Construction and Characterization of Hybrid
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Stimuli-Responsive Polymersomes and Nanoreactors
Stimuli-responsive polymersomes and nanoreactors Citation for published version (APA): Che, H., & van Hest, J. C. M. (2016). Stimuli-responsive polymersomes and nanoreactors. Journal of Materials Chemistry B, 4(27), 4632-4647 . https://doi.org/10.1039/C6TB01163B DOI: 10.1039/C6TB01163B Document status and date: Published: 17/07/2016 Document Version: Accepted manuscript including changes made at the peer-review stage Please check the document version of this publication: • A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. -
Dendronized Poly(2-Oxazoline) Displays Within Only Five Monomer Repeat Units Liquid Quasicrystal, A15 and Σ Frank−Kasper Phases † † ⊥ † † ‡ § Marian N
Communication Cite This: J. Am. Chem. Soc. 2018, 140, 16941−16947 pubs.acs.org/JACS Dendronized Poly(2-oxazoline) Displays within only Five Monomer Repeat Units Liquid Quasicrystal, A15 and σ Frank−Kasper Phases † † ⊥ † † ‡ § Marian N. Holerca, Dipankar Sahoo, , Benjamin E. Partridge, Mihai Peterca, , Xiangbing Zeng, § ∥ † Goran Ungar, , and Virgil Percec*, † Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States ‡ Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6396, United States § Department of Materials Science and Engineering, University of Sheffield, Sheffield S1 3JD, United Kingdom ∥ State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China *S Supporting Information discovered for self-assembling dendrons a few years later.2f ABSTRACT: Liquid quasicrystals (LQC) have been Subsequently, these three periodic and quasiperiodic arrays,10 discovered in self-assembling benzyl ether, biphenylmeth- and additional Frank−Kasper phases including the C14 and C15 yl ether, phenylpropyl ether, biphenylpropyl ether and Laves phases,11 have been transplanted to other types of soft some of their hybrid dendrons and subsequently in block matter12,13 including block copolymers,11b,14 lyotropic surfac- copolymers, surfactants and other assemblies. These tants,15 lipids and glycolipids,16 colloidal nanocrystals,17 and quasiperiodic arrays, which lack long-range translational molecules based on silsesquioxane cages.18 Frank−Kasper periodicity, are approximated by two Frank−Kasper phases and quasicrystals generated from soft matter have been periodic arrays, Pm3̅n cubic (Frank−Kasper A15) and subjected to various theoretical investigations that have − σ P42/mnm tetragonal (Frank Kasper ), which have been examined the energetic and entropic basis for their forma- discovered in complex soft matter in the same order and tion.9c,10,19 compounds. -
Curriculum Vitae KRISTI L
Curriculum Vitae KRISTI L. KIICK, PH.D. Professor www.udel.edu/mseg Department of Materials Science and Engineering [email protected] Biomedical Engineering 302 831 0201 University of Delaware, Newark, DE 19716 EDUCATION Doctor of Philosophy Polymer Science and Engineering 2001 University of Massachusetts Amherst, Amherst, MA NDSEG Predoctoral Fellow Master of Science Polymer Science and Engineering 1998 University of Massachusetts Amherst , Amherst, MA Master of Science Chemistry 1991 University of Georgia, Athens, GA NSF Predoctoral Fellow Bachelor of Science Chemistry, Summa cum laude 1989 University of Delaware, Newark, DE Eugene duPont Memorial Scholar RESEARCH INTERESTS Biologically derived methods for the synthesis and assembly of advanced macromolecular materials The development of protein engineering methods for the synthesis of artificial protein polymers functionalized with both natural and non-natural amino acids, and the chemical modification of protein polymers to produce well-defined protein-based architectures. The use of modified proteins in both biological and materials applications such as toxin neutralization, manipulation of cell signaling, and construction of light-emitting devices. The development of new elastomeric materials with well-defined conformational and assembly behavior. The assembly of hydrogel networks via protein-polysaccharide interactions to produce materials that mimic the biological activity of the extracellular matrix and that have controlled mechanical, erosion, and drug delivery properties. The -
LIQUID CRYSTAL NEWSLIQUID NEWS $(%(&' "!!#$(%(&'"!!# GW Gray Medal for 2006 Professor Heino Finkelmann
LIQUID CRYSTAL NEWSLIQUID NEWS $(%(&' "!!#$(%(&'"!!# GW Gray Medal for 2006 Professor Heino Finkelmann as originally intended in Krakow. Since these days, we have met very frequently, for example, when I was privileged to lecture in Professor Finkelmann’s Institute and at many other scientific meetings not least of which was the Twelfth International Liquid Crystal Conference held in 1988 in Freiburg itself and chaired and organised by Professor Finkelmann. My wife and I well remember enjoying a glass of wine with Heino and his wife and two boys at their home after the closing ceremonies were complete and people like conference chairmen are at last allowed to relax. I have put the material in the above paragraph early in this article about Heino Finkelmann, because I wanted to stress that his very great contributions to the subject of liquid crystals have been not only in the area of scientific research, but also, by his readiness to travel far and wide to Heino Finkelmann was born in Gronau in Lower give lectures, by spreading the word on the subject, by Saxony in 1945. After school, his studies at the Scientific serving on the editorial boards of relevant journals, by Technical Academy at Isny were in the field of chemical organising meetings and conferences such as the 12th engineering and on the way to qualifying in 1969, he spent ILCC, by serving as he has twice done on the Board of time with Unilever Research and with British Petroleum in Directors of the International Liquid Crystal Society and by Hamburg. He then studied Chemistry at the Technical acting as Chairman of the German Liquid Crystal Society University of Berlin, and it was here that he first began as he did for many years. -
Marc Antoniu Ilies
Curriculum Vitae MARC A. ILIES, Ph. D. ____________________________________________________________________________________________________________________ Office Address: Home address: Temple University School of Pharmacy 2616 Parrish Street Department of Pharmaceutical Sciences Philadelphia, PA-19130 3307 North Broad Street, Suite 517 Philadelphia, PA-19140 Phone: 215-707-1749 ; Fax: 215-707-5620 Email: [email protected] PRESENT POSITION: Professor Director of the NMR facilities of TU School of Pharmacy Member of the Moulder Center for Drug Discovery Research, TUSP Collaborating member of Temple Fox Chase Cancer Center Molecular Therapeutics Program and Imaging Consortium EDUCATION NRSA/NIH Postdoctoral fellow, University of Pennsylvania Health System, Department of Pharmacology (2006-2007); Mentors: Professors Vladimir Muzykantov and Ian Blair Postdoctoral fellow, University of Pennsylvania, Department of Chemistry (2004- 2006); Mentor: Professor Virgil Percec Welch postdoctoral fellow, Texas A&M University, Galveston, TX, and Visiting scientist, University of Texas Medical Branch at Galveston, TX; (2001-2004); Mentors: Professors Alexandru T. Balaban, William A. Seitz, and E. Brad Thompson Ph. D., Chemistry, University “Politehnica” Bucharest, Romania, 2001 Thesis title: “Novel pyrylium and pyridinium salts with biological activity” Adviser: Professor Alexandru T. Balaban F. Rom. Acad. Sci. (presently Professor at Texas A&M University at Galveston, Galveston, TX) M. S., Chemistry, University of Bucharest, Bucharest, Romania, 1996 -
ESR 6 Project Information Sheet
ESR 6 Project Information Sheet Project Title Nanomotor-based cell targeting and sorting Reference number BIOMOLMACS_ESR_6 Host Institution/Company Eindhoven University of Technology Supervisor(s) Prof. Jan van Hest Research Group Bio-organic chemistry group Department/School Department of Chemical Engineering and Chemistry Duration 36-months full-time employment contract provided and ESR enrolled on 4- year structured PhD. The fourth year will be provided by Eindhoven University of Technology Funding information Funding agency: H2020-MSCA-ITN-2019 (Proposal no:859416) Early Stage Researcher Salary Living allowance: approximately €40,000/year + mobility allowance of and Allowances €7,200/year + family allowance where applicable (all values before tax and social security payments) This calculation is to give you an idea about the level of funding. The actual salaries can be found on the official job application link below. Pre-application closing date 28th of February 2020 Official application closing date 15th of March 2020 Start date 1st of April 2020 or as soon as possible thereafter. Official job application link* https://www.academictransfer.nl https://jobs.tue.nl/nl/vacatures.html *The pre-application form should be submitted to [email protected] by latest 28th of February 2020. Following the initial eligibility assessment, the applicants will be requested to submit their applications using the links provided specific to each institution/company. 1 Post Summary Brief description of the project: The main focus of this project will be to develop nanomotors based on polymer vesicles that can recognize, bind and isolate specific cells. Bowl-shaped vesicles, also known as stomatocytes, will be created out of biodegradable block copolymers prepared from poly(ethylene glycol)-poly(D,L- lactic acid) and loaded with enzymes, specifically glucose oxidase and catalase. -
PDF Hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/161485 Please be advised that this information was generated on 2017-12-06 and may be subject to change. Engineering compartmentalised life-like molecular systems Marlies Nijemeisland Engineering compartmentalised life-like molecular systems Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van de rector magnificus prof. dr. J.H.J.M. van Krieken, volgens besluit van het college van decanen in het openbaar te verdedigen op donderdag 12 januari 2017 om 12.30 uur precies door Marlies Nijemeisland geboren op 22 september 1984 te Zelhem Promotoren: Prof. dr. ir. Jan C.M. van Hest Prof. dr. Wilhelm T.S. Huck Manuscriptcommissie: Prof. dr. Roeland J.M. Nolte (voorzitter) Prof. dr. Jan H. van Esch (Technische Universiteit Delft) Dr. ir. Tom F.A. de Greef (Technische Universiteit Eindhoven) ISBN: 978-94-92380-06-7 © 2016 Marlies Nijemeisland This work was financially supported by the Radboud University (Bionic Cell project), the Ministry of Education, Culture and Science (Gravitation program 024.001.035) and funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-20012)/ERC- StG 307679 “StomaMotors”. Cover design: Ria Nijemeisland-Heusinkveld Press: Gildeprint Table of Contents Chapter 1 General introduction and thesis outline ......................................... 1 1.1 Introduction ........................................................................................... 2 1.2 Compartments ........................................................................................ 2 1.2.1 Membrane vesicles ....................................................................... 3 1.2.2 Multi-compartment systems ........................................................ -
Artificial Cells: Synthetic Compartments with Life-Like Functionality and Adaptivity
This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. Article pubs.acs.org/accounts Artificial Cells: Synthetic Compartments with Life-like Functionality and Adaptivity Bastiaan C. Buddingh’ and Jan C. M. van Hest* Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands CONSPECTUS: Cells are highly advanced microreactors that form the basis of all life. Their fascinating complexity has inspired scientists to create analogs from synthetic and natural components using a bottom-up approach. The ultimate goal here is to assemble a fully man-made cell that displays functionality and adaptivity as advanced as that found in nature, which will not only provide insight into the fundamental processes in natural cells but also pave the way for new applications of such artificial cells. In this Account, we highlight our recent work and that of others on the construction of artificial cells. First, we will introduce the key features that characterize a living system; next, we will discuss how these have been imitated in artificial cells. First, compartmentalization is crucial to separate the inner chemical milieu from the external environment. Current state-of-the-art artificial cells comprise subcompartments to mimic the hierarchical architecture of eukaryotic cells and tissue. Furthermore, synthetic gene circuits have been used to encode genetic information that creates complex behavior like pulses or feedback. Additionally, artificial cells have to reproduce to maintain a population. -
Shedding the Hydrophilic Mantle of Polymersomes
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/100612 Please be advised that this information was generated on 2021-10-03 and may be subject to change. Polymeric vesicles for drug delivery over the blood-brain barrier and in vivo Imaging René Pascal Brinkhuis Polymeric vesicles for drug delivery over the blood-brain barrier and in vivo imaging Een wetenschappelijke proeve op het gebied van de Natuurwetenschappen, Wiskunde en Informatica Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van de rector magnificus prof. mr. S.C.J.J. Kortmann, volgens besluit van het college van decanen in het openbaar te verdedigen op maandag 10 december 2012 om 13.30 uur precies door René Pascal Brinkhuis geboren op 11 april 1981 te Deventer Promotoren: Prof. dr. ir. J.C.M. van Hest Prof. dr. F.P.J.T. Rutjes Manusscriptcommissie: Prof. dr. R.J.M. Nolte Prof. dr. D. Hoekstra (UMC Groningen) Prof. dr. O.C. Boerman (UMC Nijmegen) Druk: Ipskamp drukkers B.V., Enschede ISBN: 978-90-9027254-2 Contents Contents ............................................................................................................................................................................. 3 Preface .............................................................................................................................................................................. -
Meet the Editorial Board DOI: 10.1039/C001033m
PROFILE www.rsc.org/polymers | Polymer Chemistry Meet the Editorial Board DOI: 10.1039/c001033m Professor David Haddleton, for Polymer Research, obtaining her PhD a Member of the Chinese Academy of Editor-in-Chief in 1998 for work in the area of fullerene Sciences. adducts and polymers. A postdoctoral Professor Academician Yang was fellowship with CPIMA (NSF-Center for a faculty member of Fudan University Polymer Interfaces and Macromolecular before he was appointed Vice President Assemblies) brought her to the IBM for Research in 1999. In 2006, he was Almaden Research Center, California appointed Director General of the USA, to work under the direction of Prof. Department of Degree and Postgraduate Craig J. Hawker focusing on the devel- Education, State Council of the People’s opment of new living free polymerization Republic of China. Professor Academi- techniques and approaches to nanoscopic cian Yang serves as senior advisor to the materials. In 2001 she joined XenoPort, Shanghai Municipal Government. He Inc. as a Staff Scientist investigating was inaugurated as President of Fudan enabling technologies for the increased University in January 2009. bioavailability of macromolecular thera- The academic interests of Professor peutics. After this extensive industrial Academician Yang are in condensed experience she started at Vanderbilt matter physics and polymer science. He David Haddleton is Professor of Chem- University as Assistant Professor in the owns many domestic and international istry at the University of Warwick, UK. Department of Chemistry in 2004 with patents and serves on the boards of Professor Haddleton’s research centres a secondary appointment in the Depart- several academic journals including on controlled polymerisation to give ment of Pharmacology, Vanderbilt Chinese Journal of Chemistry and Science macromolecules of designed, desired and Medical School. -
Bioconjugate Chemistry主编 Prof
Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety 中科院纳米生物效应与安全性重点实验室 学术报告通知 CAS NS Forum (NO. 328) 演讲者: Prof. Vince Rotello, University of Massachusetts-Amherst, Bioconjugate Chemistry主编 Prof. Jan van Hest, Radboud University Nijmegen (The Netherlands) Bioconjugate Chemistry副主编 Prof. Gang Zheng, University of Toronto, Bioconjugate Chemistry副主编 Prof. Bradley D. Smith, University of Notre Dame, Baltimore County Bioconjugate Chemistry副主编 Prof. Erin Lavik, University of Maryland, Bioconjugate Chemistry副主编 时 间: 2019年10月21日 (星期一) 10:00 地 点: 国家纳米科学中心,南楼二层多功能厅 主持人: 陈春英 研究员 简 介: Vincent Rotello is the Charles A. Goessmann Professor of Chemistry and a University Distinguished Professor at the University of Massachusetts at Amherst. He received his B.S. in Chemistry in 1985 from Illinois Institute of Technology, and his Ph. D. in 1990 in Chemistry from Yale University. He was an NSF postdoctoral fellow at Massachusetts Institute of Technology from 1990-1993, and joined the faculty at the University of Massachusetts in 1993. He has been the recipient of the NSF CAREER and Cottrell Scholar awards, as well as the Camille Dreyfus Teacher- Scholar, the Sloan Fellowships. More recently, he has received the Langmuir Lectureship (2010), and in 2016 he received the Transformational Research and Excellence in Education Award presented by Research Corporation, the Bioorganic Lectureship of the Royal Society of Chemistry (UK), the Australian Nanotechnology Network Traveling Fellowship, and the Chinese Academy of Sciences, President's International Fellowship for Distinguished Researchers. He is a Fellow of both the American Association for the Advancement of Science (AAAS) and of the Royal Society of Chemistry (U.K.). He is also recognized in 2014, 2015 and 2018 by Thomson Reuters/Clarivate as “Highly Cited Researcher”. -
Curriculum Vitae MARC A
Curriculum Vitae MARC A. ILIES, Ph. D. ____________________________________________________________________________________________________________________ Office Address: Home address: Temple University School of Pharmacy 2616 Parrish Street Department of Pharmaceutical Sciences Philadelphia, PA-19130 3307 North Broad Street, Suite 517 Philadelphia, PA-19140 Phone: 215-707-1749 ; Fax: 215-707-5620 Email: [email protected] PRESENT POSITION: Associate Professor Director of the NMR facilities of TU School of Pharmacy Member of the Moulder Center for Drug Discovery Research Member of the Temple Materials Institute Associate Member of the Center for Targeted Therapeutics and Translational Nanomedicine of the University of Pennsylvania Member of Temple Fox Chase Cancer Center Imaging Consortium EDUCATION NRSA/NIH Postdoctoral fellow, University of Pennsylvania Health System, Department of Pharmacology (2006-2007); Mentors: Professors Vladimir Muzykantov and Ian Blair Postdoctoral fellow, University of Pennsylvania, Department of Chemistry (2004-2006); Mentor: Professor Virgil Percec Welch postdoctoral fellow, Texas A&M University, Galveston, TX, and Visiting scientist, University of Texas Medical Branch at Galveston, TX; (2001-2004); Mentors: Professors Alexandru T. Balaban, William A. Seitz, and E. Brad Thompson Ph. D., Chemistry, University “Politehnica” Bucharest, Romania, 2001 Thesis title: “Novel pyrylium and pyridinium salts with biological activity” Adviser: Professor Alexandru T. Balaban F. Rom. Acad.