SNOMED CT Codes for Gynaecological Neoplasms
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Uterine Sarcomas: a Review
ARTICLE IN PRESS YGYNO-973334; No. of pages: 9; 4C: 3, 6 Gynecologic Oncology xxx (2009) xxx–xxx Contents lists available at ScienceDirect Gynecologic Oncology journal homepage: www.elsevier.com/locate/ygyno Review Uterine sarcomas: A review Emanuela D'Angelo, Jaime Prat ⁎ Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Sant Antoni M. Claret, 167, 08025 Barcelona, Spain article info abstract Article history: Objective. Uterine sarcomas are rare tumors that account for 3% of uterine cancers. Their histopathologic Received 29 June 2009 classification was revised by the World Health Organization (WHO) in 2003. A new staging system has been Available online xxxx recently designed by the International Federation of Gynecology and Obstetrics (FIGO). Currently, there is no consensus on risk factors for adverse outcome. This review summarizes the available clinicopathological data Keywords: on uterine sarcomas classified by the WHO diagnostic criteria. Uterine sarcomas Methods. Medline was searched between 1976 and 2009 for all publications in English where the studied Leiomyosarcoma population included women diagnosed of uterine sarcomas. Endometrial stromal sarcoma fi Undifferentiated endometrial sarcoma Results. Since carcinosarcomas (malignant mixed mesodermal tumors or MMMT) are currently classi ed Adenosarcoma as metaplastic carcinomas, leiomyosarcomas remain the most common uterine sarcomas. Exclusion of Carcinosarcoma several histologic variants of leiomyoma, as well as “smooth muscle tumors of uncertain malignant potential,” frequently misdiagnosed as sarcomas, has made apparent that leiomyosarcomas are associated with poor prognosis even when seemingly confined to the uterus. Endometrial stromal sarcomas are indolent tumors associated with long-term survival. Undifferentiated endometrial sarcomas exhibiting nuclear pleomorphism behave more aggressively than tumors showing nuclear uniformity. -
Histological Tumour Type (Required)
Histological tumour type (Required) Reason/Evidentiary Support All ovarian epithelial malignancies and borderline tumours should be typed according to the WHO classification.1 There are 5 major subtypes of primary ovarian carcinoma, high‐grade serous, clear cell, endometrioid, mucinous and low‐ grade serous.2‐5 There are also other uncommon minor subtypes, those listed by the WHO including malignant Brenner tumour, seromucinous carcinoma and undifferentiated carcinoma.1 Carcinosarcoma is a mixed epithelial and mesenchymal malignancy but is included in the category of epithelial malignancies in this dataset since most are of epithelial origin and histogenesis.6 Although management of ovarian carcinoma is, at present, largely dependent on tumour stage and grade, accurate typing will almost certainly become more important in the future with the introduction of targeted therapies and specific treatments for different tumour types. This is in part because, although clinically often considered as one disease, there is an increasing realisation that the different morphological subtypes of ovarian carcinoma have a different pathogenesis, are associated with distinct molecular alterations and have a different natural history, response to traditional chemotherapy and prognosis.2‐5 Tumour typing may also be important in identifying or initiating testing for an underlying genetic predisposition; for example, high‐grade serous carcinoma may be associated with underlying BRCA1/2 mutation while endometrioid and clear cell carcinomas can occur in patients with Lynch syndrome.7 The most common ovarian carcinoma is high‐grade serous carcinoma (approximately 70%) followed by clear cell and endometrioid.8,9 Mucinous and low‐grade serous are less common. Approximately 90% of advanced stage ovarian carcinomas (stage III/IV) are high‐grade serous in type.8,9 Most primary tubal carcinomas are high‐grade serous or endometrioid and most primary peritoneal carcinomas are of high‐grade serous type. -
Mr Leiomyoma Vs Leiomyosarcoma
2 0 SCBT· MR 1 LEIOMYOMA VS LEIOMYOSARCOMA 5 Susan M. Ascher, MD Professor & Co-Director of Abdominal Imaging Georgetown University Hospital, Washington, DC T2-W MRI: Normal Uterus, Leiomyoma and Leiomyosarcoma NORMAL LEIOMYOMA LEIOMYOSARCOMA LEIOMYOMA or LEIOMYOSARCOMA LEIOMYOMA LEIOMYOSARCOMA LEIOMYOMA or LEIOMYOSARCOMA LEIOMYOMA LEIOMYOSARCOMA LEIOMYOMA or LEIOMYOSARCOMA LEIOMYOMA LEIOMYOSARCOMA DEGENERATED LEIOMYOMA vs LEIOMYOSARCOMA Distinguishing the two can be challenging Laparoscopic Power Morcellators • Hysterectomy • Myommectomy Prognosis is significantly worse in women who had leiomyosarcomas morcellated than women who underwent standard abdominal hysterectomy Park JY, et al. Gynecol Oncol 2011; 122:255-259. Perri T, et al. Int J Gyencol Cancer 2009; 19:257-260 DEGENERATED LEIOMYOMA vs LEIOMYOSARCOMA Distinguishing the two can be challenging 4/17/14: FDA safety warning on LPM for hysterectomy & myomectomy • Prev of unsuspected uterine sarcoma: 1 in 352 • Prev of unsuspected uterine LMS: 1 in 498 • Upstaging sarcoma 1 in 7000 Pritts et al (open source) 7/10 -11/14: FDA OB-GYN Devices Panel FDA: Quantitative Assessment of the Prevalence of Unsuspected Uterine Sarcoma in Women undergoing Treatment of Uterine Fibroids. Summary and Key Findings http://www.fda.gov/downloads/MedicalDevices/Safety/AlertsandNotices/UCM393589. 7.11.14: “Fate of Uterine Device Now in Hands of FDA: Panel's Recommendations Run From Outright Ban to 'Black Box' Warning to Limited Use” Ethicon voluntarily suspend sales and recalls devices worldwide 9.22.14: “Gynecologists Resist FDA Over Popular Surgical Tool: Doctors Continue to Use Morcellators Months After Regulator Warned They Can Spread Undetected Cancer” 11.24.2014: FDA Black Box Warning & IIE “Warning Prompts Shift in Surgeries on Women” A Yale University study found that 84% of gynecological surgeons at large U.S. -
A Rare Presentation of Benign Brenner Tumor of Ovary: a Case Report
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Periasamy S et al. Int J Reprod Contracept Obstet Gynecol. 2018 Jul;7(7):2971-2974 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20182920 Case Report A rare presentation of benign Brenner tumor of ovary: a case report Sumathi Periasamy1, Subha Sivagami Sengodan2*, Devipriya1, Anbarasi Pandian2 1Department of Surgery, 2Department of Obstetrics and Gynaecology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India Received: 17 April 2018 Accepted: 23 May 2018 *Correspondence: Dr. Subha Sivagami Sengodan, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Brenner tumors are rare ovarian tumors accounting for 2-3% of all ovarian neoplasms and about 2% of these tumors are borderline (proliferating) or malignant. These tumors are commonly seen in 4th-8th decades of life with a peak in late 40s and early 50s. Benign Brenner tumors are usually small, <2cm in diameter and often detected incidentally during surgery or on pathological examination. Authors report a case of a large, calcified benign Brenner tumor in a 55-year-old postmenopausal woman who presented with complaint of abdominal pain and mass in abdomen. Imaging revealed large complex solid cystic pelvic mass -peritoneal fibrosarcoma. She underwent laparotomy which revealed huge Brenner tumor weighing 9kg arising from left uterine cornual end extending up to epigastric region. -
Resistance to Immune Checkpoint Blockade in Uterine Leiomyosarcoma: What Can We Learn from Other Cancer Types?
cancers Review Resistance to Immune Checkpoint Blockade in Uterine Leiomyosarcoma: What Can We Learn from Other Cancer Types? Wout De Wispelaere 1 , Daniela Annibali 1,2 , Sandra Tuyaerts 1,3 , Diether Lambrechts 4,5 and Frédéric Amant 1,6,7,* 1 Department of Oncology, KU Leuven (University of Leuven) and Leuven Cancer Institute (LKI), 3000 Leuven, Belgium; [email protected] (W.D.W.); [email protected] (D.A.); [email protected] (S.T.) 2 Division of Oncogenomics, Antoni Van Leeuwenhoek—Netherlands Cancer Institute (AvL-NKI), 1066 CX Amsterdam, The Netherlands 3 Laboratory of Medical and Molecular Oncology (LMMO), Department of Medical Oncology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium 4 Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven (University of Leuven), 3000 Leuven, Belgium; [email protected] 5 VIB Center for Cancer Biology, Flemish Institute for Biotechnology (VIB), 3000 Leuven, Belgium 6 Centre for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek—Netherlands Cancer Institute, University Medical Center (UMC), 1066 CX Amsterdam, The Netherlands 7 Department of Obstetrics and Gynecology, University Hospitals Leuven (UZ Leuven), 3000 Leuven, Belgium * Correspondence: [email protected] Simple Summary: Immune checkpoint blockade (ICB) has emerged as a very promising therapeutic option for patients, demonstrating unprecedented, durable responses in several difficult-to-treat Citation: De Wispelaere, W.; cancers. Despite research indicating a strong potential for ICB in uterine leiomyosarcomas (uLMSs), a Annibali, D.; Tuyaerts, S.; Lambrechts, clinical trial assessing response to ICB monotherapy in uLMSs showed no clinical benefit. Resistance D.; Amant, F. Resistance to Immune to ICB has been studied extensively in a variety of tumor types, but the resistance mechanisms Checkpoint Blockade in Uterine explaining the lack of response to ICB in uLMSs remain largely unexplored. -
Soft Tissue Cytopathology: a Practical Approach Liron Pantanowitz, MD
4/1/2020 Soft Tissue Cytopathology: A Practical Approach Liron Pantanowitz, MD Department of Pathology University of Pittsburgh Medical Center [email protected] What does the clinician want to know? • Is the lesion of mesenchymal origin or not? • Is it begin or malignant? • If it is malignant: – Is it a small round cell tumor & if so what type? – Is this soft tissue neoplasm of low or high‐grade? Practical diagnostic categories used in soft tissue cytopathology 1 4/1/2020 Practical approach to interpret FNA of soft tissue lesions involves: 1. Predominant cell type present 2. Background pattern recognition Cell Type Stroma • Lipomatous • Myxoid • Spindle cells • Other • Giant cells • Round cells • Epithelioid • Pleomorphic Lipomatous Spindle cell Small round cell Fibrolipoma Leiomyosarcoma Ewing sarcoma Myxoid Epithelioid Pleomorphic Myxoid sarcoma Clear cell sarcoma Pleomorphic sarcoma 2 4/1/2020 CASE #1 • 45yr Man • Thigh mass (fatty) • CNB with TP (DQ stain) DQ Mag 20x ALT –Floret cells 3 4/1/2020 Adipocytic Lesions • Lipoma ‐ most common soft tissue neoplasm • Liposarcoma ‐ most common adult soft tissue sarcoma • Benign features: – Large, univacuolated adipocytes of uniform size – Small, bland nuclei without atypia • Malignant features: – Lipoblasts, pleomorphic giant cells or round cells – Vascular myxoid stroma • Pitfalls: Lipophages & pseudo‐lipoblasts • Fat easily destroyed (oil globules) & lost with preparation Lipoma & Variants . Angiolipoma (prominent vessels) . Myolipoma (smooth muscle) . Angiomyolipoma (vessels + smooth muscle) . Myelolipoma (hematopoietic elements) . Chondroid lipoma (chondromyxoid matrix) . Spindle cell lipoma (CD34+ spindle cells) . Pleomorphic lipoma . Intramuscular lipoma Lipoma 4 4/1/2020 Angiolipoma Myelolipoma Lipoblasts • Typically multivacuolated • Can be monovacuolated • Hyperchromatic nuclei • Irregular (scalloped) nuclei • Nucleoli not typically seen 5 4/1/2020 WD liposarcoma Layfield et al. -
Aderomyoma of the Common Bile Duct --Report of a Case
Yamanashl Med. J. 4 (2), 83"v87, 1989 Case Report AdeRomyoma of the Common Bile Duct --Report of a Case Yoshiro MATsuMoTe, Masatoshi MoGAKi, Hidehisa AoyAMA, Takayoshi SEKmAwA, Katsnhiko SuGAHARA, Koichi SuDAi), and Masayuki FuJiNo2) DePa,rt・ment of Surge7pu. i)DePartment of Pathology, 2)DePartment of lnte7"nal Medicine, YamanasJzi Medical Coglege, Tamaho, Nakakoma, Ya?nanashi 409-38, JaPan Abstract: Adenomyomas in the extrahepatic biie duc£ are extremely rare. In a 75-year- old male with acute cholangitis due to adenomyoma £erming a protruding lesion iR the terminal bile duct, pamacreatoduodenectomy was carried out, resulting complete cure, Key words: Adenomyoma of the common bile duct, Early bile dact cancer, Obstructive jaundice formed, aRd £rom the histologic examina- INTRODUCTION tion of the surgical specimen, adenomyoma Adenomyoma in the biliary ductal system of the common bile duct was confirmed. is most freguently fouRd in the gallbladder. Although beRign neoplasma o£ the bile The gallbiadder wall is more abuRdant in duct system are uncommon, the tumors are muscle fibers than is the wall o£ the bile clinically very important because they can duct. Adenomyoma in the gallbladder is cause obstructive jaundice4) and require knowlt to be closely re}ated to the forma- differentiation £rom eary cancer of the bile tion of gallstones. In other parts of the duct. biliary ductal system, kex4xeve]-, adeno- We report here the surgical results and myoma is very rarei)・2), although a few pathologic findings in a case of adeno- cases of a tumor arising from the papil}a myoma of the terminal bile duct. of Vater3) have beelt reported. -
BSOG-FOGSI Quiz Preliminary Round Conducted on 24Th April at API
BSOG-FOGSI quiz preliminary round conducted on 24th April at API Bhavana South Zone Yuva Fogsi 2016 Quiz – BSOG round Topic- Gynecological Oncology 24th April, 2016 (60 marks) Name: Institution: Dear participants, Welcome to the FOGSI Quiz 2016 Thirty questions are to be answered in 30 minutes. Circle the right answer. Scratching and overwriting will get a negative marking even if the final answer is right. Each correct answer gets 2 marks and a wrong one gets a negative marking of minus 1.The top 2 scorers will represent BSOG in South Zone Yuva FOGSI 2016 in Madurai on 22nd May 2016. The decision of the Quiz Master is final. Happy Quizzing!!! 1. With regards to the staging of endometrial cancer, pick the wrong answer a. Stage 1a Endometrial Adenocarcinoma is confined to the uterus and involves less than half of the myometrium b. Stage 4a Endometrial Adenocarcinoma invades bladder mucosa c. Stage 4b Endometrial Adenocarcinoma involves inguinal lymph nodes d. Stage 3c2 Endometrial Adenocarcinoma involves more than half of myometrium and pelvic lymph nodes Ans: Stage 3c1 is involvement of pelvic nodes, Stage 3c2 is involvement of paraaortic nodes 2. The average time between HPV infection and pre-cancer is a. 2-5 years b. 15-20 years c. 7-10 years d. 20-25 years Novak 3. What factor does not contribute to persistence and progression of HPV infection? a. Smoking b. Contraceptive use c. STDs d. Drinking alcohol Novak 4. On Colposcopy, Adenocarcinoma has the following features a. Mosaic pattern b. Punctate lesions c. Abnormal vasculature d. -
Morphological Study of Ovarian Tumors with Special Reference to Germ Cell Tumors
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 1 Ver. VI (Jan. 2015), PP 55-60 www.iosrjournals.org Morphological Study of Ovarian Tumors with Special Reference to Germ Cell Tumors Dr. Kakumanu Nageswara Rao M.D (Path)1 Dr. Muthe Koteswari M.D (Path)2 Dr. Chaganti Padmavathi Devi MD, DCP3 Dr. Garikapati Sailabala MD(Path) 4 Dr. Ramya Katta MBBS5 1,2 Assistant Professor, Department of Pathology,Guntur Medical College, Guntur, A.P, India 3,4 Professor Department of Pathology, Guntur Medical College, Guntur, A.P, India Junior Resident Department of Pathology, Guntur Medical College, Guntur, A.P, India Abstract: Introduction: The study includes the morphological and histological aspects of the common tumors and also rare and uncommon ovarian tumors, with clinical manifestation, morphological and histopathological appearances. Material and Methods: Statistical incidence of ovarian tumors from 2001 to 2004 was taken. Specimens were processed routinely and sections, from representative sites, stained with hematoxylin and eosin were studied. Special stains like PAS, Vangieson, Reticulin and Alcian blue were done in special cases. Results: A total number of 150 ovarian tumors received from 2001 to 2004 have been studied. Of them 88 are benign tumors, 3 are borderline tumors & 59 are malignant tumors. Out of 150 ovarian tumors 122 were surface epithelial tumors, 9 were sex cord stromal tumors, 16 were germ cell tumors and 3 were metastatic tumors. Discussion: Ovary is the third most common site of primary malignancy in female genital tract and accounts for 6% of all cancers in females. -
Please Bring Your ~Rotocol, but Do Not Bring Slides Or Microscopes to T He Meeting, CALIFORNIA TUMOR TISSUE REGISTRY
CALIFORNIA TUMOR TISSUE REGISTRY FIFTY- SEVENTH SEMI-ANNUAL SLIDE S~IINAR ON TIJMORS OF THE F~IALE GENITAL TRACT MODERATOR: RlCl!AlUJ C, KEMPSON, M, D, ASSOCIATE PROFESSOR OF PATHOLOGY & CO-DIRECTOR OF SURGICAL PATHOLOGY STANFORD UNIVERSITY MEDICAL CEllTER STANFOliD, CALIFORNIA CHAl~lAN : ALBERT HIRST, M, D, PROFESSOR OF PATHOLOGY LOMA LINDA UNIVERSITY MEDICAL CENTER L~.A LINDA, CALIPORNIA SUNDAY, APRIL 21, 1974 9 : 00 A. M. - 5:30 P,M, REGISTRATION: 7:30 A. M. PASADENA HILTON HOTEL PASADENA, CALIFORNIA Please bring your ~rotocol, but do not bring slides or microscopes to t he meeting, CALIFORNIA TUMOR TISSUE REGISTRY ~lELDON K, BULLOCK, M, D, (EXECUTIVE DIRECTOR) ROGER TERRY, ~1. Ii, (CO-EXECUTIVE DIRECTOR) ~Irs, June Kinsman Mrs. Coral Angus Miss G, Wilma Cline Mrs, Helen Yoshiyama ~fr s. Cheryl Konno Miss Peggy Higgins Mrs. Hataie Nakamura SPONSORS: l~BER PATHOLOGISTS AMERICAN CANCER SOCIETY, CALIFORNIA DIVISION CALIFORNIA MEDICAL ASSOCIATION LAC-USC MEDICAL CENlllR REGIONAL STUDY GRaJPS: LOS ANGELES SAN F~ICISCO CEt;TRAL VALLEY OAKLAND WEST LOS ANGELES SOUTH BAY SANTA EARBARA SAN DIEGO INLAND (SAN BERNARDINO) OHIO SEATTLE ORANGE STOCKTON ARGENTINA SACRJIMENTO ILLINOIS We acknowledge with thanks the voluntary help given by JOHN TRAGERMAN, M. D., PATHOLOGIST, LAC-USC MEDICAL CENlllR VIVIAN GILDENHORN, ASSOCIATE PATHOLOGIST, I~TERCOMMUNITY HOSPITAL ROBERT M. SILTON, M. D,, ASSISTANT PATHOLOGIST, CITY OF HOPE tiEDICAL CENTER JOHN N, O'DON~LL, H. D,, RESIDENT IN PATHOLOGY, LAC-USC MEDICAL CEN!ER JOHN R. CMIG, H. D., RESIDENT IN PATHOLOGY, LAC-USC MEDICAL CENTER CHAPLES GOLDSMITH, M, D. , RESIDENT IN PATHOLOGY, LAC-USC ~IEDICAL CEUTER HAROLD AMSBAUGH, MEDICAL STUDENT, LAC-USC MEDICAL GgNTER N~IE-: E, G. -
HIV-1: Cancer Evaluation 8/1/16
Report on Carcinogens Monograph on Human Immunodeficiency Virus Type 1 August 2016 Report on Carcinogens Monograph on Human Immunodeficiency Virus Type 1 August 1, 2016 Office of the Report on Carcinogens Division of the National Toxicology Program National Institute of Environmental Health Sciences U.S. Department of Health and Human Services This Page Intentionally Left Blank RoC Monograph on HIV-1: Cancer Evaluation 8/1/16 Foreword The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). Three agencies contribute resources to the program: NIEHS/NIH, the National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention (NIOSH/CDC), and the National Center for Toxicological Research of the Food and Drug Administration (NCTR/FDA). Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. The Report on Carcinogens (RoC) is prepared in response to Section 301 of the Public Health Service Act as amended. The RoC contains a list of identified substances (i) that either are known to be human carcinogens or are reasonably anticipated to be human carcinogens and (ii) to which a significant number of persons residing in the United States are exposed. The NTP, with assistance from other Federal health and regulatory agencies and nongovernmental institutions, prepares the report for the Secretary, Department of HHS. -
SJMCR-47474-475.Pdf
DOI: 10.21276/sjmcr.2016.4.7.5 Scholars Journal of Medical Case Reports ISSN 2347-6559 (Online) Sch J Med Case Rep 2016; 4(7):474-475 ISSN 2347-9507 (Print) ©Scholars Academic and Scientific Publishers (SAS Publishers) (An International Publisher for Academic and Scientific Resources) Vulval Papillary Hidradenoma Clinically Mimicking a Sebaceous Cyst- A Case Report Swagata Dowerah, Bandita Das Dept. of Pathology, Assam Medical College, Dibrugarh, Assam *Corresponding author Swagata Dowerah Abstract: Hidradenoma papilliferum is a rare benign adnexal tumor with apocrine differentiation seen in anogenital area of women. We present a 25 year old female presenting with an asymptomatic mass in the vulva. On examination, a single round nodule was seen in the vulva , firm and non-tender. A clinical diagnosis of Bartholin’s cyst was made. On gross examination, a brownish mass measuring 1.5 X 1.5 X 1.5cms was seen which was greyish white on cut section. H &E stained sections showed papillary and complex glandular structures lined by columnar cells with eosinophilic cytoplasm. A diagnosis of papillary hidradenoma was made. This case is presented due to its rarity and to emphasise that while evaluating vulval nodules, hidradenoma needs to be considered, as these lesions lack distinctive clinical characteristics. Keywords: hidradenoma, papilliferum, vulva, sebaceous cyst. INTRODUCTION Hidradenoma papilliferum is a rare benign adnexal tumor having apocrine differentiation ,which usually presents as an asymptomatic flesh-colored nodule in the anogenital area of women [1]. It is considered by some to be an analog of intraductal papilloma of the breast [2]. It probably derives from anogenital mammary-like glands, which often are found in or around the hidradenoma[2, 3].