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The Royal Society of Edinburgh Issue 15 • Winter 2006

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The Royal Society of Edinburgh Issue 15 • Winter 2006 news THE ROYAL SOCIETY OF EDINBURGH ISSUE 15 • WINTER 2006 RESOURCE THE NEWSLETTER OF SCOTLAND’S NATIONAL ACADEMY Microcrystals promise major medical benefits A new technology being developed in Scotland could transform the treatment of many diseases by enabling protein medicines that currently need to be injected, to be taken with an inhaler. Recognising the importance of this breakthrough, Dr Marie Claire Parker was presented with the nation’s top award for innovation at a Ceremony held in the Royal Museum of Scotland on 27 October 2006. Dr Parker is CEO of XstalBio Ltd, a University of Glasgow and University of Strathclyde spin-out company, which developed as a result of an RSE/Scottish Enterprise Enterprise Fellowship held by Dr Parker in 2001. The Gannochy Trust Innovation Award of the Royal Society of Edinburgh has been created to encourage and reward Scotland’s young innovators for work which benefits Scotland’s wellbeing. This coveted award also carries a cheque for £50,000 and a specially commissioned gold medal, which was presented to Dr Parker by the President of the RSE, Sir Michael Atiyah. Dr Parker plans to use the £50,000 award to help develop the manufacturing process of stable, cost-effective vaccines and the advancement of a high quality biotechnology manufacturing company in Scotland, boosting our economy. Events around Scotland Christmas Lecture 2006 International Exchanges Recognising Excellence GANNOCHY TRUST INNOVATION AWARD OF THE ROYAL SOCIETY OF EDINBURGH Entitled “Protein-coated Microcrystal (PCMC) Technology”, Dr Parker’s new process can attach proteins such as insulin to crystals that are so tiny (between one and five thousandths of a millimetre) that they can be inhaled, allowing the drug to enter the body via the lung. Whilst it must be emphasised that the technology is still to be clinically tested, it could enable some people with certain types of diabetes to avoid inconvenient, painful injections by taking their medicine with an inhaler. This technology is therefore likely to increase the consistency of the medicine being taken and so improve control of blood- sugar levels. Protein and peptide drugs, so called biopharmaceuticals, normally have to be injected because in pill form they are destroyed in the gut by the body’s own naturally-occurring acids. There are believed to be over 200,000 people in Scotland with diabetes and numbers are predicted to increase dramatically1*. The World Health Organization states that at least 171 million people worldwide have diabetes and estimates that this figure is likely to more than double by 2030 to reach 366 million2*. PCMC Technology has the potential to create a new generation of therapeutic drugs and therapeutic vaccines that would significantly improve the treatment of chronic and acute diseases in Scotland and around the World. Because the crystals engineered by Dr Parker are stable at temperatures as high as 400C, the technology could be of particular benefit to people in countries where refrigeration of medicines is difficult. XstalBio Ltd recently signed a licensing agreement with Europe’s largest manufacturer of therapeutic proteins, Boehringer Ingelheim. One outcome of this agreement will be the construction of a GMP manufacturing plant capable of producing large quantities of sterile PCMC suitable for clinical trials The company has also entered into a collaboration with Avecia to develop vaccines that can be used to combat bioterrorism. Dr Parker has so far focused on healthcare and, in particular, formulation and drug-delivery, but the innovation also has applications in a wide range of other areas, including diagnostics and cosmetics. The Gannochy Trust’s Chairman, Dr 1*Source: Diabetes in Scotland (NHS Scotland) 2*Source: http://www.who.int/diabetes/en/ Russell Leather (pictured below) said: Reacting to the announcement, Dr Parker said: The Gannochy Trust recognises the I am delighted and exceptionally honoured to receive what is a highly prestigious enormous potential of Dr Parker’s award; The Gannochy Trust Innovation Award of the Royal Society of Edinburgh for innovation to offer very significant 2006. The award will provide a wonderful mark of recognition for the PCMC healthcare benefits to people in Scotland Technology, both for myself and XstalBio, not only in Scotland but also globally. With and abroad. I am delighted that we can this award we intend to develop our manufacturing process further for the cost- support and encourage the best of our effective and efficient production of stabilised vaccines and to continue to market the young innovators through this technology globally. partnership with the RSE. I wish Dr Parker and her colleagues every success in transforming their technology into life- RSE President, Sir Michael Atiyah said: enhancing and life-saving medicines. This innovation has the potential to transform the treatment of many diseases. If clinical trials prove successful, this technology could improve the quality of life of many and save countless lives by enabling vaccines to be provided in countries where refrigeration is difficult. I am delighted that, as a result of the Gannochy Trust’s generous support, we are able to recognise Dr Parker’s achievement. I offer my congratulations to Dr Parker and commend her ingenuity, dedication and hard work. 2 President’s Perspective I recently attended an informal meeting held at the Royal Society in London which brought together the Presidents and Chief Executives of five UK academies: The Royal Society, the British Academy, the Royal Academy of Engineering, the Academy of Medical Sciences and the Royal Society of Edinburgh. The purpose of the meeting was to discuss ways in which we could act more effectively together on matters which straddle all fields, climate change being a high-profile example. In particular we considered the merits of joint approaches to the Government, speaking with a united voice on important and topical issues. Lord Browne, the incoming President of the Royal Academy of Engineering, brought the perspective of industry, while the RSE, operating on the smaller canvas of Scotland, illustrated the way in which science, medicine, engineering and the arts can all be fruitfully integrated. We agreed to carry on the dialogue between our academies in a variety of ways, and to exchange experience from both sides of the border. Sir Michael Atiyah, OM, FRS, PRSE, HonFREng, HonFMedSci, HonFFA DEBATING SCOTLAND’S ENERGY CHOICES Following the publication of the RSE’s Inquiry Report into Energy Issues for Scotland, the RSE is planning to hold a series of countrywide events to engage as wide a range of The Royal Society of Edinburgh (RSE) society as possible to debate the issues and to help better inform the decisions that is Scotland’s National Academy of need to be taken.This will culminate in a final conference in Edinburgh in April 2007. Science & Letters. It is an independent body with charitable status. The The first public events in the series were held at the University of Aberdeen on the 24th Society organises conferences and October and comprised a discussion forum for S5 and S6 students in the Linklater lectures for the specialist and for the Rooms during the general public. It provides a forum for day and a public informed debate on issues of national discussion forum in and international importance. Its the King’s College multidisciplinary fellowship of men Auditorium in the and women of international standing evening. provides independent, expert advice Professor Maxwell to key decision-making bodies, including Government and Irvine DL FRSE, Parliament. Professor Roger The Society’s Research Awards Crofts CBE FRSE programme annually awards well over and Dr Malcolm £1.7 million to exceptionally talented Kennedy CBE FRSE, young academics and potential along with Mr entrepreneurs to promote commercial Graham Shanks, exploitation of inventiveness and Chief Executive of boost wealth-generation. Satrosphere Science Centre in Aberdeen, participated in the students’ discussion forum Among its many public benefit which focused on issues relating to energy supply, energy efficiency, saving, research activities, the RSE is active in and development, as well as the role of government and public awareness. Professor classrooms from the Borders to the Crofts chaired a panel comprising Professor Irvine, Mr Iain Todd from Aberdeen Northern Isles, with a successful Renewable Energy Group and Mr Nial McCollam, Chief Executive of ITI Energy for the programme of lectures and hands-on public discussion forum. Around fifty people from industry, local government, academia workshops for primary and secondary school pupils. and the public attended the evening event and a lively debate of the issues ensued. Further events will be organised around Scotland next year. For details see the RSE web The Royal Society of Edinburgh, working as part of the UK and within page at http://www.royalsoced.org.uk/events/energy.htm a global context, is committed to the future of Scotland’s social, economic and cultural well-being. 3 Scotland’s Research Talent AWARDEES 2006 In addition to the awards announced in the last newsletter, the following awards were also made at the Annual Awards Ceremony on 29 September 2006 at the Royal Society of Edinburgh: Lloyds TSB Foundation for Scotland CRF European Travel Fellowships – CRF European Travel Fellowship – Research Studentship Visits to Scotland Visits to Europe Miss Katie L Blackett Dr Guido Alfani Maria Fletcher Bacteria in the pathogenesis
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