PROGRAMME Hotels Map & Locations
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38th Annual Conference of the International Society for Clinical Biostatistics Vigo, Spain 9-13 July 2017 PROGRAMME Hotels Map & Locations Technical Secretariat: Orzán Congres Phone: +34 981 900 700 More Info: www.iscb2017.info Email: [email protected] Table of contents 05 Preamble 06 Committees 07 Programme Overview 09 Programme: Sunday 9 13 Programme: Monday 10 27 Programme: Tuesday 11 37 Programme: Wednesday 12 49 Programme: Thursday 13 57 Instructions for Presenting Authors 61 Sponsors 65 General Information 69 Social Programme 81 Overview of the Conference Venue th Annual Welcome to the ISCB38 conference 38 July 9 - 13, 2017, Vigo, Spain Conference The 38th Annual Conference of the ISCB, hosted by the city of Vigo, brings together two plenary talks, eight oral invited sessions, and a number of oral and poster contributed sessions (Monday- Wednesday). Following the tradition of previous ISCB conferences, the Scientific Programme is of the International completed with several pre-conference courses (Sunday) and mini-symposia (Thursday). This booklet collects the information related to all these scientific activities. Society for Clinical The informations corresponding to the plenary talks, the invited and contributed presentations, the courses and the mini-symposia are gathered up day-to-day. The talks of ISCB President’s Invited Speaker Stephen Senn and Keynote Speaker Francesca Dominici can be found in Monday’s and Biostatistics Wednesday’s sections, respectively. We thank very much Stephen and Francesca for their plenary talks, and all the member of the Scientific Programme Committee and the invited speakers and course providers for helping to devise an excellent scientific programme. We particularly thank Vigo, Spain 9-13 July 2017 Stephen Senn for accepting ISCB President’s invitation shortly before the conference dates, as soon as it was known that Anastasios Tsiatis would not be able to attend the ISCB38. The number of contributed presentations raises to 363. They are distributed into 190 oral and 173 poster contributed presentations. All of them were selected by a peer review procedure, and we are happy to recognize the relevance and high-quality of all of them. Thanks to all the contributed authors! Last but not least, we would like to express our deepest gratitude to the members of the Local Organising Committee for making the conference possible. Jacobo de Uña Álvarez Guadalupe Gómez Melis Chair of the Local Organising Committee Chair of the Scientific Programme Committee 4 5 Committees Programme Overview The International Society for Clinical Biostatistics (ISCB) is devoted to stimulate research into the principles and methodology used in the design and analysis of clinical research and to increase the From To Sunday 9 Monday 10 Tuesday 11 Wednesday 12 Thursday 13 relevance of statistical theory to the real world of clinical medicine. 08.00 08.30 Registration Registration Registration 08.30 09.00 Registration Registration ISCB Executive Committee 09.00 09.30 Welcome President Past-President, Newsletter Editor 09.30 10.00 ISCB President’s IS OC PC IS OC PC Invited Speaker: KyungMann Kim US David W. Warne Switzerland 10.00 10.30 Stephen Senn SY SD Vice-President Chris Weir UK 10.30 11.00 CS Coffee Break Coffee Break Coffee Break Vana Sypsa Greece Hein Putter The Netherlands Katherine Lee Australia 11.00 11.30 Coffee Break Keynote Speaker: Treasurer Nadine Binder Germany Francesca Dominici Zdenek Valenta Czech Republic Stanislav Katina Czech Republic 11.30 12.00 Coffee Break IS OC PC IS OC PC Thomas Jaki UK Secretary Tomasz Burzykowski Belgium 12.00 12.30 SY SD Geir Egil Eide Norway Toshiro Tango Japan ISCB Annual 12.30 13.00 CS General OC OC Meeting 13.00 13.30 Scientific Programme Committee Local Organising Committee 13.30 14.00 Lunch Break Lunch Break Lunch Break Lunch Break Chair of Scientific Programme Committee Chair 14.00 14.30 Lunch Break Guadalupe Gómez Melis Spain Jacobo de Uña Álvarez (SPC) University of Vigo, Spain 14.30 15.00 SD Chair of Local Organising Committee Secretary 15.00 15.30 CS IS OC PC SY Jacobo de Uña Álvarez Spain Juan Carlos Pardo Fernández University of Vigo, Spain 15.30 16.00 IS OC PC Carmen Armero Spain Treasurer SD Frank Bretz Switzerland Javier Roca Pardiñas University of Vigo, Spain 16.00 16.30 Coffee Break Coffee Break Carmen Cadarso Spain 16.30 17.00 Coffee Break M. Luz Calle Spain Public Relations María Xosé Rodríguez Álvarez (SPC) Basque Center Marie Davidian US for Applied Mathematics BCAM IKERBASQUE, Basque 17.00 17.30 CS IS OC PC SD María Durbán Reguera Spain Foundation for Science, Spain Excursions Ronald Geskus The Netherlands 17.30 18.00 IS OC PC Els Goetghebeur Belgium Public Relations 18.00 18.30 ISCB39 Presentation Jeanine Houwing Duistermaat UK Mar Rodríguez Girondo Leiden University Medical Rosa Lamarca Spain Center, The Netherlands 18.30 19.00 Ian McGowan US Ana Luisa Papoila Portugal Sponsoring Support 19.00 19.30 María Jesús Longa Sayáns University of Vigo, Spain David Price UK 19.30 20.00 Geraldine Rauch Germany Students’ Support Staff Gathering María Xosé Rodríguez Álvarez Spain M. Carmen Iglesias Pérez University of Vigo, Spain 20.00 Welcome Reception Conference Dinner Montse Rué Spain Martin Schumacher Germany Support Staff Armando Teixeira Pinto Australia Carla M. Moreira Institute of Public Health, University Lee-Jen Wei US of Porto, Portugal CS IS OC PC SY SD Pre-conference Invited Oral Contributed Poster Contributed Mini-Symposia Students’ Day Courses Sessions Sessions Sessions PhD Student Marta Cousido Rocha University of Vigo, Spain 6 7 SUNDAY 9 38th Annual Conference of the International Society for Clinical Biostatistics Vigo, Spain 9-13 July 2017 SUNDAY 9 Programme Overview Detailed Programme Full-day courses From To Sunday 9 10.00 - 18.00 h. CS2: Causal Questions and Principled Answers: a Guide Through the CS2 CS3 CS5 Landscape for Practising Statisticians Room: Sala Mar 2 Causal questions The analysis of Advances in and principled recurrent event adaptive clinical Bianca DeStavola, UCL Great Ormond Street Institute of Child Health, answers: a data in clinical trial design: 10.00 11.30 United Kingdom guide through trials Bayesian and Els Goetghebeur, Ghent University, Belgium the landscape frequentist Saskia Le Cessie, Leiden University Medical Center, The Netherlands for practising approaches Erica Moodie, McGill University, Quebec, Canada statisticians Ingeborg Waernbaum, Umea University, Sweden 11.30 12.00 Coffee Break 10.00 - 18.00 h. CS5: Advances in Adaptive Clinical Trial Design: Bayesian and CS2 CS3 CS5 Frequentist Approaches Room: Sala Terra 2 12.00 13.30 Continued Continued Continued Rajat Mukherjee, Cytel, USA 13.30 14.30 Lunch Break Pantelis Vlachos, Cytel, Switzerland CS1 CS2 CS4 CS5 Half-day courses Statistical Continued Age-Period- Continued 14.30 16.00 methods for Cohort 10.00 - 13.30 h. CS3: The Analysis of Recurrent Event Data in Clinical Trials Room: Sala Mar 4 microbiome modeling studies Mouna Akacha, Novartis Pharma AG, Switzerland Richard Cook, University of Waterloo, Canada 16.00 16.30 Coffee Break CS1 CS2 CS4 CS5 14.30 - 18.00 h. CS1: Statistical Methods for Microbiome Studies Room: Sala Mar 4 16.30 18.00 Continued Continued Continued Continued M. Luz Calle, University of Vic - Central University of Catalonia, Spain 19.30 Students’ Gathering at Estrella Galicia brewery (Praza de Compostela) 14.30 - 18.00 h. CS4: Age-Period-Cohort Modeling Room: Sala Terra 4 Jon Wakefield, University of Washington, Seattle, USA 19.30 h. Students’ Gathering Estrella Galicia brewery (Praza de Compostela) From To Side Meetings (on invitation only) 11.30 13.00 Officers pre-meeting. Room: Hotel Eurostars 13.00 18.15 ExCom meeting. Room: Hotel Eurostars 10 11 MONDAY 10 38th Annual Conference of the International Society for Clinical Biostatistics Vigo, Spain 9-13 July 2017 MONDAY 10 Programme Overview Detailed Programme 09.00 - 09.30 h. Welcome Room: Auditorio From To Monday 10 09.30 - 10.30 h. ISCB President’s Invited Speaker Room: Auditorio 09.00 09.30 Welcome Stephen Senn, Competence Centre for Methodology and Statistics, Luxembourg Institute of Health ISCB President’s Invited Speaker: Stephen Senn 09.30 10.30 Competence Centre for Methodology and Statistics, Luxembourg Institute of Health The Revenge of RA Fisher: Thoughts on Randomgate and its Wider Implications The Revenge of RA Fisher: Thoughts on Randomgate and its Wider Implications Chair: KyungMann Kim 10.30 11.00 Coffee Break 10.30 - 11.00 h. Coffee Break Room: Hall IS1 OC1 OC2 OC3 OC4 PC1 11.00 - 12.30 h. IS1: Statistical Methods for Precision Medicine Room: Auditorio Statistical Bayesian Longitudinal Machine Multitaste Clinical Organised by Marie Davidian, North Carolina State University, USA methods for methods data learning for survival trials 1 Chair: Annette Kopp-Schneider 11.00 12.30 precision in clinical analysis and clinical data analysis and medicine research biomaker analysis dynamic IS1-1 Kelley Kidwell, University of Michigan, USA 1 discovery prediction 1 SMART Clinical Trial Design for Tailored Treatment Guidelines IS1-2 Eric Laber, Carolina State University, USA OC5 OC6 OC7 OC8 OC9 Sample Size Considerations for Precision Medicine STRATOS 1 Bayesian Methods for Rare diseares Survival IS1-3 Erica Moodie, McGill University, Quebec, Canada methods handling and small analysis 1 12.30 13.30 Personalizing Immunosuppressant Regimes Following Transplantation in clinical missing data 1 populations research 2 11.00 - 12.30 h. OC1: Bayesian methods in clinical research 1 Room: Sala Mar 2 Chair: Jordan Elm 13.30 15.00 Lunch Break 11.00 - 11.18 h. OC1-1 Thomas Burnett IS2 OC10 OC11 OC12 OC13 PC2 Enhancing adaptive enrichment trials using short term endpoints Methods in Biostatistics Joint Statistical Causal Clinical 11.19 - 11.36 h. OC1-2 Katharina Hees research on for high modelling in methods for inference 15.00 16.30 trials 2 Sample size recalculation in clinical trials incorporating historical data research dimensional practice 1 systematic and 11.37 - 11.54 h.