ABCD springer.com Just Released New Books August 2010 All Titles - English, German, Italian Sorted by author and title within the main subject springer.com Biomedicine 2 I. Ahmad, Department of Agricultural Microbiology, Aligarh Mus- N. Beauchemin, Goodman Cancer Research Centre, McGill Uni- Biomedicine lim University, Aligarh, India; M. Owais, Interdisciplinary Biotech- versity, Montreal, Qc, Canada; J. Huot, Le Centre de recherche nology Unit, Aligarh Muslim University, Aligarh, India; M. Shahid, en cancérologie de l’Université Laval et Centre de recherche du Department of Agricultural Microbiology, J.N. Medical College, CHUQ, l’Hôtel-Dieu de Québec, Québec, Canada (Eds.) Aligarh Muslim University, Aligarh, India; F. Aqil, Brown Cancer A. Abendroth, University of Sydney, Camperdown; A.M. Arvin, J.F. Center, University of Louisville, USA (Eds.) Moffat (Eds.) Metastasis of Colorectal Cancer Combating Fungal Infections Varicella-zoster Virus Problems and Remedy Colorectal cancer is the third most common can- cer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related Varicella-zoster virus is a common human pathogen deaths. This book covers colon cancer metasta- that causes varicella (chickenpox), establishes latency The currently available means of combating fungal sis from the most fundamental aspects to clinical in sensory nerve ganglia and can reactivate many infections are weak and clumsy. The application of practice. Major topics include physiopathology, years later as herpes zoster. VZV is the only human fungal genomics offers an unparalleled opportunity genetic and epigenetic controls, cancer initiating herpesvirus for which vaccines to prevent both pri- to develop novel antifungal drugs. Interestingly, sev- cells, epithelial-mesenchymal transition, growth fac- mary and recurrent infection are approved and VZV eral novel antifungal drug targets have already been tors and signalling, cell adhesion, natures of liver vaccines have had significant public health bene- identified and validated. However, it is premature to metastasis, angiogenesis and lymphangiogenesis, fits. These achievements and new directions that are expect a novel antifungal agent in clinical setting as inflammatory response, prognostic markers, sentinel unfolding are described in this review of VZV basic drug discovery programs are still in their infancy. In node and staging, and finally diagnosis and treat- and clinical research addition to classical and genomic approaches to drug discovery, treasure trove based on natural products ment. Each chapter has been contributed by leaders Features and phytomedicine can provide a multitude of alter- in the field. A key feature is that it connects with a Varicella-zoster virus is a common human pathogen native modes of combating fungal infection. This large readership including students, fundamentalists that causes varicella (chickenpox), establishes latency book incisively addresses essential topics on vari- and clinicians. Another specific feature of the book in sensory nerve ganglia and can reactivate many ous aspects pertaining to fungal diseases in human is that the chapters are written in a didactic and illus- years later as herpes zoster. Although the VZV and animals, their reservoir, fungal pathogenesis, trative fashion. These characteristics coupled with genome is the smallest of the human herpesviruses, their management and recent advances in their treat- the choice of the topics and authors, makes this book VZV genes encode at least 70 proteins. Molecu- ment. Issues of antifungal drug toxicity, especially a reference in the field. It represents[..] lar epidemiologic approaches based on genomic nephrotoxicity, are also discussed. The development Features sequencing have documented the global distribution of resistance in fungal pathogens, including mul- Colorectal cancer is the third most common can- of VZV in [..] tidrug resistance and its[..] cer worldwide, and in many parts of the western Fields of interest Features world, it is the second leading cause of cancer-related Virology The currently available means of combating fungal deaths. This book covers colon cancer metasta- infections are still weak and clumsy. The application sis from the most fundamental aspects to clinical Target groups of fungal genomics offers an unparalleled opportu- practice. Major topics include physiopathology, Research nity to develop novel antifungal drugs. Interestingly, genetic and epigenetic controls, cancer initiating several novel antifungal drug targets have already cells, epithelial-mesenchymal transition, growth [..] Type of publication been identified and validated. However, it is too early Contents Monograph to expect any novel antifungal drug as drug discovery 1. The Metastatic Process: an Overview; 2. Phys- programs are still in their infancy. In [..] Available iopathology of Colorectal Metastasis; 3. The Genetic Contents of Colorectal Cancer; 4. Epigenetics of Colorectal Mould Infections: A global Threat to Immuno- Cancer; 5. Cancer-initiating Cells in Colorectal Can- 2010. XII, 360 p. 68 illus., 34 in color. (Current Topics in Microbiol- cer; 6. Epithelial-Mesenchymal Transition in Col- ogy and Immunology, Vol. 342) Hardcover compromised Patients.- Virulence and Pathogenic- ity of Fungal Pathogens with Special Reference to orectal Cancer; 7. Cell Adhesion Molecules in Colon 149,95 € Candida albicans.- Animal as Reservoir of Fungal Cancer Metastasis; 8. Epithelial Cell Signalling in ISBN 978-3-642-12727-4 Diseases (Zoonoses).- Fungi Associated with Eye Colorectal Cancer Metastasis; 9. Angiogenesis and Infections with Special Reference to Corneal Kerati- Lymphangiogenesis in Colon Cancer Metastasis; 10. tis and Their Possible Reservoir.- Antifungal Drugs: Role of the Host Inflammatory Response in Colon Mode of Action and Recent Development.- Antifun- Carcinoma Initiation, Progression and Liver Metas- gal-induced Nephrotoxicity in Pediatrics: A State of tasis; 11. Molecular Prognostic Markers in[..] Art.- Antifungal Resistance: Cellular and Molecular Fields of interest Mechanisms.- Multidrug Resisitance in Fungi: Role Cancer Research; Oncology; Molecular Medicine; of Pleiotropic Drug Resistance Genes.- Laboratory[..] Antibodies; Pathology Fields of interest Target groups Medical Microbiology; Microbiology; Immunology; Research Pharmacology / Toxicology Type of publication Target groups Contributed volume Research Type of publication Available Monograph 2010. XVI, 416 p. (Cancer Metastasis - Biology and Treatment, Vol. Available 14) Hardcover 169,95 € 2010. XX, 539 p. 42 illus., 21 in color. Hardcover ISBN 978-90-481-8832-1 169,95 € ISBN 978-3-642-12172-2 springer.com Biomedicine 3 O. Bruserud, University of Bergen, Norway (Ed.) S. Choi, Ajou University, Suwon, Korea (Ed.) K. Clément, Pitié Salpetrière Hospital, Paris, France; B.M. Spiegel- man, Harvard Medical School, Boston, MA, USA; Y. Christen, Fon- dation IPSEN, Boulogne-Billancourt, France (Eds.) The Chemokine System in Systems Biology for Signaling Experimental and Clinical Networks Novel Insights into Adipose Cell Hematology Functions System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunol- The aim of the issue is to describe and explain the ogy, Genetics, Computational Biology, Mathematical Obesity is a disease of society and economic tran- importance of the chemokine system in hematol- Biology, etc. not only to address key questions that sition spreading at an epidemic pace throughout ogy. The chemokine system is probably important are not answerable by individual fields alone, but the world. According to the World Health Organi- for many aspects of normal as well as malignant also to help in our understanding of the complexi- zation, obesity is defined as an increased or abnor- hematopoiesis. A major focus is the development ties of biological systems. Whole genome expression mal accumulation of body fat mass to the extent that and treatment of hematologic malignancies, includ- studies have provided us the means of studying the individual’s health will be negatively affected. Over- ing the immunobiology of stem cell transplantation. expression of thousands of genes under a particular weight is thus being considered as top at risk condi- The present reviews illustrate that chemokines can condition and this technique had been widely used tion in the world and it is mandatory to identify the be involved in leukemogenesis. The chemokine sys- to find out the role of key macromolecules that are physiopathological causes involved in adipose tis- tem is also important both for the crosstalk between involved in biological signaling pathways. However, sue enlargement and related metabolic and cardio- malignant cells and their neighbouring nonmalig- making sense of the underlying complexity is only vascular health disorders.This volume provides the nant stromal cells (including endothelial cells) as possible if we interconnect various signaling path- most up to date insights into the biology of a com- well as for immunoregulation in patients treated ways into human and computer readable network plex endocrine organ: the adipose tissue. with allogeneic stem cell transplantation. Thus, maps. These maps can then be used to classify and chemokines are important both for the pathogenesis Features study individual components involved in a particular and treatment of hematological diseases. Obesity is considered as top at risk condition in phenomenon. Apart from transcriptomics,