Journal of Pharmaceutical Research And Opinion 1:3 (2011) 92 – 93 Contents lists available at www.innovativejournal.in JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION Journal homepage: http://www.innovativejournal.in/index.php/jpro RESEARCH EVALUATION OF ANTIFERTILITY POTENTIAL OF CALOTROPIS GIGANTEA LINN. IN FEMALE ALBINO RATS. M. Mishra 1, R. K Gautam2, R. Mathur3* 1School of Zoology and Anthropology, Opp. GDA, Gwalior. Madhya Pradesh, India. 2School of Life sciences, Khandari campus, Agra Univerisity, Agra, Uttar Pradesh. India. 3School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh, India. ARTICLE INFO ABSTRACT Received 22 July 2011 The present study has been undertaken to evaluate antifertility and ovaro-uterotoxic Accepted 28 July 2011 activities of the extracts of Calotropis gigantea Linn. Animals studied were divided Corresponding Author: into various groups control and experimental groups. Crude and ethanolic extracts R.Mathur were prepared and 150 and 300 mg/kg body weight doses were selected.
[email protected] Oestrogenicity/antioestrogenicity was tested by using bilaterally ovariectomized School of Studies in Zoology, immature rats. Biochemical parameters viz. uterine glycogen, total protein, acid and Jiwaji University, Gwalior, alkaline phosphatase were measured and compared with control and vehicle. The Madhya Pradesh, India. findings suggest that the extracts are strong antiestrogenic and antiprogestagenic. Sharp decline was found in uterine glycogen, total proteins and acid phosphatase level whereas the level of alkaline phosphatase was found to increase. Though the KeyWords: Antifertility, extracts are highly toxic at higher doses yet they exhibit potential to be elucidated as Calotropin, Endometrium, female antifertility agents with proper control of toxicity. Hyaluronic acid ©2011, JPRO, All Right Reserved.