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March 5, 1991, NIH Record, Vol. XLIII, No. 5

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March 5, 1991, NIH Record, Vol. XLIII, No. 5 March ), 1991 Vol. XLIII No. "Still U.S. Department of Health The Serond and Human Services Best Thing About Payday" National Institutes of Health e Recori A Year in the Life... New Drug Shown To Benefit Hereditary Immune Disorder Project Turns High Schoolers Into NIH Researchers By Laurie K . Doepel By Carla Garnet< A new drug chat enhances the immune Afore than half their year-long NIH stay is with fresh eyes and eager ears, and just as response has had dramatic success in treating over, but the time has been well spent. importantly, additional hands. the hereditary immune disorder chronic gran­ They know the language now and they cas­ To the students, it meant leaving school 4 ulomatous disease (CGD), scientists reported ually toss around phrases like "subdoning a days a week after lunch en route ro the Jab, in a recent issue of New England Jonrnal of gene" and "subject to mutagenesis," phrases forfeiting most extracurricular activities and Medicine. The drug, recombinant gamma peculiar to medical research milieus. free time with friends, and volunteering for interferon, reduced the frequency of serious They know the basic techniques and they extra science assignments and homework. To infections by about 70 percent in patients confidently pipette murky liquids into or out their futures, their decision meant the chance with CGD. A genetic defect leaves people of designated containers. They look like they of a lifetime. with CGD vulnerable to certain life­ know what they are doing. They are familiar "Working at NIH is a far different threatening infections. The drug was twice as fixtures in their various research experience than anything I would normally effective as antibiotics, the current mainstay of environments-and the oldest among them find in high school or even in college," said CGD treatment. just celebrated his l7 ch birthday about 2 Stacy Marcus, a 16-year-old Kennedy High "These findings are important not only weeks ago. School student working in NICHD's Labora­ because they will help children with CGD, Encouraged co don N IH labcoats and tory of Molecular Genetics. but also because we now have a precedent for explore dajJy hands-on research, nine .. It's a rare experience to be in high school Montgomery County high school juniors came and working in a lab," agreed Gaithersburg co campus last June and decided ro stay. junior Tony Scott, 16, who is thinking of Their decision meant a loc of things ro a lot majoring in pre-med studies in college. He of people: To NIH's then newly created Office works in the Laboratory of Biological Chemis­ of Education, it meant a chance to co-launch, try at NCI. 'Tm learning things I wouldn't with the Howard Hughes Medical Institute, ordinarily learn and learning chem on a much the office's first pilot projecc co attract young higher level," he said. would-be scientists. To institute researchers, it (See STUDENTS, Page 6 ) meant an opportunity co share their science New Paging Device Available Mainly Affects Women To the Hearing Impaired Conference Weighs Surgery Risks in HPT Patients By Anne Barber By Jane DeMouy A rthur Lee Jones recently received a gift--a paging device. Jones will wear the device at F or some patients with asymptomatic pri­ all times while at work. This special pager mary hyperparachyroidism (HPn, con­ assists hearing-impaired employees in the scientious monicoring is an appropriate airer­ event of an emergency by vibrating and then native co surgery, according to a recent NIH displaying a message telling the wearer which consensus panel convened by NIDDK and the building is being evacuated. Office of Medical Applications of Research. The pager is part of a system char has been Primary hyperparathyroidism is usually installed in Bldgs. 7, 8, 13, 30, 3 1, 36, 38 caused by a benign tumor of one of the four and 4 1 where there are identified hearing­ parathyroid glands, which releases parathyroid impaired employees. "We are now working on CGD patient .JameJ Mann, at age 4, plays with hormone (PTH), which in turn aces co raise Bldgs. 4, 9, 29, 29A and 38A," says Richard his moiher at the Clinical Center playground. blood calcium. Hyperparachyroidism can cause E. Shaff, chief, Emergency Management bone loss with potential fractures, kidney Branch. testing gamma interferon in other patients problems, neuromuscular weakness, and ocher If ~•ou know of any hearing-impaired with compromised immune defenses who are common sympcoms. Removal of the affected employees located in buildings nor identified susceptible to recurrent infections such as gland by an experienced surgeon is a highly here, please notify Shaffs office, 496-1985. If patients on cancer chemotherapy, neonates, successful treatment for primary you are hearing impaired and need a paging the aged, and victims of trauma," said Dr. hypcrparathyroidism. device, contact your administrative office. John l. Gallin, director of NIAID's Division Mulriphasic screening tests are now identi­ According co Libby McKnight, a sign lan­ of Intramural Research and one of the seven fying approximately 100,000 new cases of guage interpreter in the Division of Equal principal investigators on the study. HPT in the United Stares annually, but Opportunity, NIH has approximately 40-45 The International Chronic Granulomatous because many of these patients have no symp­ deaf employees. Disease Cooperative Study Group, composed toms other than elevated levels of calcium, Jones works as an animal caretaker for of researchers at 13 medical centers world­ their treatment has been controversial. The N INOS in Bldg. 36, and had to depend on wide, conducted the study under the risk of hyperparathyroidism increases with age, coworkers to locate him in case of evacuation. sponsorship of Genentech, Jnc. , of South San (See HPT, Page 2 J <See PAGER, Page 7) (See CGD, Page 4 ) page 2 The Record March ~. l991 HPT considered cost effective. They may be useful, (Continued from Page 1.J however, if a previous operation failed. Finally, the panel called for a randomized, and occurs most often in postmenopausal multiccnter clinical trial to compare surgical women. and medical management of HPT and for [n discussing the "Diagnosis and Manage­ basic research on the pathogenesis of the con­ ment of Asymptomatic Primary dition and the development of pharmacologic Hyperparathyroidism," che panel said diag­ treatmencs for the disease. D nosis of H PT is based on two findings­ pcrsiscenc hypercalcemia and elevated scrum parathyroid hormone. New immunoassays for DCRT Holds Seminar on Mac PTH have helped improve diagnosis. Software for Scientists Some paciencs may present without signs or Software for the Macint-osh has developed symptoms of the disorder. These patients need rapidly in the last few years, with a wide not have surgery, the panel said, if a baseline range of application programs now available evaluation finds no evidence of complications for scientists. Areas of potential interest co and they are conscientiously monitored for NIH researchers include extremely user­ progression of the disease. friendly systems for statistical analysis, The panel said that a patient qualifying for publication-quality graphics and charting, nonsurgical management must have serum cal­ powerful numerical computation and extensive cium that is only mildly elevated, no previous special function libraries, full "what you see is episodes of life-threatening hypercalcemia, and what )'OU get" palette-driven equation and for­ normal kidney and bone status. Surgery would mula setting for rapid PostScript scientific text be indicated for an asymptomatic patient with preparation, and gene sequencing information Geraldine Dietz Fox, chair of the N IDCD any of the following: markedly elevated serum and data management. Advisory BoaYd, was named a winner of the DiJ­ calcium; a history of an episode of life­ On Apr. 3 and 4, the DCRT Computer tinguished Service Award from the American threatening hypercalcemia; reduced creacinine Center Training Unit will cover these areas in Speech-Language-Hearing Association (ASHA ). clearance; presence of kidney scone(s) detected six 90-minute modules that will present The award was presented by Roy A. Koenigsknecht, by abdominal radiograph; a markedly elevated expert introductions co: past president of ASHA, "for her tit"eless work O!I 24-hour urinary calcium excretion; or substan­ • )MP, from SAS Institute: statistics, behalf of the 24 million Americans with speech, tially reduced bone mass. The panel also exploratory data analysis and graphics. language and hearing disorders who will be11efit advised surgery where followup is unlikely, a • SYSTAT, from Intelligent Software: full from the research supported by the institute." coexistent illness complicates management, or featured statistics and plotting system. the patient is less than 50 years old, since the • KalcidaGraph, from Synergy Software: effects of decades of asymptomatic HPT are curve fitting and statistical graphics. unknown, and younger patients will have a • Mathematica, from Wolfram Research: longer life expectancy over which monitoring The NilI Record intensive numerical computations, 2 and 3-D Publ;shed biweekly at Bethesda, Md., by the Editorial must occur. plotting, symbolic manipulation, advanced The choice between surgery and medical Opera,ions Branch, Division of Public Information, for the equation solving, extensive function library. information of employees of rhe Narion.al lnstirutes of management should be '"founded on clinical • MathType, from Design Science: palette­ Health, Dcpamnent of Health and Human Services, and judgment on a case-by-case basis," according driven equation and formula typesetting. circulated to nonemployees by subscription only through co panel chair Dr. J ohn Poets, physician-in­ • Mac Vector, from !BI, Inc.; DNA Strider; rhe Government Prinrjng Office. The content is reprincable chief at Massachusetts General Hospital. How Gene Construction Kit, from TextCo: DNA without permission. Pictures may be available on request. co balance the need to identify skeletal, renal, sequencing and library processing.
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