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UCL Institute of Neurology Queen Square the Institute Of UCL Institute of Neurology Queen Square The Institute of Neurology is a specialist postgraduate institute of UCL. It is closely associated in its work with the National Hospital for Neurology & Neurosurgery, University College London Hospitals' NHS Foundation Trust, and in combination they form a national and international centre at Queen Square for teaching, training and research in neurology and allied clinical and basic neurosciences. The Institute of Neurology is a key component of the newly formed Faculty of Brain Sciences at UCL, and has eight academic Departments. These encompass clinical and basic research within each theme: Brain Repair and Rehabilitation (Professor Xavier Golay); Clinical and Experimental Epilepsy (Professor Matthew Walker), Clinical Neurosciences, Royal Free campus, (Professor Tony Schapira), Imaging Neuroscience (Professor Ray Dolan); Molecular Neuroscience, incorporating the Reta Lila Weston Institute of Neurological Studies (Professor John Hardy); Motor Neuroscience and Movement Disorders (Professor Linda Greensmith); Neurodegenerative Disease (Professor John Collinge); Neuroinflammation (Professor Ken Smith). In parallel, there are currently six Divisions representing professional affiliations: Clinical Neurology; Neurosurgery; Neurophysiology; Neuropathology; Neuropsychiatry and Neuropsychology; and Neuroradiology and Neurophysics. The Institute employs over 500 staff, occupies some 12,000 sq m of laboratory, lecture room and office space, and has a current annual turnover of £53m. The Institute receives over £33m per annum in grants for research from the principal medical charities concerned with neurological diseases, and from government agencies such as the Medical Research Council. Approximately 18% of the Institute's funding is obtained from the Higher Education Funding Council for England which has awarded high ratings for the Institute in each of the national Research Assessment Exercises since 1986. The Institute currently holds over 300 active grants, supporting research into the causes and treatment of a wide range of neurological diseases, including movement disorders, multiple sclerosis, epilepsy, brain cancer, stroke and brain injury, muscle and nerve disorders, cognitive dysfunction and dementia, and the work of the Institute's clinical academic staff is closely integrated with the Hospital's care of patients. Generous support for research is provided through grant awards from the medical research charities: in particular, the Brain Research Trust http://www.brt.org.uk Continuing the record of exceptional achievement in previous Research Assessments (RAE), the Institute performed very strongly in the 2008 RAE. Almost 100 FTE staff were submitted for evaluation, including a number of outstanding early career researchers. Overall 70% of our research was deemed to be internationally competitive or world leading, and submitted papers were very highly cited, with an average citation rate over the assessment period of 40 times per paper. Three areas of research in particular were identified as world-leading: Cognitive neuroscience & human brain imaging, Inherited diseases & molecular, cellular and genetic neuroscience, and Neurodegenerative disease. UCL Neuroscience is currently rated second in the world by ISI Essential Science Indicators, and four of the top twelve most highly cited authors working worldwide in neuroscience and behaviour are based at the IoN. In the calendar year 2010, Institute staff published 968 papers, 22 book chapters and 7 books. Forty papers were published in the top 50 of all scientific journals, including Science, Nature, Cell and New England Journal of Medicine. There are seven Fellows of the Royal Society at Queen Square. A number of important research centres are based at the Institute of Neurology. These include: Wellcome Trust Centre for Neuroimaging http://www.fil.ion.ucl.ac.uk/ MRC Prion Unit http://www.prion.ucl.ac.uk/ MRC Centre for Neuromuscular Disease http://www.cnmd.ac.uk/ Dementia Research Centre http://www.dementia.ion.ucl.ac.uk/ Department of Health Dementias and Neurodegenerative Diseases Research Network (DENDRON) http://www.dendron.org.uk/ The Institute also has active collaborative research programmes with the Institute of Cognitive Neuroscience and the Gatsby Computational Neuroscience Unit, co-located at Queen Square and which will play an important role in the new Sainsbury Wellcome Centre for Neural Circuits and Behaviour. The UCL Institute of Neurology has a significant postgraduate teaching and training portfolio, with over 200 graduate students at Queen Square, and taught MSc courses in: Advanced Neuroimaging; Brain and Mind Sciences (an innovative two year, two centre programme); Clinical Neuroscience; and Clinical Neurology. A new distance-learning Diploma in Clinical Neurology (E-Brain) was launched in Autumn 2011. Excellent graduate students of the highest quality are recruited to both ION and UCL-wide PhD programmes, including the ION hosted MRC DTA funded 4-year PhD in Clinical Neurosciences, and the Wellcome 4-year PhD in Neuroscience, which are supported through Research Council, charity and industry funded studentships. Institute staff contribute to undergraduate teaching of clinical neurology for the UCL Medical School. Full details of the Institute’s research and teaching activity can be found on the Institute of Neurology website at http://www.ucl.ac.uk/ion UCL INSTITUTE OF NEUROLOGY Wellcome Trust Centre for Neuroimaging Research Associate or Senior Research Associate MR Data Analysis Scientist Post: ResearchAssociateorSeniorResearchAssociate Department: MRIPhysicsGroup,WellcomeTrustCentreforNeuroimaging Grade: UCLGrade7or8 Responsibleto: DrNikolausWeiskopf,SeniorLecturerandHeadof Physics Head of Department: Professor Ray Dolan, Kinross Professor of Neuropsychiatry Background: The Wellcome Trust Centre for Neuroimaging at UCL (WTCN; incorporating the Leopold Muller Functional Imaging Laboratory and the Wellcome Department of Imaging Neuroscience at the Institute of Neurology) is an interdisciplinary centre for neuroimaging excellence. We bring together clinicians and scientists who study higher cognitive function using neuroimaging techniques. Our goal is to understand how thought and perception arise from brain activity, and how such processes break down in neurological and psychiatric disease. The Centre studies all aspects of higher cognitive function and develops cutting edge data acquisition and analysis methods. Home to Statistical Parametric Mapping (SPM), the world's most popular tool for analysing neuroimaging data, the Centre seeks to answer fundamental questions about how the brain works, in order to improve human and animal health. We host and train over 100 clinicians, scientists and support staff, and interact with over 200 collaborators both at UCL and throughout the world. The Centre is equipped with three 3 T whole body scanners (Siemens Tim Trio inc. 32-ch head coil), an MEG system (CTF/VSM), and MR compatible EEG and TMS systems. One of the MRI systems will soon be equipped with an optical tracking system for prospective motion correction (Kineticor). The Wellcome Trust Centre for Neuroimaging is part of the Institute of Neurology and has close working relationships with the Institute of Cognitive Neuroscience (Director: Professor Geraint Rees) and the Gatsby Neurocomputational Unit (Director: Professor Peter Dayan). We also enjoy close links with colleagues in Psychology at UCL, the Economics Department at UCL (ELSE) and the National Hospital for Neurology and Neurosurgery (e.g., Prof. Xavier Golay). The post holder will be member of the WTCN Physics Group, which supports the ongoing neuroscience program by developing cutting-edge MR imaging techniques, pulse sequences and novel data processing methods and MR compatible hardware components. For further information on the group and its research goals, please see – http://www.fil.ion.ucl.ac.uk/Research/physics.html Main Purpose of the Post: As a member of the WTCN Physics Group, the post holder will be expected to support on-going neuroscience research. He/she will also pursue individual research projects aimed at the development of MR image reconstruction and data processing methods related to the primary projects of the WTCN Physics Group. This will be done with a close link to data acquisition including novel pulse sequences and cutting-edge optical prospective motion correction. These novel MRI methods will enable unprecedented studies of functional and anatomical microstructure – with the long-term goal of establishing in-vivo histology. High-resolution fMRI (~1mm) and anatomical MRI (~500μm); Ultra-fast fMRI enabling whole-brain imaging in less than 1s; Reduction of susceptibility artifact and physiological noise in fMRI; Real-time fMRI and neurofeedback of the BOLD response; Fast prospective motion correction based on optical tracking including real-time feedback to the MRI scanner; Parallel imaging and advanced image reconstruction including compressed sensing; Quality assurance and performance testing of MRI scanners to ensure data quality for top science; Computational neuroanatomical methods for measurement and multivariate assessment of cortical properties such as thickness, curvature, and laminar MR tissue properties; Developing models of cortical and subcortical microstructure and its effects on the MRI signal. Duties and Responsibilities: To develop and program Matlab, C++ and SPM based tools for image processing,
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