Epilepsy After Stroke
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Status Epilepticus Clinical Pathway
JOHNS HOPKINS ALL CHILDREN’S HOSPITAL Status Epilepticus Clinical Pathway 1 Johns Hopkins All Children's Hospital Status Epilepticus Clinical Pathway Table of Contents 1. Rationale 2. Background 3. Diagnosis 4. Labs 5. Radiologic Studies 6. General Management 7. Status Epilepticus Pathway 8. Pharmacologic Management 9. Therapeutic Drug Monitoring 10. Inpatient Status Admission Criteria a. Admission Pathway 11. Outcome Measures 12. References Last updated: July 7, 2019 Owners: Danielle Hirsch, MD, Emergency Medicine; Jennifer Avallone, DO, Neurology This pathway is intended as a guide for physicians, physician assistants, nurse practitioners and other healthcare providers. It should be adapted to the care of specific patient based on the patient’s individualized circumstances and the practitioner’s professional judgment. 2 Johns Hopkins All Children's Hospital Status Epilepticus Clinical Pathway Rationale This clinical pathway was developed by a consensus group of JHACH neurologists/epileptologists, emergency physicians, advanced practice providers, hospitalists, intensivists, nurses, and pharmacists to standardize the management of children treated for status epilepticus. The following clinical issues are addressed: ● When to evaluate for status epilepticus ● When to consider admission for further evaluation and treatment of status epilepticus ● When to consult Neurology, Hospitalists, or Critical Care Team for further management of status epilepticus ● When to obtain further neuroimaging for status epilepticus ● What ongoing therapy patients should receive for status epilepticus Background: Status epilepticus (SE) is the most common neurological emergency in children1 and has the potential to cause substantial morbidity and mortality. Incidence among children ranges from 17 to 23 per 100,000 annually.2 Prevalence is highest in pediatric patients from zero to four years of age.3 Ng3 acknowledges the most current definition of SE as a continuous seizure lasting more than five minutes or two or more distinct seizures without regaining awareness in between. -
Cognitive Impairment: Causes, Diagnosis and Treatment
NEUROLOGY - LABORATORY AND CLINICAL RESEARCH DEVELOPMENTS COGNITIVE IMPAIRMENT: CAUSES, DIAGNOSIS AND TREATMENT No part of this digital document may be reproduced, stored in a retrieval system or transmitted in any form or by any means. The publisher has taken reasonable care in the preparation of this digital document, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein. This digital document is sold with the clear understanding that the publisher is not engaged in rendering legal, medical or any other professional services. NEUROLOGY – LABORATORY AND CLINICAL RESEARCH DEVELOPMENTS SERIES Intracranial Hypertension Stefan Mircea Iencean and Alexandru Vladimir Ciurea 2009 ISBN: 978-1-60741-862-7 (Hardcover Book) Intracranial Hypertension Stefan Mircea Iencean and Alexandru Vladimir Ciurea 2009 ISBN: 978-1-60876-549-2 (Online Book) Cerebral Blood Flow Regulation Nodar P. Mitagvaria and Haim (James) I. Bicher 2009 ISBN: 978-1-60692-163-0 Cerebral Ischemia in Young Adults: Pathogenic and Clinical Perspectives Alessandro Pezzini and Alessandro Padovani (Editors) 2009 ISBN: 978-1-60741-627-2 Dizziness: Vertigo, Disequilibrium and Lightheadedness Agnes Lindqvist and Gjord Nyman (Editors) 2009: ISBN 978-1-60741-847-4 Somatosensory Cortex: Roles, Interventions and Traumas Niels Johnsen and Rolf Agerskov (Editors) 2009. ISBN: 978-1-60741-876-4 Cognitive Impairment: Causes, Diagnosis and Treatment Melanie L. Landow (Editor) 2009. ISBN: 978-1-60876-205-7 NEUROLOGY - LABORATORY AND CLINICAL RESEARCH DEVELOPMENTS COGNITIVE IMPAIRMENT: CAUSES, DIAGNOSIS AND TREATMENT MELANIE L. -
Non-Epileptic Seizures a Short Guide for Patients and Families
Non-epileptic seizures a short guide for patients and families Department of Neurology Information for patients Royal Hallamshire Hospital What are non-epileptic seizures? In a seizure people lose control of their body, often causing shaking or other movements of arms and legs, blacking out, or both. Seizures can happen for different reasons. During epileptic seizures, the brain produces electrical impulses, which stop it from working normally. Non-epileptic seizures look a little like epileptic seizures, but are not caused by abnormal electrical activity in the brain. Non-epileptic seizures happen because of problems with handling thoughts, memories, emotions or sensations in the brain. Such problems are sometimes related to stress. However, they can also occur in people who seem calm and relaxed. Often people do not understand why they have developed non-epileptic seizures. Are non-epileptic seizures rare? For every 100,000 people, between 15 and 30 have non- epileptic seizures. Nearly half of all people brought in to hospital with suspected serious epilepsy turn out to have non- epileptic seizures instead. One of the reasons why you may not have heard of non- epileptic seizures is that there are several other names for the same problem. Non-epileptic seizures are also known as pseudoseizures, psychogenic, dissociative or functional seizures. Sometimes people who have non-epileptic seizures are told that they suffer from non-epileptic attack disorder (NEAD). How can I be sure that this is the right diagnosis? Non-epileptic seizures often look like epileptic seizures to friends, family members and even doctors. Like epilepsy, non- epileptic seizures can cause injuries and loss of control over bladder function. -
SOS – Save Our Shoulders: a Guide for Polio Survivors
1 • Save Our Shoulders: A Guide for Polio Survivors A Guide for Polio Survivors S.O.S. Save Our Shoulders: A Guide for Polio Survivors by Jennifer Kuehl, MPT Roberta Costello, MSN, RN Janet Wechsler, PT Funding for the production of this manual was made possible by: The National Institute for Disability and Rehabilitation Research Grant #H133A000101 and The U.S. Department of the Army Grant #DAMD17-00-1-0533 Investigators: Mary Klein, PhD Mary Ann Keenan, MD Alberto Esquenazi, MD Acknowledgements We gratefully acknowledge the contributions and input provided from all of those who participated in our research. The time and effort of our participants was instrumental in the creation of this manual. Jennifer Kuehl, MPT Moss Rehabilitation Research Institute, Philadelphia Roberta Costello, MSN, RN Moss Rehabilitation Research Institute, Philadelphia Janet Wechsler, PT Moss Rehabilitation Research Institute, Philadelphia Mary Klein, PhD Moss Rehabilitation Research Institute, Philadelphia Mary Ann Keenan, MD University of Pennsylvania, Philadelphia Alberto Esquenazi, MD MossRehab Hospital, Philadelphia Cover and manual design by Ron Kalstein, MEd Albert Einstein Medical Center, Philadelphia Table of Contents 1. Introduction . .5 2. General Information About the Shoulder . .6 3. Facts About Shoulder Problems . .8 4. Treatment Options . .13 5. About Exercise . .16 6. Stretching Exercises . .19 7. Cane Stretches . .22 8. Strengthening Exercises . .25 9. Tips to Avoid Shoulder Problems . .29 10. Conclusion . .31 11. Resources . .31 The information contained within this manual is for reference only and is not a substitute for professional medical advice. Before beginning any exercise program consult your physician. Save Our Shoulders: A Guide for Polio Survivors • 4 Introduction Many polio survivors report new symptoms as they age. -
An Atypical Presentation of Epilepsy; What a Headache! J Neurol Transl Neurosci 5(1): 1078
Central Journal of Neurology & Translational Neuroscience Bringing Excellence in Open Access Case Report Corresponding author Sarah Seyffert, Trinity School of Medicine, 505 Tadmore court Schaumburg, Illinois 60194, USA, Tel: 847-217-4262; An Atypical Presentation of Email: Submitted: 13 April 2017 Epilepsy; What a Headache! Accepted: 07 June 2017 Published: 09 June 2017 Sarah Seyffert* and Wade Kvatum ISSN: 2333-7087 Trinity School of Medicine, USA Copyright © 2017 Seyffert et al. Abstract OPEN ACCESS The relationship between headache and seizure is a poorly understood and controversial topic; however, the literature has recently suggested that the two conditions may be related. Keywords The interplay between these conditions seems to be even more complex in a group of • Epilepsy patients with epilepsy related headaches. It has been proposed that the association could • Headache be classified into preictal, ictal, postictal, or interictal headaches. Here we present a case • Ictal epileptic headache report of a 62 year old male who presented with a chief complaint of new onset severe headache and subsequently underwent multiple diagnostic testing modalities before he was finally diagnosed and treated for epilepsy, which lead to the resolution of his headache. We conclude with a short discussion of how to subcategorize seizure related headaches based on their temporal relationship and why they can pose such a difficult diagnostic challenge. ABBREVIATIONS afebrile with a normal CBC and CMP. On arrival to the hospital he underwent a non-contrast head CT scan; however, no evidence of EEG: Electroencephalogram; CBC: Complete Blood Count; acute intracranial abnormality was seen. Additionally, a lumbar CMP: Complete Metabolic Panel; CT scan: Computerized puncture was performed which was negative for xanthochromia Tomography Scan; CTA: Computed Tomographic Angiography; and showed a protein count of 27, glucose 230, and 2 white MRI: Magnetic Resonance Imaging blood cells. -
Fatigue After Stroke
SPECIAL REPORT Fatigue after stroke PJ Tyrrell Fatigue is a common symptom after stroke. It is not invariably related to stroke severity & DG Smithard† and can occur in the absence of depression. It is one of the most troublesome symptoms for †Author for correspondence many patients and yet nothing is known of its causation. There are no specific treatments. William Harvey Hospital, Richard Steven’s Ward, This article assesses the available literature in the context of what is known about fatigue Ashford, Kent, in other disorders. Post-stroke fatigue may be a manifestation of sickness behavior, TN24 0LZ, UK mediated through the central effects of the cytokine interleukin-1, perhaps via effects on Tel.: +44 123 361 6214 Fax: +44 123 361 6662 glutamate neurotransmission. Possible therapeutic strategies are discussed which might be [email protected] a logical basis from which to plan randomized control trials. Following stroke, approximately a third of common and disabling symptom of Parkinson’s patients die, a third recover and a third remain disease [7,8] and of systemic lupus [9]. More than significantly disabled. Even those who recover 90% of patients with poliomyelitis develop a physically may be left with significant emotional delayed syndrome of post-myelitis fatigue [10]. and psychologic dysfunction – including anxi- Fatigue is the most prevalent symptom of ety, readjustment reactions and depression. One patients with cancer who receive radiation, cyto- common but often overlooked symptom is toxic or other therapies [11], and it may persist fatigue. This may occur soon or late after stroke, for years after the cessation of treatment [12]. -
Seizure Triggers
SEIZURE TRIGGERS M A R I A R AQUEL LOPEZ. M.D M I A M I V H A DEFINITION OF SEIZURE VS. EPILEPSY • Epileptic seizure: Is a transient symptom of abnormal excessive electric activity of the brain. EPILEPSY • More than one epileptic seizure. TYPE OF SEIZURES ETIOLOGY • Epilepsy is a heterogeneous condition with varying etiologies including: 1. Genetic 2. Infectious 3. Trauma 4. Vascular 5. Neoplasm 6. Toxic exposures TRIGGERS FOR EPILEPTIC SEIZURES • What is a seizure trigger? It is a factor that can cause a seizure in a person who either has epilepsy or does not. • Factors that lead into a seizure are complex and it is not possible to determine the trigger in each patient. TRIGGERS A. Most common ones Stress Missing taking the medication THE MOST OFTEN REPORTED BY PATIENTS • Sleep deprivation and tiredness • Fever OTHER COMMON CAUSES . Infection . Fasting leading into hypoglycemia. Caffeine: particularly if it interrupts normal sleep patterns. Other medications like hormonal replacement, pain killers or antibiotics. OTHER TRIGGERS External precipitants • Alcohol consumption or withdrawal. *Specific triggers that are related to Reflex epilepsy Bathing Eating Reading OTHER TRIGGERS • Flashing light: especially with patients with idiopathic generalized seizure disorder STRESS . Stress is the most common patient –perceived seizure precipitant, studies of life events suggest that stressful experiences trigger seizures in certain individuals. Animals epilepsy models provide more convincing evidence that exposure to exogenous and endogenous stress mediators has been found to increase epileptic activity in the brain, especially after repeating exposure. SOLUTION ABOUT STRESS • Intervention of copying with stress STRESS MANAGEMENT • Include trying to get in a place of peace utilizing multiple techniques: • Regular exercise • Yoga and medication • Therapy or psychological support with a provider. -
A Rare Case of Immune Reconstitution Inflammatory Syndrome Development in an Immunocompromised Patient with Progressive Multifocal Leukoencephalopathy And
Hindawi Publishing Corporation Case Reports in Neurological Medicine Volume 2013, Article ID 460701, 5 pages http://dx.doi.org/10.1155/2013/460701 Case Report A Rare Case of Immune Reconstitution Inflammatory Syndrome Development in an Immunocompromised Patient with Progressive Multifocal Leukoencephalopathy and Multicentric Castleman’s Disease Mohankumar Kurukumbi,1 Sheldon Steiner,1,2 Shariff Dunlap,1 Sherita Chapman,3 Noha Solieman,1 and Annapurni Jayam-Trouth1 1 Department of Neurology, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USA 2 Department of Neurology, Howard University College of Medicine, Washington, DC 20060, USA 3 Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA Correspondence should be addressed to Mohankumar Kurukumbi; [email protected] Received 27 June 2013; Accepted 17 July 2013 AcademicEditors:T.K.Banerjee,J.L.Gonzalez-Guti´ errez,´ R. Hashimoto, J. C. Kattah, and Y. Wakabayashi Copyright © 2013 Mohankumar Kurukumbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Immune reconstitution inflammatory syndrome (IRIS) development in HIV with preexistent progressive multifocal leukoen- cephalopathy (PML) has been extensively studied. PML-IRIS typically manifests clinically as new or worsening neurologic symptoms in conjunction with enlarging CNS lesions and occurs in approximately 10–20 percent of HIV-infected patients with PML who begin HAART. Likewise, Multicentric Castleman’s Disease (MCD), a rare malignant lymphoproliferative disorder, has a strong and well-known association with HIV. Our case provides a rare instance of PML-IRIS in combination with MCD in an HIV-positive individual. -
Epilepsy Syndromes E9 (1)
EPILEPSY SYNDROMES E9 (1) Epilepsy Syndromes Last updated: September 9, 2021 CLASSIFICATION .......................................................................................................................................... 2 LOCALIZATION-RELATED (FOCAL) EPILEPSY SYNDROMES ........................................................................ 3 TEMPORAL LOBE EPILEPSY (TLE) ............................................................................................................... 3 Epidemiology ......................................................................................................................................... 3 Etiology, Pathology ................................................................................................................................ 3 Clinical Features ..................................................................................................................................... 7 Diagnosis ................................................................................................................................................ 8 Treatment ............................................................................................................................................. 15 EXTRATEMPORAL NEOCORTICAL EPILEPSY ............................................................................................... 16 Etiology ................................................................................................................................................ 16 -
Seizure, New Onset
CLINICAL PATHWAY NEW ONSET SEIZURE Inclusion Criteria ALGORITHM 1. CONCERN FOR POSSIBLE SEIZURE • Age 6 months to 21 years • First-time seizure Exclusion Criteria • Status epilepticus (refer to status epilepticus pathway) Concern Unsure for possible Yes seizure? Obtain history and screening Obtain history and screening neurologic exam neurologic exam Consider differential diagnoses: Evaluate for possible provoking factors: • Breath holding • Fever/illness • Stereotypies/tics • Acute traumatic brain injury (TBI) ! • Vasovagal/syncope/vertigo • Central nervous system (CNS) infection Urgent call • Reflux • Tumor to ‘OneCall’ for: • Electrolyte imbalance • Ingestion • Suspected infantile spasm • Non epileptic seizure • Intoxication • Medically complex children • Electrolyte imbalance Off pathway: Consider outpatient referral to Neurology Off pathway: Provoked? Yes Address provoking factors No Continue to new onset unprovoked seizure algorithm on p.2 NEED REAL TIME HELP? CALL US! Call ‘OneCall’ at 720-777-3999 or 719-305-3999 (Colorado Springs) Page 1 of 17 CLINICAL PATHWAY ALGORITHM 2. NEW ONSET UNPROVOKED SEIZURE Inclusion Criteria • Age 6 months to 21 years New onset unprovoked • First-time unprovoked seizure seizure • Newly recognized seizure or epilepsy syndrome Exclusion Criteria • Provoked seizure: any seizure as a symptom of fever/illness, acute traumatic brain injury (TBI), Has central nervous system (CNS) infection, tumor, patient returned ingestion, intoxication, or electrolyte imbalance Consult inpatient • to baseline within No -
Stroke: Learn the Warning Signs and Protect Yourself Strokes Are the Leading Cause of Major Disability in the U.S
stroke: learn the warning signs and protect yourself Strokes are the leading cause of major disability in the U.S. and the second leading cause of death worldwide. With all the emphasis placed on heart disease reaches us, they’ve already been to the hospital. The and cancer as the two leading causes of death in only thing left by then is active physical therapy.” America, people often forget what ranks as third. The answer is stroke, and it can have debilitating Dr. Ray says that is why he preaches religiously effects even if you survive. to patients about lowering blood pressure and cholesterol, healthy diet and regular exercise, and On average, someone has a stroke in the U.S. every keeping any pre-existing conditions in check through 45 seconds, which equals 700,000 strokes a year. regular checkups. He goes on to say that having a Of these, about 500,000 are first-time strokes. primary care physician is vital. Strokes are so pervasive that they are the leading cause of major disability in the “All adults should speak to their doctors U.S. and the second leading cause of death about diet and controlling their blood worldwide. pressure,” Dr. Ray says. “You want to actively prevent this before it happens.” A stroke occurs when blood flow to parts of the brain is restricted or impaired, There are two basic types of stroke. The first killing off brain cells. Those cells can never is ischemic stroke caused by blood clots or regenerate, which means the damage is other particles in the blood vessels leading permanent. -
Supplementary Table Term* Revised Term** Focal Seizure Without Impairment of a Subjective Sensory Or Psychic Experience As Part of Migraine Or Epilepsy
Supplementary table Term* Revised term** Focal seizure without impairment of A subjective sensory or psychic experience as part of migraine or epilepsy. In epilepsy it is a focal consciousness or awareness Aura seizure without loss of consciousness (a simple partial seizure). It may or may not be followed by involving subjective sensory or other seizure manifestations. psychic phenomena only Automatic behaviour associated with loss of awareness, such as lip smacking or hand wringing, Automatism Focal dyscognitive seizure occurring as part of a complex partial seizure. Convulsion (previously "grand Tonic-clonic seziure, convulsive Seizure with involuntary, irregular myoclonic, clonic or tonic–clonic movements of one or more mal") seizure limbs. Onset may be focal or primary generalised. Literally ‘already seen’, this refers to a false impression that a present experience is familiar. It is used to refer to something heard, experienced or seen. It can be the aura of a temporal lobe Déjà vu seizure, but also happens in other settings (normal experience, intoxication, migraine, psychiatric). Focal seizure (previously "partial, Focal seizure A seizure originating in a specific cortical location. May be due to a structural lesion. localization related") Literally a ‘blow’. Usually used for an epileptic seizure (but can refer to other paroxysmal events, Ictus such as migraine, transient neurological events and stroke). Similarly pre- and post-ictal are used may for the period before and after a seizure. Idiopathic Genetic In relation to epilepsy, this implies that there is an underlying genetic cause. Literally ‘never seen’, this refers to a false impression that a present experience is unfamiliar. It is Jamais vu used for something seen, heard or experienced.