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consultant on call RESPIRATORY MEDICINE Feline Asthma and Bronchitis Philip Padrid,RN,DVM,Family Pet Animal Hospital,Chicago,Illinois,and Ohio State University & University of Chicago Profile GEOGRAPHIC DISTRIBUTION asthma,” results from a complex interplay None recognized. of activated T lymphocytes, antigen, anti- gen-processing cells, various cytokine pro- DEFINITION teins and chemical messengers, and activat- Chronic bronchitis and asthma are both SIGNALMENT Siamese and Siamese-related breeds appear ed eosinophils and other inflammatory cells chronic inflammatory diseases that occur in to be at risk. Cats of any age may develop in the bronchial mucosa. The inflammatory the lower airways (bronchi and bronchioles). chronic bronchial disease, although young results of these processes include excessive In practice, it is often difficult to distinguish and middle-aged cats (1 to 8 years) most mucus secretion, airway wall edema, and, in between the two disorders. Chronic bronchi- commonly have the disorder. Male and asthmatic patients, bronchoconstriction. tis is defined in part by the presence of a female cats appear to be equally at risk. Airway muscle hypertrophy and hyperplasia daily cough; asthma is defined in part by are more common in asthmatic than in acute bronchoconstriction that may resolve bronchitic airways. Basement membrane spontaneously or with treatment. CAUSES thickening is a feature of asthma in humans Bronchoconstriction may or may not cause Unknown. The causes of asthma and bron- but has not consistently been found in cats. cough in an individual cat (known as cough- chitis probably differ. The most common causes of asthma in humans include house variant asthma). Thus, cats with a daily SIGNS cough may have either disorder, while cats dust mites, feline “dander,” and cockroach- Cough, mucus production, wheeze, open- without cough may have asthma but do not es; chronic bronchitis is the result of ciga- mouth breathing, and exercise intolerance have chronic bronchitis. Both disorders may rette smoke in humans, although this directly resulting from the pathophysiologic result in wheeze and exercise intolerance. association has not been shown in cats. derangements described above. Finally, human asthma is a syndrome in RISK FACTORS which the causes may vary greatly, including HISTORY allergy, exercise, and cold air, in individual Unknown. In humans with asthma, there is Cough and increased respiratory rate and patients. For purposes of this discussion, a 50% chance of developing asthma if both effort are common to asthma and chronic asthma in cats refers to allergic asthma. parents are asthmatic. Living indoors or out- doors is not causally associated with devel- bronchitis. There is usually a gag/choke or swallow at the end of the cough, signifying GENETIC IMPLICATIONS opment of chronic bronchitis or asthma in excess mucus production. Asthmatic Several “asthma genes” have been implicat- cats. Cigarette smoke increases symptoms in patients may have symptom-free periods, ed in the pathophysiology of human asth- human patients with established disease; whereas a daily cough is the defining fea- ma, and this is also an active area of passive cigarette smoke has been linked to ture of bronchitis. research in veterinary medicine. The Siamese bronchial disease in children. No data con- breed seems to be overrepresented, sug- firm this phenomenon in cats, although gesting an inherited trait. common sense suggests that exposure to cigarette smoke is probably harmful. Diagnosis INCIDENCE/PREVALENCE There are no precise actuarial data. Chronic PATHOPHYSIOLOGY PHYSICAL EXAMINATION bronchial disease (both bronchitis and asth- Unknown. In humans, cigarette smoke caus- Physical examination may be unremarkable. ma) probably affects 0.75% to 1% of the es cough, airway wall thickening, and hyper- Most cats with chronic bronchitis or asthma feline population in general and may affect trophy of the mucus-secreting apparatus. have increased bronchovesicular lung 5% of the Siamese breed. Asthma is more complex and is better sounds heard diffusely. Wheeze may be thought of as a “syndrome” with many heard, especially during expiration. causes. The most common form, “allergic continues consultant on call ..................................................................................................................NAVC clinician’s brief.....october.2005.....37 consultant on call C ONTINUED Respiratory rate may be increased, and tis is peribronchial cuffing, often described Bronchoscopy is usually not necessary for there may be nasal flaring. Cyanosis occurs as doughnuts or tram lines (Figure 1). diagnosis. Pulmonary function testing is in severe cases. Other common causes of cough and used to determine airway hyperresponsive- increased respiratory effort include pneumo- ness in asthmatic persons. This technology is DIAGNOSIS/DIFFERENTIAL DIAGNOSIS nia, heart failure, cancer, and heartworm dis- now available to approximate airway reac- There are no clinical signs or laboratory ease. These disorders usually create radi- tivity in awake, nonrestrained cats (Buxco tests available in general practice that are ographic abnormalities that differ from the box, Buxco Electronics; Wilmington, NC). pathognomonic for asthma or bronchitis. We classic findings of hyperinflation and pursue diagnostic testing in cats with bronchial markings seen in chronic bronchi- Skin testing for the presence of antigen- cough, tachypnea, and/or wheeze to deter- tis or asthma. specific IgE has been proposed as a way to mine the presence of other common causes determine an underlying “cause” of allergic of these signs—for example, heart failure, Both bronchitic and asthmatic cats have asthma. However, the biological response of pneumonia, pulmonary cancer, respiratory excessive airway mucus. Nonseptic neu- mast cells in skin often differs from that of parasitism, and inhaled foreign bodies. trophils are the predominant cell type in mast cells in the airways to the same anti- bronchial fluid. Eosinophils may predomi- gen in the same cat. For this reason, the LABORATORY FINDINGS/IMAGING nate in bronchial fluid from asthmatic cats, author does not yet recommend this manner Asthmatic cats often present with a history although healthy cats also frequently harbor of testing. of sudden onset of labored breathing that is large numbers of eosinophils in the respira- quickly relieved with some combination of tory tract. POSTMORTEM FINDINGS oxygen, bronchodilators, and steroids. In • Bronchitic and asthmatic airway epitheli- some cases, the only sign is chronic or inter- We also measure pulse oximetry in cats um may thicken (hypertrophy), evolve to a mittent cough. Patients with chronic bron- breathing room air to determine the relative different structure (metaplasia), or simply chitis have a history of chronic daily cough degree of impaired oxygen exchange. In become damaged (erosion or ulceration). with gag/choke or swallow at the comple- general, a pulse oximeter reading of 95% or • Bronchitic and asthmatic goblet cells and tion of the cough, representing excessive above (PaO2 of approximately 80 mm Hg or submucosal glands may enlarge and pro- mucus secretion. above) is considered stable; a reading of duce excessive amounts of a particularly 90% or below (PaO2 of approximately 60 thick form of mucus. The most common radiographic change mm Hg or below) is considered extremely • Asthmatic bronchial smooth muscle will common to both feline asthma and bronchi- unstable. often spasm and may undergo hypertro- phy and/or hyperplasia. These changes are associated with cellular infiltration of the bronchial mucosa and sub- mucosa. This tissue may also become ede- matous. See Figures 2 and 3. Treatment INPATIENT OR OUTPATIENT Asthmatic and bronchitic patients may pres- ent in various stages of distress. The deci- sion to hospitalize these patients is made on a case-by-case basis. In addition to clinical criteria, patients with a pulse oximeter read- 1 ing of 95% or higher are often treated as outpatients; those with readings of 90% or This lateral thoracic radiograph demonstrates classic features of feline asthma, including hyperinflation and peribronchial infiltration (doughnuts and tram lines). MDI = metered-dose inhaler 38....october.2005.....NAVC clinician’s brief ....................................................................................................................consultant on call Prednisone is gradually tapered over a 2- week period to allow the inhaled medica- tion to achieve its full effect. Bronchodilators Albuterol is given by inhalation as needed in the same manner as steroids. Albuterol can be given every one-half hour for 4 to 6 2 3 hours if needed in a crisis. Oral drugs can be used for cats that cannot tolerate inhaled A cross section from the large airway of a cat This large airway from a cat with chronic bronchitis with asthma, demonstrating the classic findings of demonstrates goblet cell hypertrophy and a mucus albuterol. The pharmacokinetics of theo- smooth muscle hypertrophy, invagination of plug. Airway smooth muscle is normal and there is phylline are well described in the feline epithelium (bronchoconstriction), and luminal exu- no evidence of bronchoconstriction, thus distinguish- species; however, in the author’s experience, date. ing bronchitis from asthma. the response to terbutaline (0.1 mg/kg PO Q 12 H) is more consistent. Cats in status asth- below are frequently hospitalized and treat- and the medication fills the spacer. The