Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 i Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 686 Detection of Natural Inhibitors against Human Liver Cancer Cell Lines through QSAR, Molecular Docking, and ADMET Studies Sarfaraz Alam, Sadaf Nasreen, Ateeque Ahmad, Mahendra Pandurang Darokar and Feroz Khan* *Metabolic & Structural Biology Department, CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow 226015 (Uttar Pradesh), India Training Test Set Drug/Lead O Predicted Activity Predicted Likeness HO NH O HN HO 8 8 8 8 8 Experimental Activity OH 50 O 40 Target 30 identific ADMET O 20 S 10 ation HN 0 O -10 Contribution(%) O Descriptor -index Mol. Wt. Epsilon3 MMFF_10 calculation QSAR SaaOE-index Screening Docking Model Leads In-silico identification of natural inhibitors active against human liver cancer cell line. (A higher resolution / colour version of this figure is available in the electronic copy of the article). Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 696 Role of Extracellular Vesicles in Glioma Progression: Deciphering Cellular Biological Processes to Clinical Applications Rashmi Rana*, Shikha Joon, Kirti Chauhan, Vaishnavi Rathi, Nirmal Kumar Ganguly, Chandni Kumari and Dharmendra Kumar Yadav** *Department of Research, Sir Ganga Ram Hospital, New Delhi-110060, India; **Gachon Institute of Pharmaceutical Science and Department of Pharmacy, College of Pharmacy, Gachon University, Incheon, Republic of Korea %IQ`HVCC ^$C1QI:_ %IQ`R1:$JQ 1H:JR `Q$JQ 1HG1QI:`@V` J.:JHVR]`QR%H 1QJ nV.1HCV G7 %IQ`HVCC %IQ` .V`:]V% 1H Graphical overview of extracellular vesicles production from glioma cells and their role in diagnostic, prognostic and therapeutics. (A higher resolution / colour version of this figure is available in the electronic copy of the article). ii Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 705 Organic Antifungal Drugs and Targets of Their Action Alexander Yu. Maksimov*, Svetlana Yu Balandina, Pavel A. Topanov, Irina V. Mashevskaya and Sandeep Chaudhary *Department of Pharmacy and Pharmacology, Faculty of Chemistry, Perm State University, Perm, 614990, Russia Inhibition of ergosterol biosynthesis. Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 737 Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance Harish C. Upadhyay* *Laboratory of Chemistry, Department of Applied Sciences, Rajkiya Engineering College (Affiliated to Dr. A.P.J. Abdul Kalam Tech- nical University, Lucknow), Churk, Sonbhadra-231206, India Antimicrobial activity Gram-positive strains R Gram-negative strains L M. tuberculosis I N N K Fungal strains E R O O N N Coumarin-1,2,3-triazoles The above figure shows the coumarin-1,2,3-triazole hybrid molecules. (A higher resolution / colour version of this figure is available in the elec- tronic copy of the article). Graphical Abstracts Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 iii Current Topics in Medicinal Chemistry, 2021, Vol. 21, No. 8 753 Therapeutic Potential of microRNA Against Th2-associated Immune Disorders Sunil Kumar, Muhammad Umer Ashraf, Anil Kumar and Yong-Soo Bae* *Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea 5 3 3 5 DNA mature miRNA RISC ssRNA Asthma RNA Pol-II miRNA- pri-miRNA Drosha miRNA* duplex (100-120 nt) (DGCR8) Dicer RNaseIII pre-miRNA (65-75 nt) Exportin-5 Immune cell Atopic dermatitis Therapeutic microRNAmodulating Th2-associated immune disorders. (A higher resolution / colour version of this figure is available in the electronic copy of the article). .