Curious Kid, Unconventional Scientist Acclaimed Scientist to Lead the New Department of Biochemistry and Molecular Genetics and Halt Cancer

Winter 2014-15 Volume 02, Number 01

A publication for the alumni and friends of Northwestern University Feinberg School of Medicine

P.20 Curious Kid, Unconventional Scientist Acclaimed scientist to lead the new Department of Biochemistry and Molecular Genetics and halt cancer.

P.14 P.24

Zeroing In On 2O14 Quality Care Activities & Accomplishments By Design ADDRESS ALL CORRESPONDENCE TO: Northwestern University Call or e-mail us at 312.503.4210 or Feinberg School of Medicine [email protected] Office of Communications ©2015 Northwestern University. 420 E. Superior Street Northwestern Medicine® is a federally Rubloff 12th floor registered trademark of Northwestern Chicago, IL 60611 Memorial HealthCare and is used by Northwestern University.

SPOOFING THE FILM FREAKY FRIDAY, STUDENTS SATIRIZED THE GENERATION GAP BETWEEN MEDICAL STUDENTS AND ESTABLISHED DOCTORS AT THE 36TH ANNUAL STUDENT SKETCH COMEDY SHOW IN VIVO, HELD NOVEMBER 14. READ ABOUT THE SHOW ONLINE AT MAGAZINE.NM.ORG. Northwestern Medicine 02 Northwestern Medicine Leadership Message WINTER 2014-15 Magazine Many achievements in 2014

VOLUME 02, NUMBER 01 Campus News MAGAZINE.NM.ORG 03 Three Gifts Will Help Fund New Biomedical Research Building 04 3-D Printed Models for Pediatric Surgical Training 06 Faculty Awards and Honors Northwestern Medicine Magazine is 08 Leon Platanias Named to Head Robert H. Lurie Comprehensive published quarterly for alumni and friends Cancer Center of Northwestern University of Northwestern University Feinberg 09 Tackling Gender and Sex Issues in Medical Education School of Medicine, Northwestern 10 Research Briefs Memorial HealthCare, and the McGaw 12 Media Highlights Medical Center of Northwestern University. 14 Features Material in Northwestern Medicine Magazine may not be reproduced without prior consent and Ward Rounds (Alumni) News proper credit. 28 Alumni President’s Message 29 Progress Notes – Recognizing Our Military Veterans, Part 2 36 Carol Rosenberg, ’80 MD, Caring for Cancer Survivors 38 Alumni Profiles in Cultural Diversity: Ulysses Grant Dailey, 1906 MD, and Carlos Montezuma, 1889 MD 39 Remembering Alumnus Harold Frost, ’46 MD

INTERIM EXECUTIVE Alice Perry, ‘88 PT 40 In Memoriam and Upcoming Events DIREC TOR OF Robert M. Rosa, MD, COMMUNICATIONS Vice Dean for Reg- Nicole Mladic ulatory Affairs and COMMUNICATIONS Chief Compliance CURIOUS KID, DIRECTOR/EDITOR Officer Michele M. Weber, MSC ML Farrell, Senior UNCONVENTIONAL Associate Director, EDITORIAL ASSISTANT Anita Chase Alumni Relations SCIENTIST Michele M. Weber, MSC, CONTRIBUTING WRITERS Magazine Editor Ali Shilatifard is chair of the new Andrea Arntsen-Harris ALUMNI ASSOCIATION Department of Biochemistry and Anita Chase David Winchester, ‘63 Molecular Genetics Nora Dunne MD, President Martha O’Connell Bruce Scharschmidt, ’70 Kevin W. McCullough MD, President-elect Marla Paul Sarah Plumridge INSIDE FRONT COVER PHOTOGRAPHY Cheryl SooHoo Randy Belice EDITORIAL BOARD F. Douglas Carr, ’78 MD ADDITIONAL PHOTOGRAPHY Carla Hightower, ’87 MD, Anita Chase: p. 7 ’91GME Nathan Mandell: p. 15 Jennifer Hobbs, ’07 PhD P.20 Northwestern Memorial Kerry Humes, ’90 MD HealthCare: p. 2 James Kelly, ’83 MD Bruce Powell: p. 18 Alice Perry, ’88 PT Thomas Pitts, ’76 MD DESIGN ZEROING IN ON QUALITY CARE Paloma Toledo, ’03 MD/ Firebelly Design MPH 2014 ACTIVITIES & BY DESIGN Eric G. Neilson, MD, Dean ACCOMPLISHMENTS New Outpatient Facility Meets Alan Krensky, MD, Vice Growing Healthcare Trend Dean for Develop- ment and Alumni Relations

P.14 P.24

fb.me/feinbergschoolofmedicine MAGAZINE.NM.ORG: Additional Content Online Image Slideshow Video twitter.com/nufeinbergmed flickr.com/feinbergschoolofmedicine

WINTER 2014-15 1 Northwestern Medicine Leadership

$927 MILLION

$0 $1.75 B

NORTHWESTERN MEDICINE CAMPAIGN PROGRESS

Happy New Year! Looking back, we were more than 65 locations across Chicago and fortunate to have enjoyed many achieve- its suburbs. We have taken a thoughtful ments this past year, though celebrating approach to managing our growth. Whether the 5th anniversary of the Northwestern we are evaluating a potential affiliation Medicine strategic plan is a milestone that with other health systems or developing was particularly remarkable. Together with new ambulatory care sites, our primary the Feinberg School of Medicine, we have objective is to ensure they will strengthen made significant progress toward achieving our ability to provide our patients with the goals of our plan: to deliver excep- safer, more effective care wherever they tional care; advance medical science and access Northwestern Medicine. knowledge; and develop people, culture One of our newest facilities, the and resources. Our success to date is outpatient care building that recently directly attributable to the collective opened on the Chicago campus and is commitment of the boards of trustees and highlighted on page 24, exemplifies our senior physician and executive leadership growth strategy. As you will read, it is of Northwestern University, the Feinberg designed to support the latest medical School of Medicine and Northwestern technologies as well as to bring together Memorial HealthCare. complementary specialists to foster better In previous editions of Northwestern collaboration to support better care Medicine Magazine, Dr. Neilson has outcomes for our patients. described the significant growth in our As a result of our disciplined planning research activities, which will soon achieve and ongoing collaboration with our another important milestone when we partners across the Evanston and Chicago break ground for the new biomedical campuses of Northwestern, we are well research building on the site of the former positioned to advance our shared discov- Prentice Women’s Hospital. This state-of- ery, education and clinical missions during the-art facility will add 600,000 more this period of significant change in the square feet of lab space, allowing us to healthcare marketplace. attract an additional $150 million in We look forward to 2015 with great research funding. Research expansion confidence for the many shared successes will support the Feinberg School of yet to come. Medicine’s cardiovascular, cancer, and neurodegenerative diseases departments’ Best, ability to maintain their reputation as national leaders in their respective fields and support our ability to expand into emerging areas of biomedical research. Similarly, our health system has grown to Dean M. Harrison provide greater access for our patients closer President and CEO to where they live and work. Today more Northwestern Memorial HealthCare than 25,000 physicians, nurses, staff and volunteers come together to deliver care at

2 NORTHWESTERN MEDICINE MAGAZINE Campus News

Three Trustee Gifts to help Fund New Biomedical Research Building

WRITTEN BY: Andrea Arntsen-Harris

Northwestern University Feinberg School President’s Fund, the Bienen School of of Medicine recently received gifts totaling Music, and a Feinberg professorship within $6 million from three Northwestern the Department of Obstetrics and Gynecol- University Trustees in support of the new ogy. Dr. Senyei is a Trustee and member of Biomedical Research Building. Dr. Andrew E. the newly formed Northwestern Medicine and Mrs. JoAnn Senyei have committed $3 Campaign Cabinet. million, the Weinberg family has provided “Attracting world-class medical re- $2 million, and Howard J. Trienens has searchers requires world-class facilities. pledged $1 million in generous, unre- The new research building will significantly stricted support. improve our ability to attract and also retain A top fundraising priority for We Will. the next generation of research leaders. It The Campaign for Northwestern Medicine, will also allow us to be more competitive this 12-story facility will create additional for National Institutes of Health funding, space to conduct lifesaving biomedical which is an important part of growing and Building will attract extraordinary physi- research. Located in downtown Chicago, maintaining our excellence in a highly cian–scientists who can both make a the new building will help to attract the competitive world,” says Dr. Senyei. difference today and develop the treat- world’s best medical researchers focused “Northwestern’s amazing rise in ments, procedures and protocols that will on finding tomorrow’s cures. The facility research stature from when I was a medical improve the lives of future generations.” will double the research enterprise and student to today is incredibly impressive provide crucial space for investigators and inspiring,” he continues. “Witnessing HOWARD TRIENENS working in the areas of cancer, heart the passion and performance of both the Howard Trienens is a University Trustee disease, neurodegenerative disorders, faculty and the students has inspired us to and an alumnus of the undergraduate diabetes and others. help continue the trajectory of excellence business program (’45 BBA) and the Law The new 600,000-square-foot build- for the next generation.” School (’49 JD). His generosity has ex- ing—to expand to 1.2 million square feet tended across Northwestern—including and 25 stories upon completion—will DAVID WEINBERG athletics, the college and law school annual connect floor-by-floor with the Robert H. The Weinberg family has a distinguished funds, and the library. In 1999, in memory Lurie Medical Research Center. Construc- history of philanthropy at Northwestern of his late wife Paula, Mr. Trienens created tion will be phased, with the building University. David Weinberg serves in the Howard & Paula Trienens Fund to ultimately standing as the world’s tallest several volunteer roles in addition to support the continued growth and develop- medical research facility. Northwestern providing sustaining gifts to support ment of the Robert H. Lurie Comprehensive expects to attract $150 million a year in biomedical research. He is vice chair of Cancer Center of Northwestern University. new research funding, create 2,000 the University’s Board of Trustees and “This new building represents the full-time jobs, and generate an additional former chair of its Northwestern Medi- future for several of my interests: research $3.9 billion in economic activity in Chicago cine Committee. He also serves as vice at Northwestern, growth of the Chicago over the next 10 years. chair of the Northwestern Medicine economy and improvements in medical Campaign Cabinet. practice,” says Trienens. ANDREW AND JOANN SENYEI “One of the great features of academic The philanthropic leadership of these Andrew Senyei, ’79 MD, and his wife JoAnn, medical centers like Northwestern is three medical school supporters forecasts have been steadfast supporters of translational research—taking discoveries great things for the future as we prepare to Northwestern University for more than 10 from the lab to the patient’s bedside,” he break ground for this state-of-the-art years. The couple has supported the explains. “The Biomedical Research research facility in spring 2015.

WINTER 2014-15 3 CAMPUS NEWS

3-D Printed Models Provide Lifelike Simulations for Training Pediatric Surgeons

WRITTEN BY: Nora Dunne PHOTOGRAPHY BY: Nora Dunne and Lauren Davis

Using 3-D printing technology, Katherine Barsness, MD, ’11 MS, For beginning surgeons, the Innovations Lab prints plaster associate professor in surgery and medical education, may have molds to make silicone organs that are placed in the ribcage. More solved a common catch-22 for pediatric surgeons: To deftly advanced surgeons work with fetal bovine tissue which would perform tricky surgical procedures in a newborn chest cavity no normally be thrown out by commercial slaughterhouses. The bigger than an egg, they need practice with the real thing. bovine tissue is surgically configured to mimic neonatal congenital “The overwhelming majority of surgeons just train in the defects such as tracheoesophageal fistula, an abnormal connection operating room,” says Dr. Barsness. “Everybody has a learning between the windpipe and the stomach. These conditions are so curve when they’re developing new skills, a time when they make rare that surgeons may encounter them only a few times a year mistakes while trying to master a certain technique. Unfortunately, and, potentially, fall out of practice. a learning curve places patients at risk.” To prevent consequential errors from occurring on real patients, Dr. Barsness has created life-sized, reusable models of a newborn’s ribcage in collaboration with engineers from Feinberg’s Innovations Lab and the McCormick School of Engineering and Applied Sciences. With the models, training pediatric surgeons receive uniquely authentic simulation-based education. McCormick’s Segal Design Institute produces the models with 3-D printers, which turn digital files into three-dimensional solid objects one very thin layer of material at a time. The resulting plastic ribcages become anatomically correct replicas of an infant’s chest cavity when covered with a synthetic silicone skin and filled with tissue. Through the Northwestern Simulation training facility, students use the models to practice performing complicated minimally invasive procedures to repair rare birth defects. “It’s invaluable to practice on something that looks this realistic. It’s an experience that will only benefit my patients in the future,” says Matthew Landman, a pediatric surgery fellow at Children’s Hospital Colorado. He was one of 38 visiting second-year fellows from the United States and Canada to attend a gold-standard pediatric surgical training hosted by Dr. Barsness in September through the Accredi- tation Council for Graduate Medical Education. Landman and other fellows, who had never worked with 3-D TRAINEES USE 3-D MODELS TO PRACTICE PERFORMING COMPLICATED printed models before, said they participated in the course to learn MINIMALLY INVASIVE PROCEDURES TO REPAIR RARE BIRTH DEFECTS. techniques through lifelike simulations that they don’t have at their own institutions. Barsness also leads training courses throughout the year for practicing surgeons.

4 MAGAZINE.NM.ORG Created using 3-D printing, this plastic ribcage becomes an anatomically correct replica of an infant’s chest cavity when covered with a synthetic silicone skin and filled with tissue.

Katherine Barsness (right), MD, ’11 MS, associate professor in surgery and medical education, leads a pediatric surgical training course using the models for visiting second-year fellows.

Dr. Barsness believes that models like Funding is another issue. Though through papers in the Journal of Pediatric hers will eventually become the norm for materials for printing the ribcage cost only Surgery and the Journal of Laparoendo- surgical training, instead of having trainees about $200, the printers themselves are a scopic & Advanced Surgical Techniques, practice in the operating room or work on significant investment, as are the among others. live animals. However, she points out resources to support them. But she says several challenges that prevent that future acceptance of the models—proving their The work is funded by Jeffrey C. Maling from becoming an immediate reality. value—is the biggest struggle right now. and Rebecca L. Johnston, and the Children’s “First is dedicated time for education “That acceptance is predicated on data. Research Fund Junior Board of the Stanley outside the operating room. We need So our next step is to show that using the Manne Children’s Research Institute. programs to let their trainees leave clinical simulation models really does improve duties for dedicated simulation-based physicians’ performances in the operating education,” she says. “Second, there are very room,” says Dr. Barsness. few pediatric surgeons in the world who are Her lab has already published the trained to conduct this type of education.” promising results of initial studies,

WINTER 2014-15 5 CAMPUS NEWS

Faculty Awards and Honors

Jeremiah Stamler, MD, founding chair and Shira N. Dinner, MD, At the event, Richard professor emeritus of the Department of assistant professor Miller, PhD, professor Preventive Medicine-Epidemiology, was in medicine-hematol- in pharmacology, named the 2014 recipient of the American ogy/oncology, was received the Faculty Heart Association’s Eugene Braunwald selected to partici- Teaching Award and Academic Mentorship Award. The award pate in the American Greg Smith, PhD, recognizes an individual whose academic Society of Hematol- associate professor career includes a long-term record of ogy Clinical Research in microbiology- GREG SMITH, PHD successful mentoring of promising young Training Institute (CRTI) program. This immunology, received academicians. Dr. Stamler devoted his education and mentorship program is the Faculty Service Award. professional career to researching the cause designed to prepare current hematology and prevention of cardiovascular disease. and hematology/oncology fellows and Mark C. Hersam, PhD, He has received numerous awards and junior faculty for careers in patient-ori- the Bette and Neison honors from the AHA, including the ented clinical research. Harris Chair in establishment of the Jeremiah Stamler, MD, Teaching Excellence Dane Chetkovich, MD, PhD, associate and professor of professor in the Ken and Ruth Davee materials science Department of Neurology and physiology, and engineering at and Brian Mustanski, PhD, associate the McCormick professor in medical social sciences and School of Engineering and Applied Science, psychiatry and behavioral sciences, have professor of chemistry in the Weinberg accepted invitations to join two National College of Arts and Sciences, professor of Institutes for Health’s Center for Scientific medicine-pulmonary at the Feinberg School Review study sections. Members are of Medicine, and director of Northwestern’s selected based on demonstrated compe- Materials Research Center, has been named tence and achievement in their scientific a 2014 MacArthur Fellow. disciplines. Part of their responsibility is to Hersam is developing novel nanomateri- survey the status of research in their fields. als for use in information technology, Mustanski has biotechnology, energy (solar cells and joined the Behavioral batteries), and flexible electronics for and Social Conse- personalized health monitoring. Hersam and quences of HIV/AIDS his research lab have been working primarily Study Section with carbon nanotubes and graphene, but through June 2020, the support of the MacArthur award will and Dr. Chetkovich allow the lab to diversify its materials set JEREMIAH STAMLER, MD (right) joins the Clinical Neuroplasticity and to other elements in the periodic table. Neurotransmitters Study Section for a term His numerous awards have included the New Investigator Award. Other significant through June 2018. Beckman Young Investigator Award, the honors include the Donald Reid Medal from National Science Foundation CAREER the Joint Committee of the London School Students, faculty Award, a Sloan Research Fellowship, the of Hygiene and Tropical Medicine and the members and alumni Presidential Early Career Award for Royal College of Physicians; the National gathered to cel- Scientists and Engineers (PECASE) and six Cholesterol Award at the First National ebrate the Walter S. Teacher of the Year Awards. Cholesterol Conference; the James D. Bruce and Lucienne Driskill Memorial Award for Distinguished Contribu- Graduate Training The Patient-Centered Outcomes Research tions in Preventive Medicine from the Program in Life Institute (PCORI) and the Agency for American College of Physicians; and Sciences at the Third Healthcare Research and Quality election to the Center for Science in the Annual Driskill Day, (AHRQ) announced that AHRQ has selected Public Interest’s Nutrition Hall of Fame. held in September. RICHARD MILLER, PHD the research team that will conduct a

6 NORTHWESTERN MEDICINE MAGAZINE Four New Administrators at Lurie Cancer Center five-year, $20-million project funded by PCORI to evaluate the Under the leadership of Leon Platanias, MD, PhD, effectiveness of different treatment strategies for women with recently named director (see page 8), four new adminis- uterine fibroids. trators have been appointed at the Robert H. Lurie Erica E. Marsh, MD, assistant professor in obstetrics and Comprehensive Cancer Center of Northwestern University: gynecology-reproductive endocrinology and infertility, with Francis J. Giles, MB, MD, FRCPI, Northwestern Fertility and Reproductive Medicine, serves FRCPath, professor in medicine- as the principal investigator for Northwestern’s portion of hematology/oncology, has been the research project. appointed deputy director, oversee- ing Northwestern Medicine’s clinical Health & Medicine Policy Research Group, a Chicago-based research cancer programs and non-profit founded in 1981 by Quentin Young, ’48 MD, working developmental therapeutics to improve the health of all Illinoisans by promoting health equity, initiatives. Dr. Giles is a global leader has announced the recipients of the 2014 HMPRG Awards repre- in the field of developmental therapeutics, with a special senting leaders in the fields of medicine, policy, public health and emphasis on personalized therapies for cancer patients; advocacy whose work promotes social justice and challenges Milan Mrksich, PhD, professor in inequities in health care. Northwestern University Feinberg School cell and molecular biology, has of Medicine professor James W. Collins, Jr., been appointed associate director MD, MPH, received the Research Award. for research technology and Dr. Collins, professor of pediatrics-neona- infrastructure and will be respon- tology and medical director of the Neonatal sible for oversight of the Lurie Intensive Care Unit at Ann & Robert H. Lurie Cancer Center’s 15 shared Children’s Hospital of Chicago, is the resource facilities. Dr. Mrksich’s co-recipient of the HMPRG Research Award research combines synthetic chemistry with materials with his research partner Richard David, MD, science to study important problems in cell biology; of John H. Stroger, Jr. Hospital of Cook County. Drs. Collins and David Mark Agulnik, MD, associate are leaders in explicating the role of racism and social inequity in professor in medicine-hematol- creating gaps in neonatal health and have played a major role in ogy/oncology and director of the promoting the current focus on the social determinants of health Hematology/Oncology Fellowship as a cause of adverse pregnancy outcomes. Program, has been appointed director of the Clinical Research Alisha Thomas, ’05 MD, instructor of clinical Office (CRO). Dr. Agulnik is a family and community medicine, received leader in the field of medical the 2014 Illinois Family Medicine Teacher oncology, with a focus on sarcomas, head and neck of the Year Award from the Illinois Academy cancers, and endocrine cancers; of Family Physicians (IAFP). Dr. Thomas was Kathleen Green, PhD, Joseph L. nominated for this award by her students Mayberry, Sr., Professor of in the Education-Centered Medical Home Pathology and Toxicology, (ECMH) program. When the new curriculum professor of dermatology, director launched, she was one of the first three pilot ECMH mentors. for Northwestern’s PhD training The Teacher of the Year Award recognizes a physician who Cluster in Cancer Biology and the has made outstanding contributions to the field of teaching National Cancer Institute-funded family medicine by developing and implementing innovations Carcinogenesis Training Program, in family medicine education and who inspires new family secretary of the American Society for Cell Biology and physicians through dedication, mentoring and support. deputy editor-in-chief of the Journal of Cell Science, has been named associate research director for basic sciences research. Dr. Green’s research is focused on understanding the molecular basis of how cells stick together and how to regulate chemical signals important for development and differentiation.

WINTER 2014-15 7 CAMPUS NEWS

Leon Platanias Appointed Director of Lurie Cancer Center

WRITTEN BY: Nora Dunne PHOTOGRAPHY BY: Northwestern Memorial HealthCare

Leonidas Platanias, MD, PhD, has been appointed director of the Robert H. Lurie Comprehensive Cancer Center of North- western University, a position he has served in interim since January 2014. Dr. Platanias joined Northwestern University Feinberg School of Medicine in 2002 as the Lurie Cancer Center’s first deputy director and the Jesse, Sara, Andrew, Abigail, Benjamin and Elizabeth Lurie Professor of Oncology in Medicine- Hematology/Oncology. AS DIRECTOR, LEONIDAS PLATANIAS, MD, PHD, WILL CONTINUE TO LEAD THE ROBERT H. LURIE “Leon has already contributed greatly to COMPREHENSIVE CANCER CENTER OF NORTHWESTERN UNIVERSITY. the Lurie Cancer Center, through both his leadership and his scientific achievements,” says Eric G. Neilson, MD, vice president for Before arriving at Feinberg, Dr. Platanias and Cytokine Research in 2013. A member Medical Affairs and Lewis Landsberg Dean. was chief of the Division of Hematology/ of various scientific societies, Dr. Platanias “As permanent director, he will continue in Oncology at the University of Illinois at served as president of the International that vein, driving the center’s expansion Chicago. He earned his medical degree from Society for Interferon and Cytokine and maintaining its reputation as a the University of Patras Medical School in Research in 2010-2011. He currently premiere venue for research, clinical Greece before taking on a research fellow- serves on the board of directors of the care and collaboration.” ship at the National Heart, Lung, and Blood International Cytokine Society. Platanias will oversee both the clinical Institute at the National Institutes of He is an associate editor of Leukemia operations in the Lurie Cancer Center and Health (NIH). He completed a residency in and Lymphoma and the Journal of Interferon growing basic science research programs, internal medicine at the State University of and Cytokine Research and he sits on the including those to translate basic and New York, Downstate Medical Center, and a editorial board of the Journal of Biological clinical research into personalized medicine. fellowship in hematology-oncology at the Chemistry. He has been a chair or member “I am very excited about the future of University of Chicago Hospitals. of many review committees at the NIH, the the Lurie Cancer Center and of Northwestern Dr. Platanias’s molecular biology and Department of Defense, the Department Medicine,” says Dr. Platanias. “We are biochemistry research, spanning more than of Veterans Affairs and the Leukemia and developing programs that bridge basic 20 years and highlighted in more than 250 Lymphoma Society of America. science and clinical care and will establish published papers, focuses on signaling “I am very pleased that Leon was Chicago as a global leader in the delivery pathways in cancer cells and developing selected to carry forward the strong of personalized cancer treatment. We are therapies that target those pathways to traditions of the Robert H. Lurie Compre- extremely fortunate to have the enduring treat malignancies. He is well known for his hensive Cancer Center as its new director,” support of remarkable philanthropic partners work involving cytokines, which are specific says Ann Lurie, president of Lurie Holdings, in all our endeavors, and I am particularly proteins within the blood that have the Inc. “I am sure he is the right leader for grateful to Ann Lurie whose continuous ability to fight cancer. these exciting times. He will be an excep- passionate commitment to the Lurie Cancer Among his many career honors, Dr. tional advocate for the serious work ahead Center has a profound impact on cancer Platanias received the Seymour & Vivian to find more enduring cures for cancer.” research and the clinical care of our patients.” Milstein Award for Excellence in Interferon

8 MAGAZINE.NM.ORG Tackling Gender and Sex Issues in Medical Education

WRITTEN BY: Sarah Plumridge

Two Feinberg School of Medicine faculty committee and the head child and adolescent psychiatrist for helped create the Association of American the Gender and Sex Development Program at Ann & Robert H. Medical Colleges’ (AAMC) first guidelines Lurie Children’s Hospital of Chicago. for medical schools on improving health As a specialist in patients with gender-related issues, Dr. care for people who are lesbian, gay, Leibowitz is aware that many of these individuals have diffi- bisexual, transgender (LGBT), gender culty trusting that doctors will understand their identity and nonconforming or born with differences specific healthcare needs. He hopes that by educating other of sex development (DSD). physicians about these issues, that both patients and doctors AS DIRECTOR, LEONIDAS PLATANIAS, MD, PHD, WILL CONTINUE TO LEAD THE ROBERT H. LURIE “This resource guide is important will feel more comfortable. COMPREHENSIVE CANCER CENTER OF NORTHWESTERN UNIVERSITY. because these populations have been histori- “To expect that physicians will learn these issues overnight cally disproportionately harmed or neglected is a challenging task,” he says. “But if a patient can’t trust a in the medical system,” says Alice Dreger, physician, who else can they turn to for the proper care?” PhD, professor of clinical medical humanities and bioethics and a member of the AAMC FEINBERG’S GENDER AND SEX EDUCATION Advisory Committee on Sexual Orientation, Even before the report came out, Feinberg has been working on Gender Identity, and Sex Development. “By implementing programs that address these recommendations. being a part of this committee, I hope I am In 2011, Dreger led a team examining how Feinberg could helping to seed a new generation of doctors increase and improve the teaching of LGBT patient care and who will know how to really help patients in human sexuality. The white paper, coauthored with Jerry Chen, these populations.” a fourth-year medical student, and Sarah B. Rodriguez, PhD, lec- “Implementing Curricular and Institu- turer in the Department of Medical Humanities and Bioethics, tional Climate Changes to Improve Health provided a model for how medical schools can start to improve Care for Individuals Who Are LGBT, Gender medical education around these issues. Nonconforming, or Born with DSD” provides Since then, Feinberg has established a Gender and Sexuality information about the role of academic Task Force, identifying important aspects related to the medical medicine and the healthcare system in school competencies and examining where they can be imple- supporting the unique needs of individuals mented in the curriculum. The goal is to encourage faculty to in these groups. move away from thinking of patients in these groups as The guide also highlights resources and separate from the general patient population. explains how to integrate this content into Dr. Leibowitz, who was a member of the task force, says, medical education, identifying 30 compe- “Transgender health brings together many doctors across tencies that physicians should master. disciplines: behavioral health, primary care, endocrinology and “The publication is designed to bring sometimes even surgery. I can’t think of another issue that medical education into the modern era by brings together such varied groups of physicians and illustrates raising important competencies students the need to collaborate and communicate on the behavioral, and trainees should be able to display medical, and surgical healthcare needs of an individual. By when providing care to patients,” explains incorporating these issues into the curriculum, we are moving Scott Leibowitz, MD, also on the advisory Feinberg ahead of most medical schools.”

WINTER 2014-15 9 CAMPUS NEWS

Research Briefs

Technologies at Feinberg, are co-lead authors of the study published Sept. 16 in Transla- tional Psychiatry. Redei previously developed a blood test that diagnosed depression in adolescents. Most of the markers Redei identified in the adult depression panel are different from those in adolescents. The new blood test will also allow physicians to use lab tests to determine what treatments will be most useful for each individual. “Currently, we know drug therapy is effective but not for everybody, and psychotherapy is effective but not for everybody,” Mohr says. “We know combined therapies are First Blood Test to Diagnose more effective than either alone, but maybe Depression in Adults by combining therapies we are using a scattershot approach. Having a blood test would allow us to better target treatment to individuals.” Another finding—the blood concentration The first blood test to diagnose major depression in adults has of three of the nine RNA markers remained been developed by Northwestern Medicine scientists, a break- different in depressed patients and non- through approach that provides an objective, scientific diagnosis. depressed controls, even if the depressed The test measures the levels of nine RNA blood markers. RNA patients achieved remission after the molecules are the messengers that interpret the DNA genetic code therapy. This appears to indicate a vulner- and carry out its instructions. ability to depression. The blood test also predicts who will benefit from cognitive “These three markers move us toward behavioral therapy based on the behavior of some of the markers. the ultimate goal of identifying predisposi- And the test showed the biological effects of cognitive behavioral tion to depression, even in the absence of therapy’s success. The levels of markers changed in patients who a current depressive episode,” says Redei, had the therapy for 18 weeks and were no longer depressed. the David Lawrence Stein Research Professor “This clearly indicates that you can have a blood-based of Psychiatric Diseases Affecting Children laboratory test for depression, providing a scientific diagnosis in and Adolescents. the same way someone is diagnosed with high blood pressure or “Being aware of people who are more high cholesterol,” says Eva Redei, PhD, professor of psychiatry and susceptible to recurring depression allows us behavioral sciences at the Feinberg School of Medicine, who to monitor them more closely,” Mohr notes. developed the test. “This test brings mental health diagnosis into “They can consider a maintenance dose of the 21st century and offers the first personalized medicine antidepressants or continued psychotherapy approach to people suffering from depression.” to diminish the severity of a future episode or The current method of diagnosing depression is subjective and prolong the intervals between episodes.” based on non-specific symptoms such as poor mood, fatigue and change in appetite, all of which can apply to a large number of The study was supported by grants R21 MH077234 and mental or physical problems. R01 MH059708 from the National Institute of Mental Redei and David Mohr, PhD, a professor of preventive medi- Health of the National Institutes of Health and by grants cine and director of the Center for Behavioral Intervention from the Davee Foundation.

10 NORTHWESTERN MEDICINE MAGAZINE Genetic Mutations Linked to Severe Epilepsy

Northwestern Medicine scientists discovered that genetic mutations in the KCNB1 potassium channel gene can result in severe early onset epilepsy. They found the mutations in three children with epileptic encephalopathy, a group of disorders that cause seizures and difficulties with cognitive and motor development. The same results applied to two other patients with similar “KCNB1 potassium channels are critical for neurons to generate dysfunction who had waited many years for a diagnosis. electrical signals and communicate with one another,” says Jennifer “Diagnostic uncertainty is very challenging for families,“ ex- Kearney, PhD, associate professor in pharmacology and a principal plains Kearney, “so finally having a cause for the disorder is very author of the study published in Annals of Neurology. “They valuable for alleviating stress and moving forward with knowledge normally dampen excitability of neurons. However, the mutations that may improve medical management.” caused channel dysfunction that in turn causes excessive excitability, resulting in seizures and disrupted development.” This research was supported by Scripps Genomic Medicine, NIH-NCATS Clinical and The team conducted whole exome sequencing (WES)—sequencing Translational Science Award UL1 RR025774, the Shaffer Family Foundation, the the human genes that encode proteins—on a child with epilepsy, as well Anne and Henry Zarrow Foundation and National Institutes of Health (NIH) grants as her unaffected sister and parents. They found a mutation in KCNB1. U01 HG006476, R01 NS053792, R01 NS032387 and F31 083097.

Calcium Channel Discovery Unlocks Brain Therapy Options

Calcium isn’t just for bones and teeth. It also has an important Scientists can use this information to understand how job in the brain, delivering signals to help neural stem cells mutations in this channel affect patients’ cognitive abilities. In function. But until now, scientists didn’t know how calcium got addition, suppressing CRAC channel activation might be a way to into these cells. control brain tumor formation. Murali Prakriya, PhD, associate professor in pharmacology, and his lab identified the channel that brings calcium into cells to control neurogenesis, a carefully choreographed brain process in which neural stem cells replicate and become neurons, structures that play vital roles in memory, learning and recovery following brain injury. “Knowing the mechanisms that control proliferation of neural stem cells can help us understand how we might apply stem-cell- based therapies for conditions like stroke and neurodegenerative diseases,” says Prakriya. “Now that we know how calcium enters neural stem cells, we can target and manipulate that pathway to 1mm 50µm regulate the functions of calcium signaling in these cells.” The scientists identified a pathway called the calcium AN IMAGE OF A MOUSE BRAIN SECTION (LEFT) SHOWS THE SUBVENTRICU- release-activated calcium (CRAC) channel, which they knew LAR ZONE, THE MAJOR NEUROGENIC REGION. THE YELLOW BOXED AREA existed elsewhere in the body. But the study, published in the MAGNIFIED (RIGHT) ILLUSTRATES SINGLE CELLS. THE RED ONES ARE IN THE Journal of Neuroscience, made two new important discoveries. PROLIFERATIVE PHASE. “First we found that CRAC channels constitute the major route of calcium entry in neural stem cells,” says Prakriya. “Second, we This study was supported by the National Institutes of Health grants NS057499 determined that the calcium that comes in through CRAC chan- and AI097302 and the Brain Research Foundation. nels regulates proliferation of neural stem cells.”

WINTER 2014-15 11 CAMPUS NEWS

attended an eight-week mindfulness-training program. Media Spotlight “We saw lower depression scores and improved ratings on sleep quality and quality of life for both groups,” says study author Ken Paller, PhD, professor of psychology and fellow of the Cognitive Neurology and Alzheimer’s Disease Center at 1 TABLETS COULD BE USED AS A SEDATIVE FOR Northwestern University. PRE-SURGERY KIDS YAHOO! TECH – AUGUST 6, 2014 3 MOST ASTHMATIC KIDS LACK HEALTH MANAGEMENT Playing with an iPad mini before going under anesthesia could PLANS AT SCHOOL relax some kids more than a sedative would, also making life FOX NEWS (NATIONAL) – SEPTEMBER 8, 2014 easier for their parents and hospital staff, according to a recent On the rare occasions when a child has died at school from study. “Anxiety is a major source of concern for children going an acute allergy attack or asthma attack, he or she usually to the hospital for anything, but especially for surgery, and it’s did not have a health management plan, or a so-called 504 also a major source of dissatisfaction for their parents,” says lead Plan, on file, says lead study author, Ruchi Gupta, MD, MPH, author Samuel C. Seiden, MD, assistant professor in anesthesi- associate professor of pediatrics–academic general pediatrics ology at the Feinberg School of Medicine. and primary care, and a member of the Center for Community Health at the Feinberg School of Medicine. 2 MINDFULNESS TRAINING HELPS ALZHEIMER’S PATIENTS AND CAREGIVERS 4 NU RESEARCHERS SHED LIGHT ON DOMESTIC THE NEW YORK TIMES – AUGUST 27, 2014 VIOLENCE AMONG SAME-SEX COUPLES A new study has shown that training in mindfulness—learning CHICAGO TRIBUNE – SEPTEMBER 19, 2014 how to focus on the present moment—may help improve the Same-sex couples may experience more domestic violence emotional well being of people with early-stage dementia due than opposite-sex couples, a Northwestern Medicine review of to Alzheimer’s, and their caregivers. Patients and caregivers research suggests. Richard Carroll, PhD, an associate professor

1 2

AUGUST

Feinberg Departments Rank High on NIH Funding List

WRITTEN BY: Nora Dunne

Seven departments at Northwestern University Feinberg School of Medicine rank in the top 10 in their discipline in a list of National Institutes of Health (NIH) funding to medical schools, with an additional four departments in the top 20, according to a recent report. The rankings, calculated by the Blue Ridge Institute for Medical Research,

12 MAGAZINE.NM.ORG in psychiatry and behavioral sciences at Northwestern’s Feinberg Siddique, MD, professor of cell and molecular biology in the Ken School of Medicine, and Feinberg PhD student, Colleen Stiles- and Ruth Davee Department of Neurology and the Department of Shields, found domestic violence rates among same-sex couples Cell and Molecular Biology at the Feinberg School of Medicine. were upward of twice as high as those of opposite-sex couples. 7 ECZEMA TIED TO BONE FRACTURE RISK IN STUDY 5 NATION NEEDS TO ADDRESS END-OF-LIFE CARE FOX NEWS (NATIONAL) – SEPTEMBER 25, 2014 CHICAGO SUN-TIMES – SEPTEMBER 22, 2014 Compared to people without eczema, those with the skin It’s time for a genuine debate about end-of-life care; one condition had more than double the risk of having had a frac- we hope will bring real change to a healthcare system that ture or bone or joint injury, according to the study. “Adults fails to respect the final wishes of far too many of us. “I see with eczema have higher rates of injuries, including fractures so much unnecessary prolonging of the dying process,” and bone and joint injuries,” says lead researcher Jonathan says Kathy Johnson Neely, MD, assistant professor in Silverberg, MD, PhD, MPH, an assistant professor of derma- medicine–hospital medicine, at Northwestern University tology, medical social sciences and preventive medicine at who serves on the palliative care team and is chair of Northwestern University. Northwestern Memorial Hospital’s medical ethics committee. 8 EBOLA FEARS ARE TRIGGERING MASS 6 SCIENTISTS CREATE FIRST MOUSE MODEL FOR ALS HYPOCHONDRIA DEMENTIA NEW YORK MAGAZINE – OCTOBER 7, 2014 FOX NEWS (NATIONAL) – SEPTEMBER 25, 2014 Ebola anxiety is so far proving to be a highly contagious Scientists have created the first animal model of amyotrophic thing. In a way, what we’re seeing here is hypochondria mani- lateral sclerosis (ALS) dementia in mice, which they say will allow fested on a mass scale, says Catherine F. Belling, PhD, an them to directly monitor test drugs to determine how they affect associate professor in medical education–medical humanities the brain. “This new model will allow rapid testing and direct and bioethics, at Northwestern University’s Feinberg School monitoring of drugs in real time,” says lead author, Teepu of Medicine, who has written a book on hypochondria.

3 4 5 6 7 8

SEPTEMBER OCTOBER

RANK DEPARTMENT include grants awarded between Oct. 1, 3 OBSTETRICS AND GYNECOLOGY Another department, Neurological 2013, and Sept. 30, 2014. These rankings Surgery, will rank 15th after the NIH issues typically do not include contracts or other 4 DERMATOLOGY grant assignment corrections. specialized mechanisms. “Our faculty continue to outperform our “Our faculty represent top scientists, 4 PREVENTIVE MEDICINE peers in securing NIH funding in a national physician-scientists and innovators in environment where NIH funding has been their fields who rely on NIH support,” says 4 PHYSIOLOGY essentially flat for the past decade,” says Eric G. Neilson, MD, vice president for Rex Chisholm, PhD, vice dean of Scientific Medical Affairs and Lewis Landsberg Dean. 8 NEUROLOGY Affairs and Graduate Education. “This is a “These rankings reflect their successful reflection of the innovative research our 9 PHYSICAL MEDICINE AND pursuit of scientific discovery, conducted REHABILITATION faculty perform.” as they mentor and train the next genera- In the last decade, the NIH—the largest tion to likewise join biomedical research 15 NEUROLOGICAL SURGERY funder of medical research in the world— enterprise.” only funded about one in six of the grant INTERNAL MEDICINE The rankings record overall funding to 19 AND GERIATRICS applications it received. medical schools, as well as funding divided Overall, Blue Ridge ranked Feinberg by academic department. The ten depart- 19 OTOLARYNGOLOGY 22nd for NIH funding among all medical ments at Feinberg that rank among the top schools in the United States, higher than 20 in their area are: 20 CELL AND MOLECULAR BIOLOGY any medical school in Illinois.

WINTER 2014-15 13 ZERO ING IN

O N

2O14 ACTIVITIES

& ACCO MPLISHMENTS

...

“For the medical school, 2014 was a tremendous year,” said Eric G. Neilson, MD, vice president for medical affairs and Lewis Landsburg Dean. “Feinberg faculty published groundbreaking medical discoveries, while academic programs demonstrated continued excellence. We established a number of new and innovative programs and centers, recruited more world-class faculty and admitted students of the highest caliber. At the same time, the growth of the Northwestern Medicine health system cements our status as one of the nation’s premier academic medical centers. I look forward to another year of note- worthy research discoveries and academic distinction in 2015.”

The following stories spotlight some of the activities and accomplishments from the past year:

14 NORTHWESTERN MEDICINE MAGAZINE ACADEMIC NEWS BRAIN ABNORMALITIES LINKED ... TO CASUAL MARIJUANA USE Young adults who used marijuana MEDICAL SCIENTIST TRAINING PROGRAM only recreationally showed signifi- CELEBRATES 50 YEARS cant abnormalities in two key brain regions that are important in emotion and motivation, according to Hans Breiter, MD, a professor in psychiatry and behavioral sciences. The research collaboration between Northwestern Medicine and Harvard Medical School showed that the more joints a person smoked each week, the more abnormal the shape, volume In July, the Medical Scientist Training Program celebrated its and density of these regions. 50th anniversary with a poster session and reception attended by students, alumni and faculty. The weekend also ELECTRIC CURRENT MAY HELP TREAT served to welcome the 14 members of the incoming class. MEMORY DISORDERS More than 250 MD/PhD students have graduated from the Stimulating a particular region in the brain using magnetic medical school. While the first MD/PhD student attended in pulses improves memory. The discovery opens a new field the 1920s, the program started in 1964 when Northwestern of possibilities for treating memory impairments caused by became one of the three original universities to receive medical conditions and healthy aging. “We show for the first National Institutes of Health funding. time that you can specifically change memory functions in adults without surgery or drugs,” says Joel Voss, PhD, assis- ALUMNI SUPPORT SCHOLARSHIPS tant professor of medical social sciences. In fiscal 2014, more than 1,600 MD alumni pledged $19 million for new current-use scholarships and estate commitments. HEART ATTACK DAMAGE SLASHED Nearly 50 percent of medical students received scholarships After a heart attack, much of the heart muscle damage is and grants in fiscal 2014. caused by inflammatory cells that rush to the oxygen-starved tissue. But that destruction is halved when biodegradable FOURTH ANNUAL LES TURNER ALS SYMPOSIUM microparticles are injected into the bloodstream within 24 National and local ALS researchers, experts, doctors and hours, according to preclinical research from Northwestern patients gathered Dec. 11 at the Feinberg School of Medi- Medicine and the University of Sydney in Australia. “This is cine’s Fourth Annual Les Turner Symposium on ALS and the first therapy that specifically targets a key driver of the NeuroRepair. The event featured data blitz sessions by many damage that occurs after a heart attack,” says Daniel Getts, local ALS experts, a poster session and an “Ask the ALS a visiting scholar in microbiology-immunology at Feinberg. Experts” panel for patients. DRUG HALTS PROTEIN KNOWN TO AFFECT AGING In May, scientists published a study that identified a RESEARCH BREAKTHROUGHS protein’s key role in cell and physiological aging and (Unless otherwise noted, Northwestern Medicine have developed—in collaboration with Tohoku University scientists have made these discoveries.) in Japan—an experimental drug that inhibits the protein’s ... effect. In a mouse model, the experimental drug helped the rapidly aging mice live more than four times longer than a NEW GLAUCOMA CAUSE DISCOVERED control group, and their lungs and vascular system were Scientists have discovered a novel cause of glaucoma in an protected from accelerated aging, according to Douglas animal model and are now developing an eye drop to cure Vaughan, MD, chair of the Department of Medicine. the disease in humans. In glaucoma, pressure builds due to poor fluid drainage from the anterior chamber of the eye, HEART DISEASE WARNING AT AGE 18 eventually destroying the optic nerve. Susan Quaggin, MD, Elevated blood pressure as young as age 18 is a warning director of the Feinberg Cardiovascular Research Institute, sign that cardiovascular disease may develop later in life. and her team identified the molecular building blocks needed A 25-year large national study, led by Norrina Allen, PhD, to repair the eye’s plumbing. assistant professor of preventive medicine, is the first to

WINTER 2014-15 15 FEATURE: ZEROING IN ON 2014 ACTIVITIES AND ACCOMPLISHMENTS

delayed in fragile X. This may prevent the proper development of cells within the brain’s cortex.

TISSUE REGENERATION USING ANTI- INFLAMMATORY NANOMOLECULES The research group of Arun Sharma, PhD, research assistant professor in urology, works on innovative approaches to tissue regeneration to improve the lives of patients with urinary bladder dysfunction. The team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function.

POTENTIAL THERAPY FOR INCURABLE PEDIATRIC BRAIN TUMOR In November, scientists announced the discovery of a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation. Using an experimental drug called GSKJ4, they delayed tumor growth and prolonged survival in mice with diffuse intrinsic pontine glioma (DIPG). The disease occurs when tumors form in the brainstem, which controls breathing, heartbeat and motor and sensory pathways. “New therapeutic approaches are desperately needed,” says Rintaro Hashizume, MD, PhD, assistant professor in neurological surgery.

LONGER SURGERY MEANS HIGHER BLOOD CLOT RISK The longer the surgery, the higher is the risk of a life-threat- ening blood clot forming. This finding from a large-scale, national study will enable surgeons and patients to better understand potential risks. It may also spur surgeons to take more aggressive preventative measures such as prescribing a blood thinner and splitting up longer surgeries. “The trend is much more pervasive and consistent than any of us believed it could be, across all procedures, specialties and hospitals,” says John Kim, MD, associate professor in surgery- plastic and dermatology.

FIRST MOUSE MODEL FOR ALS DEMENTIA In September, scientists announced they had developed the first animal model for ALS dementia, a identify different long-term patterns of blood pressure levels form of ALS that also and resulting cardiovascular risk. damages the brain. The advance will allow research- SCIENTISTS FOCUS ON SYNAPTIC DEVELOPMENT ers to see the brains of living mice at the microscopic level, IN FRAGILE X SYNDROME under anesthesia. This will enable direct monitoring of test Northwestern Medicine scientists have identified events that drugs to determine if they work, according to Teepu Siddique, may contribute to delayed synaptic and neuronal development MD, professor in neurology and cell and molecular biology. in fragile X syndrome, the most common known cause of autism. Using mouse models, the lab of Anis Contractor, PhD, HOW MEMORY REWRITES THE PAST associate professor in physiology and neurobiology, discovered Our memory rewrites the past with current information, that the normal maturation of the neurotransmitter GABA is updating our recollections with new experiences. “When

16 MAGAZINE.NM.ORG you think back to when you met your current NEW TARGET FOR HUNTINGTON’S DISEASE THERAPY partner, you may recall this feeling of love In August, scientists announced the discovery of a new origin and euphoria,” says Donna Jo Bridge, a post- for the abnormal involuntary movements associated with doctoral fellow in medical social sciences. Huntington’s disease, a neurodegenerative disorder. “This “But you may be projecting your current degeneration was thought to be a consequence of impaired feelings back to the original encounter.” delivery of a survival signal to the striatum, a region of the forebrain controlling movement,” says D. James Surmeier, VITAMIN D DEFICIENCY LINKED TO PhD, chair of the Department of Physiology. “We show that AGGRESSIVE PROSTATE CANCER at least in the early stages of the disease…the problem stems African American and European American from a misinterpretation of the survival signal.” men at high risk of prostate cancer have greater odds of being diagnosed with an STOPPING THE SPREAD OF BREAST CANCER CELLS aggressive form of the disease if they The primary cause of death from breast cancer is the spread have a vitamin D deficiency, according to a of tumor cells to other organs. Scientists have identified a study from Northwestern Medicine and the new protein, hnRNPM, which plays a key role in reprogramming University of Illinois at Chicago. “Vitamin D cancer cells to migrate and invade other organs. When that deficiency could be a biomarker of advanced protein is removed, the ability of the cells to metastasize to the prostate tumor progression in large segments lung is dramatically decreased, according to Chonghui Cheng, of the general population,” says Adam B. MD, PhD, assistant professor in medicine-hematology/oncology. Murphy, MD, assistant professor in urology. RESTRICTING SURGICAL RESIDENTS’ HOURS PROTEIN MAY PROVIDE EARLY DOESN’T IMPROVE OUTCOMES BIOMARKER FOR PROSTATE CANCER Controversial restrictions on hospital residents’ duty hours Elevated levels of WDR5, a protein associ- imposed in 2011 did not improve surgery patients’ outcomes ated with cell cycle regulation, may allow or result in differences in surgical residents’ performance physicians to identify prostate cancer at its on exams. “Our large study of U.S. hospitals suggests that earliest stages. “If WDR5 is a driver protein, these latest restrictions may actually have the unintended we may be able to develop a compound that consequences of hurting patient safety, resident education would block a critical interaction and stymie and the doctor-patient relationship,” says Karl Bilimoria, MD, the disease,” says Debabrata Chakravarti, ’10 GME, director of the Surgical Outcomes and Quality PhD, professor of obstetrics and gynecology- Improvement Center. reproductive biology research. FINDINGS ON CAUSE, PROGRESSION OF ENDOMETRIOSIS Changes to two previously unstudied genes are the center- piece of a new theory regarding the cause and development of endometriosis, a chronic and painful disease affecting 1 in 10 women. The discovery suggests epigenetic modification, a process that enhances or disrupts how DNA is read, is an integral component of the disease and its progression. Matthew Dyson, PhD, research assistant professor of obstetrics and gynecology-reproductive biology research, and Serdar Bulun, MD, chair of the Department of Obstetrics and Gyn- ecology, also identified a novel role for a family of key gene regulators in the uterus.

RARE DISORDER MAY SHED LIGHT ON PARKINSON’S DISEASE By studying a genetic mutation in patients with a rare Parkinson’s-like disorder, scientists worked to understand the mechanisms behind the more common form of the disease. Dimitri Krainc, MD, PhD, chair of the Ken and Ruth Davee Department of Neurology, and Taiji Tsunemi, MD, PhD, research

WINTER 2014-15 17 FEATURE: ZEROING IN ON 2014 ACTIVITIES AND ACCOMPLISHMENTS

assistant professor in neurology, studied a mutation in LEADERSHIP the PARK9 gene, which is found in patients with Kufor-Rakeb APPOINTMENTS syndrome. “We found that lysosomes do not work properly in ... patients with PARK9 mutation, suggesting that PARK9 plays a role in normal function of lysosomes,” Dr. Krainc says. DIANE B. WAYNE NAMED VICE DEAN FOR EDUCATION RANKINGS AND HONORS In March, Northwestern ... University Feinberg School of Medicine named Diane B. RESIDENCY PROGRAM REGARDED AS ONE Wayne, ’91 MD, as its new OF NATION’S BEST vice dean for education. Dr. In February, the internal medicine residency program Wayne received her under- at McGaw Medical Center of Northwestern University was graduate and medical degrees named one of the most well-regarded postgraduate training from Northwestern as a member experiences in the U.S. McGaw was one of 10 programs to of the Honors Program in Medical receive more than 200 nominations in a national survey Education. She joined Northwestern’s conducted for U.S. News and World Report. medical school faculty in 1994. Most recently, she was vice-chair of the Department of FEINBERG RETAINS ELITE MEDICAL SCHOOL STATUS Medicine and associate chief medical officer Feinberg maintained its position among the best research- for Medicine, Women’s Health and Psychiatry oriented medical schools in the country, standing alone at at Northwestern Memorial Hospital. 18th in the annual U.S. News & World Report rankings. The school’s overall score rose to an all-time high for the fourth MCNALLY TO LEAD CENTER FOR consecutive year. GENETIC MEDICINE In July, the Feinberg School of Medicine NORTHWESTERN RANKS 14TH FOR HIGHLY CITED appointed Elizabeth McNally, MD, PhD, as RESEARCHERS the Elizabeth J. Ward Chair and director of Northwestern University ranked 14th for most highly cited the Center for Genetic Medicine. Dr. McNally researchers worldwide in a list compiled using data from most recently was at the University of Thomson Reuters. The researchers earned their placement by Chicago, where she served as the founding writing the greatest numbers of papers officially designated director of the Institute for Cardiovascular as highly cited—those ranking among the top 1 percent. Research, director of the Cardiovascular Genetics Clinic, and Carlson Professor of KIBBE NAMED EDITOR IN Medicine and Human Genetics. CHIEF OF “JAMA SURGERY” In August, Melina R. Kibbe, MD, NEW CHAIR OF BIOCHEMISTRY NAMED ’03 GME, was named editor In August, Ali Shilatifard, PhD, known for his in chief of the journal JAMA fundamental work in molecular epigenetics, Surgery, effective Jan. 1. “I hope was named chair of the Department of to provide surgeons with novel Biochemistry and Molecular Genetics. data and innovative concepts and approaches that challenge Shilatifard joined Feinberg from the Stowers current paradigms...,” says Kibbe, the Edward G. Elcock Institute for Medical Research. (See story Professor of Surgical Research in surgery-vascular surgery. on page 20.)

SHILATIFARD APPOINTED PLATANIAS APPOINTED DIRECTOR TO SENIOR EDITORIAL OF LURIE CANCER CENTER BOARD OF “SCIENCE” In October, Leonidas Platanias, MD, PhD, was In December, Ali Shilatifard, appointed director of the Robert H. Lurie PhD, chair of the Department Comprehensive Cancer Center of Northwest- of Biochemistry and Molecular ern University, a position served in interim Genetics, was appointed to the since January 2014. Dr. Platanias joined senior editorial board of the scientific journal Science. Feinberg in 2002. (See details on page 8.)

18 NORTHWESTERN MEDICINE MAGAZINE NEW DIRECTOR OF GALTER agent in Parkinson’s disease. The research is being conducted LIBRARY TO STRENGTHEN by Feinberg in partnership with the University of Rochester INFORMATICS Medical Center over five years. Kristi Holmes, PhD, a bioinfor- maticist with a background in NMHC AND CADENCE HEALTH REACH AGREEMENT research impact and genomic TO COMBINE SYSTEMS medicine, joined Feinberg in May In May, the governing boards for Cadence Health and Northwest- as director of the Galter Health Sciences Library and associate ern Memorial HealthCare approved the definitive agreement professor of Preventive Medicine-Health and Biomedical to combine the two health systems. Regulators approved the Informatics. Most recently, Holmes was at Bernard Becker merger in September, which created an integrated academic Medical Library at Washington University in St. Louis. healthcare delivery system spanning more than 60 sites of care across Chicago and its suburbs, including four hospitals, NEW NORTHWESTERN and more than 4,000 physicians and 17,600 employees. MEMORIAL HOSPITAL PRESIDENT NAMED LURIE CHILDREN’S RENAMES RESEARCH INSTITUTE In January, Northwestern Ann & Robert H. Lurie Children’s Hospital of Chicago announced Memorial HealthCare (NMHC) a major philanthropic gift from retired local business executive named Richard J. Gannotta, DHA, Stanley Manne. In recognition, the hospital’s research center FACHE, president, Northwestern will be renamed the Stanley Manne Children’s Research Memorial Hospital and senior vice president, NMHC. Gannotta Institute. The confidential gift, the second largest in the was previously president of Duke Raleigh Hospital. hospital’s history, will help sustain and enhance medical research at the 130-year-old institution. LIEBER NAMED RIC’S SENIOR VP OF RESEARCH, CHIEF SCIENTIST GALA CELEBRATES LAUNCH OF NORTHWESTERN Richard Lieber, PhD, MBA, an expert in the physiology and MEDICINE CAPITAL CAMPAIGN biomechanics of skeletal muscle, was named senior vice Nearly 950 faculty, staff, students, alumni and friends president of research and chief scientist at the Rehabilita- gathered at Navy Pier in May to celebrate the launch of We tion Institute of Chicago (RIC). Lieber has spent his entire Will. The Campaign for Northwestern Medicine. The Feinberg academic career at the University of California-San Diego, School of Medicine and Northwestern Memorial Foundation where he served as vice chair of Orthopaedic Surgery, are working to raise $1.75 billion to provide crucial resources professor of bioengineering and director of the National that will increase innovation and excellence. As of Dec. 31, Center for Skeletal Muscle Rehabilitation Research. nearly $927 million has been contributed by 13,705 donors.

LES TURNER ALS FOUNDATION COMMITS NOTABLE ANNOUNCEMENTS $10 MILLION FOR NEW CENTER ... In September, the Les Turner ALS Foundation made a $10 million commitment to create the Les Turner ALS Research and SCIENTISTS WORKING TO LINK MEDICAL RECORDS Patient Center at Northwestern Medicine to accelerate research IN CHICAGO and advance patient care in amyotrophic lateral sclerosis (ALS), A novel computer application developed by Northwestern also known as Lou Gehrig’s disease. The Center will bring ALS Medicine scientists could change the way cities track disease research, clinical and education activities under one umbrella. and epidemiologists approach future research. Led by Abel Kho, MD, MS, assistant professor of medicine-general internal medicine and geriatrics and preventive medicine-health and biomedical informatics, the collaborative effort was awarded a $7 million grant.

NORTHWESTERN STUDY TO TEST PARKINSON’S DRUG Tanya Simuni, MD, medical director of Northwestern Univer- sity’s Parkinson’s Disease and Movement Disorders Center, was awarded a grant from the National Institutes of Health to conduct a $16 million phase III study of the safety and efficacy of the drug isradipine as a potential neuroprotective

WINTER 2014-15 19 Ali Shilatifard, PhD, started assisting WRITTEN BY: Martha O’Connell PHOTOGRAPHY BY: Bruce Powell in his grandfather’s lab in Tehran at age 5. Years later, Northwestern lands this acclaimed scientist to lead the new Department of Biochemistry and Molecular Genetics and halt cancer.

Curious Kid, Unconventional Scientist

20 MAGAZINE.NM.ORG To some, a young boy in a high-science lab is like a bull in a china shop, but Shilatifard absorbed it all, and turned a childhood fascination into a productive career. He realizes that this extraordinary opportunity early in his upbringing sparked a disciplined mind and fueled the drive to pursue his ideas. He goes by “Shilati” for short and in September brought his groundbreaking work in molecular epigenetics to Northwestern University Feinberg School of Medicine as chair of the new Department of Biochemistry and Molecular Genetics and the Robert Francis Furchgott Professor of Biochemistry. Shilatifard is energetic and steadfast in pursuing his ideas on how chromosomal translocation (when a chromosome breaks and a portion of it reattaches to a different chromosome) and misregu- lation of gene expression causes childhood leukemia. At first, some of his theories were very unpopular and other scientists voiced strong doubts. He still remembers being cynically questioned when he began his investigations in the late 1990s.

WINTER 2014-15 21 FEATURE: CURIOUS KID, UNCONVENTIONAL SCIENTIST

JAY SINGH, A RESEARCH TECHNOLOGIST, SETS UP ONE OF THREE MARC MORGAN, A POSTDOCTORAL FELLOW, REVIEWS SCIENTIFIC IMAGES CENTRIFUGES TO EXTRACT DNA. THAT REFLECT RESEARCH DONE IN THE SHILATIFARD LAB. THE RED AND GREEN IMAGE EXPRESSES CANCER-ASSOCIATED HISTONE H3.3 LYSINE 27 IN A DROSOPHILA MELANOGASTER (COMMON FRUIT FLY) WING.

Now after 20 years of intense research, he has received major To unravel the mystery of MLL, he went validation from the scientific community as hundreds of labs and against conventional thinking because he medical journals jump on the bandwagon, recognizing the role that felt so strongly that the protein played a transcriptional elongation control plays in development and that key role in gene regulation. Shilatifard cancer results when this process is misregulated. studied Saccharomyces cerevisiae, better “What we proposed so long ago turned out to be right: tran- known as single-cell yeast. “All of my scriptional elongation control is central to leukemic pathogenesis,” colleagues at the medical center thought Shilatifard says. “It feels fantastic to me that this model is correct.” we were nuts! They could not understand what yeast cells have to do with studying START WITH SIMPLE STUFF human diseases, specifically childhood In the 1990s, he was deep into molecular HIV studies and leukemia,” he recalls. purifying proteins and enzymes when he realized he wanted to Ignoring naysayers, the biochemist know more than the molecular structures before him—he wanted climbed up the ladder of life, starting with to learn how they function. Since then, his team has made yeast to fruit flies (Drosophila) to vertebrates, multiple discoveries about how proteins and enzymes work a strategy that made it easier to uncover together in gene expression, zeroing in on chromosomal abnor- what turns genes on or off in humans. His malities that cause cancer. research led to identification of a protein As a Jane Coffin Childs postdoctoral fellow at the Oklahoma complex he named “Set1/COMPASS,” which Medical Research Foundation, he purified and identified the functions as a signaling pathway to activate function of ELL, a protein that regulates gene expression. This or deactivate gene expression. sparked his interest to understand transcription elongation, the In 2010, a major breakthrough came process by which the nucleic acid RNA is made. when Shilatifard’s laboratory identified At the time, it was known that ELL and MLL, another gene that a large group of proteins and enzymes regulates cell development, are translocated or “flipped” on to that control transcription elongation, incorrect chromosomes in children with certain subtypes of aggres- the Super Elongation Complex (SEC). The sive leukemia. Shilatifard theorized that once these genes flip the SEC includes ELL and many other proteins elongation process that controls RNA building does not occur correctly. that fuse with MLL, and when MLL is

22 NORTHWESTERN MEDICINE MAGAZINE translocated into other partner genes, area institutions. The chance to work In addition, he takes a cue from Arthur the whole SEC follows and gene expres- with experts at the Robert H. Lurie Kornberg, MD, the 1959 Nobel Prize winner sion goes awry. Comprehensive Cancer Center of North- for his research in DNA synthesis. Shilatifard Based on his fundamental molecular western University, designated as one of was fascinated by Kornberg’s work in studies, Shilatifard says that transcriptional the nation’s best by the National Cancer enzymology and hopes to partly model elongation and how it regulates gene Institute, was also very attractive to him. Feinberg’s new department after Kornberg’s expression will be valuable in solving other “I get to chair a large department, work Department of Biochemistry at Stanford types of cancers and human diseases, too. with other chairmen, recruit young faculty University, a highly integrated group “Now we are really ready and eager to and help them develop their careers. That working in close proximity where communi- make drugs that will target genes associ- is very satisfying to me. I want to inspire cation between teams is the standard. ated with cancer. So much has come full and guide the next generation of scien- He also looks up to William Sly, MD, circle, and we are ready to hit the throttle tists.” He adds, “I have four kids, so I am Shilatifard’s chairman while he was in St. and move this forward,” he exclaims. a bit paternal.” Louis whom he also calls his “scientific father.” Sly was elected to the National Academy of Sciences for his groundbreaking work in metabolic disorders. “I will move slowly and very selectively “Now we are really ready to get the best people from different disciplines,” Shilatifard adds. “I have not and eager to make drugs chosen those disciplines yet, but these people have got to be the best, and they that will target genes must be highly collaborative.” At home, he is nurturing four children: associated with cancer” Anthony, 12, Joseph, 15, Natalie, 17, and Francesca, 18, who not surprisingly is studying biology in college. They are a multi-lingual family, with six languages FATHER FIGURE Sharing the excitement that their spoken between him and his wife Laura, At age 14, Shilatifard was sent alone to research is ahead of its time, Shilatifard’s including Shilatifard’s native Farsi. Turkey and then to the United States for a lab team followed him to Chicago from Sharing his dedication to move science good education. He earned an undergradu- the Stowers Institute for Medical Re- forward, Laura, a former oncology and ate degree in organic chemistry from search in Kansas City, Mo., where he was pediatric endocrinology nurse, is the lab’s Kennesaw State University, and holds a grateful to be supported by excellent core editorial assistant. She proofreads and doctoral degree in biochemistry from the research experts and facilities and other manages papers and grants, helps organize University of Oklahoma. generous resources. conferences and meetings, and manages Later on, he established his indepen- Motivated by pioneers in his field, manuscripts her husband handles as editor dent lab at Saint Louis University’s School Shilatifard picks up the torch from influen- for three journals: Molecular and Cellular of Medicine, where he discovered Set1/ tial people in his life to continue breaking Biology, eLife, and Science Advances. (He COMPASS. He realized that genetics was genetic patterns that cause cancer. was also recently named to the senior becoming very central to his work and he His grandfather, Ahmed Pezeshkmehr, editorial board of the journal Science.) needed to quickly grasp its concepts, so an Iranian physicist and radiologist, laid He also serves on numerous scientific he largely taught himself, with assistance the scientific foundation by instilling in boards, including the Max-Planck Society from Mark Johnston, PhD, who was the him a love for education, experimentation and Genentech, is principle investigator chair of genetics at Washington Univer- and medicine. for three R01 grants, and has received sity’s School of Medicine. The University of Chicago’s (U of C) numerous honors. Shilatifard has become a firm believer late Janet Rowley, MD, a globally acclaimed After his family, his second love is his that medical investigation should be done physician-researcher whose pivotal work science, and he is smitten. Now at age 48, as a community. He came to Chicago for established the link between genetics and he lives and breathes his research and is the opportunity to partner with other cancer, motivated Shilatifard to persist creating a world-class department. There scientists and physicians to accomplish with his ideas. In the spirit of her work, he is little time for anything else. translational medicine with Northwestern hopes to increase collaboration with U of C “This is it!” he says with exuberance, Medicine’s four hospitals, the university’s researchers to expedite breakthroughs in fist-pounding his desk. Evanston campus, and with other Chicago- patient treatments.

WINTER 2014-15 23 New outpatient facility meets WRITTEN BY: Cheryl SooHoo PHOTOS BY: Northwestern Memorial HealthCare growing healthcare trend >

19-24 PHYSICIAN SUITES 17 DIAGNOSTIC CENTER • IMAGING (MRI AND CT) • PRE-OPERATIVE CLINIC • X-RAY • ULTRASOUND • LABORATORY SERVICES 13 THE CENTER FOR COMPRE- HENSIVE ORTHOPAEDIC AND SPINE CARE (CCOSC) 12 OUTPATIENT SURGERY CENTER CENTRAL STERILE SUPPLY 10 STAFF LOCKERS AND LOUNGE 3-9 PATIENT/VISITOR PARKING 2 AU BON PAIN KIOSK BERCO’S POPCORN GATEWAY NEWSTAND HOW DO YOU ROLL (SUSHI) OPTICAL SHOP BRIDGES TO FEINBERG PAVILION AND EXTERNAL PARKING GARAGES 1 COSÌ LYFE KITCHEN STAN’S DONUTS L DEDICATED LOADING DOCK LOWER CONCOURSE CON- NECTION TO FEINBERG

24 MAGAZINE.NM.ORG See video about the Center for Comprehensive Orthopaedic and Spine Care (CCOSC) online at magazine.nm.org.

QUALITY CARE BY DESIGN

259 One-stop shopping has risen to greater heights—precisely 25 > stories—at Northwestern Medicine. In mid-October, the Chicago E. ERIE medical campus welcomed the opening of a new leading-edge ambulatory care facility. The high-rise at 259 E. Erie, known as 25 the “259 Pavilion,” houses every convenience a patient could > need, from doctor’s offices and imaging services to an outpa- STORIES tient surgery center and even a trendy Stan’s Donuts shop, one of several retail offerings. 7 At the corner of Fairbanks Court and Erie Street, the sleek > modern structure is also home to a newly created Northwest- LEVELS OF ern Center for Comprehensive Orthopaedic and Spine Care PARKING (CCOSC). The center features a multidisciplinary mix of musculoskeletal experts, representing six subspecialties. 6 Patients receive all their care from myriad specialists based > on the same floor of the building. In the past, orthopaedic EATERIES patients had to traverse as many as five different facilities on the hospital campus to access the same medical and rehabilitative services now found in one location. “We were in silos and separated from other disciplines,” says Terrance Peabody, MD, Edwin Warner Ryerson Professor of Orthopaedic Surgery and chair of the Department of Orthopaedic Surgery at Northwestern University Feinberg School of Medicine. “I don’t know of any other comprehensive musculoskeletal center of this kind in the Chicago area.”

WINTER 2014-15 25 FEATURE: QUALITY CARE BY DESIGNDNA SEQUENCE OF EVENTS

The opening of the 259 Pavilion Symbolizing healing and medicine, the artwork expresses comes at a turning point in the delivery of a subtle, soothing calm much like that of the building. “A care. Factors such as the Affordable Care smaller, less imposing space, the facility was people-engi- Act and integration of health systems neered to provide a more pleasant environment for our across the country have shifted priorities patients,” says David W. Manning, MD, ’98 GME, associate for providers, payers and most impor- professor of orthopaedic surgery, who assisted with the tantly, patients whose satisfaction is building’s design. “From beginning to end, they receive paramount in an increasingly competitive efficient high-end care in a distinctively quieter and less marketplace. Five years in the making, chaotic clinical setting.” this latest facility was built to meet Intended to serve individuals with compromised increasing demand for more affordable mobility, especially after outpatient surgery, the build- ambulatory care outside the confines of ing’s internal structure ensures that the journey to the typical hospital environment. Ironi- quality medical services begins with the fewest steps cally, it was a need for more inpatient bed possible. At 259, the path to care starts with in-building capacity at Northwestern Memorial parking—a luxury in congested urban Chicago. The Hospital (NMH) that drove initial planning elevators of the seven-level parking structure with 564 discussions in 2008. At that time, NMH spaces deliver visitors to a second-floor atrium with an intended to convert doctors' offices in information desk staffed 24/7 by customer service its historically outpatient Galter Pavilion officers. A separate bank of elevators, serving floors one to inpatient bed space—an expansion to 17, takes patients to clinical areas. Level 17 works as completed in 2011—which would create the crossover floor to elevators that service the 17th to a “medical office crunch.” 25th floors, where the upper half of the facility focuses “259 was originally going to be a on medical office space. The 17th floor also houses the traditional professional building,” explains Diagnostic Testing Center, which provides preadmission > Jim Mladucky, director of Facility Plan and Construction for Northwestern Memorial HealthCare. An architect specializing in healthcare, planning and design, he led BELOW: THE AMBULATORY SURGERY CENTER HAS 8 OPERATING ROOMS BUILT TO ACCOMMODATE several focus group sessions with physi- SPACE-INTENSIVE ORTHOPAEDIC PROCEDURES. cians, staff and community members over many months to determine what type of facility would help Northwestern Medicine best serve a variety of patients. “While still accommodating medical office space, the building concept morphed quite a bit to become what it is today and what it can become in the future.” Mladucky credits physician feedback for the integrative care model now showcased by the building’s first anchor tenant: the CCOSC. “Their input shaped our building design approach, which was to focus on disease systems rather than clinical departments,” he says. “The musculoskeletal clinical offering quickly came to the surface as the best fit for this new venture.”

CONVENIENT EFFICIENCIES An abstract titanium sculpture of the rod of Asclepius, depicted by a serpent coiled around a staff, hangs from the ceiling of the two-level lobby of the 259 Pavilion.

26 NORTHWESTERN MEDICINE MAGAZINE testing, electrocardiography services and phlebotomy. The building features advanced diagnostic imaging, including an innovative full-body, low-dose orthopaedic “EOS” scanner, the only one in Illinois and one of a few in the country, as well as the highest MRI in North America from street level. Says Nick Wojciechowski, project director during 259’s construction, “That’s an important distinction as Denver would have us beat!” The Ambulatory Surgery Center on the 12th floor features eight operating rooms sized to accommodate space-intensive orthopaedic procedures as well as a 28-bay recovery area. It also provides a discreet “back door” for patients who’ve undergone procedures and may not feel up to traveling through the building’s public spaces upon discharge. “Once individuals are ready to leave, their designated drivers drive up to the 9th floor parking deck,” explains Wojciechowski. “Staff members take the patients, via employee service elevators, down three floors where they meet the family members or friends at their car.” Located in vibrant Streeterville, Northwestern Medicine’s downtown clinical facilities serve many constituents, including employees, neighbors and even tourists. In recent months, Northwestern Memorial has transformed its shopping and dining space by literally opening doors, with retail entrances now accessible from the street as well as the hospital. The new ambulatory care facility has followed suit with restaurants and stores on the first and second floors. In early 2015, patients and visitors will have a choice of two more eating establish- ments: LYFE Kitchen, a fresh food company that supports local farms, and How Do You Roll, a fast-casual sushi franchise. “Appropriate retail provides a comforting distraction when you are going through a difficult time,” says Gina Weldy, vice president for real estate, NMHC. “People want a respite that helps them feel like they aren’t in a medical facility. Dining options and shops provide variety and convenience for patients while they’re on our campus.” The building also houses a Walgreens store that sells durable medical equipment—handy items for orthopaedic and other outpatient surgery patients. Complementing future medical services, an optical shop opened in November. “These amenities serve many purposes,” adds Weldy. “For example, retail TOP: THE NEW OUTPATIENT PAVILION OFFERS A FULL- complements way-finding. When following directions, it’s easier for people to BODY, LOW-DOSE ORTHOPAEDIC “EOS” SCANNER, THE remember to go Au Bon Pain and take a left than it is to turn left just past the ONLY ONE IN ILLINOIS AND ONE OF A FEW IN THE imaging department.” COUNTRY. BOTTOM: ARCHITECTURAL ELEMENTS LIKE THE ABSTRACT TITANIUM SCULPTURE OF THE ROD OF LUCKY 13 ASCLEPIUS, DEPICTED BY A SERPENT COILED AROUND On the 13th floor of the 259 Pavilion, the 41,000-square-foot Northwestern A STAFF, HANGS FROM THE TWO-LEVEL LOBBY. Center for Comprehensive Orthopaedic and Spine Care opened October 13. So far the numbers of patients seen by the approximately 35 providers of the center have all been good, if not overwhelmingly great. “Our biggest challenge has been handling the volume,” says Dr. Peabody. “It ramped up very quickly and initially taxed our ability to check-in patients, but we’re smoothing out the kinks.” Plans are now underway to emulate the CCOSC Championing a truly collaborative care model, the CCOSC intends to demon- model. The 16th floor will become home to a strate that the physical proximity of specialists all focused on a defined set of Center for Digestive Health that will include GI lab disorders or conditions results in better, cost-effective patient care. The first screening procedures. Currently, these clinical and step in that direction? Putting systems in place that ensure people see the laboratory services operate on different floors at right doctor for the right ailment. opposite ends of the hospital. “If you are having back pain and don’t need surgery, you shouldn’t be About 30 percent full at its grand opening, the seeing a spine surgeon,” says Dr. Peabody. “At the Center, we have triage new facility continues to grow with construction protocols that improve efficiency. The beauty of being all together is that we on nine of 12 available floors slated through the can quickly make sure a patient sees the appropriate provider as well as deliver end of 2016. Like its new sushi restaurant, the same-day service.” 259 Pavilion is on a roll.

WINTER 2014-15 27 WARD ROUNDS® NEWS

Alumni President’s Message

Dear Fellow Alumni: students in the fall. It is a great way for evening, reunion class dinners on Saturday alums to interact with students in an night, and family-friendly activities like our As we move on to informal social setting. After dinner, each second annual Family Fest and lunch. The the year 2015, I am of the students described their background Medical Alumni Association Board Meeting pleased to report and potential career interests. What an will also be held that weekend on Saturday, that your Medical Alumni Association Board, through its four working committees: Engagement, Mentoring, Strategic Initia- tives and Fundraising, has maintained momentum since the Board was reorga- nized in 2013. The alumni volunteer Board members and Executive Committee have done a tremendous job, but let’s not forget the leadership contributions of Vice Dean Alan Krensky, MD; ML Farrell, director of Alumni Relations; and staff. In my fall 2014 President’s Report, I highlighted the vital role played by the four Feinberg Student Societies: Cooper, Ricketts, Thompson and Law- less. A new mentoring program, “Real Physicians of Feinberg,” connects our medical students with alumni. The first alumnus, Bohdan “Bud” Wasiljew, ’76 MD, ’81 GME, happily volunteered to meet with ALUMNI BOARD PRESIDENT DAVID WINCHESTER (SEATED ON RIGHT) AND HIS WIFE MARILYN HOSTED interested members from each of the four 13 MEDICAL STUDENTS IN THEIR HOME IN THE FALL. societies. Bud is a recently retired general surgeon who answered students’ ques- experience it was for us to observe these April 18. That is an open meeting and, if tions about how to choose a specialty, bright, dedicated young men and women interested, you are welcome to attend. among other topics. articulate their enthusiasm for a career in And finally, this will be my last Alumni Kevin Wang, M2, one of the attendees medicine. I am certain that my fellow alums President’s Report. It has been an honor and from the Thompson Society, wanted to would derive the same enjoyment from this a privilege to serve in this leadership role, learn more about balancing his personal type of event. In fact, several other alumni and I look forward to continuing to partici- and professional life. He observed that the already have, or will be, sponsoring similar pate on the Medical Alumni Board as past meeting with Dr. Wasiljew enabled him to events, coordinated through the Office of president. I will be handing over the gavel better appreciate “meeting this balancing Alumni Relations. If you’d be interested in to President-elect, Bruce Scharschmidt, ’70 challenge after medical school and finding hosting students, please contact ML Farrell MD, in April, and I wish him the best as he personal fulfillment in his future career.” in Alumni Relations. continues to build on our momentum. A variation on this theme of connecting Also, let me remind and encourage you with students is for Feinberg alumni in the to attend Alumni Weekend April 17 and Chicago area to host a dinner for interested 18. New this year will be an all-alumni All the best, medical students. My wife Marilyn and I had welcome reception with reunion class the pleasure of holding a reception and recognition and presentation of the David Winchester, ’63 MD dinner at our home for 13 first-year medical Distinguished Alumni Award on Friday Alumni Board President

28 MAGAZINE.NM.ORG Progress Notes Simon K. Myint ’53 MD, served in the USAR Medical Corps as a lieutenant colonel at the former 828th Station Hospital in Fresno, Calif. He was on active duty for five months during EDITOR’S NOTE: Desert Storm in 1991, and was then promoted to full colonel. Dr. Myint also served in WE CONTINUE OUR COVERAGE OF ALUMNI WHO ARE Aberdeen, Md., the Maldives, Camp Bullis MILITARY VETERANS. at Ft. Sam Houston, Texas, Ft. Huachuca, Arizona, and Camp Pendleton, California.

KEY: Arnold “Arnie” L. Widen, ’53 MD, ’55, ’59 GME, served in the U.S. Armed Forces, as did all of AFB AIR FORCE BASE the male members of his class who had not ASTP ARMY SPECIALIZED TRAINING PROGRAM – ESTABLISHED already served before medical school, since a DURING WWII AT UNIVERSITIES TO MEET DEMANDS FOR physician draft was still in effect. He served JUNIOR OFFICERS AND SOLDIERS WITH TECHNICAL SKILLS in the U.S. Army Medical Corps, on active HPSP HEALTH PROFESSIONS SCHOLARSHIP PROGRAM duty from Jan. 1, 1956, through Dec. 31, 1957, ICBM INTERCONTINENTAL BALLISTIC MISSILE and then in the active reserve for an LST LANDING SHIP TANK additional four years. Dr. Widen has very LTC LIEUTENANT COLONEL positive memories and attitudes about his LTCDR LIEUTENANT COMMANDER Army medical service, since he served during MC MEDICAL CORPS a time of peace, and his medical duties MP MILITARY POLICE contributed significantly to his overall NAVY COLLEGE TRAINING PROGRAM ESTABLISHED experiences as a physician. (More online.) V-12 TO PROVIDE THE NAVY WITH A CONTINUOUS SUPPLY OF OFFICERS Edmond Eger II, ’55 MD, co-edited “The SAC STRATEGIC AIR COMMAND Wondrous Story of Anesthesia” (Springer, USAF U.S. AIR FORCE 2014), a 944-page book describing the USAR U.S. ARMY RESERVES history of anesthesia. USMC U.S. MARINE CORPS USNR U.S. NAVY RESERVES Robert G. McKillop, ’56 MD, was accepted to attend medical school at the University of South Dakota in 1950, but was drafted into ’50s the U.S. Army from Dec. 1950 until Aug. 1952, finally starting medical school in Frank Frable, ’51 MD, decided to practice medicine after hearing a radio broadcast Sept. 1952. While in the Army, he went about sulfa drugs in 1935. He was drafted on June 1, 1944, accepted to the through infantry basic training and later, medical school on Oct. 1, 1944, and discharged on June 15, 1946. He was an medic training. He was not sent to Korea electronics technician, mate 3c, stationed at the U.S. Navy Research Laboratory and became a dental assistant, eventually in Washington, D.C. He also worked at the Underwater Sound Laboratory in New getting an early discharge to attend London, Conn., and the torpedo range in Piney Point, Md. (More online.) medical school. This was followed by an internship in Chicago and an orthopaedic Sam Koide, ’53 MD, ’58 GME, sent the following timeline of his military training residency at the Mayo Clinic. He started and service: private practice in Portland, Ore., in 1962, » Feb. 12, 1945: inducted U.S. Army, private, infantry, Schofield Barracks, Hawaii with gradual retirement ending in 2005. » Feb.-Aug. 1945: Basic infantry training, Ft. McClellan, Alabama Dr. McKillop’s retirement activities include » Aug.-Dec. 1945: Infantry Officer Training, commissioned as 2nd lieutenant, watercolor and acrylic painting and singing Ft. Benning, Georgia in a men’s chorus. » Jan.-June 1946: Military Language School, Ft. Snelling, Minnesota » Aug. 1946-Feb. 1948: War Crimes Division, Military Intelligence Service, G. Stephen Scholly, ’56 MD, served as a SCAP (Supreme Commander of the Allied Powers), Manila, Philippines general medical officer in the U.S. Navy » March-July 1948: Interpreter, Civil Service Section, Yokohama, Japan from l957 to 1959, consisting of 18 months (More online.) of sea duty and six months of shore duty.

WINTER 2014-15 29 WARD ROUNDS® NEWS: PROGRESS NOTES

During those last six months, he was in the reserve until 1980. He trained in a of the ‘doctor draft.’ stationed at an 80-bed clinic/hospital at military hospital with two years as flight After the Berlin Wall Patuxent River, Md., where he shared the surgeon and chief of Aerospace Medicine at and the Cuban Missile inpatient ward with another physician who Sheppard AFB, Texas. He served in England Crisis, Uncle Sam had internal medicine residency training. It and in Texas until 1971. The last three pulled me out of was this hospital-based experience that years on active duty were at Wilford Hall residency and ordered influenced his career choice of internal Medical Center, San Antonio, as training me to active duty as medicine and later, pulmonology. officer in the residency program. After a captain in the USAF. leaving the Air Force, he served in the I was stationed at Altus AFB, Oklahoma, Dan M. Henshaw, ’57 reserve at Hill AFB and Scott AFB until June where I was chief of internal medicine. MD, was part of the 1980, when he retired. Stanley ‘Stan’ Englander, ’59 MD, was the U.S. Army Senior base pediatrician and we became good Program during his George Kaplan, ’59 MD, ’66 MS, ’73 GME, friends. I returned to residency in July 1965, last year of medical served three years as a general medical just before the troop build-up started in school and was officer in the U.S. Navy after his internship. Southeast Asia. In 1968, I received an commissioned as a He was first assigned to an LST Squadron honorable discharge. I had a good second lieutenant in and then was transferred to an APA (Attack experience in military service. It gave me July, prior to his senior year. He was Transport) that spent nine months in the two years of practical experience in clinical promoted to first lieutenant during his Western Pacific, just before the onset of medicine, and I felt like I genuinely helped internship at Charity Hospital in New the Vietnam War. The APA had a crew of the airmen and their families.” Orleans and then entered active duty. His about 300 and carried as many as 1,500 initial assignment was Ft. Sam Houston, marines. Dr. Kaplan then spent two years Robert M. Vanecko, ’61 MD, served as a Texas, followed by two years in Europe, at the Naval Training Center San Diego, captain in the USAF from 1967 to 1969, and prior to his dermatology residency at the also as a general medical officer. He writes, was assigned as the chief of surgery at Walter Reed Military Medical Center. He “I think the experience was maturing and, Homestead Air Force Hospital, Homestead, served as a physician in the Army and Air as a result, I got a lot more out of my Fla. This was an SAC Base and the Sea Force for a combined total of 28 ½ years, residency than did those who had gone Survival School and Combat Training Center including with the 106th General Hospital directly from internship to residency.” for personnel assigned to Vietnam. during Vietnam and the 317th Contingency Hospital during Operation Desert Storm. John Romine, ’59 MD, served many years in Howard N. Ward, ’62 MD, served in the While serving in the USAF, he taught the military, beginning as a Navy Reservist USAF from July 11, 1966, to July 9, 1968, at medical students, interns and residents, in 1957. From 1959 to 1962, he was the 838th Tactical Hospital, Forbes Air and was twice voted “Teacher of the Year” stationed at a Marine Corps base, Camp Force Base, Kansas, as captain in the by the students. (More online.) Pendleton, California. From 1962 to 1965, he Medical Corps. During this service, he was had a Navy residency in orthopaedic chief of internal medicine, director of Theodore “Ted” surgery, with a two-year fellowship in professional services and deputy hospital Englehorn, Jr., ’58 MD, children’s orthopaedics at Indiana University commander. He also served 30 days of served in the U.S. Army to follow. From 1966 to 1967, he served as temporary duty (Sept. 1967) at Incirlik Air Medical Corps from an orthopaedic surgeon for the 3rd Medical Base, near Adana, Turkey, as the medical Oct. 1960 until Oct. Battalion, USMC, in Vietnam, and then from support for a NATO paratrooper exercise. 1962. He spent two 1967 to 1970 at the U.S. Naval Hospital, years on active duty as Naples, Italy. From 1970 to 1972, he was the Richard M. Heller, ’63 an obligated volunteer chief of orthopaedics at Naval Hospital, MD, was a physician in at the 225th Station Hospital, Muenchweiler, Great Lakes, Ill. He finished his military the Air Force from July Germany. His military occupational specialty career as an Army reservist from 1987 to 1, 1964, to June 30, was D3150 general surgeon (one year 1995, including being called back for Desert 1966. He was a residency). His shoulder patch was the Storm in 1991. He retired in 1995. general medical flaming sword of U.S. Army Europe and his officer assigned to rank was captain. (More online.) Izmir, Turkey, for 19 ’60s months and then Wright Patterson AFB, Perry T. Roberts, ’58 MD, joined the Air Dayton, Ohio, for five months. After leaving Force during his last year of medical school Kevin Glynn, ’61 MD, writes: “Like most the Air Force, he completed a radiology and served continuously on active duty and physicians from the Cold War era, I was part residency at Massachusetts General Hospital

30 NORTHWESTERN MEDICINE MAGAZINE and a fellowship in pediatric radiology at at the Marine Corps retiring as a colonel 06 in 2000. Boston Children’s Hospital. He joined the Base, Camp Lejeune, Dr. Pickard was elected national radiology faculty at Johns Hopkins, and then North Carolina, and commander of the Jewish War Veterans of in 1975, Vanderbilt University Medical then deployed to the the USA (JWV) at its 118th Annual National Center, where he founded the section Republic of Vietnam to Convention in Richmond, Va., on Aug. 23, of pediatric radiology and the pediatric serve as an anesthesi- 2013. He comes from a JWV family. His radiology clerkship. (More online.) ologist with Delta father, Ted, was department commander of Company, First Medi- Illinois and his mother, Lena, was president William F. De Rose, ’64 cal Battalion of the First Marine Division in Da of the Illinois JWVA. (More online.) MD, served in the Nang, Chu Lai, and Phu Bai from 1967 to 1968, Army Medical Corps a period that included the TET Offensive. After Gerald “Jerry” Halpern, ’65 MD, ’72 GME, from 1966 to 1968. completion of his overseas tour, he was sent writes, “My father, Sam Halpern, ’28 MD, He entered the to the Naval Hospital, Newport, R.I., where was in the first graduating class of the service after complet- he ended his career as a Navy medical officer Northwestern University medical school. ing a year of intern- with the rank of lieutenant commander. I was in the first six-year program class in ship and one year 1961 as a college graduate (Cornell) with of a residency in internal medicine at Charles S. Wilson, ’64 MD, served in the a research background. It was with life- the University of Iowa Hospital. He was Army Medical Corps from July 1965 to July changing luck that Dr. Grayhack accepted me stationed at Ft. Benning, Georgia, his first 1968, attaining the rank of major, MC, as a resident in his urology program in 1966. year of service and worked in the outpatient USAR. During that time, he served as After two years in the U.S. Army at Ft. department at Martin Army Hospital. He battalion surgeon, 4th Infantry Division, Benning, Georgia, as chief of urology at spent his second year in Vietnam assigned at Ft. Lewis, Washington, 1965 to 1966, Martin Army Hospital, I started in private to the 37th Medical Company of the 11th and as medical officer, U.S. Army 5th Field practice in South Florida. There, my wife, Armored Cavalry Regiment as the com- Hospital in Thailand, 1966 to 1968. After he Lauren Rosen Halpern (U. of Michigan manding officer. As such, he spent more left the military, he completed his residency 1966), and I raised our three children.” time in administrative work and military in internal medicine and a fellowship in (More online.) matters than in medicine. (More online.) cardiology at Mayo Clinic from 1968 to 1972. From 1972 to 2012, he was in a Frederick Dean, ’66 MD, served as captain Richard Dedo, ’64 MD, ’69 GME, served from cardiology private practice in Lincoln, in the Army Medical Corps from June 1967 1957 to 1960 as a navigator/radar intercept Neb., retiring in 2012. to June 1969, serving 15 months in Incheon, officer on an F-101B Voodoo, a two-man Korea, and the remainder at Ft. Bragg, fighter-interceptor, which carried two Robert E. Pickard, ‘65 North Carolina. air-to-air atomic missiles and two heat MD, ‘00 BSM, interned seeker missiles. From 1960 to 1970, he at the University of Stephen Kwedar, ’66 MS, ’66 MD, served as completed his medical school and residency Miami at Jackson a major in the USAF as an ophthalmologist training while in the Air Force Reserve, and Memorial Hospital from 1970 to 1972. He was stationed in then from 1970 to 1980, he was in the after graduating from U-Tapao, Vietnam. Dr. Kwedar retired in Florida Air Force National Guard. He served Northwestern Sept. 1993 to Naples, Fla. in the medical corps, USAF Reserve, in University. He then California from 1980 to 1982, and then served on active duty from 1966 through Andrew D. Bunta, ’67 MD, ’74 GME, switched to the USAR in order to work at 1968, during the Vietnam War, and was completed a classic rotating internship and Letterman Army Hospital in San Francisco. stationed at RAF Chicksands Dispensary, was then drafted by the military with He helped with the orthopaedic training England, as the medical officer for the AF assignment to the USAF during the program by attending in the orthopaedic Security Service base. Vietnam War, as essentially all physicians clinic and performing surgery, primarily on After being discharged as a captain from had a military commitment—either before or low back pain patients. (More online.) the USAF, Dr. Pickard returned to the after residency training. As were most University of Miami Medical School for a physicians prior to completing their Robert delaFuente, ’64 MD, completed his residency in general surgery, later special- residency training, he was commissioned as internship at the U.S. Naval Hospital, St. izing in ear, nose and throat surgery. He a captain and functioned as a general Albans, N.Y., followed by a residency in began his practice of medicine and surgery medical officer, family physician, for most anesthesiology at the Naval Hospital in South Miami and Coral Gables in 1972. He of his tour of duty from 1968 to 1970. He Chelsea, Mass. Upon completion of that joined the Florida National Guard and was assigned to the Minot Air Force Base in training, he was sent to field basic training served a total of 22 years in active service, Minot, N.D.—the “land of ‘horizontal snow’

WINTER 2014-15 31 WARD ROUNDS® NEWS: PROGRESS NOTES

and frigid, Arctic cold, but extremely Tim Hunter, ’68 MD, ’69 GME, served in most of us were drafted. I spent my time pleasant and thoughtful people.” It was a the Navy from 1969 to 1971, including a acting as a base physician doing general large base with a population of 15,000 and tour of duty in Vietnam. As part of the medical practice in support of active included an SAC bomber wing, a fighter Navy Medical Corps, he served in the Field military and retired military persons in squadron and an ICBM group. (More online.) Medical Services School, Camp Pendleton, the area.” (More online.) California, in Sept. 1969, and the Marine Jon Scott Fantz, ’67 MD, served in the USNR Corps Air Station El Toro, Santa Ana, Calif., Louis H. Martone, ‘70 MD, served as a from 1968 to 1970 at Naval Submarine from Oct. 1969 to May 1970. He was then a general medical officer at MacDill AFB, Base, Norfolk, Va., and Naval Support general medical officer, First Marine Aircraft Tampa, Fla., from Aug. 1971 to Aug. 1973, Activity, Da Nang, Vietnam. Wing, Republic of Vietnam, from June 1970 after graduating and interning at Passavant to April 1971, and finally medical officer for Memorial Hospital. While at MacDill, he was Wynn Kearney, ’67 the Marine Officer’s Candidate School, from introduced to dermatology by the base MD, writes: “The May to Sept. 1971. (More online.) dermatologist. He was accepted for a Vietnam War was dermatology residency at University raging and there was F. Peter Rentz, ’68 MD, Hospitals of Cleveland, Case Western a physician draft in ’70 GME, served as a Reserve Medical School. He returned home effect when I was physician in the Navy to Pittsburgh to open a private practice in medical school. from 1969 to 1971. Dr. in 1976, where he still works full time. I believe most Rentz writes: “In those Dr. Martone is looking forward to his 45th members of our class were drafted... The days we had the Berry class reunion in April. Berry Plan was a program that gave a Plan, which was a deferment until specialty training was lottery that deter- J.D. Bartleson, ’71 MD, sends greetings from completed for certain specialties. I was mined if a physician could complete residency Rochester, Minn., where he has been seeing deferred until I completed my orthopaedic before entering service. I lost, making me a interesting neurology patients at the Mayo surgery residency at the Mayo Clinic in general medical officer with internship Clinic for 37 years. He writes: “I served as a 1972.” (More online.) training only. I elected to complete a course neurologist from July 1975 to July 1977 at in submarine and diving medicine, which Ft. Knox, Ky., as a major. It was peacetime. Michael Reinstein, ’67 MD, served in the cost me an extra six months but put me in Kentucky is very nice.” Army from 1969 to 1971, at Ft. Benning, some interesting assignments, first on a Georgia. He was assigned as a psychiatrist nuclear submarine, then with the diving Joseph “Joe” Haddock, ’72 MD, spent three but his biggest commitment was playing on Navy in Little Creek, Va. I was encouraged years in the Navy after medical school and the Army Hospital basketball team, which by the commanders to participate in diving an internship in medicine at the Medical included several N.B.A. draftees, before exercises as an additional officer, spending Center Hospital of Vermont/University of large crowds. Dr. Reinstein writes: “I quite a bit of my time under water. I grew to Vermont. He served as a general medical continue to practice psychiatry in the know and respect the men of the Special officer at Camp Lejeune, North Carolina. Uptown area of Chicago. My basketball Warfare Group. I call it my ‘veterinary One quarter of his time was spent as a playing days ended years ago.” period,’ providing primary care to about a battalion medical officer with 2nd Battalion, thousand divers of the Frogmen and Seal 6th Regiment, 2nd Marine Division. The Cary Andras, Jr., ’68 MD, writes: “After teams.” (More online.) other 75 percent of his time was spent as graduating in 1968, I did a straight surgery primary care physician in a small clinic with internship at Ohio State University with Dr. a PA and two corps women caring for the Robert Zollinger. Though controversial, I ’70s families of the enlisted. (More online.) have to say that I loved him like a father. He provided a great preparation for my active Robert Choplin, ’70 MD, ’71 GME, served in Arnold R. Eiser, ’74 MD, recently released duty time. Most will not be aware that Dr. the USAF from Aug. 1972 to Aug. 1974, “The Ethos of Medicine in Postmodern Zollinger was General Patton’s surgeon in where he was a general medical officer America: Philosophical, Cultural, and Social Europe and, I believe, in North Africa. As based in Blytheville, Ark. This base has Considerations,” published by Lexington most did then, I entered military service since closed. Dr. Choplin writes: “Since I had Books, Rowman & Littlefield, 2014. The through the Berry Plan. I was assigned to already graduated from medical school, it book, according to Zygmunt Bauman, the Navy after a couple of hiccups. I then did not influence my decision to go into Emeritus sociologist and philosopher, requested a couple of different duties, which medicine. Just to be clear, most of my University of Leeds, “…is not solely about were denied, and finally the Fleet Marine classmates and I served in the military. medicine but reaches much deeper into the Force (FMF).” (More online.) It was the time of the war in Vietnam and multiplying fissures in the tissue of human

32 MAGAZINE.NM.ORG Alicia Armstrong, ’81 MD, had a military ’90s scholarship for medical school, and ultimately spent 22 years in the Army, Joseph Marquez, ’99 MD (left), celebrated retiring at the rank of colonel in 2003. ten years as chief of the Department of After retirement she took a position at Urology at the Polyclinic, a 180-physician the National Institutes of Health. Currently, multispecialty group in Seattle. He formed Dr. Armstrong holds a faculty position as professor of OB/GYN at the Uniformed Services University of the Health Sciences, as well as clinical privileges at Walter Reed National Military Medical Center. She also coordinates the military unintended pregnancy task force. Previously, she togetherness in a society in which the served as the chair of OB/GYN at Walter public sphere is subsumed by advertising, Reed Army Medical Center, and prior marketing, entertainment, computerization, to that, vice chair, division director, electronic gossip, and other interests consultant to the Army Surgeon General devoid of ethical orientation and in the for Women’s Health, and associate the department soon after completing a result ‘morality is strictly privatized, residency program director. Before residency at the University of Minnesota, individualized, compartmentalized in her assignment to Walter Reed, she and has since added three partners. He is personalized space.’” (More online.) coordinated the OB/GYN clerkship at married to Dr. Sioban Keel, an academic the Uniformed Services University of hematologist at the University of Washing- Gary R. Ahnquist, ’76 MD, retired from the Health Sciences. (More online.) ton. He spends his time enjoying the Pacific obstetrics in June 2011 after 31 years and Northwest, playing jazz drums with 6,311 babies delivered. He now practices only Theresa Yuschok, ’85 MD, a psychiatrist Sometimes Marc—a group of Polyclinic gynecology. Dr. Ahnquist recently stepped and director at the Durham Veteran Affairs physicians—and making annual pilgrimages down as chief of staff at Ephraim McDowell Medical Center, graduated as an academic to Vancouver, B.C., to visit his good friend Regional Medical Center and is enjoying his associate of the Psychoanalytic Institute Jordan Moskoff, ’99 MD (right), as he shoots first grandchild, who was born in August. of the Carolinas. Recently she visited with episodes for “Untold Stories of the ER.” Julie Gsell Harley, ’82, who retired as senior Britt Kolar, ’77 MD, entered Navy Officer pastor of First United Church of Oak Park, Candidate School and served on active duty Ill. Dr. Yuschok also has kept in touch with ’00s from July 1968 to Jan. 1972 as a lieutenant, Elaine Cheng O’Leary, ’81, ’83, ’85 MD, ’89 the last two years in the Middle East. Dr. Kolar GME, Robin Ropar Heller, ’81, and Joyce Angela Powell, ’00 writes: “I felt strongly about our mission, and Sauter-Zafar, ’82. She hopes to hear from MD, was the first equally strongly about the needs of the 150 other charter members of the Humanities woman in her family sailors and marines and families for whom Residential College. to join the military. I was responsible. During this time, I She has been an experienced a ‘calling’ to become a family Jamie E. Terry, ’89 MD, is a general surgeon active duty physician physician. Thanks to Northwestern, the GI at Westside Surgical Hospital in Houston. since 2006, following Bill, and my wife and family, I was able to She specializes in breast health, with graduation from answer that calling five years later as a practices that focus on breast cancer residency training in otolaryngology at the resident at the University of Wisconsin, education, prevention and treatment University of Pittsburgh Medical Center. She Department of Family Medicine and Practice.” options. In the mid-1990s, Dr. Terry was the completed Officer Indoctrination, holding the first African American woman, and just the position of division officer as a lieutenant, and third female, to graduate from the St. then took on the rank of lieutenant commander ’80s Joseph Medical Center’s general surgery in Sept. 2006, shortly after arrival at her first training program in Houston. She and her duty station, Naval Medical Center San Diego. Michael Omori, ’80 MD, completed a husband Nelson have twin boys. As the only general otolaryngologist for this master’s in medical informatics at busy group practice, she distinguished herself Northwestern in Dec. 2013. In June, he by ranking among the top 10 percent of participated in his second Northwestern military otolaryngologists for patient graduation, 33 years after his first. encounters. (More online.)

WINTER 2014-15 33 Daniel S. Kim, ’04 MD, has been in the that I liked most areas of medical practice Alanna Higgins Joyce, MD, ’12 GME, Reserves since Jan. 2006. He was on active equally, there was not a specialty that I and Timothy Joyce ’10 MBA, of Chicago, duty from June 2008 through Dec. 2011 at was drawn to enter, and I probably celebrated the birth of their son, Charles Scott AFB, Illinois, as a family medicine faculty would have a general or family practice. Dyar, on Dec. 29, 2013. physician in the 375th Medical Operations Most of my USAF military experience was Squadron. He was then deployed to Balad as a flight surgeon.” (More online.) Joshua Cohen, MD, ’11 GME, joined the Air Base, Iraq, as a hospitalist from July 2009 staff at the Texas Heart Institute (THI) to Jan. 2010 in the 332nd Expeditionary Mark D’Agostino, in Houston as a cardiovascular anesthesi- Medical Operations Squadron. Currently, he MD, ’91, ’94 GME, ologist in August. Dr. Cohen completed his works as a family physician in Juneau, Alaska. completed his anesthesiology residency at Northwestern otolaryngology/head Memorial Hospital in 2011 and a fellowship and neck surgery in cardiovascular anesthesiology at the ’10s residency and then Texas Heart Institute in 2012. He worked in went on active duty private practice for a year before rejoining Jon Van Roo, ’10 MD, with the USAF, the staff at THI. joined the Wisconsin stationed at Andrews AFB in Washington, Air National Guard in D.C., from 1994 to 1997. While at Andrews, Oct. 1989 during his he provided otolaryngologist/head and neck PT senior year in high surgeon support to the crew of Air Force school. He went to One, the Pentagon, White House support Jeremy Campbell, ’14 basic training from staff, a large retired military community, and DPT, served as lance July through Aug. numerous other military agencies in the D.C. corporal, heavy 1990 at Lackland AFB, Texas, and then area, including the NSA and members of the machine gunner, with trained as a crew chief (aircraft mechanic) at various military bands. (More online.) 2nd Battalion, 1st Sheppard AFB, Texas. He finished his initial Marine Division, from training at Davis Monthan AFB, Arizona, Paul S. Brown Jr., MD, 2004 to 2007. He working on A-10s. Then he returned to ’93 GME, completed writes: “Following a Madison, Wis., where he continued to work his general surgery combat mission to Iraq, I was severely injured as an aircraft mechanic with the Air National residency at North- in a Humvee rollover accident in which I Guard through college. He had brief deploy- western, a research fractured my pelvis among other injuries. The ments to Denmark and Hawaii before fellowship at NIH, and hospitalizations and rehabs following this eventually graduating in 1996 from UW- then a thoracic traumatic event have shaped who I am today, Madison with a degree in engineering surgical fellowship at and have certainly impacted my decision to mechanics and astronautics. He worked as the University of Pennsylvania. Dr. Brown become a DPT. I am currently living in Chicago an aerospace engineer at Orbital Technolo- was influenced to join the Army Reserves and preparing for my board exam.” gies Corporation and deployed briefly to Medical Corps shortly after he finished at Kuwait in 1997. (More online.) Northwestern by Colonel Paul Meyer, MD, who was a professor of orthopaedic surgery DDS Sebastian Lara, ’12 MD, is currently in the at Northwestern Memorial Hospital, as well U.S. Navy as a lieutenant. He is also as by many other surgical faculty who had Charles J. Masered- currently a third-year resident in pediatrics served in the Armed Forces. Dr. Brown is a jian, Jr., ’66 DDS, of at Walter Reed National Military Medical colonel and just completed 21 years of Burbank, Calif., has Center in Bethesda, Md. service, during which he was deployed started to plan for twice to the Middle East. He currently the 50-year reunion, performs his Army Reserve duties at Ft. as class representa- GME Benning, Georgia. (More online.) tive for the Northwestern James L. Bryant II, MD, ’70, ’73 GME, writes: Michael Ault, MD, ’96 GME, an associate University Dental School Class of 1966. “My military experience definitely professor in the Department of Anesthesiol- The reunion will be held in Chicago on influenced my professional career path. ogy at Feinberg, was interviewed by “Good April 22 and 23, 2016. For more informa- After graduation in 1963 from the West Morning America” about Joan Rivers. http:// tion, please email Dr. Maseredjian at Virginia University School of Medicine, I abcnews.go.com/GMA/video/joan-rivers- [email protected] or call his cell entered the Air Force. At that time I felt family-remains-hopeful-recover-25210975 (818) 822-3172.

34 NORTHWESTERN MEDICINE MAGAZINE Progress Notes Awards and Honors

’70s

Elliott L. Cohen, ’72 MD, senior vice and innovation in founder and director of Cleveland Clinic’s president and regional medical director of undergraduate Minority Men’s Health Center, established in TeamHealth West, joined the Cedar Hill, instruction. Dr. 2003. He has served on the Ohio Commis- Texas location of First Choice Emergency Barratt says her sion on Minority Health since 2007. Room as medical director. personal mission is “nurturing learners to Bertrand C. Liang, ’88 Richard Lewis, ’78 MD, was inaugurated excellence in MD, PhD, MBA, is the president of the American Society of pediatric care through founder and CEO of Cataract and Refractive Surgeons in April. role modeling and relationship.” The review Pfenex Inc., a He will serve a one-year term. Dr. Lewis panels for the award consider a range of biotechnology was also appointed to the scientific activities and criteria in their evaluations of company in San advisory board at Aerie Pharmaceuticals. a candidate’s teaching performance, Diego, which com- including classroom expertise, curricula pleted an IPO and Ora Pescovitz, ’79 MD, former CEO of the quality, innovative course development and began trading on the NYSE–M (PFNX) in July. University of Michigan Health System, student learning outcomes. He was appointed to be the chair of the joined Eli Lilly & Co., in Indianapolis, as BioDefense Policy Advisory Committee at senior vice president in October. Harinder Singh, ’85 PhD, director of the the Biotechnology Industry Organization, division of immunobiology and the Center providing the strategic leadership for for Systems Immunology at Cincinnati public-private partnerships with the ’80s Children’s Hospital Medical Center, was government to develop countermeasures appointed chair of the scientific advisory addressing biologic weapons both domesti- Benjamin Kanter, ’82 MD, ’85 GME, chief board at Lycera Corp., a biopharmaceutical cally and abroad. Dr. Liang recently wrote an medical information officer at Palomar company. op-ed in the San Diego Union Tribune titled Health, was appointed chief medical officer “Lack of preparedness to Ebola is symptom at Sotera Wireless, a medical device Ellis Arjmand, ’86 MD, ’96 PhD, professor of of larger disease” and authored two books: developer of vital signs monitoring. otolaryngology at the University of “The Pragmatic MBA for Scientific and Cincinnati College of Medicine, was ap- Technical Executives” and “Managing and Frederic D. Seifer, ’82 MD, a pulmonology pointed chief of otolaryngology at Texas Leading for Science Professionals (What I specialist, was appointed medical director of Children’s Hospital in Houston. Wish I’d Known while Moving Up the population health at St. Lawrence Health Management Ladder),” both published by System in Ogdensburg, N.Y. M. Wayne Saville, ’86 MD, executive director Academic Press/Elsevier. for medical affairs at Genoptix, was Charles Argoff, ’84 MD, professor of appointed vice president of clinical develop- neurology at Albany Medical College and ment at Tocagen Inc., a clinical stage ’90s director of the Comprehensive Pain Center biopharmaceutical company. at Albany Medical Center, was appointed to David W. Zaas, ’98 MD, was named the scientific advisory board at SCILEX Charles Modlin, ’87 president of Duke Raleigh Hospital. Pharmaceuticals, Inc. MD, a kidney transplant surgeon and Michelle S. Barratt, ’85 MD, ’87 MPH, ’88 urologist, was ’00s GME, professor of pediatrics at the Univer- reappointed by Ohio sity of Texas Health Science Center at Governor John Kasich Kellie L. Heckman, ’05 PhD, was named Houston, recently received the Regents’ to a two-year term on executive director of the Global Federation Outstanding Teaching Award recognizing the board of the Ohio of Animal Sanctuaries. her extraordinary classroom performance Commission on Minority Health. Dr. Modlin is

WINTER 2014-15 35 WARD ROUNDS® NEWS: ALUMNI PROFILE

Caring for Cancer Survivors ——

AFTER THE TREATMENT IS DONE

Carol A. Rosenberg, ’80 MD, has more than circumstances—meant a second course of treatment and potentially BY KEVIN W. three decades’ experience as an internist, a worse prognosis. Luckily, her brother Ben was a perfect match MCCULLOUGH clinical researcher and medical educator, but and donated his bone marrow for a transplant performed at Ann & it was an unexpected medical crisis within Robert H. Lurie Children’s Hospital of Chicago. Yali recovered fully her own family that profoundly changed the and has been cancer-free ever since, but that personal experience course of her career. gave Rosenberg a new perspective on the continuum of care for Dr. Rosenberg, now director of cancer survivors. preventive health initiatives at NorthShore “Dealing with the things that happened afterward, and putting University HealthSystem and clinical my daughter and my family in the best position to ‘carry on’ after a associate professor at the University of traumatic experience like that, I learned what the essential Chicago Pritzker School of Medicine, directs ingredients are to care for cancer survivors,” explains Rosenberg, NorthShore’s Living in the Future (LIFE) previously one of the principal investigators for the landmark cancer survivorship program, which she also Women’s Health Initiative, a study from the 1990s examining the founded. She credits her experience both as risks of hormone replacement therapy. a physician and parent of a cancer survivor Although not an oncologist, in 2006 she was tapped to for her passion and commitment to establish NorthShore’s cancer survivorship program. With initial advancing cancer survivorship care. funding from a Lance Armstrong Foundation community education grant, Rosenberg founded the LIFE program. It was the first of A NEW PERSPECTIVE its kind in the Chicago area, weaving together community-based Rosenberg and her husband, Gordon efforts to empower and support cancer survivors, with individual- Derman, MD, a plastic and reconstructive ized health care, self-management tools and clinical support after surgeon, are the proud parents of Ari (31), treatment completion. Ben (27), and Yael “Yali”(24) Derman. In “The LIFE program was a way to merge my clinical savvy, my 2000, their daughter Yali suffered a clinical research experience, and my personal life, being the mom recurrence of acute lymphocytic leukemia, a of a cancer survivor,” she says. “I think I was selected because the cancer of the blood and bone marrow. The institution needed somebody who was thoughtful, who had relapse—extremely uncommon in her experience from both ends of the stethoscope.”

36 MAGAZINE.NM.ORG MANAGING THE TRANSITION A FAMILY OF SURVIVORS For patients, the LIFE program focuses on cancer survivorship For Rosenberg’s daughter, art therapy was an as a distinct phase of health care, emphasizing the transition to essential part of recovery. She channeled that a “new normal.” passion into the creation of a line of designer “There are specific kinds of resources and medical attention handbags, sold through Sak’s Fifth Avenue, that are necessary to enhance the lives of cancer survivors,” with all proceeds going to support family Rosenberg says. To that end, she dedicates a fair amount of time services at Lurie Children’s. Yali went on to coaching other physicians on how to provide primary care to graduate from the University of Pennsylvania long-term survivors. with a degree in nursing and is now a At the core of the LIFE program is a tailored, risk-adapted pediatric oncology nurse at Lurie Children’s. consultation with an oncology nurse. Over the course of the Dr. Rosenberg credits her upbringing for meeting, a personalized survivorship care plan is developed, which her unique approach to medicine: she was includes a cancer treatment summary, guidelines for monitoring raised in an observant Jewish household in for recurrence, and the long-term clinical consequences of their the Rogers Park neighborhood of Chicago and treatment, as well as suggested resources, services and providers both her parents were Holocaust survivors. with expertise in cancer survivorship issues. “My parents were very, very dedicated to The care plan isn’t just a tool for the patient: the detailed the idea of medicine, the idea of healing, and information is given to the patient’s primary care provider (and the idea of rebirth of the next generation,” incorporated into their electronic medical record). Rosenberg explains Rosenberg, whose brother, Michael believes it is essential to educate physicians about the serious J. Rosenberg, ’77 MD, ‘79 GME, her nephew, health consequences of cancer treatment that can crop up years Jonathan Rosenberg, ‘11 MD, and her son, after the disease is “cured.” Ben Derman, ’13 MD, all graduated from the The plan is only the beginning of the LIFE program, however, medical school at Northwestern. “The things a series of free Survivorship 101 seminars address the common that I’ve done—whether it’s primary care concerns and unique needs of recent cancer survivors. Topics include practice, clinical research, or being a mom nutrition, exercise, sexual intimacy after treatment, and dealing with and grandmother—have been accomplish- the insurance and employment consequences of lengthy treatments. ments that were derived from looking at the sanctity of life, and wanting to make the world a healthier place.” Rosenberg is even philosophical about her own family’s struggle with cancer. “I’ll always think that perhaps the situation with my daughter happened to our family because we have the fortitude and the emotional and intellectual resources to make life better for other survivors based on our experiences.”

DRS. CAROL ROSENBERG AND GORDON DERMAN WITH THEIR CHILDREN (FROM LEFT: ARI, YALI AND BEN) HOLDING HANDBAGS DESIGNED BY YALI THAT HELPED FUND THE PLAYROOM AT THE NEW LURIE CHILDREN’S HOSPITAL.

WINTER 2014-15 37 WARD ROUNDS® NEWS: ALUMNI PROFILE

EA R LY A LU M N I

PROFILES IN CU LT U RAL DIVERSITY

ULYSSES GRANT DAILEY: CARLOS MONTEZUMA: AN AFRICAN AMERICAN AN AMERICAN INDIAN WHO SURGEON, HOSPITAL FOUNDER ADVOCATED FOR CHANGE

by ron sims, now retired, for galter by amber bemis health sciences’ “library notes”

Ulysses Grant Dailey overcame financial and racial obstacles to become an In 1889, the medical school at Northwestern internationally respected surgeon. But more than that, Dr. Dailey was a teacher University marked a historically important year of physicians who later became leaders and role models; an editor, reflecting his when its first Native American student, Carlos ideals and passion for medicine through the Journal of the National Medical Montezuma, graduated. Association; an administrator, founding a hospital which trained young physicians Given the many challenges he faced early in and treated patients regardless of race; and an ambassador of American medicine, his life, this proved to be quite an achievement. traveling around the globe to study and shape healthcare systems. Originally named Wassaja, Dr. Montezuma was born Born in 1885 in Donaldsonville, La., Ulysses Grant Dailey, 1906 MD, grew up a Yavapai Indian in central Arizona in 1865. At age in Ft. Worth, Texas, and Louisiana. Choosing a career as a pianist, he graduated five, he was kidnapped by a neighboring tribe and from the preparatory academy at Straight College (now Dillard University) in sold for $30 to an Italian-born photographer. Carlo New Orleans. While a student, Dailey became the office assistant for Ernest L. Gentile bought his freedom, gave him a new name, Stephens, MD, a physician and professor in the medical department of Fort taught him English and enrolled him in school. Worth University. Impressed by the young man, Dr. Stephens assigned him to Montezuma received a bachelor’s of science visit homebound typhoid patients to take temperatures and do similar tasks. in chemistry from the University of Illinois before After this experience, Dailey wanted to study medicine. completing medical school. Following graduation, He was accepted at Northwestern University Medical School and enrolled in he began working as a physician for the Bureau of fall 1902. Until he graduated in 1906, Dailey supported himself through a variety Indians at many reservations across the country. of jobs, including playing piano in taverns. He eventually returned to Chicago to open a Because of his race, Dr. Dailey was not allowed to spend two weeks at Mercy private practice. Hospital in Chicago doing obstetrics in the charity ward. In 1907, Provident Throughout his career, Dr. Montezuma was an Hospital appointed Dailey gynecologist in their dispensary. The major turning advocate for Native American rights, and became point came in 1908 when Daniel Hale Williams, 1883 MD, an early graduate of the poster child of a Native American assimilated Northwestern’s medical school who was the first black member of the American into the “white man’s” culture, something he College of Surgeons and who founded Provident Hospital, invited Dailey to be considered very important for his people. He his surgical assistant. Over the next four years, Dailey learned much about began a group called the Society of American surgical techniques. In 1910, he became an associate surgeon, and from 1912 to Indians, which was controlled by indigenous 1926, he was an attending surgeon. leaders. He also spent much of his career working In 1926, Dr. Dailey purchased two large houses in Chicago and had them to eliminate the Bureau of Indian Affairs, which he remodeled into the Dailey Hospital and Sanitarium. The Great Depression forced thought had a biased and unfair agenda. He gave the closing of the institution in 1932. influential speeches and wrote a newsletter called Dailey was an active member of the National Medical Association for 53 Wassaja on the cause. years. He served in several leadership roles, including president from 1915-1916. Montezuma spent much of his later life However, his primary activity was with the Journal of the National Medical reconnecting with his Native American heritage. Association for which he served over a 40-year period as an editorial board mem- In 1922, he developed tuberculosis and died a year ber, associate editor, and editor. The association honored him with its later at the Yavapai’s Fort McDonald Reservation in Distinguished Service Award. Arizona. He was buried in the tribal cemetery.

38 NORTHWESTERN MEDICINE MAGAZINE Nature (1965)—that was chosen by the Journal of NIH Research as a landmark a pioneer article 30 years later—demonstrating that more than 96% of adult bone formation who changed occurs only after previous resorptive processes. He also developed a technique the field to histologically demonstrate microcracks in human bone biopsies and experimentally of skeletal showed that estrogens reduce bone turnover. Dr. Frost also proposed that bone biology mass is directly tied to lean muscle mass and muscle force.

by anita chase Much of his research is in current use. He (information compiled from the perfected a series of measurements that led journal of musculoskeletal neu- to quantitative bone histomorphometry, a ron interact and the journal of tool still employed by laboratories world- bone and mineral research, 2004) wide to evaluate the effects of some new drugs. His basic theories for bone growth plate adaptation to mechanical loading form the basis for many mathematical and computational bioengineering models. Harold M. Frost, ’46 MD, was a pioneer in skeletal biology and research. Though he died in June 2004, his research continues to Above all, Dr. Frost had a passion for have a profound influence in areas as disparate as orthopaedics, teaching. He fostered numerous efforts to endocrinology, orthodontics, anthropology and bioengineering. His facilitate better communication among two-volume textbook, “The Utah Paradigm of Skeletal Physiology,” skeletal scientists by helping to form the is recommended reading for those involved in the research and American Society for Bone and Mineral teaching of skeletal and related problems. Dr. Frost published Research (ASBMR) In Vivo Working Group nearly 500 peer-reviewed articles and is one of the most cited and the Black Forest Workshops, as well as investigators in skeletal research. helping co-found the Sun Valley Hard Tissue Workshops in 1966. After completing his medical degree at Dartmouth and Northwest- ern, he served as an officer in the Naval Medical Corps, and then He received the American Medical Associa- completed his surgical internship at the University of Massachu- tion’s Hektoen Gold Medal in 1963, but setts in Worcester and residencies in orthopaedic surgery at much of the recognition for his work didn’t Buffalo General and Children’s hospitals in New York. After two come until later. Most notable were the years in private practice, he became an assistant professor of Special Senior Investigator Award from the orthopaedic surgery at Yale University School of Medicine in 1955. American Society of Biomechanics (1987), Dr. Frost moved to Henry Ford Hospital in Detroit to become the the Sun Valley Hard Tissue Workshop founder and director of the Orthopedic Research Laboratory in Remodeling in Bone (RIB) award (1991), 1957, and department chair from 1966 to 1972, as well as clinical Honorary Doctor of Science degree from research professor of surgery at the University of Michigan School Purdue University (1994), Honorary of Medicine from 1968 through 1972. It was during his tenure at Professor of Surgery at Guangdong Medical Henry Ford Hospital that Dr. Frost made numerous research College, Zhanjiang, China (1994), the advances that changed the study of bone biology. William F. Neuman Award from the ASBMR (2001), and the creation of the Harold M. Many of Frost’s discoveries supported his concept that the skeleton Frost Professorship at Henry Ford Hospital is primarily a mechanical organ. He concluded that osteoclasts and (1991). The ASBMR/Harold Frost Young osteoblasts worked together as coordinated remodeling teams, Investigator and the Harold Frost Asian which he named Basic Multicellular Units, or BMUs. In collaboration Pacific Bone Morphometry Awards (2004) with Robert Hattner and Bruce Epker, Dr. Frost published a piece in were named after him.

WINTER 2014-15 39 In Memoriam Upcoming Events

FEB APR

Paul G. Alberton, ’65 Stanley W. Lipinski, FEBRUARY 17, 2015 APRIL 2, 2015 MD, of Carlsbad, ’51 MD, of Lakeland, Epilepsy Lecture: Marketa Marvanova, 11th Annual Lewis Landsberg Research Day Calif., died August Fla., died October PharmD, PhD, CGP Northwestern Memorial Hospital, 27, 2014. 25, 2014. Robert H. Lurie Research Building, Feinberg Pavilion, 3rd floor Searle Seminar Room 251 E. Huron St., Chicago. Robert B. Bright, ’46 James R. Mattson, 320 E. Superior St., Chicago. For more information, call 312-503-1499. MD, of Bremerton, ’66 MD, ’68 GME, of For more information, call 847-908-5035. Wash., died August Allouez, Wis., died APRIL 10, 2015 28, 2014. September 16, 2014. FEBRUARY 25, 2015 Brain Tumor Institute Lecture: Robert L. Davis, ’48 Louis D. Myre, ’52 Surviving and Thriving: STEM Evanthia Galanis MD, of Poulsbo, MD, of Paducah, Ky., Women’s Center Northwestern Memorial Hospital, Wash., died Septem- died October 15, 2000 Sheridan Rd., Evanston. Feinberg Pavilion, Pritzker Auditorium ber 17, 2014. 2014. For more information, call 847-491-7360. 251 E. Huron St., Chicago. For more information, call 312-908-5035. Michael W. Denson, Wendell K. Nickell, MD, ’87 GME, of ’51 MD, of Salina, MAR APRIL 21, 2015 Chicago, died Kan., died October Lectures in Life Sciences: Joan Goverman September 10, 2014. 18, 2014. MARCH 5, 2015 “Mechanisms Leading to the Development Robert E. Heerens, Ingrid Reese, ’80 Lurie Cancer Center Tumor Cell Biology of Multiple Sclerosis” ’44 MD, of Rockford, BSPT, of St. Charles, Robert H. Lurie Medical Research Center, Robert H. Lurie Medical Research Center, Ill., died October 19, Ill., died October 13, Baldwin Auditorium Hughes Auditorium 2014. 2014. 303 E. Superior St., Chicago. 303 E. Superior St., Chicago. For more information, call 312-695-1304. For more information, call 312-503-1889. Donald A. Jessen, Hirsh Wachs, ’56 ’54 MD, of Phoenix, MD, ’58, ’60 GME, MARCH 11, 2015 died September 20, ’59 MS, ’60 PhD, of FCVRI Seminar Series: Jan K. Kitajewski, PhD MAY 2014. Pittsburgh, died July Robert H. Lurie Medical Research Center, 22, 2014. Kenneth O. Johnson, Baldwin Auditorium MAY 7, 2015 ’58 MD, of Ocono- Margaret C. Winston, 303 E. Superior St., Chicago. Alzheimer’s Day mowoc, Wis., died ’52 MD, ’52 GME, of For more information, call 312-503-2296. Northwestern Memorial Hospital, October 25, 2014. Madison, Wis., died Feinberg Pavilion, 3rd floor Conference September 12, 2014. MARCH 18, 2015 Center Philip N. Jones, MD, HIV Translational Research Seminar 251 E. Huron St., Chicago. ’53 GME, of Lake Jack L. Wright, ’42 Robert H. Lurie Medical Research Center, For more information, call 312-908-9023. Forest, Ill., died MD, of Hebron, Md., Searle Seminar Room September 30, 2014. died September 26, 303 E. Superior St., Chicago. 2014. Ernest F. Kreutzer, For more information, call 312-695-5090. MD, ’84 GME, of Columbus, Ohio, died MARCH 27, 2015 October 28, 2014. Bacteriology Journal Club: Claire Knoten McGaw Pavilion, Room 2-322 MORE EVENTS AT Charles J. Leiphart, 240 E. Huron St., Chicago. MAGAZINE.NM.ORG ’67 MD, ’68 GME, of For more information, call 312-503-4138. Muncie, Ind., died September 19, 2014.

40 MAGAZINE.NM.ORG New Ads Highlight Growing Health System

In January, Northwestern Medicine launched its first advertising campaign as an expanded health system. The campaign, Every Breakthrough Leads to You, builds on the success of the current NM Breakthroughs campaign and serves as an introduction to who we are and the value of this growing health system. The campaign will run through summer 2015 and incorporate a variety of components, including a televi- sion commercial that launched during National Football Conference playoff games and The Golden Globe Awards, print advertising, outdoor billboards, website and social media content. The TV commercial is voiced by Bonnie Hunt, who was once an oncology nurse at Northwestern Memorial Hospital.

“Quarterly Bulletin” of the Resident Wins Scholarship for Medical School Now Available Commitment to Underserved in PubMed Central Luis Rivera, MD, a first-year resident in Family and Commu- nity Medicine, was awarded a $25,000 scholarship from the First published in June 1899, the Quarterly Bulletin of National Medical Fellowships. The Dr. David Monash/John the Northwestern University Medical School presented Caldwell Scott Medical Student Scholarship Program medical history and original scientific articles not provides financial support to medical students and resi- published anywhere else. Because it offered insights into dents committed to underserved populations in Chicago. medical practice and advances, along with news specific Growing up on Chicago’s South Side, Dr. Rivera to Northwestern University’s medical school, there have witnessed the shortcomings of the healthcare system been many requests for articles over the years from when his father was diagnosed with Parkinson’s disease. researchers at Northwestern and other institutions, “This experience opened my eyes to the very real need despite the fact that the Quarterly Bulletin ceased for more doctors in my neighborhood,” he says. publishing in winter 1962. To support his family, Rivera worked for 11 years as an Now, thanks to a digitization project made possible electrician at various area hospitals before pursuing his by an Illinois State Library grant, anyone in the world dream of medical school. can access full-text articles of the Quarterly Bulletin “I was really interested in this particular residency MORE EVENTS AT online for free on PubMed Central (PMC) at www.ncbi. because it is an academic program based in the commu- MAGAZINE.NM.ORG nlm.nih.gov/pmc/journals/1207/ and link to them from nity, with faculty focused on addressing health PubMed/MEDLINE. disparities in urban underserved communities,” he says.

fb.me/feinbergschoolofmedicine twitter.com/nufeinbergmed flickr.com/feinbergschoolofmedicine MORE CONTENT ONLINE AT MAGAZINE.NM.ORG Northwestern University Nonprofit Organization U.S. Postage Office of Communications PAID Northwestern University Northwestern University Feinberg School of Medicine 420 East Superior Street, Rubloff 12th floor Chicago, Illinois 60611

Change Service Requested

BUILDBUILDBUILD THEIR THEIRTHEIR FUTURE FUTUREFUTURE OurOurOur medicalmedical medical BUILDstudents students students are are theare the thefuture future future of of medicine—they ofmedicine—they medicine—theyTHEIR will will willmake make make a differencea differencea differenceFUTURE in inthe in the thelives lives lives of oftheir of their their patients patients patients and and and communities communities communities and andand discoverdiscover new new medical medical breakthroughs. breakthroughs. discover newOur medical medical breakthroughs. students are the future of medicine—they will make a difference in the lives of their patients and communities and discover new medical breakthroughs. TheTheThe burdenburden burden of of medical medicalof medical student student student debt debt debt is is a aisnationwide nationwide a nationwide concern. concern. concern. At At Feinberg, At Feinberg, Feinberg, we we needwe need need your your your help help help to solveto to solve solve this this this problem problem problem by increasing byby increasingincreasing our our our scholarshipscholarshipscholarship endowment. endowment.The endowment. burden of You You medical You can can canhelp studenthelp help us us be debtus be the be the is thetop a top nationwide topchoice choice choice for forconcern. thefor the themost most Atmost gifted Feinberg, gifted gifted and and and wepromising promisingneed promising your students, help students, students, to solve regardless regardless regardlessthis problem of abilityof of by abilityability increasing to pay. toto pay.pay. our scholarship endowment. You can help us be the top choice for the most gifted and promising students, regardless of ability to pay. YourYourYour giftsgifts gifts to to endowed endowedto endowed scholarships—including scholarships—including scholarships—including reunion reunion reunion and and and annual annual annual gifts gifts gifts to tothe to the theMD MD MD Endowed Endowed Endowed Scholarship Scholarship Scholarship Fund Fund Fund and and and Class ClassClass Scholarships—directlyScholarships—directlyScholarships—directlyYour gifts tosupport support endowed support our our scholarships—including ourstudents students students and and and make make make our our reunion ourvision vision vision andfor for theirannualfor their their future giftsfuture future topossible. thepossible. possible. MD Endowed Scholarship Fund and Class Scholarships—directly support our students and make our vision for their future possible. GiveGiveGive onlineonline online atat wewill.northwestern.edu/feinberg.atwewill.northwestern.edu/feinberg. wewill.northwestern.edu/feinberg. VisitVisit feinberg.northwestern.edu/giving feinberg.northwestern.edu/givingGive online at wewill.northwestern.edu/feinberg. for morefor more information. information. Visit feinberg.northwestern.edu/givingVisit feinberg.northwestern.edu/giving for more information.for more information. Questions?Questions? Contact Contact Development Development & Alumni & Alumni Relations Relations at 312-503-8933. at 312-503-8933. Questions? ContactQuestions? Development Contact Development & Alumni Relations& Alumni Relationsat 312-503-8933. at 312-503-8933. BuildBuild the Networkthe Network at feinberg.alumni.northwestern.edu. at feinberg.alumni.northwestern.edu. Build the NetworkBuild at the feinberg.alumni.northwestern.edu. Network at feinberg.alumni.northwestern.edu.