nutrients Article Anti-Inflammatory Potential of Cow, Donkey and Goat Milk Extracellular Vesicles as Revealed by Metabolomic Profile Samanta Mecocci 1,2 , Federica Gevi 3 , Daniele Pietrucci 4 , Luca Cavinato 5, Francesco R. Luly 5, Luisa Pascucci 1, Stefano Petrini 6 , Fiorentina Ascenzioni 5, Lello Zolla 3, Giovanni Chillemi 4,7,* and Katia Cappelli 1,2,* 1 Dipartimento di Medicina Veterinaria, University of Perugia, 06123 Perugia, Italy;
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[email protected] (L.P.) 2 Centro di Ricerca sul Cavallo Sportivo, University of Perugia, 06123 Perugia, Italy 3 Dipartimento di Scienze Ecologiche e Biologiche, Università della Tuscia, 01100 Viterbo, Italy;
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[email protected] (L.Z.) 4 Dipartimento per l’Innovazione Nei Sistemi Biologici, Agroalimentari e Forestali, Università della Tuscia, 01100 Viterbo, Italy;
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[email protected] (F.A.) 6 Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche, 06126 Perugia, Italy;
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[email protected] (K.C.); Tel.: +39-0761-357429 (G.C.); +39-075-5857722 (K.C.) Received: 12 August 2020; Accepted: 17 September 2020; Published: 23 September 2020 Abstract: In recent years, extracellular vesicles (EVs), cell-derived micro and nano-sized structures enclosed in a double-layer membrane, have been in the spotlight for their high potential in diagnostic and therapeutic applications.