Skeletal System 2: Structure and Function of the Musculoskeletal System
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The Structure and Function of Breathing
CHAPTERCONTENTS The structure-function continuum 1 Multiple Influences: biomechanical, biochemical and psychological 1 The structure and Homeostasis and heterostasis 2 OBJECTIVE AND METHODS 4 function of breathing NORMAL BREATHING 5 Respiratory benefits 5 Leon Chaitow The upper airway 5 Dinah Bradley Thenose 5 The oropharynx 13 The larynx 13 Pathological states affecting the airways 13 Normal posture and other structural THE STRUCTURE-FUNCTION considerations 14 Further structural considerations 15 CONTINUUM Kapandji's model 16 Nowhere in the body is the axiom of structure Structural features of breathing 16 governing function more apparent than in its Lung volumes and capacities 19 relation to respiration. This is also a region in Fascla and resplrstory function 20 which prolonged modifications of function - Thoracic spine and ribs 21 Discs 22 such as the inappropriate breathing pattern dis- Structural features of the ribs 22 played during hyperventilation - inevitably intercostal musculature 23 induce structural changes, for example involving Structural features of the sternum 23 Posterior thorax 23 accessory breathing muscles as well as the tho- Palpation landmarks 23 racic articulations. Ultimately, the self-perpetuat- NEURAL REGULATION OF BREATHING 24 ing cycle of functional change creating structural Chemical control of breathing 25 modification leading to reinforced dysfunctional Voluntary control of breathing 25 tendencies can become complete, from The autonomic nervous system 26 whichever direction dysfunction arrives, for Sympathetic division 27 Parasympathetic division 27 example: structural adaptations can prevent NANC system 28 normal breathing function, and abnormal breath- THE MUSCLES OF RESPIRATION 30 ing function ensures continued structural adap- Additional soft tissue influences and tational stresses leading to decompensation. -
Mesenchymal Stem Cells in Combination with Hyaluronic Acid
www.nature.com/scientificreports OPEN Mesenchymal Stem Cells in Combination with Hyaluronic Acid for Articular Cartilage Defects Received: 1 August 2017 Lang Li1, Xin Duan1, Zhaoxin Fan2, Long Chen1,3, Fei Xing1, Zhao Xu4, Qiang Chen2,5 & Accepted: 19 April 2018 Zhou Xiang1 Published: xx xx xxxx Mesenchymal stem cells (MSCs) and hyaluronic acid (HA) have been found in previous studies to have great potential for medical use. This study aimed to investigate the therapeutic efects of bone marrow mesenchymal stem cells (BMSCs) combined with HA on articular cartilage repair in canines. Twenty-four healthy canines (48 knee-joints), male or female with weight ranging from 5 to 6 kg, were operated on to induce cartilage defect model and divided into 3 groups randomly which received diferent treatments: BMSCs plus HA (BMSCs-HA), HA alone, and saline. Twenty-eight weeks after treatment, all canines were sacrifced and analyzed by gross appearance, magnetic resonance imaging (MRI), hematoxylin-eosin (HE) staining, Masson staining, toluidine blue staining, type II collagen immunohistochemistry, gross grading scale and histological scores. MSCs plus HA regenerated more cartilage-like tissue than did HA alone or saline. According to the macroscopic evaluation and histological assessment score, treatment with MSCs plus HA also lead to signifcant improvement in cartilage defects compared to those in the other 2 treatment groups (P < 0.05). These fndings suggested that allogeneic BMSCs plus HA rather than HA alone was efective in promoting the formation of cartilage-like tissue for repairing cartilage defect in canines. Articular cartilage is composed of chondrocyte and extracellular matrix and has an important role in joint move- ment including lubrication, shock absorption and conduction. -
(AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: a Five-Year Follow-Up Prospective Cohort Study
life Communication Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: A Five-Year Follow-Up Prospective Cohort Study Filippo Migliorini 1 , Jörg Eschweiler 1, Nicola Maffulli 2,3,4,5,* , Hanno Schenker 1, Arne Driessen 1 , Björn Rath 1,6 and Markus Tingart 1 1 Department of Orthopedics and Trauma Surgery, University Clinic Aachen, RWTH Aachen University Clinic, 52064 Aachen, Germany; [email protected] (F.M.); [email protected] (J.E.); [email protected] (H.S.); [email protected] (A.D.); [email protected] (B.R.); [email protected] (M.T.) 2 School of Pharmacy and Bioengineering, Keele University School of Medicine, Staffordshire ST4 7QB, UK 3 Barts and the London School of Medicine and Dentistry, London E1 2AD, UK 4 Centre for Sports and Exercise Medicine, Queen Mary University of London, Mile End Hospital, London E1 4DG, UK 5 Department of Orthopedics, Klinikum Wels-Grieskirchen, A-4600 Wels, Austria 6 Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy * Correspondence: [email protected] Abstract: Introduction: Many procedures are available to manage cartilage defects of the talus, Citation: Migliorini, F.; Eschweiler, J.; including microfracturing (MFx) and Autologous Matrix Induced Chondrogenesis (AMIC). Whether Maffulli, N.; Schenker, H.; Driessen, AMIC or MFx are equivalent for borderline sized defects of the talar shoulder is unclear. Thus, the A.; Rath, B.; Tingart, M. Autologous present study compared the efficacy of primary isolated AMIC versus MFx for borderline sized Matrix Induced Chondrogenesis focal unipolar chondral defects of the talar shoulder at midterm follow-up. -
Series 1100TDM Tandem MEGALUG Mechanical Joint Restraint
Series 1100TDM Tandem MEGALUG® Mechanical Joint Restraint High Pressure Restraint for Ductile Iron Pipe Features and Applications: • For use on Ductile Iron Pipe 4 inch through 54 inch • High Pressure Restraint • Torque Limiting Twist-Off Nuts • Mechanical Joint follower gland incorporated into the restraint • MEGA-BOND® Coating System For more information on MEGA- BOND, visit our web site at www. ebaa.com • Minimum 2 to 1 Safety Factor Series 1112TDM restraining a mechanical joint fitting. • Constructed of A536 Ductile Iron Post Pressure Rating • EBAA-Seal™ Mechanical Nominal Pipe Shipping Assembly (PSI) Joint Gaskets are provided Size Weights* Deflection with all 1100TDM MEGALUG 4 21.6 3° 700 restraints. These are required 6 33.0 3° 700 to accommodate the pressure ratings and safety factors 8 40.0 3° 700 shown. 10 60.2 3° 700 12 75.0 3° 700 • New: High strength heavy hex 14 112.7 2° 700 machine bolts with T-nuts are 16 131.6 2° 700 provided to facilitate easier assembly due to the fittings 18 145.2 1½° 500 radius area prohibiting the use 20 166.6 1½° 500 longer T-bolts. 24 290.2 1½° 500 30 457.9 1° 500 • T-Nuts constructed of High 36 553.63 1° 500 Tensile Ductile Iron with Fluropolymer Coating. 42 1,074.8 1° 500 48 1,283.1 1° 500 For use on water or wastewater 54 1,445.32 ½° 400 pipelines subject to hydrostatic NOTE: For applications or pressures other than those shown please pressure and tested in accordance contact EBAA for assistance. -
Synovial Joints Permit Movements of the Skeleton
8 Joints Lecture Presentation by Lori Garrett © 2018 Pearson Education, Inc. Section 1: Joint Structure and Movement Learning Outcomes 8.1 Contrast the major categories of joints, and explain the relationship between structure and function for each category. 8.2 Describe the basic structure of a synovial joint, and describe common accessory structures and their functions. 8.3 Describe how the anatomical and functional properties of synovial joints permit movements of the skeleton. © 2018 Pearson Education, Inc. Section 1: Joint Structure and Movement Learning Outcomes (continued) 8.4 Describe flexion/extension, abduction/ adduction, and circumduction movements of the skeleton. 8.5 Describe rotational and special movements of the skeleton. © 2018 Pearson Education, Inc. Module 8.1: Joints are classified according to structure and movement Joints, or articulations . Locations where two or more bones meet . Only points at which movements of bones can occur • Joints allow mobility while preserving bone strength • Amount of movement allowed is determined by anatomical structure . Categorized • Functionally by amount of motion allowed, or range of motion (ROM) • Structurally by anatomical organization © 2018 Pearson Education, Inc. Module 8.1: Joint classification Functional classification of joints . Synarthrosis (syn-, together + arthrosis, joint) • No movement allowed • Extremely strong . Amphiarthrosis (amphi-, on both sides) • Little movement allowed (more than synarthrosis) • Much stronger than diarthrosis • Articulating bones connected by collagen fibers or cartilage . Diarthrosis (dia-, through) • Freely movable © 2018 Pearson Education, Inc. Module 8.1: Joint classification Structural classification of joints . Fibrous • Suture (sutura, a sewing together) – Synarthrotic joint connected by dense fibrous connective tissue – Located between bones of the skull • Gomphosis (gomphos, bolt) – Synarthrotic joint binding teeth to bony sockets in maxillae and mandible © 2018 Pearson Education, Inc. -
Embryonic Cell That Forms Cartilage Medical Term
Embryonic Cell That Forms Cartilage Medical Term Unexploited Gordie languishes: he scumbles his initiatives atweel and esthetically. When Nate gestate his niggardliness Grecizing not post-free enough, is Mikhail windowless? Ship-rigged or millionth, Edgar never enshrining any millionairesses! The crest cell phenotype research in record area forms the body of shift review the Table 1. Where and repair differs substantially augments the embryonic cartilage tissue types of its tension adaptation and cells? In both types for medicine to that cartilage. Cells turn into differentiated stem cells that trace specific tissues and organs. Ambiguous cells the emergence of daughter stem a concept in. Mesenchymal Chondrosarcoma NORD National. Blood cells Chondro Oma Cartilage Tumor Arthro Joints Cartilage creates a. Can disturb blood cells and stromal which manufacture produce fat cartilage and bone. Label by following from NURSING 3345 at University of Texas Medical Branch. Body mostly a laboratory stem cells divide that form more cells called daughter cells. Guidelines for Human Embryonic Stem Cell with Brown. Abstract The skeletal system is formed of bones and cartilage which are. Each tissue cartilage bone and skeletal muscle goes through my different. Medical terms UCL. Please note love the definitions are moving given an explain another word found also a. Definition Stem cells are cells which feature not yet developed a special. The term totipotent refer down the grief that they ever total potential to. Stem from Research Uses Types & Examples Healthline. For cardiac muscle cells and was still pluripotent stem cells may also structures and cartilage that embryonic cell forms a primitive connective tissue physiology as well as macrophages are adequately informed consent. -
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor: Rebecca Bailey 1 Chapter 1 The Human Body: An Orientation • Terms - Anatomy: the study of body structure and relationships among structures - Physiology: the study of body function • Levels of Organization - Chemical level 1. atoms and molecules - Cells 1. the basic unit of all living things - Tissues 1. cells join together to perform a particular function - Organs 1. tissues join together to perform a particular function - Organ system 1. organs join together to perform a particular function - Organismal 1. the whole body • Organ Systems • Anatomical Position • Regional Names - Axial region 1. head 2. neck 3. trunk a. thorax b. abdomen c. pelvis d. perineum - Appendicular region 1. limbs • Directional Terms - Superior (above) vs. Inferior (below) - Anterior (toward the front) vs. Posterior (toward the back)(Dorsal vs. Ventral) - Medial (toward the midline) vs. Lateral (away from the midline) - Intermediate (between a more medial and a more lateral structure) - Proximal (closer to the point of origin) vs. Distal (farther from the point of origin) - Superficial (toward the surface) vs. Deep (away from the surface) • Planes and Sections divide the body or organ - Frontal or coronal 1. divides into anterior/posterior 2 - Sagittal 1. divides into right and left halves 2. includes midsagittal and parasagittal - Transverse or cross-sectional 1. divides into superior/inferior • Body Cavities - Dorsal 1. cranial cavity 2. vertebral cavity - Ventral 1. lined with serous membrane 2. viscera (organs) covered by serous membrane 3. thoracic cavity a. two pleural cavities contain the lungs b. pericardial cavity contains heart c. the cavities are defined by serous membrane d. -
Juncturae Ossium Membri Superioris) Rndr
SPECIAL ARTHROLOGY Connections of the upper limb (juncturae ossium membri superioris) RNDr. Michaela Račanská, Ph.D. Lecture 8 – DENTISTRY – Autumn 2016 Connections of the shoulder girdle: scapula + clavicle – art. acromioclavicularis clavicle + sternum – art. sternoclavicularis Syndesmoses of the shoulder blade Connections of the free upper limb: Humerus + scapula – art. humeri Humerus + radius + ulna – art. cubiti Radius + ulna – membrana interossea antebrachii – art. radioulnaris distalis Radius + carpal bones– art. radiocarpea Carpal bones – art. mediocarpea carpal + metacarpal bones– art. carpometacarpea Metacarpal bones + phalanges proximales – art. metacarpophalangea Phalanges – art. interphalangea manus I. Articulatio sternoclavicularis Type: compound joint- discus articularis ball and socket (movements in connection to the scapula movements) A. head: facies articularis sternalis claviculae A. fossa: incisura clavicularis manubrii sterni AC: tough, short Ligaments: lig. sternoclaviculare anterius lig. sternoclaviculare posterius lig. interclaviculare lig. costoclaviculare Movements: small, to all direction II. Articulatio acromioclavicularis Type: ball and socket, sometimes discus articularis AS: facies art. acromialis (clavicula) + facies art. acromii (scapula) AC: tough, short ligaments: lig. acromioclaviculare lig. coracoclaviculare (lig. trapezoideum + lig. conoideum) lig. coracoacromiale - fornix humeri lig. transversum scapulae movements: restricted, in connections with movements in sternoclavicular joint Syndesmoses of the -
Module 6 : Anatomy of the Joints
Module 6 : Anatomy of the Joints In this module you will learn: About the classification of joints What synovial joints are and how they work Where the hinge joints are located and their functions Examples of gliding joints and how they work About the saddle joint and its function 6.1 Introduction The body has a need for strength and movement, which is why we are rigid. If our bodies were not made this way, then movement would be impossible. We are designed to grow with bones, tendons, ligaments, and joints that all play a part in natural movements known as articulations – these strong connections join up bones, teeth, and cartilage. Each joint in our body makes these links possible and each joint performs a specific job – many of them differ in shape and structure, but all control a range of motion between the body parts that they connect. 6.2 Classifying Joints Joints that do not allow movement are known as synarthrosis joints. Examples of synarthroses are sutures of the skull, and the gomphoses which connect our teeth to the skull. Amphiarthrosis joints allow a small range of movement, an example of this is your intervertebral discs attached to the spine. Another example is the pubic symphysis in your hip region. The freely moving joints are classified as diarthrosis joints. These have a higher range of motion than any other type of joint, they include knees, elbows, shoulders, and wrists. Joints can also be classified depending on the kind of material each one is structurally made up of. A fibrous joint is made up of tough collagen fiber, examples of this are previously mentioned sutures of the skull or the syndesmosis joint, which holds the ulna and radius of your forearm in place. -
Autologous Matrix-Induced Chondrogenesis and Generational Development of Autologous Chondrocyte Implantation
Autologous Matrix-Induced Chondrogenesis and Generational Development of Autologous Chondrocyte Implantation Hajo Thermann, MD, PhD,* Christoph Becher, MD,† Francesca Vannini, MD, PhD,‡ and Sandro Giannini, MD‡ The treatment of osteochondral defects of the talus is still controversial. Matrix-guided treatment options for covering of the defect with a scaffold have gained increasing popularity. Cellular-based autologous chondrocyte implantation (ACI) has undergone a generational development overcoming the surgical drawbacks related to the use of the periosteal flap over time. As ACI is associated with high costs and limited in availability, autologous matrix-induced chondrogenesis, a single-step procedure combining microfracturing of the subchondral bone to release bone marrow mesenchymal stem cells in combination with the coverage of an acellular matrix, has gained increasing popularity. The purposes of this report are to present the arthroscopic approach of the matrix-guided autologous matrix-induced chondrogenesis technique and generational development of ACI in the treatment of chondral and osteochon- dral defects of the talus. Oper Tech Orthop 24:210-215 C 2014 Elsevier Inc. All rights reserved. KEYWORDS cartilage, defect, ankle, talus, AMIC, ACI Introduction Cartilage repair may be obtained by cartilage replacement: (OATS, mosaicplasty) or with techniques aimed to generate a hondral and osteochondral lesions are defects of the newly formed cartilage such as microfracture or autologous Ccartilaginous surface and underlying subchondral bone of chondrocyte implantation (ACI).9-17 the talar dome. These defects are often caused by a single or Arthroscopic debridement and bone marrow stimulation multiple traumatic events, mostly inversion or eversion ankle using the microfracture technique has proven to be an 1,2 sprains in young, active patients. -
Chapter 14. Anthropometry and Biomechanics
Table of contents 14 Anthropometry and biomechanics........................................................................................ 14-1 14.1 General application of anthropometric and biomechanic data .....................................14-2 14.1.1 User population......................................................................................................14-2 14.1.2 Using design limits ................................................................................................14-4 14.1.3 Avoiding pitfalls in applying anthropometric data ................................................14-6 14.1.4 Solving a complex sequence of design problems ..................................................14-7 14.1.5 Use of distribution and correlation data...............................................................14-11 14.2 Anthropometric variability factors..............................................................................14-13 14.3 Anthropometric and biomechanics data......................................................................14-13 14.3.1 Data usage............................................................................................................14-13 14.3.2 Static body characteristics....................................................................................14-14 14.3.3 Dynamic (mobile) body characteristics ...............................................................14-28 14.3.3.1 Range of whole body motion........................................................................14-28 -
Module 2 : Anatomy – the Skeleton
Module 2 : Anatomy – The Skeleton In this module you will learn: The functions of the skeletal system The types of bones in the human body The effects of exercise on your bones What happens to the bones as we get older When studying to become a fitness instructor or personal trainer, you will learn all about the anatomy of the human body. Studying the skeleton is one of the foundations of your trade, you will need to know how the body is structured, the names of each bone, types of bones, importance of bone and joint health, detail of the spine and different terms of movement. Without stating the obvious, each of your clients has their own skeleton and you must be fully aware of how this works. This is for many reasons; you are a teacher and must be fully aware of how to prevent injuries, avoid unnecessary stress on the bones and, if qualified, help the client prevent or heal bone and joint related conditions or medical problems. 2.1 Understanding the Skeletal System The skeleton is comprised of 206 different bones that provide 5 main functions: Support mechanism for muscle and tissue Protection for organs Movement with bones, muscles, and joints Storing minerals and blood cells Growth Skeletal System 2.2 Bones are Formed by Ossification Some bones (such as the flat bones of your skull) in the body are formed in a similar stage to connective tissue. The process is known as direct or intramembranous ossification. Other bones are made up of cartilaginous matter, this is developed from future bone in the embryo which then dissolves and is replaced with other bone cells.