DOCSLIB.ORG

Annual Report of the Chief Medical Officer 2016, Generation Genome London: Department of Health (2017)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Annual Report of the Chief Medical Officer 2016, Generation Genome London: Department of Health (2017) A T G C T G A C T C C A G T A A G A A T G C A C T C C A G T A A G G A A T G C T A C T C C A T C G A T G C T G A T C C A G T A A G A G A G G A A T G G T A A G A A T G C C C A G G T A A G A A T C G A T G C T G A C T C A G T C G A T G C T G A C C C A G T A A G A A T G G A A T G C T A C T C C A G T T G C C A G A A T G G T A A G A A AnnualT G C ReportC T G ofC theC C A G G A A T C G A T G C T ChiefG A CMedicalT C A OfficerG G A 2016A T C T C A G G A A T G G T G A T C C A G T A A A C T C C A G T A A G G A A T G C T A C T C T G C T G A T C C A G T A A G A A T G C C A A T G C T G A C T C C GenerationA G T A GenomeA G A A T G C A C T C C A G T A A G G A A T G C T A C T C C A T C G A T G C T G A T C C A G T A A G A G A G G A A T G G T A A G A A T G C C C A G G T A A G A A T C G A T G C T G A C T C A G T C G A T G C T G A C C C A G T A A G A A T C A T C G G A A T C G A T G A A T C G A T A T A A G A A T C G A T G C T G T G A C T C A A C T C C A G T G A A T C G A T C T A C T C C A T C G A T G C T G A T C C A G T A A G A G A G G A A T G G T A A G A A T G C C C A G G A A G E N E R A T I O N G T G T G A C T C A T G C C C A G T A T G G E N O M E C T C A A C T C C A G T A A G G A A T G C T A C T C C A T C G A T G C T G A T C C A G T A A G A G A G G A A T G G T A A G A A T G C C C A G G T A A G A A T C G A T G C T G A C T C A G T C G A T G C T G A C C C A G T A A G A A T A A T G G T A A G A A T G C A G A A T G C C C A G T A A G A A T G C G A A T G C T A C T Foreword I publish my annual report on health in England as part of my statutory role. In this edition of my report, I take a detailed look at genomics, exploring how we currently utilise genomics in our health and care system and how its potential may be developed. Leading figures from the field of genomics have contributed specialist chapters. I include topics such as the care and treatment of cancer, diagnosing rare diseases, the use of genomics in screening and ‘personalised’ prevention, precision medicine – the targeting of drugs to do the most good and least harm. I wanted also to consider genomics within the context of society and include a chapter considering the ethical and societal discourse around genomics. Using the evidence I make recommendations, aimed at those able to bring about change, to guide how our potential can be realised to both improve patients’ outcomes and maintain the UK’s leadership role in genomics. Genomics is not tomorrow. Its here today. I believe genomic services should be available to more patients, whilst being a cost-effective service in the NHS. This is exciting science with the potential for fantastic improvements in prevention, health protection and patient outcomes. Now we need to welcome the genomic era and deliver the genomic dream! Prof Dame Sally C Davies Annual Report of the Chief Medical Officer 2016, Genomics Foreword page 1 Annual Report of the Chief Medical Officer 2017, Genomics Foreword page 2 Editors and authors Annual Report of the Chief Medical Officer 2016, Genomics Editors and authors page 3 Editors and authors This report could not have been produced without the Chapter 3 Genomics and theraputics generous input of the following people. Chapter lead Munir Pirmohamed Editor-in-Chief Institute of Translational Medicine, University of Liverpool Claudia Langenberg MRC Epidemiology Unit, University of Cambridge Chapter 4 Developing medicines targeting severe genetic diseases Policy Adviser Chapter lead Mark Bale David Altshuler Genomics England and Department of Health Vertex Pharmaceuticals Project Manager and Editor Chapter 5 Cancer diagnosis Orla Murphy Chapter lead Ultan McDermott Department of Health Wellcome Trust Sanger Institute Chapter 6 Rare diseases Chapter Authors Chapter lead Patrick Chinnery Chapter 1 Chief Medical Officer’s summary Cambridge University Hospitals NHS Trust, University of Cambridge Chapter lead Sally C Davies Chapter authors Patrick Chinnery, Cambridge University Hospitals NHS Trust, Department of Health University of Cambridge. Alastair Kent, Genetic Alliance UK Chapter 2 100,000 Genome Project John Bradley, Cambridge University Hospitals NHS Trust, Chapter lead and author University of Cambridge Marc Caulfield 1 Chapter authors Chapter 7 Genomics and obesity Marc Caulfield1,2, Ellen Thomas1,3 Clare Turnbull1,2 Richard Chapter lead Scott1,4 Augusto Rendon1,5 Louise Jones1,2 Kay Lawson1,6 Stephen O’Rahilly1 Nirupa Murugaesu1,7 Clare Craig1 Matina Prapa1 Simon Chapter authors Thompson1,2 Katarzyna Witkowska1,2 Laura Shallcross8 Emma Sadaf Farooqi1, Vanisha Mistry1, Stephen O’ Rahilly1 Baple1,9 Caroline Wright1,10 Katherine Smith1,2 Matthew Parker1 Ellen McDonagh1,2 Eik Haroldsdottir1 Antonio Rueda1,2 1 University of Cambridge Metabolic Research Laboratories and NIHR Damian Smedley1,2 Laura Riley1,2 Suzanne Wood1,2 Tim Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Rogers1,2 Mark Bale1,11 Lisa Dinh1 Katrina Nevin-Ridley1 Sue Metabolic Science Hill1,12 Tom Fowler1,2 Chapter 8 Personalised Prevention 1 Genomics England,London 2 William Harvey Research Institute and the Barts Cancer Institute, Chapter lead Queen Mary University of London Ron Zimmern 3 Guy’s Hospital, London 4 Great Ormond Street Hospital, London PHG Foundation 5 University of Cambridge, Cambridge 6 University College London Hospital, London 7 St George’s Hospital, London 8 UCL Institute of Health Informatics and Genomics England 9 Southampton General Hospital, Southampton 10 Wellcome Trust Sanger Institute, Hinxton 11 Department of Health, London 12 NHS England, London Annual Report of the Chief Medical Officer 2016, Genomics Editors and authors page 4 Editors and authors Chapter 9 Pathogen genomics Chapter 13 Solving Data Challenges Chapter lead Chapter editor Sharon Peacock Claudia Langenberg1 London School of Hygiene and Tropical Medicine Chapter authors Genomic data environment; Peter Counter2 Chapter contributors Bioinformatics and statistical analyses; Jessica Vamathevan,3 Eleanor Barnes, Nuffield Department of Medicine and Ewan Birney3. the Oxford NIHR BRC, University of Oxford. Judith Breuer, Clinical interpretation of genomic data; Clare Turnbull2 University College London. Miles Carroll, Public Health Lifelong electronic health records for genomic medicine; England, Porton Down. Derrick Crook, University of Oxford, Claudia Langenberg,1 Harry Hemingway4,5,6 and Public Health England. Xavier Didelot, Imperial College London. Mark Fife, The Pirbright Institute, Surrey. Andrew 1 MRC Epidemiology Unit, University of Cambridge Fox, Public Health England. Jane Greatorex, Public Health 2 Genomics England England. Ian Goodfellow, University of Cambridge. Paul 3 European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Cambridge Kellam, Imperial College London. Donald King, The Pirbright 4 Farr Institute of Health Informatics Research, University College London Institute, Surrey. Julian Parkhill, The Sanger Institute, 5 Inst itute of Health Informatics, University College London Wellcome Genome Campus, Cambridge. Tim Walker, 6 NIHR University College London Hospitals / UCL Biomedical Research University of Oxford Centre, London Chapter 10 Risk-stratified cancer screening Chapter 14 Economics of sequencing Chapter lead Chapter lead Douglas Easton John Chisholm Department of Public Health and Primary Care, and Department of Genomics England, Queen Mary University of London Oncology, University of Cambridge Chapter authors Chapter authors John Chisholm, Genomics England, Queen Mary University Douglas Easton, Department of Public Health and Primary of London.
Load more

Recommended publications
  • 100000 Genomes and Genomics England
    100,000 Genomes & Genomics England Tim Hubbard Genomics England King’s College London, King’s Health Partners Wellcome Trust Sanger Institute Global Leaders in Genomic Medicine Washington 8-9th January 2014 UK Health System 101 • Four separate health services – NHS England – NHS Wales – NHS Scotland – Health & Social Care in Northern Ireland (HSC) • NHS (England) – ~1.4 million employees – ~£110 billion annual budget • Structure in England changed 1st April 2013 https://www.gov.uk/government/organisations/department-of-health Linking Health data to Research Clinical Data Healthcare Professional World Genotype Electronic Health Record Whole Genome Sequencing Phenotype Electronic Genomic Biology Health Data World Records Reference Genotype and genome sequence Phenotype ~3 gigabytes relationship capture EBI: repositories (petabytes of genome sequence data) Human sequence data Sanger: sequencing repositories (1000 genomes, uk10K) Steps in UK towards E-Health Research, Genomic Medicine • Health data to Research – 2006 Creation of OSCHR • Increase coordination between funders: MRC and NIHR – 2007 OSCHR E-health board • Enable research access to UK EHR data • Build capacity for research on EHR data • Genomics to Health – 2009 House of Lords report on Genomic Medicine – 2010 Creation of Human Genomic Strategy Group (HGSG) 2011: UK Life Sciences Strategy No10: http://www.number10.gov.uk/news/uk-life-sciences-get-government-cash-boost/ BIS/DH: http://www.dh.gov.uk/health/2011/12/nhs-adopting-innovation/ Linking Health data to Research Clinical Data
    [Show full text]
  • Functional Effects Detailed Research Plan
    GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data.
    [Show full text]
  • Genomics England and Sciencewise Evaluation of a Public Dialogue On
    Genomics England and Sciencewise Evaluation of a public dialogue on Genomic Medicine: Time for a new social contract? Evaluation report June 2019 Quality Management URSUS Consulting Ltd has quality systems which have been assessed and approved to BS EN IS9001:2008 (certificate number GB2002687). Creation / Revision History Issue / revision: 3 Date: 19/6/2019 Prepared by: Anna MacGillivray Authorised by: Anna MacGillivray Project number: U.158 File reference: Genomics England/genomic medicine draft evaluation report 19.6.2019 URSUS CONSULTING LTD 57 Balfour Road London N5 2HD Tel. 07989 554 504 www.ursusconsulting.co.uk _________________________________________________________________________________________ URSUS CONSULTING GENOMICS ENGLAND AND SCIENCEWISE 2 Glossary of Acronyms ABI Association of British Insurers AI Artificial Intelligence APBI Association of British Pharmaceutical Industry BEIS (Department of) Business, Energy and Industrial Strategy BME Black and Minority Ethnic CMO Chief Medical Officer CSO (NHS) Chief Scientific Officer DA Devolved Administration DHSC Department of Health and Social Care FTE Full Time Equivalent GDPR General Data Protection Regulation GE Genomics England GG Generation Genome report GMS Genomic medicine service GMC General Medical Council NHS National Health Service OG Oversight Group REA Rapid Evidence Assessment SEG Socio economic group SGP Scottish Genomes Partnership SoS Secretary of State SSAC Scottish Science Advisory Committee SLT Senior Leadership Team UKRI UK Research and Innovation WGS Whole Genome Sequencing _________________________________________________________________________________________ URSUS CONSULTING GENOMICS ENGLAND AND SCIENCEWISE 3 EXECUTIVE SUMMARY Introduction This report of the independent evaluation of a public dialogue on Genomic Medicine: Time for a new social contract? has been prepared by URSUS Consulting Ltd on behalf of Genomics England (GE) and Sciencewise1.
    [Show full text]
  • Dr Sophia Skyers Director, CIBS IQ Research
    CIBS IQ Research Inclusion by Dialogue and Design 100,000 Genomes Project Black African and Black Caribbean Communities A Qualitative Exploration of Views on Participation Report Author: Dr Sophia Skyers Director, CIBS IQ Research June 2018 Acknowledgements Dr Sophia Skyers, the author, would like to thank all of the focus group participants, event attendees and radio panel members for the invaluable contribution that they have made to informing this report and to shaping its recommendations. The participation of the community and the critical exchange of views is vitally important, and projects such as these cannot be undertaken without that active engagement. The author would also like to thank Can-Survive UK, BME Cancer Communities, Genomics England, and all of the healthcare professionals, geneticists, genetics researchers, and stakeholders from a range of organisations for sharing their knowledge, experience and insights so openly, and to Dr Rohan Morris for sharing his experience on ethnicity and access in relation to clinical research. 2 Table of Contents Executive Summary 4 100,000 Genomes Project 4 1. Introduction and background 9 2. About the 100,000 Genomes Project 9 3. Purpose and approach to conducting the study 13 4. Discussion oF Findings 15 a) Interviews with stakeholders 15 b) Focus groups, awareness-raising events and media campaigns 24 5. Conclusion, synthesis and recommendations 38 Appendix A – Focus Groups 41 Appendix B – Awareness Raising Events and Radio Campaigns 42 Appendix B – Stakeholder Interviews 43 Appendix B – ReFerences 44 3 Executive Summary 100,000 Genomes Project The 100,000 Genomes Project is aiming to sequence 100,000 whole genomes from approximately 70,000 consented NHS patients in the UK with all types of cancer, and rare diseases, as well as patients’ family members, as these diseases are strongly linked to changes in the genome.
    [Show full text]
  • Sarcoma Detailed Research Plan
    GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications with expressions of interest in January 2015. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data. Domain leads are asked to complete all relevant sections of the GeCIP Detailed Research Plan Form, ensuring that you provide names of domain members involved in each aspect so we or funders can see who to approach if there are specific questions or feedback and that you provide details if your plan relies on a third party or commercial entity.
    [Show full text]
  • BMJ.2016.036140 Entitled "The Genomics England 100,000 Genomes Project" Response to Editor and Reviewer Comments
    BMJ.2016.036140 entitled "The Genomics England 100,000 Genomes Project" Response to Editor and Reviewer Comments Editors' comments 1) While editors felt that your paper covered an interesting and relevant topic, we did not feel it was a good fit for the Analysis section of the journal in its current form. Typically Analysis articles are 1800-2000 word scholarly debate articles that present a clear argument. The paper as it currently stands is too detailed and too descriptive compared with the papers that we typically publish as Analysis, with no argument being put forward. -Thank you. We have shortened the manuscript from almost 4000 words to 2471. Furthermore, as also suggested by Reviewer 1, we have removed a lot of the descriptive/background material and added more data and emphasis relating to current challenges in NHS genomics and how the 100,000 Genomes Project is addressing these. 2) Editors also found the paper unclear as to when one of the key objectives of the 100,000 Genomes Project -- "to bring benefit to NHS patients" -- is supposed to be met and whether any of this goal has been met thus far. We would usually expect Analysis articles that cover specific projects and initiatives to include some information about outcomes, barriers, challenges etc. -Thank you. We have added examples of how a result can change management of a family and additional metrics around reports returned and diagnostic rate. We have also added a full section to the end entitled “Challenges, hurdles and future directions” as well as box e “100,000 Genomes Project: examples of early steps in catalysing complex change”, in which additional complex hurdles are addressed.
    [Show full text]
  • Genomics England Is a Department of Health Company • Seconded to Genomics England from Queen Mary/Barts Who Pay My Salary • Multiple Industry Partnerships E.G
    The 100,000 Genomes Project Transforming Healthcare Berlin Institute of Health Prof Sir Mark Caulfield FMedSci Chief Scientist William Harvey Research Institute Queen Mary University of London Disclosures • Genomics England is a Department of Health Company • Seconded to Genomics England from Queen Mary/Barts who pay my salary • Multiple industry partnerships e.g. Illumina, iQVIA • No shares in anything except failed banks in 2008 29 January 2021 2 The 100,000 Genomes Project Milestones Announced by David Cameron, former Prime Minister in December 2012 –An Olympic Legacy Genomics England launched by then Secretary of State for Health in speech during NHS 65th Anniversary Celebrations, July 2013 Opening of new Sequencing Centre by Theresa May in 2016 CMO’s Generation Genome and the Life Sciences report in 2017 Commissioning of new NHS Genomic Medicine Service October 2018 Reached goal of sequencing 100,000 genomes in December 2018 “aspiration to undertake 5 million genome analyses over the next 5 years” The 100,000 Genomes Project in numbers 29 January 2021 How did the 100,000 Genomes Project work • 13 NHS Genomic Medicine Centres covering England, over 98 hospitals • Responsible for identifying and recruiting participants and for clinical care following results • Northern Ireland, Scotland and Wales joined Discovery Forum Industry Users 29 January 2021 5 Scalable disease diagnostics Sequence depth germline 36x to 40x Somatic 82x to 100x Patient/ family Validation Outcomes Phenotypes Clinical DNA GeCIP(s) & Pedigree assessment Gene Report
    [Show full text]
  • Endocrine and Metabolism Detailed Research Plan
    Genomics England Clinical Interpretation Partnership (GeCIP) Detailed Research Plan Form Application Summary GeCIP domain name Metabolic and Endocrine Disease Project title Whole genome sequencing to improve diagnosis and management of (max 150 characters) inherited metabolic and endocrine disorders Objectives. Set out the key objectives of your research. (max 200 words) Our major objectives are to use data from high-throughput whole genome sequencing to advance the understanding of the aetiology and heterogeneity of a range of important inherited metabolic and endocrine syndromes where full understanding is currently lacking. We will gain insights into disease mechanism and to novel therapeutic opportunities. Specific aims: 1. We will develop and implement bioinformatics algorithms and pipelines to categorise rare, severe inherited metabolic and endocrine disorders into homogeneous phenotypic groups. This will improve gene identification, assist genotype-phenotype correlations and future stratification prior to intervention studies. 2. We will identify novel causative genes and establish clinically useful risk scores to facilitate identification of novel disease genes, genetic risks and modifying factors to enable NHS diagnostic testing, prediction of disease onset, penetrance and clinical severity. 3. We will use our extensive experience in phenotyping in cellular and animal model systems to study disease mechanism. 4. We will recall and invite affected individuals for further deep metabolic and endocrine phenotyping to better understand how their diseases impact on their in vivo physiology. 5. We will use our extensive nexus of collaborative relations with the biotech and pharm industry to work together to develop novel approaches to therapy of these disorders. 6. We will work together with other GeCIPs and GMCs to train the next generation of scientists, technologists and clinicians in genomic medicine.
    [Show full text]
  • The Ethical and Legal Framework for a Genomics England and Sano Genetics Participant Engagement Platform
    The ethical and legal framework for a Genomics England and Sano Genetics participant engagement platform england Authors Colin Mitchell, Tanya Brigden and Alison Hall April 2021 A PHG Foundation report on the ethical and legal framework for a Genomics England and Sano Genetics participant engagement platform developed with funding from Innovate UK’s Digital Health Technology Catalyst competition. Acknowledgements This report is funded through grant funding from Innovate UK Industry Strategy Challenge Fund, Digital Health Technology Catalyst Round 4: Collaborative R&D, grant number 105415. We thank Fiona Maleady-Crowe, Shahla Salehi and Christine Patch (from Genomics England), Patrick Short (Sano Genetics) and other members of the project team for their input. Declaration of interests Alison Hall is a member of the Ethics Advisory Committee of Genomics England. Disclaimer The following report is intended to provide general information and understanding of the law. It should not be considered legal advice, nor used as a substitute for seeking qualified legal advice. URLs in this report were correct as of March 2021 Written and produced by PHG Foundation 2 Worts Causeway, Cambridge, CB1 8RN, UK +44 (0)1223 761900 www.phgfoundation.org © 2021 PHG Foundation Correspondence to: [email protected] The PHG Foundation is a health policy think-tank and linked exempt charity of the University of Cambridge. We work to achieve better health through the responsible and evidence- based application of biomedical science. We are a registered company, no. 5823194. PHG Foundation 2021 The ethical and legal framework for a participant engagement platform Executive summary The development of digital technologies has greatly increased the potential for more active involvement by participants in large-scale, long-term health research.
    [Show full text]
  • Genome Research Limited Strategic Overview Contents
    QUINQUENNIAL REVIEW 2021-2026 Genome Research Limited Strategic Overview Contents Executive Summary 1 Genome Research Limited (GRL): Mission and Vision Mission | Vision | Background to Genomes and BioData 2 Background to Wellcome, GRL and the Wellcome Genome Campus The Wellcome Genome Campus in 2020 3 Partnership with EMBL-European Bioinformatics Institute People and Culture 4 Delivery of the GRL’s Mission 5 Evaluation of Impact | Leadership, Governance and Management 6 Risks and Challenges 7 Funding Request and Assumptions 8 The next 25 years of the Wellcome Genome Campus Strategic Priorities for the next 25 years 9 An Evolving Community of Organisations with Shared Guiding Principles, Values and Kinships 10 The Wellcome Sanger Institute Background | Mission | Strategic Profile of the Sanger Institute 11 The Sanger Institute’s Research Culture Goals, Principles and Structure of Sanger Institute Research 12 Platforms for Data Generation and Data Handling Incubating the Next Generation of Genome Scientists 14 Engagement with the National and International Research Community Achievements | Between 2014 and 2019 15 Deliverables 16 Financial Allocations 17 Entrepreneurship and Innovation Background to Entrepreneurship and Innovation in Genomes and Biodata Background to Innovation on the Wellcome Genome Campus 18 Mission | Expansion of the Wellcome Genome Campus and Innovation 19 Connecting Science Background | Mission and Approach 21 Engagement | Learning and Training | Expansion of the Wellcome Genome Campus and the “Genome Gateway” 22 QUINQUENNIAL REVIEW 2021-2026 GRL STRATEGIC OVERVIEW Executive Summary Extraordinary opportunities and challenges are posed to 21st century biomedical science by the information encoded in genome sequences. Through the impact of its collective activities Genome Research Ltd (GRL) will provide global leadership in shaping and accelerating the revolution in biology, and its ramifying applications, engendered by the ever escalating wave of data from genomes.
    [Show full text]
  • This Exhibition Introduces the Role That the Wellcome Genome Campus
    Welcome to our exhibition about the future plans for the Wellcome Genome Campus. This exhibition introduces the role that the Wellcome Genome Campus has played in developing the science of genomics and biodata and how we want to ensure the Campus stays at the forefront of this area of scientific research. We have been working with a wide ranging technical team to start to develop our ideas about how the Campus could grow and deliver benefits for both our scientific community and the surrounding area over the next 25 years. This is the start of process of consultation with the local Parishes to help shape our proposals. We look forward to talking to you about our ideas in more detail. THE WELLCOME TRUST “Good health makes life better. We want to improve health for everyone by helping great ideas to thrive.” Wellcome exists to improve health for everyone by helping great ideas to thrive. Wellcome is a global charitable foundation, both politically and financially independent. It supports scientists and researchers to take on big problems, fuel imaginations, and spark debate. Wellcome supports over 14,000 people in more than 70 countries. In the next five years, Wellcome aims to help thousands of curious, passionate people all over the world explore ideas in science, population health, medical innovation, the humanities and social sciences and public engagement. Wellcome’s vision is divided into three ‘impact areas’: • Maximising the potential of research to improve human health • Delivering innovations that prevent or treat health problems • Engaging society to shape choices that lead to better health Wellcome has been the de facto owner of the Wellcome Genome Campus estate since the establishment of what was then called the Sanger Centre, in 1992.
    [Show full text]
  • Department of Health & Social Care
    ,s From the Rt Hon Jeremy Hunt MP Secretary of State for Health and Social Care Department 39 Victoria Street of Health & London Social Care SWl H OEU 020 7210 4850 POC 1134483 The Rt Hon Norman Lamb MP Chair, Science and Technology Committee ,. i ' House of Commons London - 6 JUN 2018 SWIA OAA ]- A, ',--, Many thanks for your considered letter on behalf of the Science and Technology Committee and your helpful comments relating to the National Qenomic Medicine Service. Building on the world leading 100,000 Genomes Project, the UK will enhance its intemational leadership as one of the first countries in the world to establish a fully integrated Genomic Medicine Service (GMS) from October 201 8. Through the GMS, NHS England will provide comprehensive and equitable access to the latest in genomic testing, including Whole Genome Sequencing (WGS), across the whole country. To deliver the vision that the Chief Medical Officer for England set out in her annual report 'Generation Genome', the new GMS will be supported by a network of National Genomic Laboratory Hubs (GLHs) that will deliver an integrated system for genomic testing, working to clear common standards and protocols, supported by, for the first time, a comprehensive national directory of genomic tests for specified cancers and rare diseases that encompasses the entire testing repertoire from WGS to tests for single genes, molecular markers and other functional genomic tests. The national directory of genomic tests will define situations in which whole genome sequencing has sufficient evidence to be used as a first-line test, alongside situations in which an altemative test should be used, either instead of or before, a whole genome sequence is appropriate foruse.
    [Show full text]