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HAPsHelp Version 2 Using HAPsHelp HapsHelp has been created to assist manufacturers in identifying sources of hazardous air pollutants (HAPs) in their manufacturing facilities, because many manufacturers use industrial products that may contain some amount of a HAP. While there are also a smaller number of companies that either manufacture HAPs or purchase HAPs for use in a manufacturing process, these companies should have no difficulty identifying and estimating their emissions. Here’s how to use HAPSHelp to identify sources of emissions for newly listed NR445 hazardous air pollutants, and other commonly reported HAPs: 1) Review the list of newly listed NR445 air toxics (see: Appendix) . Do you recognize any as chemicals that your company either manufactures, purchases as feedstock or produces as a process byproduct. If so, you must determine if you meet the definition of a regulated emitter under the rule, and if you do, calculate your emissions. 2) If possible, cross check your database of Material Safety Data Sheets (MSDS) against the list of NR445 chemicals using both the Chemical Abstract Service (CAS) number and the chemical name. If you find that your company purchases products containing regulated HAPs, search HAPsHelp for more information about the chemical. If you do not have a MSDS database, you can use HAPsHelp to identify the types of industrial products used by your company that might contain a listed HAPs. If you have any of those products in your facility, manually check the MSDS for that product to determine if it contains the listed HAP. 3) Review the HAPsHelp chemical profile for the listed HAP to determine the likely source of emission of the chemical, and identify opportunities for emission reduction, or product substitution so you can eliminate it from your facility entirely. How to Search in HAPsHelp HAPs Help utilizes the Adobe Acrobat Find option to help you locate the chemical profile you need. This search option is usually represented by the binocular icon, but can also be found in the Edit drop-down list. Either manually enter (or block and copy) the CAS number, or the chemical name or synonym into the search box, and your cursor will move to the appropriate profile. The name and CAS numbers of HAPs included in HAPSHelp are shown on the following list: i HAPs Help Chemicals CAS# NR445 Name 98-86-2 ACETOPHENONE 108-24-7 ACETIC ANHYDRIDE 124-04-9 ADIPIC ACID 106-92-3 ALLYL GLYCIDYL ETHER 97-56-3 AMINOAZOTOULENE; 0-(2-AMINOAZOTOULENE) 3825-26-1 AMMONIUM PERFLUOROOCTANOATE 7727-54-0 AMMONIUM PERSULFATE 1309-64-4 ANTIMONY TRIOXIDE 107-13-1 ACRYLONITRILE 207-08-9 BENZO[K]FLUORANTHENE 98-88-4 BENZOYL CHLORIDE 1304-82-1 BISMUTH TELLURIDE 75-27-4 BROMODICHLOROMETHANE 75-25-2 BROMOFORM 106-99-0 1,3-BUTADIENE 25013-16-5 BUTYLATED HYDROXYANISOLE 108171-26-2 CHLORINATED PARAFFINS 532-27-4 CHLOROACETOPHENONE 108-90-7 CHLOROBENZENE (MONOCHLOROBENZENE) 2698-41-1 CHLOROBENZYLIDENE MALONONITRILE 75-68-3 CHLORODIFLUOROETHANE 75-45-6 CHLORODIFLUOROMETHANE 106-89-8 1-CHLORO-2,3-EPOXYPROPANE (EPICHLOROHYDRIN) 569-61-9 C.I. BASIC RED 9 MONOHYDROCHLORIDE 7440-50-8 COPPER AND COMPOUNDS, FUME AS CU 108-93-0 CYCLOHEXANOL 108-94-1 CYCLOHEXANONE 108-91-8 CYCLOHEXYL AMINE 121-82-4 CYCLONITE 107-06-2 1,2-DICHLOROETHANE (ETHYLENE DICHLORIDE) (EDC) 109-89-7 DIETHYLAMINE 100-37-8 2-DIETHYLAMINOETHANOL 75-37-6 DIFLUOROETHANE 101-90-6 DIGLYCIDYL RESORCINOL ETHER 108-83-8 DIISOBUTYL KETONE 97-77-8 DISULFIRAM 106-88-7 EPOXYBUTANE 110-80-5 2-ETHOXYETHANOL; ETHYLENE GLYCOL MONOETHYL ETHER; CELLOSOLVE ii 111-15-9 2-ETHOXYETHYL ACETATE; ETHYLENE GLYCOL MONOETHYL ETHER ACETATE; EGEEA; CELLOSOLVE ACETATE 637-92-3 ETHYBUTYL ETHER (ETBE) 100-41-4 ETHYL BENZENE 7085-85-0 ETHYL CYANOACRYLATE 107-15-3 ETHYLENEDIAMINE 107-21-1 ETHYLENE GLYCOL VAPOR AND AEROSOL 22224-92-6 FENAMIPHOS 75-12-7 FORMAMIDE 64-18-6 FORMIC ACID 111-30-8 GLUTARALDEHYDE 7782-42-5 GRAPHITE (ALL FORMS EXCEPT GRAPHITE FIBER) 67-72-1 HEXACHLOROETHANE 822-06-0 HEXAMETHYLENE 1,6-DIISOCYANATE (HDI) 110-54-3 N-HEXANE 124-09-4 HEXANEDIAMINE 107-41-5 HEXYLENE GLYCOL 10035-10-6 HYDROGEN BROMIDE 1309-37-1 IRON OXIDE DUST AND FUME 78-79-5 ISOPRENE 1332-58-7 KAOLIN 301-04-2 LEAD ACETATE 109-86-4 2-METHOXYETHANOL; METHYL CELLOSOLVE; EGME 110-43-0 METHYL N-AMYL KETONE 110-49-6 METHYL CELLOSOLVE ACETATE; 2-METHOXYETHYL ACETATE 101-14-4 4,4'-METHYLENE BIS(2-CHLOROANILINE) 101-68-8 METHYLENE BISPHENYL ISOCYANATE 101-77-9 4,4'-METHYLENEDIANILINE (AND DIHYDROCHLORIDE) 110-12-3 METHYL ISOAMYL KETONE 108-11-2 METHYL ISOBUTYL CARBINOL 108-10-1 METHYL ISOBUTYL KETONE 21087-64-9 METRIBUZIN 110-91-8 MORPHOLINE 139-13-9 NITRILOTRIACETIC ACID 10024-97-2 NITROUS OXIDE 106-46-7 P-DICHLOROBENZENE (1,4-DICHLOROBENZENE 628-63-7 PENTYL ACETATE (MIXTURES AND ISOMERS) 62-44-2 PHENACETIN 108-95-2 PHENOL 88-89-1 PICRIC ACID 7727-21-1 POTASSIUM PERSULFATE 79-09-4 PROPIONIC ACID 107-98-2 PROPYLENE GLYCOL MONOMETHYL ETHER iii 110-86-1 PYRIDINE 82-68-8 QUINTOBENZENE 108-46-3 RESORCINOL 61790-53-2 SILICA-AMORPHOUS (DIATOMACEOUS EARTH), RESPIRABLE 69012-64-2 SILICA-AMORPHOUS: SILICA, FUME 60676-86-0 SILICA-AMORPHOUS: SILICA FUSED 14808-60-7 SILICA-CRYSTALLINE (RESPIRABLE SIZE) 26628-22-8 SODIUM AZIDE 7681-57-4 SODIUM METABISULFITE 7775-27-1 SODIUM PERSULFATE 7664-93-9 STRONG INORGANIC ACID MISTS CONTAINING >35% (BY WEIGHT) SULFURIC ACID 100-42-5 STYRENE MONOMER 14807-96-6 TALC (CONTAINING NO ASBESTOS FIBERS) 7440-25-7 TANTALUM, METAL AND OXIDE DUSTS, AS TA 811-97-2 1,1,1,2-TETRAFLUOROETHANE 116-14-3 TETRAFLUOROETHYLENE 109-99-9 TETRAHYDROFURAN 108-88-3 TOLUENE; TOLUOL 88-06-2 TRICHLOROPHENOL 102-71-6 TRIETHANOLAMINE 121-44-8 TRIETHYLAMINE 2451-62-9 TRIGLYCIDYL-S-TRIAZINETRIONE 118-96-7 TRINITROTOLUENE 126-72-7 TRISDIBROMOPROPYL PHOSPHATE 1314-62-1 VANADIUM PENTOXIDE, RESPIRABLE DUST OR FUME 108-05-4 VINYL ACETATE 100-40-3 VINYLCYCLOHEXENE 106-87-6 VINYL CYCLOHEXENE DIOXIDE; 4-VINYL-1-CYCLOHEXENE DIEPOXIDE 7440-65-5 YTTRIUM METAL AND COMPOUNDS, AS Y iv From Whence HAPsHelp HAPsHelp was developed by the University of Wisconsin Extension-Solid and Hazardous Waste Education Center, with funding provided by the USEPA Region V Pollution Prevention Grant Program, and the assistance of the Wisconsin Department of Natural Resources. The sources of information found in HAPsHELP include: NR 445 American Conference of Governmental Industrial Hygienists Chemical Abstract Service Environmental Protection Agency National Institute for Occupational Safety and health, National Toxicology Program 9th Report on Carcinogens New Jersey Department of Health and Senior Services Occupational Safety and Health Administration Solid and Hazardous Waste Education Center What is NOT Included in HAPsHelp HAPSHelp includes a subset of the complete list of NR445 chemicals. The full list of new NR445 Hazardous Air Pollutants can be found in the Appendix, with those chemicals listed in HAPSHelp marked. Those HAPs that would not normally be expected to be found in a manufacturing facility, or are not commonly reported to the DNR Air Emissions Inventory, can be found in the text of the NR445 rule, see: https://dnr.wi.gov/topic/airquality/toxics.html DSL - August 2004 v HAPs Help Chemical Profile CAS# 10024-97-2 Name NITROUS OXIDE (N2O) Chemical Structure - Synonyms Dinitrogen monoxide; hyponitrous acid anhydride; Nitrogen Oxide; O Dinitrogen oxide; N+ N Occupational Exposure Limits: TLV: 50 ppm; 90 mg/m3 as TWA (ACGIH 1991-1992). NIOSH REL: TWA 25 ppm (46 mg/m3) Toxicity May have effects on the bone marrow. May cause reproductive toxicity in humans. Examples of Products Used by Industry Containing Nitrous Oxide NONE Potential for Emission As a gas WI Air Toxics Emission Threshold (NR445) 4.84 lb/hour WI Emission Inventory Reporting Threshold (NR438) 6,000 lb//year Opportunities for Source Reduction Leak control Discussion Manufacturers using nitrous oxide gas should evaluate the potential for emission. 1 HAPs Help Chemical Profile CAS# 10035-10-6 Name Hydrobromic Acid (BrH) Chemical Structure Synonyms Hydrobromide acid; HYDROGEN BROMIDE; Hydrogen bromide H Br in acetic acid; Occupational Exposure Limits TLV: 3 ppm; (ceiling value) (ACGIH 2000). OSHA PEL: TWA 3 ppm (10 mg/m3) NIOSH REL: C 3 ppm (10 mg/m3) NIOSH IDLH: 30 ppm Toxicity Not Available Examples of Products Used by Industry Containing Hydrogen Bromide PHOTOGRAPHIC BLEACH PHOTOGRAPHIC DEVELOPER SOLDERING FLUX Potential for Emission As Gas WI Air Toxics Emission Threshold (NR445) 0.741 lb/hour WI Emission Inventory Reporting Threshold (NR438) 3,247 lb/year Opportunities for Source Reduction Emission Control Discussion Chemical manufacturers that use hydrogen bromide should as a feedstock should evaluate leak potential. 2 HAPs Help Chemical Profile CAS# 100-37-8 Name Diethylaminoethanol (C6H15NO) Chemical Structure Synonyms 2-DIETHYLAMINOETHANOL; 2-hydroxytriethylamine; 2-N,N-diethylaminoethanol; beta-diethylaminoethanol; beta-hydroxytriethylamine; diethyl(2-hydroxyethyl)amine; N Diethylaminoethanol; Diethylethanolamine; DEAE; n-diethylaminoethanol; HO N,N-Diethyl-2-hydroxyethylamine; N,N-Diethylaminoethanol; N,N-Diethylethanolamine; N,N-diethyl-N-(beta-hydroxyethyl)amine Occupational Exposure Limits TLV: as TWA 2 ppm (skin) (ACGIH 2001). MAK: 5 ppm; 24 mg/m3; H (2001). OSHA PEL: TWA 10 ppm (50 mg/m3) skin NIOSH REL: TWA 10 ppm (50 mg/m3) skin NIOSH IDLH: 100 ppm Toxicity Not available Examples of Products Used by Industry Containing 2-DIETHYLAMINOETHANOL ADHESIVE PRIMER ELECTRICAL INSULATING COMPOUND BOILER COMPOUND FLOOR WAX CLEANING COMPOUNDS HYDRAULIC FLUID COOLING WATER ADDITIVE PHOTOGRAPHIC DEVELOPER Potential for Emission As vapor or mist WI Air Toxics Emission Threshold (NR445) .52 lb/hour WI Emission Inventory Reporting Threshold (NR438) 2,255 lb/year Opportunities for Source Reduction Manufacturers that formulate products using 2-DIETHYLAMINOETHANOL should calculate emission rates.
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    This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles.
  • Purification and Characterization of a Novel Nitrilase of Rhodococcus

    Purification and Characterization of a Novel Nitrilase of Rhodococcus

    JOURNAL OF BACTERIOLOGY, Sept. 1990, p. 4807-4815 Vol. 172, No. 9 0021-9193/90/094807-09$02.00/0 Copyright X3 1990, American Society for Microbiology Purification and Characterization of a Novel Nitrilase of Rhodococcus rhodochrous K22 That Acts on Aliphatic Nitriles MICHIHIKO KOBAYASHI,* NORIYUKI YANAKA, TORU NAGASAWA, AND HIDEAKI YAMADA Department ofAgricultural Chemistry, Faculty ofAgriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan Received 18 April 1990/Accepted 8 June 1990 A novel nitrilase that preferentially catalyzes the hydrolysis of aliphatic nitriles to the corresponding carboxylic acids and ammonia was found in the cells of a facultative crotononitrile-utilizing actinomycete isolated from soil. The strain was taxonomically studied and identified as Rhodococcus rhodochrous. The nitrilase was purified, with 9.08% overall recovery, through five steps from a cell extract of the stain. After the last step, the purified enzyme appeared to be homogeneous, as judged by polyacrylamide gel electrophoresis, analytical centrifugation, and double immunodiffusion in agarose. The relative molecular weight values for the native enzyme, estimated from the ultracentrifugal equilibrium and by high-performance liquid chromatog- raphy, were approximately 604,000 + 30,000 and 650,000, respectively, and the enzyme consisted of 15 to 16 subunits identical in molecular weight (41,000). The enzyme acted on aliphatic olefinic nitriles such as crotononitrile and acrylonitrile as the most suitable substrates. The apparent Km values for crotononitrile and acrylonitrile were 18.9 and 1.14 mM, respectively. The nitrilase also catalyzed the direct hydrolysis of saturated aliphatic nitriles, such as valeronitrile, 4-chlorobutyronitrile, and glutaronitrile, to the correspond- ing acids without the formation of amide intermediates.
  • Chemical Name Federal P Code CAS Registry Number Acutely

    Chemical Name Federal P Code CAS Registry Number Acutely

    Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime.
  • Most Common Substances in Chemicals for Different Industries

    Most Common Substances in Chemicals for Different Industries

    Table 14 Most common substances by industry Figures for 2009. Substances contained in more than 10 products. A substance can be omitted for secrecy reasons. Industry CAS-no Substance Number of products A01 Agriculture 7732-18-5 Water 458 6484-52-2 Nitric acid ammonium salt 77 57-55-6 1,2-Propanediol 75 64742-65-0 Distillates (petroleum), solvent-dewaxed heavy 74 paraffinic 63148-62-9 Siloxanes and Silicones, di-Me 60 57-13-6 Urea 54 67-63-0 2-Propanol 54 11138-66-2 Xanthan gum 53 7783-20-2 Sulfuric acid diammonium salt 53 7722-76-1 Phosphoric acid, monoammonium salt 52 7487-88-9 Sulfuric acid magnesium salt (1:1) 51 7447-40-7 Potassium chloride 46 56-81-5 1,2,3-Propanetriol 44 7778-80-5 Sulfuric acid dipotassium salt 43 1310-73-2 Sodium hydroxide 41 7647-14-5 Sodium chloride 41 2634-33-5 1,2-Benzisothiazol-3(2H)-one 38 1310-58-3 Potassium hydroxide 33 7757-79-1 Nitric acid potassium salt 33 7785-87-7 Manganese sulfate 32 7664-38-2 Phosphoric acid 32 72623-87-1 Lubricating oils, petroleum, C20-50, 31 hydrotreated neutral oil-based 64741-89-5 Distillates (petroleum), solvent-refined light 29 paraffinic 77-92-9 1,2,3-Propanetricarboxylic acid, 2-hydroxy- 28 8061-51-6 Lignosulfonic acid, sodium salt 28 7778-18-9 Sulfuric acid, calcium salt (1:1) 27 64-17-5 Ethanol 27 14807-96-6 Talc 26 64742-94-5 Solvent naphtha (petroleum), heavy arom. 25 68649-42-3 Phosphorodithioic acid, O,O-di-C1-14-alkyl 24 esters, zinc salts (2:1) 64-02-8 Glycine, N,N'-1,2-ethanediylbis[N- 24 (carboxymethyl)-, tetrasodium salt 64-19-7 Acetic acid 23 99-76-3 Benzoic acid,
  • TSCA New Chemicals Notices Received File:///W:/Oneepa/Newchems/Pubs/5D2-IMD/PMN-SNUN-MCAN-T

    TSCA New Chemicals Notices Received File:///W:/Oneepa/Newchems/Pubs/5D2-IMD/PMN-SNUN-MCAN-T

    TSCA New Chemicals Notices Received file:///W:/OneEPA/Newchems/pubs/5d2-IMD/PMN-SNUN-MCAN-T... TSCA New Chemicals Notices Received April, 2020 Received Case No. Version Manufacturer Use Chemical Substance Date (S) A lubricating agent used in the SN-19-0004A 4 06/04/2019 CBI production of (G) Pitch coke automotive disc brakes Molecular SN-19-0005A 2 05/28/2019 (G) Conductive ink (S) Functionalized multiwall carbon nanotubes Rebar Design (G) Carboxylic acids, unsaturated, polymers with disubstituted (G) Polymer for amine, alkanediol, substituted alkylpropanoic acid, alkanedioic P-16-0442A 4 06/26/2019 CBI coatings acid and substituted isocyanatocycloalkane, compds with alkylamine (G) Carboxylic acids, unsaturated, hydrogenated polymers with (G) Polymer for disubstituted amine, alkanediol, substituted alkylpropanoic P-16-0443A 4 06/26/2019 CBI coatings acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine (G) Polymer for P-16-0444A 4 06/26/2019 CBI (G) Amine salted polyurethane coatings (G) Carboxylic acids, unsaturated, hydrogenated polymers with (G) Polymer for substituted alkanediamine, alkanediol, substituted P-16-0445A 4 06/26/2019 CBI coatings alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine P-17-0007A 5 06/13/2019 CBI (S) Intermediate (G) Dialkyl 7,10-dioxa, dithiahexadeca diene (G) Substituted carboxylic acid, polymer with 2,4-diisocyanato- (G) Adhesive for 1-methylbenzene, hexanedioic acid, alpha-hydro-omega- P-17-0239A 6 06/11/2019 CBI open non-descriptive