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Dialect and Local Media: Reproducing the Multi- Dialectal Hierarchical Space in Limburg (The Netherlands)
Dialect and local media: Reproducing the multi- dialectal hierarchical space in Limburg (the Netherlands) Leonie Cornips i, ii , Vincent de Rooij iii , Irene Stengs i ii and Lotte Thissen i Meertens Institute/The Royal Academy of Art and Sciences, Amsterdam; ii Maastricht University; iii University of Amsterdam The Netherlands 1 INTRODUCTION This chapter aims at contributing to an understanding of processes of language standardization by looking at a multidialectal public live performance, broadcast by local media in the Dutch province of Limburg. We will focus on this live perfor- mance, which involves a reading-aloud event of extracts from the fantasy book series Harry Potter . For this event, extracts were translated in written form into various Limburgian dialects. These translations obeyed the normative dialect or- thography acknowledged by the most important main actors in Limburg (see later). 2 The imposition of a normative spelling for dialects evidences processes of codifica- tion and implementation, two major stages in language standardization (cf. Deumert 2004, Haugen 2003, Milroy 2001). These ongoing processes in Limburg result in the standardization of multiple dialects that differ maximally from each other, espe- cially at the level of the lexicon. These processes also anchor the multiple dialects to place. Language standardization involves concern with form and function, and is based on as well as framed by ‘discursive projects’: Standardization is concerned with linguistic forms (corpus planning, i.e. selec- tion and codification) as well as the social and communicative functions of lan- guage (status planning, i.e. implementation and elaboration). In addition, stand- ard languages are also discursive projects, and standardization processes are typ- ically accompanied by the development of specific discourse practices. -
Expanding the Range of ZNF804A Variants Conferring Risk of Psychosis
Molecular Psychiatry (2011) 16, 59–66 & 2011 Macmillan Publishers Limited All rights reserved 1359-4184/11 www.nature.com/mp ORIGINAL ARTICLE Expanding the range of ZNF804A variants conferring risk of psychosis S Steinberg1, O Mors2, AD Børglum2,3, O Gustafsson1,4, T Werge5, PB Mortensen6, OA Andreassen4, E Sigurdsson7,8, TE Thorgeirsson1,YBo¨ttcher1, P Olason1, RA Ophoff9,10, S Cichon11, IH Gudjonsdottir1, OPH Pietila¨inen12,13, M Nyegaard3, A Tuulio-Henriksson14, A Ingason1, T Hansen5, L Athanasiu4, J Suvisaari14, J Lonnqvist14, T Paunio15, A Hartmann16,GJu¨rgens17, M Nordentoft18, D Hougaard19, B Norgaard-Pedersen20, R Breuer21, H-J Mo¨ller22, I Giegling16, B Glenthøj23, HB Rasmussen5, M Mattheisen10, I Bitter24,JMRe´thelyi24, T Sigmundsson7,8, R Fossdal1, U Thorsteinsdottir1,8, M Ruggeri25, S Tosato25, E Strengman9, GROUP37, LA Kiemeney26, I Melle4, S Djurovic27, L Abramova28, V Kaleda28, M Walshe29, E Bramon29, E Vassos29,30,TLi29,31, G Fraser32, N Walker33, T Toulopoulou29, J Yoon34, NB Freimer10, RM Cantor10,34, R Murray29, A Kong1, V Golimbet28,EGJo¨nsson35, L Terenius35, I Agartz35, H Petursson7,8,MMNo¨then36, M Rietschel21, L Peltonen12,13, D Rujescu16, DA Collier30,31, H Stefansson1, D St Clair32 and K Stefansson1,8 1deCODE genetics, Reykjavik, Iceland; 2Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark; 3Department of Human Genetics, Aarhus University, Arhus C, Denmark; 4Department of Psychiatry, Ulleva˚l University Hospital and Institute of Psychiatry, University of Oslo, Oslo, Norway; 5Research -
Monitoring and the FLONET/TRANS Model As Tools to Characterize the Nitrate Distribution and Transport in the Noor Catchment (The Netherlands)
Slovak Geol. Mag., 8, 2 (2002), 147-158 Monitoring and the FLONET/TRANS model as tools to characterize the nitrate distribution and transport in the Noor catchment (the Netherlands) JOZEF KordIk', Henny A.J. van Lanen2 and ROEL DUKSMA2 'Geological Survey of Slovak Republic, Mlynska dolina 1, 817 04 Bratislava, Slovakia 2Wageningen University, De Nieuwlanden 11, Wageningen, the Netherlands Abstract. Intensive human activities, such as agricultural practices, groundwater abstraction or land use changes, have had a negative impact on the state of the natural environment in The Netherlands. The in- creased inputs of fertilisers and animal manure after 1950 have boosted crop production to a high level, but have also contributed to increased nitrogen emissions from agriculture to groundwater, surface waters and atmosphere. Since 1991, a comprehensive hydrological and hydrogeological research project has been started in the Noor (chalk) catchment situated on the Dutch-Belgian boundary due to situation has become critical in this region. The investigation covers analysis of the hydrogeological system of the Noor catchment, including the relationship between recharge, groundwater heads, springflow, streamflow and chemical composition of water. The monitoring shows that groundwater under the plateau is heavily polluted (often N03" concentra- tions > 100 mg.l"1). Springs also have high N03" contents (mean: 64 mg.!"') because they are fed by this groundwater. Groundwater under the wet valley is less polluted (mean: 27 mg.l"1) due to denitrification and being old, unpolluted water. Water in the Noor brook and its tributaries is coming from the polluted springs and from seepage areas in the wet valley that drain the less polluted groundwater there. -
Software for Taxon-Aware Analysis of Clustered Protein Sequences
G3: Genes|Genomes|Genetics Early Online, published on September 2, 2017 as doi:10.1534/g3.117.300233 INVESTIGATIONS KinFin: Software for taxon-aware analysis of clustered protein sequences Dominik R. Laetsch∗,†,1 and Mark L. Blaxter∗ ∗Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT UK, †The James Hutton Institute, Errol Road, Dundee DD2 5DA UK ABSTRACT The field of comparative genomics is concerned with the study of similarities and differences KEYWORDS between the information encoded in the genomes of organisms. A common approach is to define gene bioinformatics families by clustering protein sequences based on sequence similarity, and analyse protein cluster presence protein orthology and absence in different species groups as a guide to biology. Due to the high dimensionality of these data, protein family downstream analysis of protein clusters inferred from large numbers of species, or species with many genes, evolution is non-trivial, and few solutions exist for transparent, reproducible and customisable analyses. We present comparative KinFin, a streamlined software solution capable of integrating data from common file formats and delivering genomics aggregative annotation of protein clusters. KinFin delivers analyses based on systematic taxonomy of the filarial nema- species analysed, or on user-defined groupings of taxa, for example sets based on attributes such as life todes history traits, organismal phenotypes, or competing phylogenetic hypotheses. Results are reported through graphical and detailed text output files. We illustrate the utility of the KinFin pipeline by addressing questions regarding the biology of filarial nematodes, which include parasites of veterinary and medical importance. We resolve the phylogenetic relationships between the species and explore functional annotation of proteins in clusters in key lineages and between custom taxon sets, identifying gene families of interest. -
Extracellular Onchocerca-Derived Small Rnas in Host Nodules
Edinburgh Research Explorer Extracellular Onchocerca -derived small RNAs in host nodules and blood Citation for published version: Quintana, JF, Makepeace, BL, Babayan, SA, Ivens, A, Pfarr, KM, Blaxter, M, Debrah, A, Wanji, S, Ngangyung, HF, Bah, GS, Tanya, VN, Taylor, DW, Hoerauf, A & Buck, AH 2015, 'Extracellular Onchocerca -derived small RNAs in host nodules and blood', Parasites and Vectors, vol. 8, no. 1, 58. https://doi.org/10.1186/s13071-015-0656-1 Digital Object Identifier (DOI): 10.1186/s13071-015-0656-1 Link: Link to publication record in Edinburgh Research Explorer Document Version: Publisher's PDF, also known as Version of record Published In: Parasites and Vectors Publisher Rights Statement: © 2015 Quintana et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. -
Second Case of Zoonotic Onchocerca Infection in a Resident of Oita in Japan
Article available at http://www.parasite-journal.org or http://dx.doi.org/10.1051/parasite/1996032179 S e c o n d c a s e o f z o o n o t ic O n c h o c e r c a in f e c t io n IN A RESIDENT OF OlTA IN JAPAN TAKAOKA H.*, BAIN O.**, TAJIMI S.***, KASHIMA K.****, NAKAYAMA I.****, KORENAGA M.*****, AOKI C.* & OTSUKA Y.* Summary : Résumé : D euxièm e cas d ’infection d ’un habitant d ’O ïta , au A non-gravid female Onchocerca was found in histopathological J apon, par une onchocerque animale sections of a biopsy specimen taken from a painful nodule in the A Oïta, au sud du Japon, une femme consulte pour un nodule wrist of a 57-year-old woman in Oita, in southern Japan. Six sous-cutané douloureux au poignet accompagné d'une paralysie species of Onchocerca have been found in animals in Japan: two récente de la main. Une onchocerque femelle, non gravide, est in wild bovids, one in equids, and three in domestic bovids of trouvée sur les coupes histologiques de la biopsie. which one, Onchocerca sp., is only known by the microfilaria and Six espèces d'onchocerques sont signalées au Japon: deux chez infective stage. Distinctive morphological features of the worm, un bovidé sauvage en montagne, une chez les chevaux, trois including a three-layered thick cuticle with prominent annular chez les bovins domestiques dont une, Onchocerca sp., connue ridges at wide intervals, high somatic muscles and narrow lateral seulement par la microfilaire et le stade infectant. -
Onchodermatitis: Where Are We Now?
Tropical Medicine and Infectious Disease Review Onchodermatitis: Where Are We Now? Michele E. Murdoch Department of Dermatology, West Herts Hospitals NHS Trust, Vicarage Road, Watford, Hertfordshire WD18 0HB, UK; [email protected]; Tel.: +44-1923-217139 Received: 30 July 2018; Accepted: 28 August 2018; Published: 1 September 2018 Abstract: Onchocerciasis causes debilitating pruritus and rashes as well as visual impairment and blindness. Prior to control measures, eye disease was particularly prominent in savanna areas of sub-Saharan Africa whilst skin disease was more common across rainforest regions of tropical Africa. Mass drug distribution with ivermectin is changing the global scene of onchocerciasis. There has been successful progressive elimination in Central and Southern American countries and the World Health Organization has set a target for elimination in Africa of 2025. This literature review was conducted to examine progress regarding onchocercal skin disease. PubMed searches were performed using keywords ‘onchocerciasis’, ‘onchodermatitis’ and ‘onchocercal skin disease’ over the past eight years. Articles in English, or with an English abstract, were assessed for relevance, including any pertinent references within the articles. Recent progress in awareness of, understanding and treatment of onchocercal skin disease is reviewed with particular emphasis on publications within the past five years. The global burden of onchodermatitis is progressively reducing and is no longer seen in children in many formerly endemic foci. Keywords: onchodermatitis; onchocercal skin disease; onchocerciasis; ivermectin 1. Introduction Onchocerciasis, caused by infection with the filarial worm Onchocerca volvulus, is one of the eleven neglected tropical diseases (NTDs) recently targeted for elimination by the World Health Organization (WHO) [1]. -
Development of a Confirmatory PCR Assay to Detect Onchocerca Volvulus in Pools of Vector Black Flies Alex Jeanne Talsma University of South Florida, [email protected]
University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School January 2013 Development of a Confirmatory PCR Assay to Detect Onchocerca volvulus in Pools of Vector Black Flies Alex Jeanne Talsma University of South Florida, [email protected] Follow this and additional works at: http://scholarcommons.usf.edu/etd Part of the Public Health Commons Scholar Commons Citation Talsma, Alex Jeanne, "Development of a Confirmatory PCR Assay to Detect Onchocerca volvulus in Pools of Vector Black Flies" (2013). Graduate Theses and Dissertations. http://scholarcommons.usf.edu/etd/4952 This Thesis is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. Development of a Confirmatory PCR Assay to Detect Onchocerca volvulus in Pools of Vector Black Flies by Alexandra J. Talsma A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science Department of Global Health College of Public Health University of South Florida Major Professor: Thomas Unnasch, Ph.D Alberto van Olphen, Ph.D, D.V.M. Canhui Liu, Ph.D Date of Approval November 4, 2013 Keywords: DNA Purification, Mitochondrion, Onchocerciasis, Streptavidin, Capture Assay Copyright © 2013, Alexandra J. Talsma DEDICATION I dedicate this thesis to my parents, Mr. and Mrs. Talsma, who have helped me throughout the years. You both have taught me many life lessons such as drive and discipline. I would like to thank you for your unconditional support and love. -
Altenbroek: Een Natuurreservaat in De Dalen Van Noor En Voer
NATUURHISTORISCH MAANDBLAD DECEMBER 2015 JAARGANG 104 | 12 231 Altenbroek: een natuurreservaat in Joost Dewyspelaere de dalen van Noor en Voer & Rik Palmans Nederlandse natuurliefhebbers kennen het Noordal (een door na de aankoop plannen om ter hoogte van Kattenroth de afschei - Natuurmonumenten beheerd reservaat in Noorbeek) als een ding tussen het gebied van Natuurmonumenten en dat van bijzonder waardevol gebied. Aan de andere kant van de lands - Natuurpunt weg te nemen. Runderen zouden dan ongehinderd de grens kunnen oversteken. Op de weg die ter hoogte van die grens grens sluit daar een natuurreservaat op aan waar sinds twintig loopt, zouden veeroosters het ontsnappen van de runderen moe - jaar hard wordt gewerkt aan de verhoging van de ecologische ten verhinderen. Het toenmalige gemeentebestuur van Voeren weigerde echter daar toestemming voor te geven. Later opteerden waarde. de Nederlanders voor Glan-runderen, terwijl de Belgen Galloway’s In 1995 verkochten de toenmalige eigenaren het historische land - kozen. De twee gebieden bleven dus netjes gescheiden. goed Altenbroek in ’s-Gravenvoeren (B). Het kasteel en het park bleven ook na de verkoop in particulier bezit. Natuurverenigingen Gericht habitatherstel in de vallei van de Noor verwierven de aan landbouwers verpachte weilanden, akkers en Gedurende de eerste tien jaren bestond het beheer vooral in het bossen – in totaal meer dan 150 ha. Ongeveer 25 ha ging naar de ‘vernatuurlijken’ van het landschap: 40 ha akkers en 18 ha aan - Nederlandse Natuurmonumenten; 130 ha werd eigendom van het plantingen van sparren, lorken en populieren werden omgevormd Vlaamse Natuurpunt. Het gebied sluit aan bij natuurgebied Noor - naar grasland en/of natuurlijk bos. -
Zoonotic Implications of Onchocerca Species on Human Health
pathogens Review Zoonotic Implications of Onchocerca Species on Human Health Maria Cambra-Pellejà 1,2, Javier Gandasegui 3 , Rafael Balaña-Fouce 4 , José Muñoz 3 and María Martínez-Valladares 1,2,* 1 Instituto de Ganadería de Montaña (CSIC-Universidad de León), 24346 León, Spain; [email protected] 2 Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, 24071 León, Spain 3 Instituto de Salud Global de Barcelona (ISGlobal), 08036 Barcelona, Spain; [email protected] (J.G.); [email protected] (J.M.) 4 Departmento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, 24071 León, Spain; [email protected] * Correspondence: [email protected] Received: 31 July 2020; Accepted: 15 September 2020; Published: 17 September 2020 Abstract: The genus Onchocerca includes several species associated with ungulates as hosts, although some have been identified in canids, felids, and humans. Onchocerca species have a wide geographical distribution, and the disease they produce, onchocerciasis, is generally seen in adult individuals because of its large prepatency period. In recent years, Onchocerca species infecting animals have been found as subcutaneous nodules or invading the ocular tissues of humans; the species involved are O. lupi, O. dewittei japonica, O. jakutensis, O. gutturosa, and O. cervicalis. These findings generally involve immature adult female worms, with no evidence of being fertile. However, a few cases with fertile O. lupi, O. dewittei japonica, and O. jakutensis worms have been identified recently in humans. These are relevant because they indicate that the parasite’s life cycle was completed in the new host—humans. In this work, we discuss the establishment of zoonotic Onchocerca infections in humans, and the possibility of these infections to produce symptoms similar to human onchocerciasis, such as dermatitis, ocular damage, and epilepsy. -
Extracellular Onchocerca-Derived Small Rnas in Host
Quintana et al. Parasites & Vectors (2015) 8:58 DOI 10.1186/s13071-015-0656-1 RESEARCH Open Access Extracellular Onchocerca-derived small RNAs in host nodules and blood Juan F Quintana1, Benjamin L Makepeace2, Simon A Babayan3, Alasdair Ivens1, Kenneth M Pfarr4, Mark Blaxter1, Alexander Debrah5, Samuel Wanji6, Henrietta F Ngangyung7, Germanus S Bah7, Vincent N Tanya8, David W Taylor2,9, Achim Hoerauf4 and Amy H Buck1* Abstract Background: microRNAs (miRNAs), a class of short, non-coding RNA can be found in a highly stable, cell-free form in mammalian body fluids. Specific miRNAs are secreted by parasitic nematodes in exosomes and have been detected in the serum of murine and dog hosts infected with the filarial nematodes Litomosoides sigmodontis and Dirofilaria immitis, respectively. Here we identify extracellular, parasite-derived small RNAs associated with Onchocerca species infecting cattle and humans. Methods: Small RNA libraries were prepared from total RNA extracted from the nodule fluid of cattle infected with Onchocerca ochengi as well as serum and plasma from humans infected with Onchocerca volvulus in Cameroon and Ghana. Parasite-derived miRNAs were identified based on the criteria that sequences unambiguously map to hairpin structures in Onchocerca genomes, do not align to the human genome and are not present in European control serum. Results: A total of 62 mature miRNAs from 52 distinct pre-miRNA candidates were identified in nodule fluid from cattle infected with O. ochengi of which 59 are identical in the genome of the human parasite O. volvulus. Six of the extracellular miRNAs were also identified in sequencing analyses of serum and plasma from humans infected with O. -
Onchocerciasis in the Orbital Region: an Unexpected Guest from Tropics
CASE REPORT Onchocerciasis in the Orbital Region: An Unexpected Guest From Tropics Pruthvi R Shivalingaiah1 , Prashanth Veerabhadraiah2 , Praveen Kumar3 , Nagaraj T Mayappa4 , Madhu R Jeyasekar5 ABSTRACT Background: Onchocerciasis is the world’s second commonest infectious cause of blindness. It is transmitted by the bite of the Simulium blackfly, which transmits the infective-stage larva into the human skin and mainly affects the people in the rural areas of Sub-Saharan Africa, Yemen, and those living in parts of Central and South Africa. The first case of ocular onchocerciasis in India was a woman from rural Assam, northeastern India reported in 2011. Here we report a rare case of onchocerciasis—a patient from a non-endemic region of Bengaluru, India, showing a swelling in the orbital region. Case description: A 55-year-old women was presented to our outpatient department with the complaints of a swelling below the left eyebrow since 2 months and drooping of the left upper eyelid since 1 month. The patient underwent excision of the swelling after CT and FNAC of the swelling. The worm in the wall of the excised cyst was identified as Onchocerca volvulus, on the basis of morphological features observed in histopathology. The patient was treated with a single oral dose of Ivermectin (150 μg/kg), and on follow-up at 4 months, she has not shown any recurrence of symptoms or fresh complaints. Conclusion: Onchocerciasis, though rare, can be a differential diagnosis of a subcutaneous swelling in the body. Clinical significance: Knowledge and awareness regarding the presence of this filarial worm in India is required, as it is rare and reporting of further cases needs to be done.