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Emtree Release Notes May 2018

Emtree Release Notes May 2018

Emtree 2018.02 release notes

With the May 2018 Emtree release, 1019 preferred terms (155 drug terms and 864 non-drug terms) were added compared with the previous version released in January 2018. In total Emtree 2018.02 counts 81,003 preferred terms and over 355,000 synonyms.

Drugs and chemicals  Incorporation of the United States Adopted Names published from Nov. 2017–Feb. 2018.  Incorporation of newly approved drugs, drugs under consideration and drug trade names as published by the FDA and EMA from Nov. 2017–Feb. 2018.  Incorporation of 118 proposed international propriety names (INN) published by the WHO and incorporation of published corrections on previous lists.

Medical devices  Expansion and synonym enrichment of the ‘medical device’ branch.  Addition of 3,673 device trade names.  In total, 615 new medical device concepts were added. Areas of focus include: * ‘diagnostic kit’ branch: addition of 50 new concepts; * ‘prosthesis and orthosis’ branch: addition of 54 new concepts; * ‘catheters and tubes’ branch: addition of 32 new concepts; * ‘bandages and dressings’ branch: addition of 24 new concepts; * ‘dental device’ branch: addition of 47 new concepts; * ‘nerve stimulator’ branch: addition of 14 new concepts; * ‘ostomy device’ branch’: addition of 13 new concepts; * ‘forceps’ branch: addition of 10 new concepts; * ‘endoscope’ branch: addition of 20 new concepts; * ‘lens implant’ branch: addition of 10 new concepts.

 Review and restructuring of the ‘orthopedic prosthesis and orthosis’ and ‘orthopedic implant’ branches.

Disease terms Addition of 20 experimental disease terms (example: ‘experimental parasitosis’; ‘kindled seizure’; ‘lipopolysaccharide-induced septic shock’; ‘photothrombotic stroke’)

Procedures  Addition of ‘chimeric antigen receptor immunotherapy’ together with narrower terms ‘chimeric antigen receptor T-cell immunotherapy’ and ‘chimeric antigen receptor natural killer cell immunotherapy’.  Gathering of ‘/spectrometry’-branches into one hierarchy and addition of 66 new concepts and frequent synonyms and acronyms.  Revision of the ‘extracts and extraction’ branch and addition of 6 new concepts.

Organisms  Addition of 4 new dog breeds.  Hierarchical improvement of some organism branches (example: giant and red panda).  Addition and update NCBI of taxonomy IDs, merging and rearrangement of several organism names to follow the NCBI (6 concepts). 2

Emtree Terms Added and Changed (May 2018)

This is an overview of new terms added and changes made in the second Emtree release in 2018.

Overall, Emtree has grown by 1,019 preferred terms (155 drug terms and 864 non-drug terms) compared with the previous version released in January 2018. In total Emtree now counts 81,003 preferred terms.

Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept.

The terms added and changed are summarized below and specified in detail on the following pages.

Emtree Terms Added in May 2018

1,104 new terms (including 85 replacement terms and promoted synonyms) were added to Emtree as preferred terms in version May 2018 (compared to January 2018):

 189 drug terms (terms assigned to the Chemicals and Drugs facet).  915 non-drug terms (terms not assigned as Chemicals and Drugs).

The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2018 (typically as candidate terms), sometimes for several years, before they were added to Emtree.

Emtree Terms Changed in May 2018

85 terms (36 drug terms and 49 non-drug terms) from Emtree January 2018 have been replaced by 83 different terms in May 2018 (36 drug terms and 47 non-drug terms).

Of these, 56 terms (32 drug terms and 24 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2018; the remaining 27 replacement terms (4 drug terms and 23 non-drug terms) were already present in Emtree.

No drug terms were replaced by a non-drug term, no non-drug terms were replaced by a drug term. No preferred terms were deleted.

Changes are presented in alphabetical order of the new terms. Emtree Terms Added in May 2018 3

Drug terms

abeprazan dolutegravir plus emtricitabine plus tenofovir abivertinib alafenamide abrezekimab domatinostat acetylsalicylic acid plus atorvastatin plus drf 1042 ramipril edicotinib acetylsalicylic acid plus caffeine edit 101 acetylsalicylic acid plus caffeine plus efavaleukin alfa paracetamol efgivanermin alfa ach 0144471 efineptakin alfa ak 002 efinopegdutide aminohydrolase inhibitor eftansomatropin alfa amlodipine besylate plus lisinopril ehp101 apadamtase alfa elismetrep apraglutide enapotamab artificial enzyme enapotamab vedotin asalhydromorphone epaminurad atenolol plus indapamide epeleuton avasopasem manganese eprinomectin plus fipronil plus methoprene baloxavir plus praziquantel belantamab ertugliflozin plus sitagliptin belantamab mafodotin erythromycin plus zinc acetate belvarafenib estradiol plus estriol plus norethisterone benzhydrocodone plus paracetamol acetate benzoyl peroxide plus erythromycin estradiol plus trimegestone bersanlimab etidaligide bifikafusp alfa etigilimab bizalimogene ralaplasmid faricimab borofalan b 10 firsocostat bulevirtide fluoride free prophylaxis toothpaste cannabidivarin fluoride prophylaxis toothpaste cedazuridine fluorocyclopentenylcytosine cedazuridine plus decitabine fusion protein cellprotect (cell therapy agent) gadopiclenol cemiplimab ganaplacide cetrelimab gancotamab cevidoplenib glucopyranosyl lipid A chemoprotective agent glucosamine sulfate plus lidocaine chlorhexidine acetate plus tixocortol pivalate gsk 2857916 cibisatamab Haemophilus influenzae type b plus Neisseria ciforadenant meningitidis group C vaccine cilofexor hora pde6b cligosiban hora rpe65 clotrimazole plus fluconazole house dust mite allergen extract conteltinib ibrexafungerp cusatuzumab ibuprofen isobutanolammonium cxd 101 ibuprofen plus heparinoid s debio 1347 idn 7314 delolimogene mupadenorepvec imaprelimab deutivacaftor impression material diazoxide choline iscalimab diroleuton ivabradine plus metoprolol Emtree Terms Added in May 2018 4 kl 1333 revosimeline lanraplenib rgx 121 lenvervimab ripretinib leronlimab risdiplam licogliflozin rivoceranib lifileucel roblitinib linerixibat roluperidone linzagolix romilkimab lisocabtagene maraleucel saccharomyces boulardii concentrate livoletide sag 101 loratadine plus pseudoephedrine salvecin macozinone samrotamab Marek disease and Newcastle disease vaccine samrotamab vedotin mavilimogene ralaplasmid satoreotide tetraxetan mavorixafor satoreotide tetraxetan lu 177 mifepristone plus misoprostol seclidemstat mosedipimod selectin (glycoprotein) nedisertib setafrastat nemorexant sodium glucose cotransporter 1 inhibitor netakimab spinetoram nevanimibe sulfatinib nidufexor sutimlimab nirsevumab tagraxofusp octenidine plus phenoxyethanol talditercept alfa ombipepimut S tanziertib omburtamab tavokinogene telseplasmid onfekafusp alfa tavolimab onvatilimab tebentafusp ory 1001 tegavivint otaplimastat telratolimod otilimab tengonermin parimifasor tepoditamab pegcetacoplan timbetasin pemigatinib tofersen phosphotransferase activator tomivosertib pn 1007 tricaprilin pooled plasma (human) troloxamide quinone porfimer tumor necrosis factor activator praconase upacicalcet prn1008 valanafusp alfa prophylaxis toothpaste valemetostat prx asl vanalimab qr 313 vasculotropin activator ravagalimab viltolarsen rebisufligene etisparvovec vopratelimab reldesemtiv zilucoplan reproxalap Emtree Terms Added in May 2018 5

Non-drug terms

8-azaguanine-resistant cell line beta spectrometry A2780/R cell line bicuculline-induced seizure abdominal orthosis bile reflux monitor accomodative intraocular lens biliary balloon dilatation catheter acetic acid-induced gastric ulcer bilirubin test kit actigraph binocular vision test kit active support bandage bioinformatics software acupressure device biopsy punch acupuncture device biopsy valve acustimulation device bipolar forceps Ailuridae birthing pool Ailuropoda bite wafer Ailurus blood transfusion device airway balloon dilation catheter blunt obturator allergy skin test device body splint alpha spectrometry bone curette Americamysis bone elevator Americamysis bahia bone marrow biopsy needle Ampullariidae border collie amygdala-kindled seizure brachytherapy catheter anal fistula closure device bracket gauge analgesic infusion pump brain-responsive neurostimulator breast cancer prognostic test kit angle resolved photoemission spectroscopy breast examination kit anterior cervical plate breathing circuit tube antibacterial dressing BRL cell line (liver) antimicrobial dressing broadband dielectric spectroscopy arm splint broxuridine-resistant cell line arm tourniquet cadexomer iodine dressing array scanner calf implant arterial cannula calibrated spoon arthroscopic equipment calprotectin test kit arthroscopic probe cancer detection kit artificial bladder cancer prognostic test kit artificial chorda tendinae cancer stem cell line aspheric contact lens capillary electrophoresis- aspheric intraocular lens carbon dioxide cylinder aspheric toric intraocular lens catheter navigation system Asterias amurensis Cavalier King Charles spaniel Asterias rubens cavity ring down spectroscopy atmospheric pressure chemical ionization mass celiac disease test kit spectrometry cell separation device atomic spectrometry cellular processing device audiovisual recording central venous catheter navigation system auditory brainstem response screening device centric relation balance training system cervical spine immobilization device balloon colonoscope cervical thoracic orthosis balloon enteroscope chemical ionization mass spectrometry bandage retainer chimeric antigen receptor immunotherapy BC cell line (breast cancer) chimeric antigen receptor natural killer cell Bedlington terrier chimeric antigen receptor natural killer cell benzo[a]pyrene resistant cell line immunotherapy Emtree Terms Added in May 2018 6 chimeric antigen receptor T-cell dental grinding and milling machine chimeric antigen receptor T-cell immunotherapy dental implant guide Chinese medicine equipment dental milling machine chiropody dressing dental parameters chiroptical spectroscopy dental polishing circularly polarized luminescence dental prosthesis and implant equipment closed system transfer device dental prosthesis manufacturing machine closed wound drain dental screw driver Clostridium difficile test kit dental spacer coagulation surgery dental syringe cocker spaniel dental tongue retractor coherent anti Stokes dental torque wrench colchicine-resistant cell line dental wedge cold compress denture base material colon content denture gauge colonic lamina propria denture lining material colonoscopic accessory denture material colorectal cancer detection kit Desulfurococcus mucosus colorectal cancer prognostic test kit dexamethasone-resistant cell line colostomy dressing diagnostic compress dielectric relaxation spectroscopy computed tomography simulator diffuse computerized rhinomanometer spectroscopy Coniochaeta diffusing wave spectroscopy Coniochaetales digestive endomicroscope consciousness monitor discrete wavelet transform contact lens tonometer dissecting forceps contact profilometry DNA purification kit continuous glucose monitoring system dorsal dentate gyrus continuous wavelet transform dorsolateral periaqueductal gray contrast medium injector dose limiting syringe contrast sensitivity chart double balloon enteroscope conventional simulator double lumen hemodialysis catheter corneal collagen cross-linking device dressing forceps corneal epithelial removal device drug measuring device corrosion casting drug of abuse test kit CPR equipment drug test kit crash test dummy dual polarization interferometry cryoablation device dysphagia aid cryotherapy device ear splint Cryptosporidium test kit elastic exerciser cystic fibrosis test kit elbow crutch cytocentrifuge electroencephalography monitoring dabrafenib-resistant cell line electromagnetic tracking device dacryendoscope electron impact mass spectrometry dactinomycin-resistant cell line electronic autoinjector data compression electronic balance daunorubicin-resistant cell line electronic deep brain stimulation electrode electropalatography speech training system deep brain stimulator electroporation system dental 3D printer electroretinograph dental cheek retractor electrosurgery forceps dental diagnostic handpiece encapsulated cell biodelivery device dental dressing Encyrtidae Emtree Terms Added in May 2018 7 endocervical curette fetal head elevator endoscope positioning system fiber optic handpiece endoscope sheath fiberoptic laryngoscope endoscope washer-disinfector field asymmetric waveform ion mobility endoscopic bite block spectrometry endoscopic light source field desorption mass spectrometry endoscopic retrograde filter needle cholangiopancreatography cannula finger extension exerciser endoscopic ultrasound processor fire extinguisher endovenous sealing device fixed orthodontic appliance component energy dispersive X ray fluorescence flame atomic absorption spectrometry spectroscopy flameless atomic absorption spectrometry engineered amniotic membrane graft flash photolysis engineered cell flexible laparoscopic scissors enzyme assisted extraction flexor tendon prosthesis epidural access device flow diverter erection assistance device fluorescence in situ hybridization kit erlotinib-resistant cell line fluorophotometer esophageal atresia repair device Fourier transform esophageal balloon dilatation catheter fourier transform ion cyclotron resonance mass esophageal brachytherapy catheter spectrometry esophageal cell sampling device Fourier transform spectroscopy esophagus catheter freezer etoposide-resistant cell line functional knee brace ex vivo lung perfusion device gait analysis system exercise and fitness equipment gait trainer exhaled breath condensate collection device gallbladder wall experimental active cutaneous anaphylaxis gamma probe experimental alcoholism gastric balloon extractor experimental aspergillosis gastrointestinal content experimental cerebral hemorrhage gastrostomy button experimental drug addiction gastrostomy device experimental helminthiasis gel compress experimental liver ischemia-reperfusion injury genetic disease test kit experimental mycosis genu (corpus callosum) experimental nociception Giardia test kit experimental parasitosis GIST-T1 cell line experimental schistosomiasis Gladiolus experimental subarachnoid hemorrhage gluteus implant experimental venous thrombosis graft preparation device experimental viral infection graft sizing block expiratory limb respiratory tube gynecological scissors exsanguinator halitosis measurement device extended X ray absorption fine structure HBEC cell line (bronchial epithelium) spectroscopy HCE cell line (colon epithelium) external aorta root prosthesis HCE cell line (cornea epithelium) extraction balloon catheter HCEC cell line (cornea endothelium) eye pressure shield headspace extraction eye tracking system headspace solid phase microextraction eyelid closure weight healthcare software feature extraction heart right ventricle wall femoral component of hip prosthesis Helicobacter pylori test kit femoral head cartilage hematocrit test kit fertility monitor hematrocrit centrifuge Emtree Terms Added in May 2018 8 hemoglobin test kit inspiratory limb respiratory tube hemostatic catheter insulin delivery device hemostatic nose clip insulin inhaler hemostatic sponge intercanine width hepatitis B virus test kit interferon beta autoinjector hepatitis C virus test kit interincisal angle hepatitis test kit intermaxillary fixation device HER2 fluorescence in situ hybridization kit intermolar width HER2 protein detection kit internal normalized ratio test strip herpes simplex virus 1 test kit interventional nuclear magnetic resonance herpes simplex virus 2 test kit scanner herpes simplex virus test kit intestine content high resolution scanning electron intra-abdominal white adipose tissue high resolution transmission electron intracompartmental pressure monitor microscopy intracorneal lens implant high throughput sequencer intracoronal attachment hip-knee-ankle-foot orthosis intramedullary reamer HK-2 [Human kidney] cell line intraocular capsular anchor HMEC cell line (microvascular endothelial) intraoperative optical coherence tomography HRMEC cell line (kidney) device HRMEC cell line (retina) intraoral camera human papillomavirus test kit intraoral suture hybrid contact lens intraosseous needle hydrogen breath analyzer intrauterine device retriever hydrogenosome intravaginal urethral occlusion device hydrophobic intraocular lens intravasal thread hypoallergenic adhesive tape iodine dressing hysterosalpingogram catheter ion mobility spectrometry-mass spectrometry hysterosalpingography dye injection set Irpex lacteus ice pack irregular surface compensator image retrieval device Jewett brace immunoapheresis device keratoscopic astigmatic ruler immunochemistry analyzer kindled seizure immunochromatographic kit knee immobilizer immunohistochemical test kit knee orthosis impedance spectroscopy knee sleeve impedance-pH monitor knee-ankle-foot orthosis implant depth dental gauge krypton chloride laser implantable drug delivery system L form (cell) implantable insulin pump laparoscopic access suction dome implantable peroneal nerve stimulator laparoscopic biopsy forceps implantable subthalamic nucleus stimulator laparoscopic carbon dioxide insufflator implanted spinal ganglion stimulator laparoscopic grasping forceps inductively coupled plasma atomic emission laparoscopic simulator spectrometry laparotomy sponge inductively coupled plasma mass spectrometry laptop inflatable penile ring laryngeal implant influenza virus test kit laryngeal keel infrapatellar fat pad laryngeal infrared skin laryngeal speculum infusion rate monitor laser ablation inductively coupled plasma mass inhalation capsule spectrometry injectable knee implant laser ablation system insemination device laser cutting device Emtree Terms Added in May 2018 9 laser desorption ionization mass spectrometry methylation-specific PCR assay kit laser Doppler flowmeter micro-CT scanner laser endoscope microbial identification system laser induced breakdown spectroscopy microPET scanner laser induced fluorescence spectroscopy camera laser lithotripter ablation device laser spectroscopy microwave assisted extraction laser-resistant endotracheal tube microwave generator lateral septal nucleus military antishock trousers latex glove mobile health application leg orthosis moisture barrier dressing leg splint moisture chamber spectacles leg tourniquet moldable splint Legionella pneumophila test kit monopolar forceps Leiurus quinquestriatus morphine-induced antinociception Lemna paucicostata motor symptoms monitoring device leukocytapheresis device mouth ulcer patch lice comb MRI-guided laser ablation device ligature director multifocal electroretinograph light-adjustable intraocular lens implant multifocal toric contact lens lingual brace multifocal toric intraocular lens lipopolysaccharide-induced septic shock Murine hepatitis virus (strain A59) litmus paper Murine norovirus local anesthetic device Murine norovirus 1 Locusta migratoria migratorioides muscle activity monitor long leg cast nasal air filter Loricariidae nasal dressing lossless compression nasal tissue lossy compression nasogastric feeding apparatus lower esophageal sphincter stimulation near infrared spectrophotometry lower esophageal sphincter stimulation system needle guide Luer lock syringe negative staining lumbo sacral orthosis Neochloris lumbosacral corset neodymium YVO4 laser lung brachytherapy catheter nerve conduction testing device Lycopersicon nerve conduit MAC-T cell line neurosensory testing device Machupo virus neurosurgical pad magnetic bead separation device newborn auditory screening device mandible implant nipple shield Martyniaceae nitric oxide breathanalyzer maternal aunt non-invasive prenatal test kit maternal uncle nonabsorbable mesh maxillary prosthesis noninvasive glaucoma drainage device mechanical lithotripter noninvasive spinal traction device mechanical stethoscope nontunneled central venous catheter medical laser nose speculum medication adherence monitoring system NPE cell line (nasopharyngeal epithelium) medicine cup NPE cell line (non-pigmented epithelium) medicine dropper nuclear track detector meibography Oerskovia meibography device ophthalmic drug insert meningitis test kit ophthalmic YAG laser mesenteric arterial bed ophthalmological monitor Emtree Terms Added in May 2018 10 ophthalmological surgical microscope patient slider optical coherence tomography - scanning laser patient vital sign monitor ophthalmoscope pavlik harness optical pachymeter Pavlova optical profilometry PCR assay kit optical spectroscopy Pectinophora oral syringe pectoralis implant organ transplantation equipment pelvic belt orthodontic aligner pelvic floor muscle exercise trainer orthodontic coil spring penile ring orthodontic elastic penrose drain orthodontic ligature Pentatrichomonas orthopedic hammer Pentatrichomonas hominis orthopedic implant delivery device percutaneous endoscopic gastrostomy tube orthopedic retractor perianal support toilet seat orthopedic screwdriver pericardial drainage catheter orthopedic traction wrap Perkins applanation tonometer orthopedic trocar Pestalotiopsis Osmerus pH test strip Osmerus mordax Phaeobacter osmotically controlled oral drug delivery system Phaeobacter inhibens osseointegrated implant Phalaenopsis osteotomy guide Phallusia ostomy bag protector pharmacokinetic modeling software ostomy barrier ring Phormidium ostomy dressing photic simulator ostomy support device photoelectron spectroscopy otoacoustic emission screening device photographic paper otorhinolaryngology speculum photopheresis system ouabain-resistant cell line photoscreener ovulation test kit phototherapy lamp oxygen blender photothrombotic stroke oxygen concentrator phrenic nerve stimulator oxygen monitor physical assistive training device pacemaker battery Phytoseiulus Pachysolen Phytoseiulus persimilis Pachysolen tannophilus Pimelodidae Palaemon pugio pink bollworm palpebral spring Pisaster papillotome Pisaster ochraceus paraffin embedding Pithomyces paraffin gauze dressing Planorbella Paramecium bursaria Chlorella virus 1 Planorbella trivolvis paramedic response kit Planorbis parastomal hernia support belt plant gamete paraveterinary worker plasma desorption mass spectrometry Pardosa plaster jacket parenteral nutrition bag plaster of Paris bandage partial lower denture embedding partial upper denture Plumeria patency capsule Plumeria rubra paternal aunt pneumatic balloon paternal uncle pneumatic dental drill patient simulator pneumatonometer Emtree Terms Added in May 2018 11 podoscope rapid urease test kit Pogonomyrmex reflectometric interference spectroscopy polymer tooth crown rehabilitation robot polypectomy snare removable retainer Pomacea removable space maintainer Pomacea canaliculata replogle tube poodle respiratory exerciser porcelain jacket crown respiratory gas monitor porcine xenograft bioprosthesis respiratory monitor Porites respiratory syncytial virus test kit Porites astreoides restorative material cannula porous polyethylene orbital implant retraction notice posterior cervical plate retrograde guidewire postpyloric feeding tube rhinospirometer posture correction brace rhodamine 6G dye laser potential acuity meter Rhodotorula toruloides povidone iodine dressing rib fracture orthosis Pratylenchus rigid cystoscope preclinical fluorescence imaging system rigid intramedullary nail preclinical MRI scanner ring pessary preclinical PET-MRI scanner RMC cell line (retina) precordial stethoscope RMC-1 cell line (breast adenocarcinoma) pressure support ventilator rMC-1 cell line (retina) Proboscidea (plant) RNA purification kit Prochilodontidae robotic surgery simulator Prochilodus root canal obturator Prochilodus lineatus rotavirus test kit profilometry ruby laser prophylactic knee brace Rutherford backscattering spectrometry prosthetic vascular graft sacral nerve stimulator protein analyzer sacroiliac orthosis protein array kit system proton transfer reaction mass spectrometry sample purification kit Protophormia scalp tourniquet Protophormia terraenovae scanning laser polarimeter prussian blue staining scanning tunneling spectroscopy pseudoisochromatic plate scar dressing pump probe spectroscopy Schiotz tonometer pyrolysis mass spectrometry schnauzer radial artery catheter scintillation counter radial artery tourniquet scleral fixated intraocular lens radiation protective drape sclerectomy implant radioallergosorbent test kit sclerotherapy needle radiofrequency coil self-contained breathing apparatus radiofrequency generator shadowing (histology) radiology breast postitioning device sharps container radiology limb positioning device shelf pessary radiology neck positioning device Shetland sheepdog radiology pelvis positioning device shielding block radiology positioning device short bevel needle radiology whole body positioning device shoulder brace radionuclide generator shoulder spica rapid infusion catheter single balloon enteroscope rapid infusion system single energy X ray absorptiometry Emtree Terms Added in May 2018 12 single lumen catheter surgical driver single vision spectacles surgical margin assessment device sinus balloon catheter surgical planning system sinus probe surgical probe sizing balloon catheter surgical rasp skin expander surgical simulator skin graft donor site dressing suture button skin graft mesher swallow (bird) skin grafting instrument sweat analyzer skin parasite removal device sweat collection system skin retractor syringe pump skin stapler tablet computer skin traction device tear test strip skinfold calliper telescope lens implant small intestine content telescopic crown-retained removable partial smoke evacuation device denture soft cast temporomandibular joint prosthesis soil extract temporomandibular joint splint specimen container tendon forceps speech synthesizer tendon tunneler speech training software terahertz time domain spectroscopy spica cast testicular implant spinal frame text to speech technology device spinal ganglion stimulator therapeutic drug test kit spinal rod fixation system thermocouple spine corrector thoracic orthosis spine orthosis thoracolumbosacral orthosis spine spondylolisthesis fixation orthosis thumb spica cast splenium tick tweezers sponge forceps tilting disc prosthesis sponge holder time resolved fluorescence spectroscopy springer spaniel time resolved infrared spectroscopy stadiometer time resolved mass spectrometry stainless steel crown time resolved near infrared spectroscopy stainless steel suture time resolved photoelectron spectroscopy standing frame time resolved spectroscopy stapes prosthesis tioguanine-resistant cell line staple remover tissue cassette stimulation electromyograph tissue embedding straight-pull headgear titanium mesh subcutaneous port needle titanium sapphire laser suction canister tongue depressor sudomotor function measurement device tonometer prism sugar tong splint tooth extraction forceps sum frequency generation spectroscopy tooth shape sump drain toric contact lens sun protective clothing toric intraocular lens supplied-air respirator tourniquet machine support bandage tracheoscope surface assisted laser desorption ionization tracheostomy button mass spectrometry tracheostomy collar surface enhanced laser desorption ionization tracheostomy device mass spectrometry tracheostomy dressing surface enhanced Raman spectroscopy tracheostomy holder Emtree Terms Added in May 2018 13 tracheostomy spacer dispersive X ray spectroscopy transcranial alternating current stimulation wavelet transformation transcranial alternating current stimulator wearable computer transcranial direct current stimulator West Highland white terrier transcranial electrical stimulator white cane transcranial random noise stimulation widefield microscope transcranial random noise stimulator wind farm transcutaneous vagus nerve stimulator wound closure strip transient X ray absorptiometry transmucosal drug delivery system X ray absorption near edge structure transpalatal arch spectroscopy transpalpebral tonometer X ray emission spectroscopy transscleral iontophoresis device X ray fluorescence spectrometry treatment planning software x ray image enhancer Treponema pallidum test kit X ray photoemission spectroscopy triclosan eluting ureter stent x ray processing unit triple quadrupole mass spectrometry x ray protective clothing tubular retractor X ray spectroscopy tumor treating field generator xenograft dressing tunable diode laser absorption spectroscopy YAMC cell line tunneler ultrasonic cavitation device ultrasonic pachymeter ultrasonic scalpel ultrasound assisted extraction ultrasound biomicroscope ultrasound speech training system photoelectron spectroscopy ultraviolet visible spectrophotometry ultraviolet visible spectroscopy unit dose drug distribution system upper ileum urine specimen collector vacuum erection assistance device vascular introducer vastus intermedius muscle vastus muscle ventral dentate gyrus ventral pons ventricular drain ventrolateral periaqueductal gray vibrational circular dichroism vibrational spectroscopy Vibrio cholerae test kit video game console video processor videootoscope virtual reality simulator visible spectrophotometry warm compress water jet dissector waterproof cast wavelength dispersive X ray fluorescence spectroscopy 14

Drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term acetylsalicylic acid plus caffeine plus paracetamol excedrin apadamtase alfa shp655 benzoyl peroxide plus erythromycin benzamycin bevacizumab* bevacizumab beta borofalan b 10 4 boronophenylalanine b 10 caffeine plus paracetamol plus propyphenazone* saridon cligosiban pf 3274167 diroleuton dihomo gamma linolenic acid erythromycin plus zinc acetate zineryt estradiol plus norethisterone acetate* trisequens faricimab ro 6867461 fusion protein hybrid protein house dust mite allergen extract house dist mite allergen extract leronlimab PRO 140 loratadine plus pseudoephedrine claritin D mavorixafor 8 [(4 aminobutyl)(2 benzimidazolylmethyl)amino] 1,2,3,4 tetrahydroquinoline nalotimagene carmaleucel* zalmoxis (drug) nevanimibe 1 (2,6 diisopropyl) 3 [[1 [4 (dimethylamino)phenyl]cyclopentyl]methyl]urea omburtamab burtomab ory 1001 1 amino 4 (2 phenylcyclopropylamino)cyclohexane otilimab gsk 3196165 pegcetacoplan apl 2 pooled plasma (human) octaplas porfimer photofrin rivoceranib apatinib romilkimab sar 156597 saccharomyces boulardii concentrate perenterol satoreotide tetraxetan ops201 selectin (glycoprotein) selectin tagraxofusp diphtheria toxin interleukin 3 tanziertib 2 [1 [(6 amino 5 cyano 4 pyrimidinyl)amino]ethyl] 3,4 dihydro 4 oxo 3 phenylpyrrolo[2,1 f][1,2,4]triazine 5 carbonitrile tavolimab tavolixizumab timbetasin thymosin beta4 tofersen isis sod1rx tricaprilin trioctanoin zilucoplan ra 101495

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Non-drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term

A-549 cell line* A-459 cell line Americamysis bahia Mysidopsis bahia BC cell line (breast cancer) BC cell line BGC-823 cell line* BCG cell line CEM/C1 cell line* C1 cell line Debaryomyces hansenii* Candida famata Desulfurococcus mucosus Desulfurococcus mobilis DNA microarray* gene array elbow prosthesis* elbow implant experimental liver ischemia-reperfusion injury ischemia-reperfusion-induced liver injury femur prosthesis* femur implant GIST-T1 cell line GIST-T-1 cell line HBEC cell line (bronchial epithelium) HBEC cell line (bronchial) HCE cell line (colon epithelium) HCE cell line (colon) HCE cell line (cornea epithelium) HCE cell line (cornea) HCEC cell line (cornea endothelium) HCEC cell line (cornea) HMEC cell line (microvascular endothelial) HMVEC cell line HRMEC cell line (kidney) HRMEC cell line (renal) HRMEC cell line (retina) HRMEC cell line (retinal) impedance spectroscopy electrochemical impedance spectroscopy infrared spectroscopy* infrared spectrometry joint prosthesis* joint endoprosthesis knee prosthesis* knee endoprosthesis NPE cell line (nasopharyngeal epithelium) NPE cell line (nasopharyngeal) NPE cell line (non-pigmented epithelium) NPE cell line (non-pigmented) orthokeratology lens* overnight contact lens Palaemon* Palaemonetes Palaemon pugio Palaemonetes pugio patella prosthesis* patellar implant Penicillium* Eupenicillium photoacoustic spectroscopy* photoacoustic spectrometry photoelectron spectroscopy X ray photoelectron spectroscopy retraction notice retracted article Rhodotorula* Rhodosporidium Rhodotorula toruloides Rhodosporidium toruloides RMC cell line (retina) RMC cell line (retinal) RMC-1 cell line (breast adenocarcinoma) RMC-1 cell line rMC-1 cell line (retina) rMC-1 [retinal] cell line spectrofluorometry* fluorescence spectroscopy spectroscopy* spectrometry swallow (bird) swallow tendon prosthesis* tendon implant Theileria equi* Babesia equi thumb joint prosthesis* thumb joint implant ulna head prosthesis* ulna head implant wrist prosthesis* wrist implant X ray spectroscopy X ray spectrometry X ray spectroscopy roentgen spectroscopy

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