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A Panorama of Scientific Research at Bar-Ilan University A Panorama Of Scientific Research at Bar-Ilan University Office of the Vice President for Research | Research Authority Table of Contents Introduction 3 Faculty of Exact Sciences 4 Mina & Everard Goodman Faculty of Life Sciences 36 Faculty of Engineering 51 Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA) 60 Faculty of Medicine in the Galilee 63 Faculty of Jewish Studies 67 Faculty of Humanities 100 Faculty of Social Sciences 126 Faculty of Law 182 Interdisciplinary Programs 190 List of Researchers 200 2 | Office of the Vice President for Research | Research Authority Introduction The pages of this impressive Panorama of Research book offer a glimpse into the far-reaching spectrum of research activity undertaken by the scholars and scientists of Bar-Ilan University. The content reflects, not only the diverse interests of the faculty members, but also, the demographic diversity of the community itself, - men and women, senior and junior academics, new immigrants and native Israelis, and home grown and returning scientists. The full panoply of faculty members, synergizes to produce the remarkable scientific output of Bar-Ilan University. This is an apt opportunity to note the sea-change that has been taking place in BIU’s academic composition, particularly with reference to the significant effect wrought on the quality and quantity of research being produced in the University. Originally established as a largely liberal arts institution with Jewish Studies, Humanities, Law and Social Sciences as the majority partners, over the past decade there have been concerted efforts to shift the balance between the arts and sciences to allow for a more equitable division between the two disciplines. With the addition of Engineering and Medical faculties together with the Exact and Life Sciences, we now are beginning to see the fruits of this policy change in the significant increase in external research funding. Particularly exciting is the close collaboration forged between the different specialities, through inter- and multi-disciplinary research. Evidence for this can be seen in the hallways and labs of the Gonda Brain Research Center and the Gonda Nanotechnology Complex. These two initiatives allowed the University to provide laboratories for the best and brightest researchers recruited from the most prestigious universities around the world. The University’s commitment to not only absorb these new faculty members, but also to provide them with state-of-the-art equipment, start-up funding, and technicians, has resulted in a meteoric rise in research income. The effects of Bar-Ilan University’s focus on faculty development can also be seen in the human sciences, where the range of research being conducted has been enhanced, with a concomitant increase in the number of prizes and awards being bestowed on faculty, helping to create an intellectual culture that is producing the next generation of scholars. The Panorama of Research book is intended to open the BIU research “DNA” to potential collaborations with scientists and scholars from other universities. This is indeed a targeted effort designed to expand our global academic outreach significantly, increase the number of submissions to major granting agencies, and in general, advance our efforts to create new dynamic partnerships with colleagues and institutions in Israel and abroad. I invite you to peruse these pages with that goal in mind, and join with us as we strive to reach new horizons in research. Prof. Arie Zaban Vice President for Research 3 | Office of the Vice President for Research | Research Authority Faculty of Exact Sciences Department of Chemistry Department of Computer Science Department of Mathematics Department of Physics 4 | Office of the Vice President for Research | Research Authority Department of Chemistry Prof. Amnon Albeck E-mail: [email protected] Synthetic chemistry, peptides, peptidomimetics, enzyme mechanism, enzyme inhibition, proteases, drug design, computational biochemistry. Prof. Doron Aurbach E-mail: [email protected] General, electrochemical, surface and materials science. Development of novel power sources: rechargeable batteries - Li, Mg, Na and Pb based (including Li-air and Li-sulfur batteries); super-capacitors; batteries for electrical propulsion (including Al-air primary batteries), small batteries for portable sensors, batteries for sustainable energy storage and conversion. Water treatment by electrochemical means: development of electrodes and engineering of full devices for water desalination and purification. Development of novel in-situ spectro-electrochemical tools. Equipment: - electrochemical measurements by multi-channel computerized systems; Impedance, FTIR and Raman spectroscopies, XPS, solid-state NMR; surface analysis by gas adsorption; electrochemical quartz crystal microbalance and admittance and microscopy, including surface conductivity measurements; thermal analysis by DSC, accelerating rate calorimeter, and thermo-gravimetric analysis; tunneling electron microscopy, both regular and high resolution, element analysis by ICP. Keywords: Electrochemical, Surface and materials science. Prof. Gerardo Byk E-mail: [email protected] Novel biocompatible nanoparticles for live cell and in vivo applications for imaging, cell tracking, targeting, and diagnostics. Development of Nano metric non-viral gene delivery systems for gene therapy. Total synthesis of analogs of biologically active compounds for treating cancer. Novel multicomponent reactions for the synthesis of new compounds with biological activity. Keywords: Combinatorial chemistry, Nanobiotechnology, Tissue targeting, Tumor targeting. 5 | Office of the Vice President for Research | Research Authority Department of Chemistry Prof. Jordan Chill E-mail: [email protected] The structure, dynamics and function of proteins, folded and unstructured, with applications for structure-guided drug design, employing high-resolution NMR. Specific projects include: interaction of potassium channels with ligands and inhibitors and formation of the E1/E2 glycoprotein complex needed for hepatitis C virus infectivity. Equipment: - Nuclear magnetic resonance spectrometer-700 MHz equipped with cryoprobe; protein expression and purification facility - from gene to sample. Keywords: protein structure, membrane associated proteins. Dr. Lior Elbaz E-mail: [email protected] Fuel Cells, Electrochemistry, Electro catalysis, Oxygen reduction, Hydrogen Oxidation, Design and synthesis of transition metal complexes, Ceramic catalyst supports, Functionalized carbons, Bio-inspired catalytic systems, Electron transfer mechanisms, Metal-air batteries, Solar cells. Prof. Bilha Fischer E-mail: [email protected] Medicinal chemistry, nucleotide chemistry, drug development, siRNA, diagnostic probes Alzheimer’s disease, inflammatory bowel diseases, osteoarthritis, glaucoma. Expertise in nucleotide, dinucleotide, oligonucleotide synthesis, ectonucleotidases, nucleotide receptors, and fluorescent probes. Prof. (Em.) Aryeh Frimer E-mail: [email protected] Active oxygen chemistry within liposomal bilayers and bio membranes. 6 | Office of the Vice President for Research | Research Authority Department of Chemistry Prof. (Em.) Aharon Gedanken E-mail: [email protected] Antibacterial, antiviral and antifungal nanoparticles, sonochemical deposition of nanoparticles on surfaces, DNA and RNA Nano spheres and their application for gene expression and gene silencing, conversion of biomass to biofuels (biodiesel and bioethanol. Conversion of Biomass to fine chemicals. Sonochemistry of molten metals Carbon dots and doping carbon dots with metallic (Ga, In, Sn, Pb, and Zn) nanoparticles. Equipment: - TGA and DSC; reflection spectrometer, IR spectrometer, microwave oven, sonicators of powers at 600-2500 W 2 roll to roll sonochemical coating machine for imparting properties to the substrate. Keywords: Nanomaterials, Sonochemistry. Dr. Gil Goobes E-mail: [email protected] Protein structure; protein adsorption, biomineralization, biophysics of mineralized tissue, DNA structure, biomaterial research, advanced battery materials. Equipment: - Solid state NMR, isothermal titration calorimetry, adsorption and surface characterization, recombinant protein expression, synthesis of proteins and peptides. Keywords: Structural biology, Nanomaterials. Prof. Ilya Grinberg E-mail: [email protected] Computational chemistry and materials science, density functional theory and molecular dynamics simulations of ferroelectrics, photovoltaics, fuel cell catalysts, transparent conducting oxides, and other functional materials. Development of analytical theories and atomistic potentials to accurately represent bonding and dynamics in complex materials. Rational design of materials with improved properties. Keywords: Computational chemistry, Materials science, Molecular Dynamics simulations, Rational design of new materials. 7 | Office of the Vice President for Research | Research Authority Department of Chemistry Dr. Arie-Lev Gruzman E-mail: [email protected] Medicinal chemistry. Development of new drugs against diabetes, ALS, and prostate cancer. Prof. (Em.) Alfred Hassner E-mail: [email protected] Development of new carbon-carbon bond forming reactions in organic chemistry. Heterocyclic chemistry, Anti-cancer agents. Prof. (Em.) Shmaryahu Hoz E-mail: [email protected] Reaction mechanism and the role of additives in the chemistry of SmI2, computational chemistry on mechanical
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