A BIG SMALL WORLD Symposium 2021 FEBRUARY 9, 2021 | 8.45 A.M. Joint online symposium between the study associations T.S.V. 'Jan Pieter Minckelers' and SvBMT Protagoras of respectively the faculties of chemical engineering and chemistry and biomedical engineering! SPONSORS PREFACE Dear participant, On behalf of the Japie-Protagoras Symposium Committee I would like to welcome you to the symposium ‘A BIG Small World’. Nanotechnology, the manipulation of matter on an atomic, molecular and supramolecular scale, has been a large topic of interest in research lately. In healthcare, nanotechnology holds immense potential, from improved disease diagnosis to drug delivery by customizing molecular systems. During the symposium the subject of nanotechnology in healthcare will be viewed from different angles. Examples of questions that will be answered are: Can diseases like cancer be treated better using the latest advancements in nanotechnology? Can synthetic polymer complexes serve as artificial cells? Can the extracellular matrix be mimicked by synthetic supramolecular materials? How can the production of active pharmaceutical ingredients be improved by developing new chemistries and optimizing flow technology? How can liquid crystals be used to create optical sensors for medical applications? How can nanotechnology be used to improve functional polymer coatings for bio interface applications? Although this symposium will be held online, we would like to involve the participants as much as possible. There will be a possibility to ask questions after each lecture and during the lunch break and after the lectures there will be plenty of room to get to know the companies and discuss the research of our speakers during the (virtual) drink. With this symposium we hope to motivate young scientists to change the world at the smallest scale! We wish you an inspiring and pleasant day! On behalf of the Japie-Protagoras Symposium Committee 2021, Lisa Cattenstart Chairman For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. CONTENT Program 5 Chaiman of the day 6 Prof. Dr. Ir. Jan van Hest 8 ICMS: Prof. Dr. Ir. Jan van Hest 10 Aspen Oss BV: Dr. DJ van Zoelen 12 Ir. Marle Vleugels 14 Ir. Annelies Wauters 16 Ir. Y. Foelen 18 Prof. Dr. Patricia Dankers 20 Prof. Dr. Rainer Haag 22 Prof. Dr. Tanja Weil 24 Prof. Dr. Willem Mulder 26 VSI/e 28 Committee of recomendation 29 Committee 30 Organisation 31 Aknowledgements 32 PROGRAM 08.15-08.45 Welcoming of guests 08.45-09.15 Opening of the symposium by Committee chairman Lisa Cattenstart and chairman of the day Prof. Dr. Bert Meijer 09.15-09.55 Prof. Dr. Ir. Jan van Hest: 'Adaptive polymer assemblies for biomedical applications' 10.00-10.40 ICMS, Prof. Dr. Ir. Jan van Hest: 'How to apply an interdisciplinary approach with powerful toolboxes of advanced analysis techniques to fascinating scientific challenges for the next generation of “smart” and advanced materials.' 10.45-11.00 Coffee break 11.00-11.40 Aspen Oss BV, Dr. DJ van Zoelen: 'Sustainability in API production: from a more or less buzzword in the past to a fully integrated new lifestyle today' 11.45-12.25 PhD presentations 12.35-12.45 Closure of the morning section 12.45-13.30 Lunch 13.30-14.10 Prof. Dr. Patricia Dankers: 'Synthetic extracellular matrices based on supramolecular materials' 14.15-14.55 Prof. Dr. Rainer Haag: 'Functional polymer coatings for biointerface applications' 15.00-15.15 Coffee break 15.15-15.55 Prof. Dr. Tanja Weil: 'Supramolecular Biomaterials – From Molecular Design to Biomedical Applications' 16.00-16.40 Prof. Dr. Willem Mulder: 'Therapeutic regulation of innate immunity with nano biologics' 16.45-17.15 Closure of the afternoon section 17.15-18.00 Drink and networking moment with companies For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. B. MEIJER - CHAIRMAN OF THE DAY Bert Meijer studied chemistry at the University of Groningen and obtained his master's degree in 1978. In 1982 he earned his PhD degree summa cum laude under supervision of Prof. Hans Wijnberg. In 1982 Meijer started working at the Philips Research Laboratories in Eindhoven and in 1989 he moved to DSM Research in Geleen. In 1991 he was installed as full professor of Organic Chemistry at the department for Chemical Engineering and Chemistry at the Eindhoven University of Technology (TU/e). In 1999 his chair was also established at the department for Biomedical Engineering. Since 2004 Bert Meijer is a distinguished university professor of Molecular Sciences at the TU/e. He founded the TU/e Institute for Complex Molecular Systems in 2008 and is now a co-director. Meijer is adjunct professor of Macromolecular Chemistry at Radboud University Nijmegen since 1994 and distinguished visiting professor at the University of California, Santa Barbara since 2008. In 2014 Bert Meijer was inducted as Academy Professor of the Royal Netherlands Academy of Arts and Sciences. Since 2018 he is also an external member of the scientific staff of the Max-Planck Institute for Polymer Research in Mainz, Germany. ABSTRACT The synergy between nanotechnology and healthcare For centuries, chemists have optimized the synthesis of the most useful molecular entities – from drugs to polymers – and in a following step these molecules are processed into systems and materials to obtain the function they are designed for. Today, nanotechnology, supramolecular chemistry, chemical biology, etc. offer great opportunities to optimize the creation of these complex molecular systems. For healthcare, it is regarded to be essential to close the gap between the dynamics of living tissue and that of artificial systems, devices and materials. After a short introduction of the field covered by the symposium, a few recent examples of our group will be presented. For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. PROF. DR. IR. J.C.M. VAN HEST Jan van Hest obtained his PhD in macro-organic chemistry with professor Bert Meijer from Eindhoven University of Technology (TU/e) in 1996. He then worked as a postdoc researcher on protein engineering with professor David A. Tirrell at the University of Massachusetts. In 1997 van Hest started working at DSM (Geleen), first as a researcher and later as group head in the development of new material concepts. In 2000 Van Hest was appointed as full professor at Radboud University Nijmegen. As of September 2016 he holds the chair of Bio-organic Chemistry at TU/e. Over 30 PhD candidates have gained their doctorates under his supervision. He has published over 300 scientific articles (H-index 57) and is (co-)inventor of 17 patents and patent applications. Jan van Hest is also the joint founder of the start-ups Encapson, FutureChemistry, Noviosense and Noviotech. ABSTRACT Adaptive polymer assemblies for biomedical applications Polymer-based assemblies have much application potential in the biomedical field. We have a special interest in constructing particles with adaptive features, which can change their properties when exposed to external stimuli. I will first present adaptive particles that can be used in photodynamic therapy (PDT). We have developed particles that, due to their adaptiveness, can improve this treatment. Secondly, I will discuss polymer-stabilized complex coacervates, which can be regarded as artificial cells. The crowdedness of the coacervate mimics the cytoplasm of living cells, whereas the polymer membrane is semi-permeable and allows exchange of molecules between the artificial cell and its environment. This opens opportunities for application in tissue engineering. For more details about this event, visit our website at https://symposium.tsvjapie.nl. For inquiries mail at [email protected]. ICMS The Institute for Complex Molecular Systems at the TU/e creates an environment for inquisitive minds to address major research challenges and push the boundaries of science. We generate fundamental knowledge that accelerates innovation in the areas of Advanced Materials and Engineering Health. We achieve this by gaining a deeper understanding of the relationship between the structure, dynamics, processing, and functionality of complex molecular systems. Educating the next generation of scientists and bringing together top talent are at the heart of what we do. With over 240 researchers, ICMS combines expertise from across different disciplines to design and develop the next generation of materials – from self-cleaning coatings to smart heart valves. Our combination of cross-disciplinary expertise and a powerful toolbox of advanced analysis equipment enables our scientific excellence. Our research provides a unique source of new principles and concepts for industry that supports their competitive edge. Our Industrial Consortium provides partners with knowledge that secures their current innovations and creates new ones. Also, ICMS often creates research that leads to spin-off companies where original ideas are brought to commercial fruition. We seek to connect researchers, and to create and expand partnerships in academia, industry, and beyond in order to impact markets and society. ABSTRACT Unraveling complexity across the scales for new and advanced materials Molecules constitute the material world around us – both natural and synthetic. Understanding complex molecular systems at the most fundamental level will enable us to shape the future of materials science, energy, mobility, health, and even life itself. The science of complex molecular systems is therefore a major driving force for innovation and addressing our greatest industrial and societal challenges, as it promises the bottom-up design of new functional systems with tailored properties. This endeavour is at the heart of the research undertaken at the Institute for Complex Molecular Systems (ICMS). ICMS pushes for scientific excellence by unifying our researchers and basic principles of chemistry, biomedical sciences, engineering, physics and mathematics.