Common Reactive Chemicals
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Indiana State University ISU Laboratory Safety Guideline
ISU Laboratory Safety Guideline Working with Organic Peroxides and Storage Guidelines Date: December 2012 Indiana State University Organic peroxide is a compound containing the -O-O- structure and is considered a structural derivative of hydrogen peroxide. Organic peroxides are one of the most hazardous materials handled in the laboratory. These peroxides are low powered explosives that are sensitive to shock, sparks or other accidental ignition due to the weak –O-O bond. Organic compounds such as ethers can react with oxygen to form unstable peroxides. Peroxide formation can also occur under normal storage conditions when compounds become concentrated by evaporation or when mixed with other compounds. Types of Compounds known to form peroxides : Ethers containing primary and secondary alkyl groups (never distill an ether before it has been shown to be free of peroxide) Compounds containing benzylic hydrogens Compounds containing allylic hydrogens (C=C-CH) Compounds containing a tertiary C-H group (e.g., decalin and 2,5-dimethlyhexane) Compounds containing conjugated, polyunsaturated alkenes and alkynes (e.g., 1,3-butadiene, vinyl acetylene) Compounds containing secondary or tertiary C-H groups adjacent to an amide (e.g., 1-methyl-2- pyrrolidinone Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards, Updated Version General Procedures for working with Peroxide-forming chemicals: • Be aware of the use of peroxide-forming chemicals when designing or conducting a new experiment. • If possible, purchase material containing an inhibitor such as butylated hydroxytoluene (BHT). • Date the container when received, opened and tested. • Consult Prudent Practices or other resources for storage shelf-life and testing procedures. -
Peroxide-Forming Chemicals
Peroxide-Forming Chemicals 4 Ways to stop explosions, injuries, and added expenses: 1) Track shelf life A) label when tested and when to retest B) date when received 2) Handle with proper personal protective equipment A) gloves B) googles/safety glasses C) flame-resistant lab coat D) training E) Ask [the Dept. of Chemistry and Dept. of Environmental Health & Safety] for help 3) Store properly A) flammable storage cabinet if applicable B) avoid i) heat (keep in a cool place) ii) impact iii) friction iv) light (keep in a dark place) 4) Buy the right amount A) based on what will be used B) reduce the disposal of any un-used material (Dubiel). The Department of Chemistry wants you to learn from our experiences. Amides, Dioxane, Ethers, secondary alcohols, and Tetrahydrofuran (as well as other cyclic ethers) must be checked for peroxides. The University of Pittsburgh Department of Environmental Health and Safety (EH&S) recommends that all peroxide-forming chemicals should be tested every six months for peroxide content, and any chemicals that test positive should either be purified before use to remove the peroxide or discarded as chemical waste and replaced with fresh material. (http://www.ehs.pitt.edu/assets/docs/peroxide-forming.pdf). Ken Migliorese, a previous staff member, emailed the Department of Chemistry to remind us of the importance of doing peroxide testing on a regular basis. The need to test for peroxides was made clear to us by a series of unfortunate explosions which occurred in the undergraduate organic teaching labs in 2008. We had multiple defective layers of protection that caused failures of safety measures and three catastrophic errors (Reason). -
Peroxide Forming Chemicals
What are organic peroxides? Organic peroxides are a class of compounds that have unusual stability problems that make them among the most hazardous substances found in the laboratory. The lack of stability is due to the presence of an oxidation and reduction center within the same molecule. R-O-O-R R = organic side chains O-O = Peroxo bridge As a class, organic peroxides are considered to be powerful explosives and are sensitive to heat, friction, impact, light, as well as to strong oxidizing and reducing agents. Peroxide formers react with oxygen even at low concentrations to form peroxy compounds. Autoxidation of organic material proceeds by a free-radical chain mechanism and commonly affects organic solvents. R-H R- R-O-O R-O-O-R (In the presence of oxygen) The instability of the molecule (R-O-O-R) can cause auto-decomposition simply by bumping or jarring the container, addition of heat, light, or opening the cap. The risk associated with the peroxide increases if the peroxide crystallizes or becomes concentrated by evaporation or distillation. Peroxide crystals may form on the container plug or the threads of the cap and detonate as a result of twisting the lid. Classes of Peroxide Formers Aldehydes Ethers - especially cyclic ethers and those containing primary and secondary alcohol groups Compounds containing benzylic hydrogen atoms (particularly if the hydrogens are on tertiary carbon atoms) Compounds containing the allylic structure, including most alkenes. Vinyl and vinylidene compounds. Preventing Formation of Organic Peroxides No single method of inhibition of peroxide formation is suitable for all peroxide formers. -
Chemical Chemical Hazard and Compatibility Information
Chemical Chemical Hazard and Compatibility Information Acetic Acid HAZARDS & STORAGE: Corrosive and combustible liquid. Serious health hazard. Reacts with oxidizing and alkali materials. Keep above freezing point (62 degrees F) to avoid rupture of carboys and glass containers.. INCOMPATIBILITIES: 2-amino-ethanol, Acetaldehyde, Acetic anhydride, Acids, Alcohol, Amines, 2-Amino-ethanol, Ammonia, Ammonium nitrate, 5-Azidotetrazole, Bases, Bromine pentafluoride, Caustics (strong), Chlorosulfonic acid, Chromic Acid, Chromium trioxide, Chlorine trifluoride, Ethylene imine, Ethylene glycol, Ethylene diamine, Hydrogen cyanide, Hydrogen peroxide, Hydrogen sulfide, Hydroxyl compounds, Ketones, Nitric Acid, Oleum, Oxidizers (strong), P(OCN)3, Perchloric acid, Permanganates, Peroxides, Phenols, Phosphorus isocyanate, Phosphorus trichloride, Potassium hydroxide, Potassium permanganate, Potassium-tert-butoxide, Sodium hydroxide, Sodium peroxide, Sulfuric acid, n-Xylene. Acetone HAZARDS & STORAGE: Store in a cool, dry, well ventilated place. INCOMPATIBILITIES: Acids, Bromine trifluoride, Bromine, Bromoform, Carbon, Chloroform, Chromium oxide, Chromium trioxide, Chromyl chloride, Dioxygen difluoride, Fluorine oxide, Hydrogen peroxide, 2-Methyl-1,2-butadiene, NaOBr, Nitric acid, Nitrosyl chloride, Nitrosyl perchlorate, Nitryl perchlorate, NOCl, Oxidizing materials, Permonosulfuric acid, Peroxomonosulfuric acid, Potassium-tert-butoxide, Sulfur dichloride, Sulfuric acid, thio-Diglycol, Thiotrithiazyl perchlorate, Trichloromelamine, 2,4,6-Trichloro-1,3,5-triazine -
Hazardous Material Inventory Statement
City of Brooklyn Park FIRE DEPARTMENT 5200 - 85th Avenue North Brooklyn Park MN 55443 Phone: (763)493-8020 Fax: (763) 493-8391 Hazardous Materials Inventory Statement Users Guide A separate inventory statement shall be provided for each building. An amended inventory statement shall be provided within 30 days of the storage of any hazardous materials or plastics that changes or adds a hazard class or which is sufficient in quantity to cause an increase in the quantity which exceeds 5 percent for any hazard class. The hazardous materials inventory statement shall list by hazard class categories. Each grouping shall provide the following information for each hazardous material listed for that group including a total quantity for each group of hazard class. 1. Hazard class. (See attached Hazardous Materials Categories Listing) 2. Common or trade name. 3. Chemical Abstract Service Number (CAS number) found in 29 Code of Federal Regulations (C.F.R.). 4. Whether the material is pure or a mixture, and whether the material is a solid, liquid or gas 5. Maximum aggregate quantity stored at any one time. 6. Maximum aggregate quantity In-Use (Open to atmosphere) at any one time. 7. Maximum aggregate quantity In-Use (Closed to atmosphere) at any one time. 8. Storage conditions related to the storage type, high-pile, encapsulated, non-encapsulated. Attached is a listing of categories that all materials need to be organized to. Definitions of these categories are also attached for your use. At the end of this packet are blank forms for completing this project. For questions regarding Hazardous Materials Inventory Statement contact the Fire Department at 763-493-8020. -
Organic Peroxide and OH Formation in Aerosol and Cloud Water
Discussion Paper | Discussion Paper | Discussion Paper | Discussion Paper | Atmos. Chem. Phys. Discuss., 15, 17367–17396, 2015 www.atmos-chem-phys-discuss.net/15/17367/2015/ doi:10.5194/acpd-15-17367-2015 ACPD © Author(s) 2015. CC Attribution 3.0 License. 15, 17367–17396, 2015 This discussion paper is/has been under review for the journal Atmospheric Chemistry Organic peroxide and and Physics (ACP). Please refer to the corresponding final paper in ACP if available. OH formation in aerosol and cloud Organic peroxide and OH formation in water aerosol and cloud water: laboratory Y. B. Lim and B. J. Turpin evidence for this aqueous chemistry Title Page Y. B. Lim and B. J. Turpin Abstract Introduction Department of Environmental Sciences, Rutgers University, New Brunswick, NJ 08901, USA Conclusions References Received: 29 May 2015 – Accepted: 01 June 2015 – Published: 25 June 2015 Tables Figures Correspondence to: Y. B. Lim ([email protected]) J I Published by Copernicus Publications on behalf of the European Geosciences Union. J I Back Close Full Screen / Esc Printer-friendly Version Interactive Discussion 17367 Discussion Paper | Discussion Paper | Discussion Paper | Discussion Paper | Abstract ACPD Aqueous chemistry in atmospheric waters (e.g., cloud droplets or wet aerosols) is well 15, 17367–17396, 2015 accepted as an atmospheric pathway to produce secondary organic aerosol (SOAaq). Water-soluble organic compounds with small carbon numbers (C2-C3) are precursors 5 for SOAaq and products include organic acids, organic sulfates, and high molecular Organic peroxide and weight compounds/oligomers. Fenton reactions and the uptake of gas-phase OH rad- OH formation in icals are considered to be the major oxidant sources for aqueous organic chemistry. -
Potentially Explosive Chemicals*
Potentially Explosive Chemicals* Chemical Name CAS # Not 1,1’-Diazoaminonaphthalene Assigned 1,1-Dinitroethane 000600-40-8 1,2,4-Butanetriol trinitrate 006659-60-5 1,2-Diazidoethane 000629-13-0 1,3,5-trimethyl-2,4,6-trinitrobenzene 000602-96-0 1,3-Diazopropane 005239-06-5 Not 1,3-Dinitro-4,5-dinitrosobenzene Assigned Not 1,3-dinitro-5,5-dimethyl hydantoin Assigned Not 1,4-Dinitro-1,1,4,4-tetramethylolbutanetetranitrate Assigned Not 1,7-Octadiene-3,5-Diyne-1,8-Dimethoxy-9-Octadecynoic acid Assigned 1,8 –dihydroxy 2,4,5,7-tetranitroanthraquinone 000517-92-0 Not 1,9-Dinitroxy pentamethylene-2,4,6,8-tetramine Assigned 1-Bromo-3-nitrobenzene 000585-79-5 Not 2,2',4,4',6,6'-Hexanitro-3,3'-dihydroxyazobenzene Assigned 2,2-di-(4,4,-di-tert-butylperoxycyclohexyl)propane 001705-60-8 2,2-Dinitrostilbene 006275-02-1 2,3,4,6- tetranitrophenol 000641-16-7 Not 2,3,4,6-tetranitrophenyl methyl nitramine Assigned Not 2,3,4,6-tetranitrophenyl nitramine Assigned Not 2,3,5,6- tetranitroso nitrobenzene Assigned Not 2,3,5,6- tetranitroso-1,4-dinitrobenzene Assigned 2,4,6-Trinitro-1,3,5-triazo benzene 029306-57-8 Not 2,4,6-trinitro-1,3-diazabenzene Assigned Not 2,4,6-Trinitrophenyl trimethylol methyl nitramine trinitrate Assigned Not 2,4,6-Trinitroso-3-methyl nitraminoanisole Assigned 2,4-Dinitro-1,3,5-trimethyl-benzene 000608-50-4 2,4-Dinitrophenylhydrazine 000119-26-6 2,4-Dinitroresorcinol 000519-44-8 2,5-dimethyl-2,5-diydroperoxy hexane 2-Nitro-2-methylpropanol nitrate 024884-69-3 3,5-Dinitrosalicylic acid 000609-99-4 Not 3-Azido-1,2-propylene glycol dinitrate -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
Prediction of the Crystalline Densities of Aliphatic Nitrates by Quantum Chemistry Methods
Central European Journal of Energetic Materials ISSN 1733-7178; e-ISSN 2353-1843 Copyright © 2019 Sieć Badawcza Łukasiewicz – Institute of Industrial Organic Chemistry, Poland Cent. Eur. J. Energ. Mater. 2019, 16(3): 412-432; DOI 10.22211/cejem/112306 Article is available in PDF-format, in colour, at: http://www.wydawnictwa.ipo.waw.pl/cejem/Vol-16-Number3-2019/CEJEM_00978.pdf Article is available under the Creative Commons Attribution-Noncommercial-NoDerivs 3.0 license CC BY-NC-ND 3.0. Research paper Prediction of the Crystalline Densities of Aliphatic Nitrates by Quantum Chemistry Methods Guixiang Wang,* Yimin Xu, Chuang Xue, Zhiyuan Ding, Yan Liu, Hui Liu, Xuedong Gong** Computation Institute for Molecules and Materials, Department of Chemistry, Nanjing University of Science and Technology, Nanjing 210094, China E-mails: * [email protected]; ** [email protected] Abstract: Crystal density is a basic and important parameter for predicting the detonation performance of explosives, and nitrate esters are a type of compound widely used in the military context. In this study, thirty-one aliphatic nitrates were investigated using the density functional theory method (B3LYP) in combination with six basis sets (3-21G, 6-31G, 6-31G*, 6-31G**, 6-311G* and 6-31+G**) and the semiempirical molecular orbital method (PM3). Based on the geometric optimizations at various theoretical levels, the molecular volumes and densities were calculated. Compared with the available experimental data, the densities calculated by various methods are all overestimated, and the errors of the PM3 and B3LYP/3-21G methods are larger than those of other methods. Considering the results and the computer resources required by the calculations, the B3LYP/6-31G* method is recommended for predicting the crystalline densities of organic nitrates using a fitting equation. -
Addition Reactions and Photoisomerization of Cis,Trans-1,5-Cyclodecadiene
Louisiana State University LSU Digital Commons LSU Historical Dissertations and Theses Graduate School 1970 Addition Reactions and Photoisomerization of Cis,trans-1,5-Cyclodecadiene. Hsin-hsiong Hsieh Louisiana State University and Agricultural & Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_disstheses Recommended Citation Hsieh, Hsin-hsiong, "Addition Reactions and Photoisomerization of Cis,trans-1,5-Cyclodecadiene." (1970). LSU Historical Dissertations and Theses. 1859. https://digitalcommons.lsu.edu/gradschool_disstheses/1859 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Historical Dissertations and Theses by an authorized administrator of LSU Digital Commons. For more information, please contact [email protected]. 71-6579 HSIEH, Hsin-Hsiong, 1936- ADDITION REACTIONS AND PHOTOISOMERIZATION OF CIS,TRANS-1,5-CYCLODECADIENE. The Louisiana State University and Agricultural and Mechanical College, Ph.D., 1970 Chemistry, organic University Microfilms, Inc., Ann Arbor, Michigan ADDITION REACTIONS AND PHOTOISOMERIZATION OF CIS,TRANS-1,5“CYCLODECADIENE A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Department of Chemistry by Hsin-Hsiong Hsieh B.S., Taiwan Provincial Chung-Hsing University, i960 M.S., Louisiana State University, -
Compositions Comprising Nebivolol
(19) TZZ ZZ__T (11) EP 2 808 015 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 03.12.2014 Bulletin 2014/49 A61K 31/34 (2006.01) A61K 31/502 (2006.01) A61K 31/353 (2006.01) A61P 9/00 (2006.01) (21) Application number: 14002458.9 (22) Date of filing: 16.11.2005 (84) Designated Contracting States: • O’Donnell, John AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Morgantown, WV 26505 (US) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI • Bottini, Peter Bruce SK TR Morgantown, WV 26505 (US) • Mason, Preston (30) Priority: 31.05.2005 US 141235 Morgantown, WV 26504 (US) 10.11.2005 US 272562 • Shaw, Andrew Preston 15.11.2005 US 273992 Morgantown, WV 26504 (US) (62) Document number(s) of the earlier application(s) in (74) Representative: Samson & Partner accordance with Art. 76 EPC: Widenmayerstraße 5 09015249.7 / 2 174 658 80538 München (DE) 05848185.4 / 1 890 691 Remarks: (71) Applicant: MYLAN LABORATORIES, INC This application was filed on 16-07-2014 as a Morgantown, NV 26504 (US) divisional application to the application mentioned under INID code 62. (72) Inventors: • Davis, Eric Morgantown, WV 26508 (US) (54) Compositions comprising nebivolol (57) The active ingredients of the pharmaceutical composition described consist of nebivolol, one or more ACE inhibitors and one or more ARB. EP 2 808 015 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 808 015 A1 Description [0001] This application is a continuation-in-part of application Ser. -
List of Reactive Chemicals
LIST OF REACTIVE CHEMICALS Chemical Prefix Chemical Name Reactive Reactive Reactive CAS# Chemical Chemical Chemical Stimulus 1 Stimulus 2 Stimulus 3 111-90-0 "CARBITOL" SOLVENT D 111-15-9 "CELLOSOLVE" ACETATE D 110-80-5 "CELLOSOLVE" SOLVENT D 2- (2,4,6-TRINITROPHENYL)ETHYL ACETATE (1% IN ACETONE & BENZENE S 12427-38-2 AAMANGAN W 88-85-7 AATOX S 40487-42-1 AC 92553 S 105-57-7 ACETAL D 75-07-0 ACETALDEHYDE D 105-57-7 ACETALDEHYDE, DIETHYL ACETAL D 108-05-4 ACETIC ACID ETHENYL ESTER D 108-05-4 ACETIC ACID VINYL ESTER D 75-07-0 ACETIC ALDEHYDE D 101-25-7 ACETO DNPT T 126-84-1 ACETONE DIETHYL ACETAL D 108-05-4 ACETOXYETHYLENE D 108-05-4 1- ACETOXYETHYLENE D 37187-22-7 ACETYL ACETONE PEROXIDE, <=32% AS A PASTE T 37187-22-7 ACETYL ACETONE PEROXIDE, <=42% T 37187-22-7 ACETYL ACETONE PEROXIDE, >42% T S 644-31-5 ACETYL BENZOYL PEROXIDE (SOLID OR MORE THAN 45% IN SOLUTION) T S 644-31-5 ACETYL BENZOYL PEROXIDE, <=45% T 506-96-7 ACETYL BROMIDE W 75-36-5 ACETYL CHLORIDE W ACETYL CYCLOHEXANE SULFONYL PEROXIDE (>82% WITH <12% WATER) T S 3179-56-4 ACETYL CYCLOHEXANE SULFONYL PEROXIDE, <=32% T 3179-56-4 ACETYL CYCLOHEXANE SULFONYL PEROXIDE, <=82% T 674-82-8 ACETYL KETENE (POISON INHALATION HAZARD) D 110-22-5 ACETYL PEROXIDE, <=27% T 110-22-5 ACETYL PEROXIDE, SOLID, OR MORE THAN 27% IN SOLUTION T S 927-86-6 ACETYLCHOLINE PERCHLORATE O S 74-86-2 ACETYLENE D 74-86-2 ACETYLENE (LIQUID) D ACETYLENE SILVER NITRATE D 107-02-08 ACRALDEHYDE (POISON INHALATION HAZARD) D 79-10-7 ACROLEIC ACID D 107-02-08 ACROLEIN, INHIBITED (POISON INHALATION HAZARD) D 107-02-08 ACRYLALDEHYDE (POISON INHALATION HAZARD) D 79-10-7 ACRYLIC ACID D 141-32-2 ACRYLIC ACID BUTYL ESTER D 140-88-5 ACRYLIC ACID ETHYL ESTER D 96-33-3 ACRYLIC ACID METHYL ESTER D Stimulus - Stimuli is the thermal, physical or chemical input needed to induce a hazardous reaction.