Medical Robotics and Computer- Integrated Therapy Delivery: Coupling Information to Action in 21’St Century Surgery

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Medical Robotics and Computer- Integrated Therapy Delivery: Coupling Information to Action in 21’St Century Surgery Medical Robotics and Computer- Integrated Therapy Delivery: Coupling Information to Action in 21’st Century Surgery Russell H. Taylor Dept. of Computer Science/Radiology/Mechanical Engineering Director, Center for Computer-Integrated Surgical Systems and Technology The Johns Hopkins University 3400 N. Charles Street; Baltimore, Md. 21218 [email protected] NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Thanks to many people … • J. Anderson • J. Lazarus • K. Chinzei • W. Bargar • D. Long • N. Hata • A. Bzostek • K. Masamune • R. Kikinis • B. Eldridge • K. Murphy • D. Stoianovici • G. Fichtinger • D. Yousem • A. Patriciu • J. Funda • B. Jaramaz • L. Whitcomb • F. Frassica • A. DiGioia • R. Goldberg • A. Lahmer • A. Okamura • S. Gomory • M. Borner • C. Davatzikos • G. Hager • A. Bauer • E. Atalar • L. Joskowicz • A. Barnes • E. Zerhouni • Y. Kim • P. Jensen • L. Kavoussi • R. Kumar • J. Yao • P. Kazanzides • D. Shen • B. Mittelstadt • H. Paul • C. Riviere • M. Li • J. Wenz • D. Yousem • D. Sheng • E. DeJuan • A. Kalvin • D. Rothbaum • J. Roy • C. Cutting • A. Gueziec • A. Morris • M. Talamini … and many more NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 1 Prediction The impact of computer- integrated surgical systems and technology on medical care in the next 20 years will be as great as the impact of computer-integrated manufacturing systems and technology on industrial production over the past 20 years. Engineering Research Center for Computer Integrated Surgical Systems and Technology NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Basic means for fulfilling prediction: systems that integrate information to action • Provide new capabilities that transcend human limitations in surgery • Increase consistency and quality of surgical treatments • Promote better outcomes and more cost-effective processes in surgical practice NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 2 Patient Computers images & treatment and networks plans Decision Images & other Command & support & Treatment sensor data control commands records & outcome data Interface devices patient surgeon NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Preoperative Intraoperative Computer- Update Model Update Plan assisted planning Patient-specific Computer- Model Assisted Execution Postoperative Atlas Computer- Assisted Assessment Patient NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 3 Preoperative Intraoperative Computer- Update Model Update Plan assisted Surgicalplanning Surgical “CAD” “CAM” Patient-specific Computer- Model Assisted Execution Atlas Computer- Assisted SurgicalAssessment “TQM” Patient Postoperative NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Preoperative Intraoperative Computer- Update Model Update Plan assisted planning Surgical Patient-specific Computer- Model Assisted AssistantsExecution Postoperative Atlas Computer- Assisted Assessment Patient NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 4 NSF Engineering Research Center for Computer-Integrated Surgical Systems and Technology • Multi-institution, multi-disciplinary center – Johns Hopkins University + Medical Institutions – MIT + Brigham & Women’s Hospital – CMU + Shadyside Hospital • University researchers, clinicians, industry • Research, Systems, Education, Outreach NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Medical robotics and CIS Systems • Surgical CAD/CAM Preoperative Intraoperative Systems Computer- Update Model Update Plan assisted planning Surgical CAD/CAM Patient-specific Computer- • Surgical Assistant Model Assisted Execution Systems Postoperative Atlas Computer - Assisted Assessment • Concluding remarks Patient Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000 NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 5 Orthopaedic Surgical CAD/CAM Example: Joint Replacement Surgery Photo: courtesy Brian Davies NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Urologic Surgical CAD/CAM Example: Robotic TURP Photo: courtesy Brian Davies NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 6 Optimized Local Therapy • Deliver optimized patterns of local treatments (e.g., radiation seeds, injections) with an image-guided robot • Applications – Prostate, brain, spine, liver, bone, kidney …. Photo: D. Stoianovici, L. Kavoussi • Advantages – Accuracy of dose – Cost and time of procedure – Lower morbidity – Avoid complications – Enable new treatments NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Example: Stereotactic Neurosurgery Neuromate (ISS) IGOR (Lavallee, Troccaz, et al) NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 7 Example: Radiosurgery Accuray Cyberknife® Varian Clinac® NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Current ERC focus applications Prostate Liver Spine ~210,000 new/year Mets from colorectal $120 billion cost 25% men in lifetime 130,000 new /year 70% in lifetime 60,000 death /year ~30-40% prostatectomy ~20% radiation seeds ~30-40% extracapsular NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 8 One endpoint: 1-stop shopping Pre-op Image In-scanner Screening patient robotically and plan assisted treatment treatment pattern Reimage volume •Follow up •Statistics Maintain Post-op Treatment imaging •Process Log learning NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Key Enablers • Imaging – Image-based modeling & analysis – Integration of image sensors with delivery devices for guidance and monitoring – Design points set for interventions NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 9 Example: integrated MRI imaging and therapy delivery 78 µm resolution ! Beagle prostate Canine urethra Photo: E. Atalar, JHU Combined endoscopic MRI coil & RF ablator Coaxial transmission line RF electrodes LCR Surface coil Scanner E. Atalar, JHU NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Statistical atlas of prostate cancer Christos Davatzikos & Dinggang Shen • Labeled images* of 20 subjects for cancer and normal tissue • Deformably registered images to average prostate (red) • Computed spatial distribution of cancer (green) • Computed 5 needle positions to maximize probability of detection • Use statistical correlation of cancer spatial distributions to optimize pattern * Images provided by Jianchao Zeng, Georgetown U. NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 10 Key Enablers • Imaging • Robots & delivery aids – Modular designs – Compatible with imaging device – End effectors Sketch: Kirby Vosberg, Ferenc Jolesz NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Remote Center of Motion (RCM) • 2 DOF • Mechanically constrained motion center • Maintains entry site R. Taylor, D. Stoianovici, L. Whitcomb, A. Barnes NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 11 Alternate RCM implementations: Parallel linkages Goniometer arcs Davies, et al. NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Photo: D. Stoianovici, JHU Urology Dept NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 12 CT-Compatible End-Effector R. Susil , R. Taylor, J. Anderson, D. Stoianovici NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 Phantom Experiment • Standard prostate phantom • Demonstrated ~1mm accuracy with robot from single CT image targeting R. Susil , G. Fichtinger, K. Masamune, A. Patriciu, D. Stoianovici, E. DeWeese , R. Taylor NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001 13 Clinical example • Kidney biopsy • Robot registered to CT from single image using markers on end-effector Photos: D. Stoianovici, L. Kavoussi, A. Patriciu, S. Solomon (JHU Bayview) Other contributors: R. Susil, G. Fichtinger, K. Masamune, R. Taylor (JHU WSE) NSF Engineering Research Center for Computer Integrated Surgical Systems and Technology Copyright © CISST ERC, 2000, 2001
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