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(12) United States Patent (10) Patent No.: US 6,645,535 B2 Zyck Et Al

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(12) United States Patent (10) Patent No.: US 6,645,535 B2 Zyck Et Al USOO6645535B2 (12) United States Patent (10) Patent No.: US 6,645,535 B2 Zyck et al. (45) Date of Patent: *Nov. 11, 2003 (54) METHOD OF MAKING COATED CHEWING FR 2 635 441 2/1990 GUMPRODUCTS CONTAINING WARIOUS FR 2 706 771 6/1993 ANTACIDS GB O 934,596 8/1963 GB O 963 518 7/1964 GB 1489,832 10/1977 (75) Inventors: Daniel J. Zyck, North Riverside, IL GB 2181646 A 4/1987 (US); Michael J. Greenberg, IT O2173487 7/1997 Northbrook, IL (US); David G. IT O1293655 3/1999 Barkalow, Deerfield, IL (US); Scott W. JP 1991-112450 5/1991 Marske, LaGrange, IL (US); Philip G. JP 1991-251533 11/1991 Schnell, Downers Grove, IL (US); JP 1994-303911 11/1994 Philip Mazzone, Griffith, IN (US) JP 1996-19370 1/1996 JP 86/242561 10/1996 (73) Assignee: WM. Wrigley Jr. Company, Chicago, KR 94-2868 4/1994 WO WO 84/02271 6/1984 IL (US) WO WO 90/12511 11/1990 WO WO 90/12583 11/1990 (*) Notice: Subject to any disclaimer, the term of this WO WO 92/06680 4/1992 patent is extended or adjusted under 35 WO WO95/OOO38 1/1995 U.S.C. 154(b) by 53 days. WO WO95/OOO39 1/1995 WO WO95/10290 4/1995 This patent is Subject to a terminal dis WO WO 96/OOO70 1/1996 claimer. WO WO 96/03975 2/1996 WO WO 97/21424 6/1997 WO WO 97/24036 6/1997 (21) Appl. No.: 09/747,323 WO WO 98/231.65 6/1998 (22) Filed: Dec. 22, 2000 WO WO 98/23166 6/1998 WO WO 98/23167 6/1998 (65) Prior Publication Data WO WO 99/27798 6/1999 WO WO 99/33352 7/1999 US 2001/0021403 A1 Sep. 13, 2001 WO WO 99/44436 9/1999 WO WO OO/13523 3/2000 Related U.S. Application Data WO WOOO/35296 6/2000 WO WO OO/35298 6/2000 (63) Continuation-in-part of application No. 09/552,290, filed on WO WO OO/38532 7/2000 Apr. 19, 2000, which is a continuation of application No. WO WO O2/13781 A1 2/2002 09/389.211, filed on Sep. 2, 1999, now abandoned. (51) Int. Cl." .................................................. A23G 3/30 OTHER PUBLICATIONS (52) ... 426/5; 424/48; 424/440 Beckett, A. H. et al., “Buccal absorption of basis drugs and (58) Field of Search ........................... 426/3, 5; 424/48, its application as an in Vivo model of passive drug transfer 424/440 through lipid membranes”, J. Pharm. Pharmac., 19 Suppl. 1967, pp. 31S-41S. (56) References Cited David S. Weinberg et al. “Sublingual absorption of selected opioid analgesics”, Clin. Pharmacol Ther, 1998, vol. 44, pp. U.S. PATENT DOCUMENTS 335-342. 1298.670 A 4/1919 Cramer (List continued on next page.) 1,629,461 A 5/1927 Berg et al. 2,892,753 A 6/1959 Ludwig Schmidt et al. Primary Examiner Arthur L. Corbin 2.990,328 A 6/1961 Lincoln (74) Attorney, Agent, or Firm-Steven P. Shurtz; Brinks 3,011,949 A 12/1961 Bilotti Hofer Gilson & Lione 3,029,189 A 4/1962 Hardy et al. 3,047.461 A 7/1962 Hardy et al. (57) ABSTRACT 3.075,884 A 1/1963 Bilotti et al. 3,196,172 A 7/1965 Wright, Jr. et al. A method of making antacid coated chewing gum products 3,308,022 A 3/1967 Cummings et al. comprises the Steps of providing chewing gum cores, pro 3,498,964 A 3/1970 Hayashi Viding a coating Syrup comprising a bulk Sweetener and a 3,554,767 A 1/1971 Daum neutralizing antacid Suspended in the coating Syrup, the coating syrup containing from about 25% to about 50% by (List continued on next page.) weight of the Solids in the Syrup of a neutralizing antacid, FOREIGN PATENT DOCUMENTS Selected from the group consisting of aluminum Salts, bis muth Salts, magnesium Salts, Sodium bicarbonate, potassium DE 43 42 568 A1 6/1994 bicarbonate, potassium citrate, Sodium potassium tartrate, EP O 202 819 A2 11/1986 EP O 217 109 A2 4/1987 tricalcium phosphate and mixtures thereof, and applying the EP O 221 850 A2 5/1987 coating Syrup to the cores and drying the Syrup to produce EP O 239 541 A2 9/1987 a coating on the cores. Methods of use of the product to EP O 371584 A2 6/1990 provide relief in the gastrointestinal tract are also included. EP O 273 809 B1 7/1998 FR 2 345 938 10/1977 32 Claims, No Drawings US 6,645,535 B2 Page 2 3.590,057 6/1971 Suzuki et al. 5,182,099 1/1993 Jonsson et al. 3,845,217 10/1974 Ferno et al. 5,229,137 7/1993 Wolfe 3,877,468 4/1975 Lichtneckert et al. 5.244,670 9/1993 Upson et al. 3,901.248 8/1975 Lichtneckert et al. 5,284,657 2/1994 Lu et al. 3,995,064 11/1976 Ehrgott et al. 5,286,500 2/1994 Synosky et al. 4,154,814 5/1979 Hand et al. 5,294,433 3/1994 Singer et al. 4,238,475 12/1980 Witzel et al. 5,294,449 3/1994 Greenberg 4,238,510 12/1980 Cherukuri et al. 5,340,566 8/1994 Curtis et al. 4,250,195 2/1981 Cherukuri et al. 5,378,131 1/1995 Greenberg 4,283,408 8/1981 Hirata et al. 5,380,530 1/1995 Hill 4,317,838 3/1982 Cherukuri et al. 5,380,535 1/1995 Geyer et al. 4,374,858 2/1983 Glass et al. 5,397,580 3/1995 Song et al. 4,378,374 3/1983 Reggio et al. 5,410,028 4/1995 Asami et al. 4,386,063 5/1983 Boden 5,419,919 5/1995 Song et al. 4,386,106 5/1983 Merrit et al. 5,433,960 7/1995 Meyers 4400,372 8/1983 Muhker et al. 5,445,834 8/1995 Burger et al. 4,446,135 5/1984 Fountaine 5,455.286 10/1995 Amidon et al. 4,452,821 6/1984 Gergely 5,456.677 10/1995 Spector 4,459,311 7/1984 DeTora et al. 5,487.902 1/1996 Andersen et al. 4,474,749 10/1984 Kruppa 5.488.962 2/1996 Perfetti 4,512.968 4/1985 Komiyama et al. 5,494,685 2/1996 Tyrpin et al. 4,533,556 8/1985 Piccolo et al. 5,496.541 3/1996 Cutler 4,555.407 11/1985 Kramer et al. 5,512.306 4/1996 Carlsson et al. 4,563,345 1/1986 Arrick 5,523,097 6/1996 Song et al. 4,639,368 1/1987 Niazi et al. 5,534.272 7/1996 Bernstein 4,647,450 3/1987 Peters et al. 5,536,511 7/1996 Yatka 4,711,774 12/1987 Denick, Jr. et al. 5,543,160 8/1996 Song et al. 4,716,033 12/1987 Denick, Jr. 5,554,380 9/1996 Cuca et al. 4,737,366 4/1988 Gergely et al. 5,569.477 10/1996 Nesbitt 4,753,800 6/1988 Mozda 5,571,528 11/1996 Lee et al. 4.753805 6/1988 Cherukuri et al. 5,571.543 11/1996 Song et al. 4.755,389 7/1988 Jones et al. 5,576,344 11/1996 Sandler et al. 4,758,424 7/1988 Denick, Jr. et al. 5,580,590 12/1996 Hartman 4,822,597 4/1989 Faust et al. 5,582,855 12/1996 Cherukuri et al. 4,822.816 4/1989 Markham 5,585,110 12/1996 Kalili et al. 4,828.820 5/1989 Glass et al. 5,593.685 1/1997 Bye et al. 4,832,994 5/1989 Fey 5,601858 2/1997 Manshukhani 4,835,162 5/1989 Abood 5,605,698 2/1997 Ueno 4,849.227 7/1989 Cho 5,607,697 3/1997 Alkire et al. 4.853,212 8/1989 Faust et al. 5,618,517 4/1997 Miskewitz 4,867,989 9/1989 Silva et al. 5,628,986 5/1997 Sanker et al. 4.882,152 11/1989 Yang et al. 5,629,013 5/1997 Upson et al. 4,894,234 1/1990 Sharma et al. 5,629,026 5/1997 Davis 4,908.211 3/1990 PaZ 5,629,035 5/1997 Miskewitz 4,908.212 3/1990 Kwon et al. 5,645,853 7/1997 Winston et al. 4,929.447 5/1990 Yang 5,651987 7/1997 Fuisz 4929,508 5/1990 Sharma et al. 5,656,652 8/1997 Davis 4,933,184 6/1990 Tsuk 5,665,386 9/1997 Bebet et al. 4,935,242 6/1990 Sharma et al. 5,665,406 9/1997 Reed et al. 4,938.963 7/1990 Parnell 5,667.802 9/1997 Grimberg 4,944.949 7/1990 Story et al. 5,693,334 12/1997 Miskewitz 4963,369 10/1990 Song et al. 5,698.215 12/1997 Kalili et al. 4.968,511 11/1990 D'Amelia et al. 5,702.687 12/1997 Miskewitz 4968,716 11/1990 Markham 5,711,961 1/1998 Reiner et al. 4,971,079 11/1990 Talapin et al. 5,716,928 2/1998 Benet et al. 4,971,787 11/1990 Cherukuri et al. 5,736,175 4/1998 Cea et al. 4,975,270 12/1990 Kehoe 5,744,164 4/1998 Chauffard et al.
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