UNIVERSITY OF PENNSYLVANIA MEDICAL CENTER SPRING 2001

Garret FitzGerald, Renaissance Man CLINICAL CARE PENNSYLVANIA HOSPITAL REACHES 250 Editor’s Note

Then and Now In the Spring of 1948, Spencer physician on duty. From church, was a second-year medical student Spencer knew Scott‘s parents, who n the May 1949 issue of U.M.A. when he visited a Sunday evening had been missionaries in China. News, published by Penn’s religious service at the Central What experience did Spencer him- Undergraduate Medical Associa- Gospel Hall Mission. Seeing the 750 self have as a volunteer? “None I homeless men made “an everlasting whatsoever,” he says. He explains tion, an article reported that a newly established “medical mission impression” on him. “All I could that David Baker “wanted me to be in the center of Philadelphia is pro- remember was a sea of faces and a preacher,” but Spencer preferred viding care and thoughtful treat- people coughing and groaning,” he to help other people through medi- ment” to the needy. The providers says today. Spencer discussed the cine. In March of 1949, the two mis- were some 15 to 20 medical stu- situation with David W. Baker, also sion clinics opened. There were dents. “Students from all classes in a second-year medical student at only two patients that first evening, the University Medical School have Penn — and an ordained Presbyter- Spencer recalls, but the numbers given their time on Sunday after- ian minister. They soon developed increased steadily to about 30 per noons and evenings, as have sever- the idea of establishing clinics for evening. In addition to Baker and al practicing physicians in the area, the homeless, at Central Gospel Hall Spencer, other medical students th and the work has been in progress Mission and at the 8 Street Wayside who attended the very first sessions for several weeks.” Mission. Both sites underwent included Margaret (Peggy) Potter At the Central Gospel Hall Mis- extensive cleaning and remodeling. and William J. Erdman, as well as sion, at 222 North 12th Street, the According to Spencer, the Graduate Robert Carpenter, a medical student medical students might typically Hospital donated the bulk of the at Temple University. Elizabeth examine 20 to 30 patients. As the equipment, including two low beds; Flynn, a medical technician at the U.M.A. News put it, “Histories, two examination tables; and two University hospital, served as regis- physicals, and diagnoses are made. electric sterilizers. Its chief of trar and secretary. The directing physician is consult- surgery, Dr. William Bates, also From the start, the clinics did not ed. If the case requires minor treat- donated several medical instru- lack for help. “There were more stu- ment, such is undertaken. If the ments. Many others contributed. dents who wanted to volunteer patient requires hospital attention, Getting approval from the vari- than we had places for,” says he is sent to a hospital with a note.” ous organizations, including the Spencer. Originally, participation in One of the medical students who county medical society, took some the clinics was limited to members helped start the medical mission is doing. For legal reasons, the term of the Christian Medical Society, but H. Newton Spencer, M.D. ‘50, G.M.E. “counseling service” was used that decision was soon changed. ‘58, who has written an account of instead of “clinic.” Spencer notes the Among the people who joined the its planning and development. In help of Dr. Elizabeth Ravdin, the society around this time was C. this issue of Penn Medicine, Marie wife of Dr. I. S. Ravdin, the chief of Everett Koop, M.D., G.M.E. ‘47, Gehret describes the activities of surgery. He had taken the submitted then assistant professor of surgery several current Penn medical stu- plan home to read, but it was she at Penn and surgeon-in-chief at The dents who are running two clinics who read it first — and urged her Children‘s Hospital of Philadelphia. in West Philadelphia. It is interesting husband to support it at the next Koop succeeded Scott as graduate to compare the two student initia- faculty meeting. Dr. John M. director of the mission clinics. tives some 50 years apart. The chief Mitchell, then dean of the medical Today, Spencer, of Ardmore, Pa., similarity, as one might expect, is school, at first discouraged the con- has retired from orthopaedic surgery the call to service felt by the young cept of a student-run clinic because but remains an instructor, as well as men and women in 1949 and 2001. he was afraid it would not survive a consultant on occupational health. Both groups were seeking to help more than a year. Although the During his career, he continued other people while gaining experi- medical counseling service was dis- some of the work he began with the ence that would help them hone continued for the summer months, student clinic. While serving in the their skills as caregivers. One of the it returned the next semester and, Air Force in Korea (1953-54), for apparent differences, however, is the says Spencer, continued for many example, he helped rebuild and strong religious impetus of those years thereafter, “until Medicare restock bombed-out hospitals. He students of 1949. Although both was implemented in 1968.” also used to travel regularly to Haiti, clinics run by today‘s Penn students Spencer asked Dr. Kenneth Scott, to perform surgery on children at are housed in West Philadelphia a Penn graduate, to be the licensed the Albert Schweitzer Hospital. Ear- churches, the rest of the initiative lier this year, Spencer was delighted seems largely secular. On the other to hear about President Bush‘s hand, the student founders of the creation of an Office of Faith-Based clinics — or medical missions — in and Community Initiatives. In 1949 were members of the Christian Spencer‘s experience, those initia- Medical Society at Penn. tives can work.

Cover: Garret A. FitzGerald, M.D. Photograph by Tommy Leonardi. The Last Word

Contexts, Challenges, and Our flexibility is further compro- Change mised because our cash and invest- ments dwindled over the years 1997 through 1999 to a low level for a s you can read elsewhere in health system of our size. this issue, on February 16, We must particularly keep in President Judith Rodin, A mind the care and feeding of the Ph.D., announced the recommenda- academic programs. In recent years, tions of a special committee of Uni- very large transfers were made from versity trustees and members of our the health-services component to the medical faculty that had been School of Medicine, sometimes at the charged with examining the status of level of $100 million per year. Much the University of Pennsylvania creating its own board of trustees of this funding was used for building Health System. The most significant and executive committee; pursuing projects, specifically, the Stellar- change recommended by the com- vertical integration of the Health Chance Laboratories and Biomedical mittee was the formation of a new System; establishing an “inner Research Building II/III. This spend- not-for-profit entity that would com- ring/outer ring” policy; and acquir- ing is obviously no longer possible in prise the health-services components ing physician practices and hospitals. the current climate, or even neces- of the Health System. A few weeks There were two major reasons for sary, but a significant transfer of dol- before that, however, the Medical our fiscal difficulties that resulted in lars from the health-services compo- Faculty Senate sponsored a faculty our unprecedented $350 million oper- nent to the School of Medicine on an symposium to present perspectives ating deficit for the three years 1997- annual and predictable basis is nec- on academic medical centers and the 1999: the changing reimbursement essary to meet the requirements for marketplace. Although the focus of climate nationally and here in the annual reinvestment in the academic the symposium was national, the Delaware Valley, and the failure of enterprise. These investments general trends apply to Penn as well. the anticipated full-risk scenario to include recruitment of new chairs, The high attendance at this event evolve. Yet the subsequent turn- new faculty, renovation of academic demonstrated beyond all doubt that around in FY 2000 was equally dra- facilities, planned maintenance, and our faculty members care very much matic: UPHS went from a $200 mil- honoring prior commitments. In FY how and where they do their work. lion operating loss in FY 1999 to a $30 2000, the School managed to close its My chief role at the symposium million operating loss in FY 2000, and budget but only through strenuous was to provide the context for the that was fairly close to budget. For efforts. This year, the School is stay- strategic planning at Penn. That con- the first six months of FY2001, the ing on budget with help, but our cir- text, I believe, explains why the spe- Health System is approximately $18.5 cumstances are still constrained. cial committee made the recommen- million ahead of budget and $20 mil- Looking to the future, we see a dations it did. For a start, strategic lion in the black. Our improved oper- need for additional reinvestment and planning at Penn has been going on ating performance is real and reflects renewal sources for the School of continuously for many years, occa- extraordinary efforts by everyone: the Medicine in additional amounts sionally leading to major changes. faculty in clinical departments, their between $20 million and $30 million For example, in 1986, the University chairs, all the staff, and the health-serv- per year. The School will look again trustees formed the Medical Center vices administration led by Robert D. to the health-services component for and created the CEO/Dean position, Martin, Ph.D. a significant part of these financial putting the Hospital of the Universi- Although the operating perfor- flows, but it must also look to itself, ty of Pennsylvania and the School of mance has been praiseworthy, the to its own development efforts, to Medicine under the same adminis- balance sheet and the capital needs other new sources of revenue, and to trative leadership. Edward J. Stemm- of the health-services component new efficiencies with which to ler, M.D. ’60, was the first to serve in present a large and ever-present reduce expenses. the role of CEO/Dean. I was the sec- dilemma. The Health System’s mar- These are the challenges we face. ond, but in an interim capacity. gin is small in relation to its annual Tough choices will have to be made, Before that time, HUP reported budget of more than $1.6 billion. but I see no reason for doom and directly but separately to a Vice Pres- Capital spending last year and this gloom. Our educational programs are ident for Health Affairs in the Uni- year has been relatively spare, and excellent. The intellectual climate in versity, and the four health-related more capital spending than the cur- the School and the quality of our fac- schools, including Medicine, also rent level will be needed in the ulty and students are at an all-time reported directly but as separate enti- future both for replacement and high. Change is ever present, and ties to the same Vice President for renewal and for new technology. In adapting to change continuously is the Health Affairs. addition, the liabilities of the Health means by which we preserve – and Over the first few years after System include some $800 million in augment – our academic missions. William N. Kelley, M.D., arrived as long-term debt. In total, liabilities the next CEO/Dean, a number of comprise a substantial fraction of the strategic changes were made. These assets – that is, $1.4 billion in liabili- Arthur K. Asbury, M.D. included forming the Health System; ties and $1.8 billion dollars in assets. Interim Dean, School of Medicine UNIVERSITY OF PENNSYLVANIA MEDICAL CENTER / SPRING 2001 VOLUME XIV, NUMBER 2

CONTENTS

A MAN OF MANY PARTS Early in his career in Ireland, Dr. Garret By Kristine Conner FitzGerald may have struggled to establish his 6 own reputation – he shared a name with one of that nation’s most famous politicians. Now, FitzGerald, a busy department chair at Penn Med, has made a name for himself through his medical and pharmacological research. But he believes in the necessity of collaboration, argu- ing “Art is I; science is we.”

CLINICAL CARE In West Philadelphia, Penn medical students By Marie Gehret run and staff two clinics, which offer them “a 12 chance to help people.” Working at the clinics also offers students an opportunity to gain valuable experience in dealing with patients, especially those they typically might not see in a formal clinical clerkship.

THE FIRST TURNS 250 From its founding in 1751 as the colonies’ first hospital, Pennsylvania Hospital has played 18 an important role in the medical history of Philadelphia and the nation. The close rela- tionship with Penn’s School of Medicine goes back to the school’s very founding, and some of medicine’s major figures were associated with both institutions.

DEPARTMENTS EDITOR’S NOTE Inside Front LETTERS 5 Then and Now ALUMNI NEWS 20 VITAL SIGNS 2 Progress Notes A new direction for the Health System More honors for Armstrong THE LAST WORD Inside Back Stretching neurons to induce growth Contexts, Challenges, and Change Penn scores high in the rankings again

STAFF JOHN R. SHEA, Ph.D. Editor

LEWIS & NOBEL DESIGN Design / Art Direction

ADMINISTRATORS REBECCA HARMON Chief Public Affairs Officer MARCIA L. ROBERTS Director of Medical Alumni Relations and Institutional Events

Penn Medicine is published for the alumni and friends of the University of Pennsylvania Medical Center by the Office of Public Affairs. © 2001 by the Trustees of the University of Pennsylvania. All rights reserved. Address all correspondence to John Shea, Penn Medicine, 2018 Penn Tower, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4385, or call (215) 662-4802, or e-mail john.shea @uphs.upenn.edu.

2001/SPRING 1 VitalSigns

A new “direction” for the ulty and staff that, despite increas- Health System ing rumors to the contrary, the committee had not made its rec- n February 16, Judith ommendations. So it was not sur- Rodin, Ph.D., president of prising that Rodin’s announce- the University of Pennsyl- nal closely followed the progress ment on February 16 was closely O of the special committee, remind- attended, whether in the room vania, could count on a very atten- tive built-in audience when she ed readers of the Health System’s where the trustees were meeting announced the recommendations $400 million operating losses in or throughout the campus after- of a special committee that had the previous four fiscal years, and ward. been considering the future of set forth various hypothetical sce- Given the circumstances, then, Penn’s Health System. In fact, an narios. In its issue of February 14, the special committee’s recom- observer might have detected a the Inquirer’s coverage began: “By mended “direction” for UPHS palpable tension throughout Friday, the dismantling of the Uni- may have seemed slightly anticli- UPHS in the days just preceding versity of Pennsylvania Health mactic. In some ways, the status Rodin’s announcement. Two System – a network of four hospi- quo was reaffirmed – the Universi- months earlier, in an e-mail memo tals, several walk-in treatment cen- ty, Rodin announced, “is commit- to interested parties, Rodin had ters, and hundreds of doctors’ ted to maintaining an integrated acknowledged the Health System practices assembled over the past health system.” As she put it, was “well on the road to financial decade – could begin.” For its part, although the special committee recovery,” but she also noted that The Daily Pennsylvanian, the inde- “has been mindful of the financial it “carries a very sizable debt bur- pendent undergraduate newspa- imperatives, our first priority has den, a majority of which is con- per, speculated about various been to sustain and enhance the nected to HUP.” The message potential buyers, including The University’s academic and coming from University and Children’s Hospital of Philadel- research missions; continue to be a UPHS administrators had been, as phia. In one of its editorials about first-rate academic medical center one spokesperson put it, that “sim- the Health System’s financial trou- on the cutting edge of education, ply preserving the status quo is bles, the newspaper’s board research, and patient care; and not an option.” That was why likened the situation to “a long, maintain the School of Medicine’s Rodin had charged the special agonizing soap opera.” standing as one of the top medical committee of University trustees In late January, another group schools in the country.” Perhaps and senior medical faculty “to with a particularly strong interest the chief difference is the creation consider options for the future of in the future of the Health System, of the new entity, which Rodin the health system.” the medical faculty, organized a said could take a year or longer to One of the options that had symposium on the current health- set up. The School of Medicine been rumored was outright sale of care market and the challenges would remain with the University, some or all of the four UPHS hos- faced by academic medical cen- as would the faculty practices, pitals and the physician practices ters. Among the speakers was known as CPUP. Although it was in Penn’s primary-care network. In Arthur K. Asbury, M.D., interim too early to give specifics, Rodin reporting the recommendations dean of the School of Medicine, told a group a campus reporters made by the committee on Febru- who took the opportunity to estab- that “we intend to bridge across” ary 16, however, Rodin made clear lish a financial context and report the medical school and the health- that the University trustees “have on strategic planning over the last services component. reached a decision not to sell any decade and a half. (See “The Last Although UPHS currently has of the hospitals in the Health Sys- Word,” inside back cover.) Other its own CEO and its own govern- tem.” She also announced that the topics included the effects of the ing board, the new 501C3 is University would establish a new, sale of an academic medical center expected to be more flexible in the not-for-profit entity (501C3) for the to a not-for-profit or to a for-profit “challenging” marketplace. At pre- Health System, wholly owned by organization. From the questions sent, Rodin said, UPHS needs four the University but with its own and comments made by members budget approvals, which limits CEO and governing board. of the faculty, it seemed clear that how “nimble” and swift it can be For months, rumors about the they found the potential sale of the in making decisions and acting on fate of UPHS had come and gone Health System – particularly to a them. Indeed, as Rodin explained, and sometimes come again. In her for-profit entity – unpalatable. she expects the new entity to be mid-December e-mail message, Then, just a week before Rodin “more aggressive” and more open Rodin felt compelled to deny a made her announcements, Asbury to “potential alliances with strate- rumor that the University trustees and Robert D. Martin, Ph.D., inter- gic partners who share our acade- were about to “sell UPHS hospi- im CEO of the Health System, mic vision.” Among the examples tals to a for-profit health-care orga- released a message acknowledging is the joint development of the for- nization.” The Philadelphia Inquirer “the uncertainty of the past few mer site of Philadelphia’s Civic and the Philadelphia Business Jour- months” and assuring UPHS fac- Center by Penn and CHOP as well

2 PENN MEDICINE as a recent strategic alliance with More honors for Armstrong The John Scott Award, which Siemens Medical Systems, Inc., a was announced in January, is pre- manufacturer of medical diagnos- lay M. Armstrong, M.D., sented by the Board of Directors of tic tools, that is designed to save professor of physiology at the City Trusts of the City of UPHS as much as $16 million over CPenn since 1975, has added Philadelphia. The awards have eight years and set the stage for two more awards to his curriculum been made since 1834, and recipi- innovative and cooperative vitae in the last few months. Arm- ents include Mme. Curie, Thomas research. strong, who shared the 1999 Albert Edison, and Jonas Salk. In the short run, Rodin Lasker Basic Medical Research acknowledged, the new entity Award from the Albert and Mary would not insulate the University Lasker Foundation, received the Stretching neurons to from the heavy debt burden 2000 John Scott Award in January induce growth accrued by the Health System; but and the Gairdner Foundation she expects the new entity to earn International Award for Medical he common wisdom is that better operating margins over time Science in April. Armstrong’s tension is bad for the and eventually to be able to research involves the “gating” Tnerves, but it seems that a restructure its debt. Rodin also process, which opens and closes little applied tension might be mentioned that the financial turn- ion channels, and his work is good for nerve cells. Researchers around made by UPHS over the widely respected for expanding at the Medical Center have been last year — including an operating profit of $18.5 million for the first half of FY2001 — had made it more attractive to organizations looking to acquire or form partner- Leonardi Tommy ships. “The number of interested parties now is very different than it would have been in June of ‘99,” said Rodin. “The cost-cutting mea- sures, the revenue-generating measures, the performance of the Health System clearly made it attractive — and it’s attractive to us, too.” Part of the new direction of the Health System includes a restruc- turing of leadership as well. Instead of seeking a single person to hold the joint position of dean of the medical school and CEO of Douglas H. Smith, M.D., left, and David F. Meaney, Ph.D., are exploring ways to bridge damaged the Health System, the University areas of the nervous system. is now conducting a national search for a dean/executive vice scientific understanding of the able to grow neurons – by stretch- president; the CEO of the new human body’s electrophysiology. ing them. The stretched neurons, entity would have dotted-line Armstrong is one of four scien- they hope, offer a new means of reporting to the dean/EVP. A tists to receive this year’s Gairdner bridging damaged areas of the potential split in leadership of this International Award, which has nervous system. kind was vociferously opposed by been bestowed by the non-profit Using a motorized device to the medical faculty in a meeting foundation annually since 1959. pull connected neurons slowly last spring. This year, Rodin point- Winners are selected in a secret away from each other, the Penn ed out, the faculty was brought ballot by a committee of scientists researchers have discovered that into the deliberative process. In from Canada, the United States the connecting nerve fibers, or addition, she said, after several and the United Kingdom. Of 251 axons, grow longer in response months with Asbury and Martin past recipients, 54 have gone on to to the strain. In addition, the in the two interim roles, “we’ve win the Nobel Prize. The other researchers have grown these had the experience of a split.” She three scientists honored include elongated nerve fibers directly on likened it to “an in vivo experi- Bertil Hille, Ph.D., of the Universi- a dissolvable membrane, ready- ment.” As Rodin put it, “With the ty of Washington, and Roderick made for transplant. right kind of people at the helm, it MacKinnon, M.D., of Rockefeller “Most studies have examined works.” University, who have also worked axon growth in terms of how on ion channels and who shared axons sprout from one neuron and John Shea the Lasker Award with Armstrong. connect to another,” says Douglas

2001/SPRING 3 VitalSigns

H. Smith, M.D., associate professor Smith could find no physiological either side and allowing the nerve of neurosurgery and lead reason why they could not be signal to cross. In fact, it is likely researcher on the project. “But stretched even further. Reporting that researchers would not have to there is an equally important form on the Penn findings, The New York modify the stretched neurons before of axon growth that has been over- Times noted that “No other tech- transplanting, because the body eas- looked, the growth of axons in nique for inducing axons to grow” ily absorbs the membranes used in terms of the growth of the entire across gaps created by injury “has the stretching process. organism. In a way, stretching is produced axons as long and thick “Axons are promiscuous little akin to how nerve cells grow in as Dr. Smith’s” (April 17, 2001). things,” says Smith, “and we’re developing children – as they get “We believe that, as we put pres- counting on their innate tendency taller, their axons get longer.” sure on the axons from either end, to feel around and make new con- Besides Smith, the Penn research the axon begins to add a little to its nections.” team includes David F. Meaney, own internal skeleton in response,” Commenting in The New York Ph.D., associate professor of bio- explains Smith. “It is sort of like the Times on the Penn research, engineering, and John A. Wolf, a little boy who tries to get taller by Edward Wirth, M.D., a neuroscien- graduate student in neuroscience having his siblings pull on his limbs, tist at the University of Florida, who is also a research specialist in only in this case it seems to work.” called the stretching strategy “a the Department of Neurosurgery. During these experiments, Smith fundamentally novel and very ele- Their discovery was published in noticed another curious phenome- gant approach.” the April edition of Tissue Engineer- non. “We began to see that the Smith conceives of using this ing. Their findings, which have stretch-grown neurons could actual- approach for other types of neural evolved from Smith’s continuing ly organize themselves into bundles, injuries that affect long axon tracts, research into how neurons respond nerve fibers of composed of thou- such as optic nerve damage and to their environment, also represent sands of axons, and these bundles peripheral nerve damage. “We are a departure from other methods of gradually consolidated into even only at the beginning of learning restoring neural pathways in spinal- larger tracts.” In theory, these large what we can do with this concept.” cord injuries. One approach has tracts could serve as the bridge been to transplant a synthetic scaf- across damaged tissue, connecting Greg Lester folding across the injured area and then use a trail of attractive chemi- cals to entice axons to grow out Penn scores high in the rankings again from one end of the lesion and con- nect with viable nervous tissue on he University of Pennsylva- four other schools. the other side. While these attempts nia School of Medicine has Penn’s School of Medicine was have had limited success in the lab- Tagain been ranked one of also second in total funding from oratory, they have been hampered the top medical schools in the the National Institutes of Health in live subjects by, among other nation, according to an annual for Fiscal Year 2000. It is the third things, the body’s innate desire to survey of graduate schools con- year in a row that Penn finished stop neuron outgrowth. ducted by U.S. News & World behind only Johns Hopkins in this According to Smith, “Once Report. In the magazine’s April 9th important barometer of research somebody’s nervous system is issue, Penn was ranked fourth strength. Penn’s total funding for already formed, further outgrowth among research-oriented medical research, training, fellowship, and could cause a mass confusion, so schools, the only one in the other grants was $269,936,771. the body actively produces chemi- Delaware Valley named in the top The rest of the top five included cals that stop axon growth.” 40. Ranked ahead of Penn were Washington University in St. But it was the inherent ability of Harvard University, Johns Hop- Louis, the University of California already-connected axons to grow kins University, and Duke Uni- at San Francisco, and Yale Univer- during natural development that versity; Penn was ranked fourth sity. gave the researchers the idea to with Washington University in St. Three of Penn’s departments stretch axons in culture. Smith and Louis. Last year, Penn was ranked were ranked number one in NIH his colleagues began with a group third in the nation. funding: dermatology, radiology of neurons grown in a culture Penn’s School of Medicine was (which includes radiation oncolo- across two membranes. Using a ranked in the top ten in five of the gy), and pathology and laboratory motor that could function in pre- eight specialty programs by deans medicine. Ten more departments cise increments, they separated the and faculty at peer institutions: were ranked in the top five: Bio- two membranes by a few thou- women’s health (3rd), drug/alco- chemistry and Biophysics; Biostatis- sandths of a centimeter every few hol abuse (8th), geriatrics (10th), tics and Epidemiology; Medicine; minutes – a remarkably large dis- internal medicine (6th), and pedi- Neurology; Obstetrics & Gynecolo- tance on the cellular level. Eventu- atrics (3rd). In the annual rankings gy; Ophthalmology; Pharmacology; ally, they were able to stretch the of the top schools for primary Rehabilitation Medicine; Physiolo- neurons an entire centimeter, and care, Penn was ranked 32nd with gy; and Psychiatry.

4 PENN MEDICINE LETTERS dom of choice they have because of in his acceptance speech, paid trib- their lack of debt. ute to his “preceptor,” Dr. Benedict Walter and Anne Gamble are Jones Weatherby. It also stated that HIGH ON HIGH committed to a vision of debt-free Mayock was “the first practicing I am an alumnus of the “late” status for all students at the Univer- urologist in northeastern Pennsylva- Graduate School of Medicine (1952) sity of Pennsylvania School of Medi- nia” and that he “has been chairman and receive Penn Medicine as a perk cine. They have worked tirelessly to of the Department of Urology at for that fact alone. The Fall/Winter help accomplish this goal. Their ini- Mercy Hospital a number of years.” 2000 issue’s cover article by Lisa J. tial gift provided for merit-based According to Lloyd, “There is noth- Bain is great reading because it is scholarships. The subsequent gifts – ing in the 1959 clipping about the great writing and a great subject. and many of those inspired gifts elder Mayock’s medical education Having been a member of the from others – have contributed to other than the reference to his ‘pre- male world for seventy-eight years, need-based scholarships. ceptor.’ This suggests to me that he it does me good to see a male editor Student financial aid remains a may not have attended medical feature in his pages a woman pedia- top priority in all of our fundraising school, but may have been appren- trician/scientist, Katherine A. High, efforts, and we will continue to ticed to medicine (as most American M.D., on a cutting-edge, scientific explore avenues to easing the finan- physicians were prior to the early subject – gene therapy for patients cial burden of our students. With the 20th century reforms in medical with hemophilia. generous support of visionary education).” Is there an Internet address from donors like Walter and Anne Gam- A clipping from 1961 reported which I could download “High ble, Penn medical students will be that the Luzerne County Medical Hopes for Hemophiliacs” for per- able to follow no higher considera- Society also honored Dr. Mayock, sonal use? tion than their heart when deciding claiming that he “established the on their career path. first complete, modern urology Charles Burns Roehrig, department in this county.” As M.D., G.M. ’52 Lloyd points out, the key words in WAS HE FIRST? that phrase are complete and modern, The editor replies: I regret to say but no definition is provided. The that Penn Medicine is not currently Who was first? Continuing your clipping also stated that Dr. Mayock available on the Internet. We are theme of the summer edition of Penn was “the first graduate student in working toward making it accessi- Medicine [whether Penn Med or urology at the University of Pennsyl- ble, perhaps by later this year. Michigan had the first teaching hos- vania in 1912.” Yet Lloyd notes that pital] – I am a graduate of the Uni- the clipping makes no mention of versity of Pennsylvania Graduate the Graduate School of Medicine in A QUESTION OF DISTRIBUTION School [of Medicine], Class of ’47. I 1912; indeed, it was not established worked with Dr. Peter P. Mayock The Gambles [“Priority: Financial until 1916 (and not given the name (uncle of Dr. Robert L. Mayock) for “Graduate School of Medicine” until Aid,” Fall/Winter 2000] could have many years, and he graduated from remained anonymous much more 1919). Lloyd also checked the Uni- the University of Pennsylvania versity catalogs for four years, 1910- easily if they had used their money Graduate School in 1912. He used to to lighten all Penn Med students’ 1914. He searched the lists of med- say he was the first and only student ical students in four separate classifi- debt loads, not just a select few. A and the course was six weeks. When few thousand dollars per year, after cations: post-graduate students in he finished, the images in the cysto- the School of Medicine, all four four years, would have made a big scope were righted, and he stayed difference for me. I would be inter- classes of students in the undergrad- an extra week. He established urolo- uate M.D. program, “special” stu- ested to see any data that the gy in this area as a first-class special- Endowed Scholars chose fields that dents in medicine, and medical stu- ty. I would like to establish whether dents taking courses in public are less remunerative or that they or not Dr. Peter P. Mayock may have practice in underserved areas; I health. No person surnamed May- been the first trained graduate ock appeared in any of the lists in doubt that such a pattern exists, school urologist in the country. judging by the career goals of the any of the four years. Scholars I have met. Charles N. Burns Sr., The only other possibility Lloyd M.D., G.M. ’47, F.A.C.S. raises is that Mayock attended the A Penn Med Alum Kingston, Pa. Medico-Chirurgical College of Philadelphia (which merged with Krista J. Mattox, Associate Executive The editor replies: Mark Frazier Penn in 1916) or the Philadelphia Vice President, Medical Center Develop- Lloyd, director of the University Polyclinic (which merged with Penn ment and Alumni Relations, replies: Archives and Records Center, turned in 1918). The ultimate career paths of the up a news clipping about a testimo- The conclusion? The historical Twenty-First Century Scholars can- nial dinner held in 1959 by the claim for Dr. Mayock cannot be sub- not be analyzed until the students Northeastern Pennsylvania Urologic stantiated from the records at hand. complete their residencies. However, Group in honor of Dr. Peter Paul My thanks to Mark Lloyd for his they all recognize and value the free- Mayock Sr. It stated that Dr. Mayock, diligence.

2001/SPRING 5 A man of manyPART oetry rt unning her

Garret FitzGerald takes his responsibilities as mentor seriously. Here he confers with Dr. Emer M. Smyth, a research associate in the Center for Experimental Therapeutics. Although he shares his name with the man who was prime minist during much of the 1980s, Penn’s Garret FitzGerald has been est international reputation of his own in the fields of medical and p research. And he seems equally adept serving as a scientific me marathon, or recommending a book of poetry.

By Kristine Conner 6 PENN MEDICINE n an essay published in The New York Times last October, actress Chris Chase responded to the news that her brother Paul Greengard had won the Nobel IPrize in Physiology or Medicine. With a tone of amazed befuddlement, Chase looked back on a lifetime of never really understanding what he did, such as apyciencestudying the “thermodynamics of adenylyl cyclase reaction.” But Chase’s break- S through came when she read the newspaper reports on her brother’s award, which finally translated his mysterious discoveries into human terms. She

Tommy Leonardi Tommy learned that her brother’s work related to how brain cells communicate and that one day this research might be used to help people with Parkinson’s and Alzheimer’s disease. This essay stuck with me as I started learning about the work of Garret A. FitzGerald, M.D., chair of Penn’s Department of Pharmacology, director of the Center for Experimental Therapeutics, and Robinette Professor of Cardiovascu- lar Medicine — except instead of adenylyl cyclase, I was encountering terms such as eicosanoids, isoprostanes, and arachidonic acid. (When I mentioned the essay to Dr. FitzGerald during our first meeting, he knew just what I was talking about; it turns out that he has a daily habit of reading The New York Times, The Wall Street Journal, and, as a Dublin native who maintains an interest in Irish sports, politics, science, and literature, The Irish Times on the Web. He jokes that he has not yet been “sufficiently acculturated” to read USA Today.) But I soon found that I would not have to make the mental leap that Chris Chase did to appreciate her brother’s work, for two reasons. First, Garret (he insists on first names) is one of the few scientists who works on the interface between basic and clinical research. Second, FitzGerald was extremely accommodating to my layperson’s perspective. I came to attribute this to what more than one of his colleagues would later describe as his “sense of humanism,” as well as the fact that he doesn’t see the world only through the eyes of a scientist. Given how prolific he is as a researcher – with more than 260 studies published, millions of dollars’ worth of grant money earned, and a wide range of committee and editorial board work – it would appear that he must pursue science with a single-minded intensity. In actuality, he has what Irish col- league Desmond Fitzgerald, M.D. (small “g,” no relation), director of the Centre for Cardiovascular Science at the Royal College of Surgeons in Dublin, described to me in an e-mail as a “frightening knowledge of classics, literature, art, and music” — and, he added, “he’s very funny in an irreverent Irish way” to boot. Garret FitzGerald (or “Big G,” as some of his colleagues fondly nicknamed him some years ago) has an intellectual curiosity that transcends science, and some- how he finds time to satisfy it.

f you’ve ever counseled a patient to take aspirin because of its cardioprotec- tive effects, prescribed one of those recently approved COX-2 inhibitors such Ias Celebrex or Vioxx, or fielded questions from patients about antioxidant vitamins, then you have some familiarity with the questions that Garret FitzGer- ald has been working on. He simplified matters by explaining that he has spent the past 23 years working in one biochemical pathway. “As technology changes, ter of Ireland the precision with which you can get answers changes,” he says, “and the trick tablishing an is to stay focused on a small question.” pharmacological Early in his career, he developed an interest in understanding how the hor- mone-like fatty acids called prostaglandins modify the action of blood cells on ntor, running a the vessel wall, and then how this mechanism underlies the pathophysiology of certain conditions, such as thrombosis and atherosclerosis. (This year, he’s serv- ing as chair of the American Heart Association’s Council on Arteriosclerosis, Thrombosis, and Vascular Biology.)

2001/SPRING 7 Prostaglandins are formed by the action of the cyclooxygenase (or Leonardi Tommy COX) enzyme on arachidonic acid in the cell membranes, FitzGerald explains, and he and his col- leagues have helped to elucidate how these enzymes work. Their studies have contributed to our understanding of why it’s rational to use aspirin, a COX-inhibitor, as a cardioprotective measure; for this work, FitzGerald won the first European Prize for Aspirin Research in 1993. He’s also help- ing to elucidate the mechanisms of COX-2 inhibitors, the so-called “new generation of painkillers,” and how they might best be used. In doing this work, FitzGerald has always blended basic science Another of FitzGerald’s passions is running. On Locust Walk, he is accompanied by Colin D. Funk, Ph.D., cen- with clinical research: “For a long ter, and Daniel J. Rader, M.D., right. time, it didn’t have a name, but translational medicine is what I pharmacology, and the William leagues, in fact, have been collabo- have been doing throughout my Stokes Professor of Experimental rating with him since his days in career.” Upon starting his premed- Therapeutics. What FitzGerald Nashville and Dublin – and even ical studies at University College calls his “homing gene” led him moved across the world to work Dublin in 1968, Garret had his back to Ireland in 1991; he became with him. FitzGerald notes that the sights set on becoming an ortho- chair of the Department of Medi- structure that gives him responsi- dontist, but soon found himself cine and Experimental Therapeu- bility for the two centers and the interested by the research aspects tics at University College Dublin department sends an important of medicine and, more specifically, and director of the Centre for Car- message about aligning the mis- pharmacology. As he recalls, “I diovascular Science. After just sions of scientists in the lab and liked the sciences, and I liked three years, however, his sights physician-researchers who work pharmacology, but what was miss- turned back to the United States, with patients. As he wrote in his ing for me was the clinical exten- not only because he had realized first “chairman’s corner” in the sion.” When he saw a poster for a that this was really his home, but pharmacology department’s day course in clinical pharmacolo- also because he felt that this was a newsletter in the fall of 1996, this gy that was being offered in Lon- better climate for the kind of sci- structure “brings the rigors of don, he decided to attend. The ence he wanted to do. basic science to bear on clinical sci- course excited him about the pos- entists, while it also renders the sibility of doing research with an ince arriving at Penn in 1994 clinical relevance of purely basic eye toward developing therapeutic as founding director of the science projects more tangible.” applications that would help peo- SCenter for Experimental Ther- CET faculty are drawn from the ple. apeutics (CET) and being appoint- departments of Medicine and FitzGerald followed his medical ed chair of the Department of Pharmacology, and the overall studies at University College Pharmacology two years later, vision is to foster research that Dublin with internships at St. Vin- FitzGerald has facilitated the inte- uses drugs as probes of disease cent’s Hospital Dublin, graduate gration of traditionally separate mechanism and develops more work in statistics at Trinity College branches of research into what he sophisticated approaches to dose Dublin and the University of Lon- has always seen as a more produc- finding, based on understanding don, and clinical pharmacology tive model of solving problems the mechanisms of drug action fellowships at the Royal Postgrad- related to human disease. He and exploring individual differ- uate Medical School in London insisted on the word facilitate again ences in drug response. and the Max Planck Institute in and again during our conversa- CET faculty members on both Cologne, Germany. He then spent tions, crediting the many col- sides of the research fence say they the 1980s at Vanderbilt University leagues who have been instrumen- appreciate and benefit from in Nashville, Tennessee, where he tal in the development of CET and FitzGerald’s ability to bridge that eventually became chief of the its relationship with the General divide. “There are not many scien- division of pharmacology, director Clinical Research Center (GCRC) tists who can do both basic and of the training program in clinical housed within HUP. Some col- clinical research, and I like that in

8 PENN MEDICINE him,” says Colin D. Funk, Ph.D. A developing treatments and cures acid. (FitzGerald describes iso- professor of pharmacology, Funk for complex human disease.” prostanes as the “mirror image” of has been at Penn for five years but FitzGerald stresses that he takes the prostaglandins that interested first worked with FitzGerald at the most pride in serving as a role him early in his career.) Over the Vanderbilt. Funk is a basic model for the young scientists past five years, the Penn scientists research scientist who uses gene- who are looking to do both basic have demonstrated that iso- disrupted mouse models to study research and clinical work. “Any prostanes can be measured in the cardiovascular function and program is only as good as the body fluids and tissues of both inflammation. FitzGerald “got me young people in it,” he says. He is animals and humans. Their series going” on atherosclerosis, he also proud of how the six-year-old of studies has shown that iso- recalls, and he admires FitzGer- CET has developed strong cardio- prostane levels are elevated in the ald’s way of seeing into the mech- vascular, cancer, and neurophar- presence of conditions such as anisms of cardiovascular disease. macology research arms, with high cholesterol, atherosclerosis, On the other side is Emma A. pharmacogenetics currently under tobacco and alcohol use, alcohol- Meagher, M.D., an assistant pro- development. Finally, he notes that induced liver disease, and chronic fessor of medicine who serves as the Department of Pharmacology obstructive pulmonary disease. associate director of the Center for has gone from #15 to #2 in NIH The levels are also elevated follow- the Assessment and Treatment of funding, and that CET is now the ing heart bypass surgery or heart Complex Hypertension and as main user of the General Clinical attack treatment during the critical associate director of the Cardio- Research Center. He assigns the period known as reperfusion, vascular Risk Intervention Pro- lion’s share of the credit to the when blood flow is restored to the gram. “Garret’s a master at think- people he works with, while they heart muscle. ing about how we can marry the credit him. Working with Virginia M.-Y. mind of the busy clinician with Says Meagher: “He has a real Lee, Ph.D., and John Q. Tro- that of the researcher in the lab,” gift for bringing people together janowksi, M.D., G.M.E. ’80, Ph.D., she says. Describing herself as “a and bridging disciplines, and this directors of Penn’s Center for Neu- pure clinician” when she first is the key to success.” rodegenerative Disease Research, started working with him in FitzGerald and his colleagues Dublin eleven years ago, she says f fashion has smiled on this recently showed that isoprostane he basically trained her in how to approach to pharmacological levels were elevated in the frontal do research. When she arrived at Iresearch, it also has smiled on and lobal areas of the brains of Penn with him, he encouraged her the antioxidant research done by people who died of Alzheimer’s to use that experience to develop FitzGerald and his colleagues. For disease. All of these studies sug- the new Patient-Oriented Research years now, antioxidant vitamins gest a rational basis for under- Program, which provides formal have been hyped by their manu- standing a range of diseases in opportunities for M.D. and Ph.D. facturers and the media as a terms of the oxidative damage our students to learn the ins and outs weapon in knocking out the oxida- bodies undergo over time — a of clinical research. Meagher is the tive stress that can lead to heart process akin to the rusting of program’s director. disease, cancer, and other illnesses. metal — and applying therapies According to FitzGerald, the We now have millions of healthy accordingly. emphasis on translational medicine people popping vitamins every “A picture is beginning to that the Center for Experimental day, but there has been no rational emerge about the functional rele- Therapeutics embodies is getting scientific basis for such strong vance of oxidative stress,” FitzGer- more and more attention – and faith in antioxidants. Part of the ald notes, “and this opens the door funding. “The dearth of trainees problem is that so-called free radi- for elucidating the clinical phar- with both kinds of expertise has cals — products of normal metab- macology of antioxidants.” Using been recognized,” he says. This olism and of environmental expo- isoprostanes as a biochemical was the subject of an editorial last sures such as alcohol and tobacco, marker of this stress has the poten- March in The Boston Globe, written which bind to healthy cells and tial for allowing us to make ratio- by a researcher at Massachusetts cause what’s known as oxidative nal, targeted use of antioxidant General Hospital and a Harvard damage — are extremely evanes- vitamins, instead of assuming that professor of clinical medicine. “In cent. It was difficult to measure they are always good for all peo- our excitement about the progress the damage associated with them. ple. A mouse model has already of science,” they wrote, “we cannot FitzGerald and his colleagues at shown that the antioxidant action forget that determining the DNA CET — including Meagher, Daniel of Vitamin E, as tracked through sequence of a gene, or understand- J. Rader, M.D., and Domenico isoprostane levels, significantly ing how two proteins bind to each Praticò, M.D. — have been study- reduced atherosclerotic damage to other in a test tube, or learning ing isoprostanes, which are bio- cardiovascular tissues. “Before you how a particular type of cell grows chemical markers produced when can perform rational clinical trials, in a petri dish, is not equivalent to free radicals attack arachidonic you have to have a benchmark,”

2001/SPRING 9 FitzGerald often says FitzGerald, and now this emphasizes the FitzGerald says that he remains benchmark can be used to evalu- collaborative nature very interested in seeing his home ate the use of antioxidants in country become more of a research humans. The day may come when of his work: “Art is leader and is “very much engaged physicians can measure a patient’s I; science is we”. with what’s going on there.” Still, level of oxidative damage through he appreciates the “happy synthe- a simple urine test and then make sis of crisis and opportunity” that appropriate recommendations led him back across the Atlantic to about antioxidant therapy. Penn.

itzGerald’s other work in this speak in general terms about the itzGerald has an incredible same biochemical pathway importance of the independently capacity for being in many Fhas led to many discoveries funded academic research system Fdifferent places, both physi- with important therapeutic impli- as a check on industry — a system cations — some well-received, that ensured his freedom to raise some not so well-received. He says questions about already-approved that he did “a piece of the work” medications that seemed to guar- on understanding the cardiopro- antee huge profits. tective benefits of aspirin, helping “In academia, we’re only to show how it inhibits the responsible to the public health cyclooxygenase enzyme that con- and telling the truth as we see it, verts arachidonic acid into telling the bad news as well as the prostaglandins. His interest in this good news,” he says. “The phar- area continues, and recently he maceutical industry is wonderful and Francesca Catella-Lawson, in terms of innovation, but it’s a M.D., who has since left Penn, business, and that’s always a big published a study showing that constraint.” The interface between taking Ibuprofen before aspirin industry and academia is essential could actually interfere with its and “90% productive,” he says, cardioprotective effects. Two years but those who choose to work in ago, FitzGerald’s lab was the the latter have to maintain an source of an important finding independent point of view. NIH about so-called super aspirins, funding, he believes, is what guar- COX-2 inhibitors such as G. D. antees that independence. Searle’s Celebrex (celecoxib)and A decade ago, FitzGerald tried Merck’s Vioxx (rofecoxib), now to replicate this publicly funded being used by millions of people academic research structure in his FitzGerald is as much at home among books as he is in with osteoarthritis and rheumatoid home country. But as chair of the a laboratory. arthritis. Department of Medicine at Univer- In a study of celecoxib funded sity College Dublin and Mater cally and mentally, in rapid suc- by Searle, FitzGerald found that it Hospital, he faced what he calls cession. The first time I met with suppresses prostacyclin, a hor- “strong personal resistance” from him last fall, he had just returned mone-like substance produced in physicians who did not want him from a series of scientific meetings the walls of blood vessels that acts to impose an American-style acad- in Japan, a weekend in Chicago for to dilate the vessels and inhibit emic structure on the hospital. his son’s wedding, a lecture at the platelet aggregation, or clotting. Soon he came to realize that politi- Royal College of Surgeons in Lon- This discovery raised a red flag cal struggles would consume most don, and a meeting at a Stamford, that Celebrex and other COX-2 of his time. Nevertheless, he and Conn., biotechnology company on inhibitors might increase the colleague Desmond Fitzgerald whose board he sits. He was also potential for heart attacks and were able to establish the Centre getting ready to run the New York strokes in groups at higher risk. I for Cardiovascular Science, which City Marathon (which he finished asked Garret if he had experienced is now thriving at the Royal Col- at a very respectable 3:38:40). When any backlash from these pharma- lege of Surgeons in Dublin. In an e- we last met before the winter ceutical giants after the findings mail, Desmond Fitzgerald told me break, FitzGerald had just finished were published in the January that Garret, who serves as advisor a whirlwind tour through Europe, 1999 Proceedings of the National to the Irish government, deserves with stops in Berlin, Paris, Rome, Academy of Science and promptly credit for the increasing amounts and Lisbon, for activities ranging picked up by the news media. of public money now being poured from serving on an international While he would not discuss the into research there (billions now awards committee meeting to specifics of the situation, he would instead of millions). Garret delivering the keynote address at

10 PENN MEDICINE the European Cardiac Society. He him to Penn in 1994. “Some princi- slagging with.” (A quick “Google” also made a stopover in Dublin to pal investigators want to control search reveals the following defini- have dinner with his parents. your work,” he recalls, “but Garret tion of slagging: “the delicate art of “This is a global game, and you gave me the freedom to use my teasing someone in such a fashion have to be out there participating,” own brain. He’s open-minded, he that they look forward to it; prac- FitzGerald says. Running provides discusses things, but then he lets ticed widely throughout Ireland the perfect way for him to get out you take it from there.” When by all manner of people.”) and see his surroundings when FitzGerald offered him the oppor- Perhaps what colleagues view he’s on the road — and to stay in tunity to continue working with as FitzGerald’s sense of humanism shape for marathons. him at Penn, Praticò says, he did derives from the fact that he has so On top of all this, he manages not hesitate. Emma Meagher has a many interests besides science. to act as an effective mentor to the similar take on FitzGerald’s skills He’s an avid reader of novels, his- young scientists in his lab and as a as a mentor. In developing the tories, and biographies, and he has Patient-Oriented Research Pro- vast stores of cultural, historical, gram, she says, “He gave me con- and literary knowledge on which structive input, but he let me make to draw. His chairman’s columns the decisions and figure out what in the department newsletter quote was most appropriate. I think he’s authors as diverse as Shakespeare, Tommy Leonardi Tommy a master at identifying someone’s the Czech novelist Milan Kundera, potential as raw material and then the Irish poet Seamus Heaney, and providing them with the where- Henry Wadsworth Longfellow. It’s withal to realize that potential.” clear that reading is an automatic And this is what FitzGerald part of his life, and he says he is says he enjoys most: working with disappointed when he asks med- the next generation of scientists, ical school applicants what they’re showing them what’s possible, reading and “95 percent of them and building their confidence. don’t have an answer.” “I’m not a blue-ribbon scientist; I Garret also runs about 20 miles won’t win the Nobel Prize,” he a week, stepping up his training says. “My joy is watching the evo- just before a marathon — not the lution and achievement of people best way to train, he admits, but as who work with me. They are your much as he has time for. Given his legacy; and you live for their philosophy of science, it’s not sur- achievements.” Again, he empha- prising that he derives “a collec- sizes the collaborative nature of tive sense of accomplishment” his work: “Art is I; science is we.” from long-distance running. FitzGerald shares a laugh with John A. Lawson, a labora- Research associates Peter “Unless you are from the high- tory director in the Center for Experimental Therapeutics. McNamara, Ph.D., and Emer lands of Kenya,” he says with a Smyth, Ph.D., both of whom hail laugh, “you’re really only compet- sounding board for his colleagues, from Ireland and have been work- ing with yourself. There’s no one and he makes it a point to be ing in FitzGerald’s lab for a few you want to lose; you’re all in it available electronically if he’s not years, say they’re amazed at the together.” available in person. (In one of his amount of confidence he has in He’s also tuned into the needs chairman’s columns for the them. “With Garret, nothing is and interests of the people who department newsletter, he refers to impossible,” McNamara says. “He surround him. So it should not “the umbilical features of this makes me feel like I could be the have surprised me to receive this portable computer which guaran- head of the National Academy of e-mail a few weeks after our last tee a narcotic connectivity with Sciences or the head of a biotech- meeting, a follow-up to a question Philadelphia.”) For FitzGerald, the nology company, if I wanted to I had asked him about his favorite core pleasure of science lies in col- be.” And both say they appreciate writers: “I do have a woman laboration and friendship, and his accessibility on a personal writer to recommend to you; my he’s worked hard to create a level. McNamara remembers talk- favourite of all time, in fact, whom research environment that is as ing World Cup Soccer with Garret I forgot about when you asked me free as possible from what he calls instead of science during their first the question. Marguerite Yource- “competitive anxiety.” meeting. Now they have a tradi- nar – try Memoirs of Hadrian for a Domenico Praticò, M.D., tion of watching the Six Nations kickoff, her masterpiece.” research assistant professor of Rugby Tournament at the Dickens pharmacology, started working Inn in Philadelphia’s Old City. Kristine Conner, a free-lance writer in Bala Cynwyd, Pa., is the author of “The Many Lives with FitzGerald as a postdoctoral Smyth says that Garret is the kind of Asthma” (Penn Medicine, Summer 2000). fellow in 1992 and then followed of person you can have “good fun

2001/SPRING 11 n West Philadelphia,

Tommy Leonardi Tommy I Penn medical students run and staff two clinics, which offer “a chance to help people” and an opportunity to gain valuable experience working with patients.

Jessica Haffajee, a first-year student, takes Delano Cooper’s medical history at the UCHC medical clinic. By Marie Gehret CLINICAL CARE

tanding at the back of a makeshift auditorium in the that would be serving hospitality dinners on Christmas Day. basement of the St. Agatha-St. James Catholic Across the room, five Penn medical students readied SChurch at 38th and Chestnut streets, Lee Ann Draud the UCHC medical clinic for business: They unloaded signaled to get the congregation’s attention. Her voice patient files and medical supplies; placed ward curtains competed with the clanking of food trays, the din of and two wooden chairs at each of five exam stations; light-hearted conversation and intermittent guffaws, and stocked the reception desk with a sign-in sheet and the bustle of twenty-somethings setting up equipment on dozens of health-promotion pamphlets; and placed color- stage. She introduced herself as the meal coordinator for ing books and crayons on a waiting-area table to occupy the University City Hospitality Coalition, a nonprofit the children of patients. organization that has provided homeless and underprivi- The UCHC medical clinic operates Wednesday nights leged members of the West Philadelphia community with in conjunction with the soup kitchen and under the aus- hot meals and social services since 1986. pices of Penn’s School of Medicine, offering free acute Nearly a hundred men, women, and children seeking care, physicals, vitamins, seasonal flu shots, periodic TB warmth and nourishment turned out on this night — the screenings, educational materials, and referral services to Wednesday before Christmas — as the piercing cold had patients in need. The clinic was established by Penn Med forced the city to declare a “code blue.” Draud welcomed students in 1991 and continues to be run and staffed her guests as they ate, then ran down a list of nearby places almost entirely by students. A faculty adviser is required

12 PENN MEDICINE Tommy Leonardi Tommy

At the UCC clinic, first-year student Emily Snyder takes Sonya Dove’s blood pressure. CLINICAL CARE

to serve as a preceptor, and a licensed HUP pharmacist with the student to render a diagnosis and treatment dispenses a small formulary of medications such as plan. antibiotics, decongestants, Ibuprofen, and ointments. “Students get seasoned pretty quickly,” says W. Richey Midway through the meal, Kitty O’Hare, a second-year Neuman, M.D., M.P.H., the medical director of the clinic medical student at Penn, announced that the clinic was and one of 15 faculty preceptors. “At first, many of them open and encouraged the diners to seek medical attention, are taken aback. But in a few months, they become veter- particularly since the clinic would be closed the last ans.” Wednesday of December. Her appeal immediately drew Neuman, who is also an assistant professor of medicine eight men from the cafeteria-style tables; a handful of and a physician at the Penn Center for Primary Care, is stragglers gradually got in line. Some had been there seasoned himself. He has done volunteer work locally before. Some had even amassed thick files and developed since his 1997 arrival in Philadelphia and has been a good rapport with the medical staff. involved in treating homeless people since his residency One by one, patients were seated at an exam station at Oregon Health Sciences University. In the early ’90s and then seen by the student assigned to him. Initially, there, he established a clinic for the homeless and later did the student took the patient’s medical history, determined the same at Yale University, where he took his fellowship. the chief complaint, and performed a physical. Then the He admits he occasionally “raided the medical supply attending faculty adviser stepped in and collaborated closets” in order to support his cause.

2001/SPRING 13 hile times have changed month, when money runs a little for Neuman (who runs short, more people turn out for the Leonardi Tommy Wthe UCHC clinic entirely meal, and therefore, the clinic. They aboveboard), he hasn’t lost touch are coming first and foremost for with the student perspective. “I the meal,” he explains, “so if we think a lot of the students feel that can get them in for that, we can this [volunteering] is a part of the treat them while they’re here.” humanistic mission of medicine,” he says. wide variety of cases pre- That seems true in large part, sent at the clinic: sore but O’Hare, for example, entered A throats, colds, rashes, sores Penn Med with the intention of — what Neuman calls the “bread continuing the charitable work she and butter complaints.” Sometimes, had begun at her alma mater, the a patient may come in because a College of the Holy Cross in limb hurts, and it turns out to be Worcester, Mass. “One motto of my gangrene. Another person may college, and of the Jesuit order that have an infection from sutures that runs the college, is ‘Men and were administered in an ER but Women for Others’— the idea that never removed because he lacked service to others is part of our call- insurance or continuity of care. David Jackson, seated, was Stefan Zimmerman’s first-ever ing as human beings,” she says. About half the cases are related director of the UCHC clinic, right, gives Zimmerman some “My faith does influence my sense to dental pain or dental problems of social justice, which tells me that that have resulted from a lack of preventive care, adds Susan E. Health promotion and information are important parts of helping others is part of my role in Sonya Dove to some relevant brochures. life.” Wiegers, M.D., an assistant profes- According to Michael Tracy, a sor of medicine who was the clin- second-year student who was fin- ic’s medical director for more than seven years. Although Penn’s den-

ishing his term as a student coordi- Leonardi Tommy nator, most of the medical students tal school conducts its own clinic at volunteer because, simply put, it UCHC from time to time, “it’s usu- gives them “a chance to help peo- ally extraction or nothing,” Wiegers ple.” says, “and many people don’t want And that it does. tooth extraction, especially in the As Marla R. Davis sees it, access front of their mouths.” to free health care in the city is a Other patients have more chron- vitally important way to “fill the ic problems like high blood pres- gaps” between the uninsured and sure, diabetes, and asthma, or insured, between the poor and emergencies such as chest pains privileged, between the sick and and shortness of breath. The clinic healthy. Davis is director of the is not equipped to handle those University of Pennsylvania Health types of cases, nor can it afford to. System’s Office of Community (Its budget is in the low thousands, Affairs, which serves as a liaison and it subsists on a Philadelphia between medical students, commu- Foundation grant, student-spon- nity leaders, and UPHS administra- sored glove sales, and faculty fund- tors. She notes that Philadelphia raisers.) has seen a “dramatic increase” in Therein lies Wiegers’s biggest the number of uninsured residents frustration: the limitations of a free over the last few years. West clinic that can’t provide long-term Philadelphia, in particular, records and preventive care. As a result, high rates of poverty (one in five Wiegers, the associate director of people), and it is associated with non-invasive imaging at HUP, has disproportionately high rates of founded a sister hypertension clinic infant mortality and cardiovascular that will meet alongside the UCHC deaths. medical clinic a couple of times a On any given Wednesday, five to month. The new clinic is funded by 10 patients visit the UCHC clinic. a grant from the Edna G. Kynett “It varies,” says Tracy, who proudly Foundation. points out that the clinic was open As a preceptor — and a physi- a record 51 weeks during his tenure cian dedicated to serving the poor last year. “Toward the end of the — Wiegers impresses upon her stu-

14 PENN MEDICINE dents that “medical problems vary nother sizable contingent by socioeconomic bracket.” She of Penn medical students is says, “Since there is no city hospital A seeking pre-clerkship expe- in Philadelphia, there’s perhaps no rience about two miles northwest other way that they [students] of Penn’s campus, at the United could experience this.” Community Clinics. This free clinic, Tracy agrees that the clinic — a which is also affiliated with Penn, soberingly realistic training ground meets Mondays from 6:00 to 8:00 — enhances a medical student’s p.m. at the First African Presbyter- education. “Since most of the ian Church at 4159 Girard Ave. patients are from West Philly, the The United Community Clinics students are exposed to a popula- actually developed as a spinoff of tion that they might not see in a UCHC. In 1995, Penn medical stu- formal clinical clerkship.” dents Rachel M. Werner, M.D. ’98, For O’Hare, the clinical experi- and Liza G. Presser, M.D. ’98, who ence has been valuable on many had participated in the Philadelphia levels. “You learn skills here that Bridging the Gaps Consortium, you wouldn’t [learn] in your first teamed up with Eric W. Fleeger, year or the beginning of the second M.D. ’99, who had volunteered at year,” she says with enthusiasm. Habitat for Humanity in West patient. W. Richey Neuman, M.D., M.P.H., medical pointers. “The faculty really let us do things Philadelphia. The trio conceived of on our own so that we can hone a clinic that would expand upon our physical exam skills, learn how UCHC by incorporating a more what the UCC clinic offers. Here, Emily Snyder directs to take blood pressure properly, multidisciplinary approach to care. and practice things like looking in The students submitted a pro- ears and listening to the heart.” posal to the School of Medicine and “It is a useful skill to learn to enlisted Penn’s schools of Nursing, approach people who are different Dental Medicine, and Social Work from you,” she adds. “We are as well. Once the clinic was working with people who have approved, a lot of work still had to HIV, STDs, addiction, suicidal [pro- be done: fund-raising, drumming files]—people you wouldn’t typi- up volunteers, and finding a home. cally see at an academic medical In fact, locating a suitable site was facility. And it gives us the oppor- actually one of the trickier steps in tunity of seeing how the health- the process, because a facility must care system really works and who’s carry liability insurance in order to left out of it.” house a medical clinic. Marla Davis At the same time, she admits and the Office of Community that volunteering at the clinic can Affairs — as well as Rev. Ed be emotionally draining: “The Pinkney, then the pastor of First patients trust us, but we’re only African Presbyterian Church — here for them once a week. It’s were instrumental in closing the especially hard seeing the children. deal. A sister church, Bryn Mawr I mean, I’m glad that they come in, Presbyterian, awarded UCC a gen- but it’s difficult knowing that they erous start-up grant and continues have to have dinner in a soup to be a financial supporter. kitchen.” Since opening officially in the After spending more than 18 fall of 1996, UCC has treated hun- months at UCHC as a student coor- dreds of patients in the East Park- dinator and community liaison, side section of West Philadelphia. O’Hare completed her stint in Janu- But perhaps the term “treat” is mis- ary, when a new group of first-year leading. None of the UCC clinics — medical students took over. O’Hare medical, nursing, dental, or social and her classmates were responsi- work — is designed to provide ble for soliciting and training the hands-on care. Instead, with stu- new recruits. dents at the helm and a variety of “There has been huge [student] resources at their fingertips, the interest this year,” Neuman reports. UCC clinics aim to point people in There are about 10 to 15 coordinators the right direction. and 20 to 30 other students who are “We try to hook people into the involved in the clinic peripherally. health and social-services systems

2001/SPRING 15 in the city,” says Neal Lischner, a informality that is very much true third-year medical student who has to its locale: UCC operates out of Leonardi Tommy been a volunteer since 1999. “A Fellowship Hall in the church’s patient may be here for a physical, basement. A piano, a miniature but during the screening process, stage, an American flag, brightly we find out that they have housing colored bulletin boards, and a near- problems or they haven’t seen a by kitchen reveal the hall’s more dentist in years.” Drawing on its common function as a reception multidisciplinary approach to help- area and rehearsal room. But on ing the whole patient, UCC refers Monday nights, the hall is trans- within first, then provides entrée to formed: An intake area is set up for city-wide services. patients to check in; four rows of What appealed most to Dave folding chairs form a waiting area; Cowan about UCC was its commit- and ward curtains arranged in a ment to holistic care. “I heard about circle make up exam rooms. A long the clinics when I interviewed with wooden table in the front of the Penn,” says the second-year med- room displays complimentary ical student, “and was really excit- brochures and vitamin packets; a ed about the opportunity to work rarely opened box of pharmaceuti- with students from other schools to cals filled with prescription and provide health-related services to O.T.C. drugs is locked away in the folks in the West Philadelphia com- back. munity.” He adds that his wife was First- and second-year medical Ronald B. Barg, M.D. ’80, here taking Sonya Dove’s vital a graduate student in social work students run the clinic, although at the time and started volunteer- more advanced students often ing with him. Cowan joined UCC return to help. As with UCHC, the in 1999 and went on to become one changing of the guard occurs in of its medical clinic coordinators. January. One faculty member is Tommy Leonardi Tommy The UCC medical clinic can required to serve as preceptor for aptly be described as a “well” clin- the group of five to 10 students ic, and the majority of its patients each week. According to Bream, (between two and 16 a night) are there are three permanent precep- there for well visits, blood pressure tors and about 15 to 20 “part- and diabetes screenings, and physi- timers” who volunteer during the cals for athletic teams or driver’s year. license exams. Just recently, the clinic added flu shots and TB ream acknowledges that he is screenings to its list of services. “very demanding” of the stu- As Kent Bream, M.D., the UCC Bdents. He wants them to stick faculty adviser, emphasizes, “Our their necks out, to use their goal isn’t to practice medicine.” instincts, and to be confident when Bream, an instructor and physician they practice rudimentary skills in Penn’s Department of Family such as taking a pulse or interpret- Practice and Community Medicine, ing a blood-pressure reading. explains: “We are not there to diag- “Medical students inherently know nose and treat pneumonia, for how to do certain things, but they example. We are there to provide have a lack of confidence,” he says. care and to make referrals when “I want them to stop being afraid necessary.” of being wrong and say what they Bream notes that most patients think.” who pass through UCC are Teaching the students how to Under Richey Neuman’s watchful eye, first-year student Brian insured. They use the clinic not for touch and talk to patients is a pri- health maintenance but for supple- mary goal of the medical clinic. In standing can bring down those mental care when they have a cold Bream’s view, the students admit- walls. or need a checkup. For people in ted to Penn Med “are selected for With proper guidance, students the community, the clinic is appeal- their book skills, not their personal- can indeed learn a great deal about ing because of its location, evening ities,” which means that their edu- their patients and themselves. “I hours, short waiting time, friendly cational — and socioeconomic — had one patient who didn’t believe staff, and an environment that does backgrounds could create barriers in Western medicine and who was not look “institutional.” between them and their patients. only at UCC because he needed a Indeed, the clinic has a charming Bream believes that mutual under- physical form filled out,” recalls

16 PENN MEDICINE completely different.” health clinics that consistently Sometimes Bream even engages draws a large patient volume. the students in spontaneous role- More patients means more expe- playing in order to prepare them rience for the students. Extensive for potential patient encounters. In patient contact is, after all, the best particular, the topic of sex educa- way for the student volunteers to tion turns many students “beet grow and learn and become more red,” he says. But it is a medical self-assured doctors. As a first-year reality they can’t avoid. student, Nadia L. Dowshen was “I interviewed a woman who “definitely nervous” during her was HIV-positive and whose long- first patient encounter. “I have term lesbian partner had just died,” taken histories before and am com- Curley recounts. “It reminded me fortable talking to patients,” she that you really don’t know any- says, “but trying to do that and thing about a person just by look- take blood pressure and listen to ing at them and that you should the patient’s heart with little experi- never assume anything.” ence [simultaneously] was a little Last June, an HIV counselor overwhelming. I’m getting more from Philadelphia Health Alterna- comfortable now.” Dowshen, one tives was brought on site to edu- of UCC’s co-coordinators, strives to cate patients about safe sex and offer more community health serv- sexually transmitted diseases, to ices, including childhood immu- signs, is one of the faculty preceptors at UCC. provide condoms and referral serv- nizations, and more education on ices, and to offer HIV testing. issues such as injury prevention Sometimes patients with high-risk and sexual health. As a Penn factors are referred via the medical undergraduate, she founded and clinic; other times, people seek out coordinated school-based health the counseling on their own. Offer- programs at Turner Middle School ing sexual counseling at a church is and University City High School. a rather progressive step. (Most Speaking about the medical stu- Catholic churches, for example, dents, Bream says, “I love to watch refuse to distribute contraception them improve over time. I may be on their grounds.) “The church biased, but I believe that our stu- here has been very active in sup- dents who go through UCC do bet- porting the clinic,” says Autumn ter in or work more comfortably in Grice, a second-year social work clinical clerkships than those who student at Penn who jumped at the haven’t. Of course, I have no real chance to work at UCC a year ago proof of that.” because of its interdisciplinary One of his veterans, Neal Lischner, component. “I think African-Amer- agrees: “I definitely felt more com- ican churches are most in tune to fortable in the hospital [clinics] what the community’s needs are.” than I would have otherwise.” The community, in turn, has For Dave Cowan, UCC is benefi- responded well to UCC. It took a cial for another reason. “It provides while for the clinic to gain the trust many lessons about the value of of its neighbors; however, recent service,” he says. “Because we are quality-assurance surveys indicate so busy, and medical school is at that the clinic is on the right track. times so demanding, it is easy, in Patient visits have steadily the midst of studying for exams increased from less than 100 in and memorizing minutiae, to lose Callaghan, right, auscultates Albert Fountain at UCHC. 1996 to more than 600 in 2000. Like sight of why you came to school the students themselves, the and why you chose medicine as a Christine Curley, a second-year patients seem to learn from their profession. Working at the clinic medical student who has been a UCC experiences as well, and they lets you experience firsthand the volunteer for more than a year. “It are generally good-natured about true potential that the health pro- was an incredibly interesting inter- participating in the students’ med- fessional has to positively impact view because most patients you see ical education. UCC has also people’s lives.” in the hospital believe that Western received a fair number of referrals medicine works — that’s why from District Health Center No. 4 Marie Gehret wrote about Janet L. Abrahm, M.D., they’re there — so it was great to (located at 44th Street and Haver- in the Fall 1999 issue of Penn Medicine. talk with someone whose view was ford Avenue), one of the city’s free

2001/SPRING 17 THE FIRST TURNS 250

Above: Dr. Benjamin Rush, on the staff of Pennsylvania Hospital from 1783 to 1813, was a medical teacher, social reformer, and signer of the Declaration of Indepen- dence. He was known also as a father of American psychiatry. The painting is by Thomas Sully. Top Right: The first surgical amphitheater in American medicine opened in 1804. In use until 1868, it became well known as the site of many operations performed and lectures given by Dr. Philip Syng Physick. Bottom Right: The medical library, begun in 1762, was used by physicians and students. In 1847, the American Medical Association designated it as the country’s most important medical library.

18 PENN MEDICINE his year, Pennsylvania Hospital, the oldest hospital in the United States, celebrates its 250th anniversary, and for Tmuch of that time, the histories of the hospital and of Penn’s School of Medicine have been closely intertwined. Thomas Bond, one of the two founders of the hospital, has been called the nation’s “father of clinical medicine,” because in 1766 he initiated clinical instruction for Penn’s medical students by taking them to the wards of the hospital. The other chief founder of Pennsylvania Hospital, Benjamin Franklin, is well The East Wing of the Pine Building, on Pine Street, has been in continuous use since 1755; its center section known for his role in founding what eventually became the opened in 1804. University of Pennsylvania. Benjamin Rush became the first The nation’s first hospital apothecary (1752) was located in professor of chemistry at the School of Medicine in 1769 – in a small building next to the East Wing. When the Center fact, he held the first chair in chemistry in the nation. In 1783, Building opened, the apothecary moved to the first floor of the new building. Rush joined the staff of the Pennsylvania Hospital, where he became known for his advanced and humane treatment of the mentally ill. Another physician who figured prominently in the histories of both the School of Medicine and Pennsylvania Hospital was Philip Syng Physick. A surgeon, Physick originated the stom- ach pump at Pennsylvania Hospital in 1812. In Innovation and Tradition, one of the histories of the School of Medicine, he is said to have “joined Benjamin Rush as one of the first of the New World physicians to gain a reputation among his Euro- pean counterparts.” John Redman Coxe, a Penn professor of chemistry and later of materia medica, is credited with per- forming the first smallpox vaccination in Philadelphia – at Pennsylvania Hospital. During an outbreak of typhoid fever in Philadelphia in the 1830s, William Wood Gerhard, a Penn doc- tor of physic and alumnus of the school, brought his skills as a clinician and pathologist to bear on the confusion between typhoid fever and typhus. According to Two Centuries of Medi- cine, “Gerhard, intensely applying at the bedside and in the postmortem room of the Pennsylvania Hospital the principles he had learned in Paris, clearly distinguished the two dis- eases.” A ward photographed in the 1890s. Given these and many other ties, it is no wonder that when Pennsylvania Hospital officially became part of the University of Pennsylvania Health System in 1997, leaders of both institu- tions underscored their shared histories. William N. Kelley, M.D., then the dean of the School of Medicine and CEO of the Health System, even joked that Pennsylvania Hospital “has the same portraits we have” in its gallery. Over the years, many Penn faculty members have practiced at Pennsylvania Hospi- tal, and many students and residents have gained valuable experience there as well. Until the University of Pennsylvania moved to West Philadelphia in the 1870s, Pennsylvania Hospi- tal was the most important clinical teaching site for the School of Medicine. Here we offer a brief salute to one of the few American medical institutions that can rightly claim to be older than the School of Medicine.

2001/SPRING 19 AlumniNews

Progress Notes Theodore L. Phillips, M.D. Jeffry J. Andresen, M.D. ’64, president of the Pennsylvania ’59, chair of radiation oncolo- Dallas, professor of psychia- Society of Anesthesiologists. Send Your Progress Notes to: gy at the University of Cali- try at the University of Texas Office of Medical Alumni Relations fornia at San Francisco, Southwestern Medical Cen- Gloria A. Bachmann, M.D. University of Pennsylvania received the first Giulio ter, received the 2000 Edith ’74, G.M.E. ’78, chief of the Medical Center D’Angio Chemoradiation Sabshin Teaching Award obstetrics and gynecology 3535 Market Street Award last fall. Created by from the American Psychoan- service and director of the Suite 750 the Sequoia Regional Cancer alytic Association at its annu- Women’s Wellness and Philadelphia, PA 19104-3309 Center and the ChemoRadia- al meeting. Healthcare Connection at tion Summit 2000, the award Robert Wood Johnson Uni- recognizes an oncologist who Richard W. Besdine, M.D. versity Hospital, in New has made significant contri- ’65, was appointed director of Brunswick, N.J., received the ’s butions to the science of the Center for Gerontology Robert Wood Johnson Uni- chemoradiation. Phillips has and Health Care Research at versity Hospital Award of 40 published on radiation pro- Brown University. The first Honor last May. According to G. Denman Hammond, M.D. tectors and sensitizers, neu- David S. Greer, M.D., Profes- the awards program, Bach- ’48, associate vice president of trons and heavy-particle sor of Geriatric Medicine at mann’s “commitment to health affairs at the Keck beam therapies, hyperther- Brown Medical School, he is women’s health issues and School of Medicine at the Uni- mia and radiobiology, radia- also director of the division empowering women to make versity of Southern California, tion-induced pathology, and of geriatrics at Rhode Island informed decisions regarding was chosen as the United normal-tissue tolerance. Hospital and the Miriam their health care has been States “Cancer Fighter of the D’Angio, the award’s name- Hospital. instrumental in the develop- Year” for 2000 by the Beck- sake, is emeritus professor of ment and success of the strand Cancer Foundation. radiation oncology at the Mary Ferry Cunnane, M.D., Women’s Wellness and University of Pennsylvania. G.M.E. ’69, has joined the divi- Healthcare Connection at the sion of surgical pathology at hospital.” She is a professor ’s James C. Thompson, M.D., Thomas Jefferson University of obstetrics and gynecology 50 G.M.E. ’59, professor of Hospital. and professor of medicine at surgery at the University of UMDNJ-Robert Wood John- Frank J. Tornetta, M.D., Texas Medical Branch at son Medical School. G.M.E. ’50, a Norristown, Pa., Galveston, was elected to the ’s anesthesiologist, founded the Institute of Medicine of the Verdi J. DiSesa, M.D. ’76, a Frank J. Tornetta School of National Academy of Sciences. 70 Chicago cardiologist, was Anesthesia in 1951. Last fall, the John G. Brehm, M.D. ’70, has named to a committee that school, based at Montgomery a new position as medical evaluates candidates for the Hospital, and La Salle Universi- ’s director for the West Virginia Heart of Chicago Award. The ty were awarded a three-year Medical Institute in new award was established federal grant of nearly $1 mil- 60 Charleston, W.Va. The peer- by the American Heart Com- lion to educate certified regis- Newell Fischer, M.D. ’61, review organization for West mittee and Pfizer, Inc., to tered nurse anesthetists who Bryn Mawr, Pa., is president- Virginia and Delaware, the honor the Chicago health- will work in urban and med- elect of the American Psycho- institute also holds numerous care professional who has ically underserved areas. La analytic Association. In contracts for utilization championed the cause of car- Salle started its master’s degree December, he published a let- review and management of diovascular health in his or program in nurse anesthesia in ter in The New York Times in Medicaid programs in West her community. A cardiac 1999 through a partnership support of medical privacy Virginia and Virginia. It does surgeon at Rush-Presbyter- with the Tornetta School. In the regulations proposed by Pres- research into quality issues in ian-St. Luke’s Medical Center, 1970s, Tornetta helped develop ident Clinton. Fischer is a North Carolina and into long- DiSesa is also the Mary and Innovar, an intravenous anes- clinical professor of psychia- term care for Federal govern- John Bent Professor and thesia drug, along with Jansen try at the University of Penn- ment agencies. With a nation- Chairman of the Department Pharmaceuticals. sylvania Medical Center. wide corps of 70 abstractors of Cardiovascular-Thoracic and chart review specialists, Surgery and professor of Antonio R. Silva, M.D. ’57, Barry Goldberg, M.D. ’63, the institute also holds the internal medicine at Rush has been appointed dean of director of diagnostic ultra- contract for the External Peer Medical College. He is cur- the Graduate School of Public sound at Thomas Jefferson Review Program for the Vet- rent president of the Metro Health at the Medical Sci- University Hospital, has erans Administration. Chicago Division of the ences Campus of the Univer- received a program grant from Brehm’s e-mail address at American Heart Association. sity of Puerto Rico. Most the Radiological Society of work is [email protected]. recently, after three decades North America to train African James A. Hoxie, M.D. ’76, in private practice as an physicians in the use of the Edward H. Dench Jr., M.D. professor of medicine at Penn obstetrician-gynecologist, he latest ultrasound technology. ’72, G.M.E. ’77, State College, and director of the AIDS and had been special assistant to Professor of radiology at Jef- Pa., an anesthesiologist with HIV Research Center, was the dean of academic affairs ferson Medical College and Pocono Anesthesia Associ- elected to the Association of at the School of Medicine of director of the Jefferson Ultra- ates, P.C., was elected vice American Physicians last year. the University of Puerto Rico sound Research and Educa- president of the Pennsylvania and senior vice president of tion Institute, Goldberg is a Medical Society. He is slated Howard K. Rabinowitz, medical, dental, and profes- past president of the World to become president-elect M.D., G.M.E. ’76, professor of sional affairs for Blue Shield, Federation for Ultrasound in next October and president in family medicine at Jefferson Triple-S of Puerto Rico. Medicine and Biology. October, 2002. He is a former Medical College of Thomas

20 PENN MEDICINE Jefferson University, was vice dean for clinical affairs for activation of human airway Campbell Heart Institute. named to the Institute of the University of Pennsylvania smooth muscle. Medicine of the National Health System. An expert in Carmel M. Fratianni, M.D. Academy of Sciences. pulmonary diseases and criti- Pamela S. Douglas, M.D., ’88, Springfield, Ill., has joined cal-care medicine, he is a fel- G.M.E. ’84, is head of the car- the faculty at Southern Illinois Diane K. Jorkasky, M.D. ’77, low of the American College diovascular medicine section University School of Medicine who spent 13 years at of Physicians and of the Amer- at the University of Wiscon- as assistant professor of SmithKline Beecham, has ican College of Chest Physi- sin-Madison Medical School. endocrinology, metabolism, moved to Pfizer Pharmaceuti- cians. He is chair of COM- and molecular medicine. For cals as vice president for clin- PACCS, the national manpow- Gary A. Koretzky, M.D. ’84, five years, she was an instruc- ical sciences in Groton, Conn. er study on pulmonary and professor of pathology and tor in medicine at Harvard She had been a clinical pro- critical care. laboratory medicine at Penn, Medical School and an assis- fessor of medicine at Penn. is president of the American tant in medicine at Massachu- Society for Clinical Investiga- setts General Hospital. Richard D. Lackman, M.D. ’s tion. He is director of the sig- ’77, G.M.E. ’82, became chair 80 nal transduction program at of the Department of the Abramson Family Cancer ’s Orthopaedic Surgery at the John Q. Trojanowski, M.D., Research Institute. University of Pennsylvania Ph.D., G.M.E. ’80, professor 90 Health System last year. Pro- of pathology and laboratory Bruce T. Liang, M.D., G.M.E. Gary S. Tennyson, M.D., fessor of orthopaedic surgery, medicine at Penn, was elect- ’85, associate professor of Ph.D., G.M.E. ’90, has left he joined UPHS in 1999 as ed to the Association of medicine at Penn, was elect- Orange Park Medical Center chief of the orthopaedic American Physicians last ed to the American Society in Florida and joined the oncology service at Pennsyl- year. He is codirector of the for Clinical Investigation last Department of Pathology of vania Hospital. Center for Neurodegenera- year. He has developed cellu- the Mayo Clinic in Jack- tive Disease Research. lar, biochemical, and molecu- sonville, Fla. Lewis A. Lipsitz, M.D. ’77, lar principles for the study of has been appointed chief of Reed Tuckson, M.D., G.M.E. cardiac myocyte biology and Ronald G. Collman, M.D., the division of gerontology at ’81, who had been senior vice signal transduction. G.M.E. ’91, associate profes- Beth Israel Deaconess Med- president of professional stan- sor of medicine at Penn, was ical Center. Lipsitz, who has dards at the American Med- Julia M. Uffner, M.D. ’85, and elected to the American Soci- been a member of the Beth ical Association, was named Janice Kubo Hillman, M.D., ety for Clinical Investigation Israel Deaconess faculty for senior vice president of con- G.M.E. ’86, who practiced at last year. His research is more than 20 years, will con- sumer health and medical Bryn Mawr Medical Associ- focused on the viral and cel- tinue to serve as vice presi- care for UnitedHealth Group. ates, part of Penn’s Clinical lular basis of HIV-1 target-cell dent of medical affairs and He serves as the top physician Care Associates, have merged tropism, particularly the Usen Co-Director of the liaison for UnitedHealth, the their practice with Haverford macrophage tropism. Research and Training Insti- nation’s second-largest health Medical Associates. They are tute at Hebrew Rehabilitation insurer. now working with Michael D. Alexander C. Spyropoulos, Center for Aged in Boston. A Flanagan, M.D. ’83 M, and M.D. ’92, Albuquerque, N.M., professor of medicine at Har- Donald C. Dafoe, M.D., John Hobson, M.D. an internist practicing as a vard Medical School, Lipsitz G.M.E. ’82, was named the hospitalist, was elected a fel- is chair-elect of the Clinical Samuel D. Gross Professor Stuart R. Lessin, M.D., G.M.E. low of the American College Medicine Section of the and Chairman of Surgery at ’86, joined the medical oncolo- of Physicians – American Soci- Gerontological Society of Jefferson Medical College. gy department of Fox Chase ety of Internal Medicine, the America in 2001. His research Most recently, Dafoe was chief Cancer Center as director of society of internists. This dis- interests include falls, faint- of the transplantation pro- dermatology. He leads multi- tinction recognizes achieve- ing, blood pressure regula- gram at Stanford University specialty diagnostic and treat- ments in internal medicine, tion, cognitive dysfunction, Medical Center. He had earli- ment programs for melanoma the specialty of adult medical and improving long-term er served four years as chief of and other cancers of the skin. care. Medical director of the care for the disabled elderly. transplantation at Penn. Previously, Lessin was co- Clinical Thrombosis Center at director of the pigmented- Lovelace Health Systems, he is Mark A. Kelley, M.D., G.M.E. Michael D. Caldwell, M.D., lesion group at Penn and direc- also clinical assistant professor ’79, joined the Henry Ford G.M.E. ’83, has become direc- tor of the melanoma core facili- at the University of New Mex- Health System in Michigan tor of the Marshfield Medical ty at the University of Pennsyl- ico Health Sciences Center, last summer as executive vice Research and Education Foun- vania Cancer Center. One of where he is currently teaching president and chief medical dation in Marshfield, Wis. his special interests is cuta- a course in clinical thrombosis. officer. He was also named neous T-cell lymphoma, also After earning his M.D. degree chief medical officer of the Reynold A. Panettieri Jr., known as mycosis fungoides. from Penn, Spyropoulos com- Henry Ford Medical Group. M.D. ’83, G.M. ’90, associate pleted his residency at the For the previous year, Kelley professor of medicine at Penn, Robert Noel Piana, M.D. ’87, University of New Mexico had been a professor and a was elected to the American Nashville, has joined the divi- Health Sciences Center. vice chair of the Department Society for Clinical Investiga- sion of cardiovascular diseases of Medicine at Penn as well as tion last year. His research at Vanderbilt University Med- Elisa K. Ross, M.D. ’96, has chief of medicine at the focuses on the cellular and ical Center. He is director of joined Healthcare for Women Philadelphia VA Medical Cen- molecular mechanisms that cardiac catheterization labora- Only, a practice in Pottstown, ter. From 1990 to 1999, he was modulate cell growth and tories at the Vanderbilt Page- Pa.

2001/SPRING 21 AlumniNews

obstetrician-gynecologist; served with the Military 25 years at Temple, he was a April 13, 2000. He served as Medical Services in Japan for professor, associate dean, act- OBITUARIES president of the medical two years. ing dean, associate vice presi- board of the Western Penn- dent for affiliated hospitals, Hart Edgar Van Riper, M.D. sylvania Hospital from 1965 Harold N. Cole Jr., M.D. ’42, and executive director of ’30, Indianapolis, a retired to 1968 and then as the hospi- Daphne, Ala., a retired der- Temple’s North Philadelphia pediatrician who helped tal’s medical director from matologist; May 25, 2000. affiliates. He retired in 1987. A shepherd the development of 1973 to 1977. He received the During World War II, he former president of the polio vaccines; November 4, hospital’s Gold Headed Cane served in the Army Medical Philadelphia Blood Center, he 2000. Beginning as a pediatri- Award in 1969, given to Corps, primarily in the South also served as an examiner cian and medical director of someone with exemplary Pacific, and received the Pur- for the American Board of an insurance company in qualities as a physician, ple Heart. After completing Pediatrics. Madison, Wisc., he then teacher, and researcher. Dur- his residency at Bellevue joined the Children’s Bureau ing World War II he served as Hospital in New York City, Wade Rizk, M.D., G.M.E. ’46, of the Labor Department in captain of the West Penn he rose to associate clinical Jacksonville, Fla.; July 4, 2000. Washington, D.C. In 1945, he Hospital Unit, which was sta- professor at Case Western For 40 years, he served Jack- moved to the National Foun- tioned in England. He also Reserve University. He was sonville in various medical dation for Infantile Paralysis, traveled as staff physician for elected vice president of the positions. He was director of the forerunner of the March the Irving Berlin stage revue American Academy of Der- the Department of Radiology of Dimes Birth Defects Foun- “This is the Army,” which matology in 1971. After at St. Luke’s Hospital for a dation, where he served as toured to raise the morale of retirement, he served as an decade. A former president of medical director. He played a the troops. elder for the Spanish Fort the Northeast Florida Radio- central role as liaison in the Presbyterian Church. logical Society, he had also development of the Salk vac- Paul Strassburger, M.D. ’39, been president of the Duval cine and the Sabin vaccine, Little Silver, N.J., June 1, 2000. Paul G. Eglick, M.D. ’42, County Medical Society. In which were underwritten by He started his medical career Bethayres, Pa., a retired pedi- the 1960s, he was a pioneer of the Foundation and the Unit- at Columbia Presbyterian atrician; September 15, 2000. radiation oncology in Florida. ed States Public Health Serv- Hospital in New York City, He served his internship at ice. Van Riper then became then practiced at Mountain- Jewish Hospital, now the Lyle S. Powell, M.D. ’47, medical director and vice side Hospital in Glen Ridge Albert Einstein Medical Cen- Walnut Creek, Calif., an oph- president for medical affairs and St. Barnabas Medical ter, and his residency at The thalmologist; April 8, 2000. of Geigy Pharmaceuticals in Center in Livingston. He had Children’s Hospital of After serving in the Army Ardsley, N.Y. been the chief orthopaedic Philadelphia. During World during the Korean War, he surgeon at Overlook Hospital War II, he was a battalion sur- began his practice in Walnut Henry K. Erwin, M.D. ’33, in Summit, specializing in hip geon and a paratrooper with Creek. One of the founders of G.M. ’35, Allentown, Pa.; replacements, and was med- the 82nd Airborne Division. the John Muir Medical Cen- April 11, 2000. He interned at ical director at Orthospec, ter, he had also served as St. Luke’s Hospital, Fountain Inc., in Spring Valley, N.Y., Eugene E. Laigon Sr., M.D. chief of staff and board mem- Hill, Pa., and completed resi- for three years before retiring ’45, Coaldale, Pa.; July 14, ber. He built and raced cars dency programs in ophthal- in 1985. He served in the 2000. He was a physician in for 10 years, then became a mology at Penn from 1934-35 Navy during World War II. Coaldale for more than 50 pilot. A member of Chapter and Will’s Eye Hospital 1935- years, serving as chief of inter- 393 of the Experimental Air- 37. Appointed to St. Luke’s William H. Keffer, M.D. ’40, nal medicine at the former craft Association in Concord, Medical Staff in 1948, he rose Wyomissing, Pa., a retired Coaldale State General Hospi- he built and flew three air- to chief of the ophthalmology physician; September 23, tal. A former president of the craft of his own. section before retiring. 2000. At Reading Hospital, he hospital’s medical staff, he served as president of the had also been president of the Richard A. Dillard, M.D. ’48, I. Edward Rubin, M.D. ’35, directing staff in the 1960s medical societies of both Car- Birmingham, Ala., November G.M. ’46, Philadelphia, and later as senior physician. bon County and Schuylkill 8, 2000. He did his internship December 11, 2000. After During the Second World County. He was an Army vet- and surgical training at the completing his internship at War, he was a major in the eran of World War II. University of Alabama at Mount Sinai Hospital in Army Medical Corps in New Birmingham, then became Philadelphia and his residen- Guinea, the Philippines, and William Barba II, M.D. ’46, chief of surgery at the Veter- cy at Willard Parker Hospital Japan. He completed his resi- Jenkintown, Pa., former act- ans Hospital in Birmingham in New York, he opened a dency at the Mayo Clinic in ing dean and vice president for three years. In his private family medicine practice. He Rochester, Minn. A fellow of of Temple University School practice, he performed tho- later returned to Penn’s the American College of of Medicine; May 20, 2000. He racic, vascular, and general Graduate School of Medicine Physicians, he was elected to did his internship at Pennsyl- surgery. During the Korean to study ophthalmology. A the College of Physicians of vania Hospital, followed by War, he served a combat tour former clinical associate pro- Philadelphia. his pediatric residency at the with Destroyer Squadron 16. fessor of ophthalmology at University of Illinois Research A founder of the board of the Graduate School of Medi- Harry M. Klinger, M.D. ’41, and Educational Hospital. A directors of Brookwood Hos- cine, he also was associated Longboat Key, Fla., former former chief of pediatrics at pital. He was a founder and with Graduate Hospital. chief of staff of general sur- Roxborough Memorial Hospi- former president of the geons at Geisinger Medical tal, he served as director of Mountain Brook Swim and James N. Stanton Jr., M.D. Center in Danville, Pa; medical education at United Tennis Club. Inducted into ’37, Naples, Fla., a retired November 10, 2000. He Hospitals of Newark. In his the Alabama Tennis Hall of

22 PENN MEDICINE Fame in 1989, he served as Institute of Medicine of the Angel E. Enriquez, M.D., Back at MCP, he served as president of the Alabama National Academy of Sci- G.M. ’55, a professor of oto- chair of surgery from 1985 to Tennis Association. ences, he was president of the laryngology at the University 1989. He belonged to several American Association for of the Philippines and at the professional associations, Harvey O. Randel, M.D. ’48, Thoracic Surgery and chair- University of the City of including the American Insti- San Diego, October 25, 2000. man of the American College Manila; April 3, 2000. He tute for Ultrasound Medicine, A former U.S. Navy physi- of Surgeons. A former presi- cofounded the Philippine from which he received a cian, he was stationed with dent of the Society of Clinical Society of Otolaryngology Lifetime Achievement Award NATO forces in Naples, Italy Surgery, he also served as and later served as its presi- in 1999. He also received an before being assigned to the chairman of the New York dent. One of the authors of honorary doctorate from the Naval Hospital in San Diego State Transplant Council and the Philippine Textbook of Oto- University of Paris. in 1956. He did his fellowship as First Vice President of the laryngology, he was the first in allergy and clinical American Surgical Associa- editor of the Philippine Journal John S. O’Brien, M.D. ’59, a immunology at Scripps Clinic tion. He was coauthor of of Otolaryngology (1981-89). Punta Gorda, Fla., psychia- and Research Foundation. He Xenotransplantation: The Trans- He also served for several trist; May 3, 2000. After com- was promoted to commander plantation of Organs and Tis- years as president of the pleting his residency at the in 1959, began his civilian sues Between Species (1991) Philippine Board of Otolaryn- Institute of Living in Hart- medical career in 1962, and and was editor of two series gology. ford, Conn., he opened a pri- remained in the Naval of books. In 1999, he was the vate practice in St. Petersburg Reserve until 1974. Founding representative of the Class of Gerald L. Haidak, M.D., in 1965. Ten years later, he president of the San Diego 1949 at Penn Med’s gradua- G.M. ’55, Pittsfield, Mass.; established the Feedback Allergy Society, he also had tion ceremonies. April 30, 2000. He had been Center for pain diagnosis and served as president of the San in the departments of Surgery management. He later served Diego County Medical Soci- John W. Harrison, M.D. ’50, and Cell Biology at the Uni- as senior physician for the ety, the Lung Association of Ridgefield, Wash., a retired versity of Massachusetts Willough at Naples, Fla., a San Diego County, and the physician; November 7, 2000. Medical Center. center for alcohol and drug Western Society of Allergy He completed his training in addiction and eating disor- and Immunology. From 1974 internal medicine at the Eugene I. DiSalvo, M.D. ’57, ders, and as medical director to 1979, he was a trustee of Cleveland Clinic. During the G.M.E. ’62, Bethlehem, Pa.; of Al Amal Hospital in the California Medical Asso- Korean War, he served as April 29, 2000. He served his Damman, Saudi Arabia. A ciation. Twice elected presi- chief of medical service at the internship in general surgery former member of the Dis- dent of the Retired Officers 2500th Air Force Hospital on and his residency in trict Mental Health Board of Association, he also served Long Island, N.Y., and orthopaedic surgery at HUP. St. Petersburg, he was a on the boards of Meals on received a Commendation He was a captain and chief of founding board member of Wheels and was treasurer of Medal for Meritorious Serv- orthopaedic surgery in the the Developmental Center, a Project Life, which provided ice. An assistant clinical pro- Rodriguez United States non-profit agency for chil- housing and rehabilitation fessor at the University of Army Hospital from 1962 to dren with learning disabili- services. Washington Medical School, 1965. That same year he affili- ties. he was a former president of ated with Easton Hospital. Henry K. Reemtsma, M.D. the Northwest Rheumatism There, he served as chief of Felice J. Santore, M.D., G.M. ’49, emeritus professor of Society and a fellow of the orthopaedic surgery (1984- ’60, Rosemont, Pa.; January 5, surgery at Columbia Univer- American College of Physi- 2000); chair of the credentials 2001. A graduate of Temple sity School of Medicine and cians. His wife is Mary T. committee; president of the University School of Medi- pioneer in xenotransplanta- Harrison, M.D. ’50. medical staff (1994-98); and cine, he worked as an tion; June 23, 2000. After tak- chair of the executive com- internist for 13 years before ing his surgical residency at Barry J. Schwartz, M.D. ’54, mittee (1995-98). He also enrolling at Penn for training Presbyterian Hospital in New Villanova, Pa., psychiatrist; maintained a private practice as a surgeon and otolaryngol- York, he served as a U.S. April 25, 2000. He had been from 1965 until his death. He ogist. He had been president Marine Corps surgeon in the on the staff of the Institute of was a fellow of the American of the medical staffs at Korean War. In 1957, he Pennsylvania Hospital, where Academy of Orthopaedic Fitzgerald Mercy Hospital joined Tulane University as he completed his residency, Society and of the American and of Misericordia Hospital. an assistant professor of and he had an office at Intro- Back Society. He was a member of the surgery. At Tulane in 1963 spect Clinic in Lansdale. In senior medical staff at Lanke- and 1964, he performed his- 1975, he and Laurence H. Bernard Sigel, M.D., G.M.E. nau Hospital before retiring toric transplants of chim- Snow, M.D., G.M.E. ’62, ’58, Philadelphia surgeon; in 1985. panzee kidneys into humans. published a study on failure, December 26, 2000. He emi- After a brief stint at the Uni- in which they identified eight grated from Poland during Jeffrey W. Berger, M.D. ’92, versity of Utah’s School of failure-prone character types the Second World War. Ph.D., Cherry Hill, N.J., assis- Medicine, he joined the facul- and the qualities that cause Known for advancing the use tant professor of ophthalmol- ty of Columbia University in them to fail. A former dean of of ultrasound imaging, he ogy at the University of 1971, eventually serving as the Philadelphia Psychoana- spent most of his career at the Pennsylvania School of Medi- chair of the Department of lytic Academy, he had once Medical College of Pennsyl- cine; January 25, 2001, of can- Surgery, as the Valentine been president of the vania, where he had been cer. He also earned his Ph.D. Mott Professor of Surgery, Philadelphia Society for Ado- dean and acting president. In degree in biophysics from and as the Johnson & John- lescent Psychiatry. 1974, Sigel left MCP to become Penn. After a residency at the son Distinguished Professor dean of the University of Massachusetts Eye and Ear of Surgery. A member of the Illinois College of Medicine. Infirmary, he came to Penn’s

2001/SPRING 23 Following Andrew’s Example Scheie Eye Institute as a fel- Harry M. Burros, M.D., low in vitreoretinal diseases emeritus associate professor in 1996 and joined the faculty of urology in surgery and for- the following year. A retinal mer president of the medical specialist, he served as chief board of Graduate Hospital; of the retina service at the August 29, 2000. He came to Philadelphia VA Medical Penn in 1956 as an associate Center and was principal edi- professor of urology. In 1978, tor of a medical textbook, he became a clinical associate Age-Related Macular Degenera- professor of urology in tion (1999). He founded and surgery and held that post directed the Computer Vision until he became emeritus in Laboratory, which was fund- 1993. At Graduate Hospital, ed in part by a Career Devel- he was chairman of the urolo- erdinand G. Weisbrod, M.D. ’42, G.M. ’50, opment Award from Research gy department for more than remembers reading about the life of the industri- to Prevent Blindness, Inc., 30 years. He also was a staff alist/philanthropist Andrew Carnegie during his and in part by the National member of Underwood- undergraduate years at Penn. He never forgot Carnegie’s Eye Institute through his Memorial Hospital. F personal philosophy about wealth: Give money to your Mentored Clinician-Scientist Award. Berger was also prin- William W. Chambers, children but “don’t overdo it – too much money can cipal investigator of the Ph.D., emeritus professor of make them soft and non-productive.” Instead, Carnegie Reading Center for the NEI- anatomy; September 19, 2000. advised, leave most of your wealth to philanthropy. funded Complications of After earning his doctorate at “I decided then that if ever I achieved some sort of AMD Prevention Trial. As a Vanderbilt University, he wealth that I would present it to the University – the teacher, he had won the joined Penn in 1947. He place that was so important to me in finding my place in Department of Ophthalmolo- became a noted teacher and the world,” says Weisbrod. gy’s Golden Apple Award. researcher of the central ner- Throughout the next six decades, Weisbrod married, vous system and was instru- had three children, and embarked on careers in medi- mental in the reorganization cine and real estate. A combination of timing and talent of the course in neuroanato- my for first-year students. He led to his switch from medicine to real estate. In the early FACULTY DEATHS also helped found the Insti- 1970s, problems with the family real estate holdings led tute of Neurological Sciences Weisbrod to try his hand at the field. He figured he could Lester Baker, M.D., professor in 1953, one of the first such do a better job of managing the properties than the pro- of pediatrics at The Chil- groups in the United States fessionals. He was right. What began as a side job even- dren’s Hospital of Philadel- organized to stimulate multi- tually became an all-consuming second career; taking phia and director of Penn’s disciplinary study. advantage of a booming real estate market, he eventually Diabetes Research Center; acquired 35 properties. Then, in December, he created Howard Pollack September 17, 2000. He , M.D., emer- two charitable remainder trusts that will ultimately fund a received his M.D. degree itus professor of radiology professorship in the School of Medicine’s Division of from Columbia University and urology; September 20, and joined Penn as an assis- 2000. Internationally known Gastroenterology, his original field of interest. tant professor of pediatrics in for his pioneering work in “There are so many exciting things happening in 1966. Ten years later, he was using lithotripsy to crush kid- medicine today,” he says. “The pace of discovery is promoted to professor. He ney stones, he helped devel- accelerating all the time.” was a principal investigator op the use of imaging tech- Weisbrod’s generous gift also serves him well. In for a 10-year study, the Dia- niques such as ultrasound to addition to obtaining a generous current income tax betes Control and Complica- diagnose and treat diseases of deduction, he will receive a lifetime income stream tions Trial, and helped show the urinary and reproductive from the charitable remainder trusts. that rigorous control of systems. After earning his In his philanthropy, Weisbrod also hopes to impart blood-sugar levels can dra- medical degree from Temple the lesson he learned from Carnegie. “I think it’s impor- matically cut down serious University, he served as complications of diabetes. In chairman of radiology at tant to steer all Penn graduates toward a policy of giving 1994, he was honored as an Episcopal Hospital before gifts to the University, rather than to Uncle Sam – and outstanding clinician by the joining Penn in 1977. Author also to avoid giving too much to your children,” he says. American Diabetes Associa- of more than 200 scientific “Money can create more problems than it solves. But tion. Author of more than 100 papers, he wrote Clinical the gifts to the University are going to solve problems.” original articles, he cowrote Urography, considered the Weisbrod’s planned gift is just one of the creative gift the book Psychosomatic Fami- definitive textbook for the opportunities that would benefit both the School of Medi- lies: Anorexia Nervosa in Con- specialty. He served on edito- cine and its alumni. As you chart your financial futures, the text (1978). rial boards of more than a Planned Giving Office at the University of Pennsylvania dozen medical journals and Medical Center is ready to assist in developing the appro- Jeffrey W. Berger. See Class helped found the Society of of 1992. Uroradiology. priate strategy for you. Contact Marcie Merz, J.D., director of planned giving, University of Pennsylvania Medical Center, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309. E-mail: [email protected].

24 PENN MEDICINE Among Dr. Garret FitzGerald’s many roles are chairman of Penn’s Department of Pharma- cology, professor of cardiovas- cular medicine, director of the Center for Experimental Therapeutics, advocate of col- laborative science, champion of translational research, men- tor, runner of marathons, vora- cious reader, writer of elegant columns in his department’s newsletter – and chair of the American Heart Association’s Council on Arteriosclerosis, Thrombosis, and Vascular Biology. Although he says he’s spent more than 20 years working in one biochemical pathway, his research touches on such hot topics as COX-2 inhibitors, antioxidant vitamins, and the effects of alcohol.

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