Appendices
ACTs classified as quality assured
Formulation Active ingredients Manufacturer Manufacture site Brand name Package size and strength Artesunate + Tablets 50mg + Guilin Guilin, Guangxi, China Arsuamoon (1‐6yrs;7‐ 6;12;24 Amodiaquine 150mg Pharmaceutical Co. 13yrs; Adults) Ltd Artesunate + Tablets 50mg + Ipca Laboratories Dadra and Nagar Haveli AS‐AQ Generic (Child; 6;12;24 Amodiaquine 153mg / Limited (U.T.), India Junior; Adult) 153.1mg Artesunate + Tablets 50mg + Ipca Laboratories Dadra and Nagar Haveli Larimal (Child; Junior; 6;12;24 Amodiaquine 153mg / Limited (U.T.), India Adult) 153.1mg Artesunate + Tablets 25mg + Sanofi‐Aventis MAPHAR Laboratories, Coarsucam 25mg/67.5mg 3 Amodiaquine 67.5mg Group Casablanca, Morocco (Infant) Artesunate + Tablets 50mg + Sanofi‐Aventis MAPHAR Laboratories, Coarsucam 50mg/135mg 3 Amodiaquine 135mg Group Casablanca, Morocco (Toddler) Artesunate + Tablets 100mg Sanofi‐Aventis MAPHAR Laboratories, Coarsucam 3;6 Amodiaquine + 270mg Group Casablanca, Morocco 100mg/270mg (Child; Adult) Artesunate + Tablets 25mg + Sanofi‐Aventis MAPHAR Laboratories, Winthrop 25mg/67.5mg 3 Amodiaquine 67.5mg Group Casablanca, Morocco (Infant) Artesunate + Tablets 50mg + Sanofi‐Aventis MAPHAR Laboratories, Winthrop 50mg/135mg 3 Amodiaquine 135mg Group Casablanca, Morocco (Toddler) Artesunate + Tablets 100mg Sanofi‐Aventis MAPHAR Laboratories, Winthrop 100mg/270mg 3;6 Amodiaquine + 270mg Group Casablanca, Morocco (Child; Adult) Artesunate + Tablets 50mg + Strides Arcolab Bangalore, India ACTipal (Madagascar) 3, 6, 12 Amodiaquine 153mg Limited Artesunate + Tablets 50mg + Cipla Ltd Patalganga, India; Falcimon Kit & 6;12;24 Amodiaquine 153mg (200mg Goa, India Serenadose (DRC) salt) (Young children up to 6yrs; Children 7‐13yrs; Adults) Artemether + Tablets 20mg + Novartis Pharma Beijing, China; Coartem 20/120 6;12;18;24 Lumefantrine 120mg Suffern, USA Artemether + Tablets 20 gm+ Ajanta Pharma Ltd Paithan, Aurangabad, Artefan 20/120 6;12;18;24 Lumefantrine 120mg Maharashtra, India Artemether + Dispersible Novartis Pharma AG Novartis Pharmaceuticals Coartem‐D 6;12 Lumefantrine Tablets 20mg + Corporation, Suffern, USA 120mg Artemether + Tablets 20mg + Cipla Ltd Patalganga, India; Lumartem (5‐15kg; 15‐ 3;6;12;18;24 Lumefantrine 120mg Himachal Pradesh, India 25kg; 25‐35kg; >=35kg) Artemether + Tablets 20mg + Ipca Laboratories Dadra and Nagar Haveli Lumerax 20/120 6;12;24 Lumefantrine 120mg Ltd (U.T.), India Artemether + Tablets 20mg + Ipca Laboratories Dadra and Nagar Haveli AL Generic 6;12; 18;24 Lumefantrine 120mg Ltd (U.T.), India Artesunate + Tablets 50mg + Guilin Guilin, Guangxi, China Artecospe Co‐blistered Sulfadoxine / 500mg/25mg Pharmaceutical Co. 6+2 Pyrimethamine Ltd
Artesunate + Tablets 100mg Guilin Guilin, Guangxi, China Artecospe Co‐blistered Sulfadoxine / + 500mg/25mg Pharmaceutical Co. 6+3 Pyrimethamine Ltd
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Nationally registered ACTs
Benin’s nationally registered ACTs as of September 200823 Manufacture Active ingredients Formulation Strength Manufacturer Brand Name Site Artesunate / Amodiaquine Tablet 200mg / 200mg Dafra Belgium Amonate Artesunate / Amodiaquine Tablet 50mg / 153mg Ajanta India Apoxin Artesunate / Amodiaquine Tablet 50mg / 150mg Guilin pharma China Arsuamoon Artesunate / Amodiaquine Tablet 50mg / 153mg Sanofi Aventis Morocco Arsucam Artesunate / Amodiaquine Tablet 100mg / 153mg Odypharm England Artediam Artesunate / Amodiaquine Tablet 100mg / 300mg Pfizer USA Camoquin Plus Artesunate / Amodiaquine Tablet 200mg / 600mg Pfizer USA Camoquin Plus Artesunate / Amodiaquine Tablet 25mg / 67.5mg Sanofi Aventis Morocco Coarsucam Artesunate / Amodiaquine Tablet 50mg / 135mg Sanofi Aventis Morocco Coarsucam Artesunate / Amodiaquine Tablet 100mg / 270mg Sanofi Aventis Morocco Coarsucam Artesunate / Amodiaquine Tablet 50mg / 153mg Ipca India Larimal Artesunate / Amodiaquine Tablet 50mg / 200mg Macleods India Macsunate Plus Artesunate / Amodiaquine Tablet 25mg / 75mg Medinomics India Malmed Artemether / Lumefantrine Tablet 20mg / 120mg Ajanta India Artefan Artemether / Lumefantrine Tablet 40mg / 240mg Ajanta India Artefan Artemether / Lumefantrine Tablet 80mg / 480mg Ajanta India Artefan Artemether / Lumefantrine Tablet 20mg / 120mg Novartis Switzerland Coartem Artemether / Lumefantrine Powder 15mg / 90mg Dafra Belgium Co‐Artesiane Artemether / Lumefantrine Suspension 360mg / 2160mg / Dafra Belgium Co‐Artesiane 120ml Artemether / Lumefantrine Suspension 360mg / 2160mg / Dafra Belgium Co‐Artesiane 120ml Artemether / Lumefantrine Suppository 20mg / 120 mg Bliss Gvs India Lonart Artemether / Lumefantrine Tablet 20mg / 120mg Bliss Gvs India Lonart Artemether / Lumefantrine Suspension 180mg / 1080mg / Bliss Gvs India Lonart 60ml Artemether / Lumefantrine Tablet 40mg / 240mg Imex Health India Lufanter Artemether / Lumefantrine Tablet 20mg / 120mg Cipla India Lumartem Artemether / Lumefantrine Tablet 20mg / 120mg Macleods India Lumether Artesunate / Mefloquine Granules 50mg / 125mg Mepha Switzerland Artequin Paediatric Artesunate / Mefloquine Tablet 100mg / 125mg Mepha Switzerland Artequin Artesunate / Mefloquine Tablet 100mg / 250mg Mepha Switzerland Artequin Artesunate / Mefloquine Tablet 200mg / 250mg Mepha Switzerland Artequin Artemisinine / Naphthoquine Tablet 125mg / 50mg Kunming China Arco Artesunate / Tablet Stallion India Artecure Sulfamethoxypyrazine / ‐‐ Pyrimethamine Continued on following page
23 Nationally registered ACTs were compiled through the Ministry of Health in Benin.
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Manufacture Active ingredients Formulation Strength Manufacturer Brand Name Site Artesunate / Sulfadoxine / Tablet 100mg / 500mg / Plethico India Artedar Pyrimethamine 25mg Artesunate / Tablet 100mg / 250mg / Denk pharma Germany AsunateDenk 100 Plus Sulfamethoxypyrazine / 12.5mg Pyrimethamine Artesunate / Tablet 200mg / 500mg / Denk pharma Germany AsunateDenk 200 Plus Sulfamethoxypyrazine / 25mg Pyrimethamine Artesunate / Tablet 100mg / 250mg / Dafra Belgium Co‐Arinate Sulfamethoxypyrazine / 12.5mg Pyrimethamine Artesunate / Tablet 200mg / 500mg / Dafra Belgium Co‐Arinate Sulfamethoxypyrazine / 25mg Pyrimethamine Dihydroartemisinin / Granules 15mg / 120mg Steyuan pharm China Darte‐q Piperaquine Dihydroartemisinin / Capsule 40mg / 320mg Steyuan pharm China Darte‐q Piperaquine Dihydroartemisinin / Tablet 40mg / 320mg Holleypharm China Duo‐cotecxin Piperaquine Dihydroartemisinin / Tablet 40mg / 320mg Laboratoire Salvat India Malacur Piperaquine Dihydroartemisinin / Suspension 80mg / 640mg / 80ml Bliss Gvs India P‐Alaxin Piperaquine Dihydroartemisinin / Tablet 32mg / 320mg / 90mg Tonghe Pharma China Artecom Piperaquine / Trimethoprim Dihydroartemisinin / Tablet 60mg / 500mg / 25mg Bliss Gvs India Alaxin Plus Sulfadoxine / Pyrimethamine
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Final sample
List of clusters (Arrondissements) sampled, Benin, 2011. Refer to page 13 for an explanation of the booster sample approach for this survey.
Department Commune Arrondissement Censused cluster or booster sample?
Alibori Banikoara Toura Census Alibori Banikoara PHF booster sample Alibori Karimama Birni‐Lafia Census Alibori Karimama PHF booster sample Alibori Pharmacy booster sample Atacora Boukoumbe Tabota Census Atacora Boukoumbe PHF booster sample Atacora Pharmacy booster sample Atlantique Abomey‐Calavi Godomey Census Atlantique Abomey‐Calavi PHF booster sample Atlantique Toffo Ague Census Atlantique Toffo PHF booster sample Atlantique Pharmacy booster sample Borgou Bembereke Gomia Census Borgou Bembereke PHF booster sample Borgou Perere Sontou Census Borgou Perere PHF booster sample Borgou Pharmacy booster sample Collines Dassa‐Zoume Kpingni Census Collines Dassa‐Zoume PHF booster sample Collines Ouesse Kilibo Census Collines Ouesse PHF booster sample Collines Save Kaboua Census Collines Save PHF booster sample Collines Pharmacy booster sample Couffo Djakotome Djakotomey I Census Couffo Djakotome PHF booster sample Couffo Pharmacy booster sample Donga Bassila Penessoulou Census Donga Bassila PHF booster sample Donga Pharmacy booster sample Littoral Cotonou 1st Arrondissement Census Littoral Cotonou 9th Arrondissement Census Littoral Cotonou PHF and pharmacy booster sample Mono Grand‐Popo Sazoue Census Mono Grand‐Popo PHF booster samples Mono Pharmacy booster sample
Continued on following page
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Department Commune Arrondissement Censused cluster or booster sample?
Oueme Bonou Bonou Census Oueme Bonou PHF booster sample Oueme Porto‐Novo 2nd Arrondissement Census Oueme Porto‐Novo PHF booster sample Oueme Pharmacy booster sample Plateau Pobe Pobe Census Plateau Pobe PHF booster sample Plateau Pharmacy booster sample Zou Bohicon Lissezoun Census Zou Bohicon PHF booster sample Zou Pharmacy booster sample
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Survey team
List of staff members involved in the survey, Benin, 2011.
Team Leaders Interviewers Moudachirou BIAOU Laminou ASHANTI Abdoul Ramane CHABI Ben Youssouf BIO BANGANA Tayéwo CHACON Israel DOVONOU Roland AGBESSI Rachidatou CHABI GADO Gilles ACCROMBESSY Jean Claude GLELE Nellie AGUIDI Yves KOTAN Epiphane ABOGOURIN Marcellin ODOULAMI Ghyslaine BALOGOUN Additional quality control and supervision Noel Dona HOUETO Emmanual ACAKPO Rafatou KOKOKO Wilfred ADJANOHOUN Géraldo OGNIN Roger ATCHOUTA Rémi EKON K. Abdou Raman OLODO Gilles CODJIA Sai Sotima TCHANTIPO Hermine Lisette LOKOSSOU Prudencio NOUGLOKOU Armelle DAHOUNLINTON Augustine KPOTON Thierry ASSOGBA Oscar MEDO Baudoin ADINAKOU Hermione DAGNON Constant GANDJI Gynette GINDEHOU Maryse OGOULOLA Marc ADJERAN Serge Arnaud HOUNNOU Virginie GANGBADJO
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Description of outlet types visited for this survey 24
Public / Not for Profit Sector
Public Health Facilities N Description Government‐run health facilities that provide prescription Referral hospital 10 medicine following medical consultation or diagnosis. Fees (Hôpital de zone, or larger) are usually charged for consultations and medicines.
Arrondissement health centres are the first‐level of facility‐ Commune health centre 27 based public health care, and are usually staffed by nurses, a midwife, and auxiliary staff. They usually include a dispensary and maternity ward, although these facilities may also exist on their own. Arrondissement health centre 117 Commune health centres ‐ the next level ‐ are usually staffed by a doctor, nurses, and midwives. Across Benin’s 34 health zones, there is an average of 2 communes per Dispensary 17 zone.
Health‐zone level hospitals and the national referral hospital in Cotonou receive first‐level referral services and Maternity 11 typically are staffed with a surgeon and offer specialist health practitioners.
Village health units are staffed by voluntary community Village health unit 22 health workers and are linked to an arrondissement or communal health centre. Community health workers N Description This cadre of staff works at the community‐level, providing diagnosis and treatment where appropriate, and referring Community health workers (CHWs) 54 patients when required. CHWs are trained and supported by a variety of international NGOs, in partnership with the Ministry of Health. Private, not for profit facilities N Description
Non‐Governmental Organization 85 These facilities provide prescription medicine following (NGO) hospital / health centre medical consultation or diagnosis. They are usually staffed with qualified health practitioners, though some smaller Missionary hospital / clinic 8 clinics run by NGOs have less well qualified staff.
24 In total, 2,966 outlets were enumerated during data collection. The outlet classification was missing for 6 cases and they are therefore excluded from the breakdown presented here.
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Private‐for‐Profit Sector
Private facilities N Description
These are non‐governmental health facilities. Private clinics are smaller than hospitals and many of them are not Private hospital / clinic 171 registered with the Ministry of Health. They provide consultations and examinations, and sell prescription medicines at commercial prices.
Registered Pharmacies N Description
Registered pharmacies are licensed by the Ministry of Health and sell prescription medicine at commercial prices. The Pharmacy 205 outlets are staffed by qualified health practitioners, with oversight/supervision provided by a pharmacist. They sell all classes of drugs and are highly regulated.
General Retailers N Description
Businesses/points‐of‐sale which sell fast moving consumer Supermarket 12 goods (e.g. food, household products), in addition to some medicines (most often antipyretics). Drugs sold at these locations are not regulated. Boutiques are more formal Boutique 815 structures than stalls, ranging from lockable‐steel structures in markets, to outlets located in an arcade of shops, or occupying the ground floor of a house. Supermarkets are larger than boutiques, both in floor space and in the range of Boutique (in a market) 33 products they stock.
Stall (outside a market) 1,011 Stalls sell a variety of products that are displayed on tables (for example, on the roadside or in populated areas). They sell fast moving consumer goods and sometimes medicines. Stall (in a market) 221 Drugs sold at these locations are not regulated.
Itinerant drug vendors N Description
Itinerant salesmen who often sell products of unknown Hawkers 141 origin, including medicines.
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Pharmacy
NGO health centre (Centre medico social) Medicine selection carried by a hawker
Boutique (in a market) Stall (outside a market)
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Questionnaire
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Evidence for Malaria Medicines Policy