USOO6645535B2 (12) United States Patent (10) Patent No.: US 6,645,535 B2 Zyck et al. (45) Date of Patent: *Nov. 11, 2003 (54) METHOD OF MAKING COATED CHEWING FR 2 635 441 2/1990 GUMPRODUCTS CONTAINING WARIOUS FR 2 706 771 6/1993 ANTACIDS GB O 934,596 8/1963 GB O 963 518 7/1964 GB 1489,832 10/1977 (75) Inventors: Daniel J. Zyck, North Riverside, IL GB 2181646 A 4/1987 (US); Michael J. Greenberg, IT O2173487 7/1997 Northbrook, IL (US); David G. IT O1293655 3/1999 Barkalow, Deerfield, IL (US); Scott W. JP 1991-112450 5/1991 Marske, LaGrange, IL (US); Philip G. JP 1991-251533 11/1991 Schnell, Downers Grove, IL (US); JP 1994-303911 11/1994 Philip Mazzone, Griffith, IN (US) JP 1996-19370 1/1996 JP 86/242561 10/1996 (73) Assignee: WM. Wrigley Jr. Company, Chicago, KR 94-2868 4/1994 WO WO 84/02271 6/1984 IL (US) WO WO 90/12511 11/1990 WO WO 90/12583 11/1990 (*) Notice: Subject to any disclaimer, the term of this WO WO 92/06680 4/1992 patent is extended or adjusted under 35 WO WO95/OOO38 1/1995 U.S.C. 154(b) by 53 days. WO WO95/OOO39 1/1995 WO WO95/10290 4/1995 This patent is Subject to a terminal dis WO WO 96/OOO70 1/1996 claimer. WO WO 96/03975 2/1996 WO WO 97/21424 6/1997 WO WO 97/24036 6/1997 (21) Appl. No.: 09/747,323 WO WO 98/231.65 6/1998 (22) Filed: Dec. 22, 2000 WO WO 98/23166 6/1998 WO WO 98/23167 6/1998 (65) Prior Publication Data WO WO 99/27798 6/1999 WO WO 99/33352 7/1999 US 2001/0021403 A1 Sep. 13, 2001 WO WO 99/44436 9/1999 WO WO OO/13523 3/2000 Related U.S. Application Data WO WOOO/35296 6/2000 WO WO OO/35298 6/2000 (63) Continuation-in-part of application No. 09/552,290, filed on WO WO OO/38532 7/2000 Apr. 19, 2000, which is a continuation of application No. WO WO O2/13781 A1 2/2002 09/389.211, filed on Sep. 2, 1999, now abandoned. (51) Int. Cl." .................................................. A23G 3/30 OTHER PUBLICATIONS (52) ... 426/5; 424/48; 424/440 Beckett, A. H. et al., “Buccal absorption of basis drugs and (58) Field of Search ........................... 426/3, 5; 424/48, its application as an in Vivo model of passive drug transfer 424/440 through lipid membranes”, J. Pharm. Pharmac., 19 Suppl. 1967, pp. 31S-41S. (56) References Cited David S. Weinberg et al. “Sublingual absorption of selected opioid analgesics”, Clin. Pharmacol Ther, 1998, vol. 44, pp. U.S. PATENT DOCUMENTS 335-342. 1298.670 A 4/1919 Cramer (List continued on next page.) 1,629,461 A 5/1927 Berg et al. 2,892,753 A 6/1959 Ludwig Schmidt et al. Primary Examiner Arthur L. Corbin 2.990,328 A 6/1961 Lincoln (74) Attorney, Agent, or Firm-Steven P. Shurtz; Brinks 3,011,949 A 12/1961 Bilotti Hofer Gilson & Lione 3,029,189 A 4/1962 Hardy et al. 3,047.461 A 7/1962 Hardy et al. (57) ABSTRACT 3.075,884 A 1/1963 Bilotti et al. 3,196,172 A 7/1965 Wright, Jr. et al. A method of making antacid coated chewing gum products 3,308,022 A 3/1967 Cummings et al. comprises the Steps of providing chewing gum cores, pro 3,498,964 A 3/1970 Hayashi Viding a coating Syrup comprising a bulk Sweetener and a 3,554,767 A 1/1971 Daum neutralizing antacid Suspended in the coating Syrup, the coating syrup containing from about 25% to about 50% by (List continued on next page.) weight of the Solids in the Syrup of a neutralizing antacid, FOREIGN PATENT DOCUMENTS Selected from the group consisting of aluminum Salts, bis muth Salts, magnesium Salts, Sodium bicarbonate, potassium DE 43 42 568 A1 6/1994 bicarbonate, potassium citrate, Sodium potassium tartrate, EP O 202 819 A2 11/1986 EP O 217 109 A2 4/1987 tricalcium phosphate and mixtures thereof, and applying the EP O 221 850 A2 5/1987 coating Syrup to the cores and drying the Syrup to produce EP O 239 541 A2 9/1987 a coating on the cores. Methods of use of the product to EP O 371584 A2 6/1990 provide relief in the gastrointestinal tract are also included. 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