i Current Topics in Medicinal Chemistry, 2019, Vol. 19, No. 14 Graphical Abstracts Graphical Abstracts

Current Topics in Medicinal Chemistry; Vol. 19, No. 14, 2019, 1191 In Vitro and In Silico Studies of Glycyrrhetinic Acid Derivatives as Anti-Filarial Agents

Rekha Tyagi, Surjeet Verma, Shikha Mishra, Mrigank Srivastava, Sarfaraz Alam, Feroz Khan and Santosh K. Srivastava*

*Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India

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Current Topics in Medicinal Chemistry; Vol. 19, No. 14, 2019, 1201 Bioactive Natural and Synthetic Peroxides for the Treatment of Helminth and Protozoan Pathogens: Synthesis and Properties

Vera A. Vil’, Alexander O. Terent’ev* and Olga M. Mulina

*N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47, Moscow, 119991, Russian Federation; All-Russian Research Institute for Phytopathology, 143050, B. Vyazyomy, Moscow Region, Russian Federation

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Parasitic Schistosoma H O O O COOH worms: Fasciola O H O Plakinic acid B Artemisinin Protozoans: Leishmania O O O NH2 Trypanosoma O O N O H COOH Plakortide E Toxoplasma Arterolane

Graphical Abstracts Current Topics in Medicinal Chemistry, 2019, Vol. 19, No. 14 ii

Current Topics in Medicinal Chemistry; Vol. 19, No. 14, 2019, 1226 Strategies to Control Human Lymphatic Filarial Infection: Tweaking Host’s Immune System Puvvada K. Murthy* *Department of Zoology, University of Lucknow, University Road, Lucknow 226 007, Uttar Pradesh, India

      

                   

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Strategies for control of lymphatic filariasis. Current Topics in Medicinal Chemistry; Vol. 19, No. 14, 2019, 1241 Vanillin-Related N-Acylhydrazones: Synthesis, Antischistosomal Properties and Target Fishing Studies

Daniela G.G. Rando, Marcela O.L. da Costa, Thais F.A. Pavani, Thiago Oliveira, Paloma F. dos Santos, Carina R. Amorim, Pedro L.S. Pinto, Mariana G. de Brito, Marcos P.N. Silva, Daniel B. Roquini and Josué de Moraes*

*Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil

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HC3 CH3 LC 47.91 mM Er Td 50: Tu SI: 4.14 SI

Potential Targets iii Current Topics in Medicinal Chemistry, 2019, Vol. 19, No. 14 Graphical Abstracts

Current Topics in Medicinal Chemistry; Vol. 19, No. 14, 2019, 1252

In Vitro and In Vivo Antifilarial Activity of Standardized Extract of Calotropis procera Flowers against Brugia malayi

Vikas Kushwaha, Subha Rastogi, Madan Mohan Pandey, Kirti Saxena, Sayyada Khatoon, Ajay Kumar Singh Rawat and P. Kaplana Murthy*

*Division of Parasitology, CSIR-Central Drug Research Institute, New Campus, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India

50 Male Female 40 Total Ster. Female

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20 * * ** *** *** 10 Parasite load (Mean + SD) 0 Control A001 F001 DEC-c 600 Control F001 *** 400 ** ** ** * * 200 ** Mf count in blood * ** * 0 0 1428 4256 70 8498 R1 R2F001 F001 R3 Days post-treatment

Ethanolic extract (A001) and its hexane fraction (F001) of Calotropis procera flowers showed macrofilaricidal activity and suppression in microfilaraemia in Brugia malayi-Mastomys coucha. F001 contained lupeol (R1), β-sitosterol (R2) and triacontanol (R3).

Graphical Abstracts Current Topics in Medicinal Chemistry, 2019, Vol. 19, No. 14 iv

Current Topics in Medicinal Chemistry; Vol. 19, No. 14, 2019, 1263 Immunochemical Characterization of Setaria cervi Microfilarial Antigens Using Novel Antibodies

Anuradha Kalani*, Komal Kalani, Poonam Chaturvedi and Pankaj Chaturvedi

*Department of Medicine, University of Louisville, Louisville, KY 40202, USA 1A 1B

Cf Counting ScMF ScEmb ScMf purify ScEmb 800xg 1st experiment 3.9x106 6.2x104 98.4 15 min 2nd experiment 3.9x106 6.0x104 98.4

rd 6 4 ScMf 3 experiment 4.0x10 5.4x10 98.7 Mean Count 3.9x106 5.9x104 98.5

Purity of S. cervi microfilariae after purification on a two-step percoll gradient.