A BIG SMALL WORLD

Symposium 2021

FEBRUARY 9, 2021 | 8.45 A.M.

Joint online symposium between the study associations T.S.V. 'Jan Pieter Minckelers' and SvBMT Protagoras of respectively the faculties of chemical engineering and and biomedical engineering! SPONSORS

PREFACE

Dear participant, On behalf of the Japie-Protagoras Symposium Committee I would like to welcome you to the symposium ‘A BIG Small World’. , the manipulation of matter on an atomic, molecular and supramolecular scale, has been a large topic of interest in research lately. In healthcare, nanotechnology holds immense potential, from improved disease diagnosis to drug delivery by customizing molecular systems. During the symposium the subject of nanotechnology in healthcare will be viewed from different angles. Examples of questions that will be answered are: Can diseases like cancer be treated better using the latest advancements in nanotechnology? Can synthetic complexes serve as artificial cells? Can the extracellular matrix be mimicked by synthetic supramolecular materials? How can the production of active pharmaceutical ingredients be improved by developing new chemistries and optimizing flow technology? How can liquid crystals be used to create optical sensors for medical applications? How can nanotechnology be used to improve functional polymer coatings for bio interface applications? Although this symposium will be held online, we would like to involve the participants as much as possible. There will be a possibility to ask questions after each lecture and during the lunch break and after the lectures there will be plenty of room to get to know the companies and discuss the research of our speakers during the (virtual) drink. With this symposium we hope to motivate young to change the world at the smallest scale! We wish you an inspiring and pleasant day! On behalf of the Japie-Protagoras Symposium Committee 2021, Lisa Cattenstart Chairman

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. CONTENT

Program 5 Chaiman of the day 6 Prof. Dr. Ir. 8 ICMS: Prof. Dr. Ir. Jan van Hest 10 Aspen Oss BV: Dr. DJ van Zoelen 12 Ir. Marle Vleugels 14 Ir. Annelies Wauters 16 Ir. Y. Foelen 18 Prof. Dr. Patricia Dankers 20 Prof. Dr. Rainer Haag 22 Prof. Dr. Tanja Weil 24 Prof. Dr. Willem Mulder 26 VSI/e 28 Committee of recomendation 29 Committee 30 Organisation 31 Aknowledgements 32

PROGRAM

08.15-08.45 Welcoming of guests 08.45-09.15 Opening of the symposium by Committee chairman Lisa Cattenstart and chairman of the day Prof. Dr. 09.15-09.55 Prof. Dr. Ir. Jan van Hest: 'Adaptive polymer assemblies for biomedical applications' 10.00-10.40 ICMS, Prof. Dr. Ir. Jan van Hest: 'How to apply an interdisciplinary approach with powerful toolboxes of advanced analysis techniques to fascinating scientific challenges for the next generation of “smart” and advanced materials.' 10.45-11.00 Coffee break 11.00-11.40 Aspen Oss BV, Dr. DJ van Zoelen: 'Sustainability in API production: from a more or less buzzword in the past to a fully integrated new lifestyle today' 11.45-12.25 PhD presentations 12.35-12.45 Closure of the morning section 12.45-13.30 Lunch 13.30-14.10 Prof. Dr. Patricia Dankers: 'Synthetic extracellular matrices based on supramolecular materials' 14.15-14.55 Prof. Dr. Rainer Haag: 'Functional polymer coatings for biointerface applications' 15.00-15.15 Coffee break 15.15-15.55 Prof. Dr. Tanja Weil: 'Supramolecular Biomaterials – From Molecular Design to Biomedical Applications' 16.00-16.40 Prof. Dr. Willem Mulder: 'Therapeutic regulation of innate immunity with nano biologics' 16.45-17.15 Closure of the afternoon section 17.15-18.00 Drink and networking moment with companies

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. B. MEIJER - CHAIRMAN OF THE DAY

Bert Meijer studied chemistry at the University of and obtained his master's degree in 1978. In 1982 he earned his PhD degree summa cum laude under supervision of Prof. Hans Wijnberg. In 1982 Meijer started working at the Philips Research Laboratories in Eindhoven and in 1989 he moved to DSM Research in Geleen. In 1991 he was installed as full professor of Organic Chemistry at the department for Chemical Engineering and Chemistry at the Eindhoven University of Technology (TU/e). In 1999 his chair was also established at the department for Biomedical Engineering. Since 2004 Bert Meijer is a distinguished university professor of Molecular Sciences at the TU/e. He founded the TU/e Institute for Complex Molecular Systems in 2008 and is now a co-director. Meijer is adjunct professor of Macromolecular Chemistry at Radboud University Nijmegen since 1994 and distinguished visiting professor at the University of California, Santa Barbara since 2008. In 2014 Bert Meijer was inducted as Academy Professor of the Royal Academy of Arts and Sciences. Since 2018 he is also an external member of the scientific staff of the Max-Planck Institute for Polymer Research in Mainz, Germany.

ABSTRACT

The synergy between nanotechnology and healthcare

For centuries, chemists have optimized the synthesis of the most useful molecular entities – from drugs to – and in a following step these molecules are processed into systems and materials to obtain the function they are designed for. Today, nanotechnology, , chemical biology, etc. offer great opportunities to optimize the creation of these complex molecular systems. For healthcare, it is regarded to be essential to close the gap between the dynamics of living tissue and that of artificial systems, devices and materials. After a short introduction of the field covered by the symposium, a few recent examples of our group will be presented.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. IR. J.C.M. VAN HEST

Jan van Hest obtained his PhD in macro-organic chemistry with professor Bert Meijer from Eindhoven University of Technology (TU/e) in 1996. He then worked as a postdoc researcher on protein engineering with professor David A. Tirrell at the University of Massachusetts. In 1997 van Hest started working at DSM (Geleen), first as a researcher and later as group head in the development of new material concepts. In 2000 Van Hest was appointed as full professor at Radboud University Nijmegen. As of September 2016 he holds the chair of Bio-organic Chemistry at TU/e. Over 30 PhD candidates have gained their doctorates under his supervision. He has published over 300 scientific articles (H-index 57) and is (co-)inventor of 17 patents and patent applications. Jan van Hest is also the joint founder of the start-ups Encapson, FutureChemistry, Noviosense and Noviotech.

ABSTRACT

Adaptive polymer assemblies for biomedical applications

Polymer-based assemblies have much application potential in the biomedical field. We have a special interest in constructing particles with adaptive features, which can change their properties when exposed to external stimuli. I will first present adaptive particles that can be used in photodynamic therapy (PDT). We have developed particles that, due to their adaptiveness, can improve this treatment. Secondly, I will discuss polymer-stabilized complex coacervates, which can be regarded as artificial cells. The crowdedness of the coacervate mimics the cytoplasm of living cells, whereas the polymer membrane is semi-permeable and allows exchange of molecules between the artificial cell and its environment. This opens opportunities for application in tissue engineering.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. ICMS

The Institute for Complex Molecular Systems at the TU/e creates an environment for inquisitive minds to address major research challenges and push the boundaries of science. We generate fundamental knowledge that accelerates innovation in the areas of Advanced Materials and Engineering Health. We achieve this by gaining a deeper understanding of the relationship between the structure, dynamics, processing, and functionality of complex molecular systems. Educating the next generation of scientists and bringing together top talent are at the heart of what we do. With over 240 researchers, ICMS combines expertise from across different disciplines to design and develop the next generation of materials – from self-cleaning coatings to smart heart valves. Our combination of cross-disciplinary expertise and a powerful toolbox of advanced analysis equipment enables our scientific excellence. Our research provides a unique source of new principles and concepts for industry that supports their competitive edge. Our Industrial Consortium provides partners with knowledge that secures their current innovations and creates new ones. Also, ICMS often creates research that leads to spin-off companies where original ideas are brought to commercial fruition. We seek to connect researchers, and to create and expand partnerships in academia, industry, and beyond in order to impact markets and society.

ABSTRACT

Unraveling complexity across the scales for new and advanced materials

Molecules constitute the material world around us – both natural and synthetic. Understanding complex molecular systems at the most fundamental level will enable us to shape the future of , energy, mobility, health, and even life itself. The science of complex molecular systems is therefore a major driving force for innovation and addressing our greatest industrial and societal challenges, as it promises the bottom-up design of new functional systems with tailored properties. This endeavour is at the heart of the research undertaken at the Institute for Complex Molecular Systems (ICMS). ICMS pushes for scientific excellence by unifying our researchers and basic principles of chemistry, biomedical sciences, engineering, physics and mathematics. This inter-disciplinary approach is combined with a powerful toolbox of advanced analysis techniques that enable our researchers to not only analyze the structure of materials, but also discover how structure evolves under changing conditions over time. Prof. Dr. Ir. Jan van Hest (ICMS Scientific Director) will navigate you through how applying this approach to fascinating scientific challenges opens the door to the design of the next generation of “smart” and advanced materials.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. ASPEN OSS BV - DR. DJ VAN ZOELEN

My name is DJ van Zoelen (44 years old). I am married to Germa van Zoelen and we live in Culemborg together with our five children. We moved there during my doctoral research at the Utrecht University in the group of Prof. Dr. R. Liskamp. After obtaining my degree I started working at the R&D department of the former Organon in 2006. After having had various jobs (Manager Chemical Engineering, Operations Manager, OPEX project Manager, Plant Manager) I am now Manager DTS. Together with my team we are responsible for the content side of our production processes as well as the development of new products.

ABSTRACT

Sustainability: from a more or less buzzword in the past to a fully integrated new lifestyle today.

Sustainability certainly applies to our company. Aspen Oss BV produces Active Pharmaceutical Ingredients (APIs) and we are changing our traditional production to more sustainable production. Part of this transformation involves new technology such as waste (water) treatment, flow technology or new synthetic methods. Another part is about new chemistry, such as the application of enzymes or the development of second generation processes. In this lecture we will give examples of the transformation Aspen Oss BV is going through to create a sustainable future.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. IR. M.E.J. VLEUGELS

In 2016, Marle received her BSc. Degree at Eindhoven University of Technology (TU/e) after a final bachelor’s project in the group of Prof. Dr. Bert Meijer. During this project she focused on the synthesis of single-chain polymeric nanoparticles with spin labels for surface water retardation studies. In 2017, Marle rejoined the group for my graduation project which was focused on the effect of crystallinity and dispersity on the self-assembly behavior of block copolymers in water. Afterwards she went to London to perform an internship at Spirogen, where she worked on the synthesis and conjugation of highly potent payloads for imaging of antibody drug conjugates. After obtaining her MSc. degree in spring 2019, she started as a PhD student in the group of Prof. Dr. Bert Meijer in April. The aim of her project is to gain a better understanding of multivalent binding in dynamic supramolecular systems.

ABSTRACT

Achieving precise control over nanostructures by full discreteness on the self-assembly of amphiphilic block copolymers

The accessibility of versatile and stable nanostructures of controllable size and morphology by self-assembly of block copolymers in solution is essential for biomedical applications. However, an intrinsic property of polymers is their dispersity while in nature polymers are discrete and sequence controlled. These highly controlled natural polymers, such as DNA and peptides, have a very well-defined three-dimensional structure and corresponding function. Drawing inspiration from nature, we investigate the effect of full discreteness on the self-assembly of amphiphilic block copolymers to achieve precise control over the formed nanostructures.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. IR. A.C. WAUTERS

Annelies Wauters received her MSc in Biomedical Engineering at the Eindhoven University of Technology (TU/e) in 2017. During her masters, she was enrolled in a summer internship at the University of California Santa Barbara (UCSB), and she participated in the Netherlands Research School of Chemical Biology and in the Top Sector Chemistry Student Competition. She graduated in the groups of Prof. Dr. Ir. Menno Prins and Prof. Dr. Ir. Luc Brunsveld, and finalized her master with an externship at Philips.

ABSTRACT

Artificial antigen-presenting cells for immunotherapy

In immunotherapy a patient’s immune system is modulated to elicit an active or suppressive response. Current approaches are time-consuming, costly and involve patient invasive procedures. In addition, translation of novel immunotherapies towards the clinic remain limited due to too low efficacy and high systemic toxicity. Precision nanomedicines have high potential to overcome these issues by in vivo cell specific targeting. During this project, we will focus on the development of artificial antigen-presenting cells (aAPCs), that can be used for T-cell modulation. Polymeric nanoparticles consisting of (biodegradable) block-co-polymers, so-called polymersomes, are interesting for this purpose as they can be easily functionalized via e.g. click chemistry. Moreover, their shape can be precisely tuned, varying from spherical, to discoidal or tubular. A high-aspect ratio shape has been described to be advantageous for the multivalent immune synapse formation between the APC and T-cell, as well as cell migration and phagocytic uptake. Different polymersome-shapes will be functionalized with various interaction molecules and they will be studied for their effect on ex vivo T-cell responses and possibly their in vivo performance. It is envisioned that this modular platform can be applied for immunotherapies including cancer (activation) or auto-immune diseases (suppression).

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. IR. Y. FOELEN

After obtaining a bachelor’s degree in chemistry at Universiteit Hasselt (Hasselt, Belgium) with a research project on pressure sensitive adhesives in collaboration with Nitto Europe, Yari chose to pursue a more application- oriented master's degree at TU Eindhoven where he enrolled in the molecular systems and materials chemistry track of the Chemical engineering department. For his graduation project in 2018, he characterized the mechanical deformation of light responsive liquid crystal bilayer films in the stimuli-responsive functional materials & devices (SFD) group, under the supervision of Marina Pilz Da Cunha MSc and Prof. Dr. Albert Schenning. After 5 months industrial internship working on automated of drug carriers and emulsion polymerization optimization at CSIRO (Melbourne, Australia), Yari completed his Master of Science degree. He currently works as a doctoral candidate in the SFD group of TU Eindhoven.

ABSTRACT

Liquid crystal technology applied in responsive functional materials.

Within the SFD group, we aspire to engineer on a nano level for macro level response. This talk will illustrate the role of liquid crystal molecules and their corresponding metaphases in applications such as responsive optical sensors and soft robots. Various properties of liquid crystals on nanoscale like optical birefringence, thermotropic orientational order and anisotropic thermal expansion facilitate stimuli-responsive functional macroscopic behavior. In combination with conventional polymer properties such as shape memory behavior, the scope of applications can be extended even further. The key philosophies behind these multi-disciplinary developments will be discussed on a basic level and provide a lot of food for thought!

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. P. DANKERS

Patricia Dankers is professor in Biomedical Materials & Chemistry. She studied chemistry in Nijmegen. Her PhD studies were performed at TU/e, on supramolecular biomaterials (2006). She worked for SupraPolix, and the University Medical Center, Groningen. Her second PhD work was performed in medical sciences on kidney regenerative medicine, in Groningen (2013). She worked at Northwestern University, Chicago (2010). She climbed every step on the academic ladder, starting in 2008, ending in 2017 as full professor. She received Veni, Vidi (2008, 2017) and ERC starting, ERC PoC (2012, 2017) grants. She has recently been awarded the KNCV Gold Medal (2020).

ABSTRACT

Synthetic extracellular matrices based on supramolecular materials

The extracellular matrix (ECM) is a complex assembly of various molecules held together via both covalent and noncovalent interactions. In order to make materials with comparable properties it is proposed that supramolecular materials based on hydrogen bonding units are eminently suitable. An important challenge in the synthesis and formulation of synthetic extracellular matrices is the introduction of complexity. The bioactivity we have introduced into our supramolecular systems is based on small synthetic peptides, large ECM proteins, carbohydrates or decellularized ECM. Interestingly, small synthetic peptides can outperform mixtures of a large amount of different bioactive compounds, highlighting the importance of simple synthetic systems.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. R. HAAG

Rainer Haag is Professor of Organic and Macromolecular Chemistry at Freie Universität Berlin. Since 2008 he has been head of the Collaborative Research Center SFB 765 "Multivalence as Chemical Organization and Action Principlef ". His research interests include dendritic polymers as highly functional polymer carriers for catalysis, macromolecular nanotransporters for DNA and drug delivery, and protein-resistant material surfaces. In 2004, his group received the NanoFutur researcher award of the Federal Ministry of Science and Research (BMBF). Together with the start-up company Dendropharm, he received the Berlin-Brandenburg Innovation Award in 2016. Since 2019 he is an elected member of the German Academy of Science and Engineering (Acatech).

ABSTRACT

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Germany

A new “adsorption-cross-linking” technology is presented to generate a highly dense polymer brush coating on various nonpolar substrates, including the most inert and low-energy surfaces of PDMS and PTFE. This prospective surface modification strategy is based on a tailored bifunctional amphiphilic block copolymer with benzophenone units as the hydrophobic anchor/chemical cross-linker and terminal azide groups for in situ postmodification. The resulting polymer brushes exhibited long-term and ultralow protein adsorption and cell adhesion benefiting from the high density and high hydration ability of polyglycerol blocks. The presented antifouling brushes provided a highly stable and robust bioinert background for biospecific adsorption of desired proteins and cells after secondary modification with bioactive ligands.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. T. WEIL

Tanja Weil joined the Max Planck Society in 2017 as one of the directors of the Max Planck Institute for Polymer Research, heading the division “Synthesis of ”. She studied chemistry (1993–1998) at the TU Braunschweig (Germany) and the University of Bordeaux (France) and completed her PhD at the MPI for Polymer Research under the supervision of K. Müllen. In 2003, she received the Otto Hahn Medal of the Max Planck Society. From 2002 to 2008 she managed different leading positions at Merz Pharmaceuticals GmbH (Frankfurt) from Section Head Medicinal Chemistry to Director of Chemical Research and Development. In 2008 she accepted an Associate Professor position at the National University of Singapore and in 2010 she joined Ulm University as Director of the Institute of Organic Chemistry III / Macromolecular Chemistry. She is a member of the senate of the German Research Foundation, the senate of the Leibniz Association and of the Leibniz evaluation panel. Tanja is an associate editor for ACS Nano, a member of the editorial advisory board of J. Am. Chem. Soc. and of the Kuratorium of Angewandte Chemie. Her scientific interests focus on innovative synthesis concepts to achieve functional macromolecules and hybrid materials to solve current challenges in biomedicine and material science.

ABSTRACT

Supramolecular Biomaterials – From Molecular Design to Biomedical Applications

The extracellular matrix (EM) forms a complex, supportive environment for cells providing mechanical and biochemical cues, and enabling cells to communicate. Evolution has created these unique heterogeneous matrices with inner structure and various functional entities that control e.g. pathogen binding and stimulate cell growth and division. We focus on the synthesis of peptide-polymer biomaterials that can serve as synthetic EM-mimicking environments by forming 3D fibril networks or soft polymers with inner fibril structure. Rational optimization of monomer sequences and fibril morphologies facilitated dynamic supramolecular networks supporting neuronal cells growth in vitro and vivo as well as pathogen binding. Responsiveness towards various stimuli such as pH changes, light and reactive oxygen species was implemented at the molecular level into the biopolymer sequences. In this way, materials properties were optimized towards enhanced bioactivity and customized for their respective microenvironments for e.g. local drug delivery, which offers new avenues for cancer therapy, cell and tissue engineering.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. W.J.M. MULDER

Willem Mulder obtained his MSc in Chemistry from Utrecht University (the Netherlands) in 2001 and his PhD in Biomedical Engineering from Eindhoven University of Technology (TU/e, the Netherlands) in 2006. Thereafter, he was appointed assistant professor of Radiology at Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine at Mount Sinai, New York, USA) where he founded the Nanomedicine Laboratory. In 2012 he was appointed associate professor and in 2016 full professor of Radiology at Mount Sinai. In 2013, he received a Vidi grant by the Netherlands Organisation of Scientific Research (NWO) and was appointed as part-time professor of ‘Cardiovascular Nanomedicine' at the Academic Medical Center of the University of Amsterdam. In 2018, he was awarded a 1.5 million euro Vici grant by the Netherlands Organisation of Scientific Research NWO. He then moved to Eindhoven University of Technology (TU/e) to start his research group as professor of Precision Medicine at the TU/e department of Biomedical Engineering.

ABSTRACT

Therapeutic regulation of innate immunity with nanobiologics

Immunotherapy is revolutionizing the treatment of diseases. Most of the immunotherapy strategies currently being developed engage the adaptive immune system. In recent years, emerging evidence has shown that the innate immune system displays long-term changes in its functional program through metabolic and epigenetic programming of myeloid cells (monocytes, macrophages, dendritic cells). Therefore, targeting myeloid cells and their progenitors is a powerful ‘therapeutic framework’ to regulate the delicate balance of immune homeostasis, priming/training and tolerance. This Presentation will showcase how nanobiologic-based immunotherapies can be applied to achieve long-term therapeutic benefits in detrimental diseases, including cancer and cardiovascular diseases as well as to prevent organ rejection after transplantation. In addition, a translational workflow involving innovative multimodality imaging approaches and large animal models will be discussed.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. VSI/E ARTICLE

The Vereniging of Scheikundige Ingenieurs Eindhoven (VSI/e) was founded in 1994, and counts at the moment approximately 500 members. Our most important goal is to enhance the network between engineers from Eindhoven and to connect the graduates with the TU/e and chemical faculty. The value of this network for our members is big, both in a professional as a personal sense. Members of our association are informed about the ins and outs of our faculty and they can meet each other during reunions, lectures, or our annual general membership meeting. The VSI/e represents chemical engineers who have studied Chemical Engineering and Chemistry at the TU/e. More information can be found on our website: www.vsi-eindhoven.nl

COMMITTEE OF RECOMMENDATION

Prof. Dr. Ir. Frank Baaijens Mr. Baaijens is the rector of the Eindhoven University of Technology

John Jorritsma Mr. Jorritsma is the mayor of the municipality of Eindhoven.

Prof. Dr. Ben Feringa Mr. Feringa is the Nobel Prize in Chemistry laureate of 2016. He is professor at the and performs research into nanomotors.

Prof. Dr. Ir. Emiel Hensen Mr. Hensen is the former dean of the faculty of chemical engineering and chemistry.

Prof. Dr. Maarten Merkx Mr. Merkx is the dean of the faculty of biomedical engineering.

Prof. Dr. Jeroen Cornelissen Mr. Cornelissen is the president of the Royal Dutch Chemistry Society (KNCV)

Ir. Joanne Meyboom-Fernhout Mrs. Meyboom-Fernhout is the president of the Royal Institute of Engineers (KIVI)

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. COMMITTEE

Japie-Protagoras Symposium Committee 2021. This years committee is formed by both members of T.S.V. 'Jan Pieter Minckelers’ (Japie) and SvBMT Protagoras (Protagoras).

Lisa Cattenstart - Japie Chairman

Tom Bruining - Japie Secretary

Jo-Anne Ewald - Protagoras Treasurer

Ruben Jetten - Japie Commissioner of External Affairs

Sanne van de Vorst - Protagoras Public Relations

Werner Doensen - Protagoras Event Planner

ORGANIZATION

Study association T.S.V. ‘Jan Pieter Minckelers’, commonly abbreviated as ‘Japie’, is the study association of the department of Chemical Engineering and Chemistry at the Eindhoven University of Technology. Japie has the goal to strengthen the education at the department by giving the students the opportunity to give their feedback, provide recreational activities for its members and give the members the chance to develop themselves by organizing various events. Japie also focuses on preparing its members for their professional career by visits to industrial plants and by organizing lectures given by chemical companies.

SvBMT Protagoras is the study association of the department of Biomedical Engineering at the Eindhoven University of Technology. Protagoras takes care of education, experience and entertainment by providing study materials and feedback for the department, organizing excursions, lectures and symposia, and by organizing drinks and other activities. The goal of Protagoras is in line with the objective of the study Biomedical Engineering: to train engineers who can apply advanced engineering in the most intriguing system comprising the human being.

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. AKNOWLEDGEMENTS

This symposium is organized by T.S.V. 'Jan Pieter Minckelers’ and SvBMT Protagoras. The organizing committee would like to give special thanks to those (in)directly involved in the organization of the symposium. First of all we would like to thank the 62nd and 63rd boards of T.S.V. ‘Jan Pieter Minckelers’ and the 31st and 32nd boards of SvBMT Protagoras for helping us throughout the organization of the symposium and handling the financial transactions. Special thanks goes to Prof. Dr. Bert Meijer, for taking the role of chairman during the symposium and for his advice in the organization. Furthermore, we would like to thank all the speakers who presented their work: Prof. Dr. Ir. Jan van Hest, Dr. DJ van Zoelen, Ir. Marle Vleugels, Ir. Annelies Wouters, Ir. Yari Foelen, Prof. Dr. Patricia Dankers, Prof. Dr. Rainer Haag, Prof. Dr. Tanja Weil and Prof. Dr. Willem Mulder. Our appreciation also goes to ICMS, Aspen Oss BV, KNCV-VNCI, Stichting Universiteitsfonds Eindhoven (UF/e), Stichting Hoogewerff Fonds, SyMO- Chem BV, VSI/e and Pharming for offering us a financial support to organize the symposium, as well as the Department of Chemical Engineering and Chemistry and the Department of Biomedical Engineering. Moreover, we would like to thank the committee of recommendation for supporting our symposium. Gratitude to all the teachers who helped us in promoting the symposium by allowing us to give promotional talks and put announcements on Canvas. We thank OpenWebcast for enabling the symposium to take place in an online environment. Our appreciation also goes out to all the people that in one way or another contributed in the realization of the symposium. And of course thanks to all the participants of the symposium and a warm thanks to all the members of the symposium committee who worked hard to make the symposium happen.

NOTES

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. NOTES

NOTES

For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. Proceedings of Symposium "A BIG small world" Held on 9th of february, 2021 at Eindhoven University of Technology

Writers: T.S.V. 'Jan Pieter Minckelers' and SvBMT Protagoras T.S.V. 'Jan Pieter Minckelers' SvBMT Protagoras Eindhoven, University of Technology Eindhoven, University of Technology Helix STW 0.25 Den Dolech 2 Postbus 513 Gemini-Noord 1.60 5600 MB Eindhoven 5600 MB Eindhoven Tel.: 040-247 3756 Tel.: 040-247 2758 E: [email protected] E: [email protected] W: www.tsvjapie.nl W: www.protagoras.tue.nl

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