Pediatric Surgery and Medicine for Hostile Environments
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Biological and Histological Assessment of the Hepatoportoenterostomy Role in Biliary Atresia As a Stand-Alone Procedure Or As a Bridge Toward Liver Transplantation
medicina Article Biological and Histological Assessment of the Hepatoportoenterostomy Role in Biliary Atresia as a Stand-Alone Procedure or as a Bridge toward Liver Transplantation Raluca-Cristina Apostu 1, Vlad Fagarasan 1 , Catalin C. Ciuce 1, Radu Drasovean 1 , Dan Gheban 2, Radu Razvan Scurtu 1,*, Alina Grama 3, Ana Cristina Stefanescu 3, Constantin Ciuce 1 and Tudor Lucian Pop 3 1 Department of Surgery, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400000 Cluj-Napoca; First Surgical Clinic, Emergency County Hospital, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania; [email protected] or [email protected] (R.-C.A.); [email protected] (V.F.); [email protected] (C.C.C.); [email protected] (R.D.); [email protected] (C.C.) 2 Department of Pathology, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400000 Cluj-Napoca; 4 th Pediatric Clinic, Emergency Clinical Hospital for Children, 68 Motilor Street, 400000 Cluj-Napoca, Romania; [email protected] 3 Department of Pediatrics, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400000 Cluj-Napoca; 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania; [email protected] (A.G.); [email protected] (A.C.S.); [email protected] (T.L.P.) * Correspondence: [email protected]; Tel.: +40-744-704-012 Abstract: Background and objectives: In patients with biliary atresia (BA), hepatoportoenterostomy (HPE) is still a valuable therapeutic tool for prolonged survival or a safer transition to liver transplantation. Citation: Apostu, R.-C.; Fagarasan, V.; The main focus today is towards efficient screening programs, a faster diagnostic, and prompt treatment. -
Is Pylorus Resecting Pancreaticoduodenectomy a Better Surgical Alternative Than Pylorus Preserving Pancreaticoduodenectomy Regarding Delayed Gastric Emptying?
Editorial Page 1 of 3 Is pylorus resecting pancreaticoduodenectomy a better surgical alternative than pylorus preserving pancreaticoduodenectomy regarding delayed gastric emptying? Shengliang He, Jin He Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Correspondence to: Jin He, MD, PhD, FACS. Department of Surgery, Johns Hopkins Hospital, 600 N. Wolfe Street, Blalock 665, Baltimore, MD 21287, USA. Email: [email protected]. Provenance: This is an invited Editorial commissioned by Section Editor Dr. Ang Li (Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China). Comment on: Hackert T, Probst P, Knebel P, et al. Pylorus Resection Does Not Reduce Delayed Gastric Emptying After Partial Pancreatoduodenectomy: A Blinded Randomized Controlled Trial (PROPP Study, DRKS00004191). Ann Surg 2018;267:1021-7. Received: 28 February 2018; Accepted: 19 March 2018; Published: 19 July 2018. doi: 10.21037/dmr.2018.07.04 View this article at: http://dx.doi.org/10.21037/dmr.2018.07.04 Pylorus preserving pancreaticoduodenectomy (PPPD) incidences (5). has been popularized as the surgical approach for patients As the currently largest, randomized controlled trial, with periampullary lesions by Traverso and Longmire PROPP study included 188 patients with statistical since 1978 (1). It was first hypothesized to reduce the superiority hypothesis (pylorus resection is associated occurrence of dumping, diarrhea, bile reflux gastritis and with less DGE than pylorus preservation). In the control improve overall nutritional status compared with classic group, duodenum was divided 2 cm distal to the pylorus. pancreaticoduodenectomy, also known as classic Whipple An antecolic end-to-side (ETS) duodenojejunostomy (CW). Based on the Cochrane database review in 2016, was performed 50 cm distal to the hepaticojejunostomy. -
Glossary for Narrative Writing
Periodontal Assessment and Treatment Planning Gingival description Color: o pink o erythematous o cyanotic o racial pigmentation o metallic pigmentation o uniformity Contour: o recession o clefts o enlarged papillae o cratered papillae o blunted papillae o highly rolled o bulbous o knife-edged o scalloped o stippled Consistency: o firm o edematous o hyperplastic o fibrotic Band of gingiva: o amount o quality o location o treatability Bleeding tendency: o sulcus base, lining o gingival margins Suppuration Sinus tract formation Pocket depths Pseudopockets Frena Pain Other pathology Dental Description Defective restorations: o overhangs o open contacts o poor contours Fractured cusps 1 ww.links2success.biz [email protected] 914-303-6464 Caries Deposits: o Type . plaque . calculus . stain . matera alba o Location . supragingival . subgingival o Severity . mild . moderate . severe Wear facets Percussion sensitivity Tooth vitality Attrition, erosion, abrasion Occlusal plane level Occlusion findings Furcations Mobility Fremitus Radiographic findings Film dates Crown:root ratio Amount of bone loss o horizontal; vertical o localized; generalized Root length and shape Overhangs Bulbous crowns Fenestrations Dehiscences Tooth resorption Retained root tips Impacted teeth Root proximities Tilted teeth Radiolucencies/opacities Etiologic factors Local: o plaque o calculus o overhangs 2 ww.links2success.biz [email protected] 914-303-6464 o orthodontic apparatus o open margins o open contacts o improper -
Morphologic Diversity in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: Catch Me If You Can! James S Lewis Jr
Modern Pathology (2017) 30, S44–S53 S44 © 2017 USCAP, Inc All rights reserved 0893-3952/17 $32.00 Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can! James S Lewis Jr Department of Pathology, Microbiology, and Immunology; Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN, USA As the human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma epidemic has developed in the past several decades, it has become clear that these tumors have a wide variety of morphologic tumor types and features. For the practicing pathologist, it is critical to have a working knowledge about these in order to make the correct diagnosis, not to confuse them with other lesions, and to counsel clinicians and patients on their significance (or lack of significance) for treatment and outcomes. In particular, there are a number of pitfalls and peculiarities regarding HPV-related tumors and their nodal metastases that can easily result in misclassification and confusion. This article will discuss the various morphologic types and features of HPV- related oropharyngeal carcinomas, specific differential diagnoses when challenging, and, if established, the clinical significance of each finding. Modern Pathology (2017) 30, S44–S53; doi:10.1038/modpathol.2016.152 It is now well-established that human papilloma- Among its many effects on clinical practice, the virus (HPV) is responsible for a large fraction of oropharyngeal HPV epidemic has put pathologists at oropharyngeal squamous cell carcinomas (SCC), the forefront of diagnosis and recognition of these particularly in the United States and Europe.1 Many unique tumors, which are much less clinically have termed the increase in HPV-related orophar- aggressive than conventional head and neck SCC, 7 yngeal SCC as an epidemic.2,3 There are numerous and which are beginning to be managed differently. -
Stem Cells and Artificial Substitutes Could Ease the Dependence on Blood Donations
OUTLOOK BLOOD DOING WITHOUT DONORS Stem cells and artificial substitutes could ease the dependence on blood donations. ANDREW BAKER BY ELIE DOLGIN S12 | NATURE | VOL 549 | 28 SEPTEMBER©2017 Ma c2017millan Publishers Li mited, part of Spri nger Nature. All ri ghts reserved. ©2017 Mac millan Publishers Li mited, part of Spri nger Nature. All ri ghts reserved. BLOOD OUTLOOK ach year, at about 13,000 collection centres worldwide, phlebotomists stick needles in the veins of healthy vol- unteers and amass in excess of 110 million donations of blood. The volume collected is enough to fill 20 Olympic- sized swimming pools — but it’s nowhere near to meeting the medical demand for whole blood or its components. To fill the gap, an enterprising group of stem-cell biologists and bio- Eengineers hopes to produce a safe, reliable and bottomless supply of on-demand blood substitutes in the laboratory. According to Robert Lanza, a pioneer of stem cell therapies and head IMAGES IWM VIA GETTY CHETWYN/ SGT. of global regenerative medicine at Astellas Pharma in Marlborough, Massachusetts, current technologies are not yet ready to compete with the real stuff. “We’re not going to put blood banks out of business any time soon,” he says. But in the near future, artificial blood products could be approved for use when transfusions are not otherwise an option, such as during combat or in people with a religious objection to receiving blood transfusions. And therapies that rely on reprogrammed stem cells to produce components of blood might also help transfusion centres to relieve shortages or to avoid donor-derived contamination. -
Middle Nasal Valve Collapse: a Way to Resolve
Journal of Otolaryngology-ENT Research Case Report Open Access Middle nasal valve collapse: a way to resolve Abstract Volume 10 Issue 3 - 2018 Middle nasal valve collapse is a partial or complete collapsing of soft structures of Dunja Milicic,1 Carolina Serodio2 nasal pyramid, due to negative intranasal pressures resulting in complete anterior nasal 1 obstruction of air-flow. Even though is relatively common, it is often misdiagnosed or Hospital da Luz Arrabida, Department of Otorhinolaryngology, Portugal neglected in diagnosis. There are too many suggestions of surgical resolution of the 2Hospital da Luz Póvoa de Varzim, Department of problem, giving an idea that all of them are actually only partially or insufficiently Otorhinolaryngology, Portugal resolving the problem. In this paper a possible solution of middle nasal vault collapse was presented. A Correspondence: Dunja Milicic, Hospital da Luz Arrábida, triangle cartilage grafting with respecting of anatomical and functional principles was Praceta de Henrique Moreira 150, 4400-346 Vila Nova de Gaia, Portugal, Tel +351-22 377-6800, suggested. An open rhinoplasty approach by its large exposure was, in our hands, the Email [email protected] election method for resolving the problem. Received: February 01, 2018 | Published: May 21, 2018 Keywords: nasal valve collapse, triangular cartilage, graft, open rhinoplasty Introduction the nostril (lateral alar crura) is usually annoying the patients, by its hardness and cosmetic deformity, even though some authors minimize Collapse -
Blood Product Replacement: Obstetric Hemorrhage
CMQCC OBSTETRIC HEMORRHAGE TOOLKIT Version 2.0 3/24/15 BLOOD PRODUCT REPLACEMENT: OBSTETRIC HEMORRHAGE Richard Lee, MD, Los Angeles County and University of Southern California Medical Center Laurence Shields, MD, Marian Regional Medical Center/Dignity Health Holli Mason, MD, Cedars-Sinai Medical Center Mark Rollins, MD, PhD, University of California, San Francisco Jed Gorlin, MD, Innovative Blood Resources/Memorial Blood Center, St. Paul, Minnesota Maurice Druzin, MD, Lucile Packard Children’s Hospital Stanford University Jennifer McNulty, MD, Long Beach Memorial Medical Center EXECUTIVE SUMMARY • Outcomes are improved with early and aggressive intervention. • Both emergency blood release and massive transfusion protocols should be in place. • In the setting of significant obstetric hemorrhage, resuscitation transfusion should be based on vital signs and blood loss and should not be delayed by waiting for laboratory results. • Calcium replacement will often be necessary with massive transfusion due to the citrate used for anticoagulation in blood products. • During massive transfusion resuscitation, the patient’s arterial blood gas, electrolytes, and core temperature should be monitored to guide clinical management and all transfused fluids should be warmed; direct warming of the patient should be initiated as needed to maintain euthermia and to avoid added coagulopathy. BACKGROUND AND LITERATURE REVIEW After the first several units of packed red blood cells (PRBCs) and in the face of continuing or worsening hemorrhage, aggressive transfusion therapy becomes critical. This report covers the experience with massive transfusion protocols. Lessons from military trauma units as well as civilian experience with motor vehicle accidents and massive obstetric hemorrhage have identified new principles such as earlier use of plasma (FFP/thawed plasma/plasma frozen within 24 hours/liquid plasma) and resuscitation transfusion while laboratory results are pending. -
Dorsal Approach Rhinoplasty Dorsal Approach Rhinoplasty
AIJOC 10.5005/jp-journals-10003-1105 ORIGINAL ARTICLE Dorsal Approach Rhinoplasty Dorsal Approach Rhinoplasty Kenneth R Dubeta Part I: Historical Milestones in Rhinoplasty ABSTRACT Direct dorsal excision of skin and subcutaneous tissue is employed in rhinoplasty cases characterized by thick rigid skin to achieve satisfactory esthetic results, in which attempted repair by more conventional means would most likely frustrate both surgeon and patient. This historical review reminds us of the lesson: ‘History repeats itself.’ Built on a foundation of reconstructive rhinoplasty, modern cosmetic and corrective rhinoplasty have seen the parallel development of both open and closed techniques as ‘new’ methods are introduced and reintroduced again. It is from the perspective of constant evolution in the art of rhinoplasty surgery that the author presents, in Part II, his unique ‘eagle wing’ chevron incision technique of dorsal approach rhinoplasty, to overcome the problems posed by the rigid skin nose. Keywords: Dorsal approach rhinoplasty, Eagle wing incision, Fig. 1: Ancient Greek ‘perikephalea’ to support the Rigid skin nose, External approach rhinoplasty, Historical straightened nose1 milestones. How to cite this article: Dubeta KR. Dorsal Approach and functions of the nose. Refinement of these techniques Rhinoplasty. Int J Otorhinolaryngol Clin 2013;5(1):1-23. seemingly had to await three antecedent developments; Source of support: Nil topical vasoconstriction; topical, systemic and local Conflict of interest: None declared anesthesia; and safe, reliable sources of illumination. The last half of the 20th century has seen the dissemination of INTRODUCTION two of the most important developments in the history of Throughout the ages, numerous techniques of altering, nasal surgery: correcting and more recently, improving the appearance and 1. -
Treatment of Equine Gastric Impaction by Gastrotomy R
EQUINE VETERINARY EDUCATION / AE / april 2011 169 Case Reporteve_165 169..173 Treatment of equine gastric impaction by gastrotomy R. A. Parker*, E. D. Barr† and P. M. Dixon Dick Vet Equine Hospital, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian; and †Bell Equine Veterinary Clinic, Mereworth, UK. Keywords: horse; colic; gastric impaction; gastrotomy Summary Edinburgh with a deep traumatic shoulder wound of 24 h duration. Examination showed a mildly contaminated, A 6-year-old Warmblood gelding was referred for treatment of 15 cm long wound over the cranial aspect of the left a traumatic shoulder wound and while hospitalised developed scapula that transected the brachiocephalicus muscle a large gastric impaction which was unresponsive to and extended to the jugular groove. The horse was sound medical management. Gastrotomy as a treatment for gastric at the walk and ultrasonography showed no abnormalities impactions is rarely attempted in adult horses due to the of the bicipital bursa. limited surgical access to the stomach. This report describes The wound was debrided and lavaged under standing the successful surgical treatment of the impaction by sedation and partially closed with 2 layers of 3 metric gastrotomy and management of the post operative polyglactin 910 (Vicryl)1 sutures in the musculature and complications encountered. simple interrupted polypropylene (Prolene)1 skin sutures, leaving some ventral wound drainage. Sodium benzyl Introduction penicillin/Crystapen)2 (6 g i.v. q. 8 h), gentamicin (Gentaject)3 (6.6 mg/kg bwt i.v. q. 24 h), flunixin 4 Gastric impactions are rare in horses but, when meglumine (Flunixin) (1.1 mg/kg bwt i.v. -
Complications of Splenectomy 2020; 4(2): 218-222 Received: 08-02-2020 Dr
International Journal of Surgery Science 2020; 4(2): 218-222 E-ISSN: 2616-3470 P-ISSN: 2616-3462 © Surgery Science Complications of splenectomy www.surgeryscience.com 2020; 4(2): 218-222 Received: 08-02-2020 Dr. Ketan Vagholkar Accepted: 10-03-2020 Dr. Ketan Vagholkar DOI: https://doi.org/10.33545/surgery.2020.v4.i2d.420 Professor, Department of Surgery. DY Patil University School of Abstract Medicine Navi Mumbai, Spleen is an important organ of the reticuloendothelial system. It plays a crucial role in the immunological Maharashtra, India system of the body. Understanding the consequences and diagnosis of hyposlenic and asplenic states is essential. Splenectomy is performed for a variety of indications ranging from haematological conditions to trauma. Complications of splenectomy include surgical as well as immunological. Overwhelming post splenectomy infection is one of the most dreaded complication with high mortality. The physiological basis of immunological function of the spleen, hyposplenism and complications of splenectomy are presented in this paper. Keywords: Post splenectomy, complications, hyposplenia, OPSI Introduction Spleen is a very important constituent organ of the reticuloendothelial system. The organ is crucial in regulating immune homeostasis through its ability to link innate and adoptive immunity in the process of protecting against infection. Hyposplenism is impairment of splenic function. It is usually acquired and caused by severe haematological and immunological disorders. Asplenia refers to the absence of the spleen which is rarely congenital but predominantly post-surgical (splenectomy). The most important complication of asplenic state is infectious complications [1]. These infections have high mortality. In addition to infectious complications, splenectomy can lead to a series of other complications. -
Figuration. One Might Be Inclined to Explain This
DR. E. HUGHES: CRANIOTABES OF THE FŒTUS AND INFANT. 1045 .experiments of Neuschlosz,40 who found that an emulsion of lecithin in water possesses a surface CRANIOTABES OF THE FŒTUS AND tension dependent on the amount of Ca present. INFANT. Too much or too little Ca had the same effect. In the therapeutic application of lime salts one also BY EDMUND HUGHES, M.R.C.S., L.R.C.P. LOND often notices opposite effects according to the amount used. IN a previous paper 1 I recorded some results of a To return for a moment t,o what Prof. Bayliss has clinical inquiry into this subject. The account then .called the " Clowes’s effect," it would seem that the given was composed under the combined disadvantages is view of the American author strongly supported of military service and paper shortage ; and this was by our experiments on the stereo-isomeric sugars. unfortunate, because the contentious nature of We have seen that pores are left between the oil- certain of the findings called for their rather full that ,drops, and it is obvious these pores, because presentment. I shall therefore make no apology they are subjected to the surface tension at the for re-stating these findings in somewhat more boundary, assume varying shapes. Now pores of a adequate form. could allow a con- definite shape sugars of definite Broadly, the position then reached was that the figuration-e.g., lævulose-to pass through, while recognised " craniotabes " arising during the first holding back sugars-e.g., glucose--of another con- few months of infancy is in many, and probably in be inclined figuration. -
Most Common Robotic Bariatric Procedures: Review and Technical Aspects Pablo A
Acquafresca et al. Ann Surg Innov Res (2015) 9:9 DOI 10.1186/s13022-015-0019-9 REVIEW Open Access Most common robotic bariatric procedures: review and technical aspects Pablo A. Acquafresca1, Mariano Palermo1*, Tomasz Rogula2, Guillermo E. Duza1 and Edgardo Serra1 Abstract Since its appear in the year 1997, when Drs. Cadiere and Himpens did the first robotic cholecystectomy in Brus- sels, not long after the first cholecystectomy, they performed the first robotic bariatric procedure. It is believed that robotically-assisted surgery’s most notable contributions are reflected in its ability to extend the benefits of minimally invasive surgery to procedures not routinely performed using minimal access techniques. We describe the 3 most common bariatric procedures done by robot. The main advantages of the robotic system applied to the gastric bypass appear to be better control of stoma size, avoidance of stapler costs, elimination of the potential for oro- pharyngeal and esophageal trauma, and a potential decrease in wound infection. While in the sleeve gastrectomy and adjustable gastric banding its utility is more debatable, giving a bigger advantage during surgery on patients with a very large BMI or revisional cases. Keywords: Bariatric surgery, Robotic surgery, Gastric by pass, Sleeve gastrectomy, Gastric band Background laparoscopy and robotic laparoscopy is now a controver- Since its appear in the year 1997, when Drs. Cadiere and sial topic that concerns patients and surgeons alike. Himpens did the first robotic cholecystectomy in Brussels To date, the robotic technique is reported to be at least [1], the da Vinci™ Robotic Surgical System from Intuitive as safe and effective as the conventional approach for sev- Surgical, Inc., Sunny Vale, California (Fig.