C-Glycosylflavones from the Leaves of Iris Tectorum Maxim
Acta Pharmaceutica Sinica B 2012;2(6):598–601 Institute of Materia Medica, Chinese Academy of Medical Sciences Chinese Pharmaceutical Association Acta Pharmaceutica Sinica B www.elsevier.com/locate/apsb www.sciencedirect.com ORIGINAL ARTICLE C-glycosylflavones from the leaves of Iris tectorum Maxim. Yuhan Maa,b,c, Huan Lid, Binbin Lina,b, Guokai Wanga,b, Minjian Qina,b,n aDepartment of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China bState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China cR&D Department of Jiangsu Honghui Medical Com. Ltd., Nanjing 210009, China dDepartment of General Surgery, General Hospital of North China Petroleum Administration Bureau, Renqiu 062552, China Received 12 June 2012; revised 29 August 2012; accepted 25 September 2012 0 000 KEY WORDS Abstract AnewC-glycosylflavone, 5-hydroxyl-4 ,7-dimethoxyflavone-6-C-[O-(a-L-3 -acetylrhamno- 0 pyranosyl)-1-2-b-D-glucopyranoside] (1), along with five known C-glycosylflavones, 5-hydroxy-4 ,7- Iris tectorum; 000 - Iridaceae; dimethoxyflavone-6-C-[O-(a-L-2 -acetylrhamnopyranosyl)-1 2-b-D-glucopyranoside] (2), embinin (3), C-glycosylflavones; embigenin (4), swertisin (5) and swertiajaponin (6) were isolated from the leaves of Iris tectorum Maxim. Cytotoxic activities Their structures were elucidated on the basis of extensive NMR experiments and spectral methods and their cytotoxic activities against A549 (lung cancer) human cell lines were determined. & 2012 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved. nCorresponding author. Tel.: þ86 25 86185130; fax: þ86 25 85301528.
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