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2011 Annual Report

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2011 Annual Report Rochester Center for Biomedical Ultrasound icrobu ng m bble c eeri ont gin ras en t a e ge su n is ts t t E s standin i ect g w ss IP ef av u io e f e W b e c S ld h s U a y F r h I S a ling wa M c p H ve w t a a s r o U e r c n g r g o R i n g e z o i n l F t a a g i s s t g a t i a a o A o l e m g n i m R i r a F y c n s p c i I c t o h n i s n y e n o i l n u o n i t n q t g h r e a m e e i a r r a r f d v a a - r p a h h e s d a u n c g b t c i u i c o u s u a l r t o u h l s u a r s u t g n i l o t c n i r i t s a c r s e o r e u r D t o n t c d n o a o a i t b a e r r c p s p c l i e t r s u a o c c o a u s n t i o c i t r a a t d i v i a a t c i o n e c f r o 2011Annual Report RCBU laboratories are advancing biomedical ultrasound across many topics in diagnostic imaging, ultrasound therapy, and fundamental acoustics. See inside for highlights of RCBU research in 2011. Rochester Center for Biomedical Ultrasound Director: Diane Dalecki, PhD Associate Director: Deborah J. Rubens, MD Executive Committee: Diane Dalecki, PhD, Vikram S. Dogra, MD, Morton W. Miller, PhD, Kevin J. Parker, PhD, and Deborah J. Rubens, MD Provost: Ralph W. Kuncl, MD, PhD Senior Vice President and Robert L. and Mary L. Sproull Dean of the Faculty of Arts, Sciences, and Engineering: Peter Lennie, PhD Dean of the School of Medicine and Dentistry: Mark B. Taubman, MD Dean of the Hajim School of Engineering and Applied Sciences: Robert L. Clark, PhD Editor and Designer: Maria Randazzo Rochester Center for Biomedical Ultrasound, University of Rochester 311 Goergen Hall, PO Box 270168, Rochester, New York 14627 Phone: (585) 275-9542 n Email: [email protected] Web site: www.urmc.rochester.edu/rcbu © University of Rochester, 2012 2011 RCBU Annual Report Rochester Center for Biomedical Ultrasound 2011 Annual Report Table of Contents 2011 Research Tissue Elasticity Conference Highlights RCBU Awards Innovation RCBU Member Education 3 This year’s annual report The Imaging Sciences summarizes progress from RCBU Ultrasound Department laboratories across diverse continued its growth in exam topics in biomedical ultrasound and patient volumes in 2011, imaging and therapy. This year performing examinations marked the tenth anniversary on 24,800 patients. The of the International Tissue unit continued to expand Elasticity Conference. Over its clinical coverage; adding the years this conference has more sonographer positions to grown to become the premier manage the increased demand. conference for researchers in The University of Rochester the field of elasticity imaging. Medical Center was represented The RCBU continues to advance by sonographers and physicians new elastography techniques and included within this in education nationally and internationally. As faculty report are highlights of innovations by RCBU faculty and for the American Institute of Radiologic Pathology students in areas such as sonoelastography, crawling in Washington DC, Dr. Rubens continued to teach waves, intravascular ultrasound elasticity imaging, and courses on spleen, testis, scrotum, portal Doppler, and radiation force imaging techniques. testicular Doppler. Drs. Bhatt, Dogra, Rubens, Strang, On a more reflective note, this year the RCBU and Voci also participated as faculty at the Radiological and the broader ultrasound community lost one of its Society of North America (RSNA), the American Institute most important pioneers, Wesley Nyborg. Wes was a of Ultrasound in Medicine (AIUM), the Society of Charter Member of the RCBU. His seminal theoretical Gastrointestinal Radiologists (SGR), and the Society of and experimental work forms the foundation of our Uroradiology (SUR) Annual Meetings. Internationally, understanding of the biological effects of ultrasound. Drs. Rubens, Bhatt, Dogra, and Strang lectured at The The RCBU continues to play a prominent role Society for European Uroradiology in Dubrovnik, Croatia, in clinical and technological advances in the use of and Drs. Rubens and Strang lectured at the Israeli Society ultrasound for diagnostic imaging and therapy. Nonlinear for Ultrasound in Diagnostic Medicine in Haifa, Israel. imaging techniques, sonoelastography, and ultrasound Dr. Rubens also lectured at Cambridge University in contrast agents all have foundations from innovations England, and Dr. Dogra in Egypt and Turkey. within RCBU laboratories. This year a new patent Dr. Rubens continued her research with the BME in ultrasound imaging was issued to RCBU member Department in collaboration with General Electric Robert C. Waag. Collaborative projects between and Rensselaer Polytechnical Institute on the NIH RCBU clinicians, engineers, and scientists continue to funded grant, 3D Prostate Cancer Imaging Based on advance novel diagnostic and therapeutic applications of “Crawling Wave” Excitation, to create and assess a ultrasound. novel 3D imaging scanner applied to prostate cancer. This annual report details research from RCBU Investigations with elastography have expanded from members on many topics in biomedical ultrasound, the prostate to evaluation of thyroid cancer, with Dr. including elasticity imaging techniques, ultrasound Jonathon Walsh of ENT, and to assessment of hepatic technologies for tissue engineering, intravascular steatosis and fibrosis with Dr. Christopher Barry from ultrasound, ultrasound therapies, acoustic cavitation, and the liver transplant program. Dr. Barry with co-authors bioeffects. The RCBU also provides a rich environment Parker, Hah, Rubens, Mills, Mooney, and Ryan, had for education and training in biomedical ultrasound. their landmark paper, Shear Wave Dispersion Measures Educational advances, as well as special awards and Liver Steatosis, accepted this year for publication in achievements by RCBU members and students, are Ultrasound in Medicine and Biology. The Ultrasound summarized within this annual report. We welcome your Division is also co-investigator with Duke University, in comments on any of the enclosed reports. assessing DVT in oncology patients. Dr. Charles Francis, URMC faculty and Dr. Gary Lyman, Duke University, are Principal Investigators on the study. Dr. Mark Frampton, from Pulmonary Medicine, is conducting a clinical trial using ultrasound of the brachial artery to assess pulmonary response to environmental toxins. Clinical parameters for this trial will be assessed by the URMC ultrasound division. 4 The Rochester Center for Biomedical Ultrasound (RCBU) was created at the University of Rochester to unite professionals in engineering, medical, and applied science communities at the University of Rochester, Rochester General Hospital, and the Rochester Institute of Technology. Since its founding in 1986, the RCBU has grown over the years to nearly 100 members, with several visiting scientists from locations around the country. The Center provides a unique collaborative environment where researchers can join together to investigate the use of very high frequency sound waves in medical diagnoses and therapy. The Center’s mission encompasses research, education, and innovation. Research Innovation • RCBU laboratories are advancing the use of • The RCBU maintains a long history of leadership ultrasound in diagnosis and discovering new and innovation in biomedical ultrasound. therapeutic applications of ultrasound in medicine and biology. • RCBU innovations have produced steady progress in new imaging modalities and therapeutic • The Center fosters collaborative research between applications of ultrasound. laboratories and investigators with expertise in engineering, clinical medicine, and the basic • RCBU members hold numerous patents in sciences. ultrasound and imaging. The UR is a leader in technology revenue income among all higher • The RCBU provides an ideal forum to exchange education institutions in the nation. information through formal Center meetings and monthly newsletters. About the University of Rochester • Interactions of RCBU members with industry, governmental organizations, and foundations The University of Rochester (www.rochester.edu) is encourage mutually beneficial research programs. one of the nation’s leading private research universities. Located in Rochester, New York, the University’s environment gives students exceptional Education opportunities for interdisciplinary study and close • RCBU laboratories provide a rich environment collaboration with faculty. Its College of Arts, Sciences, for graduate training in biomedical ultrasound. and Engineering is complemented by the Hajim School Students have access to state-of-the-art research of Engineering and Applied Sciences, the Eastman facilities to engage in leading-edge research in School of Music, Simon School of Business, Warner ultrasound. School of Education, Laboratory for Laser Energetics, • The UR offers graduate-level courses in and Schools of Medicine and Nursing. biomedical ultrasound and closely related fields. • RCBU laboratories offer opportunities for post- doctoral research in ultrasound and collaborations with other areas of biomedical imaging. • Throughout its history, the RCBU has offered short courses in specialized topics in ultrasound that attract national and international experts. 5 2011 RESEARCH Research laboratories of RCBU members are advancing the use of ultrasound for diagnosis and therapy. The pages that follow highlight research accomplishments in 2011. Selected publications and presentations of this year can be found on pages 27-29. Crawling wave sonoelastography of benign to be formed without using a focused aperture. and malignant thyroid nodules Briefly, this method uses multifrequency J.M. Walsh, Brady Mills, BS, Deborah Rubens, (< 2 kHz) shear wave propagation perpendicular MD, Kevin J.
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