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“Joy” Winuthayanon, Bs.N., Ph.D

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“Joy” Winuthayanon, Bs.N., Ph.D WIPAWEE “JOY” WINUTHAYANON, BS.N., PH.D. School of Molecular Biosciences Center for Reproductive Biology College of Veterinary Medicine Washington State University Biotechnology Life Science Building, Pullman, WA 99164 509.335.8296 | [email protected] | https://labs.wsu.edu/winuthayanon EDUCATION 2003-2009 Ph.D. Human Physiology Mahidol University, Bangkok, Thailand Doctoral Program in the Department of Physiology, Faculty of Science Evaluation and characterization for the estrogenic activity of diarylheptanoids from Curcuma comosa PI: Pawinee Piyachaturawat, Ph.D. 1998-2002 B.Sc. Nursing Science (Second Class Honors) Mahidol University, Bangkok, Thailand School of Nursing, Faculty of Medicine Ramathibodi Hospital Specialty: Nursing and Midwifery POSITIONS effective 07/2021 Associate Professor (Tenured) School of Molecular Biosciences, College of Veterinary Medicine, Washington State University (WSU), Pullman, WA Training Faculty, MARC-WSU Program (05/2021–present) Graduate Faculty, adjunct (05/2020–present) Clinical & Translational Sciences, Dept. of Veterinary Clinical Sciences, WSU Faculty Research Mentor (06/2018–present) Pacific Northwest Louis Stokes Alliance for Minority Participation (LSAMP), WSU Faculty Research Mentor (01/2016–present) Team Mentoring Program (TMP), WSU 08/2015–06/2021 Assistant Professor School of Molecular Biosciences, College of Veterinary Medicine, WSU 08/2009–07/2015 Post-doctoral Fellow National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS), Research Triangle Park (RTP), NC Reproductive & Developmental Biology Laboratory PIs: Kenneth Korach, Ph.D. and Carmen Williams, M.D. Ph.D. 03/2007–06/2008 Pre-doctoral Fellow NIH/NIEHS, Research Triangle Park, NC Laboratory of Reproduction and Developmental Toxicology PI: Kenneth Korach, Ph.D. 06/2003–01/2009 Graduate Research Assistant Department of Physiology, Faculty of Sciences, Bangkok, Thailand PI: Pawinee Piyachaturawat, Ph.D. 05/2002–03/2003 Registered Nurse Orthopedics Unit, Ramathibodi Hospital, Bangkok, Thailand Surgery Unit, Phyathai Hospital, Bangkok, Thailand Curriculum vitae | Wipawee “Joy” Winuthayanon | Updated on 5.18.2021 1 AWARDS & HONORS 09/2020 Dean’s Outstanding Junior Faculty Award, College of Veterinary Medicine, WSU 04/2020 Excellence in Undergraduate Mentor Award, School of Molecular Biosciences, WSU 10/2019 Winner of WSU Largest New Individual Grant Award for FY 2019 01/2017 J Molecular Endocrinology’s 2nd most downloaded review article of the year (for 2016) 01/2017 J Endocrinology’s most downloaded review article of the month 02/2015 Research article selected by NIEHS Intramural Research Division as “paper of the month” 02/2014 NIH Cross-Divisional Group Merit Award, NIEHS, NIH 06/2013 Winner of Presidential Poster Competition, The Endocrine Society Meeting 06/2013 Research article selected by NIEHS Intramural Research Division as “paper of the month” 06/2012 Outstanding Abstract Award, The Endocrine Society Meeting 10/2011 Winner of the Fellows Awards for Research Excellence (FARE), NIH 02/2011 Research article highlighted in NIEHS Environmental Factor as "work of great interest" 01/2011 Research article selected by NIEHS Assembly of Scientists as “paper of the month” 2005–2009 Scholarship, the Royal Golden Jubilee PhD Program, Thailand Research Fund RESEARCH ACTIVITIES • Steroid hormones action in the female reproductive tract during pregnancy establishment • Semen liquefaction: a novel target for women-controlled contraceptive products GRANT AND FELLOWSHIP SUPPORT Since joining WSU, I have been awarded an R01 research grant from NIH (R01HD097087; $1,062,500 direct costs) and two NIH Diversity Supplement Awards (R01HD097087-01S1 and R01HD097087-02S1; $26,431 and $88,288, respectively). Although X01HD104425 and HD106634 awards do not result in a direct cost, the actual cost for the project (at least $169,911) is paid for by the NIH. Moreover, the findings from these research projects will likely lead to a patent for a novel contraceptive drug development. In total, my research program has been awarded $1,177,219 of direct costs by the extramural funding. Current 1. R01 HD097087 – NIH/NICHD Role: PI 03/12/19 – 02/29/24 The actions of steroid hormones on oviduct function Direct cost: $1,062,500 2. R01 HD097087-02S1 diversity supplement – NIH/NICHD Role: PI 05/15/20 – 05/14/22 The actions of steroid hormones on oviduct function (to Emily Harris) Direct cost: $88,288 3. X01 HD104425 – NIH/NICHD Role: PI 07/01/20 – 06/30/21 Synthesis and optimization of KLK3 inhibitors for novel contraceptive purposes Direct cost: N/A – This is a service request to the Chemical Screening & Optimization Facility Contract cost to SRI International paid for by the NICHD. Not searchable in the NIH RePORTER. 4. X01 HD106634 – NIH/NICHD Role: PI 04/01/21 – 03/31/22 Screening to identify novel inhibitors of KLK3 from established chemical libraries for contraceptive drug discovery Direct cost: N/A – This is a service request to the Chemical Screening & Optimization Facility Not searchable in the NIH RePORTER. Pending 5. R01 HD102345-01A1 – NIH/NICHD Role: admin PI 05/01/21 – 04/31/26 Disruption of semen liquefaction using protease inhibitor as a new contraceptive Direct cost: $3,544,540 25th percentile mPI: Martin Matzuk (Baylor College of Medicine) mPI: Ov Slayden (Oregon Health Science University, Oregon National Primate Research Center) Curriculum vitae | Wipawee “Joy” Winuthayanon | Updated on 5.18.2021 2 6. F31 HD107807 Diversity – NIH/NICHD Role: Sponsor 09/01/21 – 08/31/23 The role of progesterone receptor in the oviduct epithelium for pregnancy establishment Direct cost: $29,862 PI: Emily Harris (McGlade), graduate student Completed 7. R01 HD097087-01S1 diversity supplement – NIH/NICHD Role: PI 09/01/19 – 08/31/20 The actions of steroid hormones on oviduct function (to Gerardo Herrera) Direct cost: $26,431 8. WSU College of Veterinary Medicine Research Grant Role: PI 08/01/17 – 07/31/19 A novel contraceptive drug targeting semen liquefaction Direct cost: $20,000, intramural 9. WSU Center for Reproductive Biology Internal Seed Role: PI 09/01/17 – 08/31/19 Generation of Ovgp1Cre targeted knock-in mouse model using CRISPR/Cas9 technology Direct cost: $10,000, intramural 10. WSU New Faculty Seed Grant Role: PI 05/16/16 – 02/16/18 Identification of cell-type selective transcriptome regulation by hormones in the oviduct Direct cost: $15,000, intramural Not funded, or Letters of intent/pre-proposal submitted but not invited for a full application 11. R01 HD102345 – NIH/NICHD (02/2020) Role: admin PI Not discussed Disruption of semen liquefaction using protease inhibitor as a new contraceptive 12. R01 HD098103-01A1 – NIH/NICHD (06/2020) Role: co-I, 10% effort 17th percentile Functional Analysis of Adult Endometrial Epithelial Stem Cells PI: James Pru, Department of Animal Sciences, WSU 13. R61 HD099744 – (R61/33) NIH/NICHD (11/2018) Role: PI Not discussed Disruption of semen liquefaction using protease inhibitor as a new contraceptive 14. R01 HD097087-01A1 – NIH/NICHD (07/2018) Role: PI Withdrawn The actions of steroid hormones on oviduct function 15. NSF CAREER: 1843053 – NSF (07/2018) Role: PI Not funded CAREER: Steroid Hormones and the Function of the Oviduct 16. LOI: Beckman Young Investigator Award– Arnold Beckman Foundation (08/2017) Role: PI Semen liquefaction: Novel target for contraceptive method Not invited for full application 17. R01 AI123549-01A1– NIH/NIAID (06/2017) Role: co-I, 5% effort 31st percentile Chlamydia interactions with epithelial cells PI: Rey Carabeo (School of Molecular Biosciences, WSU) 18. R21 HD094394 – NIH/NICHD (02/2017) Role: PI Not discussed In Vivo Regulation of Semen Liquefaction by the Female Reproductive Tract 19. R21 HD090195 – NIH/NICHD (02/2016) Role: PI Not discussed Kallikreins in female reproductive tract: new players in semen liquefaction 20. Pre-proposal: Pew Scholars in Biomed Sci (06/2015) Role: PI Not selected for full app. Roles of estrogen and progesterone during embryo development & transport in the oviduct 21. K99 HD081156 – NIH/NICHD (03/2014) Role: PI Impact score = 24 Hormonal effects on oviductal ciliated cell function and embryo transport Curriculum vitae | Wipawee “Joy” Winuthayanon | Updated on 5.18.2021 3 PUBLICATIONS [Citations number] Google Scholar total 823 citations, h-index = 14, i10-index = 17 Primary research papers (*Corresponding author) 1. McGlade EA, Herrera GG, Stephens KK, Olsen SLW, Winuthayanon S, Guner J, Hewitt SC, Korach KS, DeMayo FJ, Lydon JP, Monsivais D, and Winuthayanon W*. (2021) Cell-type specific analysis of physiological action of estrogen in mouse oviducts. FASEB J. 35;e21563. [1] 2. Hewitt SC, Carmona M, Foley G, Donoghue LJ, Lierz SL, Winuthayanon W, and Korach KS. (2020) Peri- and post-pubertal estrogen exposures of female mice optimize uterine responses later in life. Endocrinology. 161: 1-12. [1] Selected for the commentary on Endocrinology 3. Griffiths R, Pru C, Behura S, Cronrath A, McCallum M, Kelp N, Winuthayanon W, and Pru K. (2020) AMPK is required for uterine receptivity and normal responses to steroid hormones. Reproduction. 159: 707-717. [2] 4. Barton BE, Rock JK, Willie AM, Harris EA, Herrera GG, Anamthathmakula P, and Winuthayanon W*. (2020) Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice. Biol Reprod. 103: 400-410 [2] 5. Herrera GG, Lierz SL, Harris EA, Donoghue LJ, Hewitt SC, Rodriguez, KF, Jefferson WN, Lydon JP, DeMayo FJ, Williams CJ, Korach KS, and Winuthayanon W*. (2020) Oviductal retention of embryos in female mice lacking estrogen receptor a in the isthmus and the uterus. Endocrinology. 161: 1-12. [1] 6. Li S, Beedle M-T, Herrera GG, Tam KK, and Winuthayanon W*. (2019) Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice. Mol Reprod Dev 86: 611-613. 7. Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, and Korach KS. (2019) Negative elongation factor is essential for endometrial function. FASEB J. 33: 3010-3023. [1] 8. Li S, Herrera GG, Tam KK, Lizarraga JS, Beedle M-T, and Winuthayanon W*.
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