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Neuregulin Induces the Expression of Transcription Factors and Myosin Heavy Chains Typical of Muscle Spindles in Cultured Human Muscle
Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle Christian Jacobson*, David Duggan†, and Gerald Fischbach‡§ *Microarray Unit, Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; †Translational Genomics Research Institute (TGen), Phoenix, AZ 85004; and ‡Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032 Contributed by Gerald Fischbach, June 29, 2004 Neuregulin (NRG) (also known as ARIA, GGF, and other names) is (DRG) (28), proprioceptive sensory neurons in particular, ex- a heparin sulfate proteoglycan secreted into the neuromuscular press NRG early in development (14, 29, 30). While these junction by innervating motor and sensory neurons. An integral experiments were ongoing, reports appeared implicating NRG in part of synapse formation, we have analyzed NRG-induced the development of muscle spindles. Hippenmeyer et al. (14) changes in gene expression over 48 h in primary human myotubes. showed that NRG induces the expression of early growth We show that in addition to increasing the expression of acetyl- response 3 (Egr3), a transcription factor that is critical to the choline receptors on the myotube surface, NRG treatment results differentiation of muscle spindle fibers (31). Evidence for NRG’s in a transient increase of several members of the early growth role in spindle formation is re-enforced by the phenotypic response (Egr) family of transcription factors. Three Egrs, Egr1, -2, similarities between conditional Erb2 knockout animals and and -3, are induced within the first hour of NRG treatment, with Egr3 null mice (13, 15, 24). -
COLUMBIA Columbia University DIGITAL KNOWLEDGE VENTURES
COLUMBIA columbia university DIGITAL KNOWLEDGE VENTURES Brain and Mind May 13, 2004 Gerald D. Fischbach, MD Neuroscience and Neuropathology—Converging Streams Introduction by Lee Bollinger President Lee Bollinger: This symposium is the result of the very, very hard work of Professor Tom Jessell and Dr. Joanna Rubinstein, and I want to thank and acknowledge them, and would like to thank all of you for coming. This is a great testament to the general perceived importance of the subjects of this symposium. I want to thank all the speakers who have come to participate. I want to take this occasion just to announce that Columbia will be launching—we are launching, as of this moment—an institute for neuroscience that will be part (eventually) of the major center for the study of the brain and behavior. We all, I think, recognize in the academy the extraordinary advances that have come just in the past few decades, the past decade in particular, because of the discoveries around the genetic code. Where that will take us of course we don't know, and we're making very, very significant investments across the country in trying to advance knowledge as a result of that new knowledge. But the study of the brain and how it works is clearly central not only to the curing of disease, but also to the understandings that we bring to every, virtually every, area of life: social sciences, the professions, and the humanities. And it is Columbia's goal to try to bring as many scientific advances as we possibly can to this area, and also to integrate it with other areas of knowledge. -
Sir Hans Kornberg, FRS
Sir Hans Kornberg, FRS Hans Kornberg was born in Germany in 1928 to Jewish parents. Following the advent of Hitler, the life of the family became increasingly dangerous and in 1939 Hans was sent to live with an uncle in England. Hans was educated at Queen Elizabeth Grammar School, Wakefield and left at 17 to work as a laboratory assistant at the University of Sheffield under the supervision of Hans Krebs. The latter encouraged him to study further, which led to a degree in Chemistry and a PhD in Biochemistry at Sheffield where Hans carried out ground-breaking work on urea metabolism. Postdoctoral work encompassed a period in America on a Harkness Fellowship, followed by a very productive few years at the MRC Metabolism Research Unit at Oxford during which he and Krebs (by now Sir Hans Krebs and a Nobel Laureate) elucidated the glyoxylate cycle, an important process in bacterial metabolism. In 1960 Hans was appointed to a Chair at the University of Leicester with the remit to set up a new Department of Biochemistry. In July 1961 Hans and several colleagues set off from Oxford to visit the Department for the first time. Having lunched well en route, it was late afternoon by the time they arrived in Leicester. As it was during the long vacation the University was closed and they were forced to enter the Department, which in those days was located in the Fielding Johnson Building, via an open toilet window. Hans’ first year as Professor was largely taken up with appointing staff and converting the old chemistry teaching laboratories into accommodation suitable for biochemistry research and teaching. -
John Rodney Quayle 1 University of Bath Archives
John Rodney Quayle 1 University of Bath Archives Catalogue of the papers of John Rodney Quayle FRS (1926-2006) Title: Catalogue of the papers of John Rodney Quayle FRS (1926-2006) Compiled by: Clare Bannister & Lizzie Richmond Description level: Fonds Date of material: 1951-2015 Extent of material: 2 boxes, c 114 items Deposited in: University of Bath Library Reference code: GB 1128 John Rodney Quayle Collection 2019 Library, University of Bath. John Rodney Quayle 2 John Rodney Quayle 3 University of Bath Archives University of Bath Archives LIST OF CONTENTS Items Page GENERAL INTRODUCTION 4 SECTION A BIOGRAPHICAL A.1-A.10 6 SECTION B WRITINGS B.1-B.104 8 NOT ALL THE MATERIAL IN THIS COLLECTION MAY YET BE AVAILABLE FOR CONSULTATION. ENQUIRIES SHOULD BE ADDRESSED IN THE FIRST INSTANCE TO: THE ARCHIVIST THE LIBRARY UNIVERSITY OF BATH CLAVERTON DOWN BATH BA2 7AY John Rodney Quayle 4 John Rodney Quayle 5 University of Bath Archives University of Bath Archives GENERAL INTRODUCTION and was President of the Society for General Microbiology from 1990 to 1993. He was elected Fellow of the Royal Society in 1978. In the same year, for his outstanding contribution to biochemistry, he PROVENANCE received the Biochemical Society’s CIBA Medal. He was awarded honorary degrees by the universities of Göttingen, (1989), Sheffield (1992) and Bath (1992). The material was donated by Professor Quayle in 2003. DESCRIPTION OF THE COLLECTION BRIEF OUTLINE OF THE CAREER OF JOHN RODNEY QUAYLE The material is presented in the order given in the contents list. It covers the period from 1951 to John Rodney Quayle (known as Rod) was born in Hoylake, Merseyside, UK, in 1927. -
Review of the Year 2009/10
Invest in future scientific leaders and in innovation Review of the year 2009/10 1 Celebrating 350 years Review of the year 2009/10 02 Review of the year 2009/10 President’s foreword Executive Secretary’s report Review of the year 2009/10 03 Contents President’s foreword ..............................................................02 Inspire an interest in the joy, wonder Executive Secretary’s report ..................................................03 and excitement of scientific discovery ..................................16 Invest in future scientific leaders and in innovation ..............04 Seeing further: the Royal Society celebrates 350 years .......20 Influence policymaking with the best scientific advice ........08 Summarised financial statements .........................................22 Invigorate science and mathematics education ...................10 Income and expenditure statement ......................................23 Increase access to the best science internationally ..............12 Fundraising and support ........................................................24 List of donors ..........................................................................25 President’s Executive foreword Secretary’s report This year we have focused on the excellent This has been a remarkable year for the Society, our opportunity afforded by our 350th anniversary 350th, and we have mounted a major programme not only to promote the work of the Society to inspire minds, young and old alike, with the but to raise the profile of science -
Program and Abstracts
organized by Nael McCarty, T‐C Hwang, and Merritt Maduke SOCIETY OF GENERAL PHYSIOLOGISTS 67TH ANNUAL MEETING AND SYMPOSIUM MARINE BIOLOGICAL LABORATORY WOODS HOLE, MASSACHUSETTS PROGRAM AND ABSTRACTS The Society of General Physiologists would like to acknowledge the sponsors who have helped make this meeting such a prominent gathering of researchers. SGP Council 2012-2013 Councilors Baron Chanda, 10-13 President, Toshi Hoshi Crina Nimigean, 10-13 President-elect, Robert Dirksen Henry Colecraft, 11-14 Secretary, Andrew Harris Brad Rothberg, 11-14 Treasurer, Criss Hartzell Jorge Contreras, 12-15 Frank Horrigan, 12-15 Janice Robertson, 11-13 Daniel Basilio, 12-14 2013 Symposium Organizers Nael McCarty Emory University Tzyh-Chang Hwang University of Missouri Merritt Maduke Stanford Meeting Site Information Registration: Meeting registration takes place on the first floor of the Swope Center from 2:00 to 10:00 p.m. on Wednesday, September 5; and from 8:00 a.m. to noon on Thursday, September 6. Check-in is at the main desk in Swope Lobby (opposite the door) and your registration packets are at the first table on your left. If you arrive during the night, instructions are posted at Swope Center on how to contact the watchman who will have your room key. Mail/Messages: Private phones are available in nearly all guest rooms. Messages can be left at 508-548-3705 24 hours a day and are available for pickup at the front desk of Swope Center (phones in rooms do not have voice mail). Packages and mail should be addressed to your name, Society of General Physiologists, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543-1015. -
Neuregulin and Erbb Receptors Play a Critical Role in Neuronal Migration
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Neuron, Vol. 19, 39±50, July, 1997, Copyright 1997 by Cell Press Neuregulin and erbB Receptors Play a Critical Role in Neuronal Migration Carlos Rio,*³ Heather I Rieff,*²³ Peimin Qi,* the external germinal layer (EGL) and migrate inward and Gabriel Corfas*² along Bergmann radial fibers to their final destination, *Division of Neuroscience and Department the internal granule cell layer (IGL) (Rakic, 1971). In ro- of Neurology dents, this migration takes place during the first 2 post- Children's Hospital and Harvard Medical natal weeks. Granule cell migration has been studied School in vitro in both cerebellar slices and in cocultures of 300 Longwood Avenue dissociated cerebellar granule cells and astroglia. These ² Program in Neuroscience studies have implicated a number of molecules in steps Harvard Medical School of the migration process, for example, cell adhesion 220 Longwood Avenue molecules, i.e., AMOG (Antonicek et al., 1987; Gloor et Boston, Massachusetts 02115 al. 1990) and astrotactin (Zheng et al., 1996); ion chan- nels, i.e., NMDA receptors (Komuro and Rakic, 1993) and Ca21 channels (Komuro and Rakic, 1992). In addition, Summary studies of mutant mouse lines with defects in brain de- velopment have led to the identification of other mole- The migration of neuronal precursors along radial glial cules, including potassium channels in the case of the fibers is a critical step in the formation of the nervous weaver mutant (Rakic and Sidman, 1973; Patil et al., system. In this report, we show that neuregulin±erbB 1995); the extracellular matrix protein reelin in the reeler receptor signaling plays a crucial role in the migration mutant (Caviness and Sidman, 1973; D'Arcangelo et al., of cerebellar granule cells along radial glial fibers. -
World View by Georgina Ferry Remember What Science Owes to Child Refugees
A personal take on science and society World view By Georgina Ferry Remember what science owes to child refugees Callous policies in Brexit’s wake will ill serve able to study psychology at University College London, a nation that claims to cherish innovators — where she went on to hold one of the world’s first chairs learn from 1930s Britain, says Georgina Ferry. All would in psychopharmacology. In retirement, she continued her research, helping to establish an evidence base on the probably psychological effects of exercise. hen the British House of Commons voted have perished Kornberg, later knighted for his services to science, this month not to uphold child refugees’ but for a arrived in 1939 from northern Germany. Aged 11, he went right to join family members in the United to live with an uncle; both his parents died in the Holocaust. Kingdom, I was reminded of something. political On leaving school, he took a job as a technician with Hans As a scientific biographer and obituarist decision.” Krebs, a Jewish biochemist fired in 1933 by the University W(for Nature and the newspaper The Guardian), I’m regularly of Freiburg, Germany, because of his heritage. Krebs had struck by how much leading scientific nations have gained just discovered the cycle of energy transformation in cells, from people to whom they once gave sanctuary. for which he later won a Nobel prize. Kornberg went on to Every life — whether of an adult or a child — is valuable, reach heights of distinction he could not have dreamt of on and people should be saved for humanitarian reasons alone. -
And Neuropeptide Y-Immunoreactive Neurons in Rat and Monkey Neocortex’
0270.6474/84/0410-2497$02.00/O The Journal of Neuroscience Copyright 0 Society for Neuroscience Vol. 4, No. 10, pp. 2497-2517 Printed in U.S.A. October 1984 MORPHOLOGY, DISTRIBUTION, AND SYNAPTIC RELATIONS OF SOMATOSTATIN- AND NEUROPEPTIDE Y-IMMUNOREACTIVE NEURONS IN RAT AND MONKEY NEOCORTEX’ S. H. C. HENDRY,* E. G. JONES,*** AND P. C. EMSONS *James L. O’Leary Division of Experimental Neurology and Neurological Surgery and McDonnell Center for Studies of Higher Brain Function, Washington University School of Medicine, Saint Louis, Missouri 63110 and $ MRC Neurochemical Pharmacology Unit, Medical Research Council Centre, Hills Road, Cambridge CB2 2&H, England Received January 6,1984, Revised March 23,1934; Accepted March 30,1964 Abstract Neurons in the monkey and rat cerebral cortex immunoreactive for somatostatin tetradecapeptide (SRIF) and for neuropeptide Y (NPY) were examined in the light and electron microscope. Neurons immunoreactive for either peptide are found in all areas of monkey cortex examined as well as throughout the rat cerebral cortex and in the subcortical white matter of both species. In monkey and rat cortex, SRIF-positive neurons are morphologically very similar to NPY-positive neurons. Of the total population of SRIF-positive and NPY- positive neurons in sensory-motor and parietal cortex of monkeys, a minimum of 24% was immunoreactive for both peptides. Most cell bodies are small (8 to 10 pm in diameter) and are present through the depth of the cortex but are densest in layers II-III, in layer VI, and in the subjacent white matter. From the cell bodies several processes commonly emerge, branch two or three times, become beaded, and extend for long distances through the cortex. -
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C. Gunsalus 1912 Born in South Dakota, son of Irwin Clyde and Anna Shea Gunsalus 1935 B.S. in Bacteriology, Cornell University 1937 M.S. in Bacteriology, Cornell University 1940 Ph.D. in Bacteriology, Cornell University 1940-44 Assistant Professor of Bacteriology, Cornell University 1944-46 Associate Professor of Bacteriology, Cornell University 1946-47 Professor of Bacteriology, Cornell University 1947-50 Professor of Bacteriology, Indiana University 1949 John Simon Guggenheim Fellow 1950-55 Professor of Microbiology, University of Illinois 1955-82 Professor of Biochemistry, University of Illinois 1955-66 Head of Division of Biochemistry, University of Illinois 1959 John Simon Guggenheim Fellow 1959-60 Research sabbatical, Institut Edmund de Rothchild, Paris 1962 Patent granted for lipoic acid 1965- Member of National Academy of Sciences 1968 John Simon Guggenheim Fellow 1972-76 Member Levis Faculty Center Board of Directors 1977-78 Research sabbatical, Institut Edmund de Rothchild, Paris 1973-75 President of Levis Faculty Center Board of Directors 1978-81 Chairman of National Academy of Sciences, Section of Biochemistry 1982- Professor of Biochemistry, Emeritus, University of Illinois 1984 Honorary Doctorate, Indiana University 15/5/40 2 Box Contents List Box Contents Box Number Biographical and Personal Biographical Materials, 1967-1995 1 Personal Finances, 1961-65 1-2 Publications, Studies and Reports Journals and Reports, 1955-68 -
Alumni Director Cover Page.Pub
Harvard University Program in Neuroscience History of Enrollment in The Program in Neuroscience July 2018 Updated each July Nicholas Spitzer, M.D./Ph.D. B.A., Harvard College Entered 1966 * Defended May 14, 1969 Advisor: David Poer A Physiological and Histological Invesgaon of the Intercellular Transfer of Small Molecules _____________ Professor of Neurobiology University of California at San Diego Eric Frank, Ph.D. B.A., Reed College Entered 1967 * Defended January 17, 1972 Advisor: Edwin J. Furshpan The Control of Facilitaon at the Neuromuscular Juncon of the Lobster _______________ Professor Emeritus of Physiology Tus University School of Medicine Albert Hudspeth, M.D./Ph.D. B.A., Harvard College Entered 1967 * Defended April 30, 1973 Advisor: David Poer Intercellular Juncons in Epithelia _______________ Professor of Neuroscience The Rockefeller University David Van Essen, Ph.D. B.S., California Instute of Technology Entered 1967 * Defended October 22, 1971 Advisor: John Nicholls Effects of an Electronic Pump on Signaling by Leech Sensory Neurons ______________ Professor of Anatomy and Neurobiology Washington University David Van Essen, Eric Frank, and Albert Hudspeth At the 50th Anniversary celebraon for the creaon of the Harvard Department of Neurobiology October 7, 2016 Richard Mains, Ph.D. Sc.B., M.S., Brown University Entered 1968 * Defended April 24, 1973 Advisor: David Poer Tissue Culture of Dissociated Primary Rat Sympathec Neurons: Studies of Growth, Neurotransmier Metabolism, and Maturaon _______________ Professor of Neuroscience University of Conneccut Health Center Peter MacLeish, Ph.D. B.E.Sc., University of Western Ontario Entered 1969 * Defended December 29, 1976 Advisor: David Poer Synapse Formaon in Cultures of Dissociated Rat Sympathec Neurons Grown on Dissociated Rat Heart Cells _______________ Professor and Director of the Neuroscience Instute Morehouse School of Medicine Peter Sargent, Ph.D. -
January 25, 2000, NIH Record, Vol. LII, No. 2
R a Still The Second Best Thing About Payday NIH Promotes disABILITY HIGHLIGHTS Awareness Vannus Counsels Successor, Eyes By Sharon Ricks Future in Final Remarks to Press Perhaps they were captivated by the chorus Part Two of By Rich McManus of flying fingers or inspired by the keynote Varmus Interview (Second of two parts) address of pediatric neurologist Jan ust before his 73-month tenure as NIH director ended last Brunstrom. Whichever the case, employees Portrait of a Lasker month, Dr. Harold Varmus spoke at length about the future of attending NIH's Award Winner J TH, gave advice to his successor, and discussed gene therapy, annual Disability campus security and other matters. Even though he takes over as Awareness Day head of Memorial Sloan-Kettering Cancer Center in New York program recently Glenn, Shuttle City on Feb. 1, don't be surprised if you bump into him on left Natcher Astronauts To Visit campus; he advised NIH'ers in an all-hands email on his last Auditorium official day at work that he is still a special volunteer at NCI and knowing one remains in charge of the Varmus Lab in Bldg. 49 until that thing: laboratory migrates to MSKCC in April. " DisAbility More Depression So the Varmus Lab is moving with you? Counts." Screening Offered The whole intention of calling my lab the Varmus Lab was Dr. Jan Brunstrom The program that... (having set it up) I would take it down when I left. Several spotlighted key Intern Program of the folks in my lab are going to be moving, and there are some disability issues in the NIH community such Welcomes new people who are already coming to the new lab.