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Home , Bleeding, Bruise, Hemarthrosis, Intracranial hemorrhage

Hemorrhage http://www.docstoc.com/docs/106382628/Hematocrit-plasma-and- serum http://www.cdha.nshealth.ca/system/files/hemolysis.jpg http://www.pxbiovision.com/science/science/science/preanalyticalPhase_files/ stacks_image_34.png http://upload.wikimedia.org/wikipedia/commons/4/42/Classical_blood_coagulation_pathway.png Extrinsic

http://www.varnerlab.org/storage/post-images/Fig_1_Network-Coagulation.png?__SQUARESPACE_CACHEVERSION=1255571758345 Intrinsic Prothrombin Time Test-PT

This test is done to evaluate the blood for its ability to clot. It is often done before to evaluate how likely the patient is to have a or clotting problem during or after surgery.

Normal PT Values: 10-12 seconds (this can vary slightly from lab to lab) Common causes of a prolonged PT include deficiency, drugs including replacements and oral contraceptives, disseminated intravascular (a serious clotting problem that requires immediate intervention), disease, and the use of the anti-coagulant drug . Additionally, the PT result can be altered by a diet high in vitamin K, liver, green tea, dark green vegetables and soybeans.

http://www.intechopen.com/source/html/42171/media/i http://surgery.about.com/od/beforesurgery/qt/PTPTTINRtests.htm mage3_w.jpg Partial Thromboplastin Time Blood Test-PTT This test is performed primarily to determine if heparin (blood thinning) therapy is effective. It can also be used to detect the presence of a clotting disorder. It does not show the effects of drugs called “low molecular weight heparin” or most commonly by the brand name Lovenox.

Normal PTT Values: 30 to 45 seconds (this can value slightly from lab to lab) Extended PTT times can be a result of anticoagulation therapy, liver problems, lupus and other diseases that result in poor clotting.

http://www.intechopen.com/source/html/42171/media/i mage3_w.jpg http://surgery.about.com/od/beforesurgery/qt/PTPTTINRtests.htm INR=(PT patient/PT normal)ISI International Normalized Ratio Blood Test-INR PT patient = patient's measure PT (seconds) Normal INR Values: 1 to 2 The INR is used to make sure the results PT normal = laboratory's from a PT test is the same at one lab as it geometric mean value for normal is at another lab. In the 1980’s the World patients (seconds) Health Organization determined that patients may be at risk because the results ISI = International Sensitivity Index of a PT test would vary from one lab to another, based upon the way the test was http://easycalculation.com/medical/inr.php done. The “normal” range for one lab would be different than a “normal” value from another lab, creating problems for patients who were being treated in several locations. In order to standardize the results between labs, the INR was created. The INR result should be the same, regardless of the location where the tests are performed.

http://surgery.about.com/od/beforesurgery/qt/PTPTTINRtests.htm http://www.mayomedicallaboratories.com/images/articles/hottopics/2008/2008 -10-pvariables/slide7.jpg

http://www.lienchiny.com.tw/UserFiles/pd/P2010120800096_S.jpg Figure 3 Action of LMWHs on the traditional coagulation cascades, showing coagulation factors PKK and HMWK

Davenport, A. (2011) What are the anticoagulation options for intermittent hemodialysis? Nat. Rev. Nephrol. doi:10.1038/nrneph.2011.88

Tissue factor pathway inhibitor (or TFPI) Primary hemostatic clot formation • are activated by contact with Extra Cellular Matrix • Circulating tethers glycoprotein receptors to ECM collagen • Thrombin is released to cleave creating nets that capture more platelets as well as RBCs and WBCs • Platelets contract with microtubular contractile proteins, consolidating plug

Fibrinolysis D-dimer is the degradation product of crosslinked (by factor XIII) fibrin.

It reflects ongoing activation of the hemostatic system. http://emedicine.medscape.com/article/2085111-overview

http://ahdc.vet.cornell.edu/sects/coag/test/D-dimer.gif Hemostatic clot resolution

• tPA, plasminogen activator, cleaves plasminogen to plasmin • Plasmin digests fibrin clot • Tightly regulated yin-yang of http://lifeinthefastlane.com/wp-content/uploads/2010/05/D-dimer- flowchart.jpg Hemorrhage Extravasation of blood into the extravascular space.

Capillary bleeding can occur under conditions of chronic congestion.

Rupture of a large artery or vein results in severe hemorrhage and is almost always due to vascular , including trauma, atherosclerosis, or inflammatory or neoplastic erosion of the vessel wall. Bleeding

http://www.glowm.com/resources/glowm/graphics/figures/v2/108 0/15.jpg

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Hemorrhage may be external or contained within a tissue.

Any accumulation is called a .

Hematomas may be relatively insignificant or so massive that ensues.

http://media.zenfs.com/en_us/News/YahooSports/1304308620.jpg http://ars.els-cdn.com/content/image/1-s2.0-S1878764912000241-gr1.jpg The Ocular Pathology of Terson's Syndrome

http://www.sciencedirect.com/science/article/pii/S0161642009013852 Hematoma--subdural http://www.daviddarling.info/images/spleen_cross-section.jpg Subcapsular Hematoma

http://www.vetmed.vt.edu/education/curriculum/vm83 04/lab_companion/histo- path/vm8054/labs/Lab13/Images/LYMPL28.JPG Minute 1- to 2-mm hemorrhages into skin, mucous membranes, or serosal surfaces are called petechiae

These are most commonly associated with locally increased intravascular pressure, low platelet counts (), or defective platelet function (as in ). Figure 3Kinetics of inflammatory bleeding in thrombocytopenic mice during reverse passive . (A) Photographs of progressing rpA in the dorsal skinfold chamber. In the absence of platelets, petechial bleeding was clearly visible after 2 hours and increased with time. In nondepleted animals there were virtually no petechial spots. Window diameter was 12 mm. (B) Microscopic view of the progressing rpA in a thrombocytopenic mouse. Petechial bleeding was detected at 20 minutes, with further growth of the spot at 40 minutes. Bar = 200 μm. (C) Petechial spots visible to the eye ( 100 μm) were counted during rpA in thrombocytopenic and control animals. The∼ difference in incidence of petechiae became statistically significant within 1 hour (P < .01; n = 4). At t = 4 hours, the petechiae became confluent, impairing quantification. Error bars http://bloodjournal.hematologylibrary.org/content represent SEM. /111/10/4958/F3.expansion Slightly larger (≥3 mm) hemorrhages are called .

These may be associated with many of the same disorders that cause petechiae or can be secondary to trauma, vascular (), or increased vascular http://www.healthandphysicaleducationteacher.com/wp- content/uploads/2011/05/Purpura-2-300x223.jpg fragility (e.g., in amyloidosis). http://openi.nlm.nih.gov/detailedresult.php?img=3175359_cde0003- 0022-f02&req=4

Figure 2: Microscopic examination of palpable purpura. Severe pandermal leucocytoclastic vasculitis without granulation (HE, original magnification ×40; inset: http://25.media.tumblr.com/tumblr_li2muuU9eb1qg1up7o1_500.jpg ×400). http://www.pediatrics.wisc.edu/education/derm/tutb/48m.jpg Larger (>1 to 2 cm) subcutaneous hematomas (i.e., ) are called ecchymoses.

The red cells in these lesions are degraded and phagocytized by macrophages; the (red-blue color) is then enzymatically converted into (blue- green color) and eventually into

(gold-brown color), accounting for the fig-002: Continuing hemorrhagic drainage and a characteristic color changes in a . massive ecchymosis on right side in spite of primary surgical hemostatis.

Mentions: The patient developed a large right lumbar ecchymosis while daily drainage volume remained 150- 200 ml (Figure 2). Hemoglobin level dropped to 8.9 g and hematocrit to 26.6%. He was still complaining of considerable pain in spite of medications. A re- exploration was decided on day-5. Previous incision was re-opened with infiltration. A pulsatile hemorrhage was seen from an approximately 1-mm vessel. Despite this vessel was ligated the hemorrhage kept continuing. The operating team concluded to try hemostatic matrix [FloSeal®, Baxter] http://openi.nlm.nih.gov/detailedresult.php?img=2740183_1757-1626- for definitive hemostasis. After applying this novel 0002-0000006353- hemostatic agent the bleeding stopped (Figure 3). 002&query=the&fields=all&favor=none&it=none&sub=none&sp=none& req=4&simCollection=2605750_1755-8794-1-57-1&npos=32&prt=3 Ecchymoses or contusions Hemorrhage into cavities • Pleural hemorrhage— . Build-up of pressure prevents expansion • Prevents gas exchange • May lead to lung collapse . Instigates coughing or hiccups, which exacerbates bleeding • Pericardial hemorrhage— . Build-up of external pressure inhibits filling . = compression • . Always bad because of the rigid cranium . CSF pressure increases rapidly if bleeding rate is greater than rate of fluid resorption Depending on the location, a large accumulation of blood in a body cavity is denoted as a hemothorax, hemopericardium, , or (in ).

Patients with extensive bleeding can develop jaundice from the massive breakdown of red cells and hemoglobin.

http://dccdn.de/pictures.doccheck.com/photos/2/9/257524c9e808999_m.jpg Hemopericardium

This is hemopericardium as demonstrated by the dark blood in the pericardial sac opened at . or massive blunt force trauma to the chest (often from the steering wheel) causes a rupture of the myocardium and/or coronary arteries with bleeding into the pericardial cavity. The extensive collection of blood in this closed space leads to cardiac tamponade. A , with needle inserted into the pericardial cavity, can be a diagnostic procedure. The clinical significance of hemorrhage depends on the volume and rate of bleeding.

Rapid loss of up to 20% of the blood volume or slow losses of even larger amounts may have little impact in healthy adults; greater losses, however, can cause hemorrhagic (hypovolemic) .

The site of hemorrhage is also important. For example, bleeding that is trivial in the subcutaneous tissues can cause death if located in the ; because the is unyielding, intracranial hemorrhage can result in an increase in pressure that is sufficient to compromise the blood supply or to cause the herniation of the .

Finally, chronic or recurrent external blood loss (e.g., peptic or menstrual bleeding) causes a net loss in iron and can lead to an . In contrast, when red cells are retained (e.g., hemorrhage into body cavities or tissues), iron is recovered and recycled for use in the synthesis of hemoglobin. Heparin

http://www.nature.com/nrd/journal/v1/n2/images/nrd724-f2.gif Warfarin/Courmarins

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http://www.springerimages.com/img/Images/Springer/PUB=Springer-Verlag- New_York/JOU=11606/VOL=2009.24/ISU=5/ART=2009_951/MediaObjects/MEDIU M_11606_2009_951_Fig1_HTML.jpg Shock

Shock is the final common pathway for several potentially lethal clinical events, including severe hemorrhage, extensive trauma or , large , massive pulmonary , and microbial sepsis.

Shock is characterized by systemic due either to reduced cardiac output or to reduced effective circulating blood volume.

The consequences are impaired tissue perfusion and cellular . At the outset the cellular injury is reversible; however, prolonged shock eventually leads to irreversible tissue injury that often proves fatal. http://2.bp.blogspot.com/_FH_Gso1F6Rg/S9koggPodhI/AAAAAAAAAxA/dLTT 0fBNzRA/s400/hypoglycemia_bugs.jpg http://www.scripps.org/encyclopedia/graphics/images/en/17231.jpg http://upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Shock-cell2.svg/500px-Shock-cell2.svg.png