182, 2005; The Lancet Oncology 10, 772-784, 2009; Cellular Oncology 39, 559-572, 2016 and Int J of Cancer, DOI: 10.1002/ijc.3068, 2017). Also, the studies reveal mechanisms adopted by HPV16 for mediating disease risk, involving methylation and sequence variations in transcription factor and microRNA binding sites of the viral promoters (Virology 354, 280-285, 2006; PLoS ONE 7(9): e44678. doi:10.1371/journal.pone.0044678, 2012 and PLoS ONE 8(6): e65647. DOI:10.1371/journal.pone. 0065647, 2013) and enhanced host global DNA methylations within Alu I repeat sequences (Tumor Biology, DOI: 10.1177/1010428317699799 journals.sagepub.com/home/tub, 2017). Subsequently, her studies identified (i) the changes in the host transcriptome in CaCx pathogenesis, specifically HOX cluster encoded protein-coding transcripts and long noncoding RNAs (lncRNAs), and (ii) their roles in CaCx development, in association with HPV16. These highlighted the master regulatory role of HPV16 E7 in modulating the expression of HOX cluster genes through abrogation of HOTAIR function (Scientific Reports 5:11724, DOI: 10.1038/srep1172, 2015)in association with epigenetic regulation of such gene promoters involving enrichment of chromatin active and and loss of chromatin suppressive histone marks, H3K4me3 and H3K27me3, respectively[Oncotarget, DOI: 10.18632/oncotarget.16619 (Advance Publication, 2017]. Such findings are of enormous relevance for cervical cancer prevention and therapy. Proposer: Prof. Partha P. Majumder, Seconder: Dr. Susanta Roychoudhury Ten Best Publications: 1. Bhattacharya P, Duttagupta C and Sengupta S (2002). Proline homozygosity in codon 72 of p53: a risk genotype for human papillomavirus related cervical cancer in Indian women. Cancer Lett, 188, 207-211 (if=5.992, ci=47) 2. Bhattacharya P and Sengupta S (2005). Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21 jointly mediate cervical cancer susceptibility among Indian women. Gynecol Oncol. 99, 176-182. (if=3.774, ci=26) 3. Bhattacharjee B and Sengupta S (2006). CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 354, 280-285. (if=3.351, ci=94) 4. Bhattacharjee B and Sengupta S. (2006). HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women. Gynecol Oncol. 100, 372-378. (if=3.774, ci=37) 5. Klug SJ, Ressing M, Koenig J, Abba MC, Agorastos T, Brenna S MF, Ciotti M, Das BR, Del Mistro A, Dybikowska A, Giuliano AR, Gudleviciene Z, Gyllensten U, Haws ALF, Helland A, Herrington CS, Hildesheim A, Humbey O, Jee SH, Kim JW, Madeleine MM, Me (if=26.509, ci=125) 6. Das Ghosh D, Bhattacharjee B, Sen S, Laikangbam P, Mukhopadhyay I, Roy Chowdhury R, Roy S and Sengupta S (2012). Some novel insights on HPV16 related cervical cancer pathogenesis based on analyses of LCR methylation, viral load, E7 and E2/E4 exp (if=3.234, ci=21) 7. Sharma S, Mandal P, Sadhukhan T, Roy Chowdhury R, Mondal N.R., Chakravarty B, Chatterjee T, Roy S and Sengupta S (2015). Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis. Scientific Reports 5 (if=5.228, ci=25) 8. Saha Sharma, S., Roy Chowdhury, R., Mondal, N.R., Chakravarty, B., Chatterjee, T., Roy, S., and Sengupta, S. (2016). Identification of genetic variation in the lncRNA HOTAIR associated with HPV16- related cervical cancer pathogenesis. Cellular Onc (if=3.562, ci=not yet cited) 9. Das Ghosh, D., Mukhopadhyay, I., Bhattacharya, A., Roy Chowdhury, R., Mandal, N.R., Roy, S.,and Sengupta, S (2017). Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer pathogenesis. International J (if=5.531, ci=not yet cited) 10. Saha Sharma, S., Roy Chowdhury, R., Mandal, N.R., Roy, S.,and Sengupta, S (2017). Expression signatures of HOX cluster genes in cervical cancer pathogenesis: Impact of human papillomavirus type 16 oncoprotein E7. Oncotarget, DOI: 10.18632/oncota (if=5.008, ci=not yet cited)

367

SETH, PANKAJ (b 1968), Scientist VI and Professor, National Brain Research Centre, Manesar

Member of the NASI: Yes (YON 2017, Medical & Forensic Sciences) a) Dr. Seth’s laboratory was first to demonstrate clade specific differences in HIV-1 neurotoxicity are attributed to dicysteine motif (C30C31) in Tat protein of HIV-1 subtype B prevalent in North America and Europe. He demonstrated that in HIV-1 clade C, that is prevalent in India, dicysteine motif is lacking due to natural mutation in viral protein. This provided scientific basis for clinical observations of milder neuroAIDS in India (Mishra et al AnnalsOfNeurology2008). b) Subsequently he demonstrated, HIV-1 Tat affects stemness of human neural stem cells (hNSCs) by perturbing cell cycle regulator-cyclin D1 and expression profiles of genes important for hNSC proliferation and differentiation (Mishra et al JNV2010). c) Furthermore, Dr. Seth delineated cellular-molecular mechanisms underlying comorbidity of HIV-1 and drug abuse (Malik et al PloS one 2011) and established involvement of extracellular signal-regulated kinase (ERK1/2)-p53-p21 axis in mediating neural stem/progenitor cell cycle arrest in HIV-drug abuse co- morbidity (Malik et al JNIP2014). d) He further provided novel insights into role of TRIM32 in HIV-1 induced modulation of hNSCs, identification of novel role of miR-155 in hNSCs and miR-320a-VDAC1 axis in astrocyte-mediated neuronal damage in neuroAIDS, most of which were validated in post mortem brain samples of AIDS patients (Fatima et al CDD2016; GLIA2017). Dr. Seth has also established role of ligand gated ion channel purinergic receptor-P2X7R in astrocyte mediated neuronal damage in neuroAIDS (Tewari et al JNC2015). e) Prof. Seth’s laboratory established a unique human neural stem cell platform in India for understanding various neurodegenerative disorders, being used by various institutions. Proposer: Prof. Prakash N Tandon, Seconder: Prof. Subrata Sinha Ten Best Publications: 1. Y. Adlakha and P. Seth (2017). The Expanding Horizon of MicroRNAs in Cellular Reprogramming. Progress in Neurobiology Jan 148:21-39. (if=13.177, ci=published this year, Yet to be cited) 2. M. Fatima, B. Prajapati, K. Saleem, R. Kumari , C. Singal, Mohindar Singh Singal P.Seth (2017). Novel insights into role of miR-320a-VDAC1 axis in astrocyte-mediated neuronal damage in neuroAIDS. Glia 65(2):250-263. (if=5.997, ci=published this year, Yet to be cited) 3. P. Seth (2016). NeuroAIDS: Past, Present and Future; EDITORIAL (Invited) In: Current HIV Research 14 (5): 372 (if=1.562, ci=Yet to be cited) 4. M Fatima, R Kumari, JC. Schwamborn, A Mahadevan, SK. Shankar, R Raja, and P. Seth (2016). Tripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 NeurodegenerationCell Death and Differentiation May;23(5):776-86 (if=8.218, ci=3) 5. M. Tewari and P. Seth (2015). Emerging Role of P2X7 Receptors in CNS Health and Disease. Ageing Research Reviews Nov 24 (Pt B):328-42. (doi: 10.1016/j.arr.2015.10.001) (if=7.526, ci=6) 6. M. Tewari, Monika, R. Verghese, M. Menon and P. Seth (2015). Astrocytes mediate HIV-1 Tat-induced neuronal damage via ligand-gated ion channel, P2X7R. Journal of Neurochemistry 132: 464-476 (Featured on the Cover page of the Journal) (if=3.842, ci=5) 7. S. Malik, R. Saha and P. Seth (2014). Involvement of Extracellular signal-regulated kinase (ERK1/2)- p53-p21 axis in mediating neural stem/progenitor cell cycle arrest in co-morbid HIV-Drug abuse exposure. Journal of Neuroimmune Pharmacology 9:340-353 (if=3.896, ci=7) 8. S. Malik, H. Khalique, S. Buch and P. Seth (2011). A Growth Factor Attenuates HIV-1 Tat and Morphine Induced Damage to Human Neurons: Implication in HIV/AIDS-Drug Abuse Cases. PLoS One 6 (3): e18116 (if=3.234, ci=18) 9. M Mishra, M. Taneja, S. Malik, H. Khalique, and P. Seth (2010). HIV-1 Transactivating Protein Attenuates Human Neural Stem Cell Proliferation and Differentiation: Implication in Pathogenesis of NeuroAIDS. J of Neurovirology16(5):355-67 (if=2.243, ci=17) 10. M. Mishra, S. Vitrevel, N.B. Sidappa, U. Ranga and P. Seth (2008). Clade Specific Neurotoxicity of HIV Tat in Human Neuron: Significance of Dicysteine C30C31 Motif. Annals of Neurology 63: 366-376 (if=9.935, ci=87)

368

SHARMA, JAI BHAGWAN (b. 1960) Professor, Deptt. of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi-110029

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Prof. J. B. Sharma has made significant contributionsin the field of Obstetrics and Gynaecology. He has completed two research projects entitled “CORONIS International study of caesarean section surgical techniques: a randomised factorial trial” from 2004-2007and “CORONIS International study of caesarean section surgical techniques: the follow-up study” from 2007-2014 with NPEU University of Oxford with two publications in The Lancet. He has about 300 publications with 150 being in Pubmed indexed journals including 20 on various aspects of female genital tuberculosis(FGTB), including a land mark RCT published in European Journal of Obstetrics and Gynaecology which has proven the efficacy of 6 months antituberculosis therapy female genital tuberculosis. He has developed new laparoscopic sign in FGTB like Sharma’s Blue Python Sign, Sharma’s Hanging Gallbladder Sign, Sharma’s Ascending Colonic Adhesion, Sharma’s Kissing Fallopian tube sign and Sharma’s Dried Tree Branch Fallopian Tubes Sign. He has 30 years (20 years as faculty) experience in the obstetrics and gynaecology including 4 years in various UK hospitals. He is a popular under graduate and postgraduate teacher and examiner for MRCOG, MD, DNB, DGO and MBBS examinations. He has written and edited 5 books is editor of 2 journals and is on the editorial board of 4 other journals & reviewers for many International and national journals. He has organized many conferences and CMEs and has delivered lectures in various international and national conferences. Proposer : Prof. S.K. Sharma, Seconder : Prof. Sanjeev Sinha Ten Best Publications : 1. Abalos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, Gray S, Hardy P, Juszczak E, Mathews JE, NazMasood S, Oyarzun E, Oyieke J, Sharma JB, Spark P. Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial. CORONIS collaborative group, Lancet. 2016 Jul 2; 388 (10039):62-72. (IF: 44.00, Citation:03) 2. Abalos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, Gray S, Hardy P, Juszczak E, Mathews JE, Masood SN, Oyarzun E, Oyiek J, Sharma JB, Spark P. Caesarean section surgical techniques (CORONIS): a fractional, unmarsked, randomized controlled trial. CORONIS Collaborative Group Lancet. 2013 Jul 20;382(9888):324-48. (IF: 44.00, Citation:06) 3. Sharma JB, Jain S, Mallika V, Singh T, Kumar A, Arora R, Murthy NS. A prospective, partially randomized study of pregnancy outcomes and hematologic responses to oral and intramuscular iron treatment in moderately anemic pregnant women. Am J ClinNutr. 2004 Jan;79(1):116-22. (IF:6.70, Citation:16) 4. Sharma JB, Singh N, Dharmendra S, Singh UB, P V, Kumar S, Roy KK, Hari S, Iyer V, Sharma SK. Six months versus nine months anti-tuberculous therapy for female genital tuberculosis: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016 Jun 28; 203:264-273. (IF: 1.66, Citation: 00) 5. Sharma JB, Kumar A, Kumar A, Malhotra M, Arora R, Prasad S, Batra S. Effect of lycopene on pre- eclampsia and intra -terine growth retardation in primigravidas. Int J Gynecol Obstet. 2003; 81(3):257-62. (IF: 1.67, Citation:07) 6. Sharma JB, Roy KK, Pushparaj M, Kumar S. Hysteroscopic findings in women with primary and secondary infertility due to genital tuberculosis. Int J Gynecol Obstet. 2009 ;104(1):49-52. (IF: 1.67, Citation:13) 7. Sharma JB, Bumma SD, Saxena R, Kumar S, Roy KK, Singh N, Vanamail P. Cross sectional, comparative study of serum erythropoietin, transferrin receptor, ferritin levels and other hematological indices in normal pregnancies and iron deficiency anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2016 May 20;203:99-103. (IF: 1.66, Citation:00) 8. Sharma JB, Roy KK, Pushparaj M, Kumar S, Malhotra N, Mittal S. Laparoscopic findings in female genital tuberculosis. Arch Gynecol Obstet. 2008 Oct;278(4):359-64. (IF: 1.68, Citation:26) 9. Sharma JB, Karmakar D, Hari S, Singh N, Singh SP, Kumar S, Roy KK. Magnetic resonance imaging findings among women with tubercular tubo-ovarian masses. Int J Gynecol Obstet. 2011;113:76-80. (IF: 1.67, Citation:04) 10. Sharma JB, Karmakar D, Kumar R, Shamim SA, Kumar S, Singh N, Roy KK, Reddy RM. Comparison of PET/CT with other imaging modalities in women with genital tuberculosis. Int J Gynecol Obstet. 2012;118:123-8. (IF: 1.67, Citation: 02 )

369

SRIVASTAVA, DEEP NARAYAN (b 1958), Professor, All India Institute of Medical Sciences, (AIIMS), New Delhi – 110029.

Member of the NASI: No (YON 2017, Medical & Forensic Sciences)

He is working in all modalities but has developed and established some advanced techniques in Interventional Radiology & MRI in last 25 years. He has established various IR techniques in India which are minimally invasive life saving procedures. These procedures are now viable alternatives to traditional invasive therapies and can be performed in the outpatient settings and also as a life saving or palliative or as a standard treatment method. In IR he started angiographic radioembolization in liver cancer for the first time in India under a multicentre trial funded by IAEA, established round the clock facility of life saving minimally invasive IR procedures at AIIMS by a well trained team for the management of tuberculosis and lung cancer patients, vertebroplasty – a minimally invasive procedure to treat osteoporosis common in elderly population making them self sufficient and ambulatory (walking independently) , Uterine artery embolization a life saving procedure in post delivery / post-operative obstetrical haemorrhages etc. For training of these IR procedures he developed a low cost indigenous phantom, made from locally available materials for training. He has also developed few indigenous (Homemade) techniques /materials which are useful for life saving procedures with no cost to patient. In MRI he started doing MR arthrography and established this technique, MR guided biopsy techniques etc. He has few prestigious awards to his credit Proposer: Prof. N R Jagannathan, Seconder: Prof. Ravinder Goswami Ten Best Publications: 1. Gastrointestinal hemorrhage in hepatocellular carcinoma: management with transhepatic arterioembolization. DN Srivastava, D Gandhi, PK Julka et al. Abd Imaging, 2000, 25(4): 380-384. (if=1.9, ci=24) 2. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. DN Srivastava, D Gandhi, A Seith et al. Abd Imaging, 2001, 26(5): 510-4. (if=1.9, ci=98) 3. Colour Doppler flow imaging of focal hepatic lesions. DN Srivastava, A Mahajan, M Berry et al. Australasian Radiology, 2000, 44(3): 285-289. (if=Not available, ci=15) 4. Gastric volvulus: acute and chronic presentation. G Shivananad, S Seema, DN Srivastava, GK Pandey et al. Clinical Imaging, 2003, 27: 265-268. (if=0.6, ci=71) 5. Transcatheter arterial embolization in the management of hemobilia. DN Srivastava, S Sharma, S Pal et al. Abd Imaging, 2006, 31(4): 439-448. (if=1.9, ci=64) 6. Inoperable Hepatocellular Carcinoma: Transarterial 188Re HDD – labelled iodized oil for treatment – Prospective Multicenter Clinical Trials. A Kumar, DN Srivastava, TTM Chau et al. Radiology, 2007, 243(2): 509 – 519. (if=6.2, ci=50) 7. Radiofrequency ablation of liver metastases from breast cancer: results in 14 patients. G Gunabushanam, S Sharma, S Thulkar, DN Srivastava, GK Rath et al. J Vasc Interv Radiol 2007, 18: 67 – 92. (if=2.1, ci=43) 8. Radiological evaluation of covered self-expandable metallic stents used for palliation in patients with malignant esophageal strictures. Z Neyaz, DN Srivastava, S Thulkar, S Bandhu, S Gamangatti et al. Acta Radiologica, 2007, 2: 156 – 1 (if=1.3, ci=18) 9. Imaging the inferior vena cava: a road less traveled. H Kandpal, R Sharma, S Gamangatti, DN Srivastava and S Vashisht. Radiographics 2008; 669 – 689. (if=2.6, ci=105) 10. Clinical impact of multidetector row computed tomography before bronchial artery embolization in patients with hemoptysis: a prospective study. M Gupta, DN Srivastava, A Seith, S Sharma et al. Can Assoc Radiol J, 2013 64(1): 61-73. (if=0.5, ci=12)

370

VALECHA, NEENA (b 1957), Director, National Institute of Malaria Research (ICMR), Delhi

Member of the NASI: Yes (YON 2016, Medical & Forensic Sciences)

Dr. Neena Valecha, M.D., F.A.M.S., an accomplished scientist with international reputation of excellence in malaria and clinical pharmacology is Director of the National Institute of Malaria Research of ICMR. Malaria drug policy of India revolves around her work on drug development and drug resistance studies. Dr. Valecha initiated Nationwide sentinel system with NVBDCP for monitoring antimalarial drug resistance. She introduced pharmacovigilance programme for antimalarials. Oral artemisinin monotherapy was phased out from India based on evidence generated by her. She spearheaded the GCP trials of antimalarials in India. Her work has led to introduction of new antimalarials, namely alpha- beta arteether in the programme, registration of novel antimalarials bulaquine, fixed dose combinations namely artesunate-mefloquine, artesunate-amodiaquine, DHA-piperaquine and arterolane-piperaquine. Her leadership led to recognition of NIMR as WHO accredited lot testing laboratory for malaria Rapid Diagnostic Tests. She led studies on treatment and prevention of malaria in pregnancy and malaria disease burden in India. She is conducting Comprehensive Case Management project, which will lead the path to malaria elimination. Her leadership guides the research on development of novel vector control tools and insecticide resistance monitoring and innovative technology for control for dengue. She represents India in the Malaria Policy Advisory Committee, which is the highest committee providing independent advice to WHO. She is also a member of expert committees of CDSCO, DBT, ICMR, DST etc. She has published more than 130 papers in high impact journals and is recipient of various awards including Dr. M.O.T. Iyengar award for her contributions to malaria research. Proposer: Dr. Soumya Swaminathan, Seconder: Dr. G. B. Nair Ten Best Publications: 1. Valecha N, Savargaonkar D, Srivastava B, Rao BH, Tripathi SK, Gogtay N, Kochar, SK, Kumar NB, Rajadhyaksha GC, Lakhani JD, Solanki BB, Jalali RK, Arora S, Roy A, Saha N, Iyer SS, Sharma P, Anvikar AR. 2016. Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study. Malar. J.15, 42. (if=3.109, ci=0) 2. Mishra N, Prajapati SK, Kaitholia K, Bharti RS, rivastava B, Phookan S, Anvikar AR, Dev V, Sonal GS, Dhariwal AC, White NJ, Valecha N. 2015. Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker. Antimicrob Agents Chemother. 59, 5:2548-53. (if=4.476, ci=3) 3. Singh R, Savargaonkar D, Bhatt R M, Valecha N. 2013. Rapid detection of Plasmodium vivax in saliva and blood using loop mediated isothermal amplification (LAMP) assay. Journal of Infection, 67, 3, 245- 247. (if=4.441, ci=7) 4. Mishra N, Singh JP, Srivastava B, Arora U, Shah NK, Ghosh SK, Bhatt RM, Sharma SK, Das MK, Kumar A, Anvikar AR, Kaitholia K, Gupta R, Sonal GS, Dhariwal AC, Valecha N. 2012. Monitoring antimalarial drug resistance in India via sentinel sites: outcomes and risk factors for treatment failure, 2009-2010. Bull World Health Organ, 90, 12, 895-904. (if=5.250, ci=15) 5. Shah N K, Dhillon GPS, Dash AP, Arora U, Meshnick R Steven and Valecha N. 2011. Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space. Lancet Infect Dis. 11, 1, 57- 64. (if=15.583 , ci=65) 6. Valecha N, Looareesuwan S, Mårtensson A, Abdulla SM, Krudsood S, Tangpukdee N, MohantyS, Mishra SK, Tyagi PK, Sharma SK, Moehrle J, Gautam A, Roy A, Paliwal J K, Kothari M, Saha N, Dash AP, Björkman A. 2010. Arterolane, a New Synthetic Trioxolane for Treatment of Uncomplicated P. falciparum Malaria: A Phase II Multicentric Randomized Dose Finding Clinical Trial. Clin Infect Dis, 51: 684-691. (if=8.195, ci=41) 7. Valecha N, Phyo AP, Mayxay M, Newton PN, Krudsood S, Keomany S, Khanthavong M, Pongvongs T, Ruangveerayuth R, Uthaisil C, Ubben D, Duparc S, Bacchieri A, Corsi M, Rao BHK, Bhattacharya PC, Dubhashi N, Ghosh SK, Dev Vas, Kumar A, Pukittayakamee S. 2010. An open-label, randomised study of Dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.PLoS one, 5, 7. (if=4.351, ci=48) 8. Valecha N, Srivastava P, Mohanty SS, Mittra P, Sharma SK, Tyagi PK, Pradhan K, Dev V, Singh R, Dash AP, Sharma YD. 2009. Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India. Malaria J, 8,107 (2009). (if=3.002, ci=44) 9. Valecha N, Joshi H, Mallick PK, Sharma SK, Kumar A, Tyagi PK, Shahi B, Das MK, Nagpal BN, Dash AP. 2009. Low efficacy of chloroquine: Time to switch over to artemisinin-based combination therapy for falciparum malaria in India. Acta Trop, 111, 1, 21–28 (2009). (if=2.221, ci=28) 10. Valecha N, Sharma VP, Devi CU. 1998. A Rapid Immunochromatographic Test (ICT) for Diagnosis of Plasmodium falciparum. Diagn Microbiol Infect Dis ,30, 257-260 (1998). (if=2.913, ci=30)

371

BANERJEE, MONISHA (b 1965), Professor, University of Lucknow, Lucknow

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr. Monisha Banerjee developed DNA diagnostic methods for genetic disorders like hearing loss, achondroplasia, myopathies etc. and established a manual sequencing technique for mutation detection, carrier analysis and prenatal diagnosis of Duchenne/Becker muscular dystrophy, spinal muscular atrophy and Hemophilia A to provide dependable genetic counseling to affected families (AmJMedGenet,2001,101:198-202; EurUrol,2002,41:318-322; IntJMolMed,2002,9:91-94; ExpMolMed, 2003,35:113-117; Perinatology,2004,6:221-230). Further, she identified genetic variants of different pathways in type 2 diabetes (T2DM) and cervical cancer (CaCx) and established risk genotypes/haplotypes associated with T2DM and CaCx in North Indian population. This led to identification of several risk alleles associated with individual susceptibility to T2DM and CaCx which will greatly help in designing pharmacogenetics-guided preventive and therapeutic measures (IntJDiabMellitus,2010,2:179-183; DiabTechTherap,2013,15(8):680-687; IntJBiomedRes,2013,04:655- 662; EurJObsGynecolReprodBiol,2014,176:68-74; FreeRadRes,2015,49(1):17–24; Genet Test Mol Bioma, 2015,19(3):144-149). She found that in CaCx women, association of GSTM1 null genotype with GSTP1 AG+GG polymorphism greatly reduced the hazard ratio which means a better overall survival after chemoradiation therapy. The inter-individual difference in differential activity of GST enzymes has impact on treatment outcome i.e. survival of women suffering from CaCx (PLoS ONE,2015,10(11):e0142501). Dr. Monisha has also made significant contribution in another aspect of human genetics i.e. prenatal diagnosis of genetic disorders. She has successfully established a kit based Nucleospin method for isolation of cell free fetal DNA (cffDNA) from maternal plasma in considerable quantities and correlate with various pregnancy related complications such as preeclampsia and gestational diabetes (ISRN Genetics,2013(2013),Article ID 961293; AnnalsBiolRes,2011,2(6):155-164) and thereby develop a non-invasive method of obtaining fetal DNA from maternal circulation for prenatal diagnosis of genetic disorders. Proposer: Dr. P. Kalpana Murthy, Seconder: Dr. Shailja Bhattacharya Ten Best Publications: 1. Kumar R, Mukherjee M, Sidhu H, Bhandari M, Mittal RD (2002). Role of Oxalobacter formigenes in calcium oxalate stone disease: A study from North India. European Urology, 41: 318-322. (if=13.938, ci=93) 2. Mukherjee M, Chaturvedi LS, Srivastava S, Mittal RD, Mittal B. de novo mutations in sporadic deletional Duchenne muscular dystrophy (DMD) cases (2003). Experimental and Molecular Medicine, 35(2): 113-117 (if=3.446, ci=29) 3. Bid HK, Konwar R, Saxena M, Agarwal CG, Banerjee M (2009). Vitamin D receptor (VDR) gene (Fok I, Taq I, BsmI) polymorphisms related with type-II diabetes mellitus in North Indian population. Indian Journal of Medical Science, 63(5): 187-194. (if=1.67, ci=64) 4. Gautam S and Banerjee M. The Macrophage Ox-LDL receptor, CD36 and its association with type II diabetes mellitus. Molecular Genetics and Metabolism (2011), 102(4): 389-398. (if=2.625, ci=32) 5. Banerjee M and Saxena M (2012). Interleukin-1 (IL-1) family of cytokines: Role in type 2 diabetes. Clinica Chemica Acta, 413: 1163–1170. (if=2.824, ci=69) 6. Tabassum R, Chauhan G, Dwivedi OP…….Saxena M, Banerjee M…………Basu A, Scaria V, McCarthy M, DIAGRAM, INDICO, Venkatesan R, Mohan V, Tandon N, Bharadwaj D (2013). Genome wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes, 62: 977-986 (if=8.474, ci=64) 7. Banerjee M and Vats P (2014). Reactive metabolites and antioxidant gene polymorphisms in type 2 diabetes mellitus. Redox Biology, 2: 170-177. (if=1.294, ci=33) 8. Abbas M, Srivastava K, Imran M, Banerjee M (2014). Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in North Indian population. European Journal of Obstetrics & Gynecology and Reproductive Biology, 176: 68-74(if=1.695, ci=07) 9. Vats P, Sagar N, Singh TP, Banerjee M (2015). Association of superoxide dismutases (SOD1 and SOD2) and Glutathione peroxidase 1 (GPx1) gene polymorphisms with Type 2 diabetes mellitus. Free Radical Research, 49(1): 17–24 (if=2.976, ci=06) 10. Abbas M, Kushwaha VS, Srivastava K, Banerjee M (2015). Glutathione S-Transferase gene polymorphisms and treatment outcome in cervical cancer patients under concomitant chemoradiation. PLoS ONE, 10(11): e0142501. doi:10.1371/journal. pone.0142501(if=3.23, ci=not yet)

372

DAS, KUSAL KANTI (b 1962), Professor of Physiology, BLDE University’s Shri B.M.Patil Medical College, Hospital & Research Centre, Vijayapur-586103, Karnataka,India

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Kusal K Das is personally known to me as a researcher in the similar area of my research interest. He has made significant contribution to our understanding of experimentally induced hypoxia & cell signaling mechanism during heavy metal induced stress and alteration of vascular integrity using animal as well as human models. His researches showed the link between the divalent heavy metals (Pb and Ni) and oxygen sensing mechanisms through hypoxia-inducible factor-1α (HIF-1α) that regulate sympathetic overdrives and ROS generation. Currently he is working on the HIF-1 α dependent responses to hypoxia along with calcium channel blockers and vitamin C supplementation in vascular responses to ischemia that are associated with aging, diabetes and other cardiovascular disorders (Das KK et al 2016). Further, contribution of the nominee in developing a method for estimating blood vitamin E levels is noteworthy. Equally important is the standardization of a ‘stroke model’ in rodents to understand strokes and treatment of patients. He is among the first in the world to establish the link between arsenic toxicities and gold mining activities which made a significant impact on Indian Government policy on environmental issues. His researches thus range from experimental physiology to clinical medicine. Prof.Das is a recipient of “Dr. State Award for Scientist 2013” by KSCST, Government of Karnataka and the recipient of “Science, Honor & Truth Medal 2016” by Bolivian Medical Academy, Bolivia. He is a Visiting Professor (2017-2018) at Tulane University School of Medicine, New Orleans, USA. Proposer: Prof. Srinivas K. Saidapur, Seconder: Prof. N.M.Bujurke Ten Best Publications: 1. Ugran V,Desai N, Chakraborti D,Masali KA,Mantur P, Das SN,,Guggarigoudar SP, Vallabha T,Patil SS,Das KK (2016).Environmental Geochemistry and Health 2016; .pp 1-13. DOI: 10.1007/s10653-016- 9869-2 (if=2.12, ci=03) 2. Das KK, Razzaghi-Asl N.; Tikare SN, Di Santo R, Costi R; Messore A; Pescatori L; Crucitti GC; Jargar JG; Dhundasi SA; Saso L.(2016).J Enzyme Inhibition Med Chem ; 31(1):99-105 (if=2.332, ci=04) 3. Patil SG, Aithala MR, Das KK.(2015). Complement Ther Med.;23(4):562-569 (if=2.22, ci=05) 4. Hattiwale SH, Saha S, Yendigeri SM, Jargar JG, Dhundasi SA, Das KK (2013). Biometals, 26(2), 329- 336 (if=3.284, ci=11) 5. Chakraborti D, Rahman MM, Murrill M, Das R, Siddayya, Patil SG, Sarkar A, Dadapeer H J, Yendigeri SM, Ahmed R, Das KK. (2013).J Hazard Mater; 15; 262:1048-55 (if=4.836, ci=15) 6. Das KK, Das SN, Dhundasi SA.(2008).Indian J Med Res; 128(4):412-25 (if=1.446, ci=210) 7. Gupta AD, Das SN, Dhundasi SA, Das KK(2008).Int J Environ Res Public Health ; 5(3):147-51 (if=2.79, ci=78) 8. Das KK, Gupta AD, Dhundasi SA, Patil AM, Das SN, Ambekar JG.(2007).Biometals; 20(2):177-84 (if=3.284, ci=34) 9. Patil AJ, Bhagwat VR, Patil JA,Dongre NN, Ambekar JG, Jailkhani R, Das KK.(2006).Int J Environ Res Public Health ; 3(4):329-37 (if=2.79, ci=76) 10. Das KK, Dasgupta S.(2002).Environ Health Perspect; 110(9):923-6 (if=8.44, ci=56)

373

DAS, SANJEEV (b 1976), Staff Scientist-V, National Institute of Immunology, New Delhi

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

The major scientific contributions of Dr. are in the field of cancer biology. Dr. Das has worked extensively on understanding the regulatory milieu of tumor suppressors, the proteins that regulate diverse processes underlying tumorigenesis. The work from his lab has led to a keen understanding of the role of tumor suppressor p53 in metabolic processes (Mol Cell, 2011). They identified PGC-1  (PPAR coactivator-1) as a novel coactivator of p53. Using mass spectrometry based approaches, they explored the p53 interactome. They reported that HDAC5 (Histone Deacetylase 5) deacetylates p53 which suppresses apoptotic functions of p53 in response to chemotherapy (Mol Cell, 2013). Using proteomics approach they also identified novel interacting proteins of the p53 family member p73 that determine its functions and regulation (, 2016). These findings enhance our understanding of the role of p53 family in chemotherapy response. Their studies have also led to the identification of a novel tumor suppressor viz. sirtuin family member SIRT6 in hepatocellular carcinoma (HCC). They demonstrated that SIRT6 suppresses oncogenic potential of PKM2 (Pyruvate kinase M2), a glycolytic enzyme with nuclear protein kinase and transcriptional coactivator functions. Reduced SIRT6 levels correlate with elevated nuclear PKM2 levels in increasing grades of HCC (PNAS, 2016). On the other hand, UBE3A ubiquitylates SIRT6 leading to its proteasomal degradation thereby promoting aggressive tumor phenotype in HCC (Oncogene, 2017). In conclusion, Dr. Das's work highlights the vulnerabilities in tumor cell biology which could be exploited for therapeutic interventions that bring about a positive clinical outcome. Proposer: Prof. , Seconder: Dr. Chandrima Shaha Ten Best Publications: 1. Bhardwaj A, Kohli S and Das S (2017). UBE3A, a key component in dynamic regulation of SIRT6, promotes tumorigenesis in an ANXA2-dependent manner. Oncogene (in press). (if=7.9) 2. Bhardwaj A and Das S* (2016). SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions. Proc Natl Acad Sci USA, 113, E538-E547. (Direct submission) (if=9.6, ci=05) 3. Satija YK and Das S* (2016). Tyr99 phosphorylation determines the regulatory milieu of tumor suppressor p73. Oncogene, 35, 513–527. (if=7.9) 4. Kumari R, Kohli S and Das S* (2014). p53 regulation upon genotoxic stress: Intricacies and Complexities. Molecular and Cellular Oncology, 1, e969653. (if=N.A, ci=02) 5. Kumari R, Sen N and Das S* (2014). Tumor suppressor p53: understanding the molecular mechanisms inherent to cancer. Current Science, 107, 786-794. (if=0.83, ci=01) 6. Sen N, Kumari R, Singh MI and Das S* (2013). HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress. Molecular Cell, 52, 406-420. (Featured Article) (if=14.4, ci=19) 7. Satija YK, Bhardwaj A and Das S* (2013). A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer. International Journal of Cancer, 133, 2759-2768. (if=5.0, ci=26) 8. Sen N, Satija YK and Das S* (2011). PGC-1 a key modulator of p53, promotes cell survival upon metabolic stress. Molecular Cell, 44, 621-634. (Featured Article) (if=14.4, ci=64) 9. Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson SA and Lee SW (2007). Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell, 130, 624-637. (if=29, ci=130) 10. Das S, Ongusaha PP, Yang YS, Park JM, Aaronson SA and Lee SW (2006). Discoidin domain receptor 1 receptor tyrosine kinase induces Cyclooxygenase-2 and promotes chemoresistance through Nuclear Factor- B pathway activation. Cancer Research, 66, 81 (if=8.5, ci=45)

374

DUTTA, RANJNA C (FOR CHHABRA) (b 1966), Indian Institute of Sciences (IISc), Bangalore

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

A bio-medical researcher Ranjna started with the synthesis and evaluation of immunomodulating peptides for targeting liposomes to macrophages, under the supervision of Padamshri Dr. NityaNand at CDRI (1987-93), Lucknow and ended up joining hands with her husband Dr. A.K. Dutta, as founder Director of ExCel-Matrix Biological Devices P Ltd, India’s first and perhaps the only innovation based company in Tissue Engineering and Regenerative Medicine in 2005-06. Ranjna was associated with NII and ICGEB New Delhi (1994-99), IICT (1999-02) and NIN (2009-12), Hyderabad for different projects, collaborative as well as her own and with Northwestern University, Illinois, USA (2002-03) as visiting post-doctoral fellow. She received ‘Prolog to Discovery’ award at IICT for her innovative project and also published 19 papers in International Journals (IF >50; with >316 citations). Ranjna is an invited member of ‘American Nano-society’ and editorial board of ‘Austin J. of Molecular & Cellular Biology’. She has contributed as managing editor of special issue on ‘Cell Dynamics in 3D culture’ in ‘Frontiers in Biosciences’. Lately she has been engaged in the design and synthesis of novel, ECM-mimicking macro-conjugates for creating instructive 3D-scaffolds that in addition to TE & RM can find applications in therapeutic delivery. Knowing the challenges of Biotechnology start-ups in the country, I find her work extremely valuable for translation of new technologies in tissue engineering and regenerative medicine. In view of her significant contributions to the field of Medical Biotechnology, I enthusiastically recommend Dr. Ranjna C. Dutta to be elected as a fellow of NASI. Proposer: Prof. , Seconder: Dr. G. Bhanuprakash Reddy Ten Best Publications: 1. S. P. Singh, R. Chhabra and V. M. L. Srivastava, (1992) Respiratory burst in peritoneal exudate cells in response to a modified tuftsin, Experientia (now Cellular & Molecular Life Sciences) , 48(10): 994-996. (if= 5.808, ci= 11) 2. G. P. Talwar, S. Shah, S. Mukherjee and R. Chhabra, (1997) Induced termination of pregnancy by purified extracts of Azadirachta indica (Neem): Mechanisms involved, Am J Reproductive Immunol 37(6): 485-491. (if= 3.32, ci= 42) 3. Ranjna C. Dutta, A. Puri and N. Anand, (2001) The Immunomodulatory potential of hydrophobic analogues of rigin and their role in providing protection against Plasmodium berghei infection in mice, Int Immunopharm 1: 843-855. (if= 2.472, ci= 10) 4. Ranjna C Dutta, (2002) Peptide immunomodulators versus infection: an analysis. Immunol Letters 83: 153-161. (if= 2.512, ci= 24) 5. Ranjna C. Dutta, (2007) Drug Carriers in Pharmaceutical Design; Promises and Progress Curr Pharm Design 13: 761-769. (if= 3.452, ci= 42) 6. Ranjna C. Dutta, Sushma Nagpal and Dinakar M. Salunke, (2008) Functional mapping of apidaecin through secondary structure correlation, Int J Biochem & Cell Biol 40: 1005-1015. (if= 4.046, ci= 17) 7. Ranjna C. Dutta and Erwin Goldberg, (2008) Testis specific LDH as target for immunoliposome, Am J Reproductive Immunol 60: 26-32. (if= 3.32, ci= 7) 8. Ranjna C. Dutta and Aroop K. Dutta, (2009) Cell interactive 3D scaffold; advances and applications. Biotech Advances 27: 334-339.(if= 9.015, ci= 116) 9. Ranjna C. Dutta and Aroop K. Dutta, (2010) Comprehension of ECM-Cell dynamics: A prerequisite for tissue regeneration, Biotech Advances 28: 764-769. (if= 9.015, ci= 25) 10. Ranjna C. Dutta and Aroop K. Dutta, (2012) ECM analog technology for 3D cell culture, Frontiers in Bioscience (Scholar/Elite Ed), 4:1043-1048. (if= 3.523, ci= 1)

375

GANGADHAR, BANGALORE NANJUNDAIAH (b 1955), Professor of Psychiatry & Director, National Institute of Mental Health And Neurosciences, Bengaluru

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Prof. Gangadhar brings over 30 years of clinical research in the field of mental health. His research interests are Electroconvulsive Therapy (ECT), Schizophrenia, Public Health and Yoga. He has successfully guided over 50 MD and PhD scholars. He has more than 350 research publications (H- Index-37;RG Score-45.08). In 1990s, he developed indigenous, state-of-the-art ECT machine. His research findings on stimulus, electrode applications, its strength, anaesthetic standards and clinical/physiological monitoring in ECT have contributed to safer ECT procedure. He developed paperless EEG feature and simple signal-processing algorithms to quantitate EEG-seizure that has potential for assessing clinical potency of ECT. His work in setting standards for ECT practice led him to be involved in review of the ECT guidelines of the APA in 2000. The ECT manual that he wrote saw a second edition and is popular among clinicians. Dr. Gangadhar has standardized applications of generic Yoga practices for therapeutic uses in psychiatric disorders like schizophrenia, depression, OCD, mild cognitive impairment and ADHD. His papers on use of Yoga in schizophrenia and depression are widely cited. This has also influenced the UK guidelines (NICE) to recommend yoga as an adjunct in Schizophrenia. The yoga research from his team demonstrated the neurotropic effects of yoga. The research is expected to bring yoga into the main stream of clinical practice in psychiatry. The department of science and technology, therefore, invited him to lead the review team of SATYAM, a scheme to support advanced yoga research in the country. Proposer: Prof. Vijayalakshmi Ravindranath, Seconder: Prof. V. Nagaraja Ten Best Publications: 1. Gangadhar BN, Kapur RL and Kalyanasundaram S. 1982. Comparison of electroconvulsive therapy with imipramine in endogenous depression: a double blind study. The British journal of psychiatry : the journal of mental science. 141:367-71. (if=7.06, ci=128) 2. Gangadhar BN, Ancy J, Janakiramaiah N and Umapathy C. 1993. P300 amplitude in non-bipolar, melancholic depression. Journal of affective disorders. 28(1):57-60. (if=3.57, ci=122) 3. Radhakrishnan N and Gangadhar BN. Estimating regularity in epileptic seizure time-series data. 1998. A complexity-measure approach. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology So (if=26.303, ci=188) 4. Janakiramaiah N, Gangadhar BN, Naga Venkatesha Murthy PJ, Harish MG, Subbakrishna DK and Vedamurthachar A. 2000. Antidepressant efficacy of Sudarshan Kriya Yoga (SKY) in melancholia: a randomized comparison with electroconvulsive therapy (ECT) and im (if=3.57, ci=363) 5. Jayakumar PN, Venkatasubramanian G, Gangadhar BN, Janakiramaiah N and Keshavan MS. 2005. Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia. Progress in neuro-psychopharmacology & biological ps (if=4.36, ci=93) 6. Vedamurthachar A, Janakiramaiah N, Hegde JM, Shetty TK, Subbakrishna DK, Sureshbabu SV and Gangadhar BN. 2006. Antidepressant efficacy and hormonal effects of Sudarshana Kriya Yoga (SKY) in alcohol dependent individuals. Journal of affective disorder (if=3.57, ci=128) 7. Duraiswamy G, Thirthalli J, Nagendra HR and Gangadhar BN. Yoga therapy as an add-on treatment in the management of patients with schizophrenia--a randomized controlled trial. 2007. Acta psychiatrica Scandinavica. 2007; 116(3):226-32. (if=6.128, ci=231) 8. Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN and Shetty KT. 2007. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. The American journal of psychiatry. 164(10):1 (if=13.505, ci=173) 9. Udupa K, Sathyaprabha TN, Thirthalli J, Kishore KR, Lavekar GS, Raju TR and Gangadhar BN. 2007. Alteration of cardiac autonomic functions in patients with major depression: a study using heart rate variability measures. Journal of affective disorders (if=3.57, ci=150) 10. Mehta UM, Thirthalli J, Subbakrishna DK, Gangadhar BN, Eack SM and Keshavan MS. 2013. Social and neuro-cognition as distinct cognitive factors in schizophrenia: a systematic review. Schizophrenia research. 148(1-3):3-11. (if=4.453, ci=53)

376

GARG, PANKAJ (b 1972), Senior Surgeon Colorectal & Laparoscopic, Fortis Super Hospital, Mohali

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr Garg a renowned Surgeon of international fame. He is one of the rare clinicians in the country who has invented 4 new operations (PERFACT, Tube in tract, LOCULA, FATS) to treat complex dreaded illnesses. PERFACT procedure is quite effective to treat highly complex fistula-in-ano, a disease for which there is no good treatment available. (Published in highest ranking Colorectal journal in world: Impact factor - 3.75). Presentations (>60) in top US & European conferences. Consecutive invitations for last 8 years from Top American Surgical Societies to give lectures. Surgeons from across the globe are coming to him to learn the procedures he has invented. He is also teaching clinical research to medical students from all over the world. Dr Garg has two discoveries to his credit. He discovered that water-jet stream used in toilet commodes could cause anterior fissure-in-ano. This discovery would help prevent this painful disease in large number of people. He has also innovated three New treatment concepts (TONE, LOABAC & ECLIPs). With Dr Garg’s new treatments, TONE & LOABAC (Published in highest ranking Colorectal journal in world), a large proportion of these operations can be averted in lakhs of people and save enormous resources. He is bestowed with the highest award in the field of Science & Technology in states of Haryana, Punjab & Chandigarh and top surgical societies of world (SAGES-USA, ASCRS-USA, ASI-India). Hundreds of patients from 30 countries came to Panchkula (Chandigarh) to get treated by him [not for cheaper treatment (medical tourism), but for his technical expertise]. Proposer: Dr. Javed N. Agrewala, Seconder: Prof. I.B.S. Passi Ten Best Publications: 1. Jagat Narula, Pankaj Garg, Stephen Achenbach, Sadako Motoyama, Renu Virmani,William Strauss. 2008. Arithmetic of Vulnerable Plaques for Noninvasive Imaging.Nature Clinical Practice Cardiovascular Medicine. 5:, S1-9 (if=9.18, ci=121) 2. Pankaj Garg. 2009. Lichtenstein Hernioplasty Versus Totally Extraperitoneal Laparoscopic Hernioplasty in treatment of Recurrent Inguinal Hernia-A Prospective Randomized Trial. Annals of Surgery Sep;250(3):504. (Highest ranking Surgery Journal in the world)(if=8.32, ci=65) 3. Pankaj Garg. 2016. Why should a good proportion of Hemorrhoids not be operated? – Let’s TONE up. Diseases Colon Rectum (Being Published)(Highest ranking Colorectal Surgery Journal in the world) (if=3.75, ci=Being Published) 4. Pankaj Pankaj Garg, Pratiksha Singh. 2016. Post defecation cleansing methods: Tissue paper or water? An analytical review.Diseases Colon Rectum (Being Published) (Highest ranking Colorectal Surgery Journal in the world) (if=3.75, ci= (Being Published)) 5. Pankaj Garg, Mahesh Rajgopal, Vino Varghese, Mohamed Ismail. 2009. Laparoscopic total extraperitoneal inguinal hernia repair with non fixation of the mesh in 1692 hernias. Surgical Endoscopy 23:1241-5 (Highest ranking Laparoscopic Surgery Journal in the world)(if=3.26, ci=52) 6. Pankaj Garg, Geetha R Menon, Mahesh Rajgopal, Mohamed Ismail. 2010. Laparoscopic total extraperitoneal repair in recurrent inguinal hernias.Surgical Endoscopy 24(2):450-4 (Highest ranking Laparoscopic Surgery Journal in the world) (if=3.26, ci=20) 7. Pankaj Garg, Mohamed Ismail. Horizontal mattress suture at Garg Pankaj, Nair S, Shereef M, Thakur JD, Nain N, Menon GR, Ismail M. 2011. Mesh fixation compared to nonfixation in total extraperitoneal inguinal hernia repair: a randomized controlled trial in a rural center in India. Surgical Endoscopy 25(10):3300-6 (Highest ranking Laparoscopic Surgery Journal in the world) (if=3.26, ci=19) 8. Pankaj Garg, Jai Deep Thakur, Mahak Garg, Geetha Menon. 2012. Single-incision laparoscopic cholecystectomy vs. conventional laparoscopic cholecystectomy : A meta-analysis of randomized controlled trials. Journal of Gastrointestinal Surgery 16(8):1618-28(if=2.80, ci=76) 9. Pankaj Garg, Mahak Garg. 2015. Perfact procedure: A new concept to treat highly complex anal fistula. World J Gastroenterology 21(13): 1-10 (New Operation Invented by Dr Garg) (if=2.39, ci=2) 10. Pankaj Garg, Jeremy Song, Amarjit Bhatia, HemantKalia, Geetha Menon. 2010. The efficacy of Anal Fistula Plug in Fistula-in-ano: A systematic review. Colorectal Disease 12(10):965-70 (if=2.35, ci=102)

377

GHATAK, ASHIM (b. 1957) Chief Scientist & Head & Professor, AcSIR, Division of Clinical & Experimental Medicine, Central Drug Research Institute, Lucknow

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr. Ashim Ghatak is among the few clinical scientists of the country who have made significant contribution to basic sciences. His elucidation of pathophysiology of heart diseases– a definitive role of increased oxidative stress in ischemic heart patients, which attenuates with Vitamin E 400 mg daily orally in addition to standard treatment in the first few days in acute myocardial infraction and an important role of oxidative stress and serotonin in heart failure, where standard treatment along with vitamin E 400 mg daily orally for 4 weeks significantly improves the congestive heart failure. He has also elucidated the Nitric Oxide pathways in Essential Hypertension and shown a reversible suppression of Nitric Oxide with standard treatment along with vitamin E orally . He has also recently identified newer Biomarkers for lifestyle diseases especially in metabolic syndrome and various cancers . Dr. Ghatak has been planning, conducting and coordinating phase- I to IV clinical trials of CDRI drugs – Centchroman, Gugulipid, injection α-β arteether& CDRI 80/53 and these have been successfully marketed . He has conducted and coordinated clinical trials of other CDRI candidate drugs. His publications which have been cited widely - Google Scholar-330 citations & h-index-7; and Web of Science -122 citations & h-index-3 and has been awarded and recognized by his peers . He has successfully filed many national and international patents. He has been responsible for the implementation of Good Clinical Practices and important Ethical issues in CDRI . Proposer : Dr. B.N. Dhawan, Seconder : Dr. V.P. Kamboj Ten Best Publications : 1. Ghatak, A; Brar, MJS; Agarwal, A; Goel, N; Rastogi, AK; Vaish, AK; Sircar, AR; Chandra, M ; 1996; Oxy free radical system in heart failure and therapeutic role of oral vitamin E; INTERNATIONAL JOURNAL OF CARDIOLOGY; 57 (2); 119 -127. IF=4.036 WoS CI =63 GS CI=109 2. Chandra, M; Chandra, N; Agrawal, R; Kumar, A; Ghatak, A; Pandey, Vc ;1994; The Free-Radical System In Ischemic-Heart-Disease; INTERNATIONAL JOURNAL OF CARDIOLOGY; 43 (2) 121- 125. IF=4.036 WoS CI =43 GS CI=65 3. Gupta, RR; Agrawal, CG; Singh, GP; Ghatak A ; 1994; A Lipid-Lowering Efficacy Of Psyllium Hydrophilic Mucilloid In Non-Insulin-Dependent Diabetes-Mellitus With Hyperlipidemia. INDIAN JOURNAL OF MEDICAL RESEARCH, , 100, 237 -241. IF=1.396 WoS CI =16 GS CI=51 4. A Ghatak, OP Asthana; 1995; Recent trends in hyperlipoproteinemias and its pharmacotherapy., INDIAN JOURNAL OF PHARMACOLOGY 27 (1) 14. IF=0.691 GS CI=43 5. PA Sadiq, A Puri, M Dikshit, A Ghatak, SK Dwivedi, VS Narain, RK Saran ; 2005 ; Profile And Prevalence Of Aspirin Resistance In Indian Patients With Coronary Artery Disease, ... INDIAN HEART JOURNAL; 57 , 658- 661. GS CI=32 6. M Chandra, K Surendra, RK Kapoor, A Ghatak, G Kaur, NR Pandey; 2000; Oxidant stress mechanisms in heart failure... BOLLETTINO CHIMICO FARMACEUTICO, 139 (3), 149. GS CI=11 7. OP Asthana, JS Srivastava, A Ghatak, SPS Gaur, BN Dhawan ; 1996; Safety and tolerability of bacosides A and B in healthy human volunteers; INDIAN JOURNAL OF PHARMACOLOGY, 28 (10) 37. IF=0.691 GS CI=8 8. VV Bhosale, SC Inamdar, VB Karande, SR Burute, MB Murthy, A Ghatak ; 2014; Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension; JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH ; 8 (6) ;HC01 -HCO4. GS CI=4 9. G Monte, RP Moerschell, A Ghatak, E Melissari; 1993; C4b-Binding Protein -An Update.; THROMBOSIS AND HAEMOSTASIS ; 69(1)86. IF=4.984 GS CI=3 10. AK Vaish, S Kumar, M Chandra, A Ghatak, AK Balapure, AR Sircar ; 2001; Effect of ALPHA- Tocopherol on oxidative stress and antioxidant enzymes in essential hypertension., JOURNAL OF INTERNAL MEDICINE OF INDIA; 4 55- 57 GS CI=2

378

KALIMUTHUSAMY, NATARAJASEENIVASAN (b 1968), Professor of Microbiology, Bharathidasan University, Tiruchirappalli

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Prof. K. Natarajaseenivasan has made outstanding contribution in leptospirosis, an under-diagnosed serious life threatening disease of low socio-economic population from coastal regions of India. He has identified and characterized several in vivo expressed immunoreactive clones from the gene expression library of L. interrogans serovar Autumnalis strain N2. With the advent of these immunoreactive proteins, the effort was culminated with the evaluation and development of a highly reliable diagnostic technique for acute leptospirosis. Extensive computational prediction was performed to identify immunogenic peptides of the predominant leptospiral immunoglobulin like protein (LigA). The predicted peptides were chemically synthesized and utilized in a peptide based IgM ELISA diagnostic format and also for the production of monoclonal antibodies to develop an antigen detection system for conclusive diagnosis of leptospirosis and also to identify the carrier status. The breakthrough in his research career was to develop an alternative strategy for the most cumbersome microscopic agglutination test (MAT) for diagnosis of leptospirosis by developing LPS serogroup specific immunochromatography based lateral flow assay (ICG-LFA) (PLOS ONE, 2015). In addition, the leptospiral isolates recovered from two different geographical settings were genotyped using MLST and identified new genetic variations in sucA and pfkB loci. His group also established host pathogen interactions with special reference to mitochondrial calcium signaling (Cell Reports, 2014). Besides his pioneering work on leptospirosis, he has also made significant contribution in other research fields including cancer biology, candidiasis and probiotics. I, therefore, strongly support his election to the Fellowship of the Academy. Proposer: Prof. Bhudev C. Das, Seconder: Prof. M. Lakshmanan Ten Best Publications: 1. Kanagavel M, Princy Margreat AA, Arunkumar M, Prabhakaran SG, Shanmughapriya S, Natarajaseenivasan K. Multilocus sequence typing (MLST) of leptospiral strains isolated from two geographic locations of Tamilnadu. Infection, Genetics and Evolution, 2016,37:123-8. (if=3.03) 2. Raja V, Shanmughapriya S, Kanagavel M, Artiushin SC, Velineni S, Timoney JF, Natarajaseenivasan K. In vivo expressed proteins of virulent Leptospira interrogans serovar Autumnalis N2 elicit strong IgM responses of value in early diagnosis. Clinical and Vaccine Immunology, 2015, 23: 65-72. (if=2.5) 3. Vanithamani S, Narayanan R, Raja V, Kanagavel M, Sivasankari K, Shanmughapriya S, Natarajaseenivasan K. Lipopolysaccharide specific immunochromatography based lateral flow assay for serogroup specific diagnosis of leptospirosis. PloS one, 2015, 10(9): e0137130. (if=3.53) 4. Kanagavel M, Shanmughapriya S, Anbarasu K, Natarajaseenivasan K. B cell specific peptides of Leptospira interrogans LigA for the diagnosis of cases with acute leptospirosis. Clinical and Vaccine Immunology, 2014, DOI: 10.1128/CVI.00456-13. (if=2.5) 5. Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang X, Rajan S, Mallilankaraman K, Gandhirajan RK, Vagnozzi RJ, Ferrer LM, Sreekrishnanilayam K, Natarajaseenivasan K, Vallem S, Force T, Choi ET, Cheung JY, Madesh M. MICU1 motifs define mitochondrial calcium uniporter binding and activity. Cell Reports, 2013, 5: 1-13. (if=8.35, ci=32) 6. Shanmughapriya S, Lency AF, Kavitha S, Natarajaseenivasan K. In vitro actinomycetes biofilm development and biofilm inhibition by polyene antibiotic, nystatin on IUD copper surfaces. Biofouling, 2012, 28: 929-935. (if=3.41, ci=3) 7. Shanmughapriya S, Senthilkumar G, Vinodhini K, Das BC, Vasanthi N, Natarajaseenivasan K. Viral and bacterial etiologies of epithelial ovarian cancer. Eur J Clin Microbiol Infect Dis, 2012, 31: 2311- 2317. (if=2.66, ci=19) 8. Shanmughapriya S, Senthil Kumar G, Balakrishnan K, Vasanthi N, Vinodhini K, Natarajaseenivasan K. Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report. BMC Cancer, 2011, 11:218. (if=3.36, ci=1) 9. Natarajaseenivasan K, Artiushin SC, Velineni S, Vedhagiri K, Vijayachari P, Timoney JF. Surface- associated Hsp60 chaperonin of Leptospira interrogans serovar Autumnalis N2 strain as an immunoreactive protein. Eur J Clin Microbiol Infect Dis, 2011, 30: 1383-1389.(if=2.66, ci=5) 10. Natarajaseenivasan K, Vijayachari P, Sharma S, Roy S, Sugunan AP, Biswas D, Sehgal SC. Phylogenetic relatedness among leptospiral strains belonging to same serovar recovered from patients with different clinical syndromes. Infection Genetics and Evolution, 2005, 5: 185-91. (if=3.01, ci=21)

379

KATARE, OM PRAKASH (b 1959), Professor (Pharmaceutics), University Institute of Pharmaceutical Sciences, Director, Research Promotion Cell (RPC), Panjab University

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

A drug delivery expert par excellence, Professor Katare is recognized globally as an accomplished scientist in the sphere of Liposome Technology, with more than 120 International and National research publications, several book chapters and patents (5 granted out of 18 filed). He guided successfully as many as 10 Ph.D. thesis and completed several ambitious research projects. But, the hallmark of Prof. Katare’s work relates to Academia-Industry collaborative ventures which, to be rated very high, culminated into the tech transfers and commercialization of the cutting-edge technologies. The three novel liposome and nanotechnology based pharmaceutical products (Psorisome™, Lipotar S™, Lipotar SS™) for the treatment of ‘difficult-to-treat’ skin ailment, Psoriasis, are in the market. For this contribution, Prof. Katare has received high-end awards and accolades including DBT National Technology Award by the then President of India, (Late) Dr A P J Abdul Kalam (2007), IABMS Best Patent Award (2012), OPPI Scientist Award (2011), and Illustrious Alumnus Award (2016) by Dr H S Gaur Vishwavidyalaya etc. Currently, after holding several prestigious University positions, he is serving as Director, Research, Panjab University and engaged himself intensively and extensively in formulating research plans and policies. In a nutshell, the collaborative efforts of Prof. Katare in the field of translational research comprising both basic and applied sciences has contributed substantially in creating the culture and climate for the current and younger generation. Proposer: Dr. P.K. Chakraborti, Seconder: Prof. Arun Kumar Grover Ten Best Publications: 1. Agarwal R., Katare O. P. and Vyas S. P. 2001. Preparation and In-Vitro Evaluation of Liposomal/Niosomal Delivery Systems of Antipsoriatic Drug Dithranol. International Journal of Pharmaceutics 228(1-2), 43-52. (if=4.01, ci=200) 2. Kumar R. and Katare O. P. 2005. Lecithin Organogels as a Potential Phospholipid Structured System for Topical Drug Delivery: A Review. AAPS PharmSciTech 6 (2), E298-E310. (if=1.64, ci=169) 3. Raza K., Singh B., Singal P., Wadhwa S. and Katare O.P. 2013. Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne. Colloids and Surfaces B: Biointerfaces 105C, 67-74 (if=4.4, ci=53) 4. Bhatia A., Kumar R. and Katare O. P. 2004 Tamoxifen Entrapped Topical Liposomes: Development, Characterization and In-Vitro Evaluation. Journal of Pharmacy and Pharmaceutical Sciences, S 7(2), 252- 259 (if=1.86, ci=146) 5. Shukla A., Katare O. P., Singh B. and Vyas S. P. 2010. M-cell Targeted Delivery of Recombinant Hepatitis B Surface Antigen Using Cholera Toxin B Subunit Conjugated Bilosomes. International Journal of Pharmaceutics 385(1), 47-52 (if=4.01, ci=48) 6. Madan J., Pandey R.S., Jain V., Katare O.P., Chandra R.and Katyal A. 2013. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine: Nano (if=5.43, ci=54) 7. Raza K., Singh B., Lohan S., Sharma G., Negi P., Yachha Y. and Katare O.P. 2013. Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti- psoriatic activity. International Journal of Phar (if=4.01, ci=55) 8. Raza K., Singh B., Singla S., Wadhwa S, Garg B., Chhibber S. and Katare O.P. 2013. Nanocolloidal carriers of isotretinoin: antimicrobial activity against Propionibacterium acnes and dermatokinetic modeling. Molecular Pharmaceutics 10(5), 19558-63 (if=4.38, ci=15) 9. Jain A., Jain A., Garg N.K., Tyagi R.K., Singh B., Katare O.P., Webster T. And Soni V. 2015. Surface engineered polymeric nanocarriers mediate the delivery of transferrin–methotrexate conjugates for an improved understanding of brain cancer. Acta (if=6.02, ci=7) 10. Bhatia A., Singh B., Raza K., Wadhwa S. and Katare O.P. 2013. Tamoxifen-loaded Lecithin Organogel (LO) for Topical Application: Development, Optimization and Characterization. International Journal of Pharmaceutics 444(1-2), 47-59 (if=4.01, ci=25)

380

KOYAKUTTY, MANZOOR (b 1974), Professor, Amrita Institute of Medical Sciences and Research Centre, AVVP University, Kochi

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr Manzoor Koyakutty has made significant contributions in the multi-disciplinary area of Cancer- nanomedicine. His major contribution was on the emerging field of 'Polypharmaceutical Nanomedicines' where more than one molecules are nanotized together to target multiple signalling mechanisms of cancer. During last 03 years, he secured 07 international patents in this field and published high impact papers (Mol.Pharm.2012,Nanomedicine:NBM2013, May2014, Nov. 2014, ACS Biomater. Sci. Eng., 2015, 2016, Adv. Health Mater.2015, total citations: 4015, h Index: 30). Most importantly, the IPs developed by his team are under translational development by Pharma Industries or DBT/DST, Govt. of India. In a recent work, his team developed a theranostic 3D brain implant that can deliver more than one chemotherapeutics locally in brain over a period of 1-2 months (Nature Sci. Rep., March 2017). This nano-device may help many high grade patients. Other significant contributions include: nanosized photo- and radio-medicines for photodynamic therapy or radiowave hyperthermia. (Nanomedicine:NBM 2010, J. Biomed Nanotechnol. 2014, ACS Biomater. Sci. Eng., 2015, ACS Biomater.Sci.Eng.,2016), Bio-compatible, theranostic nanoparticles to detect cancer cells by MRI-SPECT- NIR imaging (Biomaterials 2010, Biomaterials. 2013, Nanotoxicology, 2012), hand-held raman sensor to detect, classify and grade oral cancer using nanotechnology enabled raman spectral imaging (J.Mater.Chem.B, 2014,2,989). Dr Koyakutty also made significant contribution in the area of toxicology of nanomaterials such as graphene, ZnO and Au clusters (Nanoscale 2011, Small 2012, Advanced Health. Mater., 2013, Nanomedicine: NBM, 2016). Overall, nominee's contributions in the area of novel but affordable cancer-nanomedicines may help many cancer patients in our country. Proposer: Prof. Tapas Kundu, Seconder: Prof. Sathees Raghavan Ten Best Publications: 1. Ranjith Ramachandran,.....,Dilip Panikar, Shantikumar V. Nair & Manzoor Koyakutty, 2017, Theranostic 3-Dimensional nano brain-implant for prolonged and localized treatment of recurrent glioma, Sci. Report (Nature), doi:10.1038/srep43271, 2017 (if=5.22, ci=New paper, March 2017) 2. S Setua, D Menon, A Asok, S Nair, Manzoor Koyakutty,2010, Folate receptor targeted, rare-earth oxide nanocrystals for bi-modal fluorescence and magnetic imaging of cancer cells,Biomaterials, 31 (4), 714 (if=8.387, ci=161) 3. A Ashokan, D Menon, S Nair, Manzoor Koyakutty,2010 A molecular receptor targeted hydroxyapatite nanocrystal based multi-modal contrast agent, Biomaterials 31 (9), 2606 , (if=IF: 8.387, ci=76) 4. A Sasidharan, P Chandran, D Menon, S Raman, S Nair, Manzoor Koyakutty, 2011, Rapid dissolution of ZnO nanocrystals in acidic cancer microenvironment leading to preferential apoptosis, Nanoscale 3 (9), 3657-3669 (if= IF: 7.394, ci=60) 5. CM Girish, A Sasidharan, GS Gowd, S Nair, Manzoor Koyakutty, 2013, Confocal Raman imaging study showing macrophage mediated biodegradation of graphene in vivo, Adv. Health Mater., 2 (11), 1489, (if=5.76, ci=40) 6. Sasidharan A, Panchakarla LS, Chandran P, Menon D, Nair S, Rao CN, Manzoor Koyakutty, 2011, Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene., Nanoscale 3(6):2461 (if=IF: 7.394, ci=193) 7. A Sasidharan, LS Panchakarla, AR Sadanandan, A Ashokan, Shanti Nair, Manzoor Koyakutty, 2012, Hemocompatibility and macrophage response of pristine and functionalized graphene, Small,8 (8), 1251 (if=8.315, ci=128) 8. Ashokan A, Gowd GS, Bhupathi A, Peethambaran R, Unni AK, Palaniswamy S, Nair SV, Manzoor Koyakutty, 2013. Multifunctional calcium phosphate nano-contrast agent for combined nuclear, magnetic and near-infrared in vivo imaging. Biomaterials, 34 (29), (if=8.387, ci=25) 9. GL Malarvizhi, AP Retnakumari, S Nair, Mansoor Koyakutty, 2014, Transferrin targeted core-shell nanomedicine for combinatorial delivery of doxorubicin and sorafenib against hepatocellular carcinoma (if=5.597, ci=18) 10. Chandran P, Kavalakatt A, .... Sidharthan N, Pavithran K, Nair S, Manzoor Koyakutty, 2014, Epigenetics targeted protein-vorinostat nanomedicine inducing apoptosis in heterogeneous population of primary AML cells .., Nanomedicine,10(4), 721 (if=5.597, ci=12) 381

KULKARNI, MAHESH JAGDISHRAO (b 1971), CSIR-National Chemical Laboratory, Pune

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr. Mahesh Kulkarni has carried out some excellent work in the area of discovery of alternative diagnostic markers for prediction of diabetes and its complication. Dr. Kulkarni’s work has demonstrated that HbA1c (N-1-(deoxyfructosyl) valine (DFV) β-hemoglobin (β-Hb), the currently used diagnostic marker, is believed to provide glycemic status of preceeding 90-120 days, is an early and reversible glycation product eventually undergoes irreversible advanced glycation modifications to form N-1-(carboxymethyl) valine (CMV) and N-1-(carboxyethyl) valine (CEV) proteoforms of β-Hb. Both CMV-β-Hb and CEV-β-Hb peptides show better correlation with the clinical parameters of diabetes, such as glucose levels, HbA1c measurement, and microalbuminuria. Therefore quantification of CMV and CEV peptides could be useful in treatment and management of diabetes (Clinical Proteom, 2016). In addition to hemoglobin, glycated albumin has been suggested as an alternative diagnostic marker to HbA1c. Dr. Kulkarni’s group has developed diagnostic fragment ion library for mass spectrometry based targeted quantification of glycated peptides of albumin, and identified glycation sensitive lysine residues that could be useful to assess the degree of glycation in diabetes (Mol Cell Proteom,2015 ). He has also unequivocally demonstrated that albumin protects low abundant plasma proteins from adverse effects of glycation and lower levels of albumin are associated with increased glycation of plasma proteins and HbA1c (J Proteome Res, 2012). Thus lower levels of albumin in diabetes could be potential risk factor for glycation induced complications. Proposer: Prof. Sourav Pal, Seconder: Prof. M. Udayakumar Ten Best Publications: 1. 37. Bhonsle HS, Korwar AM, Kote SS, Golegaonkar SB, Chougale AD, Shaik ML, Dhande NL, Giri AP, Shelgikar KM, Boppana R, Kulkarni MJ*. Low plasma albumin levels are associated with increased plasma protein glycation and HbA1c in diabetes. J Proteome R (if=4.17, ci=35) 2. Bansode SB, Chougale AD, Joshi RS, Giri AP, Bodhankar SL, Harsulkar AM, Kulkarni MJ*. Proteomic analysis of protease resistant proteins in the diabetic rat kidney. Mol Cell Proteomics. 2013 Jan;12(1):228-36 (if=5.91, ci=16) 3. Kesavan SK, Bhat S, Golegaonkar SB, Jagadeeshaprasad MG, Deshmukh AB, Patil HS, Bhosale SD, Shaikh ML, Thulasiram HV, Boppana R, Kulkarni MJ*. Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by med (if=5.22, ci=14) 4. Kulkarni MJ*, Korwar AM, Mary S, Bhonsle HS, Giri AP. Glycated proteome: from reaction to intervention. Proteomics Clin Appl. 2013 Jan;7(1-2):155-70. (if=2.95, ci=16) 5. Bansode SB, Jana A, Batkulwar KB, Warkad S, Joshi RS, Sengupta N*, Kulkarni MJ*. Molecular Investigations of Protriptyline as a Multi-Target Directed Ligand in Alzheimer's Disease. PLoS One. 2014 Aug 20;9(8):e105196. doi: 10.1371/journal.pone.010 (if=3.05, ci=7) 6. Batkulwar KB, Bansode SB, Patil GV, Godbole RK, Kazi RS, Chinnatambi S, Shanmugam D, Kulkarni MJ*. "Investigation of Phosphoproteome in RAGE signaling. Proteomics. 2015 Jan;15(2-3):245-59 (if=4.07, ci=4) 7. Korwar AM, Vannuruswamy G, Jagadeeshaprasad MG, Ramesha JH. Bhat S, Regin BS, Ramaswamy S, Giri AP, Mohan V, Balasumbramanyam M and Kulkarni MJ*. Development of diagnostic fragment ion library for glycated peptides of Human serum albumin: Targete (if=5.91, ci=10) 8. Golegaonkar SB, Tabreza SS, Pandita A, Shalini SA, Jagadeesha Prasad MG, Bansode SB, Gopalan SC, Kulkarni MJ*, and Mukhopadhyay A*. Rifampicin reduces Advanced Glycation End products and activates DAF-16 to increase life span in Caenorhabditis (if=5.76, ci=7) 9. Jagadeeshaprasad MG, Batkulwar KB, Meshram NN, Tiwari S, Korwar AM, Unnikrishnan AG, Kulkarni MJ*. Targeted quantification of N-1-(carboxymethyl) valine and N-1-(carboxyethyl) valine peptides of β- hemoglobin for better diagnostics in diabetes. C (if=3.47, ci=1) 10. Bhat S, Jagadeeshaprasad MG, Patil YR, Shaikh ML, Regin BS, Mohan V, Giri AP, Balasubramanyam M, Boppana R, Kulkarni MJ*. Proteomic insight reveals elevated levels of albumin in circulating immune complexes in diabetic plasma. Mol Cell Proteomics. (if=5.91, ci=2)

382

KUMAR, RAJEEV (b 1972), Professor of Urology, All India Institute of Medical Sciences, New Delhi

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

The nominee’s primary contribution has been a combination of clinical and basic research in the evaluation and management of male infertility. Infertile men are often subjected to investigations and treatments, including surgery, with little scientific justification. The nominee has questioned the role of such investigations, such as screening for tuberculosis, in infertile men (1-5). He has evaluated the role of empirical drug therapies (6-11) and suggested simplified algorithms and investigative protocols to minimize procedures (12-17). He has developed two new microsurgical techniques to simplify complex procedures (18-23). With a collaborative team for basic research, including an earlier ICMR task force project, they have evaluated genetic abnormalities including Y chromosome microdeletions, mitochondrial DNA mutations, and the role of oxidative stress in male infertility (24-54). They have identified novel mutations in the genome of infertile men and developed a multiplex PCR technique to minimize diagnostic evaluation. His second area of research is multiparametric magnetic resonance techniques in early prostate cancer diagnosis. Data gathered from in-vitro and in-vivo imaging MR studies (55-57) was used to determine cut-off values between normal, benign and malignant tissues (58). These values were validated on a cohort of men with suspected prostate cancer who underwent MR studies followed by prostate biopsy (59-60). Additional MR techniques were evaluated for targeting such biopsies (61-64) followed by the establishment of pre-biopsy MR protocols for detecting prostate cancer with high specificity which could increase diagnostic yield while avoiding unnecessary biopsies (65-68). (References as per Annexure 2-updated 2017) Proposer: Prof. Rakesh Kapoor, Seconder: Prof. Veereshwar Bhatnagar Ten Best Publications: 1. Javali TD, Dwivedi DK, Kumar R, Jagannathan NR, Thulkar S, Dinda AK (2014) Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL an (if=2.409, ci=7) 2. Kumar V, Jagannathan NR, Thulkar S, Kumar R (2012) Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer. Int J Urol. 2012; 19:602-13 (if=2.409, ci=18) 3. Kumar R, Anand A, Saxena V, Seth A, Dogra PN, Gupta NP (2008) Safety and efficacy of PCNL for management of staghorn calculi in pediatric patients. J Pediatr Urol. 2011;7(3):248-51 (if=0.898, ci=21) 4. Kumar R, Mukherjee S, Gupta NP (2010) Intussusception Vasoepididymostomy with Longitudinal Suture Placement for Idiopathic Obstructive Azoospermia. J Urol. 2010 ;183:1489-92 (if=4.471, ci=21) 5. Kumar R, Nayyar R, Kumar V, Gupta NP, Hemal AK, Jagannathan NR, Dattagupta S, Thulkar S (2008) Potential of Magnetic Resonance Spectroscopic Imaging in Predicting Absence of Prostate Cancer in Men with Serum Prostate-Specific Antigen Between 4 and 10 (if=2.188, ci=34) 6. Kumar R, Gautam G, Gupta NP (2006) Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol. 2006;176:1307-1312 (if=4.471, ci=35) 7. Kumar V, Jagannathan NR, Kumar R, Das SC, Jindal L, Thulkar S et al. (2006) Correlation between metabolite ratios and ADC values of prostate in men with increased PSA level. Magn Reson Imaging. 2006;24:541-8 (if=2.090, ci=47) 8. Kumar R, Kumar M, Jagannathan NR, Hemal AK, Gupta NP (2004) Proton Magnetic Resonance spectroscopy using a body coil in the diagnosis of carcinoma prostate. Urol Research. 2004;32:36-40 (if=1.000, ci=23) 9. Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility—a preliminary report. Int Urol Nephrol. 2002;34:369-72 (if=1.519, ci=73) 10. Hemal AK, Gupta NP, Kumar R. Comparison of retroperitoneoscopic nephrectomy with open surgery for tuberculous nonfunctioning kidneys. J Urol. 2000;164:32-5 (if=4.471, ci=39)

383

NAMPERUMALSAMY, VENKATESH PRAJNA (b 1966), Chief - Department of Cornea and Refractive surgery, Aravind Eye Hospital, Madurai

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr. N.Venkatesh Prajna combines busy clinical practice and laboratory research effectively. He conducted a randomized control study called as the Madurai Intraocular Lens Study involving 3400 patients that established the superiority of the technique of intraocular lens implantation (IOL) compared to simple intracapsular cataract extraction. This study published in American Journal of Ophthalmology, as a three part series, paved the way for large scale IOL implantations in developing countries. His contributions to the study of mycotic and bacterial keratitis is extensive. He was the Prinicpal Investigator in Mycotic Ulcer treatment trial (MUTT), which established the fact that different fungi respond to different antifungals and the results of this study altered the preferred practice pattern in the treatment of fungal keratitis even in developed countries. His basic research interest is in the areas of tear and corneal proteomics, immunology of corneal infections and in vivo confocal microscopy of limbal stem cells. His involvement and critical input led to framing new probing questions to explore additional problems. He complements the basic researchers and expands their approach to complex clinical problems. He has publications in several international journals such as American Journal of Ophthalmology, British Journal of Ophthalmology, JAMA and Nature Genetics. He is also a peer reviewer of several prestigious journals such as American Journal of Ophthalmology. Apart from all these he is an excellent teacher and mentor of young clinicians and researchers alike. Proposer: Prof. K.Dharmalingam, Seconder: Prof. G.Marimuthu Ten Best Publications: 1. Prajna NV, Chandrakanth KS, Kim R, Narendran V, Selvakumar S, Rohini G, Manoharan N, et al. (1998) The Madurai Intraocular Lens Study II: clinical outcomes. Am J Ophthalmol. ;125:14-25 (if=3.833, ci=106) 2. Prajna NV, Ellwein LB, Selvaraj S, Manjula K, Kupfer C. ( 2000) The Madurai Intraocular Lens Study IV: posterior capsule opacification. Am J Ophthalmol;130:304-309 (if=3.833, ci=44) 3. Prajna NV, Venkataswamy G. (2001).Cataract Blindness - the Indian Experience. Bull World Health Organ.;79:259-260 (if=5.302, ci=7) 4. Prajna NV, John RK, Nirmalan PK, Lalitha P, Srinivasan M. A (2003).Randomised Clinical Trial Comparing 2 Percentage Econazole and 5 Percentage Natamycin for the Treatment of Fungal Keratitis. Br J Ophthalmol.;87:1235-1237 (if=2.917, ci=41) 5. Prajna NV, Nirmalan PK, Mahalakshmi R, Lalitha P, Srinivasan M. (2004).Concurrent Use of 5 Percentage Natamycin and 2 Percentage Econazole for the Management of Fungal Keratitis. Cornea.;23:793-796. (if=2.106, ci=21) 6. Lalitha P, Prajna NV, Kabra A, Mahadevan K, Srinivasan M. (2006) Risk factors for treatment outcome in fungal keratitis. Ophthalmology. Apr;113(4):526-30. (if=4.825, ci=74) 7. Prajna VN, Nirmalan PK, Saravanan S, Srinivasan M. (2007). Economic Analysis of Corneal Ulcers in South India.Cornea.;26:119-122. (if=2.106 , ci=9) 8. Prajna NV, Krishnan T, Mascarenhas J, Rajaraman R, Prajna L, Srinivasan M,et al. (2013) The Mycotic Ulcer Treatment Trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol. ; 131:422-429. (if=2.106 , ci=20) 9. Prajna NV, Srinivasan M, Lalitha P, Krishnan T, Rajaraman R, Ravindran M, et al. (2013). Differences in Clinical Outcomes in Keratitis Due to Fungus and Bacteria. JAMA Ophthalmol. ; 131:1088- 1089. (if=2.106 , ci=8) 10. Uddaraju M, Mascarenhas J, Das MR, Radhakrishnan N, Keenan JD, Prajna L, Prajna VN. (2015).Corneal Cross-Linking as an Adjuvant Therapy in the Management of Recalcitrant Deep Stromal Fungal Keratitis: a randomized trial. Am J Ophthalmol.; 160:131-134. (if=3.871 , ci=2)

384

PAUL, JAISHREE (b 1952), Scientist 'C' (Professor); School of Life Sciences, Jawaharlal Nehru University, Delhi

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Her research is focused on two areas : (A). Interplay between the genetic and microbial factors in the pathogenesis of Inflammatory Bowel disease (Ulcerative colitis) in North Indian population. Association of SNPs in susceptible genes like Nucleotide Oligomerization Domain and Toll Like Receptors were evaluated in UC patients of Northern India for the first time. Functional analysis of these SNPs showed their impact on the altered immune response assessed by Real Time analysis of clinical samples. Regulation of miRNA in the pathogenesis of UC revealed site specific expression of miRNA during UC, modulating the expression of target genes. Enumeration of gut bacteria in UC patients targeting specific region of rDNA, revealed significant fluctuations in the concentration of predominant and subdominant species with concomitant change in concentration of their metabolites like SCFA. (B). Enteric Parasites Highthroughput molecular screening technique has been established for the detection and screening of enteric parasites like Entamoeba, Cryptosporidium and Giardia in clinical samples from different geographical locations. Clinical isolates exhibiting varying response to antiamoebic drugs are observed. Fluctuations in the gut flora in amoebic patients were enumerated. To correlate with the virulence of the parasite, characterization of clinical isolates been carried out using few loci of LINE and SINE repeat elements present abundantly in the genome of Entamoeba. Several loci with extensive polymorphism of SINE occupancy among different strains of E. histolytica proved the principle that the genomic distribution of SINEs is a valid method for typing of E. histolytica strains. Proposer: Prof. Kasturi Datta, Seconder: Prof. Sudha Bhattacharya Ten Best Publications: 1. Nath J, N Banyal, DS Gautam, SK Ghosh, B Singha, Jaishree Paul (2015) Systematic detection and association of Entamoeba species in stool samples from selected sites in India. Epidemiology and infection 143 (01), 108-119. (if=2.365, ci=4) 2. Kumari R, V Ahuja, Jaishree Paul (2013) Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India. World J Gastroenterol 19 (22), 3404-3414 (if=2.547, ci=19) 3. Ranjha R, Jaishree Paul ( 2013) Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer Inflammation Research 62 (4), 343-355 (if=2.15, ci=18) 4. Kumari V, Iyer LR, Roy R, Bhargava V, Panda S, Jaishree Paul, Verweij JJ, Clark CG, Bhattacharya A, Bhattacharya S (2013) Genomic distribution of SINEs in Entamoeba histolytica strains: implication for genotyping. BMC genomics 14:432 (if=4.39, ci=4) 5. Verma AK, R Verma, V Ahuja, Jaishree Paul (2012) Real-time analysis of gut flora in Entamoeba histolytica infected patients of Northern India. BMC Microbiology 12 (1), 183 (if=2.73, ci=14) 6. Verma R, V Ahuja, Jaishree Paul (2009) Frequency of single nucleotide polymorphisms in NOD1 gene of ulcerative colitis patients: a case-control study in the Indian population. BMC Medical genetics 10:82 (if=2.536, ci=10) 7. Verma R, Verma A.K., Ahuja V and Jaishree Paul (2010) Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India. Journal of Clinical Microbiol. 48: 4279–4282 (if=4.23, ci=45) 8. Rani R, RS Murthy, S Bhattacharya, V Ahuja, MA Rizvi, Jaishree Paul (2006) Changes in bacterial profile during amebiasis: demonstration of anaerobic bacteria in ALA pus samples. The American journal of Tropical Medicine and Hygiene 75 (5), 880-885(if=2.699, ci=11) 9. Srivastava S, S Bhattacharya, Jaishree Paul (2005) Species-and strain-specific probes derived from repetitive DNA for distinguishing Entamoeba histolytica and Entamoeba dispar. Experimental Parasitology 110 (3), 303-308 (if=1.64, ci=27) 10. Azam A, Jaishree Paul, D Sehgal, J Prasad, S Bhattacharya, A Bhattacharya (1996) Identification of novel genes from Entamoeba histolytica by expressed sequence tag analysis. Gene 181 (1), 113- 116 (if=2.07, ci=33)

385

SADAKSHARAM, JAYACHANDRAN (b 1964), Professor and HOD, Department of Oral Medicine and Radiology, Tamilnadu Govt. Dental College and Hospital, Chennai 600003

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr. Jayachandran has contributed significantly in the field of Oral medicine and radiology such as the application of Tissue Autofluorescence, diffuse reflectance and Raman spectroscopy in oral mucosal lesions. He has evaluated Colour Doppler USG in the diagnosis of metastatic lymph nodes in the patients of oral cancer. He is also interested in fields of early diagnosis of oral precancerous and cancerous lesions and has analysed Salivary interleukin-6 level , Chemilumiscence and Serum antioxidants levels in early diagnosis of Oral pre-cancer and Cancer and has employed Photodynamic therapy and Low intensity Laser therapy for treating oral pre-cancer. He is having particular interest in treatment of Oral Submucous Fibrosis and has evaluated Injection therapy and evaluation of prognosis for Oral Submucous fibrosis. He has analysed Cone beam Computed tomography in the field of dentistry to evaluate maxillofacial pathologies. He has performed epidemiological surveys on dental anomalies as well as Oral cancer in tertiary care hospitals. He has also carried out identification of oral lesions in HIV in ART vs. pre-ART patients and formulated dental considerations for HIV patients. He is a reviewer of many Journals including Proceedings of National academy of science India, Biological Science. He is actively working on Radiological method of dental age estimation for forensic purposes. He has presented best poster award in 104th Indian Science congress. He has delivered Doordarshan Programmes on Oral health and done epidemiological study , risk factor analysis and designed awareness program for in HIV patients. Proposer: Dr. Mohan V, Seconder: DR. M. Michael Aruldhas Ten Best Publications: 1. Jayachandran S, Meenakshi R. (2004)Cemento ossifying fibroma. Indian J Dent Res. Jan- Mar;15(1):35-9 (if=20, ci=11) 2. 2.Jayachandran, S., & Krithika, C. (2006). Mucormycosis presenting as palatal perforation .References.Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research, 17(3), 139–42 (if=20, ci=29) 3. Vedeswari CP, Jayachandran S, GanesanS.In vivo autofluorescence characteristics of pre- and post- treated oral submucous fi brosis: A pilot study. Indian J Dent Res 2009;20:261-7. (if=0.81, ci=9) 4. Suhanya, J., Aggarwal, C., Mohideen, K., Jayachandran, S., &Ponniah, I. (2010). Cherubism combined with epilepsy, mental retardation and gingival fibromatosis (Ramon syndrome): a case report. Head and Neck Pathology, 4(2), 126–31 (if=2.182, ci=16) 5. Sivabalan, S., Vedeswari, C. P., Jayachandran, S., Koteeswaran, D., Pravda, C., Aruna, P. R., &Ganesan, S. (2010). In vivo native fluorescence spectroscopy and nicotinamideadinine dinucleotide/flavin adenine dinucleotide reduction and oxidation state (if=3.188, ci=15) 6. Jayachandran S, Sachdeva SK(2012). Diagnostic accuracy of color Doppler ultrasonography in evaluation of cervical lymphnode in oral cancer patients. Indian J Dent Res;23:557-8 (if=20, ci=1) 7. Jayachandran, S., & Balaji, N. (2012). Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis.Indian Journal of Palliative Care, 18(3), 190–195 (if=0.708, ci=15) 8. Sadaksharam J., Nayaki, K. P. T. and PanneerSelvam, N. (2012), Treatment of oral lichen planus with methylene blue mediated photodynamic therapy – a clinical study. Photodermatology, Photoimmunology&Photomedicine, 28: 97–101 (if=1.516, ci=17) 9. PanneerSelvam, N. and Sadaksharam, J. (2015), Salivary interleukin-6 in the detection of oral cancer and precancer. Asia-Pacific Journal of Clinical Oncology, 11: 236–241. (if=1.542, ci=1) 10. Jayachandran S, Meenapriya PK, Ganesan S(2016). Raman spectroscopic analysis of blood, Urine, saliva and Tissue of oral potentially Malignant Disorders and Malignancy-a Diagnostic study. Int J Oral Craniofac Sci 2(1):011-014. (if=10, ci=1)

386

SOUNDARAPANDIAN, KANNAN (b 1972), Professor of Zoology, Periyar University, Salem-636 011 Member of the NASI: Yes (YON 2016, Animal Sciences)

The contributions of Prof. S.Kannan in development of enhanced smart delivery of gene / drugs of interest to target cancers are appreciable. His study has firstly demonstrated the presence of a target for the development of therapeutic agents for lung and breast cancers, namely cytosolic phospholipase A2α (cPLA2α) and Cycloxiginase 2. Secondly, target validation of cPLA2α and COX2 have been performed with a view to the development of highly specific, tumour directed anticancer drug deliver such as enzyme inhibitors and enzyme-targeted prodrugs namely Pyrrolidine-2 and Doxorubicin loaded antibody dependent nanoparticles etc. He also formulated multifunctional magnetic polymers nanocombination which is gaining more importance in cancer nanotheranostics due to their safety and their potential in delivering targeted functions. Further, they prepared the chitosan– silver–phycoerythrin nanocomposites (CS–Ag–PE NCs) to target breast cancer. These cancer nanotheranostic materials are useful in real-time monitoring of drug delivery and therapeutic action against tumor cells as they co-deliver therapeutic and imaging functions. They also reported that the use of natural fluorescent protein (R-phycoerythrin (PE)) in the preparation of novel multifunctional CS–Ag–PE NCs and the theranostic potentials of the synthesized nanocomposites (NCs) are the major contribution of his laboratory which have been evaluated against triple negative breast cancer (MDA-MB-231) cells which showed a promising results. The nanotherapeutic approach introduced by Kannan’s lab supports to develop tumor targeted nanocore/ nanopolymers with a pH dependent induction of apoptosis. He laid a strong foundation in understanding Cancer Nano- Theranostics. Proposer: Prof. M Radhakrishna Pillai, Seconder:Prof. G. Marimuthu Ten Best Publications: 1. R. Vivek, R.Thangam, S.Rajeshkumar, C.Rejeeth, G.Senthilkumar, S.Sivasubramanian, S. Vincent, D.Gopi, S.Kannan. 2016. Multifunctional Magnetite Polymer Therapeutic Nanocomposites with “Off-On” Mechanism for Efficient and Selective HER2 Targeted Cancer Therapy. ACS Applied Materials & Interfaces. 8 (3): 2262-2279. (if=6.78) 2. K.Shanthi, K.Vimala, D.Gopi, S.Kannan. 2015. Fabrication of a pH responsive DOX conjugated PEGylated palladium nanoparticle mediated drug delivery system: an in vitro and in vivo evaluation.RSC Advances, 5 (56), 44998-45014. (if=3.84, ci=5) 3. Vivek, R., Thangam, R., NipunBabu, V., Rejeeth, C., Sivasubramanian, S., Gunasekaran, P., Muthuchelian, K. and Kannan, S., 2014. Multifunctional HER2-Antibody Conjugated Polymeric Nanocarrier-Based Drug Delivery System for Multi-Drug-Resistant Breast Cancer Therapy. 6 (9):6469- 6480 (if=6.78, ci=29) 4. S Sundarraj, R Thangam, MV Sujitha, K Vimala, S Kannan. Ligand-conjugated mesoporous silica nanorattles based on enzyme targeted prodrug delivery system for effective lung cancer therapy. Toxicology and applied pharmacology, 2014; 275 (3), 232-243(if=3.705, ci=8) 5. MV Sujitha, S Kannan. Green synthesis of gold nanoparticles using Citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) aqueous extract and its characterization. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013; 102, 15-23(if=2.353, ci=56) 6. Thangam, R, Suresh, V, Princy, W.A, Rajkumar, M, SenthilKumar, N, Gunasekaran, P, Rengasamy, R, Anbazhagan, C, Kaveri, K, Kannan, S.C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro anti-proliferative activity through induction of apoptosis and G0/G1 cell cycle arrest. Food Chemistry, 2013; 140: 262-272. (if=3.334, ci=24) 7. R Vivek, V Nipun Babu, R Thangam, KS Subramanian, S Kannan. pH-responsive drug delivery of chitosan nanoparticles as Tamoxifen carriers for effective anti-tumor activity in breast cancer cells. Colloids and Surfaces B: Biointerfaces, 2013; 111, 117-123.(if=4.152, ci=23) 8. Suresh, V, Anbazhagan, C, Thangam, R, Senthil Kumar, D, Senthil Kumar, N, Kannan, S, Rengasamy, R, Palani, P.Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis. Carbohydrate Polymers, 2012; 92:1377-1385. (if=4.074, ci=8) 9. R Vivek, R Thangam, K Muthuchelian, P Gunasekaran, K Kaveri, Kannan, S. Green biosynthesis of silver nanoparticles from Annona squamosa leaf extract and its in vitro cytotoxic effect on MCF-7 cells. Process Biochemistry, 2012; 47 (12), 2405-2410 (if=2.516, ci=65) 10. Sundarraj, S, Thangam, R, Sreevani, V, Kaveri, K, Gunasekaran, P, Kannan, S; Gamma Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J. Ethnopharmacology, 2012; 141: 800-809.(if=2.998, ci=26)

387

TANDON, SALIL (b 1965), Consultant Urologist, N.E. Railway Hospital, Lucknow Uttar Pradesh.{HVS} Hospital, Lucknow, Uttar Pradesh

Member of the NASI: No (YON 2016, Medical & Forensic Sciences)

Dr. Salil Tandon was confered with Gold Medals and Certificates of Honours as a Medical Student. His novel work on “Stricture Urethra” helped in better treatment and understanding of pathology of this very common Urological problem. He received his Urology training from England and got his FRCS (Ireland). The GMC of Great Britain has granted him full registration based on his academic excellence. He is Reviewer of American Journal -Urology Gold and his publications have been cited in International journals including Urological Clinics of North America. He is the first Urologist from U.P. to develop Reproductive Medicine (received Andrology training from UK and Cleveland Clinic USA) as a new sub speciality in the state.His current area of Research- a) Single layer figure of eight loop technique for vas- reversal,b)Effect of life style factors on Reproductive Health c)Bariatric Surgery and Male infertility.d)Incidence of Genetic causes (Karyotype and Y Chromosome Micro deletion) for Male Infertility in Indian Population. These original research work will help in developing affordable treatment options for this very common health issue.For all his contribution in the field of Andrology he was awarded a)Begum Hazrat Mahal award b)U.P.Govt. Council of Science & Technology.Vigyan Ratna Award,c)DUSCON Award. He have been writing articles for newspapers,magazines and giving talks over doordarshan to create awareness for the problem of infertility. He along with panel of experts has formulated guidelines on male infertility which will benefit GP’s and Gynecologist all over India. Proposer: Prof. Shally Awasthi, Seconder: Prof. P. Pushpangadan Ten Best Publications: 1. R Donat, S Tandon, KM Grigor, JW Fowler.,2000, Neoadjuvant Androgen Blockade (NAB) in T1 and T2 prostate carcinoma. Histology and PSA – failure. After Radical Prostatectomy , accepted in supplement to Prostate cancer and Prostate disease,5. 2. R Donat, S Tandon, KM Grigor, JW Fowler. 2001,Neoadjuvant Androgen Blockade (NAB) in T1 and T2 prostate carcinoma. Histology and PSA – failure. After Radical Prostatectomy – URO ONCOLOGY, Vol.1,139-145 (if=Impact Factor 2.77 ) 3. S Tandon, ES Sabanegh .2008,Chronic Pain After Vasectomy (PVPS): A Diagnostic And Treatment Dilemma . BJUI July II;102,no. 2,166-169 (if=Impact Factor 3.13, ci=Cited by 40 ) 4. G Gupta, JP Singh, S Tandon, S Singh, C Nayak, H Singh, Ch.Raveendar, KRJ.Nair, P Oberai. Oct- Dec 2010"Evidence based clinical study to assess the usefulness of homeopathic medicines in patients of benign prostatic hyperplasia “Indian Journal (ci=Cited by 1) 5. Tait C, Tandon S, Sweeney S, Byrne D, Nabi G: 2011 Radical treatment for bladder cancer in Tayside: Non-random comparison of surgery versus radiotherapy. Scott Med , 56:115 (if= Impact Factor 0.55) 6. S Tandon.Feb 2011,"A productive conversation (infertility)"The Week.Health,,34 7. Tait C, Tandon S, Goodman C, Towenell N, Baker L, Nabi G: Oct 2011,Long-term Oncological outcomes of laparoscopic radical nephrectomy for kidney cancer resection: Dundee cohort and meta- analysis of observational studies. Surgical endoscopy- E (if=Impact Factor 3.3 , ci=Cited by 19 ) 8. G Gupta, JP Singh, S Tandon, S Singh, C Nayak, H Singh, et al Summer 2012, "Evidence based clinical study of homeopathic medicines in patients of benign prostatic hyperplasia" American Journal of Homoeopathic Medicine, Vol.105 No.2,63-69 9. Gupta AK, Tandon S.: March 2014,Interim result on the usefulness of homoeopathic therapy in Urolithiasis – An Observational Study. Journal of Surgical Sciences,Vol.4 issue I;19-23 10. TandonS : Antisperm Antibody in Men-“A Clinical Puzzle” J.Int.Coll.Surg.Ind.Sec:JICSIS(2017) 1(1):6- 11

388

BHATTACHARYA, JAYANTA (b 1968), Principal Investigator, Translational Health Science & Technology Institute, Gurgaon

Member of the NASI: Yes (YON 2015, Medical & Forensic Sciences)

The nominee (Dr Jayanta Bhattacharya) is an exceptionally bright and hard‐working scientist who is firmly committed towards studying HIV‐1 diversity and its association to vaccine development. We consider him an international expert in HIV virology. He has an outstanding research record and he has greatly contributed to the HIV research field with a number of seminal scientific papers. The nominee has made several major contributions in the area of HIV‐1 clade C entry and vaccinology. The nominee primarily through research in India (earlier at the National AIDS Research Institute, Pune and currently at the THSTI, National Capital Region) has delineated fundamental mechanism of HIV‐1 entry that is aiding vaccine research. The discoveries led platform in design of envelope based HIV‐1 immunogen that is currently being pursued at the International AIDS Vaccine Initiative (IAVI) laboratory at the Translational Health Science & Technology Institute (THSTI), Faridabad, India. One of his HIV‐1 clade C based construct is currently being taken forward for advanced clinical development. Dr. Bhattacharya's recent work on discovery of broadly neutralizing antibodies to HIV‐1 from Indian population is of significance as such inventions will considerably add on to current therapy regimen and policy. His work focusing on the subtype‐associated genetic variations primarily in envelope and additionally in other viral genes illustrated how these changes might be associated with the virus neutralization and fitness. Thus, his work has not only been bridging an important gap in the field of subtype C but has implications for HIV vaccine. Proposer: Prof. , Seconder: Prof. Shinjini Bhatnagar Ten Best Publications: 1. Patil, S., Kumar, R., Deshpande, S., Samal, S., Shrivastava, T., Boliar, S., Bansal, M., Chaudhary, N.K., Srikrishnan, A.K., Murugavel, K.G., Solomon, S., Simek, M., Koff, W.C., Goyal, R., Chakrabarti, B.K., Bhattacharya, J.* (2016). Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C Infected Elite Neutralizer Mediate Autologous Virus Escape through Novel Mutations in V1 Loop. Journal of Virology 90 (7): 3446-3457. (if=4.609, ci=Just Published) 2. Ringe, R., Phogat, S. and Bhattacharya, J*. (2012). Subtle alteration of residues including N-linked glycans in V2 loop modulates HIV-1 neutralization by PG9 and PG16 monoclonal antibodies. Virology 426: 34–41 (if=3.36 (in 2012), ci=18) 3. Ringe, R., Thakar, M. and Bhattacharya, J.* (2010). Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade 1 C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection. Retrovirology 7:76(if=5.236 (in 2010), ci=15) 4. Ringe, R., and Bhattacharya, J.* (2012). Association of enhanced HIV-1 neutralization by a single residue substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity. PLoS One 7(5): e37157 (if=3.723 (in 2012), ci=9) 5. Gharu, L., Ringe, R., and Bhattacharya, J*. (2011). HIV-1 clade C envelopes obtained from late stage symptomatic Indian patients varied in their ability towards relative CD4 usages and sensitivity to CCR5 antagonist TAK-779. Virus Research 158: 216–224 (if=2.941 (in 2011), ci=13) 6. Ringe, R., Sharma, D., Zolla-Pazner, S., Phogat, S., Risbud, A., Thakar, M., Paranjape, R and Bhattacharya, J.* (2011) A single amino acid substitution in the C4 region in gp120 confers enhanced neutralization of HIV-1 by modulating CD4 binding sites and V3 loop, Virology 418: 123–132 (if=3.351 (in 2011), ci=11) 7. Sharma, D. and Bhattacharya, J.* (2010) Evolutionary constraints acting on DDX3X protein potentially interferes with Rev-mediated nuclear export of HIV-1 RNA. PLoS One 5(3): e9613. (if=4.411 (in 2010), ci=6) 8. Bhattacharya, J., Repik, A. and Clapham, P.R. (2006). Gag regulates Human Immunodeficiency virus type 1 envelope association with detergent resistant membranes. Journal of Virology 80: 5292- 5300 (if=5.341 (in 2006), ci=87) 9. Bhattacharya, J., Peters, P.J., and Clapham, P.R. (2004). Human Immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: Impact on association with membrane lipid rafts and incorporation onto budding virus particles. Journal of Virology, 8: 5500-5506. (if=5.398 (in 2004), ci=84) 10. Bhattacharya, J.,* Peters, P.J.,* Hibbitts, S.,* Dittmar, M.T., Simmons, G.S, Bell, J., Simmonds, P.S. and Clapham, P.R. (2004). Biological analysis of HIV-R5 envelopes amplified from brain and lymph node tissue of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in brain that confer an enhanced tropism and fusigenicity for macrophages. Journal of Virology 78: 6915-6926 [* equal contribution]. (if=5.398 (in 2004), ci=156)

389

BHATTACHARYYA, MAITREE (b 1960), Professor, Department of Biochemistry, Calcutta University and Director, Jagadis Bose National Science Talent Search, Kolkata

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Prof. Maitree Bhattacharyya graduated from Presidency College with Honours in Physics and obtained M.Sc from Calcutta University. Started research career in Department of Biophysics and Molecular Biology, CU with PhD in 1991.Now she is Professor, Department of Biochemistry in University of Calcutta. Ten students have already been awarded PhD degree under her supervision and she is leading a group of ten research scholars which comprises of PhD and post doctoral students. Her major research interest is in the field of biomedical research. She worked on the oxidative and nitrosative stresses in thalassemia, arsenic toxicity, diabetes mellitus and in protein drug biomolecular interaction. Her major contribution lies in identifying the risk factors and biomarkers in the disease dynamics of diabetes and associated cardiovascular disease and dyslipidemia. She has also developed a kit for detection of Platelet shed Microparticles (MP) under Flow Cytometry Platform, for which the patent has been filed. This work has got immense significance as a diagnostic tool for prediction of cardiovascular disease in diabetes. She is also working to explore the microbial diversity in the coastal and estuarine area of Sunderban, Chilika and Gujarat. Apart from academic research and teaching she is passionate to develop scientific and technological sphere of India especially the human resource to the level of highest possible International Standard. To fulfill this ambition she has recently joined (on lien) as Director of Jagadis Bose National Science Talent Search, where young talents are nurtured and motivated to achieve the best quality human resource. Proposer : Prof. Gobardhan Das, Seconder : Prof. Ten Best Publications: 1. Dibyendu Chakraborty & Maitree Bhattacharyya (2001), Antioxidant defence status of Red Blood cell in B-thalassemia patient, Clinica Cheimica Acta (Elsevier), 305,123-129 (if=2.748, ci=81) 2. Maitree Bhattacharyya, U. Chaudhuri and R. K. Poddar (1990), Evidence for cooperative binding of chlorpromazine with haemoglobin : Equilibrium dialysis, fluorescence, quenching and oxygen release study, Biochemical Biophysical Research Communications, (Academic Press), 167, 1146-1153. (if=2.474, ci=70) 3. Chakraborty A ,Chowdhury S,Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes research and clinical practice. (Available online 13 December 2010.) Impact factor-2.1(if=2.853, ci=60) 4. J. Bhattacharyya, Maitree Bhattacharyya, A. S. Chakraborty, U. Chaudhuri and R. K. Poddar (1994), Binding of chlorpromazine with hemoglobin and myoglobin: A comparative study -Biochemical Pharmacology (pergamon Press), 11, 2049-2053. (if=4.772, ci=55) 5. Adak S, Chowdhury S and Bhattacharyya M. Dynamic and electrokinetic behavior of erythrocyte membrane in diabetes mellitus and diabetic cardiovascular disease Biochimica et Biophysica Acta (BBA) - General Subjects. (2008) Biochimica et Biophysica Acta ,1780, 108-115 (if=4.554, ci=26) 6. Arindam Saha, Sangeeta Adak, Subhankar Chowdhury, Maitree Bhattacharyya (2005), Enhanced Oxygen releasing capacity and Oxidative stress in Diabetes Mellitus and Diabetes Mellitus Associated Cardiovascular Disease: A comparative study, Clinica Chimica Acta,( Elsevier) 361,141-149 (if=2.748, ci=26) 7. J. Bhattacharyya, M. Bhattacharyya, A. S. Chakrabarty, U. Chaudhuri & R.K. Poddar (1998), Structural organisation of hemoglobin and myoglobin influence their binding behaviour with phenothiazines, International Journal of Biological Macromolecules (Elsevier), 23, 11-18. (if=3.227, ci=23) 8. Dibyendu Chakraborty & Maitree Bhattacharyya (2000), Deferiprone (LI) induced conformation change of Hemoglobin: A fluorescence and CD spectroscopic study, Molecular and Cellular Biochemistry, 204. 17-20. (if=2.388, ci=18) 9. Maitree Bhattacharyya, U. Chaudhuri and R.K.Poddar (1990), Studies on the interaction of chlorpromazine with haemoglobin, International Journal of Biological Macromolecules, (Butterworths) 12, 297-301 (if=3.227, ci=12) 10. Adak S, Sengupta S , Chowdhury S and Bhattacharyya M.Co-existence of risk and protective haplotypes of Calpain 10 gene to type 2 diabetes in the eastern Indian population. Diabetes and Vascular Disease Research. 2010; 7; 63 (if=3.04, ci=11) 390

CHAKRABARTI, SUBHABRATA (b 1972), Associate Director, L.V. Prasad Eye Institute, Hyderabad

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Subhabrata Chakrabarti's work on the genomics of complex eye diseases, done entirely in India, have been widely recognized as pioneering in the field and has lead to the understanding of their molecular mechanisms. This has also paved the way for devising molecular diagnostics for predictive testing. His research works has been recognized in the form of several honours and awards; notable being the 'Research Recognition Award' of the World Glaucoma Association, several academic responsibilities at the Associations for Research in Vision and Ophthalmology (ARVO) and Young Scientist/Associate of all the 3 Science Academies of India (INSA, NASI and IASc) and TWAS. Proposer: Prof. Partha P. Majumder, Seconder: Prof. D. Balasubramanian Ten Best Publications: 1. Reddy ABM, Kaur K, Mandal AK, Panicker SG, Thomas R, Hasnain SE, Balasubramanian D, Chakrabarti S* (2004) Mutation spectrum of CYP1B1 gene in Indian primary congenital glaucoma patients. Mol Vis, 10: 696-702. (if=1.986, ci=52) 2. Kaur K, Reddy ABM, Mukhopadhyay A, Mandal AK, Hasnain SE, Ray K, Thomas R, Balasubramanian D, Chakrabarti S* (2005) Myocilin gene implicated in primary congenital glaucoma. Clin Genet, 67: 335- 340. (if=3.931, ci=60) 3. Chakrabarti S*, Kaur K, Kaur I, Mandal AK, Parikh R, Thomas R, Majumder PP (2006) Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds. Invest Ophthalmol Vis Sci, 47: 43-47. (if=3.404, ci=43) 4. Kaur I, Hussain A, Hussain N, Das TP, Pathangay A, Mathai A, Hussain A, Nutheti R, Nirmalan PK, Chakrabarti S* (2006) Analysis of CFH, TLR4 and APOE polymorphisms in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration. Invest Ophthalmol Vis Sci, 47: 3729-3735. (if=3.404, ci=71) 5. Kaur I, Katta S, Hussain A, Hussain N, Mathai A, Narayanan R, Hussain A, Reddy R, Majji AB, Das TP, Chakrabarti S* (2008) Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci, 49: 1771-1776. (if=3.404, ci=63) 6. Chakrabarti S*, Ghanekar Y, Kaur K, Kaur I, Mandal A, Rao KN, Parikh RS, Thomas R, Majumder PP (2010) A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma. Hum Mol Genet, 19: 4083-4090. (if=6.393, ci=20) 7. Thakkinstian A, McEvoy M, Chakravarthy U, Chakrabarti S, McKay GJ, Ryu E, Silvestri G, Kaur I, Francis P, Iwata T, Akahori M, Arning A, Edwards A, Seddon J, Attia J (2012) The Association Between Complement Component 2/Complement Factor B Polymorphisms and Age-Related Macular Degeneration: A HuGE Review and Meta-Analysis. Am J Epidemiol, 176: 361-372. (if=5.230, ci=35) 8. Rao KN, Kaur I, Chakrabarti S* (2009) Lack of association of three POAG susceptible loci with primary glaucomas in an Indian population. Proc Natl Acad Sci, USA, 106: E125-126. (if=9.674, ci=18) 9. Kaur I, Rathi S, Chakrabarti S* (2010) Variations in TIMP3 are associated with age-related macular degeneration. Proc Natl Acad Sci, USA, 107: E112-113. (if=9.674, ci=15) 10. de Melo MB, Mandal AK, Tavares IM, Ali MH, Kabra M, de Vasconcellos JP, Senthil S, Sallum JM, Kaur I, Betinjane AJ, Moura CR, Paula JS, Costa KA, Sarfarazi M, Paolera MD, Finzi S, Ferraz VE, Costa VP, Belfort R Jr., Chakrabarti S*. Genotype-phenotype correlations in CYP1B1-associated primary congenital glaucoma patients representing two large cohorts from India and Brazil. PLoS One 2015; 10: e0127147. (if=3.234, ci=5)

391

CHANDAK, GIRIRAJ RATAN (b 1963), Senior Principal Scientist, Centre for Cellular and Molecular Biology, Hyderabad

Member of the NASI : No (YON 2015, Medical & Forensic Sciences)

The outstanding contribution of Dr G R Chandak demonstrating the genetic and mutational heterogeneity and gene-nutrient interaction in prevalent complex diseases, such as chronic pancreatitis, diabetes mellitus, neural tube defects, etc. in Indians can be seen from his regular contribution in journals of Nature group including Nature and Nature Genetics. He has identified two novel genes, SPINK1 and CTSB that predict susceptibility to chronic pancreatitis in Indians, which established genetic basis of tropical calcific pancreatitis and inclusion in the Online Mendelian Inheritance in Man (MIM#608819) and are being used for genetic testing of chronic pancreatitis. Dr Chandak has been the first to show that genetic susceptibility of type 2 diabetes in Indians is different than Europeans, especially for traits like central obesity and insulin resistance. He has established the causal role of maternal B12 deficiency and one-carbon metabolism in predicting low birth weight and adiposity in their children. Using animal models of B12 deficiency, he has demonstrated altered PPAR signalling pathway in explaining fetal programming of obesity, insulin resistance and altered lipid metabolism. His studies provide a possible link of differential epigenetic regulation of candidate type 2 diabetes genes with B12 deficiency that is widely prevalent in the Indians. In contrast to the globally established role of folate deficiency, his studies have conclusively established major role for maternal B12 deficiency in the risk of neural tube defects. He has also led the way in creating awareness about preventing monogenic genetic disorders by prenatal diagnosis and genetic counselling using cost-effective protocols. Proposer : Dr Ch Mohan Rao, Seconder : Dr. R Sankaranarayanan Ten Best Publications : 1. Georg B. Ehret, Patricia B. Munroe, Kenneth M. Rice, Murielle Bochud, ICBP-GWAS Consortium, G R Chandak et al. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular risk. Nature, 478(7367) : 103-9. (if=36.280, ci=624) 2. P D Gluckman, P Bateson, A S Beedle, Z A Bhutta, M A Hanson, C Law, K V Anokhin, P Bougnères, G R Chandak, P Dasupta, G D Smith, P T Ellison, T Forrester, S F Gilbert, E Jablonka, H Kaplan, A M Prentice, S J Simpson, R Uauy & M J West-Eberhard (2009). “Development and human disease – a synthesis of evolutionary, medical, anthropological, and economic perspectives”. Lancet 373(9675) : 1654-1657. (if=30.758, ci=203) 3. Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, G R Chandak, et al. Loss-of-function mutations in CPA1 are strongly associated with early-onset chronic pancreatitis. Nature Genetics. 2013 Oct;45(10) : 1216-20. doi : 10.1038/ng.2730. Epub 2013 Aug 18(if=29.648, ci=36) 4. G R Chandak, C S Janipalli, S Bhaskar, S R Kulkarni, P Mohankrishna, A T Hattersley, T M Frayling, C S Yajnik (2007). Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50(1) : 63-67.(if=6.227, ci=193) 5. G R Chandak, M Mohd Idris, D Nageshwar Reddy, S Bhaskar, PVJ Sriram and L Singh (2002). “Mutations in Pancreatic Secretory Trypsin Inhibitor (PSTI/SPINK1) rather than Cationic Trypsinogen Gene (PRSS1) are Significantly Associated with Tropical Calcific Pancreatitis”. J Medical Genetics; 39 : 347-351. (if=7,774, ci=151) 6. Ganesh Chauhan, Charles J Spurgeon, 12 more authors and G R Chandak (2010). Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC3018, HHEX, CDKN2A, IGF2BP2 AND CDKAL1 on the risk of type 2 diabetes in 5148 Indians. Diabetes ;59(8) : 2068-74.(if=8.889, ci=85) 7. C S Yajnik, C S Janipalli, S Bhaskar, S R Kulkarni, R M Freathy, S Prakash, K R Mani, M N Weedon,, S D Kale, J Deshpande, G V Krishnaveni, S R Veena, C H D Fall, M I McCarthy, T M Frayling, A T Hattersley, G R Chandak (2009). “FTO Gene Variants are Associated with Type 2 Diabetes but not with Obesity in South Asian Indians”. Diabetologia; 52 : 247-252. (if=6.227, ci=116) 8. Swapna Mahurkar, M Mohd Idris, D Nageshwar Reddy, S Bhaskar, G V Rao, V Thomas, Lalji Singh, G R Chandak (2006). Association of Cathepsin B Polymorphisms with Tropical Calcific Pancreatitis. Gut 55 : 1270-1275. (if=10.111, ci=60) 9. G R Chandak, M Mohd Idris, D Nageshwar Reddy, K Radha Mani, S Bhaskar, G V Rao and L Singh (2004). “Absence of PRSS1 Mutations and Association of SPINK1 Trypsin Inhibitor Mutations in Hereditary and Non-Hereditary Chronic Pancreatitis”. Gut; 53(5) : 722-27. (if=10.111, ci=72) 10. Krishnaveni, S Veena, C Osmond, CHD Fall. Maternal homocysteine in pregnancy and offspring birth weight : Epidemiological associations and Mendelian randomization analysis. Int J Epidemiology 22 July 2014. Epub ahead of print. PMID : 25052622. (if=6.982, ci=2) 392

CHATTOPADHYAY, DEBPRASAD (b 1959), Scientist G & Director, ICMR-National Institute of Traditional Medicine, Belagavi

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr. Chattopadhyay has exceedingly contributed in the field of Ethnomedicine, towards drug discovery against emerging, re-emerging and difficult to treat diseases. Finding new therapies from an untapped natural resource is the need of the hour. His group has validated herbs, herbal preparations/ formulas used in traditional practices of diverse Indian tribes including Onge, Nicobarese, Shompen, Birhore, Kattabhai, Santal etc, and identified molecules with pharmacological potentials such as anti-inflammatory, antibacterial, antiviral, contraceptive drugs. His group has also revealed the mechanism of action of these agents. The most notable one is the isolation and identification of an anti-HSV alkaloid. The mechanistic study showed that it inhibits the immediate early transcription of HSV in-vitro and in-vivo. The same approach helped to find new principles for typhoid and tuberculosis. His ground breaking work with an existing drug demonstrate alters the membrane permeability of drug-resistant bacteria, a hope to the management of microbial drug-resistant problem. In addition Dr Chattopadhyay significantly contributed in contraception research, another challenging area most relevant to India. Contraception without side effect is highly desirable. His group has identified a phenolic having potent sperm motility inhibiting activity from a preparation used by Onge. Altogether his ethnomedicinal approach is unique and highly successful in settling the principles of the management of HSV,typhoid, contraception and wound healing. India has vast resources of ethnomedicinal plants, and Dr Chattopadhyay has disseminated to common people. Therefore, the awareness to use herbal formulation from the age-old practices is led and fostered by him. Proposer: Dr , Seconder: Prof Subrata Majumder Ten Best Publications: 1. Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). Altered membrane permeability as the basis of bactericidal action of methdilazine. J Antimicrobial Chemotherapy 42: 83-85 (if=5.439, ci=43) 2. Chattopadhyay D, Maiti K, Kundu AP, Chakrabarty MS, Bhadra R, Mandal SC, Mandal AB (2001). Antimicrobial activity of Alstonia macrophylla: folklore of Bay Islands. Journal of Ethnopharmacology 77: 49-55 (if=3.055, ci=93) 3. Chattopadhyay D, Arunachalam G, Mandal AB, Sur Tapas K, Mandal SC, Bhattacharya SK (2002). Antimicrobial and anti-inflammatory activity of Mallotus peltatus leaf extract. Journal of Ethnopharmacology 82(2-3): 229-237 (if=3.055, ci=177) 4. Arunachalam G, Chattopadhyay D, Chatterjee S, Mandal AB, Sur TK, Mandal SC (2002). Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. Leaf extract. Phytomedicine 9(7): 632- 635 (if=3.268, ci=38) 5. Chattopadhyay D, Arunachalam G, Mandal AB, Bhadra R, Mandal SC (2003). CNS activity of Mallotus peltatus Muell Arg. Leaf extracts: An ethnomedicine of Bay Islands. Journal of Ethnopharmacology 85(1): 99-105 (if=3.055, ci=40) 6. Chattopadhyay D, Arunachalam G, Bhadra R, Ghosh L, Mandal AB (2004). CNS activity of the leaf extracts of Alstonia macrophylla Wall ex A. DC: An Ethnomedicine of Bay Islands. Fitoterapia 75(7-8): 673-682. (if=2.408, ci=66) 7. Chattopadhyay D, Arunachalam G, Mandal SC, Ghosh L, Rajendran K, Mandal AB, Bhattacharya SK (2005). Antipyretic activity of leaf extract of Alstonia macrophylla Wall ex A. DC: An ethnomedicine of Andaman Islands. J Pharmacy & Pharmaceutical Sciences (if=2.85, ci=82) 8. Chattopadhyay D, Dungdung SR, Majumder GC, Bhattacharya SK, Mandal AB (2005). A potent sperm motility inhibiting bioflavonoids from an Ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC. Leaf extract. Contraception 71(5):372-378 (if=3.09, ci=29) 9. Ghosh S, Samanta A, Mandal NB, Banerjee S, Chattopadhyay D (2012). Evaluation of wound healing activity of methanolic extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation. Journal of Ethnopha (if=3.055, ci=25) 10. Bag P, Ojha D, Mukherjee H, Halder UC, Mondal S, Nandi S, Sharon A, Chakrabarti S, Chattopadhyay D (2013). An indole alkaloid from a Tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infecte (if=3.534, ci=20)

393

COLAH, ROSHAN BEHRAM (b 1952) Former Scientist G & Director-in-Charge, National Institute of Immunohaematology, (ICMR), Mumbai.

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr Roshan Colah is a researcher of international standing and repute . Over last 35 or more years she has been a beacon of research on haemoglobinopathies and red cell enzymopathies in this country. In more than 250 of her research paper one can she her evolution from a student researcher to an erudite scientist. Most of these papers have been published in high impact international journals . she developed a new technique for prenatal diagnosis of haemoglobinopathies . Her technique of reverse covalent dot blot hybridization of common haemoglobinopathy mutation in India is a patented technique.She established a comprehensive prenatal diagnosis centre in NIIh where she worked. Herresearch on hydroxyurea in thalassaemia , Hydroxy urea as an iron chelator etc got critical national acclaim. Her work on molecular pathology and epistatic interaction of haemoglobinopathy in modulating its clinical presentation constitute a substantial bulk of her research work. At present very few laboratory in India investigates red cell enzymopathy comprehensively and the only one such comprehensive laboratory was established by her at NIIH , Mumbai. Dr Coalh is a member in many national and international committees . She has written several chapters in quite a few books and edited herself 3 books for every day use by haemoglobinopathy research. In fact to day in india nobody stands as tall as her in haemoglobinopathy research . She deserved this fellowship long time back I strongly endorse her fellowship in the academy without any further delay. Proposer : Prof. Kanjaksha Ghosh, Seconder : Dr Smita Mahale Ten Best Publications : 1. Sukumar Sridevi ,Colah, Roshan, Mohanty Dipika. (2002) G6PD gene mutations in India producing drug -inducing hemolytic anemia. Br. J.Haematol 116:671-672 IF=4.72; CI=24 2. D’Souza E, Sawant P, Nadkarni A, Gorakshakar A, Mohanty D, Ghosh K, Colah R. (2008) Evaluation of the use of monoclonal antibodies and nested PCR for non-invasive prenatal diagnosis of hemolobinopatheis in India. Am J Clin Pathol. 130(2):202-9. IF=2.89; CI=11 3. Colah R, Gorakshakar A, Nadkarni A, Phanasgaonkar S, Surve R, Sawant P, Mohanty D, Ghosh K. (2009) Regional heterogeneity of beta thalassemia mutations in the multi ethnic Indian population Blood Cells Mol Dis.; 42(3):241-6. IF=2.549; CI= 38 4. Khushnooma Y Italia, Farah Jijina, Rashid Merchant, Sangeeta Panjwani, Anita H Nadkarni, Pratibha M Sawant, Sona B Nair, Kanjaksha Ghosh Roshan B Colah (2009). Response to hydroxyurea in beta- thalassemia major and intermedia: Experience in western India. Clin Chim. Acta. 407; 10-15. IF=2.960; CI= 51 5. Italia K, Jain D, Gattani S, Jijina F, Nadkarni A, Sawant P, Nair S, Mohanty D, Ghosh K, Colah R. (2009) Hydroxyurea in sickle cell disease – a study of clinico – pharamacological efficacy in the Indian haplotype. Blood Cells Mol Dis. 42(1):25-31. IF= 2.549; CI= 51 6. Colah R, Gorakshakar A, Phanasgaonkar S, D'Souza E, Nadkarni A, Surve R, Sawant P, Master D, Patel R, Ghosh K, Mohanty D. (2010) Epidemiology of beta – thalassemia in West ern India:mapping the frequencies and mutations in sub – regions of Maharashtra and Gujarat. Br J Haematol. 149; 739 – 47. IF= 4.942; CI= 36 7. Colah R, Mukherjee M, Ghosh K.(2014) Sickle cell disease in India. Curr Opin Hematol.;21(3):215-23. IF=4.11; CI= 18 8. Warang PP, Kedar PS, Shanmukaiah C, Ghosh K, Colah RB. (2015) Clinical spectrum and molecular basis of recessive congenital methemoglobinemia in India.Clin Genet. 87(1):62-7. IF= 3.89; CI= 9 9. Italia K, Kangne H, Shanmukaiah C, Nadkarni AH, Ghosh K, Colah RB. (2015) Variable phenotypes of sickle cell disease in India with the Arab-Indian haplotype. Br J Haematol. 2015 ;168(1):156-9 IF= 5.4; CI= 7 10. Upadhye DS, Jain DL, Trivedi YL, Nadkarni AH, Ghosh K, Colah RB.(2016) Neonatal Screening and the Clinical Outcome in Children with Sickle Cell Disease in Central India. PLoS One. 11(1):e0147081. IF= 4.41; CI= 4

394

DAS, SATYA NARAYAN (b 1952), Professor, Department of Biotechnology, AIIMS, New Delhi

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr. Das has made significant contribution in cancer research specially in understanding the genetic susceptibility to breast (Valarmathi et al, 2003, 2004) and oral cancer (Jha et al, 2013; Karimi et al, 2013; Bharti et al, 2013; Gaur et al, 2011a, 2011b; Mittal et al, 2010; Gupta et al, 2008). In case with familial breast cancer his group detected about 20 novel mutations in BRCA1 and BRCA 2 gene while in oral cancer novel polymorphisms were reported in hMLH1 gene, TNF-alpha and TNF receptor genes, COX-2, TGF-beta, IL-4 and IL-6 genes and CTLA-4 genes that may be useful to screen population at a higher risk. Dr. Das was first to report abnormal expression of PI3K isoforms (Garg et al, 2013) and COX-2 (Kapoor et al, 2010) in oral cancer patients and showed that peptide inhibitors of COX-2 significantly inhibited tumour cell growth and proliferation. These findings may lead to development of peptide/biological inhibitors of PI3K and COX-2 for chemopreventive and chemotherapeutic strategy for oral cancer. Recently his group showed impaired population and functions of invariant Natural Killer T (iNKT) cell subsets in oral cancer patients (Singh et al, 2013, 2015). They further showed that selective activation of iNKT cells by its ligand along with tumour antigen via dendritic cells significantly reduced tumour cell viability and enhanced apoptosis. These observations will provide an efficient process of NKT cell-based vaccination of oral cancer patients in order to prevent development and recurrence of the tumours. Proposer : Prof. Y. D. Sharma, Seconder : Prof. J. S. Tyagi Ten Best Publications: 1. Valarmathi MT, Agarwal A, Deo SVS, Shukla NK, Das SN (2003) BRCA1 germline mutations in Indian familial breast cancer. Hum Mutat. 21(1): 98-99. (On-line). (if=7.033) 2. Valarmathi MT, Sawhney M, Deo SVS, Shukla NK, Das SN (2004). Novel germline mutations in BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Hum Mutat. 23(2): 205. (on-line). (if=7.033) 3. Manchanda P, Sharma SC, Das SN. (2006) Differential regulation of IL-2 and IL-4 in patients with tobacco related oral squamous cell carcinoma. Oral Dis. 12: 455-462. (if=2.145) 4. Gupta R, Sharma SC and Das SN (2008): Association of TNF-α and TNFR1 promoters and 3’ UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco related Oral Carcinoma in Asian Indians. Oral Oncol. 44: 445-63. (if=3.123) 5. Kapoor V, Singh AK, Dey S, Sharma SC, Das SN (2010). Circulating COX-2 in patients with tobacco- related intraoral Squamous cell Carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. J. Cancer Res Clin Oncol 136: 1795-1804. (if=3.009) 6. Gaur P, Qadir GA, Upadhyay S, Singh AK, Shukla NK, Das SN (2012): Skewed immunological balance between Th17 (CD4+IL17A+) and Treg (CD4+ CD25+ FOXP3+) cells in human oral squamous cell carcinoma. Cellular Oncol (Dordr). 35(5):335-43. (if=3.105) 7. Jha R, Gaur P, Sharma SC and Das SN (2013) Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Gene :526:223-227. (if=2.341) 8. Garg R, Kapoor, V, Mittal M, Singh MK, Shukla NK and Das SN (2013). Abnormal expression of PI3K isoforms in patients with tobacco-related oral squamous cell carcinoma. Clin Chim Acta. 416 (1): 100- 106. (if=2.661) 9. Singh AK, Shukla NK, Das SN (2013). Altered Invariant Natural Killer T cell subsets and functions in patients with oral squamous cell carcinoma. Hum Immunol. 78: 468-477 (if=2.199) 10. Singh AK, Gaur P, Shukla NK, Das SN (2015). Differential dendritic cell-mediated activation and functions of invariant NKT cell subsets in oral cancer. Oral Dis. 21(1): e105-e113. (if=2.377)

395

HALDER, ASHUTOSH (b 1961), Professor & Head, Department of Reproductive Biology, AIIMS, New Delhi

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr. Halder is well known authority in Reproductive Genetics, Reproductive Endocrinology and Reproductive Biology. He has made significant contribution in Reproductive Sciences (infertility, reproductive wastage, malformations, disorder of sex development, prenatal/ preimplantation research, etc). He has developed Molecular Cytogenetic Specialty at AIIMS which is now reputed as Resource centre in Molecular Cytogenetics. He conducts national workshop annually to generate human resources in Molecular Cytogenetics. Dr. Halder is involved in teaching, training, research and patient care related work. He has published about 75 full length research papers (last 2 in Andrology & Frontier in Bioscience/Landmark edition, in press), edited three books/ monograph/ laboratory manual and several book chapters. Many of his publications are well cited; total citations over 760 (citations in google scholar 646 & research gate 575). He has also undertaken several significant research projects of national agencies. His research works are on PCOS, POF, familial primary amenorrhoea, hyperprolactinemia, primary testicular failure, biological basis of skewed sex ratio and malformation. He is expert member of various National Institutes/Government Organizations, reviewer and editorial board member for various national & international medical journals. He is guiding/ guided 7 PhD student as chief guide and over 25 as co-guide/doctoral committee member besides guiding 6 DM student. He is the recipient of ICMR international fellowship, commonwealth scholar, pathology honor, silver medal in 3 national conferences and FAMS. He is now heading Reproductive Biology and working for several new courses and facilities, including semen banking at AIIMS, New Delhi. Proposer: Prof. VK Paul, Seconder: Prof. R Goswami Ten Best Publications: 1. Haldar A, Sharma AK, Phadke SR, Jain A, Agarwal SS. 1994 OEIS Complex with Cranio-Facial anomalies: Defect of Blastogenesis? Am. J. Med. Genetics. 53: 21-23. (if=2.1, ci=41) 2. Tutschek B, Sherlock J, Halder A, Delhanty J, Rodeck C, Adinolfi M. 1995 Isolation of Fetal Cells from transcervical samples by Micromanipulation: Molecular confirmation of their fetal origin and diagnosis of fetal aneuploidies. Prenatal Diagnosis (if=3.04, ci=61; patent citation 3 as US Patent 6210889; EP Patent 1434887 & 1613743) 3. Adinolfi M, Sherlock J, Tutschek B, Halder A, Delhanty J, Rodeck C. 1995 Detection of Fetal Cells in Transcervical Sample & Prenatal Diagnosis of Chromosomal abnormalities. Prenatal Diagnosis. 15(10): 943-950. (if=3.04, ci=62; patent citation 2 as US Patent 6210889B1 &US20040197832 A1) 4. Sherlock J, Halder A, Tutschek B, Rodeck C, Adinolfi M. 1997 Prenatal detection of fetal aneuploidies using transcervical cell samples. J Med Genet. 34: 302-305. (if=5.65, ci=44; patent citation 1 as EP Patent 1434887) 5. Agarwal S, Kishore R, Haldar A. 1995 Outcome of pregnancy in women with Recurrent Spontaneous Abortion following Immunotherapy with Allogenic Lymphocytes. Human Reproduction. 10(9): 2280-2284 (if=4.71, ci=17) 6. Kishore R, Agarwal S, Haldar A, et al. 1996 HLA sharing, Antipaternal Cytotoxic Antibodies & MLR Blocking Factors in women with Recurrent Abortions. J. Obstet. Gynaecol. Res. 22(2): 177-183 (if=1.01, ci=38) 7. Halder A, Fauzdar A, Kumar A. 2005 Serum Inhibin B and Follicle Stimulating Hormone Levels as Markers in the Evaluation of Azoospermic Men: A Comparison. Andrologia 37: 173-179 (if=1.44, ci=38) 8. Halder A and Fauzdar A. 2006 Extreme Skewing of Sex Ratio and Low Aneuploidy in Recurrent Early Missed Abortion. Ind J Med Res 124: 41-50 (if=1.45, ci=16) 9. Yadav N, Sumod K, Kumar S, Jain M, Halder A, Saxena R, Mukhopadhyay A. 2009 Therapeutic effect of bone marrow-derived liver cells in phenotypic correction of murine hemophilia A. Blood 114: 4552-4561 (if=11.85, ci=28) 10. Halder A, Jain M, Chaudhary I, Kabra M. 2010 Prevalence of 22q11.2 microdeletion in 146 patients with cardiac malformation in a referral hospital of North India. BMC Medical Genetics 11: 101 (if=2.73, ci=22)

396

HUSAIN, NUZHAT (b 1961), Director, Dean Dr.RMLIMS, Officer In-charge State Referral Centre for Lab Investigations, Professor and Head of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow

Member of the NASI : No (YON 2015, Medical & Forensic Sciences)

It is my pleasure to recommend NASI Fellowship for Prof. Nuzhat Husain who has outstanding academic and scientific profile. With her persistent hard work and devotion she has many Scholarships, medals and laurels to her credit. She has established Pathology department at RMLIMS with high-end equipments, has been a popular educator and enlightening guide of 30 PhD and more than 70 MD students. She has an excellent scientific profile depicted by 156 publications in National and International Journals. She has international research training on Molecular Neuro-Oncology and Gene Therapy, at Massachusetts General Hospital, Harvard University, Boston , USA. Her major research area has been Neuro pathology and Neuro-Oncology which has now further broadened to oncology. She is presently working on regulatory gene mutations, stem cells expression and liquid biopsies in various cancers. As director of RMLIMS she has an experience of government entrepreneurships, her major focus is providing high end medical care and education at an affordable cost, with the public health care system. She has innovatively established State Referral Centre for Lab Investigations, Telepathology and Telemedicine facilities at RMLIMS. Under Professor N. Husain’s leadership major expansion programs at the institute including MCI recognition and post graduate programs have been implemented. In view of her comprehensive leadership in science, academia and administration I strongly recommend her fellowship at NASI. Proposer : Prof. Chitra Sarkar , Seconder : Prof R.K. Gupta Ten Best Publications : 1. Husain N, Kumar P. Pathology of CNS infections. Neuro-Imaging Clinics of North America, 2011, 21 : 757-75 (if=1.47, ci=2) 2. Husain N,Kumari M, Husain M. Tumor irrigation fluid enhances diagnostic efficacy in endoscopic biopsies of intracranial space-occupying lesions. ActaNeurochir (Wien). 2010, 152 : 111-117 (if=1.788, ci=2) 3. Husain N, Seema Awasthi, Mohd Haris, Rakesh K. Gupta, Mazhar Husain. Vascular endothelial growth factor as a marker of disease activity in neurotuberculosis. Journal of Infection 2008,56 : 114- 119 (if=3.72, ci=11) 4. Saksena S, Husain N, Das V, Pradhan M, Trivedi R, Srivastava S, Malik GK, Rathore RK, Sarma M, Pandey CM, Gupta RK. Diffusion tensor imaging in the developing human cerebellum with histologic correlation. Int J DevNeurosci. 2008 ,26 : 705-711. (if=2.65, ci=11) 5. Shukla N, Husain N, Jyotsna, Gupta S, Husain M. Comparisons between scolex and membrane antigens derived from Cysticercusfasciolaris and Cysticercus cellulose larvae in immunodiagnosis of human neurocysticercosis. J.MicrobiolImmunol Infect. 2008, 41 : 519-524. (if=1.75, ci=4) 6. Saksena S, Husain N, Malik GK, Trivedi R, Sarma M, Rathore RS, Pandey CM, Gupta RK. Comparative evaluation of the cerebral and cerebellar white matter development in pediatric age group using quantitative diffusion tensor imaging. Cerebellum. 2008, 7 : 392-400(if=2.89, ci=30) 7. Haris M, Husain N, Singh A, Awasthi R, Singh Rathore RK, Husain M, Gupta RK. Dynamic contrast- enhanced (DCE) derived transfer coefficient (ktrans) is a surrogate marker of matrix metalloproteinase 9 (MMP-9) expressions in brain tuberculomas. J Magn Reson Imaging 2008, 28 : 588-97 (if=2.79, ci=17) 8. Husain N. Carrier analysis for hemophilia A : ideal versus acceptable. Expert Rev. Mol Diagn 2009, 3 : 203-207 (if=4.27, ci=4) 9. Praveen Kumar, Nuzhat Husain, Priyanka Soni, Nuzhat Jahan Faridi, Sudhir Kumar Goel. New Protocol for Detection of Intron 22 Inversion Mutation from Cases With Hemophilia Clin Appl Thromb Hemost. Sep 19, 2013 (if=1.57, ci=1) 10. Raza ST, Husain N, Kumar A. Screening for hemophilia A carriers : utility of PCR-RFLP--based polymorphism analysis. Clin Appl Thromb Hemost 2009, 15 : 78-83 (if=1.57, ci=1)

397

KAKKAR, POONAM (b 1959), Chief Scientist & Area Coordinator (Regulatory Toxicology); Professor (AcSIR); Dy. TFM (In-charge) Toxicity Testing: GLP Test Facility; CSIR-Indian Institute of Toxicology Research, Lucknow

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Prof. Kakkar’s pioneering research showed mitochondrial damage by ROS/ oxidative stress as key phenomena in toxicity of drugs/chemicals and diabetes (Free Radic. Biol. Med, 1991). The highly sensitive method developed by her for estimation of superoxide dismutase (Ind. J. Biochem. Biophys., 1984); is the highest cited paper (2900 citations) of CSIR. She demonstrated for the first time hepato- protection by probiotics in acetaminophen induced apoptosis (Food Chem Toxicol,2011). Her novel approaches provided evidence for intervention by phytochemicals/ herbal extracts in redox mediated cellular signalling. She showed natural terpenes protected against redox imbalance and calcium dependent mitochondrial dysfunction in nimesulide-hepatotoxicity (PLoS One,2012). Regulation of carbohydrate metabolism by Berberis aristata extract in diabetic rats (J. Ethnophramacol, 2009) observed in vivo led to formulation of nanotized berberine which gave protection at low doses. More recently she reported berberine induced FoxO proteins’ nuclear retention, Bim/PUMA induction, mitochondrial dysfunction and apoptosis in HepG2 cells (FRBM,2014;TAAP,2016). She also reported essential role of PHLPP2 in suppression of redox sensitive transcription factor Nrf2 via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatotoxicity (Cell Death & Disease,2014) and its modulation by Morin (Redox Biol., 2015). She was a key member for development of pharmacopoeial standards of Ayurvedic drugs (API, 2006). Her observation of decline in antioxidant capacity of herbal teas during storage (Food Res. Int,2006) reiterated need for expiry date on herbal products. Her findings on safety of herbo-mineral Ayurvedic drugs and heavy metals in medicinal plants were cited by Government of India to rebut a US report. Proposer: Prof. P. K. Seth, Seconder: Prof. C. S.Nautiyal Ten Best Publications: 1. Kakkar P, Das B and Viswanathan PN (1984). A modified spectrophotometric assay of superoxide dismutase. Ind. J. Biochem. Biophys., 21: 130 132. (if=0.958, ci=2900) 2. Mehrotra S, Kakkar P and Viswanathan PN (1991). Mitochondrial damage by active oxygen species in vitro. Free Radical Biol. Med., 10: 277 285. (if=5.982, ci=57) 3. Naithani V, Nair S and Kakkar P (2006). Decline in antioxidant capacity of Indian herbal teas during storage and its relation to phenolic content. Food Res Int., 39: 176-181. (if=3.871, ci=69) 4. Singh J and Kakkar P (2009). Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. Journal of Ethnopharmacology, 123:22-26. (if=3.333, ci=125) 5. Singh BK, Tripathi M, Chaudhari BP, Pandey PK and Kakkar P (2012). Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide- hepatotoxicity in rats. PLoS One,7(4):e34200. (if=3.540, ci=58) 6. Sharma S, Singh RL and Kakkar P (2011). Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes. Food Chem. Toxicol., 49: 770-779 (if=3.440, ci=32) 7. Rizvi F, Shukla S and Kakkar P (2014). Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity. Cell Death & Disease, 5(3), e1 (if=5.378, ci=17) 8. Shukla S, Rizvi F, Raisuddin S and Kakkar P (2014). FoxO proteins’ nuclear retention and BH3- onlyprotein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells. Free Radical Biology & Medicine, 76:185-199 (if=5.982, ci=15) 9. Rizvi F, Mathur A, Krishna S, Siddiqi MI, Kakkar P (2015). Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes. Redox Biol., 6:587-598. (if=6.235, ci=3) 10. Shukla S, Sharma A, Pandey VK, Raisuddin S, Kakkar P (2016). Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 (if=4.010, ci=3)

398

KAR, SHANTANU KUMAR (b 1952), Director (Research) Medical & Life Sciences, RMRC, Bhubaneswar, Khurda

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr. S K Kar has devoted his entire career to medical research and made significant contributions to our understanding of tropical diseases and developed innovative chemotherapeutic and vaccine tools for the control and elimination of diseases of poverty. His 4 decades of research has influenced national and global policies of control and elimination of communicable diseases. Dr. Kar has a brilliant academic track record winning national and state merit scholarships including Talent Search scholarship of ICMR. His research career spanning over 35 years in the ICMR includes over 20 years as Director at RMRI, Patna and RMRC, Bhubaneswar. Dr. Kar has over 150 papers in national and international journals along with chapters in books. His major research contributions have been in the field of lymphatic filariasis including pioneering studies with lvermectin and DEC (Kar et. al, 1993, Acta Tropica 55: 21-31). Dr. Kar established a high quality mycobacteriology laboratory at RMRC Bhubaneswar that is a National Reference Laboratory for control of tuberculosis in eastern India (Satapathy et. al, 2014, Int J Mycobacteriol, 3(4), 290). After superannuation in year April 2015 from ICMR, he has been working as Director (research) medical & life sciences Under Siksha O Anusandhan University, 2015. During last 2 years he has initiated 3 research projects on TB, H Pylori and Acute encephalitis syndrome and guided several research faculties to initiate research projects and publications. Guiding 2 PhD scholars at RMRC, ICMR. Proposer: Dr. Sujit Kumar Bhattacharya, Seconder: Dr. Rama Murthy Ten Best Publications: 1. Kar SK, Patnaik, S, Mania J, Kumaraswamy V, Murty, RSN. Side reactions following Ivermectin therapy in high density BancroftianMicrofilaraemics. Acta Tropica 55: 21-31. (if=2.380, ci=6) 2. Babu BV, Kar SK.Coverage, compliance and some operational issues of mass drug administration during the programme to eliminate lymphatic Filariasis in Orissa, India. Tropical Medicine International Health 9(6): 702-709. (if=2.302, ci=83) 3. Kerketa AS………..Kar SK et al., A Randomized clinical trial tocompaire the efficacy of there treatment regimens along with foot care in morbidity management of filarial lymphoedema. Tropical Medicine and International Health 10: 698-750. (if=2.302, ci=2) 4. Bal MS, Mandal NN,Das MK, Kar SK, Sarangi SS, Beuria MK. Transplacental transfer of filarial antigens from Wuchereriabancroft-infected mothers to their offspring. Parasitology 23:1-5. (if=2.35, ci=12) 5. Das B, Das M, Dwibedi B, Kar SK, Hazra RK, 2013. Molecular investigations of dengue virus during outbreaks in Orissa state, Eastern India from 2010 to 2011. Infection Genetics Evolution 16:401-10. (if=3.264, ci=16) 6. Das D, Dwibedi B, Kar SK, 2014. Spot or early morning sample for mycobacterial culture: Which? International Journal Tuberculosis Lung Diseases 18(3):310-311. (if=2.148, ci=1) 7. Kar S.K., et al . A Randomized Controlled Trial of Increased Dose and Frequency of Albendazole with Standard dose DEC for Treatment of wuchereria bancrofti Microfilaremics in Odisha, India. PLOS Neglected Tropical Diseases. 2015; 9 (3). (if=4.446, ci=1) 8. Wierzba Thomas F., Kar Shantanu K., ...... et al. Effectiveness of an oral cholera vaccine campaign to prevent clinically-significant cholera in Odisha State, India. Vaccine.2015; 33 (21):2463-2469. (if=3.624, ci=9) 9. Mogasale Vittal, Kar Shantanu K., ...... et al. An Estimation of Private Household Costs to Receive Free Oral Cholera Vaccine in Odisha, India. PLOS Neglected Tropical Diseases. 2015; 9(9). (if=4.446, ci=1) 10. Bal MS, Sahoo PK, Mandal N, Satapathy AK, Ranjit M.R and Kar SK . Maternal infection is a risk factor for early childhood infection in filariasis. PLoS Negl Trop Dis. 2015; 8(2): e2629. (if=4.446, ci=1)

399

KUMAR, ARUN (b 1960), Professor, Dept. of Molecular Reproduction, Development & Genetics, Indian Institute of Science, Bangalore 560012

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Arun Kumar has made outstanding contributions in the area of human genetics and cancer biology. He has discovered the causative genes, STIL, TRIM36 and LTBP2, for primary microcephaly (small brain), anencephaly (no brain) and microspherophakia (small spherical lens), respectively (Am J Human Genet, 2009, 84:286-290; Human Mol Genet, 2017, 10.1093/hmg/ddx020; Human Genet, 2010, 128:365-371). He has investigated the nuclear function of a well-known tumor suppressor TSC2, which functions as a negative regulator of mTORC1 in complex with TSC1 in the insulin signaling pathway. He has shown that TSC2 also functions as a transcription factor and regulates the expression of epiregulin, a ligand for EGFR (Nucleic Acids Res, 2014, 42:6243-6255). He has further shown that the well-known WT1 functions as an oncogene in oral cancer and transcriptionally represses the tumor suppressor CDC73 (J Biol Chem, 2014, 289:968-976). CDC73 as part of the Paf1 complex remains associated with RNA polymerase II and regulates global gene expression. His work has shown that the dramatic upregulation of oncogenic miR-155 is an exclusive mechanism for downregulation of CDC73, and the restoration of CDC73 levels by antagomir-155 may have an important role in therapeutic intervention of cancers (J Biol Chem, 2013, 288:608-618). Further, he has also shown that the ESRRA gene is upregulated in oral cancer and is regulated by miR-125a, and decreasing the level of ESRRA by synthetic miR-125a mimics may have an important role in therapeutic intervention of oral and other cancers (J Biol Chem, 2014,289:32276-32290). Proposer: Prof. Bhudev C. Das, Seconder: Prof. Subrata Sinha Ten Best Publications: 1. Singh N, Bhat VK, Tiwari A, Kodaganur SG, Tontanahal SG, Sarda A, Malini KV and Kumar A. 2017. A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family. Human Mol Genet, DOI: 10.1093/hmg/ddx020. (if=5.985, ci=0) 2. Tiwari A, Shivananda S, Gopinath KS and Kumar A. 2014. microRNA-125a reduces proliferation and invasion of oral squamous cell carcinoma cells by targeting estrogen-related receptor alpha: Implications for cancer therapeutics. J Biol Chem, 289:32276-3 (if=4.258, ci=20) 3. Pradhan SA, Rather MI, Tiwari A, Bhat VK and Kumar A. 2014. Evidence that TSC2 acts as transcription factor and binds to and represses the promoter of epiregulin, Nucleic Acids Res, 42:6243- 6255. (if=9.202, ci=6) 4. Rather MI, Swamy S, Gopinath KS and Kumar A. 2014. Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by WT1 promotes cell proliferation: Implication for cancer therapeutics. J Biol Chem, 289:968-976. (if=4.258, ci=9) 5. Rather MI, Nagashri MN, Swamy SS, Gopinath KS and Kumar A. 2013. Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: Implications for cancer therapeutics. J Biol Chem, 288:608-618 (if=4.258, ci=58) 6. Bhat V, Girimaji SC, Mohan G, Arvinda HR, Singhmar P, Duvvari MR and Kumar A. 2011. Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations. Clinical Genet, 80:532-540. (if=3.892, ci= 31) 7. Kumar A, Duvvari MR, Prabhakaran VC, Shetty JS, Murthy GJ and Blanton SH. 2010. A homozygous mutation in LTBP2 causes isolated microspherophakia. Human Genet, 128: 365-371. (if=5.138, ci=36) 8. Kumar A, Girimaji SC, Duvvari MR and Blanton SH. 2009. Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly. Am J Human Genet, 84:286-290. (if=10.794, ci=183) 9. Chakraborty S, Mohiyuddin SMA, Gopinath KS and Kumar A. 2008. Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma. BMC Cancer, 8:163. (if=3.265, ci=84) 10. Kumar A, Blanton SH, Babu M, Markandaya M and Girimaji SC. 2004. Genetic analysis of primary microcephaly in Indian families: Novel ASPM mutations. Clinical Genet, 66:341-348. (if=3.892, ci=71)

400

MISRA, RAMNATH (b 1954) Dean, Professor and Head Department of Clinical Immunology, S.G.P.G.I.M.S, Lucknow

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

He has contributed to advance the knowledge of pathogenesis of Reactive arthritis , Systemic lupus erythematosus, Takayasu arteritis and Juvenile Idiopathic Arthritis. In salmonella induced Reactive arthritis he has shown the antigenic targets of synovial fluid T cells to be outer membrane protein (OMP) A of salmonella typhimurium. Recombinant OMP A stimulates synovial fluid mononuclear cells to produce IL-17, a proinflammatory cytokines which he described in SF of patients with ReA/uSpA earlier for the first time. ratory studies in have provided basic information ReA and related undifferentiated spondyloarthropathy (uSpA).This has a translational role in developing a diagnostic test for this disease and pave the way for targeted therapy to IL-17. In SLE he has described the long term outcome of patients with lupus nephritis, and recently showed a distinctive metabolomic signature in lupus nephritis could be utilized as a biomarker. In Takayau arteritis, he led a group Indian Rheumatology Association Vasculitis group (IRAVAS ) which validated a clinical instrument to measure disease activity in Takayasu arteritis (ITAS 2010). In TA, he along with collaborative scientist described a characteristic metabolomic signature by using NMR spectroscopy. Other notable contributions being observations of subclinical atherosclerosis in your Rheumatoid arthritis patients in our country and a different profile of children and adolescents with Juvenie idiopathic arthritis seen in India. He has therefore , made substantial contributions in the field of clinical immunology and rheumatology. He is a pioneer in establishing this branch of Medicine in our country. Proposer : Prof Rakesh Kapoor, Seconder : Prof U K Misra Ten Best Publicatons : 1. Guleria A, Pratap A, Dubey D, Rawat A, Chaurasia S, Edvalath S, Phatak S, Ajmani S, Kumar A, Khetrapal CL, Bacon PA, Misra R, Kumar D. NMR based serum metabolomics reveals a distinctive signature in patients with Lupus Nephritis. Sci. Rep. 6, 35309; doi: 10.1038/srep35309 (2016). IF= 5.228 CI=0 2. Guleria A, Misra DP, Rawat R, Dubey D, Khetrapal CL, Bacon PA, Misra R, Kumar D. NMR based serum metabolomics discriminates Takayasu Arteritis from Healthy Individuals. J Proteom Research 2015;14:3372-81. IF= 4.341 CI=3 3. Misra R, Danda D, Rajappa SM, Ghosh A, Gupta R, Mahendranath KM, et al. Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Rheumatology (Oxford). 2013;52:1795-801. PubMed PMID: 23594468.. IF= 4.524 CI=44. 4. Dhir V, Aggarwal A, Lawrence A, Agarwal V, Misra R. Long-term outcome of lupus nephritis in Asian Indians. Arthritis Care Res (Hoboken). 2012;64:713-20. IF= 4.641 CI=12 5. Singh R, Shasany AK, Aggarwal A, Sinha S, Sisodia BS, Khanuja SP, et al. Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. ClinExpImmunol. 2007;148:486-93. IF= 3.21 CI=24 6. Singh R, Aggarwal A, Misra R. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J Rheumatol. 2007 ;34:2285-90. IF= 3.316 CI=85 7. Aggarwal A, Misra R. Juvenile chronic arthritis in India: is it different from that seen in Western countries? Rheumatol Int. 1994;14:53-6. 3 IF= 1.702 CI=43 8. Misra R, Aggarwal A, Chag M, Sinha N, Shrivastava S. Raised anticardiolipinantibodies in Takayasu's arteritis. Lancet. 1994 Jun 25;343(8913):1644-5. IF= 44.002 CI=32 9. Grover S, Sinha RP, Singh U, Tewari S, Aggarwal A, Misra R.Subclinical atherosclerosis in rheumatoid arthritis in India. J Rheumatol. 2006;33:244-7. IF= 3.17 CI= 64 10. Misra R, Darten K, Jewkes RPF, Black CM, Maini RN. Arthritis in scleroderma. Brit J Rheumatol (Rheumatology) 1995;34:831-7. IF= 4.44 CI=64

401

PATURU, KONDAIAH (b 1954), Professor, Dept. of MRDG, Indian Institute of Science, Bangalore

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Prof. Kondaiah is an established and highly accomplished Cancer Biologist. He made seminal contributions towards the understanding of signaling pathways involved with fibrosis, breast cancer and glioma. His laboratory extensively used microarrays as a tool to understand the pathways involved in TGF-beta signaling, breast cancer prognosis, etio-pathogenesis of oral submucous fibrosis and role of IGFBPs in progression of breast cancer and glioma. His group demonstrated differential regulation of genes by TGF-beta in normal and tumor cells demonstrated the differential activation of non canonical and MAPK signaling in tumor and non tumor cells by TGF-beta. This work resulted in the identification of S100A2 as an intermediate in TGF-beta actions. Using a variety of in vitro and in vivo experiments the role of S100A2 has been demonstrated in the progression of cancers. Activation of TGF-beta1 by laser and a mechanism for faster healing of soft tissues was also an interesting demonstration by his group. With respect to glioma, a role for IGFBP 2,3 and 4 isoforms in glioma progression has been proposed and demonstrated the importance of IGFBP2 actions in the regulation of bet-catenin. This work identified IGFBP2 as an important therapeutic target for glioblastoma. Importantly, his group elucidated the mechanism of areca nut induction of TGF-beta pathway that has enormous implications in the etiology of Oral Submucous Fibrosis. Significantly, his group along with chemists identified a small molecule which acts on mutant form of p53 resulting in wild type conformation and activates the p53 dependent apoptosis. Proposer: A. Jagannadha Rao, Seconder: Rajan R. Dighe Ten Best Publications: 1. Ranganathan P, Agrawal A, Bhushan R, Chavalmane CK, Kalathur RK, Takahashi T, Kondaiah P*. Expression profiling of genes regulated by TGF-beta: Differential Regulation in Normal and Tumor cells BMC Genomics Apr 11; 8(1):98 2007. (if=4,1, ci=55) 2. Arany PR, Nayak RS, Hallikerimath S, Limaye AM, Kale AD, Kondaiah P* 2007. Activation of Latent TGF-β1 by low power laser in vitro correlates with increased TGF-β1 levels in laser enhanced oral wound healing Wound Repair Regen. 15(6):866-74 (if=2.768, ci=46) 3. Reddy PS, Britto R, Vinnakota K, Aparna H, Sreepathi HK, Thota B, Kumari A, Shilpa BM, Vrinda M, Umesh S, Samuel S, Shetty M, Tandon A, Pandey P, Hegde S, Hegde AS, Balasubramaniam A, Chandramouli BA, Santhosh V, Kondaiah P*, Somasundaram K*, Rao (if=8.738, ci=70) 4. Santosh V, Arivazhagan A, Sreekanthreddy P, et al. 2010. Grade specific expression of IGFBP-2, -3 and -5 in astrocytomas--- Cancer Epidemiol. Biomarkers & Prev. 2010 19(6):1399-1409 (if=3.622, ci=39) 5. Khan I, Agarwal P, Thangjam GS, Radhesh R, Rao SG and Kondaiah P*.2011..Role of TGF-β and BMP7 in the pathogenesis of oral submucous fibrosis. Growth Factors, 29(4):119-27 (if=2.92, ci=22) 6. 6. Naz S, Ranganathan P, Bodapati P, Shastry AH, Mishra LN, Kondaiah P*. Regulation of S100A2 Expression by Transforming Growth Factor-β induced MEK/ERK Signaling and its role in Cell Migration/Invasion. Biochem J. 447(1):81-91 2012 (if=4.654, ci=19) 7. 7. Naz S, Bashir M, Ranganathan P, Bodapati P, Santosh V and Kondaiah P*. Pro tumorigenic actions of S100A2 involves regulation of PI3/Akt signaling and functional interaction with Smad3. Carcinogenesis. 35(1):14-23. 2013 (if=5.334, ci=10) 8. Sehgal P, Kumar N, Praveen Kumar VR, et al 2013 Regulation of protumorigenic pathways by Insulin like growth factor binding protein2 and its association along with β-catenin in breast cancer lymph node metastasis. Mol Cancer. 12(1):63, 2013 (if=5.88, ci=14) 9. Patil SS, Priyanka G, Bashir M, S et al 2016 (Nov). Insulin like Growth Factor Binding Protein-2 regulates β-catenin signaling pathway in glioma cells and together contribute poor patient prognosis. Neuro-Oncol, 18(11):1487-1497 (if=7.371, ci=0) 10. Pant I, Rao SG and Kondaiah P*: 2016. Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis. Sci Rep. 2016 Oct 6;6:34314. (if=5.22, ci=0)

402

REDDY SHETTY, PRAKASHAM (b. 1960) Senior Principal Scientist, IICT, Hyderabad

Member of the NASI : No (YON 2015, Medical & Forensic Sciences)

-Developed hydrogels and evaluated the bioefficacy of alpha glucans, serralysin as anti-inflammatory, fibrinolytic, anti-microbial and wound-healing agents -Unraveled the involvement of two ammonium transport systems and their regulatory role in inhibition/stimulation of ammonium/glutamate transport -Decoupling of biomass growth and its bioproduct production by modulating cellular metabolism to develop a recycle and reusable biocatalyst and to improve bioethanol process. -Functionalization of biopolymer, ferric/nickel impregnated silica nanoparticles and understanding its robustness as well as evaluation of its role as immobilizing matrix in enantioselective lactic acid production - used in biopolymer production -Evaluating the Taguch methodology as a statistical tool for biotechnological applications for first time. -Unraveling the role of barbital in modulation of metabolism linked to improved production (120%) of rifamycin in Nocardia strain and understanding the alkaline. protease production kinetics and developing the a mathematical model -Developed rapid bioprocesses for silver nanoparticles, xylooligosaccharides, fructooligosaccharides, polygalacturonasem, prodigiosin wine, L-asparaginase, L-glutaminasee, proteases, serralysin, L-lactic acid, rifamycin, actinomycin, epothelon, tyrosinase, xylanase, xylitol and defloridation using untapped agroindustrial materials. -Understanding of, glucose to xylose ratio, high biomass and sweet sorghum juice for effective biohydrogen as well as bioethanol production from lignocellulosic biomass. -Heterologous expression of CYP I 02A5 variant and its production as well as predicting drug metabolism of human P450 probe substrates and in silico molecular docking of prodigiosin and cycloprodigiosin as COX-2 inhibitors -Evaluating the functionalized polyamide membrane for treating the bulk drug industrial effluent. -Demonstrated the technologies (xylitol from biomass, xanthan gum, ethanol, and xylose) to industries. Proposer : Prof. Appa Rao Podile, Seconder : Prof. P.B. Kavi Kishor Ten Best Publications : 1. R S Prakasham, J Sheno Merrie, R Sheela, N Saswathi and S V Ramakrishna. 1999. Biosorption of chromium VI by free and immobilized Rhizopus arrhizus. Environ. Pollution (UK), 104/3,421- 427. IF- 3.902: CI = 204 2. R S Prakasham, Ch Subba Rao and P N Sarma. 2006. Green gram husk as innovative and inexpensive support for alkaline protease production by isolated Bacillus sp. under solid-state fermentation. Bioresource Technology, 97,1449-1454. IF-5.039: CI = 164 3. R S Prakasham, Sarala Devi, K Rajya Laxmi and Ch Subba Rao. 2007. Novel Synthesis of Ferric Impregnated silica nanoparticies and their evaluation as matrix for enzyme immobilization. J Phys. Chern. C. 111,3842-3847. IF-4.835: CI = 38 4. P Brahmaiah, Ch Subba Rao, T Satish and R S Prakasham. 2013. Heterologous expression of CYP102A5 variant from Bacillus cereus CYPPB- J: Validation of model for predicting drug metabolism of human P450 probe substrates. Appl Microbiol Biotechnol. 97, 8107-8719 -IF 3.811 5. B. VenkataSwamy, M. Madhumala, R.S. Prakash am, S. Sridhar. 2013. Nanofiltrationof Bulk Drug Industrial Effluent using Indigenously Developed Functionalized Polyamide Membrane. Chemical Engineering 1. 233,193-200. IF-3.473: CI = 2 6. P Laxmi Bharghavi and R S Prakasham. 2013. A fibrinolytic, alkaline and thermostable metalloprotease from the newly isolated Serratia sp RSPB II. International Journal of Biological Macromolecules. 61,479-486. IF - 3.227: CI = 3 7. B Sudheer Kumar, V V N Yaswanth, R S Prakasham. 2015. Fibrinolytic, anti-inflammatory and anti- microbial properties of a-(l-3)-glucans produced from Streptococcus mutans (MTCC497). Carbohydrate Polymers, 115, 152-159. IF-3.916. 8. AA Murthy, ML Kantam, B Jagadeesh, SV Phani Babu, Bhargava, B Sudheer Kumar, RS Prakasham. Ce/Si02 composite as an efficient catalyst for the muiticomponent one-pot synthesis of substituted pyrazolones in aqueous media and their antimicrobial activities. Journal of Molecular Catalysis A: Chemical 411 (2016) 325-336 IF-3.615 9. P Ramesh, K Srinivasa Rao, R Trivedi, B Sudheer Kumar, R S Prakasham, B Sridhar. Highly efficient regio and diasteroselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties. RSC Advances, 2016 in press. IF-3.84, DOl: 10.1039/C6RA00613B 10. C Sushma, V Venkata Dasu, J Ahmad, R S Prakasham. High yield expression of novel glutaminase free L-asparaginase II of Pectobacterium carotovorum MTCC1428 in Bacillus subtilis WB800N. Bioprocess Biosys Engg. 38,2015,2271-2284. IF - 1.997

403

SHARMA, AMAN (b 1974), Associate Professor, Internal Medicine, PGIMER, Chandigarh

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr. Aman Sharma has been working in the area of Rheumatology, Uveitis and Extrapulmonary tuberculosis. His main interest has been in rare rheumatic diseases like relapsing Polychondritis where he described how the clinical manifestations are different in Indian patients with less larynotracheal involvement (Scan J Rheumatol 2007,Orphanet J Rare Dis. 2014) and reported treatment of airway and aortic root involvement (Med J Aust 2007, Clin Rheumatol 2013). He was involved in developing Relapsing Polychondritis Disease Activity Index (RPDAI) (Autoimmun rev 2012). He validated the consensus methodology algorithm in patients with systemic vasculitis (Int J Rheum Dis 2013), described unknown manifestations (Int J Rheum Dis 2014) and relationship of histopathological classification of paucimmune GN with outcome (Rheumatol Int 2014). He is the local PI of the ongoing ACR EULAR study for development of diagnostic criteria of vasculitis (DCVAS, Clin Exp Immunol. 2011). He described the predictors of mortality in SLE (Lupus 2013) and Primary Pyomyositis (Clinical Rheumatol 2010). He showed that there is increased metabolic syndrome (Int J Rheum Dis 2013) and endothelial dysfunction in Indian patients with Psoriatic Arthritis (Int J Rheum Dis, in press). He has also been closely associated in collaborative research in uveitis [description of clinical signs of TB uveitis (Am J Ophthal 2010), Spectral OCT findings (Am J Ophthal 2009), Classification of ocular TB (Ocular Immunol Inflamm 2014), TB serpeginoid choroiditis (Ophthalmology 2012), detection of TB genome in ocular fluid (Ophthalmology 2015)] and molecular diagnosis of extrapulmonary tuberculosis (J Neurol 2010, Int Ortho2010). Proposer : Prof. Arunaloke Chakrabarti, Seconder : Dr. Javed N Agrewala Ten Best Publications: 1. Sharma A 2007 Relapsing polychondritis in North India Scand J Rheumatol 36 (6) 462-5 (if=2.61, ci=17) 2. Sharma A 2010 Ocular signs predictive of tubercular uveitis Am J Ophthal 149(4) 562-70 (if=4.02, ci=75) 3. Sharma A 2010 Clinical characteristics and predictors of mortality in 67 patients with Primary pyomyositis: A study from North India. Clin Rheumatol 29(1) 45-51 (if=1.774, ci=21) 4. Sharma A 2010 Successful treatment of hypertrophic pachymeningitis in refractory Wegener’s granulomatosis with rituximab Clin Rheumatol 29(1) 107-10 (if=1.774, ci=21) 5. Sharma A 2011 Multiplex PCR for rapid diagnosis of tuberculous meningitis J Neurol 258(10) 1781- 7 (if=3.841, ci=41) 6. Sharma A 2012 Tubercular serpiginous-like choroiditis presenting as multifocal serpiginoid choroiditis Ophthalmology 119(11): 2334-42 (if=6.17, ci=29) 7. Sharma A 2012 The Relapsing Polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis Autoimmun rev 12(2) 204-9 (if=7.1, ci=16) 8. Sharma A 2013 Causes of mortality among inpatients with systemic lupus erythematosus in a tertiary care hospital in North India over a 10-year period Lupus 22(2) 216-22 (if=2.481, ci=7) 9. Sharma A 2013 The Metabolic Syndrome in Patients of Psoriatic Arthritis: A Cross-sectional Study. Int J Rheum Dis 16(6) 667-73(if=1.771, ci=4) 10. Sharma A 2014 Relapsing Polychondritis: Clinical presentations, disease activity and outcomes Orphanet J Rare Dis. 9(1) 198(if=3.96, ci=-)

404

SINGH, SUNIT KUMAR (b 1971), Associate Professor, Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi

Member of the NASI : No (YON 2015, Medical & Forensic Sciences)

Dr. Sunit K. Singh has completed his Ph.D in the area of Infection Biology from University of Wuerzburg, Wuerzburg, Germany and postdoctoral trainings from Yale University School of Medicine, New Haven, USA and University of California, Davis, USA. Dr. Singh served as faculty member (Scientist) at CCMB, Hyderabad. Currently, Dr. Singh is working as Associate Professor (Molecular Immunology) at the Molecular Biology Unit, Institute of Medical Sciences, BHU, Varanasi. My interest in Dr. Singh reflects his ability to work across different types of viruses, including retroviruses (HIV-1), alphaviruses, and flaviviruses. Dr. Singh has published excellent papers in internationally reputed peer reviewed journals in the area of molecular virology. Dr. Singh has published excellent research papers in the peer reviewed international journals such as “Lancet Infectious Diseases”, “The Journal of Neuroscience”, BMC Neuroscience”, Annals of Rheumatic Diseases “Journal of Neuroinflammation” and many others. He has received FEBS Top cited Paper Award” by the peer reviewed journal “The FEBS journal”. Dr. Singh has edited four important books titled : Neuroviral infections (two volumes), book titled “Viral Hemorrhagic Fevers” and book titled “Human Respiratory Viral Infections” published by CRC/Taylor & Francis publication, USA and fourth book titled “Viral Infections and Global Change” by Willey Blackwell, USA. Dr. Singh has excelled with fundamental leadership quality in his area of work, which is very much related to the health and well-being of the population of this country. Therefore, I strongly nominate Dr. Sunit Kumar Singh for fellowship of the National Academy of Sciences of India. Proposer : Prof. Lalji Singh, Seconder : Dr. Ten Best Publications : 1. Sunit K. Singh and H. J. Girschick, 2004, Molecular survival strategies of the Lyme disease spirochete Borrelia burgdorferi; Lancet Infectious diseases, 4(9) : 575-583. (if=19.446, ci=76) 2. H. Morbach, Sunit K. Singh, C. Faber, A. Grammer, P. E. Lipsky, H. J. Girschick, 2005, Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood Systemic Lupus Erythematosus. Annals of Rheumatic Diseases,65(4) : 482-7.(if=9.720, ci=19) 3. R Mishra, C Chhatbar and Sunit K. Singh, 2012, HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia, Journal of Neuroinflammation, 18;9 : 131 (if=4.90, ci=16) 4. R Mishra, and Sunit K. Singh, 2013, HIV-1 Tat C modulates expression of miRNA-101 to suppress VE- Cadherin in Human Brain Microvascular Endothelial Cells, The Journal of Neuroscience 33(14) : 5992- 6000; doi : 10.1523/JNEUROSCI.4796-12.2013, (if=6.747, ci=12) 5. Gunjan Dhawan Manocha, Ritu Mishra, Nikhil Sharma, Kanhaiya Lal Kumawat, Anirban Basu, Sunit K. Singh, 2014, Regulatory role of TRIM21 in type-I interferon pathway in Japanese encephalitis virus infected human microglial cells Journal of Neuroinflammation doi : 10.1186/1742-2094-11-24. (if=4.90, ci=3) 6. Ritu Mishra, Sunit K. Singh, 2014, HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability, BMC Neuroscience 2014 Jun 26;15(1) : 80. doi : 10.1186/1471-2202-15-80). (if=2.85, ci=Paper published in year 2014 therefore citations yet to received (Highly accessed as per Journal Record)) 7. Sakthi Priya Selvamani, Ritu Mishra, Sunit K. Singh, 2014, Chikungunya virus exploits miR-146a to regulate NF-ҡB pathway in human synovial fibroblasts, PLoS One. 2014 Aug 1;9(8) : e103624. doi : 10.1371/journal.pone.0103624. (if=3.730, ci=4) 8. Vaishnavi Jadhav; Karl-Heinz Krause; Sunit K. Singh, 2014, HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in Human Microglial Cells, J Neurochem. 2014 Dec;131(6) : 803- 15. (if=4.244, ci=Paper published in year 2014 therefore citations yet to received) 9. D. Růžek, J. Salát, SK. Singh, and J. Kopecký, 2011 Breakdown of the Blood-Brain Barrier During Tick-Borne Encephalitis in Mice Is Not Dependent on CD8+ T-cells PLoS One. 2011;6(5) : e20472 doi : 10.1371/journal.pone.0020472. (if=3.730, ci=33) 10. Nikhil Sharma, Ruhi Verma, Kanhaiya L Kumawat, Anirban Basu and Sunit K Singh, 2015, miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells, Journal of Neuroinflammation (In press) DOI 10.1186/s12974-015-0249- 0. (if=4.90, ci=Paper published in year 2014 therefore citations yet to received (Highly accessed as per Journal Record))

405

TOTEJA, GURUDAYAL SINGH (b 1958), Director, Desert Medicine Research Centre (ICMR), Jodhpur; Scientist-‘G’ & Head (Nutrition), Indian Council of Medical Research, New Delhi and Head, Centre for Promotion of Nutrition Research and Training..(ICMR), 3 Red Cross Road, New Delhi

Member of the NASI: No (YON 2015, Medical & Forensic Sciences)

Dr. Toteja, Ph. D., FAMS has 36 years of research experience in biomedical sciences and have addressed several issues of public health importance which have either benefited population directly or had significant impact on policy and programmes of Government. Recent initiatives include launch of research project with Rajasthan Government on Self Breast Examination for early detection of cancer in all 33 districts of Rajasthan covering 1.65 crores women aged 30 to 60 years; Screening of tribal children for sickle cell disease (already screened 30,000 children). Appropriate intervention is being carried out and screening of 4,00,000 tribal population is continuing. A project on Silicosis has been initiated in 12 districts of Rajasthan. Two new Task Forces have been initiated on Fluorosis and Iodine Deficiency Disorders in 17 locations. Ongoing activities include 41 districts project in 20 states including all 8 north east states on malnutrition and 10 districts project in nine states on hypertension. Dr. Toteja is also working on sustainable approach for facilities developed for diagnosis of H1N1 and Zika virus. He has established centres on Tribal Health, Bioinformatics, Model Rural Health Research Unit and Nutrition which include NABL accredited Clinical Biochemistry Laboratory. The other notable contribution made by him is to promote research among medical colleges of Rajasthan in collaboration with them and Government of Rajasthan. His past contribution has led to fixing of maximum residue limits for pesticide residues by FSSAI for food commodities/ products Proposer: Dr. Ravinder Goswami, Seconder: Dr. Jaya S Tyagi Ten Best Publications: 1. Bansal PG, Toteja GS, Bhatia N, Gupta S, Kaur M, Adhikari T, Garg AK. Comparison of haemoglobin estimates using direct & indirect cyanmethaemoglobin methods. Indian J Med Res 2016;144(4):566-71 (if=1.446, ci=0) 2. Bansal PG, Toteja GS, Bhatia N, Siddhu A, Vikaram NK. Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls-a randomized clinical trial. European Journal of Clinical Nutrition , (23 December 2015) | (if=2.709, ci=2) 3. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; for the Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, (if=45.217, ci=27) 4. Jain P, Gulati S, Toteja GS, Bakhshi S, Seth R, Pandey RM. Serum Alpha Tocopherol, Vitamin B12, and Folate Levels in Childhood Acute Lymphoblastic Leukemia Survivors With and Without Neuropathy. J Child Neurol. 2014 pii: 0883073814535495 (if=1.385, ci=3) 5. Agarwal R, Virmani D, Jaipal M, Gupta S, Sankar MJ, Bhatia S, Agarwal A, Devgan V, Deorari A, Paul VK, Toteja GS; Investigators of the LBW Micronutrient Study Group. Poor zinc status in early infancy among both low and normal birth weight infants and (if=2.649, ci=9) 6. Siruguri V, Kumar PU, Raghu P, Rao MV, Sesikeran B, Toteja GS, Gupta P, Rao S, Satyanarayana K, Katoch VM, Bharaj TS, Mangat GS, Sharma N, Sandhu JS, Bhargav VK, Rani S. Aflatoxin contamination in stored rice variety PAU 201 collected from Punjab, In (if=1.396, ci=12) 7. T. Longvah, G.S. Toteja, G. Bulliyya,R.S. Raghuvanshi, Shashi Jain, Vishnuvardhan Rao, A. Upadhya. Stability of added iodine in different Indian cooking processes. Food Chemistry 2012;130(4):953–959 (if=3.391, ci=12) 8. Sharma SK, Puri R, Jain A, Sharma MP, Sharma A, Bohra S, Gupta YK, Saraya A, Dwivedi S, Gupta KC, Prasad M, Pandey J, Dohroo NP, Tandon N, Sesikeran B, Dorle AK, Tandon N, Handa SS, Toteja GS, Rao S, Satyanarayana K, Katoch VM. Assessment of effects (if=1.396, ci=21) 9. Ganguly NK, Bhattacharya SK, Sesikeran B, Nair GB, Ramakrishna BS, Sachdev HP, Batish VK, Kanagasabapathy AS, Muthuswamy V, Kathuria SC, Katoch VM, Satyanarayana K, Toteja GS, Rahi M, Rao S, Bhan MK, Kapur R, Hemalatha R. ICMR-DBT guidelines for eval (if=1.396, ci=27) 10. Toteja GS, Singh P, Dhillon BS, Saxena BN, Ahmed FU, Singh RP, Prakash B, Vijayaraghavan K, Singh Y, Rauf A, Sarma UC, Gandhi S, Behl L, Mukherjee K, Swami SS, Meru V, Chandra P, Chandrawati, Mohan U. Prevalence of anemia among pregnant women and ado (if=1.148, ci=176)

406

ADIGA, SATISH KUMAR (b 1967), Professor, Division of Clinical Embryology, Manipal University, Manipal

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Recently, concern has been expressed about the influence of sperm DNA integrity on the abnormal reproductive outcome. Although infertile men may father children with assisted conception, fertilization with DNA-damaged spermatozoa may increase the risk of genetic abnormalities in offspring (Adiga et al., 2010). For the first time, a study from nominee’s laboratory has revealed that advanced age and poor quality ejaculates carry spermatozoa with increased DNA fragmentation (Varshini, et al., 2011). However, the DNA fragmentation in the spermatozoa can be effectively eliminated by split ejaculate approach (Kumar et el., 2011) or by supplementing the antioxidants such as vitamin E (Kalthur, et al., 2011). The results of these studies established that the genetic and epigenetic integrity of sperm DNA can be affected by various endogenous and exogenous factors (Adiga et al., 2011). The embryos derived from the DNA damaged sperm show unique damage response pathways (Adiga et al., 2007). However, recent developments in the area of metabolomics are expected to help IVF professionals in selecting healthy embryos (Pudakalakatti, et al., 2013) which have the potential to implant and benefit infertility patients. Considering the fact that in India, male factor infertility remains a significant problem contributing 50% of cases attending infertility clinics and its assessment still relies on the traditional semen analysis, which does not address integrity of the male genome the contributions of Prof.Adiga to assess the level of sperm DNA integrity on the embryonic response and risk associated with fertilizing the oocytes with DNA damaged sperm are of great significance. Proposer : Prof. A. Jagannadha Rao, Seconder : Prof. Polani B Seshagiri Ten Best Publications: 1. Kumar D, SalianSR, Kalthur G, Uppangala S, Kumari S, Challapalli S, Chandraguthi SG, Hanumanthappa K, Jain J, Kumar P, Adiga SK. Semen abnormalities, sperm DNA damage and global hypermethylation in health workers occupationally exposed to ionizing radiation PLoS One. 2013 Jul 29;8(7):e69927 (if=3.7, ci=0) 2. Pudakalakatti SM, Uppangala S, D'Souza F, Kalthur G, Kumar P, Adiga SK, Atreya HS. NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential. NMR Biomed. 2013, 26: 20-7. (if=3.5, ci=3) 3. Salian SR, Kalthur G, Uppangala S, Kumar P, Adiga SK. Frozen-thawed spermatozoa from oligozoospermic ejaculates are susceptible to in situ DNA fragmentation in polyvinylpyrrolidone-based sperm-immobilization medium. Fertil Steril. 2012 Aug., 98: 321-5. (if=4.01, ci=3) 4. Adiga SK, Ehmcke J, Schlatt S, Kliesch S, Westernströer B, Luetjens CM, Wistuba J, Gromoll J. Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status. Mol Hum Reprod, 2011, April 11. PMID: 21482616 (if=4.5, ci=3) 5. Adiga SK, Upadhya D, Kalthur G, Rao S, Kumar P Transgenerational changes in somatic and germ line genetic integrity of first generation offspring derived from the DNA damaged sperm. Fertil Steril. 2010 May 15;93(8):2486-90. (if=4.01, ci=18) 6. Kalthur G, Adiga SK, Upadhya D, Rao S, Kumar P. Effect of cryopreservation on sperm DNA integrity in patients with teratospermia. Fertil Steril. 2008 Jun; 89(6):1723-7. (if=4.01, ci=35) 7. Adiga SK, Shimura T, Toyoshima T, Taga M, Inoue M, Niwa O. p21 provides stage specific DNA damage control to preimplantation embryos. Oncogene 2007 Sep 13;26(42):6141-9. (if=7.3, ci=17) 8. Adiga SK, Toyoshima T, Shimura T, Takeda J, Uematsu N, Niwa O. Delayed and stage specific phosphorylation of H2AX during preimplantation development of gamma-irradiated mouse embryos Reproduction, 2007, 133(2):415-22. (if=3.55, ci=25) 9. Shimura T, Toyoshima M, Adiga SK, Kunoh T, Inoue M, Niwa O. The role of P53 assisted ATM dependent phosphorylation of PCNA in the low dose specific S-checkpoint in mammalian cells Oncogene, 2006 Sep 28;25(44):5921-32 ( (if=7.3, ci=15) 10. Toyoshima M, Shimura T, Adiga SK, Taga M, Shiraishi K, Inoue M, Yuan ZM, Niwa O. Transcription independent suppression of DNA synthesis by p53 in sperm irradiated mouse zygotes 2005 Oncogene; 24: 3229-3235 (if=7.3, ci=9)

407

BASHYAM, MURALI DHARAN (b 1969), Staff Scientist VI, Centre for DNA Fingerprinting and Diagnostics, Hyderabad

Member of the NASI: Yes (YON 2014, Medical & Forensic Sciences)

Though scientific research in India has resulted in several seminal advancements in the field of basic biology, achievements in medical research have been fewer. In this respect, the nominee’s pioneering contributions in the field of translational cancer research deserve to be recognized. His efforts on sporadic colorectal cancer (CRC) identified non-canonical tumorigenesis pathways in early-onset rectal cancer, the predominant but least understood CRC subtype in India. In parallel, his work on familial CRC revealed mismatch repair (MMR) expression proficient Lynch Syndrome-associated colorectal tumors despite presence of MMR gene lesions. His discoveries therefore challenge the well-established CRC dogmas and highlight the caution to be exercised while replicating patient treatment and management regimes developed in the West. The nominee’s seminal work on squamous carcinoma of the esophagus and oral tongue has identified unique gain of oncogenic function activities of TP53 missense mutations, unraveling therefore novel therapeutic options. His efforts utilizing genome-wide DNA and RNA profiling followed by methylation, tissue microarray and functional analysis identified novel pancreatic cancer suppressor genes providing efficient options for targeted therapy. The nominee has made significant contributions in the field of medical genetics as well. He performed the first ever molecular characterization of several genetic disorders from the Indian population including but not limited to Phenylketonuria, Farber disease, Hypohidrotic/Anhidrotic Ectodermal Dysplasia and Maple Syrup Urine Disease that not only revealed a unique mutation profile distinct from other populations but also resulted in a paradigm shift from the mutant protein to the mutated gene transcript. Proposer: Dr J Gowrishankar, Seconder: Dr Ranjan Sen Ten Best Publications: 1. AK Chaudhary, VH Sankar and MD Bashyam. 2016. A novel large deletion that encompasses EDA and the downstream gene AWAT2 causes X-linked hypohidrotic/anhidrotic ectodermal dysplasia. J Dermatol Sci, 84:105-107. (if=3.7, ci=1) 2. Bashyam MD, Kotapalli V, Raman R, et al. 2015. Evidence for presence of Mismatch Repair gene expression positive Lynch syndrome cases in India. Mol Carcin, 54:1807-1814. (if=4.7, ci=0) 3. RSR Adduri, R Katamoni, R Pandilla, SN Madanaa, AK Paripati, V Kotapalli, MD Bashyam. 2014. TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in esophageal cancer in India. Plos One, 9:e114002. (if=3.2, ci=2) 4. MD Bashyam, AK Chaudhary, M Kiran, et al. 2014. Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation. Clin Genet, 86:530-538. (if=3.9, ci=6) 5. Ratheesh R, V Kotapalli, R Adduri, et al. 2014. Evidence for possible non-canonical pathway(s) driven early-onset colorectal cancer in India. Mol Carcin, 53:E181–E186. (if=4.7, ci=16) 6. MD Bashyam, AK Chaudhary, M Kiran, et al. 2014. Splice, insertion-deletion and nonsense mutations that perturb the Phenylalanine hydroxylase transcript cause Phenylketonuria in India. J Cellular Biochem, 115:566-574. (if=3.5, ci=1) 7. Khursheed M, Kolla JN, Kotapalli V, et al. 2013. ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines. Br J Cancer; 108:2056-2062. (if=5.6, ci=25) 8. MD Bashyam, AK Chaudhary, EC Reddy, et al. 2012. A founder Ectodysplasin A receptor (EDAR) mutation results in a high frequency of the autosomal recessive form of Hypohidrotic Ectodermal Dysplasia in India. Br J Dermatol, 166:819-829. (if=4.3, ci=15) 9. Kevin A. Kwei*, MD Bashyam*,#, J Kao, et al. 2008. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLOS-Genet, 4:e1000081 (shared *first and #senior authorship). (if=6.7, ci=60) 10. Bashyam, MD. 2002. Understanding cancer metastasis: An urgent need for using differential gene expression analysis. Cancer, 94:1821-1829. (if=5.7, ci=69)

408

BASU, SANDIP (b 1971), Head, Nuclear Medicine Academic Programme, Consultant Nuclear Medicine Physician and Scientific Officer-F Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Center Annexe, Jerbai wadia Road, Parel, Mumbai-400012, India. Dean-Academic (Health Sciences), BARC, Homi Bhabha National Institute

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Sandip Basu made distinguished contributions to the field of Nuclear Medicine by integrating functional radionuclide imaging and therapy for individualized patient management. His focus is on patient services, medical education and clinical research. Dr. Basu assumed responsibility of successful functioning of the India’s first PET machine and devised several outstanding ways to advance routine and novel applications of unsealed radionuclide sources for the benefit of patients, at the Radiation Medicine Centre. He has been instrumental in initiation of several therapeutic services such as Peptide Receptor Radionuclide therapy with 177Lu-DOTATATE for Neuroendocrine tumors and therapy for metastatic thyroid carcinoma or diagnostic services such as rhTSH primed I131 scan and FDG based detection of infection and inflammation. His vast clinical experience has been translated into enrichment of literature in oncology and molecular imaging that has enhanced the understanding of molecular basis of human pathophysiology. He has published 263 papers on comprehensive patient data (original communications), rare cases (Clinical Case Reports or Technical Notes), innovative hypotheses (Editorials or Letters) and impressive reviews in high impact factor peer reviewed indexed international journals and text book chapters. He has been involved in teaching, training and assessment of PG students in Nuclear Medicine. He has delivered about 66 invited lectures in national/international conferences in addition to 104 scientific abstracts in peer reviewed meetings. He has been a recipient of several awards, prominent among them being prestigious Shanti Swarup Bhatnagar Prize in Medical Sciences (2012) and DAE Scientific and Technical Excellence Award (2007). Proposer : Dr. Kanjaksha Ghosh, Seconder : Dr. Shree Kumar Apte Ten Best Publications: 1. Basu S, Nair N., Awasare S., Tiwari BP, Asopa R, Nair C. 2004 Apr; “99mTc (V) DMSA Scintigraphy In Skeletal Metastases and Superscans Arising From Various Malignancies: Diagnosis, Treatment Monitoring and Therapeutic Implications.” British Journal Radiology. 77(916):347-61. (if=1.938, ci=14) 2. Basu S., Nair N., Banavali S. (2007) Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: Potential clinical role of FDG-PET in the management British Journal of Radiology, 80(957), pp. 750-756. (if=1.938, ci=25) 3. Basu S., Chryssikos T., Houseni M., Malay Scot D, Shah J, Zhuang H, Alavi A. 2007 Jun “Potential Role of FDG-PET in the Setting of Diabetic Neuro-Osteoarthropathy: Can it Differentiate Uncomplicated Charcot Neuroarthropathy from Osteomyelitis and Soft Tissue Infection?” Nucl Med Commun.;28(6):465- 72. (if=1.379, ci=71) 4. Basu S, Zaidi H, Houseni M, Bural G, Udupa J, Acton P, Torigian D, Alavi A.. 2007 May Novel Quantitative Imaging Techniques for Assessing Regional and Global Function: Implications for Normal Variation, Aging, and Diseased States. Semin Nucl Med;37(3):223-39.(if=4.571, ci=60) 5. Basu S., Houseni M., Bural G, Chamroonat W, Udupa J, Mishra S, Alavi A.. 2007 Nov-Dec. Magnetic Resonance Imaging Based Bone Marrow Segmentation for Quantitative Calculation of Pure Red Marrow Metabolism Using 2-Deoxy-2-[F-18]fluoro-D: -glucose- Positron Emission Tomography: a Novel Application with Significant Implications for Combined Structure-Function Approach. (if=3.095, ci=17) 6. Basu S., Mallath MK, Peshwe H, Asopa R, Vyawahare M. 2008 . FDG-PET and PET/CT in the clinical management of Gastrointestinal Stromal Tumour (GIST). Nucl Med Commun; 29(12): 1026-39. (if=1.379, ci=32) 7. Basu S., Chen W, Tchou J, Mavi A., Cermik T., Czerniecki B, Schnall M and A. Alavi. 2008 Comparison of Triple Negative and ER+/PR+/HER 2- Breast Carcinomas Utilizing quantitative FDG-PET imaging parameters: A Potentially Useful Method for Disease Characterization. (if=5.201, ci=106) 8. Basu S, T Chryssikos, S Moghadam-Kia, H Zhuang, D Torigian, A Alavi. 2009 Jan PET as a Diagnostic Tool in Infection: Present Role and Future Possibilities. Semin Nucl Med; 39(1):36-51. (if=4.571, ci=126) 9. Basu S, Zhuang H, Torigian D, Rosenbaum J, Chen W, Alavi A. 2009 March Functional Imaging of Inflammatory Diseases of Unknown Etiology using Nuclear Medicine Techniques. Semin Nucl Med; 39(2): 124-145 (if=4.571, ci=93) 10. Basu S. 2010 Nov Personalized versus Evidence Based Medicine with PET Based Imaging. Nature Reviews Clinical Oncology; 7(11): 665-8. (if=15.031, ci=13)

409

CHAKRABORTY, SOUMEN (b 1969), Scientist, Institute of Life Sciences, Nalco Square, Bhubaneswar- 751023

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Chakraborty and his group, in active collaboration with the clinicians, works on the disease progression of chronic myeloid leukemia and the role of post translationally modified in leukemogenesis. His group reported that a combination therapy of Imatinib and JAK inhibitor killed CML progenitor's cells more efficiently than Imatinib alone. The lab also works on the proto-oncogene EVI1 which was reported to be involved in the initial phase of CML and is elevated with the progression of the disease. He has shown that EVI1 is periodically acetylated and deacetylated and this activity of EVI1 can divergently regulate various pathways by influencing Bcl-xL, SIRT1 and ΔNp63 which was reported by the lab for the first time as direct targets of EVI1. A set of EVI1 positive CML samples showed higher expression of Bcl-xL and SIRT1 with respect to EVI1 negative CML samples. Thus post-translationally modified form of EVI1 may protect the cells from apoptosis and thus can accumulate more mutations. Drastic changes in the localization pattern of EVI1 and SUMO1 was observed when EVI1 positive cells were treated with arsenic trioxide. This finding may someday pave a way to understand the significance of arsenic trioxide (Trisenox) that was used in a clinical trial to treat patients with myelodysplastic syndrome showing high expression of EVI1. Thus post translational modification data obtained so far has initiated a new paradigm of targeting modification dependent mechanisms working alone or in combination, on EVI1, that abnormally deregulates several biochemical pathways in advanced CML. Proposer: Dr. Samit Chattopadhyay, Seconder: Dr. Sharmila Bapat Ten Best Publications: 1. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G. 2001. Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localizatio (if=6.8, ci=76) 2. Chakraborty S, Sinha KK, Senyuk V, Nucifora G. 2003. SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. Oncogene. 22(34):5229-37. (if=8.0, ci=68) 3. Pradhan AK, Kuila N, Singh S, Chakraborty S. 2011. EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1. Biochim Biophys Acta-Gene Regulatory Mechanism. 1809 (4-6):269-75. (if=5.4 , ci=10) 4. Pradhan AK, Mohapatra AD, Nayak KB, Chakraborty S. 2011. Acetylation of the Proto-Oncogene EVI1 Abrogates Bcl-xL Promoter Binding and Induces Apoptosis. PLOS ONE. 6(9):e25370. (if=4.6, ci=15) 5. Pradhan AK, Kuila N, Singh S, Chakraborty S. 2011. EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1. Biochim Biophys Acta-Gene Regulatory Mechanism. 1809 (4-6):269-75. (if=5.4, ci=10) 6. Agatheeswaran S, Singh S, Biswas S, Biswas G, Chandra Pattnayak N, Chakraborty S. 2013. BCR- ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia. Leukemia. 27(7):1578-80. Jun 13; 1833(10):2357-23 (if=13, ci=12) 7. Singh S, Pradhan AK, Chakraborty S. 2013. SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic trioxide. Biochim Biophys Acta - Molecular Cell Research. (if=5.2, ci=3) 8. Agatheeswaran S, Chakraborty S. 2014 Response to “JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo”. [E-Letter] Blood (http://www.bloodjournal.org/content/124/9/1492.e-letters) (if=9.7) 9. Agatheeswaran S, Pattnayak NC, and Chakraborty S. 2016 Identification and functional characterization of the miRNA gene regulatory network in chronic myeloid leukemia lineage negative cells. Sci Rep. Sep 2;6:32493. (if=5.2) 10. Agatheeswaran S and Chakraborty S. MEF2C and CEBPA: possible coregulators in Chronic Myeloid Leukemia disease progression. 2016 Int J Biochem Cell Biol. Aug;77(Pt A):16570. (if=4.2)

410

CHATTOPADHYAY, KOUSHIK (b 1980) Researcher, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Koushik Chattopadhyay graduated with a Ph.D. in human genetics from University of Cape Town in South Africa. He worked on cancer molecular genetics during his Ph.D. He worked on neurogenetics arid pharmacogenetics for his first and second postdoctoral fellowships subsequently in South Africa. Following this he took up a faculty position at the Genetics department at University of KwaZulu-Natal in South Africa. After briefly serving as a lecturer he moved to the USA. Currently he is working on genetic epidemiology of cancer at University of Pittsburgh in the USA. He has 8 peer-reviewed first-author publications in international journals, 1 peer-reviewed conference publication and 2 e-books published. Currently 6 more first-author manuscripts are under-review. His publications have generated 63 citations till date. He is on the editorial board of 8 international journals 'and has also reviewed several articles for different international journals. He has presented his work in 8 international conferences as oral and poster presentalrt>ns including, American Society of Human ,Genetics Conference in 2012. He has won several fellowships ana awards including Poliomyelitis Research Foundation (PRF) Ph.D., fellowship. He has attended international workshops to improve his skills that include Advanced Molecular Methods for Diagnosfs of Human Genetic Diseases conducted by International Centre tor, Genetic Engineering and Biotechnology (ICGEB) in Iran and a genotyping training using TaqMan's Assay at Uppsala University in Sweden. From his career graph it is- evident that he is a promising scientist and had significant contribution in the field' of human genetics and cancer biology. Proposer : Dr. Gopal C. Kundu, Seconder : Dr. Vijay Kumar Ten Best Publications : 1. Chatterjee K, Engelmark M, Gyllensten U, van der Merwe L, Galal U, Hoffman M. Dandara C and Williamson AL, 2009, Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans, BMC Research Notes, Nov 26;2:238. Impact factor of the Journal: 1.39, Citation Index of the Paper: 17. 2. Chatterjee K, 2010, Host genetic factors in susceptibility to HIV-1 infection and progression to AIDS. Journal of Genetics, Apr 89(1 ):109-16. Impact factorof the Journal: 0.876, Citation Index of the Paper: 11. 3. Chatterjee K, Dandara C and Williamson AL. 2010, CCR2-V641 polymorphism is . associated with decreased risk of cervical cancer but not with HPV infection or pre­ cancerous lesions in African women, BMC Cancer. June 10:10(1):278. Impact factor of the Joumal: 3.33, Citation Index of the Paper: 11. 4. Chatterjee K, Gyllensten U, van der Merwe L, Galal U, Hoffman M, Dandara C and Williamson AL. 2010, A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women, Journal of Medical Virology, Dec;82(12)2082-6. Impact factor of the Journal: 2.373, Citation Index of the Paper: 6. 5. Chatterjee K. Williamson AL. Hoffman M and Dapdara C, 2011, CASP8 promoter polymorphism is associated with high risk HPV types and abnormal cytology but not with cervical cancer, Journal of Medical'Virology, Apr;83(4):630-6. Impact factor of the Journal: 2.373, Citation Index of the Paper: 6. 6. Chattopadhyay K, 2011, A comprehensive review on host genetic susceptibility to HPV infection anq progression to cervical cascer, Indian Journal of Human Genetics, Sep;1~(3):132-44. Impact factor of the Journal: N/A, Citation Index of the Paper: 9. 7. Chattopadhyay K, 2012, The genetic factors influencing the development of Trichotillomania, Journal of Genetics, Aug;91 (2):259-62. Impact factor of the Journal: 0.876, Citation Index of the Paper: 3. 8. Chattopadhyay K and Kar B, 2012, An investigation of Ph 1 chromosome in Chronic Myeloid ueukaernia patients with different treatment modalities and haematological features, Indian Journal of Human Genetics, Sep;18(2):229-32. Impact factor of the Journal: N/A, Citation Index of the Paper: N/A. (NOTE: Previously my surname was "Chatterjee")

411

CHAUDHURI, SWAPNA (b 1954), Emeritus Medical Scientist, ICMR, Dept of Laboratory Medicine, School of Tropical Medicine, Kolkata

Member of the NASI: No (YON 2014 , Medical & Forensic Sciences)

Prof. Chaudhuri’s research team first evidenced the disease relevance of the biomolecule T11TS, isolated from sheep RBC which was characterized in her lab. The molecule showed multimodal mechanistic activities for glioma abrogation in animal model. It showed intense immune potentiation both in the peripheral and intracranial systems; leading to glioma specific cell apoptosis, sparing normal cells; inhibition of the glioma cell cycle though intracranial immune cells showed survival and proliferation. The immune synapse and downstream signaling of glioma induced anergic lymphocytes were rejuvenated; lastly, it also retarded neo-angiogenesis in the glioma, hindering glioma growth, and also preventing invasion and metastasis. Acute and sub acute Toxicological studies with T11TS proved it to be totally non-toxic.T11TS also showed its efficacy on in vitro human glioma samples.T11TS acting in such multimodal fashion can be denoted as an ideal Anti-Cancer agent. Studies on arsenic-induced carcinogenesis in mouse models showed that T11TS was able to revert to the immune state from carcinogenic to normal state (17). Steps are being taken to clone T11TS and revealing the functions of the cloned product T11TS will pave the way for the therapeutic intervention and a large scale product development for the treatment of cancer. The above components will be tested for their anti tumor activity in vitro and in vivo using the most translatable animal model (primary tumor xenografts). This novel molecule on translation can act as a remedy for various types of cancer and other immunosuppressive diseases. Proposer : Dr. Syamal Roy, Seconder : Dr. Sekhar Chakrabarti Ten Best Publications: 1. Singh M K, Chaudhuri S, Bhattacharya D, Kumar P,Dutta, A and Chaudhuri Swapna (2015). T11Target Structure induced modulations of the pro-inflammatory and anti -inflammatory cytokine expressions in experimental animals for glioma abrogation. Int Immunopharmacol. 24 ,198-207 (if=2.711 , ci=No citation yet) 2. Chaudhuri Suhnrita, Singh MK, Bhattacharya D, Acharya S, Chatterjee S, Kumar P, Bhattacharjee P, Basu AK, Sa G, Das T, Ghosh TK and Chaudhuri Swapna (2014) . The novel immunotherapeutic molecule T11TS moduates glioma-induced changes of key components of the immunological synapse in favor of T-cell activation and glioma abrogation. J Neuro Oncol . 120( 1), 19-31 (if=2.787 , ci=No citation yet) 3. Bhattacharya D, Singh M K, Chaudhuri S, Acharya S, Basu A K and Chaudhuri Swapna (2013). T11TS impedes glioma angiogenesis by inhibiting VEGF signaling and pro-survival PI3K/Akt/eNOS pathway with concomitant upregulation of PTEN in brain endothelial cells. J Neurooncol, 113 (1): 13-25. (if=2 .787 , ci=6) 4. Ghosh A and Chaudhuri Swapna (2010). Microglial action in glioma: A boon turns bane. Immunology Letters.131: 3–9. (if=2.367 , ci=29) 5. Bhattacharjee M, Acharya S, Ghosh A, Sarkar P, Chatterjee S, Kumar P and Chaudhuri Swapna (2008). Bax and Bid act in synergy to bring about T11TS mediated glioma apoptosis via the release of mitochondrial Cytochrome c and subsequent caspase activation. Int Immunol, 2 (12): 1489–1505 (if=3.1 81 , ci=22) 6. Mukherjee J, Ghosh A, Sarkar S, Mazumdar M, Sarkar P, Duttagupta A K and Chaudhuri Swapna (2005).T11TS/SLFA-3 induces apoptosis of the brain tumor cells: A new approach to characterize the apoptosis associated genetic changes by arbitarily primed-PCR. Can Lett, 222: 23-38. (if= 5.016 , ci=8) 7. Mukherjee J, Sarkar S, Ghosh A, Duttagupta A K, Chaudhuri S and Chaudhuri Swapna (2004). Immunotherapeutic effects of T11TS/SLFA-3 against nitrosocompound mediated neural genotoxicity. Tox Lett, 150: 239-257. (if= 3.355 , ci=25) 8. Sarkar S, Ghosh A, Mukherjee J, Chaudhuri S and Chaudhuri Swapna (2004). CD2-SLFA-3/T11TS interaction facilitates immune activation and glioma regression by T11TS, Canc Biol Ther, 3(11): 1121- 1128. (if= 3.63 , ci=12) 9. Sarkar S, Begum Z, Dutta S, Chaudhuri S and Chaudhuri Swapna (2002). Sheep form of Leucocyte Function Antigen 3 (T IITS) exerts immunostimulatory and anti-tumor activity against experimental brain tumor: A new approach to biological response modifier therapy. J Exp Clin Cancer Res, 21(1), 95-106 (if= 3.27 , ci=26) 10. Chaudhuri S, Chaudhuri Swapna, Barfoot R, Denham S and Hall J G (1993). The stimulation by Dendritic cells of Host versus graft reactivity in vivo. Immunol Cell Biol, 71, 527 533 (if= 4.405 , ci= 4)

412

CHOUDHURY, NABAJYOTI (b 1959), Additional Director & Head; Fortis Memorial Research Institute, Gurgaon

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Nabajyoti Choudhury is one of the prominent transfusion medicine specialists in India. After completing his post-graduation from PGIMER, Chandigarh, he was a founder faculty to start MD in Transfusion Medicine in 1990 at SGPGIMS, Lucknow for the first time in the country. He started DNB in Transfusion Medicine for the first time in India. He started four state of the blood banks in the country and taking to the highest level, i.e. SGPGI, Lucknow; Prathama Blood Centre, Ahmedbad; Tata Medical Centre, Kolkata and Blood Bank in Fortis hospital, Gurgaon. He has 73 publications out of which, 58 are in indexed journals. He has also published 11 chapters in various text books and monographs. He was the founder Editor of Asian Journal of Transfusion Science which was the first journal in transfusion Medicine to receive PubMed accreditation in shortest possible time i.e. three years. He was also the founder Chairperson of the Technical Committee of NABH who was instrumental in writing NABH Standard, initiating and implementing NABH (Blood Bank) accreditation program across India. He has got Fortis (Gurgaon) blood bank accredited by NABH within record possible time i.e. six months after becoming operational. He is the Secretary General of Asian Association of Transfusion Medicine (AATM) which is transnational organization. He is a member of Expert Advisory Body of WHO-Geneva for South Asia. On behalf of United Nations, he has worked in multiple countries like Indonesia, Maldives, Timor-Leste, Netherlands etc. He is instrumental in developing linkage in developing blood transfusion services in South Asian countries through AATM. It is strongly recommended that he should be considered as Fellow of NASI. Proposer: Dr. Rakesh Kumar Gupta, Seconder: Prof. Rakesh Aggarwal

Ten Best Publications: 1. CHOUDHURY N, Jolly JG, Mahajan RC, Dubey ML, Kalra A, Ganguly NK. 1988. Selection of blood donors in malaria endemic countries. Lancet II: 971-2. (if=Very High) 2. CHOUDHURY N, Jolly JG, Mahajan RC, Dubey ML, Kalra A, Ganguly NK. 1990. Post transfusion malaria in thalassaemia patients. Blut 61: 314-6 (if=Very high) 3. CHOUDHURY N, Ramesh V, Saraswat S, Naik S. 1995. Effectiveness of mandatory screening tests in Indian blood donors. Indian J Med Res 64:541-4. (if=Medium) 4. CHOUDHURY N, Singh P, Chandra H. 1995. AIDS awareness in North Indian Blood donors. Transf Med 5: 269-73 (if=High) 5. CHOUDHURY N, Saraswat S, Neveed M. 1998. Serological monitoring of thalassaemia major patients for transfusion associated viral infections. Indian J Med Res 107: 263-268 (if=Medium) 6. CHOUDHURY N, Ayagiri A, Ray VL. 2000. True HIV seroprevalence in Indian blood donors. Transfusion Med. 10: 1-4. (if=High) 7. CHOUDHURY N. Transfusion Medicine in year 2025: Facts or fantasy? 2007. Asian J Transfusion Science. 2 (1); 1-2. (if=Low (indexed)) 8. CHOUDHURY N. Can there be blood units of high and low quality? 2009. Asian J Transfusion Science. 3 (1); 1-2 (if=Low (indexed)) 9. CHOUDHURY N. Transfusion transmitted infections: how many more? 2010. Asian J Transfusion Science. 2010: 4 (2); 72-73 (if=Low (indexed)) 10. CHOUDHURY N, Tulsiani Sunita, Desai Priti, Shah Ripal, Mathur Ankit, Harimurthy V. 2011. Serial follow-up of repeat voluntary blood donors reactive for anti HCV ELISA. Asian J Transfusion Science. 5(1); 26-31 (if=Low (indexed))

413

GANGENAHALLI, GURUDUTTA UGRAIAH (b 1960), Scientist G & Addl. Director, Institute of Nuclear Medicine & Allied Sciences, Head, Division of Stem Cell Research, DRDO, Ministry of Defence, Delhi- 110054

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Gurudutta Gangenahalli, FICS, FNABSc, FICI, FRAM, FRSB, FRSM, FRSC, who is presently Scientist G & Addl. Director, INMAS has carried out research on understanding the stem-cell fate- mechanisms and develop their fate-modifying molecules which enhance their regenerative potentials & particularly for injury treatment of Defense interest. His first-time hBCL-2 active-site discovery enabled hBCL-2 molecular generation having enhanced shelf-life and cell-survival, and anti-cancer molecules. The first-time elucidation of negative-control of c-Kit/tyrosine-kinase (SCF-receptor) by SHP1(Phosphatase) and signal-cluster enabled to develop a molecule to drive hHSC-proliferation. The mapping of transcription-factor(hPU.1) binding to GATA-1(Erythroid-Transcription-factor) causing negative-regulation, including MA-gene-expression effected by engineered-PU1(Y244A) lead the development of Nano-formulation which promotes preferential hu-HSC-differentiation to myeloid-lineage (Patented). He also elucidated the signaling-domain in hCD34-antigen (sole hHSC marker) and in hCXCR4 that enhances stem-cell trans-endothelial migration. His efforts to decipher the mechanism of osteogenesis, lead to first-time discovery of RRAD as hu-Osteogenic signaling-target in huMSCs & usefulness of Lithium in priming MSCs and potential osteogenic-therapy. Similarly, the identification of hypo-immune response gene-clusters in hMSCs has helped to manipulate their clinical-potential. The microencapsulation technology (Biomaterials & Poloxamer based) developed by him found to reduce huge stem-cell number requirement/recipient in pre-clinical models by specific bone-marrow targeting, forming a new revolutionary-innovation in clinical-transplantation. The in-vivo SC tracking by NMR (7- 9Tesla) is another innovative development to his credit. The developing hu-Low-Density-Lipoprotein (hLDL) as receptor-probe having a potential for clinical inflammation & atherosclerotic lesion imaging is a novel-method. His work on establishing conditions for hMSCs cultivation in abundance is extensively followed & cited. Proposer: Dr.V.K.Kashyap , Seconder: Prof. Jitendra P. Khurana Ten Best Publications: 1. Sushant Mishra, Subash Kushu and GURUDUTTA Gangenahalli*. 2016. Therapeutic Prospective of Infused Allogenic Cultured MSCs in Traumatic Brain Injury Mice: A longitudinal 1H MRS assessment. Stem Cells (Translational Medicine) (Alpha Med, USA). 5, 1-14 (if=5.7 (*Corres Author), ci=2 (Recent Best Published Paper)) 2. G.U. GURUDUTTA*, Shilpa Sharma, Farhat Afrin, Pallavi Gupta, Yogesh Kumar Verma, Vimal Kishor Singh, R.P.Tripathi. Mesenchymal stem cells: molecular targets for tissue engineering. Neeraj Kumar Satija, 2007. Stem Cells & Development (Mary Ann Liebert (if=4.67 (*Corres Author), ci=185) 3. Menka Sharma, Farhat Afrin, NeerajSatija, R P Tripathi, G.U. Gurudutta* et al. 2011. SDF-1/CXCR4 signaling in homing and engraftment of bone marrow hematopoietic stem cells. Stem Cell & Development (Mary Ann Liebert, USA). 1-12. 6. 20. (if=4.67 (*Corres Author), ci=90) 4. Neeraj Kumar Satija, Farhat Afrin, R PTripathi, GURUDUTTA Gangenahalli*. 2013. High-throughput transcriptome profiling of bone ma GS3βKinase inhibition as their priming target to stimulate the differentiation towards osteoblastic rrow derived human M (if=4.8 (*Corres Author), ci=26) 5. G.U. Gurudutta*, Vimalkishor singh, YogeshVerma, Pallavi Gupta, Ramesh Chandra, Shweta Gulati, and Pratibha Mehta Luthra. 2006. Hematopoietic stem cell antigen CD34: role in adhesion or homing. Stem cells and Development (Mary Ann Liebert, USA). 15 ( (if=4.67 (*Corres Author), ci=82) 6. GURUDUTTA Gangenahalli*, Yogesh Kr Verma, Vimal Kishor Singh, Pallavi Gupta, H.G. Raj, R.K. Sharma, Ramesh Chandra. 2005. Structural conservation of residues in BH1 and BH2 domains of Bcl-2 family proteins. FEBS Letters. 579(17), 3503-3507. (if=3.61 (*Corres Author), ci=22) 7. Yogesh Kumar verma, Pawan Kumar, Raghav, H G Raj, Gurudutta Gangenahalli*. 2013. Enhanced hetero-dimerization of Bax by Bcl-2 mutants improves irradiated hematopoietic cell survival. Apoptosis (Springer) (USA). 18. 212–225. (if=4.78 (*Corres Author), ci=12) 8. Yogesh Kr Verma, Gangenahalli U. GURUDUTTA*, Vimal Kishor Singh, Pallavi Gupta, H.G. Raj, R.K. Sharma, Ramesh Chandra. 2006. Cell death regulation by B-cell lymphoma protein. Apoptosis (USA) 11 (5), 459-471. (if=4.78 (*Corres Author), ci=37) 9. Potential stem cell labeling ability of poly-L-lysine complexed to ultrasmall iron oxide contrast agent: An optimization and relaxometry study. Sushant Mishra, Subash Kushu and Gurudutta Gangenahalli* 2015. (Experimental Cell Research (Elsevier), 339 (if=3.24 (*Corres Author), ci=4 (Recent Paper)) 10. G.U.GURUDUTTA*, A.K.Babbar, Soumya Pati, R.K.Sharma. 2001. Evaluation of potential tracer ability of 99mTc-labelled acetylated LDL for scintigraphy of LDL scavenger receptor sites of macrophageal origin. Nuclear Medicine and Biology (Elsevier, USA) 3 (if=3.01(*Corres Author), ci=11)

414

GARG, RAVINDRA KUMAR (b 1960), Professor and Head, Department of Neurology, King George Medical University, Lucknow

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

In last 25 years, Dr RK Garg has published more than 370 publications. His areas of interest include CNS infections like CNS tuberculosis, neurocysticercosis, SSPE and leprosy. Neurocysticercosis is the most common parasitic disease of the CNS. Solitary cysticercus granuloma is a common cause of focal seizures. Controversy exists regarding the efficacy of various modalities of treatment. In follow-up studies he confirmed that the most important feature of these solitary enhancing lesions is spontaneous disappearance, within weeks or months. Some lesions "heal" by becoming calcified. These patients require only antiepileptic drugs, and this medication may be withdrawn safely after the lesion has resolved. In two open-label studies and in one placebo controlled study he suggested the effectiveness of oral corticosteroids for controlling seizures and disabling headache in patients with solitary cysticercus granuloma. In one study, he observed that oral corticosteroids were helpful in early resolution of the lesion. He observed that infective pathologies were the most common etiology for multiple enhancing lesions of the brain. Tuberculosis was the commonest infective pathology, followed by neurocysticercosis. He highlighted the fact that, in India, often it is difficult to differentiate between tuberculoma and a cysticercal granuloma. He suggested diagnostic criteria for this differentiation. Another important area he is presently working is tuberculous meningitis. He is trying to know the pathogenesis, predictors and prognostic impact of several major complications, like vision loss, stroke, tuberculomas and arachnoiditis, of tuberculous meningitis. Proposer : Prof. Rashmi Kumar, Seconder : Prof. Rakesh Kumar Gupta Ten Best Publications: 1. Garg RK. Posterior leukoencephalopathy syndrome. Postgrad Med J 2001;77(903):24-8. (if=1.608, ci=272) 2. Garg RK. Tuberculosis of the central nervous system. Postgrad Med J 1999;75(881):133-40. (if=1.608, ci=217) 3. Garg RK. Acute disseminated encephalomyelitis. Postgrad Med J 2003;79(927):11-7. (if=1.608, ci=210) 4. Garg RK. Subacute sclerosing panencephalitis. Postgrad Med J 2002;78(916):63-70. (if=1.608, ci=178) 5. Garg RK, Potluri N, Kar AM, Singh MK, Shukla R, Agrawal A, Verma R. Short course of prednisolone in patients with solitary cysticercus granuloma: a double blind placebo controlled study. J Infect 2006;53(1):65-9. (if=4.073, ci=30) 6. Garg RK, Karak B, Mohan Kar A. Neuroimaging abnormalities in Indian patients with uncontrolled partial seizures. Seizure 1998 Dec;7(6):497-500. (if=2.004, ci=17) 7. Sinha MK, Garg RK, Anuradha HK, Agarwal A, Singh MK, Verma R, Shukla R. Vision impairment in tuberculous meningitis: predictors and prognosis. J Neurol Sci 2010;290(1-2):27-32. (if=2.243, ci=19) 8. Garg RK, Desai P, Kar M, Kar AM. Multiple ring enhancing brain lesions on computed tomography: an Indian perspective. J Neurol Sci 2008 Mar 15;266(1-2):92-6. (if=2.243, ci=13) 9. Raut T, Garg RK, Jain A, Verma R, Singh MK, Malhotra HS, Kohli N, Parihar A. Hydrocephalus in tuberculous meningitis: Incidence, its predictive factors and impact on the prognosis. J Infect 2013;66:330-7. (if=4.073, ci=15) 10. Singh B, Garg RK, Singh MK, Verma R, Malhotra HS, Jain A, Singh R, Kohli N, Phadke RV, Shukla R, Parihar A. Computed tomography angiography in patients with tuberculous meningitis. J Infect 2012;64:565-72. (if=4.073, ci=10)

415

JULKA, PRAMOD KUMAR (b 1950), Dean (Academics) and Professor, All India Institute of Medical Sciences, New Delhi

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

With over three decades of research in cancer and major breakthroughs in the treatment procedures and protocols, Dr. P.K. Julka indisputably stands as a pioneer oncologist in India. He has performed India’s first Peripheral blood stem cell transplant following high dose chemotherapy in Metastatic Breast Cancer with the aim to improve the overall survival that has made a significant scientific contribution to the clinical practice of oncology in India (Limca Book of Records). He has developed several investigator initiated research protocols in order to find newer indications for the existing drugs as well as newer therapies for the treatment of various cancers. His seminal contributions include: establishing the role of gemcitabine and carboplatin chemotherapy in the treatment of gallbladder cancer where no other standard therapy existed; prediction of response with sequential gemcitabine based combinations in patients with operable breast cancer using molecular profiling with Agilent human microarrays covering over 17,000 genes; establishing the role of tamoxifen for 10 years instead of 5 years in women with ER positive breast cancer; establishing the role of adjuvant Trastuzumab in HER-2 positive breast cancer; postoperative treatment of glioblastoma multiforme with radiation therapy plus concomitant and adjuvant temozolomide etc. His work has benefited eminent researchers across the globe and has been instrumental in changing the clinical practice worldwide. He is also the author of the first book from India on ‘Developing A World Class Clinical Trial Site’ that provides a step by step guide to the clinicians for becoming a successful clinical researcher. Proposer : Prof. N. R. Jagannathan, Seconder : Prof. T. P. Singh Ten Best Publications:

1. Butts C, Socinski MA, Mitchell PL, Thatcher N, Havel L, Krzakowski M, Nawrocki S, Ciuleanu TE, Bosquée L, Trigo JM, Spira A, Tremblay L, Nyman J, Ramlau R, Wickart-Johansson G, Ellis P, Gladkov O, Pereira JR, Eberhardt WE, Helwig C, Schröder A, Shepherd FA; START trial team. 2014 Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial. Lancet Oncol.15 (1):59-68. (if=25.117, ci=no citation as yet) 2. Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, Abraham M, Medeiros Alencar VH, Badran A, Bonfill X, Bradbury J, Clarke M, Collins R, Davis SR, Delmestri A, Forbes JF, Haddad P, Hou MF, Inbar M, Khaled H, Kielanowska J, Kwan WH, Mathew BS, Mittra I, Müller B, Nicolucci A, Peralta O, Pernas F, Petruzelka L, Pienkowski T, Radhika R, Rajan B, Rubach MT, Tort S, Urrútia G, Valentini M, Wang Y, Peto R; Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. 2013 Long- term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 381(9869):805-16. Erratum in: Lancet. 2013 Mar 9; 381(9869):804. (if=39.060, ci=16) 3. Julka PK, Chacko RT, Nag S, Parshad R, Nair A, Koppiker CB, Xue FC, Barraclough H, Dhindsa N, Seth A, Majumdar A, Puri T. 2013 A phase 2 study of sequential neoadjuvant chemotherapy with gemcitabine and doxorubicin followed by gemcitabine and cisplatin in patients with large or locally advanced operable breast cancer: results from long-term follow-up. Breast Cancer. 20(4):357- 62.(if=1.330, ci=no citation as yet) 4. Slamon D, Eiermann W, Robert N, Pienkowski T, Martin M, Press M, Mackey J, Glaspy J, Chan A, Pawlicki M, Pinter T, Valero V, Liu MC, Sauter G, von Minckwitz G, Visco F, Bee V, Buyse M, Bendahmane B, Tabah-Fisch I, Lindsay MA, Riva A, Crown J; Breast Cancer International Research Group. 2011 Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med. 365(14):1273- 83.(if=51.658, ci=66) 5. Gregoire V, Hamoir M, Chen C, Kane M, Kawecki A, Julka PK, Wang HM, Prasad S, D'Cruz AK, Radosevic-Jelic L, Kumar RR, Korzeniowski S, Fijuth J, Machiels JP,Sellers MV, Tchakov I, Raben D. 2011 Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: A phase II, randomized, double-blind, placebo-controlled study. Radiother Oncol. 100(1):62- 9. (if=4.520, ci=3) 6. Digumarti R, Wang Y, Raman G, Doval DC, Advani SH, Julka PK, Parikh PM, Patil S, Nag S, Madhavan J, Bapna A, Ranade AA, Varadhachary A, Malik R. 2011 A randomized, double-blind, placebo- controlled, phase II study of oral talactoferrin in combination with carboplatin and paclitaxel in previously untreated locally advanced or metastatic non-small cell lung cancer. J Thorac Oncol. 6(6):1098- 103. (if=4.473, ci=no citation as yet) 7. Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Rüschoff J, Kang YK; ToGA Trial Investigators. 2010 Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2- positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomized controlled trial. Lancet. 376(9742):687-97. (if=39.060, ci=224) 8. Julka PK, Chacko RT, Nag S, Parshad R, Nair A, Oh DS, Hu Z, Koppiker CB, Nair S, Dawar R, Dhindsa N, Miller ID, Ma D, Lin B, Awasthy B, Perou CM. 2008 A phase II study of sequential neoadjuvant gemcitabine plus doxorubicin followed by gemcitabine plus cisplatin in patients with operable breast cancer: prediction of response using molecular profiling. Br J of Can. 98: 1327–1335. (if=5.082, ci=6) 9. Julka PK, Doval DC, Gupta S, Rath GK. 2008 Response assessment in solid tumors: a comparison of WHO, SWOG and RECIST guidelines. Br J of Radiol. 81: 444-449. (if=1.22, ci=4) 10. Jagannathan NR, Kumar M, Seenu V, Coshic O, Dwivedi SN, Julka PK, Srivastava A, Rath GK. 2001 Evaluation of total choline from in vivo volume localized proton MR spectrosocpy and its response to neoadjuvant chemotherapy in locally advanced breast cancer. Br J Cancer. 84(8): 1016-1022. (if=5.082, ci=35) 416

KAUR, GURCHARAN (b 1958), Professor, Guru Nanak Dev University, Amritsar

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Prof. Gurcharan Kaur has far-reaching contributions in ‘Neuroscience’ in the area of Healthy Brain Aging and has scientifically validated the Indian traditional practices of (i) Intermittent Fasting- Dietary Restriction (IF-DR) and (ii) Natural products from medicinal plants. Prof. Kaur’s laboratory presented the first ever pre-clinical evidence for Withania somnifera and Tinospora cordifolia extracts as potential agents with capability for neuronal differentiation, an attractive supplementary therapeutic approach for the treatment of brain cancers (Ref #6, 20, 23, 34, 35, 41, 46). Her detailed mechanistic study of potential interventions by natural products promise to offer a unique therapeutic strategy in amelioration of neuroinflammation and neurological disorders associated with obesity and sleep disorders (Ref. # 1, 4, 5, 8, 10, 16, 22, 29, 37). Lifelong calorie restriction/DR although is in practice for millennia as a powerful tool for healthy aging, yet only her pre-clinical experimental studies have scientifically validated such imaginative benefits of late onset short term IF-DR regimen. Employing robust experimental designs, her work focused on neurobehavior in relation to molecular mechanisms which now warrant clinical applications of this lifestyle intervention in human subjects. Experimentally, such practices prevented loss of cognitive functions and improved motor co-ordination by modulating Neuron and Glial plasticity (Ref. # 17, 36, 40, 43, 45, 48, 49, 52, 57). Her work also provided novel insights into the structural and functional basis of neuron-glia interactions in modulating adult brain plasticity under various physiological and pathological conditions (Ref. # 7, 9, 15, 30, 39, 50, 54, 55, 58, 68). Proposer: Dr KP Mohanakumar, Seconder: Prof. PK Seth Ten Best Publications: 1. Sandhu SK and Gurcharan Kaur (2002) Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes. Biogerontology 3(3): 161-173. (if=3.25, ci=108) 2. Gurcharan Kaur, Heera PK and Srivastava LK (2002) Neuroendocrine plasticity in GnRH release during rat estrous cycle: Correlation with molecular markers of synaptic remodeling. Brain Research 954: 21-31. (if=2.56, ci=38) 3. Singh P, Jain A and Gurcharan Kaur (2004) Impact of hypoglycemia and diabetes on CNS: Correlation of mitochondrial oxidative stress with DNA damage. Mol. Cell. Biochem. 260: 153-159. (if=2.61, ci=117) 4. Sharma S and Gurcharan Kaur (2005) Neuroprotective potential of dietary restriction against kainate- induced excitotoxicity in adult male Wistar rats. Brain Res. Bull. 67(6): 482-491. (if=2.57, ci= 50) 5. Parkash J and Gurcharan Kaur (2005) Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule. J Endocrinology 186(2): 397-409. (if=4.49, ci= 46) 6. Shah N, Kataria H, Kaul SC, Gurcharan Kaur and Wadhwa R (2009) Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration and differentiation of glioblastoma cells: a combinational approach for enhanced diffe (if=3.89, ci= 47) 7. Kataria H., Wadhwa R., Kaul SC and Gurcharan Kaur (2012) Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PloS One. 7(5):e37080. (if=3.23, ci=35) 8. Singh R., Lakhanpal D, Kumar S, Sharma S, Kataria H, Kaur M and Gurcharan Kaur (2012) Late onset intermittent fasting dietary restriction as a potential intervention to retard age associated brain function impairments in male rats. AGE, 34(4): 917-93 (if=2.5, ci=44) 9. Hardeep Kataria, , Harshita Chaudhary and Gurcharan Kaur (2016) Withania somnifera suppresses tumor growth of intracranial allograft of glioma cells. Mol Neurobiol. 53(6): 4143-4158. (if=5.40, ci=5) 10. Rachana Mishra, Shaffi Manchanda, Muskan Gupta, Taranjeet Kaur, Vedangana Saini, Anuradha Sharma and Gurcharan Kaur (2016) Tinospora cordifolia ameliorates anxiety-like behavior and improves cognitive functions in acute sleep deprived rats Scientific (if=5.23, ci=1)

417

KHULLAR, MADHU (b 1953), Professor, Department of Experimental Medicine & Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

I have known Prof Madhu Khullar, first as a young faculty member later blossoming into a mature, internationally known research worker, an excellent teacher and an efficient group leader. She has made significant contributions in the field of cardiovascular diseases (genetics and pharmacogenomics of coronary heart disease, genetics of Idiopathic cardiomyopathy, genetics of Diabetic nephropathy, epigenetics of diabetic cardiomyopathy and dilated cardiomyopathy, Hypertension and environmental basis of head and neck cancer. Her current research projects include next generation sequencing as diagnostic tool for idiopathic cardiomyopathies. She has published nearly 160 papers in high impact factor journals including co-authoring in Nature Genetics. She has authored 2 books, monographs and contributed chapters in books which have been appreciated nationally and internationally. High quality research has been possible because of well-deserved funding from different National (ICMR, DBT, DST, CSIR) and International (NIH) agencies. Dr. Khullar is viewed as a leader in her subject area and is sought after speaker at National and International meetings on heart research. She has great organizational ability and is credited with organizing several International and National meetings on Cardiovascular Research at PGIMER, Chandigarh. She is also heading Cardiomyopathy Research Group at PGI. On a personal note, I find in her a sincere and hardworking researcher with leadership qualities and a good team worker with necessary intellectual potential of handling scientific matters. Proposer: Prof. C.C. Kartha, Seconder: Prof. Y.K. Gupta Ten Best Publications: 1. Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R (2000). Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. J Hypertens. Jul; 18(7):919-26. (if=4.72, ci=48) 2. Kumar R, Bandyopadhyay S, Aggarwal AK, Khullar M (2004). Relation between birthweight and blood pressure among 7–8 year old rural children in India. Int J Epidemiol. Feb; 33(1):87-91 (if=9.17, ci=14) 3. Khullar M, Sharma SK, Singh SK, Bajwa P, Shiekh FA, Relan V, Sharma M (2004). Morphological and immunological characteristics of nanobacteria from human renal stones of a north Indian population. Urol Res. Jun; 32(3):190-5. (if=1.17, ci=88) 4. Markan S, Sachdeva M, Sehrawat BS, Kumari S, Jain S, Khullar M (2007). MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem. Aug; 302(1-2):125-31 (if=2.3, ci=65) 5. Poduri A, Kaur J, Thakur JS, Kumari S, Jain S, Khullar M. (2008). Effect of ACE inhibitors and β- blockers on homocysteine levels in essential hypertension. J Hum Hypertens. Apr; 22(4):289-94 (if=2.7, ci=26) 6. Ahluwalia TS, Ahuja M, Rai TS, Kohli HS, Bhansali A, Sud K, Khullar M. (2009). ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy. DNA Cell Biol. Mar; 28(3):141-50. (if=2.1, ci=57) 7. Ahluwalia TS, Khullar M, Ahuja M, Kohli HS, Bhansali A, Mohan V, Venkatesan R, Rai TS, Sud K, Singal PK. (2009). Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians. PLoS One.; 4(4):e5168. (if=4.31, ci=60) 8. Dhandapany PS, Sadayappan S, Xue Y, Powell GT, Rani DS, Nallari P, Rai TS, Khullar M, Soares P, Bahl A, Tharkan JM, Vaideeswar P, Rathinavel A, Narasimhan C, Ayapati DR, Ayub Q, Mehdi SQ, Oppenheimer S, Richards MB, Price AL, Patterson N, Reich D, Singh L, Tyler-Smith C, Thangaraj K. (2009).A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nat Genet. 2009; 41(2):187-91. (if=29.35, ci=156) 9. Poduri A, Khullar M, Bahl A, Sehrawat BS, Sharma Y, Talwar KK. (2010). Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy. DNA Cell Biol. 29(10):629-37. (if=2.1, ci=30) 10. Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, Nishizawa T, Nakanishi T, Robbins J, Limongelli G, Hajjar RJ, Lebeche D, Bahl A, Khullar M, Rathinavel A, Sadler KC, Tartaglia M, Matsuoka R, Thangaraj K, Gelb BD. (2014). RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 46(6):635-9. (if=29.35, ci=14)

418

KUMAR, ASHOK (b 1960), Professor & Head, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Prof Ashok Kumar has made significant contributions towards understanding maternal-fetal iron homeostasis in maternal iron deficiency anemia. Until recently it was believed that fetus behaves as a complete parasite as far as its iron needs are concerned, and is capable of extracting iron from maternal circulation efficiently regardless of maternal iron levels. His work has shown that extraction of iron by fetus is a function of iron levels available in maternal circulation and fetal iron status and fetal growth are adversely affected in severe maternal iron deficiency anemia. Further, they have also shown that anemic women have insufficient iron present in their breast milk. Thus the offspring of an anemic mother is exposed to inadequate iron not only in-utero but also after birth. In addition to hemoglobin synthesis, iron is required for myelination of developing brain. Iron deficiency during this critical period of life may have long-term adverse effects on cognitive development. Another area where he has made significant contribution is his work on oxidative injury in perinatal asphyxia and anti-oxidant role of bilirubin in neonates. Recently his work on the genetics of neonatal jaundice has improved our understanding of this complex disorder. His work has shown that many cases of idiopathic hyperbilirubinemia in neonates are in fact due to the presence of polymorphisms of UGT1A1 and Heme oxygenase-1 genes. Proposer : Prof. Shyam Sundar, Seconder : Prof. Arvind Mohan Kayastha Ten Best Publications: 1. Singla PN, Tyagi M, Shankar R, Dash D, Kumar A. Fetal iron status in maternal anemia. Acta Paediatr 1996; 85: 1327-1330.(if=1.947, ci=(as per Google Scholar) 82) 2. Singla PN, Tyagi M, Kumar A, Dash D, Shankar R. Fetal growth in maternal anemia. J Trop Pediatr 1997; 43:89-92. (if=0.857, ci=95) 3. Kumar A, Rai A.K. Basu S., Dash D, Singh J.S. Cord blood and breast milk iron status in maternal anemia. Pediatrics 2008; 121: e673-677 (if=5.119, ci=58) 4. Kumar A, Mittal R, Khanna HD, Basu S. Free radical injury and blood brain barrier permeability in hypoxic ischemic encephalopathy. Pediatrics 2008; 122: e722-e727 (if=5.119, ci=63) 5. Kumar A, Ramakrishna SVK, Basu S, Rao GRK. Oxidative stress in perinatal asphyxia. Pediatric Neurology 2008; 38: 181-185.(if=1.416 , ci=26) 6. Kumar A, Pant P, Basu S, Rao GRK, Khanna HD. Oxidative stress in neonatal hyperbilirubinemia. Journal of Tropical Pediatrics 2007; 53:69-71. (if=0.857, ci=38) 7. Singh VV, Chauhan SK, Rai R, Kumar A, Singh SM, Rai G. Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.PLoS ONE 2013; 8: e62845 (if=3.370, ci=3) 8. Sukla KK, Tiwari PK, Kumar A, Raman R. Low birth weight (LBW) and neonatal hyperbilirubinemia (NNH) in an Indian cohort: Association of homocysteine, its metabolic pathway genes and micronutrients as risk factors. PLoS ONE 2013; 8:e 71587. (if=3.370, ci=7) 9. Tiwari PK, Sethi A, Basu S, Raman R, Kumar A. Heme oxygenase-1 gene variants and hyperbilirubinemia risk in north Indian newborns. European Journal of Pediatrics 2013;172(12):1627- 32. (if=1.901, ci=3) 10. 10 Tiwari PK, Bhutada A, Agarwal R, Basu S, Raman R, Kumar A. UGT1A1 gene variants and clinical risk factors modulate hyperbilirubinemia risk in newborns. Journal of Perinatology 2014;34(2):120-4 (if=2.248, ci=0)

419

MEHROTRA, RAVI (b 1956), Scientist G & Director, Institute of Cytology and Preventive Oncology (ICMR), Noida

Member of the NASI: (YON 2014, Medical & Forensic Sciences) Yes

Dr. Mehrotra’s work has focused on diagnostic and molecular changes in oral potentially malignant and malignant disorders, which are very pertinent and widespread health issues in India. He has published extensively on various diagnostic techniques in oral lesions. Given the exceptionally high use of tobacco, gutka and paan masala in this country, appropriate and easily available alternate sources of medical diagnostics are the need of the hour vis-à-vis complicated and expensive means available in more developed societies. He is one of the few investigators in the world researching the various changes at the cytological and molecular level and the prevalence of Human Papilloma viruses in oral lesions. As a Cytopathologist, he is considered one of the best in the country and diagnostically difficult cases are referred to him. His greatest contribution has been towards the development of superspeciality of Cytopathology in India. In his capacity as Director of Institute of Cytology and Preventiev Oncology (ICMR), he has the distinction of spearheading the long-awaited school of cytopathology. He is also responsible for starting ‘Health promotion Clinic’ at ICPO, Noida which mainly focuses on screening and early diagnosis of three major cancers namely, oral, breast and cervix in Noida and nearby places. He is the nodal person for formulating the uniform screening strategies in India and updating the guidelines on cancer. He has recently co-authored the recommendations for cancer screening strategies for the country (Lancet Oncology, 2015). Proposer : Prof. Chitra Sarkar, Seconder : Dr V.M.Katoch Ten Best Publications: 1. Rajaraman P, Anderson BO, Basu P, Belinson JL, D'Cruz A, Dhillon P, Gupta PC, Jawahar TS, Joshi N, Kailash U, Kapambwe S, Katoch VM, Krishnan S, Panda D, Sankaranarayanan R, Selvam JM, Shah KV, Shastri S, Shridhar K, Siddiqui M, Sudha S, Seth T, Srivastava A, Trimble T, Mehrotra R (2015) Recommendations for screening and early detection of common cancers in India. Lancet Oncol (In Press) (if= 24.229, ci= ) 2. Sinha R, Hussain S, Mehrotra R, Kumar RS, Kumar K, Pande P, Doval DC, Basir SF, Bhradwaj M.(2013) Kras Gene Mutation and RASSF1A, FHIT and MGMT Gene Promoter Hypermethylation: Indicators of Tumor Staging and Metastasis in Adenocarcinomatous Sporadic Colorectal Cancer in Indian Population. PLoS ONE 8(4):e60142 (if= 3.37, ci= 21) 3. Sharan RN, Mehrotra R, Chaudhary Y, Asotra K. (2012) Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective. PL0S ONE ;7(8): e42759 (if= 3.37, ci= 28) 4. Mehrotra R, DK Gupta. (2011) Exciting new advances in oral cancer diagnosis: avenues to early detection Head & Neck Oncology3:33 (if= 3.39, ci= 48) 5. Mehrotra R, Mishra S, Singh M, Singh M.(2011) The efficacy of oral brush biopsy with computerassisted analysis in identifying precancerous and cancerous lesions. Head Neck Oncol 3: 39 (if= 3.39, ci= 18) 6. Mehrotra R, Ibrahim R, Eckardt A, Driemel O, Singh M. (2011) Novel strategies in therapy of head and neck cancer. Curr Cancer Drug Targets 11;365-78 (if= 4.77, ci= 12) 7. AK Chaudhary, M Singh, AC Bharti, K Asotra, S Sundaram, Mehrotra R. (2010) Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck. J Biomed Sci. 15;17(1):10 (if= 2.09, ci= 50) 8. Chaudhary AK, Singh M, Sundaram S, Mehrotra R (2009) Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review. Head & Neck Oncology ;1:22 (if= 3.39, ci= 68) 9. Mehrotra R, Hullmann M, Smeets R, Reichert TE, Driemel O. (2009)Oral cytology revisited. J Oral Pathol Med. Feb;38(2):161-6. (if= 2.05, ci= 55) 10. Mehrotra R, Gupta A, Singh M, Ibrahim R. (2006) Application of cytology in diagnosing premalignant or malignant oral lesions. Mol Cancer 5:1 (if= 3.78, ci= 149)

420

MUKHOPADHYAY, SATINATH (b 1958), Professor, Department of Endocrinology, Institute of Post Graduate Medical Education & Research (IPGMER) and SSKM Hospital, Kolkata

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Professor Satinath Mukhopadhyay, has more than 20 years experience in patient care, teaching and translational research in the field of endocrinology, metabolism and diabetes. In addition to training post doc students in Endocrinology for their DM course, he also mentors PhD students working in the field of molecular endocrinology. He has so far guided four students to their PhD as a co supervisor and is currently supervising the work of around 12 research fellows. He has more than 80 original publications, more than 20 of them being in high impact journals like Nature Medicine, Journal of Biological Chemistry, Biochemical Journal, Metabolism, Lancet, Cellular Physiology and Biochemistry, Diabetes Research and Clinical Practice, Journal of Diabetes, Thyroid, etc. He has made significant contributions in the areas of lipid induced insulin resistance, Vitamin D deficiency in diabetes, Mitochondrial dysfunction in diabetes, thyroid disorders and ovarian cancer. He is actively involved in some of the major global clinical trials as a Principal Investigator (PI). Prof. Mukhopadhyay is a member of the American Endocrine Society, American Diabetes Association, International Osteoporosis foundation, European Association for the study of Diabetes, European society of endocrinology, European Neuroendocrine Association. He is in charge of the ‘Diabetic Foot Clinic’ at SSKM Hospital. Dr. Mukhopadhyay chairs the ‘committee on human ethics’ at CSIR-IICB, Kolkata. I have known Prof. Mukhopadhyay for the last several years as a medical scientist who is deeply involved in translational research. I strongly recommend his application for fellowship of the National Academy Sciences (India). Proposer : Dr. Hemanta K. Majumder, Seconder : Dr. Pijush Kanti Das Ten Best Publications: 1. Jani RH, Pai V, Jha P, Jariwala G, Mukhopadhyay S, Bhansali A, Joshi S. 2014 Feb, A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of Saroglitazar 2 and 4 mg compared with placebo in type 2 diabetes mellitus patients having hypertriglyceridemia not controlled with atorvastatin therapy (PRESS VI). Diabetes technology & Therapeutics. (if=2.205) 2. Basu M, Mukhopadhyay S, Chatterjee U, Roy SS. 2014 Jan, FGF16 promotes invasive behavior of SKOV-3 ovarian cancer cells through activation of mitogen-activated protein kinase (MAPK) signaling pathway. Journal of Biological Chemistry (if=4.651) 3. Dutta D, Mondal SA, Choudhuri S, Maisnam I, Hasanoor Reza AH, Bhattacharya B, Chowdhury S, Mukhopadhyay S. 2014 Jan 6. Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India. Diabetes Research and Clinical Practice. (if=2.741) 4. Meher D, Dutta D, Ghosh S, Mukhopadhyay P, Chowdhury S, Mukhopadhyay S. 2014 Jan 6. Effect of a mixed meal on plasma lipids, insulin resistance and systemic inflammation in non-obese Indian adults with normal glucose tolerance and treatment naïve type-2 diabetes. Diabetes Research and Clinical Practice. (if=2.741) 5. Chatterjee P, Seal S, Mukherjee S, Kundu R, Mukherjee S, Ray S, Mukhopadhyay S, Majumdar SS, Bhattacharya S. 2013 Sep 27. Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages. Journal of Biological Chemistry (if=4.651, ci=2) 6. Dutta D, Choudhuri S, Mondal SA, Maisnam I, Reza AH, Ghosh S, Chowdhury S, Bhattacharya B, Mukhopadhyay S. 2013 Mar. Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes. Diabetes Research and Clinical Practice. (if=2.741, ci=1) 7. Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S. 2012 Aug. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nature Medicine (if=22.864, ci=91) 8. Chattopadhyay M, Guhathakurta I, Behera P, Ranjan KR, Khanna M, Mukhopadhyay S, Chakrabarti S. 2011 Dec. Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus. Metabolism : Clinical and Experimental. (if=3.096, ci=5) 9. Dasgupta S, Bhattacharya S, Biswas A, Majumdar SS, Mukhopadhyay S, Ray S, Bhattacharya S. 2010 Aug. NF-kappaB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J. (if=4.654, ci=38) 10. Choudhuri S, Dutta D, Chowdhury IH, Mitra B, Sen A, Mandal LK, Mukhopadhyay S, Bhattacharya B. 2013 Jun. Association of hyperglycemia mediated increased advanced glycation and erythrocyte antioxidant enzyme activity in different stages of diabetic retinopathy. Diabetes Research and Clinical Practice. (if= 2.741)

421

PADHY, RABINDRA NATH (b 1954), Professor and Head, Central Research Laboratory, IMS & Sum Hospital, Bhubaneswar-03, Odisha, India

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Prof. Padhy has been working on development of antimicrobial drugs against drug-resistant pathogens, Gram-positive, Gram-negative bacteria, Mycobacterium tuberculosis and Mycobacterium leprae; and evaluation of cytotoxicity of drugs and phytochemical using isolated human lymphocytes and neural, carcinoma and hepatic cell lines. Using advance tools of bioinformatics for locating effective conjugated drugs (a pure phytochemical conjugated with an obsolete drug or antibiotic with an approach from medicinal chemistry) against human pathogens isolated from clinical samples of patients admitted to hospital. To control drug resistant bacteria though crude extracts of medicinal plants and cyanobacteria were attempted. Indeed, bioinformatics tools minimize time and resources for the development of suitable drugs before synthesis and isolation of pure phytochemicals. For example, phytochemicals are conjugated with obsolated mainstream sulfa drug, sulfamethoxazole for effectivity in controlling pathogenic drug-resistant bacteria. Similarly, the well known antimalarial drug, chloroquine conjugated with adhatodine from the plant Adhatoda vasica could be taken up by pharmacology for further development as a new drug against drug-resistant Plasmodium. Moreover, pure phytochemicals active against bacteria such as, epigallocatechin 3-gallate and eriodictyol were identified for further development of phytochemical-based mainstream medicine. In parallel, for in vitro evaluation of cytotoxicity and genotoxicity of developed drugs and phyto-extracts, along with non-target effects of pesticides causing harmful effects on health, using human umbilical blood (waste blood is collected from newly born babies in hospital). Proposer: Prof. P. Das, Seconder: Prof. G.R. Rout Ten Best Publications: 1. Swain SS, Paidesetty SK, Padhy RN (2017) Antibacterial activity, computational analysis and host toxicity study of thymol-sulfonamide conjugates. Biomed. Pharmacother. 88:181-193. (if=2.32, ci=Scopus, PubMed & Science Citation Index (Elsevier).) 2. Swain SS, Paidesetty SK, Padhy RN (2017) Development of antibacterial conjugates using sulfamethoxazole with monocyclic terpenes: A systematic medicinal chemistry based computational approach. Compt. Method. Program. Biomed. 140:185-194. (if=1.86, ci=Scopus, PubMed & Science Citation Index. (Elsevier).) 3. Patnaik R, Padhy RN (2017) Human umbilical cord blood-derived neural stem cell line as a screening model for toxicity. Neurotox. Res. doi. 10.1007/s12640-016-9681-x. (if=3.37, ci=Scopus, PubMed & Science Citation Index. (Springer).) 4. Rath S, Das SR, Padhy RN (2016) Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. Brazilian J. Otorhinolaryngology (if=0.73, ci=Scopus, PubMed. (Elsevier).) 5. Mishra MP, Sarangi R, Padhy RN (2016) Prevalence of multidrug resistant uropathogenic bacteria in pediatric patients of a tertiary care hospital in eastern India J. Infect. Pub. Heal. 9:308-314. (if=1.19, ci=Scopus, PubMed. (Elsevier).) 6. Patnaik R, Padhy RN (2016) Evaluation of geno-toxicity of methyl parathion and chlorpyrifos to human liver carcinoma cell line (HepG2) Env. Sci. and Pollut Res. 23(9):8492-8499. (if=2.76, ci=Scopus, PubMed & Science Citation Index (Springer).) 7. Swain SS, MC Sahu, RN Padhy (2015) In silico attempt for adduct agent(s) against malaria: combination of chloroquine with alkaloids of Adhatoda vasica. Comp. Method Program Biomed.122:16- 25. (if=1.86, ci=Scopus, PubMed & Science Citation Index (Elsevier).) 8. Swain SS, Padhy RN, Singh PK (2015) Anticancer compounds from cyanobacterium Lyngbya species ─ a review. Antonie v Leeuwen. J Microbiol.108 (2): 223-265. (if=1.94, ci=Scopus, PubMed & Science Citation Index (Springer).) 9. Rath SN, M Panda, MC Sahu, RN Padhy (2015) Bayesian analysis of two diagnostic methods for paediatric ringworm infections in a teaching hospital. J Mycol Médic. 25:191-199. (if=0.75, ci=Scopus, PubMed & Science Citation Index (Elsevier).) 10. Dubey D and Padhy RN (2013) Antibacterial activity of Lantana camara L. against multidrug resistant pathogens from ICU patients of a teaching hospital. J. Her. Med. 3(2):65-75. (if=1,20, ci=Scopus, PubMed & Science Citation Index (Elsevier).)

422

RAY, ARUNABHA (b 1952), Director-Professor and Head, Department of Pharmacology, Vallabhbhai Patel Chest Institute, & Dean, Faculty of Medical Sciences, University of Delhi

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Prof. Arunabha Ray has made significant contributions in the area of `stress research` and `stress pharmacology`. Using a novel and innovative approach, he integrated concepts of neuropharmacology and immunopharmacology to explain biological responses to emotional and environmental stressors and their impact on pathophysiological states. His pioneering research on the brain-gut and neuro-immune axis interactions has opened up new dimensions for understanding stress mechanisms, for which he received international recognition. Most significantly, on the basis of his studies, he proposed the role of Nitric Oxide (NO), a unique gasotransmitter, as a physiological regulator of stress and a pharmacological target for stress pathophysiology. He also showed that age and gender related differences in stress susceptibility and adaptation were under the regulatory influence of NO and suggested possible interactions of NO with cellular/molecular stress markers. His research concepts extended to the study of medicinal plants in stress related inflammatory and immunological disorders and integration of modern and traditional medicinal concepts. The translational impact of his research has been acknowledged and has led to significant publications in leading journals and invited book chapters. He is thus internationally recognized as one of the leading exponents in the field of stress research. He has received both national and international recognition/awards for his contributions and advancement of knowledge in this field. As further evidence for his scientific acumen and excellence, he actively collaborated with other leading researchers of international universities/laboratories, regularly organized scientific meetings attracting global experts and delivered guest lectures/chaired sessions in reputed international universities/conferences. Proposer: Prof. S.D. Seth, Seconder: Prof. Rup Lal Ten Best Publications: 1. Ray, A., Henke, P.G. and Sullivan, R.M. (1987). The central amygdala and immobilization stress induced gastric pathology in rats : neurotensin and dopamine. Brain Res. 409 : 398-402, ; CI-62 (if=2.89, ci=62 ) 2. Ray, A., Henke P.G. and Sullivan, R.M. (1988). Central dopamine systems and gastric stress pathology in rats. Physiol. Behav.42: 359-364 (if=3.34, ci=37) 3. Ray, A., Henke, P.G. and Sullivan, R.M. (1988). Opiate mechanisms in the central amygdala and gastric stress pathology in rats. Brain Res., 442: 195-198 (if=2.89, ci=45) 4. Ray, A., Mediratta, P.K., Puri, S. and Sen, P. (1991) Effects of stress on immune responsiveness, gastric ulcerogenesis and plasma corticosterone: modulation by diazepam and naltrexone. (if=1.19, ci=27 ) 5. Ray, A., Mediratta, P.K. and Sen, P. (1992). Modulation by naltrexone of stress induced changes in humoral immune responsiveness and gastric mucosal integrity in rats (if=3.34, ci=16) 6. Gulati K, Ray A, Masood A, Vijayan VK. (2006). Involvement of nitric oxide (NO) in the regulation of stress susceptibility and adaptation in rats (if=1.19, ci=20) 7. Pal R, Gulati K, Banerji BD, Ray A. (2011) Possible involvement of free radicals in modulation of stress-induced immunological and biochemical changes in rats (if=2.75) 8. Chakraborti A, Gulati K, Ray A. (2008). Age related changes in stress induced neurobehavioral effects in rats modulation by antioxidants and nitrergic agents (if=3.39, ci=23) 9. Chakraborti A, Gulati K, Ray A. (2014) Possible role of nitric oxide (NO) in the regulation of gender related differences in stress induced anxiogenesis in rats. (if=3.55) 10. Gulati K, Joshi JC, Ray A. (2015) Recent advances in stress research: focus on nitric oxide. Europ J Pharmacol., 765: 406 – 414 (if=2.59)

423

SHUKLA, SANGEETA (b 1961) Vice Chancellor, Jiwaji University, Gwalior

Member of the NASI: Yes (YON 2014, Medical & Forensic Sciences)

Professor Shukla, Vice Chancellor JiwajiUniversity,Gwalior, an inspiring teacher, has wide experience of research in the field of Reproductive Biology, Biochemical Pharmacology and Environmental Toxicology. In the area of health sciences, the nominee has made notable contributions in the area of toxicology and pharmacology relating to hepatic disorders, therapeutics for occupational health hazards. She introduced the concept of mechanistic toxicology for assessing risk associated with toxic substances and the need to identify the target molecules to serve as markers for detoxification of chemicals. Her studies led to the understanding of the mechanisms of detoxification by therapeutic evaluation of chelators along with co- therapy with trace elements (Se, Zn, Fe ,Ca and Mg) with special reference to Beryllium, Lead, Mercury, Vanadium and Aluminum. Her work in the area of toxicology has won her international accolades and she was awarded with the UNESCO satellite centre of trace elements study (France) which is the only centre in India.She has effectively mapped silicosis in occupationally exposed workers of the region, identifying Jaggery as an therapeutically and cost effective drug for chronically exposed patients. She has pursued hypothesis based research and has effectively utilized the modern tools to isolate and identify of potential active substances from natural resources for the treatment of liver diseases and cancer. She generated a database for 10 Unani drugs for hepatoprotection for AYUSH. She addressed the mechanism of action of natural products on DNA repair, signalling pathways and Cell cycle regulation related to hepatic disorders. Development ofa liver drug has resulted in the filing of a patentHer work is widely cited and about 30 students have received Ph.D under her supervision. She has contributed to science education and human resource development. Proposer : Prof. Vani Brahmachari, Seconder : Dr. Kiran Katoch Ten Best Publications : 1. Journal of Ethnopharmacology 111, 560 -566. 2007 Impact Factor: 3.72 Cited :128 2. Journal of Ethnopharmacology 109, 214-218. 2007 Impact Factor: 3.72Cited :102 3. Journal of Ethanopharmacology 22, 51-62. 1988 Impact Factor: 3.72Cited :60 4. Molecular and Cellular Biochemistry 302, 215-224. 2007 Impact Factor: 2.168 Cited :59 5. Food and Chemical Toxicology 46: 2703-12. 2008 Impact Factor: 2.999Cited :50 6. Journal of Ethnopharmacology 119: 218-224.,2008 Impact Factor: 3.72Cited :46 7. Experimental and Toxicologic Pathology 63 , 671-676 2011 Impact Factor: 2.781 Cited :42 8. Journal of Applied Toxicology 20, 313-318. 2000 Impact Factor: 2.478 Cited: 24 9. Indian Journal of Experimental Biology 42, 993-997.2004 Impact Factor: 1.295 Cited :26 10. Arch Toxicolology 76(8) 442-448. 2002 Impact Factor: 4.67 Cited :19

424

SINGH, MAHENDRA PRATAP (b 1970), Principal Scientist, CSIR-Indian Institute of Toxicology Research, Lucknow

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Singh used ‘omics’ in combination with classical tools to identify the signature fingerprints of pesticides-induced Parkinsonism to elucidate its molecular mechanism. He established the role of mitochondrial dysfunction, microglial activation and energy metabolism in pesticides-induced Parkinsonism. He reported the expression of glutathione-S-transferase A4-4 and cytochrome P-4502d22 genes in mouse brain and established their roles in PD (Patel et al., 2006; Singh et al., 2009; Srivastava et al., 2012). Moreover, neuroprotective mechanisms of nicotine, caffeine, melatonin, resveratrol and silymarin against pesticides-induced PD were also deciphered by him (Singh et al., 2008 and 2009; Singhal et al., 2011; Srivastava et al., 2012; Tiwari et al., 2013). He identified some proteins from blood and cerebrospinal fluid of PD patients that possess tremendous potential to be used as biomarker(s) (Sinha et al., 2007 and 2009). He reported that prolonged exposure to cypermethrin, one of the most widely used pesticides, induces Parkinsonism and deciphered its underlying mechanism (Singh et al., 2011 and 2012; Tiwari et al., 2012; Agrawal et al., 2015). Cypermethrin model offers many advantages over the classical models. It is environmentally relevant and reproduces PD features after prolonged exposure similar to sporadic PD. Cypermethrin induces striatal dopamine depletion and behavioral deficits, as a result of slow and progressive neurodegeneration that further mimics sporadic PD (Singh et al., 2011 and 2012; Tiwari et al., 2012). Proposer: Dr. Lalji Singh, Seconder: Dr. Mukul Das Ten Best Publications: 1. Gupta SP, Kamal R, Mishra SK, Singh MK, Shukla R, Singh MP* (2016). Association of polymorphism of neuronal nitric oxide synthase gene with risk to Parkinson's disease. Mol. Neurobiol. 53(5):2751-2760 (if=5.397, ci=5) 2. Agrawal S, Dixit A, Singh A, Tripathi P, Singh D, Patel DK, Singh MP* (2015). Cyclosporine A and MnTMPyP alleviate α-synuclein expression and aggregation in cypermethrin-induced Parkinsonism. Mol. Neurobiol 52(2): 1619-1628 (if=5.397, ci=5) 3. Agrawal S, Singh A, Tripathi P, Mishra M, Singh PK, Singh MP* (2014). Cypermethrin-induced nigrostriatal dopaminergic neurodegeneration alters the mitochondrial function: a proteomics study. Mol. Neurobiol. 51(2): 448-465 (if=5.397, ci=13) 4. Tiwari MN, Agarwal S, Bhatnagar P, Singhal NK, Tiwari SK, Kumar P, Chauhan LK, Patel DK, Chaturvedi RK, Singh MP*, Gupta KC (2013). Nicotine-encapsulated PLGA nanoparticles improve neuroprotective efficacy against MPTP-induced Parkinsonism. Free Rad (if=5.784, ci=22) 5. Dixit A, Srivastava G, Verma D, Mishra M, Singh PK, Prakash O, Singh MP* (2013). Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease. Biochim. Bioph (if=5.158, ci=29) 6. Yadav S, Dixit A, Agrawal S, Singh A, Srivastava G, Singh AK, Srivastava PK, Prakash O, Singh MP* (2012). Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis. Mol. Neurobi (if=5.397, ci=26) 7. Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP* (2012). Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced Parkinsonism in the mouse. Free Radic. Biol. Med. 52(8): 1294-1306 (if=5.784, ci=33) 8. Singhal NK, Srivastava G, Agrawal S, Jain SK, Singh MP* (2012). Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation? Mol. Neurobiol. 45(1): 186-199 (if=5.397, ci=54) 9. Singh AK, Tiwari MN, Upadhyay G, Patel DK, Singh D, Prakash O, Singh MP* (2012). Long-term exposure to cypermethrin induces the nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthoo (if=5.153, ci=57) 10. Singhal NK, Srivastava G, Patel DK, Jain SK, Singh MP* (2011). Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse. J. Pineal Res. 50(2): 97-109 (if=9.314, ci=82)

425

SINGH, SURENDER (b 1963), Professor, Deptt. Of Pharmacology, All India Institute Of Medical Sciences, New Delhi-110029

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Surender Singh has been faculty of pharmacology for the last twenty five years of which eleven year in All India Institute of Medical Sciences, New Delhi. He has to his credit four books, scientific series and he has over 100 scientific papers in indexed journals with cumulative impact factor of 125.64 and total citation of 2475 with h-Index 28. He has made significant contributions in the field of pharmacotherapy of inflammatory disorders using cytokine profiling and respective characterization for establishing the disease modifying agent in the treatment of rheumatoid arthritis. He is recipient of Gold Medal, M.Pharm. (Pharmacology) DIPSAR (University of Delhi), 1989, JSPS-Asia Africa Science Platform Programme, Japan Best Paper Award, 2011, All India Institute of Medical Sciences (AIIMS) Excellence Research Award, 2016, Dr. B. Mukherjee Prize for Best paper in Indian Journal of Pharmacology, 2016 and prestigious National ICMR award for biomedical research for his research contribution in the field of "Pharmacotherapy of inflammatory disorders”. He is a certified OECD-GLP Inspector of NGCMA, Department of Science & Technology, Govt. of India. He has guided 44 PhD/MD/MSc students. He is a member of several academic and scientific advisory committees. He is a Fellow of National Academy of Medical Sciences (FAMS), India, Fellow of Royal Society of Chemistry (FRSC), United Kingdom, Fellow of International Medical Science Academy, India (FIMSA) and Fellow of Institution of Chemists (FIC), India. In view of his contribution in discipline of pharmacology, I strongly recommended for the Fellowship of The National Academy of Sciences, India (NASI). Proposer: Prof. Y. K. Gupta, Seconder: Prof. N. R. Jagannathan Ten Best Publications: 1. Surender Singh, DK Majumdar and HMS Rehan (1996). Evaluation of anti inflammatory potential of fixed oil Ocimum sanctum Linn (Holy Basil) and its possible mechanism of action. Journal of Ethnopharmacology, 54: 19-26 (if=3.055, ci=171) 2. Surender Singh and DK Majumdar (1999). Evaluation of gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil) Journal of Ethnopharmacology, 65:13-19. (if=3.055, ci=131) 3. MA Jafri, M Jalis Subhani, Kalim Javed and Surender Singh (2000) Hepatoprotective activity of leaves of Cassia Occidentalis against paracetamol and ethyl alcohol intoxication in rats. Journal of Ethnopharmocology - 66:355-361 (if=3.055, ci=142) 4. MA Jafri, M Aslam, Kalim Javed and Surender Singh (2000) Effect of Punica granatum Linn (flowers) on blood glucose levels in normal and alloxan induced diabetic rats. Journal of Ethnopharmacology - 70:309-314 (if=3.055, ci=185) 5. Surender Singh, HMS Rehan and DK Majumdar (2001) Effect of Ocimum sanctum fixed oil on blood pressure,blood clotting time and pentobarbitone - induced sleeping time. Journal of Ethnopharmacology, 78:139-143 (if=3.055, ci=61) 6. PK Mediratta, KK Sharma and Surender Singh (2002) Evaluation of Immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. Journal of Ethnopharmacology, 80:15-20 (if=3.055, ci=160) 7. IG Rathish, Kalim Javed, Shamim Ahmad, Sameena Bano, MS Alam, KK Pillai, Surender Singh & Vivek Bagchi (2009). Synthesis and anti-inflammatory activity of some new 1, 3, 5 trisubstituted pyrazolines bearing benzene sulfonamide. Bioorganic & Medicin (if=2.486, ci=119) 8. Vinod Nair , Surender Singh and YK Gupta (2011) Evaluation of the disease modifying activity of Colchicum luteum Baker in. experimental arthritis. Journal of Ethnopharmacology, 133: 303-307 (if=3.055, ci=30) 9. Sameena Bano, Kalim Javed, Shamim Ahmad, I.G.Rathish, Surender Singh & M.S.Alam (2011). Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as anti-inflammatory and anticancer agents. European Journal (if=3.902, ci=57) 10. R Basir,Surender Singh & K Javed (2011) Synthesis of some new 1, 3, 5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters,21(14):4301-4305 (if=2.486, ci=61)

426

TRIPATHI, ARVIND (b 1958), Professor & Head, Prosthodontics, Dean, Postgraduate Studies & Research, Saraswati Dental College & Hospital, Lucknow

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr. Arvind Tripathi, embarked on a career in teaching Prosthodontics in December 1985 with an appointment at the Faculty of Dental Sciences King George's Medical College, Lucknow. He was a WHO fellow in Maxillofacial Prosthetics at USA and Canada in 1998, He has also been an American Cancer Society fellow in Maxillofacial Prosthetics in 2001-02. He started a training program in Maxillofacial prosthetics and offered adjunct services to patients of Surgical Oncology, Plastic surgery Pulmonary medicine and ENT. for post surgical rehabilitation. Dr .Tripathi joined Saraswati Dental College & Hospital, Lucknow in December 2008 as Dean PG studies and Research and was able to instill the spirit of Dental research in the Institution. He developed a diversified Postgraduate curriculum in his Department of Prosthodontics, introducing three new additional sub-specialities—Maxillofacial prosthetics, Cleftlip & palate prosthetics, Dental Sleep Medicine and Geriatric oral health. This is the first such successful effort in India, and students trained by Dr. Tripathi are proficient in treating a wider variety of Prosthodontic patients. At the same time this effort has elevated the value of Prosthodontics as an adjunct to Surgical oncology, Plastic Surgery, Pulmonury Medicine and Otorhinolaryngology. .Dr.Tripathi is also currently pursuing a PhD. programme in Dental Sleep Medicine. In appreciation of his unique effort to diversify Postgraduate academic instruction, which is the first of its kind in India and providing free treatment to such patients, I propose his nomination for the Fellowship of NASI. Proposer : Dr. Nitya Anand, Seconder : Prof. Ten Best Publications: 1. Tripathi Arvind, Kar Sushil K, and SinghSaumyendraV.: A novel technique for making impressions in Maxillectomy patients with Trismus: Int'l J. Pros. Dent2013:4(1):36-39. 4. (if=unknown, ci=nil) 2. Singh Ronauk, Tripathi Arvind, Dhiman R K, Kumar Dinesh. Intrapulpal thermal changes during direct provisionalization using various autopolymerizing resins: Ex-vivo study. Medical Journal Armed Forces India xxx (2013)1-8. 2. (if=unknown, ci=nil) 3. Parlani Swapnil, Tripathi Arvind, Singh, Saumyendra V.: Increasing the prosthodontic awareness of an aging Indian rural population. Indian J. of Dental Research, Vol-22(3), Nov 2011 (Citation 1) (if=unknown, ci=1) 4. Tripathi Arvind, Kar Sushil K, and SinghSaumyendraV.: A novel technique for making impressions in Maxillectomy patients with Trismus: Int'l J. Pros. Dent2013:4(1):36-39. 4. (if=unknown, ci=nil) 5. Singh Ronouk, Tripathi Arvind, Singh Saumyendra V., & Bhatnagar Atul: A Study on the Practical Applicability of the Rule of Golden Rectangle in Dental Aesthetics. Eur.J. Prosthodont. Rest. Dent. Vol 19, No. 2, pp 85-89, 2011 (Citation 1) 9. (if=unknown, ci=1) 6. Tripathi, Arvind, Pandey, Saumya, Singh, Saumyendra V., Sharma, Naresh Kumar,and Singh, Ronouk: Bisphosphonate therapy for malignancies and metastases: impact on jawbones and prosthodontic concerns Journ.of Prosth.Vol.20 603-611,2011. (Citations 3)(if=0.681, ci=3) 7. Goel Ashima, Tripathi Arvind, Pooran Chand, Singh Saumyendra Vikram,Pant M.0 and Nagar Amit : A study on the use of positioning stents in lingual carcinoma patients subjected to radiotherapy Accepted for publication Int. Journ. Prosth Vo123;450-4525ep2010 (Citations 1) 11. (if=1.625, ci=1) 8. Arya Deeksha, Tripathi A, Singh SV, Surya Kant, Mishra A and Nagar A: A study to evaluate Post Treatment cephalometric changes in subject having Oral Sleep Apnea Vol 103:170-177 Journ. Prosth.Dent. Mar.2010. (Citations 7) 12. (if=2.104, ci=7) 9. Singh SV, Tripathi A. An overview of osteoporosis for the practising prosthodontist. Gerodontology 2010; 27(4): 308-14 (Citations 2)(if=1.826, ci=2) 10. Singh, Balendra Pratap, Tripathi Arvind, SinghMan Mohan, Makker Annu and Singh Saumyendra Vikram:: Evaluation of Bone Mineral Density and Testosterone level on Tooth Loss. Indian J. Stomatol 2013;4(1):9-13 3. (if=unknown, ci=unknown)

427

VUTHALURU, SEENU (b 1962), Professor, Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi

Member of the NASI: No (YON 2014, Medical & Forensic Sciences)

Dr Vuthaluru Seenu has been working in the Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India since 1990. As a faculty member, he has guided many medical graduates to conduct research & publish in peer reviewed journals. AIIMS attracts externs from different Asian and westerner countries & he, as part of AIIMS endeavour has given them exposure to common tropical surgical diseases. AIIMS also gets trained surgeons from Armed Forces & rural hospitals as observers. He has been actively involved in training them in breast, laparoscopic surgery & renal transplantation. His research focus is on applying newer advances of treatment to patients in local settings. His area of interest in research is breast cancer. He is the first Indian investigator to perform & publish data on sentinel node biopsy in breast and other cancers in the country Our group is recognised for our work pertaining to locally advanced breast cancer and evaluation of sentinel node using Magnetic Resonance Spectroscopy which has been published in peer reviewed journals. Dr Seenu has published pioneering work on sentinel node biopsy for eye lid cancers in peer reviewed journals.He is a member of many national & international scientific academies & fellow of American College of Surgeons (FACS), international union against cancer (FUICC), International College of Surgeons (FICS) & WHO. He is a recipient of many national and international awards for his work in the field of breast cancer & has delivered prestigious orations. Proposer : Prof. N.R. Jagannathan, Seconder : Prof. T.P. Singh Ten Best Publications: 1. Kapur BML, Misra MC, Seenu V,Goel AK. 1998 Pancreatogastrostomy for reconstruction of pancreatic stump after pancreaticoduodenectomy for ampullary carcinoma Am J Surg. 176:274-78. (if=2.7, ci=41) 2. Jagannathan NR, Kumar M, Seenu V et al.2001 Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer. Br J cancer. 84: 1016-22. (if=5.08, ci=230) 3. Seenu V, Pavan Kumar MN, Uma S, Datta Gupta S, Jagannathan NR, Mehta SN. 2005 Potential of magnetic resonance spectroscopy to detect metastasis in axillary lymph nodes in breast cancer. Mag Res Spectroscopy. 23: 1005-10. (if=2.06, ci=27) 4. A Kumar, R Kumar, V. Seenu. 2009. The role of 18F FDG Pet/CT in evaluation of early response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Eur Rad; 19;147-1357. (if=1.6, ci=71) 5. Seenu V, Habal N. Giuliano 1999. A. Sentinel node and breast cancer: A new paradigm. Nat Med J India. 1999; 12: 253-57 (if=0.91, ci=6) 6. Seenu V, Pal H, Chattopadhyay TK. Quality of life after total esophagectomy for esophageal cancer. Trop Gastroenterol. 2001; 22: 7-13. (if=0.8, ci=153) 7. NK Shukla, A Goel, V. Seenu 1994. Endoscopically guided placement of nasogastric tube in patients with esophageal carcinoma with absolute dysphagia. J Surg Oncol 56(4) 217-220 (if=2.64, ci=15) 8. V. Seenu, A Hafiz.2005. Routine antibiotic prophylaxis is not necessary for no scalpel vasectomy Int Urol Nephrol 37; 763-765(if=1.33, ci=9) 9. Seenu V, Shridhar D, Bal CS, Parshad R, Kumar A. Laparascopic cholecystectomy: Cystic duct occlusion with titanium clips or ligature 2005: A prospective randomized study. Trop Gastroentero 25: 180-83. (if=0.8, ci=9) 10. S Vuthaluru, Pushkar N, G Lokadarshi et al.2013 Sentinel lymph node biopsy in malignant eyelid tumor: Hybrid SPECT/CT and dual dye technique. 156 (1) 43-49. (if=4.29)

428

BISWAS, JYOTIRMAY (b 1954), Director of Uveitis & Ocular Pathology department, Medical Research Foundation, Sankara Nethralaya, Chennai. INDIA. Mobile No:9841428151

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

I know Dr. Jyotirmay Biswas from his undergraduate days through his residency in ophthalmology at PGIMER Chandigarh and then as ocular pathology and uveitis fellow at Doheny Eye Institute, Los Angeles and subsequently as an international leader in the field of uveitis and ocular pathology after returning to Sankara Nethralaya. He is prolific writer publishing over 350 peer reviewed papers in national international first rate journals. His major contributions include seminal publications on Eales’ disease, ocular complications in HIV/AIDS and nucleic acid amplifications in diagnosis and treatment of intraocular tuberculosis which appeared in major international journals. Moreover, he is well recognized fair reviewer with great insight in providing constructive reviews and to his credit he provided numerous reviews to ophthalmic journals from India, Europe, and United States. In addition being talented academician, clinician and administrator, he trained and mentored more than 50 ophthalmologists in uveitis and ophthalmic pathology and his trainees now lead in various parts of India where they established uveitis services and ocular pathology labs. He also possesses leadership quality and was instrumental in starting uveitis society in India, served as president of this and ophthalmic pathology society. He organized several international meeting international uveitis study group and international ocular inflammation society. His selection to fellowship to this august academy will only further enhance the stature of our august organization and the society can use his expertise in ophthalmology to further its interested in the subject. I strongly endorse his candidature for the fellowship. Proposer: Prof. Kanjaksha Ghosh, Seconder: Dr. Dipika Sur Ten Best Publications: 1. Biswas J, Madhavan H N, Gopal L, Badrinath S S: Intraocular tuberculosis. Retina, 1995;15:461-8. (if=3.039 , ci=119) 2. Biswas J, Badrinath SS: Ocular morbidity in patients with active systemic tuberculosis. International Ophthalmology. 19:293-98, 1996. (if= 0.60 , ci=80) 3. Biswas J, Narain S, Das D, Ganesh SK: Pattern of uveitis in a referral uveitis clinic in India. International Ophthalmology. International Ophthalmology 20:223-228, 1996. (if=0.60 , ci=122) 4. Biswas J, Madhavan HN, George AE, Kumarasamy N, Solomon S. Ocular lesions associated with HIV infection in India: A series of 100 consecutive patients evaluated at a referral center. Am J Ophthalmol Vol. 129, No. 1, 9-15, 2000. (if=3.831 , ci=116 ) 5. Madhavan HN, Therese KL, Gunisha P, Jayanthi U, Biswas J. Polymerase chain reaction for detection of mycobacterium tuberculosis in epiretinal membrane in Eales' disease. IOVS, 2000;41(3):882-25. (if=3.427, ci=137) 6. Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishan S. Eales’ disease – An update. Survey of Ophthalmology. 2002; 47(3): 197-214. (if=3.292 Citation Index : , ci=171 ) 7. Biswas J, Das D, Krishnakumar S, Shanmugam MP. Histopathologic analysis of 232 eyes with retinoblastoma conducted in an Indian tertiary – care ophthalmic center. J Pediatr Ophthalmol Strabismus 2003; 40: 265-67. I (if=0.41 , ci=38) 8. Biswas J, Fogla R, Srinivasan N, Narayan S, Haranath K, Badrinath V: Clinical and Histopathological findings of ocular malaria - A study of three cases. Ophthalmology 103:9:1996. (if=6.1 , ci=25 ) 9. Babu RB, Sudharshan S, Kumarasamy N, Therese L, Biswas J. Ocular Tuberculosis in Aquired Immunodeficiency Syndrome. Am J Ophthalmol 2006; 142- 413-418. (if=3.831, ci=74) 10. Biswas J, Ravi RK, Narayanasamy A, Kulandai LT, Madhavan HN. Eales’ disease – current concepts in diagnosis and management. J Opthalmmic Inflammation Infect. 2013;14:3(1): 11- 12. (if=1.81 , ci=16)

429

CHHIBBER, SANJAY (b 1955), Professor, Department of Microbiology, Panjab University, Chandigarh

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Phage therapy and anti-virulence approaches are being investigated in Prof. Chhibber’s laboratory in a pursuit to develop novel drugs as alternatives to traditional antibiotics. The research on isolation, characterization and therapeutic potential of bacteriophages against respiratory and wound infections in normal and diabetic mice has shown promising results. Their entrapment in nano lipoidal delivery vehicles, in order to increase their availability in vivo, counter neutralization by specific antibodies and facilitate their entry into macrophages has yielded encouraging results. These antibacterial agents with narrow activity are recommended for oral, topical and parenteral administration for the treatment of both gram negative and positive bacteria. The observations made in the laboratory also suggest their use in a prophylactic fashion as decolonizers for eradicating nasopharyngeal carriage and preventing bacterial contamination of orthopaedic implants. Currently the focus is on phage lysins, highly potent enzymes degrading bacterial cell wall. These have been cloned, expressed and being developed to take care of infections caused by Staphylococcus aureus and Streptococcus pneumoniae. Targetting bacterial virulence is another attractive option and studies in the laboratory on Gingerone, a phytochemical, have shown it to be inhibitor of quorum sensing in Pseudomonas aeruginosa, directly suppressing virulence of this pathogen including biofilm formation. On the basis of these results and docking studies it is being recommended as a drug candidate having anti virulence and anti inflammatory property. Currently an attempt to develop and evaluate the potential of conjugate vaccine containing either acyl homoserine lactone or anti yersiniabactin receptor protein approach is being made in the laboratory. Proposer : Prof. R.K. Kohli, Seconder : Prof. Arun K. Grover Ten Best Publications: 1. Mittal, R., Aggarwal, S., Sharma, S., Chhibber, S and Harjai, K. Urinary tract infection caused by Pseudomonas aeruginosa : A mini review. J. Infection and Public Health. 2 (3) : 101 – 111, 2009. (if=1.08, ci=74) 2. Chhibber, S Kaur, S Kumari . Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice [S; Journal of Medical Microbiology 57 (12), 1508-1513] (2008) (if=2.5, ci=28) 3. Verma, V., Harjai, K and Chhibber, S. Characterization of a T7-like bacteriophage of Klebsiella pneumoniae B5055: A potential therapeutic agent. Curr. Microbiol. 59, 274 – 281, 2009 (if=1.33, ci=40) 4. Verma V, Harjai, K and Chhibber, S. Structural changes induced by lytic bacteriophage make ciprofloxacin effective against older biofilm of Klebsiella pneumoniae. Biofouling. 26(6): 729-737, 2010 (if=4.41, ci=36) 5. Kumari, S., Harjai, K and Chhibber, S. Efficacy of bacteriophage treatment in murine burn wound infection induced by Klebsiella pneumoniae. J. Microbiol. Biotechnol. 19(6): 622-628, 2009 (if=2.0, ci=32) 6. Verma, V., Harjai, K and Chhibber, S. Restricting ciprofloxacin – induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment. J. Antimicrobial Chemother. 64(6): 1212-1218, 2009 (if=4.35, ci=29) 7. Bansal, S and Chhibber, S. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055 induced lung infection in BALB/c mice. J. Med. Microbiol. 59: 429-437, 2010 (IM: 2.27) (if=2.27, ci=28) 8. Co-Therapy Using Lytic Bacteriophage and Linezolid: Effective Treatment in Elimianting Methicillin Resistant Staphylococcus aureus (MRSA) from Diabetic Food Infection [S Chhibber, T Kaur, S Kaur; PLOS one] (if=4.09, ci=21) 9. Kumari, S., Harjai, K. and Chhibber, S. Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055. J. Med. Microbiol 60: 205-210, 2011. (if=2.27, ci=30) 10. Kumar L, Chhibber S, Harjai K. (2014) Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model. PLoS One. 2014 Sep 3;9(9):e106536. doi: 10.1371/journal.pone.0106536. eCollection 2014. (if=3.7)

430

KANNABIRAN, CHITRA (b 1960), Scientist, L.V. Prasad Eye Institute, Hyderabad

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Dr Chitra Kannabiran is an outstanding molecular geneticist with special focus during the last 20 years on the genetic aspects of hereditary eye diseases. This is a widely neglected area in India, a country which contributes to over 15% of hereditary eye diseases across the world, and a country where intra- community and consanguineous marriages are widely practised. She has devoted her full attention to studying the genetic basis of several types of inherited blinding diseases such as congenital cataract, corneal dystrophies and retinal dystrophies. To this end, she has worked for much of her career in active and intensive collaboration with clinical ophthalmologists at L.V. Prasad Eye Institute, Hyderabad, where she is the seniormost basic research scientist. Some of her notable contributions are- 1) identification of a novel splice mutation in the human beta A1/A3-crystallin gene, leading to deletion of 2 exons with dense congenital cataracts in the affected family; 2) mutation in a gap junction protein gene (connexin) in lens, leading to congenital autosomal recessive cataract; she has further studied the functional loss in the activity of the membrane-associated connexin protein in the lens fiber cells; 3) her genetic analysis of a rare form of corneal dystrophy is noteworthy; 4) Her latest paper in Nature genetics on the association between the gene for NMNAT1 (involved in biosynthesis of NAD) with a childhood-onset retinal disease termed Leber Congenital Amaurosis. These have led her to plan with collaborating clinicians to try and initiate gene therapy for certain retinal disorders.

Proposer : Prof. D. Balasubramanian, Seconder : Prof. R.V. Sonti Ten Best Publications: 1. Marni J. Falk, Qi Zhang, Eiko Nakamaru-Ogiso, Chitra Kannabiran, Zoe Fonseca-Kelly, Christina Chakarova, et al. NMNAT1 Mutations Cause Leber Congenital Amaurosis. Nature Genet (published online July 2012) doi:10.1038/ng.2361. (IF=30) 2. Kannabiran C, Singh HP, Jalali S. Mapping of locus for autosomal dominant retinitis pigmentosa on chromosome 6q23. Hum Genet. 2012; 131:717-723. (IF=6.0) 3. Singh HP, Jalali S, Narayanan R, Kannabiran C. Genetic analysis of Indian families with autosomal recessive retinitis pigmentosa by homozygosity screening. Invest Ophthalmol Vis Sci. 2009;50 (9):4065- 71. Epub 2009 Apr 1. (IF=3.6, CI=9) 4. Ponnam SP, Ramesha K, Tejwani S, Matalia J, Kannabiran C. A missense mutation in LIM2 causes autosomal recessive congenital cataract. Mol Vis. 2008 Jun 23;14:1204-8. PubMed PMID: 18596884 (IF=2.7, CI=17) 5. Ponnam SP, Ramesha K, Tejwani S, Ramamurthy B, Kannabiran C. Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract. J Med Genet. 2007 Jul;44(7):e85. (IF=7.0, CI=36) 6. Friedman JS, Chang B, Kannabiran C, Chakarova C, Singh HP, Jalali S, et al. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet. 2006 Dec;79(6):1059-70. (IF=10.0, CI=43) 7. Jiao X, Sultana A, Garg P, Ramamurthy B, Vemuganti GK, Gangopadhyay N, Hejtmancik JF, Kannabiran C. Autosomal recessive corneal endothelial dystrophy (CHED2) is associated with mutations in SLC4A11. J Med Genet. 2007 Jan;44(1):64-8. (IF=7.0, CI=39) 8. Kannabiran C, Klintworth GK. TGFBI gene mutations in corneal dystrophies. Hum Mutat. 2006 Jul;27(7):615-25. (IF=6.0, CI=74) 9. Kannabiran C, Rogan PK, Olmos L, Basti S, Rao GN, Kaiser-Kupfer M, Hejtmancik JF. Autosomal dominant zonular cataract with sutural opacities is associated with a splice mutation in the betaA3/A1- crystallin gene. Mol Vis. 1998 Oct 23; 4:21. (IF=2.7, CI=107) 10. Singh HP, Jalali S, Hejtmancik JF, Kannabiran C. Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy. Am J Ophthalmol. 2006 (IF=3.0, CI=5)

431

MANDAL, NRIPENDRANATH (b 1959), Professor, Bose Institute, Kolkata

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Prof. Mandal’s outstanding research has contributed in the development of better and safer drug using natural resources against ROS-induced various degenerative diseases like cancer while avoiding the detrimental side effects of conventional therapies involving synthetic drugs. His group explored 45 medicinal plants/algae/lichen for potent antioxidative and free radical scavenging efficacies (54 publications), out of which 14 are safe and orally-administrable drug to release iron in iron-overload- induced hepatotoxic condition (17 publications). Moreover, among these, 12 have shown in vitro anticancer effects in various cancer cell lines by inducing apoptosis and/or regulation of cell cycle, while being nontoxic to the normal cells (13 publications). For the first time, his group explored a lichen extract as a better and safer drug against breast cancer where its individual phytochemicals lost this selectivity (Ghate et al., 2013) and was highly appreciated in 9 different news media. His group, through multivariate analysis from case control study, has shown that ratio of different apolipoproteins and LDL particle size along with distribution of ABO blood group are potent biomarkers of CHD among Asian Indian population in Eastern part of India. He also found the association of E4 allele with CAD and the ratio of anti- to pro- inflammatory cytokine with Acute Myocardial Infarction. From the prevention point of view these will play a pivotal role to develop biometric chip for early prediction of CHD (5 publications). Proposer: Prof. Sekhar Chakrabarti, Seconder: Prof. Sampa Das Ten Best Publications: 1. Ghate,et al. (2016) Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio. Nature-Cell Death Discovery 2, 15062. (ci=01) 2. Gupta et al. (2016) Novel BODIPY-based Ru (II) and Ir (III) Metalla-rectangles: Cellular Localization of Compounds and Their Antiproliferative Activities. Chemical Communications 52, 4274 – 4277. (if=6.567, ci=03) 3. Panja et al. (2016) A microalga, Euglena tuba induces apoptosis and suppresses metastasis in human lung and breast carcinoma cells through ROS-mediated regulation of MAPKs. Cancer Cell International 16: 51. (if=2.884, ci=00) 4. Ghate,et al. (2015) An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice. PLoS ONE 10(5): e0128221. (if=3.057, ci=04) 5. Chaudhuri et al. (2015) Wild Edible Fruit of Prunus nepalensis Ser. (Steud), a Potential Source of Antioxidants, Ameliorates Iron Overload-Induced Hepatotoxicity and Liver Fibrosis in Mice. PLoS ONE 10(12): e0144280. (if=3.057, ci=01) 6. Panja et al. (2014) Phytochemical profile of a microalgae Euglena tuba and its hepatoprotective effect against iron-induced liver damage in Swiss albino mice. Journal of Applied Microbiology 117, 1773-1786 (if=2.386, ci=03) 7. Biswas et al. (2014) Synergistic effect of anti and pro-inflammatory cytokine genes and their promoter polymorphism with ST-elevation of myocardial infarction. Gene 544(2): 145-151 (if=2.319, ci=13) 8. Ghate,et al. (2013) An antioxidant extract of tropical lichen, Parmotrema reticulatum, induces cell cycle arrest and apoptosis in breast carcinoma cell line MCF-7 PLoS ONE 8(12): e82293. (if=3.057, ci=25) 9. Hazra et al. (2008) Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complementary and Alternative Medicine 8: 63 (if=2.94, ci=392) 10. Biswas et al. (2008) Association of low-density lipoprotein particle size and ratio of different lipoproteins and apolipoproteins with coronary heart disease. Journal of Cardiology 52: 118-126. (if=2.405, ci=11)

432

NALLARI, PRATIBHA (b 1957), Professor, Coordinator, CASII, Dept of Genetics, , Hyderabad

Member of the NASI: No (YON 2013, Medical & Forensic Sciences) I am happy to propose Dr. Pratibha Nallari as a Fellow of National Academy of Sciences, India whom I know as a pioneer in carrying out considerable research on very rare disorders in Indian Population such as Cardiomyopathy, Long QT syndrome and Idiopathic Pulmonary Arterial Hypertension (IPAH) for which drug targets haven’t been identified. Dr. Nallari’s research on heritable cardiomyopathies revealed an association with a deletion in cardiac Myosin Binding Protein C gene which is associated with an increased risk of heart failure in South Asian populations (Nature Genetics 2009). Apart from this, she has identified 86 novel mutations which are deposited to NCBI database which can be considered as diagnostic markers as well as therapeutic targets for these rare disorders. To validate the functional aspects of these novel mutations, cloning and cell lines studies are being carried out. Dr. Nallari’s highly enthusiastic activity on identification of genetic markers for IPAH has earned her not only national level funding but also attracted International collaborations with University of Lincoln, UK and could identify new candidate genes and novel mutations in Indian Cohort, funded internationally by GlaxoSmithKline, UK. Her collaboration with Sick Kids Hospital, Toronto for carrying out Exome analysis of ARVD/C samples revealed various nuclear and mitochondrial genes in the etiology of ARVD/C which are the stepping stones for developing diagnostic kits/potential drug targets. Recently she has identified drug responsive genotypes and biomarkers in the etiopathogenesis of LQT syndrome, a rare SCD disorder, funded by DBT (New Delhi 2014). Proposer : Dr. G. Bhanuprakash Reddy, Seconder : Dr. V. Dashavantha Reddy Ten Best Publications: 1. Deepa Selvi Rani, Perundurai S. Dhandapany, Pratibha Nallari, Calambur Narasimhan, Kumarasamy Thangaraj. (2014) “A Novel Arginine to Tryptophan (R144W) Mutation in Troponin T (cTnT) Gene in an Indian Multigenerational Family with Dilated Cardiomyopathy (FDCM)”. PLoS ONE, 9(7): e101451. (if=3.73) 2. Sabnavis, Sowmya; Sri Manjari, K; Ramaiah, Aruna; Tella, Sunitha; Nallari, Pratibha; Akka, Jyothy; Venkateshwari, A. (2014) “Interleukin 10 Gene Promoter Polymorphisms in Women with early onset Preeclampsia”. Clin Exp Immunol, 178(2): 334-41. (if=3.32, ci=2) 3. Lova Satyanarayana Matsa, Someswar Rao Sagurthi, Venkateshwari Ananthapur, Swapna Nalla, Pratibha Nallari. (2014) “Endothelin1 Gene As A Modifier In Dilated Cardiomyoapthy”. Gene, 548(2): 256- 62. (if=2.196, ci=1) 4. Lova Satyanarayana M, Advithi R, Viswamitra V, Mona Latifi, Hossein MJ, Venkateshwari A, Pratibha N. (2013) “Haplotypes of NOS3 Gene Polymorphisms in Dilated Cardiomyopathy” PLoS ONE, 8(7); 1- 5. (if=3.73, ci=8) 5. Gayatri Ramachandran & Manoj Kumar, Deepa Selvi Rani, Ananthapur Venkateswari, Calambur Narasimhan, Pratibha Nallari, Punit Kaur. (2013) “An In silico Analysis of Troponin I Mutations of Indian Origin in Hypertrophic Cardiomyopathy” PLoS ONE, 8(8); 1-8.(if=3.73, ci=2) 6. Deepa SR, Pratibha N, Narasimhan C, Thangaraj K. (2011) " Cardiac Troponin T (TNNT2) Mutations Are Less Prevalent in Indian Hypertrophic Cardiomyopathy Patients" DNA and Cell Biology, 31(4): 616- 624. (if=2.159, ci=7) 7. Laksmi Rao, Murthy Kanakavalli, Raseswari Turlapati, Pratibha Nallari, Lalji Singh. (2010) “Paternally derived translocation t(8;18)(q22.1;q22)pat associated in a patient with developmental delay: Case report and review” Journal of Pediatric Neurosciences, 5: 64-67.(if=2.26, ci=3) 8. Hridesh Dixit, Lakshmi Rao, Pratibha Nallari, Venkata Padmalatha, Turlapati Raseswari, Anil Kumar Kapu, Bineet Panda, Durgadutta Tosh, Mamata Deendayal, Nalini Gupta, Baidyanath Chakrabarthy, Lalji Singh. (2010) “Genes Governing premature ovarian failure”, RBMO, 20: 724-740. (if=3.26, ci=27) 9. Deepa Selvi Rani, Perundurai S. Dhandapany, Pratibha Nallari, Periyasamy Govindaraj, Lalji Singh, Kumarasamy Thangaraj. (2010) “Mitochondrial DNA Haplogroup ‘R’ is Associated with Noonan syndrome of South India”, Mitochondrion, 10(2): 166-73. (if=4.2, ci=20) 10. Perundurai S Dhandapany, Sakthivel Sadayappan, Yali Xue, Gareth T Powell, Deepa Selvi Rani, Pratibha Nallari, Taranjit Singh Rai, Madhu Khullar, Pedro Soares, Ajay Bahl, Jagan Mohan Tharkan, Pradeep Vaideeswar, Andiappan Rathinavel, Calambur Narasimhan, Dharma Rakshak Ayapati, Qasim Ayub, S Qasim Mehdi, Stephen Oppenheimer, Martin B Richards, Alkes L Price, Nick Patterson, David Reich, Lalji Singh, Chris Tyler-Smith & Kumarasamy Thangaraj. (2009) “A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia”, Nature Genetics 41, 187 – 191. (if=39.794, ci=140) 433

PARTHASARATHY, SATISHCHANDRA (b 1953), Ex-Director-Vice Chancellor and Sr. Professor of Neurology, National Institute of Mental Health and Neurosciences, Bangalore

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Prof. Satish Chandra, Director/Vice Chancellor NIMHANS, is an internationally recognized Epiloptologist and contributed to the characterization of different unique entities like Hot Water Epilepsy and Myoclonic Epilepsy common to South India. He bridged the clinical knowledge to electrophysiology, pathology, genetics and management thus offering a comprehensive knowledge to the world and to patient care. He is an expert in the field of Neuro-infections with special reference to HIV/AIDs and studied the HIV dementia in the longitudinal follow up and associated opportunistic infections and Immune Re-constitution Syndrome. He has numerous widely quoted national and international publications in these fields. He lead two prestigious RO1 projects supported by NIH, USA in collaboration with Miami University and John Hopkins Medical Centre. He is involved in the cause of National Mental Health Programme as an advisor to Govt of India and disseminate the knowledge to the general public. He is instrumental in getting Institute of National Importance status to NIMHANS by pursuing with the Govt of India. He has been championing human rights by establishing a Free Legal Aids Centre at NIMHANS for the first time in India. Under his leadership a Centre for Well Being has been established to promote positive mental health in the society. Prof.Satish Chandra is respected as a compassionate and professional neurologist and a teacher. He is an academician and an administrator par excellence and a benevolent leader enrolling the faculty in the decision making and promoting the growth of NIMHANS, leading from the front. Proposer : Dr. Devika Nag, Seconder : Dr. S.K.Shankar Ten Best Publications: 1. Satishchandra P., Shivaramakrishna A., Kalaiperumal VG., Schoenberg BS. Hot-Water Epilepsy: A variant of reflex epilepsy in southern India. Epilepsia 1998, 29: 52-56. (if=4.584 (2014), ci=68) 2. Acharya JN., Satishchandra P., Asha T., Shankar SK., Laforas-disease in South-India - A clinical, electrophysiologic, and pathological study. Epilepsia 1993; 34 476-487. (if=4.584 (2014), ci=44) 3. Minnassin BA., Lee JR., Herbrick J., Hulzenga J., Soder., Mungall AJ., Dunham J., Gardner R., Fong GC., Carpenter S., Jardim L., P. Satishchandra, Andermann E., Snead OC., Cender LI., Tsui L., Delgado- Esequeta AV., Rouleau GA., Scherer SW. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy, Nature Genetics, 20 (2), 171-174, 1998.(if=29.648 (2014), ci=276) 4. Singh S, Satishchandra P., Shankar SK., Ganesh S. in the Indian population: EPM2A and NKLRC1 gene mutations and their impact on subcelluar localization of laforin and malin. Hum. Mutat. 29 (6): 1-12. 2008 (if=7.033 (2008), ci=11) 5. Kapoor, A, Satishchandra P., Ratnapriya R., Reddy R., Kadandale J., Shankar SK., Anand A. An idiopathic epilepsy syndrome linked to 3q13.3-q21 and missense mutations in the extracellular calcium sensing receptor gene. Ann Neurol. 2008, 64, 158-67. (if=9.935 (2008), ci=14) 6. Ratnapriya R., Satishchandra P., Kumar SD., Gadre G, Reddy R., Anand A. A locus for autosomal dominant reflex epilepsy precipitated by hot water maps at chromosome 10q21.3-q22.3. Human Genet 2009, 125, 541-549. (if=4.523 (2009), ci=12) 7. Satishchandra, P; Nalini, A; Gourie-Devi, M; Khanna, N; Santosh, V; Ravi, V; Desai, A; Chandramuki, A; Jayakumar, PN; Shankar, SK. Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96), Indian Journal of Medical Research. 2000, 111:14-23. (if=1.661 (2014), ci=81) 8. GuptaJD., Satishchandra P., Gopalkumar K., Wilkie F., Waldrop-Valverde D., Ellis R, Ownby R., Subbakrishna DK., Desai A., Kamat A., Ravi V., Rao BS., Satish KS., Kumar M. Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India. J.Neuroviol, 2007, 13, 195-202. (if=3.323 (2014), ci=49) 9. MS Kim, SM Pinto, D Getnet, RS Nirujogi, SS Manda. Satishchandra P., Harsha Gowda and Akilesh Pandey. A draft map of the human proteome, Nature 509: 575-589, 2014. (if=42.351 (2014), ci=137) 10. Satishchandra P, Sinha S. Progressive myoclonic epilepsy. Neurol India, 58(4):514-522, 2010 (if=0834, ci=12)

434

RANI, RAJNI (b 1955), Staff Scientist VII, National Institute of Immunology, New Delhi

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Dr. Rajni Rani has made significant contributions in the area of Molecular Immunogenetics having far reaching implications in disease prognosis and management of several important autoimmune and infectious diseases like psoriasis, Type 1 diabetes, vitiligo, hypoparathyroidism and leprosy. Her work on type 1 diabetes demonstrated integrated roles of different cytokine genes, insulin gene, predisposing MHC alleles and vitamin D receptor gene in autoimmune Th1 responses against the beta cells of the pancreas. She has shown elegantly that different manifestations of diseases like leprosy and vitiligo could be due to MHC molecules with distinct molecular signatures for the peptide binding groove responsible for the presentation of peptides. She has published the largest studies on vitiligo and hypoparathyroidism providing strong evidence for autoimmune nature of these diseases with a strong genetic factor for predisposition to develop these diseases in the highly polymorphic MHC complex. Her work received well- deserved recognition in the form of a commentary in Journal of Investigative Dermatology, a Nature Press journal. Recently she has been involved in studying the melanocyte-keratinocyte biology and their interactions to understand the disappearance of pigment producing melanocytes in vitiligo. She is a very talented Immunogeneticist and a scientist with clarity of work who has consistently worked on disease related issues with human materials and subjects during the entire span of her career. Her studies have a direct bearing on understanding the etiology and genetic factors associated with human diseases. It is because of this unique expertise and ability she should be recognized. Proposer : Dr. Chandrima Shaha, Seconder : Dr. Sher Ali Ten Best Publications: 1. Natarajan VT, Ganju P, Singh A, Vijayan V, Kirty K, Yadav S, Puntambekar S, Bajaj S, Dani P, Kar HK, Gadgil CJ, Natarajan K, Rani R and Gokhale RS. (2014)IFN-γ signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation. Proceedings of National Academy of Sciences, USA, 2014, 111 : 2301-2306 (if=9.74 (current), ci=Just published) 2. Goswami R, Singh A, Gupta N, Consortium IGV, Rani R. (2012). Presence of strong association of the Major Histocompatibility Complex (MHC) Class I allele HLA-A*26:01 with idiopathic hypoparathyroidism. Journal of Clinical Endocrinology and Metabolism. Journal of Clinical Endocrinology and Metabolism.97 : E1820-E1824; doi:10.1210/jc.2012-1328. (if=6.5 (corresponding year), ci=cited by 2) 3. Singh A, Sharma P, Kar HK, Sharma VK, Tembhre MK, Gupta S, Laddha NC, Dwivedi M, Begum R; The Indian Genome Variation Consortium, Gokhale RS, Rani R. (2012). HLA alleles and amino acid signatures of the peptide binding pockets of HLA molecules in Vitiligo. Journal of Investigative Dermatology. 132(1):124-134; http://dx.doi.org/10.1038/jid.2011.240. (if=6.193 (corresponding year), ci=cited by 16) 4. Natrajan VT, Singh A, Kumar AA, Sharma P, Kar HK, Marrot L, Meunier JR, Natarajan K, Rani R and Gokhale RS. (2010). Transcriptional Upregulation of Nrf2-dependent Phase II Detoxification Genes in the Involved Epidermis of Vitiligo Vulgaris Journal of Investigative Dermatology.130: 2781-2789; doi:10.1038/jid.2010.201. (if=6.31 (corresponding year), ci=cited by 15) 5. Israni N, Goswami R, Kumar A, Rani R. (2009). Interaction of vitamin D receptor with HLA-DRB1*0301 in Type 1 diabetes patients from North India. PLoS One. 4(12): e8023. doi:10.1371/journal.pone.0008023I (if=4.41 (corresponding year), ci=cyted by 20) 6. Spierings E, Hendriks M, Absi L, Canossi A, Chhaya S, Crowley J, Dolstra H, Eliaou JF, Ellis T, Enczmann J, Fasano ME, Gervais T, Gorodezky C, Kircher B, Laurin D, Leffell MS, Loiseau P, Malkki M, Markiewicz M, Martinetti M, Maruya E, Mehra N, Oguz F, Oudshoorn M, Pereira N, Rani R, Sergeant R, Thomson J, Tran TH, Turpeinen H, Yang KL, Zunec R, Carrington M, Knijff PD, Goulmy E. (2007). Phenotype Frequencies of Autosomal Minor Histocompatibility Antigens Display Significant Differences among Populations. PLoS Genet 3(6): e103 doi:10.1371/journal.pgen.0030103. (if=9.543 (corresponding year), ci=cited by 57) 7. Kumar R, Goswami R, Agarwal S, Israni N, Singh S. K., Rani R. (2007). Association and interaction of the TNF-alpha gene with other pro and anti-inflammatory cytokine genes and HLA genes in type 1 diabetes patients from North India. Tissue Antigens 69: 557-567, doi:10.1111/j.1399-0039.2007.00817.x, 2007 (if=3.024 (corresponding year), ci=cited by 22) 8. Rani R, Fernandez-Viña MA, Stastny P.(1998). Associations between HLA class II alleles in a North Indian population. Tissue Antigens 52 (1), pp. 37-43 (if=4.339 (corresponding year), ci=cited by 43) 9. Rani R, Narayan R, Kar HK, Fernandez-vina MA, Stastny P. (1998) Role of HLA-B and C alleles in development of Psoriasis in patients from North India. Tissue Antigens 51 : 618-622. (if=4.339 (corresponding year), ci=cited by 31) 10. Rani R, Fernandez vina MA, Zaheer SA, Beena KR, Stastny P (1993). Study of HLA class II alleles by PCR Oligotyping in leprosy patients from North India. Tissue Antigens 42 : 133-137. (if=4.784 (corresponding year), ci=cited by 73)

435

SALUJA, DAMAN (b 1959), Professor and Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi-110007

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Daman Saluja, an outstanding teacher and researcher, has developed novel strategies of DNA based diagnosis of infectious diseases and leukemia. She has patented and transferred the technology for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhea, two important organisms causing sexually transmitted diseases for commercialization for which Prof Saluja received ‘Biotech Product & Process Development and Commercialization Award’ of 2013. She has also developed and patented beacon based diagnosis of Trichomonas vaginalis and LAMP based diagnosis of Mycobacterium tuberculosis (student received Ranbaxy award 2015). In collaboration with an Industry, a low cost hand-held fluorescence detector has been developed to reduce the cost of diagnostic assay. More recently, Dr Saluja’s laboratory has developed and evaluated novel method of molecular beacon based reverse transcriptase PCR method for specific detection and quantification of bcr/abl transcript for CML and AML patients. All these six diagnostic assays are in the process of technology transfer for commercialization by University. The anti-proliferative effect of esculetin on AML and other cancer cell-lines was deciphered (student received Sunpharma Award 2016). In addition to her contributions in diagnostic, she is also interested to understand the mechanism of gene regulation in cancer using Sin3B, a corepressor protein, as model system. They identified two new isoforms of hSin3B and showed their selective expression in oral carcinoma. Her pioneering work has established that Sin3B interacts with p53 under genotoxic and non-genotoxic stress and repress the target gene expression through selective hypermethylation. Proposer: Prof. B. C. Das, Seconder: Prof K Murlidhar Ten Best Publications: 1. Saluja, D., & Godson, G. N. (1995). Biochemical characterization of escherichia coli temperature- sensitive dnaB mutants dnaB8, dnaB252, dnaB70, dnaB43, and dnaB454. Journal of Bacteriology, 177(4), 1104-1111. (if=3.94, ci=26) 2. Tanese, N., Saluja, D., Vassallo, M. F., Chen, J. & Admon, A. (1996). Molecular cloning and analysis of two subunits of the human TFIID complex: HTAFII130 and hTAFII100. Proceedings of the National Academy of Sciences of the USA 93(24), 13611-13616. (if=10.45, ci=157) 3. Saluja, D., Vassallo, M. F., & Tanese, N. (1998). Distinct subdomains of human TAF(II)130 are required for interactions with glutamine-rich transcriptional activators. Molecular and Cellular Biology, 18(10), 5734-5743. (if=10.49, ci=129) 4. Chaudhry, U., Ray, K., Bala, M., & Saluja, D. (2002). Detection of a Novel Point Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sexually Transmitted Infections, 78(6), 440-444. (if=3.39, ci=23) 5. Mishra, A., Bharti, A. C., Varghese, P., Saluja, D., & Das, B. C. (2006). Differential expression and activation of NF-κB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection. in.J.of Cancer119(12), 2840-2850. (if=5.3, ci=93) 6. Patel, A. L., Sachdev, D., Nagpal, P., Chaudhry, U., Sonkar, S. C., Mendiratta, S. & Saluja, D. (2010). Prevalence of Chlamydia infection among ------chlamydia trachomatis. Annals of Clinical Microbiology and Antimicrobials:9:24-29 (if=3.27, ci=34) 7. Bansal, N., Kadam, R. Mittal, S. Vig,L., Sharma,R., Dwarakanath, B.S., Saluja, D. (2011). Tumor Suppressor Protein p53 Recruits Human Sin3B/HDAC1 Complex for Down-Regulation of Its Target Pr in Response to Genotoxic Stress PLoS One. 6(10): e26156. (if=4.41, ci=27) 8. Kadamb R, Mittal S, Bansal N, Batra H, Saluja D. (2013) Sin3: insight into its transcription regulatory functions. Eur J cell Biol. 2013 Aug- Sep; 92(8-9): 237 – 46. (if=3.82, ci=42) 9. Arora R, Sawney S, Saini V, Steffi C, Tiwari M, Saluja D (2016) Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Mol Cancer. 2016 Oct 18;15(1):64. (if=5.89, ci=yet to come) 10. Sonkar SC, Sachdev D, Mishra PK, Kumar A, Mittal P, Saluja D. (2016) A molecular-beacon-based asymmetric PCR assay for easy visualization of amplicons in the diagnosis of trichomoniasis. Biosens Bioelectron. 11;86:41-47. doi: 10.1016/j.bios.201 (if=7.44, ci=yet to come)

436

TRIPATHI, ANIL KUMAR (b 1958), Professsor and Head, Department of Clinical Hematology, K.G.Medical University, Lucknow

Member of the NASI: No (YON 2013, Medical & Forensic Sciences)

Dr. A.K. Tripathi has 130 research publications. He has done extensive research work in the field of Hematology, Cancer biology and HIV. His pioneering work, published in Journal of Immunology, led to newer understanding of monocyte FcR expression and mechanism of action of monoclonal antibodies in cancer and other diseases. He has shown, for the first time, that the S phase fraction and aneuploidy may be good prognostic markers in patients with chronic myeloid leukemia. Recently his work on the bone marrow changes in immune thrombocytopenia was widely appreciated. He has shown that besides nutritional factors, myelodysplasia is a common cause of anemia in HIV/AIDS patients. This aspect of pathogenesis has not previously been reported from India. He has mentored 5 PhD scholars. Dr. A. K. Tripathi has worked as visiting scientist at National Institutes of Health, USA. He has written a text book “Essentials of Medicine for Dental students” widely read all over India and neighbouring countries. He has been Editor- in-chief of an indexed journal “Indian J of Hematology & Blood Transfusion” published by Springer. He is Fellow of National Academy of Medical Sciences of India. Dr. Tripathi has received "Vigyan Gaurav" the highest award by the Government of UP for outstanding scientific contributions. He has received National Award from Department of Science & Technology, Govt. of India and Fellowship of Royal College of Physicians (London) in 2016. Proposer: Dr. S.S. Agarwal ( now deceased), Seconder: Dr. Shally Awasthi Ten Best Publications: 1. Tripathi AK, Taplits M, Puri J, and Hoffman T: Down-Regulation of Surface FcRI and Decrease in Antibody-Dependent Cellular Cytotoxicity of Cultured Monocytes: Reversal by Monensin or Cytochalasine-D. J. Immunology 1991: 146(4); 1309-1315. (if=4.92, ci=16) 2. Hoffman T, Tripathi AK, Lee YL, Lizzio EF, and Bonvini E: Stimulation of Human Monocytes by Anti- CD3 Monoclonal Antibody: Induction of Inflammatory mediator Release via Immobilization of Fc Receptor by Adsorbed Immunoglobulin and T-Lymphocytes. In (if=2.61, ci=8) 3. Hoffman T, Tripathi AK, Lee YL, Bonvini E, Golding B, and Saventer GV: Inflammatory Mediator Release from Human Monocytes via Immobilized Fc Receptor: Potential Role in Adverse Reactions to Systemic Monoclonal Antibody Therapy. Transplantation 199 (if=3.53, ci=11) 4. Hoffman T, Lee YL, Lizzio EF, Tripathi AK et al. Differential Turnover of enzymes involved in human monocytes eicosanoid metabolism. Selective inhibition of cyclooxygenase Product formation by cycloheximide in the absence of effects on 5-lipoxygen (if=5.09, ci=6) 5. Tripathi AK, Chaturvedi R, Ahmad R, Asim M, Sawlani KK, Singh RL, Tekwani BL. Peripheral Blood Leukocyte Ornithene Decarboxylase Activity in Chronic Myeloid Leukemia Patients: Prognostic and Therapeutic implications. Leukemia Research. 2002; 26: (if=2.35, ci=6) 6. Tripathi AK, Kalra P, Misra R, Gupta N. Study of Bone Marrow Abnormalities in Patients with HIV Disease. JAPI. 2005; 53: 105-111 (if=0.37, ci=24) 7. Bajpai P, Tripathi AK, Agarwal D. Genetic Polymorphism of CYP3A5 in Indian chronic myeloid leukemia patients. Mol Cell Biochem. 2010; 336: 49-54 (if=2.05, ci=18) 8. Tripathi AK, Misra S, Kumar A, Yadav D, Shukla A, Yadav Y. Megakaryocyte morphology and its impact in predicting response to steroid in immune thrombocytopenia. Platelets 2013; Nov 16 online DOI 10.3109/09537104.2013845875 (if=3.2, ci=7) 9. Jangamreddy JR, Panigrahi S, Lotfi K, Yadav M, Maddika S, Tripathi AK, Sanyal S, Los MJ. Mapping of Apoptin interaction with BCR-ABL 1, and development of apoptin based targeted therapy. Oncotarget 2014; 5:7196-7211 (if=5.008, ci=6) 10. Singh AK, Awasthi D, Dubey M, Nagarkoti S, Kumar A, Chandra T, Barthwal MK, Tripathi AK, Dixit M. High oxidative stress adversely affects NFB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chro (if=3.55, ci=1)

437