Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol

Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 i Graphical Abstracts

Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 686 Detection of Natural Inhibitors against Human Liver Cancer Cell Lines through QSAR, Molecular Docking, and ADMET Studies

Sarfaraz Alam, Sadaf Nasreen, Ateeque Ahmad, Mahendra Pandurang Darokar and Feroz Khan*

*Metabolic & Structural Biology Department, CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow 226015 (Uttar Pradesh), India

Training Test Set

Drug/Lead O Predicted Activity Predicted Likeness HO NH O HN HO Experimental Activity OH 50 O 40 Target 30 identific ADMET O 20 S 10 ation HN 0 O -10 Contribution(%) O Descriptor -index Mol. Wt. Epsilon3 MMFF_10

calculation QSAR SaaOE-index Screening Docking Model Leads

In-silico identification of natural inhibitors active against human liver cancer cell line. (A higher resolution / colour version of this figure is available in the electronic copy of the article).

Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 696 Role of Extracellular Vesicles in Glioma Progression: Deciphering Cellular Biological Processes to Clinical Applications

Rashmi Rana*, Shikha Joon, Kirti Chauhan, Vaishnavi Rathi, Nirmal Kumar Ganguly, Chandni Kumari and Dharmendra Kumar Yadav**

*Department of Research, Sir Ganga Ram Hospital, New Delhi-110060, India; **Gachon Institute of Pharmaceutical Science and Department of Pharmacy, College of Pharmacy, Gachon University, Incheon, Republic of Korea

Graphical overview of extracellular vesicles production from glioma cells and their role in diagnostic, prognostic and therapeutics. (A higher resolution / colour version of this figure is available in the electronic copy of the article). ii Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 Graphical Abstracts

Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 705 Organic Antifungal Drugs and Targets of Their Action

Alexander Yu. Maksimov*, Svetlana Yu Balandina, Pavel A. Topanov, Irina V. Mashevskaya and Sandeep Chaudhary

*Department of Pharmacy and Pharmacology, Faculty of Chemistry, Perm State University, Perm, 614990, Russia

Inhibition of ergosterol biosynthesis.

Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 737 Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance

Harish C. Upadhyay*

*Laboratory of Chemistry, Department of Applied Sciences, Rajkiya Engineering College (Affiliated to Dr. A.P.J. Abdul Kalam Tech- nical University, Lucknow), Churk, Sonbhadra-231206, India

Antimicrobial activity Gram-positive strains R Gram-negative strains L M. tuberculosis I N N K Fungal strains E R O O N N Coumarin-1,2,3-triazoles

The above figure shows the coumarin-1,2,3-triazole hybrid molecules. (A higher resolution / colour version of this figure is available in the electronic copy of the article).

Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 iii

Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 753 Therapeutic Potential of microRNA Against Th2-associated Immune Disorders

Sunil Kumar, Muhammad Umer Ashraf, Anil Kumar and Yong-Soo Bae*

*Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea

5 3 3 5 DNA mature miRNA

RISC ssRNA Asthma RNA Pol-II miRNA- pri-miRNA Drosha miRNA* duplex (100-120 nt) (DGCR8) Dicer RNaseIII pre-miRNA (65-75 nt) Exportin-5

Immune cell Atopic dermatitis

Therapeutic microRNAmodulating Th2-associated immune disorders. (A higher resolution / colour version of this figure is available in the electronic copy of the article).