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Oral Lichen Planus: a Case Report and Review of Literature
Journal of the American Osteopathic College of Dermatology Volume 10, Number 1 SPONSORS: ',/"!,0!4(/,/'9,!"/2!4/29s-%$)#)3 March 2008 34)%&%,,!"/2!4/2)%3s#/,,!'%.%8 www.aocd.org Journal of the American Osteopathic College of Dermatology 2007-2008 Officers President: Jay Gottlieb, DO President Elect: Donald Tillman, DO Journal of the First Vice President: Marc Epstein, DO Second Vice President: Leslie Kramer, DO Third Vice President: Bradley Glick, DO American Secretary-Treasurer: Jere Mammino, DO (2007-2010) Immediate Past President: Bill Way, DO Trustees: James Towry, DO (2006-2008) Osteopathic Mark Kuriata, DO (2007-2010) Karen Neubauer, DO (2006-2008) College of David Grice, DO (2007-2010) Dermatology Sponsors: Global Pathology Laboratory Stiefel Laboratories Editors +BZ4(PUUMJFC %0 '0$00 Medicis 4UBOMFZ&4LPQJU %0 '"0$% CollaGenex +BNFT2%FM3PTTP %0 '"0$% Editorial Review Board 3POBME.JMMFS %0 JAOCD &VHFOF$POUF %0 Founding Sponsor &WBOHFMPT1PVMPT .% A0$%t&*MMJOPJTt,JSLTWJMMF .0 4UFQIFO1VSDFMM %0 t'"9 %BSSFM3JHFM .% wwwBPDEPSg 3PCFSU4DIXBS[F %0 COPYRIGHT AND PERMISSION: written permission must "OESFX)BOMZ .% be obtained from the Journal of the American Osteopathic College of Dermatology for copying or reprinting text of .JDIBFM4DPUU %0 more than half page, tables or figurFT Permissions are $JOEZ)PGGNBO %0 normally granted contingent upon similar permission from $IBSMFT)VHIFT %0 the author(s), inclusion of acknowledgement of the original source, and a payment of per page, table or figure of #JMM8BZ %0 reproduced matFSJBMPermission fees -
Arsenicosis Presenting with Cutaneous Squamous Cell Carcinoma: a Case Report
CASE REPORT Arsenicosis Presenting with Cutaneous Squamous Cell Carcinoma: A Case Report Marie Len A. Camaclang,1 Eileen Liesl A. Cubillan2 and Claudine Yap-Silva2 1Section of Dermatology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila 2Section of Dermatology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila ABSTRACT A 29-year-old male with eleven-year history of hyperkeratotic papules and speckled pigmentation developed cutaneous squamous cell carcinoma. Arsenicosis was confirmed by elevated hair arsenic level, and histopathologic findings of arsenical keratosis and one lesion showing carcinoma-in-situ. Chronic arsenic exposure has been found to activate inflammatory and carcinogenic pathways leading to development of pre-malignant and malignant lesions. A multi-disciplinary approach involving healthcare specialists and environmentalists is crucial in source control and management of long-term complications. Key Words: arsenic, arsenic poisoning, arsenicosis, skin cancer, squamous cell carcinoma INTRODUCTION Arsenic is a potential human carcinogen of public health concern. Exposure may be via inhalation of arsenic dusts, direct contact with arsenites, or ingestion of contaminated water, the latter being the most common route.1 Chemical contamination of groundwater may come from natural sources such as geochemical processes (e.g. volcanic activities), as well as the result of human activities including mining wastes, landfills, -
Autoinvolutive Photoexacerbated Tinea Corporis Mimicking a Subacute Cutaneous Lupus Erythematosus
Letters to the Editor 141 low-potency steroids had no eŒect. Our patient was treated 4. Jarrat M, Ramsdell W. Infantile acropustulosis. Arch Dermatol with a modern glucocorticoid which has an improved risk– 1979; 115: 834–836. bene t ratio. The antipruritic and anti-in ammatory properties 5. Kahn G, Rywlin AM. Acropustulosis of infancy. Arch Dermatol of the steroid were increased by applying it in combination 1979; 115: 831–833. 6. Newton JA, Salisbury J, Marsden A, McGibbon DH. with a wet-wrap technique, which has already been shown to Acropustulosis of infancy. Br J Dermatol 1986; 115: 735–739. be extremely helpful in cases of acute exacerbations of atopic 7. Mancini AJ, Frieden IJ, Praller AS. Infantile acropustulosis eczema in combination with (3) or even without topical revisited: history of scabies and response to topical corticosteroids. steroids (8). Pediatr Dermatol 1998; 15: 337–341. 8. Abeck D, Brockow K, Mempel M, Fesq H, Ring J. Treatment of acute exacerbated atopic eczema with emollient-antiseptic prepara- tions using ‘‘wet-wrap’’ (‘‘wet-pyjama’’) technique. Hautarzt 1999; REFERENCES 50: 418–421. 1. Vignon-Pennam en M-D, Wallach D. Infantile acropustulosis. Arch Dermatol 1986; 122: 1155–1160. Accepted November 24, 2000. 2. Duvanel T, Harms M. Infantile Akropustulose. Hautarzt 1988; 39: 1–4. Markus Braun-Falco, Silke Stachowitz, Christina Schnopp, Johannes 3. Oranje AP, Wolkerstorfer A, de Waard-van der Spek FB. Treatment Ring and Dietrich Abeck of erythrodermic atopic dermatitis with ‘‘wet-wrap’’ uticasone Klinik und Poliklinik fu¨r Dermatologie und Allergologie am propionate 0,05% cream/emollient 1:1 dressing. -
Eosinophilic Cellulitis (Wells Syndrome): a Case Report
International Journal of Research in Dermatology Baabdullah AM et al. Int J Res Dermatol. 2021 May;7(3):450-453 http://www.ijord.com DOI: https://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20211708 Case Report Eosinophilic cellulitis (wells syndrome): a case report Ahmad Mohammad Baabdullah1, Khalid Ali Al Hawsawi2, Bashayr Saad Alhubayshi3*, Marwa Rashed Gammash4 1Department of Dermatology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia 2 Department of Dermatology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia 3Taibah College of Medicine, Taibah University, Almadinah Almunawwarah, Saudi Arabia 4Collage of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Received: 14 January 2021 Accepted: 08 February 2021 *Correspondence: Dr. Bashayr Saad Alhubayshi, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Eosinophilic Cellulitis is also known as Wells syndrome is uncommon dermatitis, characterized by the infiltration of eosinophils in the dermis. The exact etiology of the disease is unknown. Clinically, it is highly varied but commonly the presentation is pruritic erythematous plaque. We report a case of one and half years old healthy boy who developed itchy bullae on the dorsum of his hand with multiple erythematous papules over his extremities that started immediately after his vaccines. Histopathological examination of the lesion showed infiltrate eosinophils with typical flame figures. The case was successfully treated with corticosteroid course. -
Drug Treatments in Psoriasis
Drug Treatments in Psoriasis Authors: David Gravette, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Morgan Luger, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Jay Moulton, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Wesley T. Lindsey, Pharm.D., Associate Clinical Professor of Pharmacy Practice, Drug Information and Learning Resource Center, Harrison School of Pharmacy, Auburn University Universal Activity #: 0178-0000-13-108-H01-P | 1.5 contact hours (.15 CEUs) Initial Release Date: November 29, 2013 | Expires: April 1, 2016 Alabama Pharmacy Association | 334.271.4222 | www.aparx.org | [email protected] SPRING 2014: CONTINUING EDUCATION |WWW.APARX.Org 1 EducatiONAL OBJECTIVES After the completion of this activity pharmacists will be able to: • Outline how to diagnose psoriasis. • Describe the different types of psoriasis. • Outline nonpharmacologic and pharmacologic treatments for psoriasis. • Describe research on new biologic drugs to be used for the treatment of psoriasis as well as alternative FDA uses for approved drugs. INTRODUCTION depression, and even alcoholism which decreases their quality of Psoriasis is a common immune modulated inflammatory life. It is uncertain why these diseases coincide with one another, disease affecting nearly 17 million people in North America and but it is hypothesized that the chronic inflammatory nature of Europe, which is approximately 2% of the population. The highest psoriasis is the underlying problem. frequencies occur in Caucasians -
Pustular Psoriasis in Children- a Review
Vol. 10, No. 1, 2012 Review Article Pustular Psoriasis in Children- a Review Malathi M 1, Thappa DM 2 1Senior Resident, 2Professor and Head, Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605006, India Abstract Pustular psoriasis is a rare form of psoriasis in the pediatric population with the acute generalized and annular variants being the most common. There are two groups of pustular psoriasis one with a history of psoriasis vulgaris and the other without a history of psoriasis vulgaris which differ in various aspects including the age at onset and triggering factors. Several triggering factors have been implicated in generalized pustular psoriasis, the removal or treatment of which can allow the process to settle, which include upper respiratory tract and urinary tract infections, abrupt cessation of oral steroids and cyclosporine, sunburn, tar therapy, hypocalcemia and vaccination. But, generalized pustular psoriasis may present with potential life threatening complications warranting aggressive approach with various treatment modalities like retinoids, methotrexate, cyclosporine, dapsone and biologics which are frequently being used in children. However, the management issues in the pediatric age group are challenging pertaining to a host of precipitating factors, limited clinical experience with the optimal use of these agents in children, long term safety profile of these agents in the long run in children and the lack of long term follow up studies. Key words: Pustular psoriasis; children; complications; retinoids; methotrexate; cyclosporine; dapsone; biologics Correspondence: Dr. DM Thappa Professor and Head, Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605006, India Email : [email protected] NJDVL - 1 Vol. -
Arsenic-Induced Lesions
33 As75 Arsenic-Induced Lesions Prepared By: José A. Centeno, Ph.D.1 Leonor Martínez, M.D.1 Elena R. Ladich, M.D.1 Norbert P. Page, D.V.M., M.S.1 Florabel G. Mullick, M.D., SES1 Kamal G. Ishak, M.D., Ph.D.1 Baoshan Zheng, Ph.D.5 Herman Gibb, Ph.D.2 Claudia Thompson, Ph.D.3 David Longfellow, Ph.D.4 Sponsored By: 1Armed Forces Institute of Pathology American Registry of Pathology 2U.S. Environmental Protection Agency 3National Institute of Environmental Health Sciences 4National Cancer Institute U.S. Geological Service Contributor: 5Institute of Geochemistry & Academia Sinica, P.R. China April 2000 ISBN: 1-881041-68-9 Armed Forces Institute of Pathology American Registry of Pathology Washington, DC 2000 Available from American Registry of Pathology Bookstore Web site at www.afip.org 4 Preface The public health concern for environmental exposure to arsenic 35 ( As75) has been widely recognized for decades. However, recent human activities have resulted in even greater arsenic exposures and the potential increase for chronic arsenic poisoning on a worldwide basis. This is especially the case in China, Taiwan, Thailand, Mexico, Chile, and India. The sources of arsenic expo- José A. Centeno, Ph.D. sure vary from burning of arsenic-rich coal (China) and mining activities (Malaysia, Japan) to the ingestion of arsenic-contami- nated drinking water (Taiwan, Philippines, Mexico, Chile). The groundwater arsenic contamination in Bangladesh and the West Bengal Delta of India has received the greatest international attention due to the large number of people potentially exposed and the high prevalence of arsenic-induced diseases. -
The Management of Psoriasis in Adults
DORSET MEDICINES ADVISORY GROUP THE MANAGEMENT OF PSORIASIS IN ADULTS Psoriasis is a common, genetically determined, inflammatory and proliferative disorder of the skin, the most characteristic lesions consisting of chronic, sharply demarcated, dull-red, scaly plaques, particularly on the extensor prominences and in the scalp. Self-care advice Many people's psoriasis symptoms start or become worse because of a certain event, known as a trigger. Common triggers include: • an injury to skin such as a cut, scrape, insect bite or sunburn (this is known as the Koebner response) • drinking excessive amounts of alcohol • smoking • stress • hormonal changes, particularly in women (for example during puberty and the menopause) • certain medicines such as lithium, some antimalarial medicines, anti-inflammatory medicines including ibuprofen, ACE inhibitors (used to treat high blood pressure) and beta blockers (used to treat congestive heart failure) • throat infections - in some people, usually children and young adults, a form of psoriasis called guttate psoriasis (which causes smaller pink patches, often without a lot of scaling) develops after a streptococcal throat infection, although most people who have streptococcal throat infections do not develop psoriasis • other immune disorders, such as HIV, which cause psoriasis to flare up or to appear for the first time Advice for patients can be found here Management pathway For people with any type of psoriasis assess: • disease severity • the impact of disease on physical, psychological and social wellbeing • whether they have psoriatic arthritis • the presence of comorbidities. • Consider using the Dermatology quality of life assessment: www.pcds.org.uk/p/quality-of-life Assess the severity and impact of any type of psoriasis: • at first presentation • before referral for specialist advice and at each referral point in the treatment pathway • to evaluate the efficacy of interventions. -
Dermatologic Nuances in Children with Skin of Color
5/21/2019 Dermatologic Nuances in Children with Skin of Color Candrice R. Heath, MD, FAAP, FAAD Director, Pediatric Dermatology LKSOM Temple University @DrCandriceHeath Advisory Board – Pfizer, Regeneron-Sanofi Consultant –Marketing – Unilever, Proctor & Gamble Speaker’s Bureau - Pfizer I do not intend to discuss on-FDA approved or investigational use of products in my presentation. • Recognize common hair, scalp and skin disorders that may present differently in children with skin of color • Select appropriate treatment options based upon common cultural preferences to increase adherence • Establish treatment algorithm for challenging cases 1 5/21/2019 • 2050 : Over half of the United States population will be people of color • 2050 : 1 in 3 US residents will be Hispanic • 2023 : Over half of the children in the US will be people of color • Focuses on ethnic and racial groups who have – similar skin characteristics – similar skin diseases – similar reaction patterns to those skin diseases Taylor SC et al. (2016) Defining Skin of Color. In Taylor & Kelly’s Dermatology for Skin of Color. 2016 Type I always burns, never tans (palest) Type II usually burns, tans minimally Type III sometimes mild burn, tans uniformly Type IV burns minimally, always tans well (moderate brown) Type V very rarely burns, tans very easily (dark brown) Type VI Never burns (deeply pigmented dark brown to darkest brown) 2 5/21/2019 • Black • Asian • Hispanic • Other Not so fast… • Darker skin hues • The term “race” is faulty – Race may not equal biological or genetic inheritance – There is not one gene or characteristic that separates every person of one race from another Taylor SC et al. -
Thymoquinone Induces Apoptosis and DNA Damage in 5-Fluorouracil-Resistant Colorectal Cancer Stem/Progenitor Cells
www.oncotarget.com Oncotarget, 2020, Vol. 11, (No. 31), pp: 2959-2972 Research Paper Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Farah Ballout1, Alissar Monzer1, Maamoun Fatfat1, Hala El Ouweini1, Miran A. Jaffa2, Rana Abdel-Samad3, Nadine Darwiche3, Wassim Abou-Kheir4 and Hala Gali-Muhtasib1,4 1Department of Biology, American University of Beirut, Lebanon 2Department of Epidemiology and Population Health, American University of Beirut, Lebanon 3Department of Biochemistry and Molecular Genetics, American University of Beirut, Lebanon 4Center for Drug Discovery and Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Lebanon Correspondence to: Hala Gali-Muhtasib, email: [email protected] Wassim Abou-Kheir, email: [email protected] Keywords: thymoquinone; colorectal cancer stem cells; 5-Fluorouracil resistance; colonospheres; apoptosis Received: October 08, 2019 Accepted: December 16, 2019 Published: August 04, 2020 Copyright: Ballout et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT The high recurrence rates of colorectal cancer have been associated with a small population of cancer stem cells (CSCs) that are resistant to the standard chemotherapeutic drug, 5-fluorouracil (5FU). Thymoquinone (TQ) has shown promising antitumor properties on numerous cancer systems both in vitro and in vivo; however, its effect on colorectal CSCs is poorly established. Here, we investigated TQ’s potential to target CSCs in a three-dimensional (3D) sphere-formation assay enriched for a population of colorectal cancer stem/progenitor cells. -
Case Report and Review of Wells' Syndrome in Childhood Amy E
Bullous “Cellulitis” With Eosinophilia: Case Report and Review of Wells’ Syndrome in Childhood Amy E. Gilliam, MD*; Anna L. Bruckner, MD‡; Rene´e M. Howard, MD*; Brian P. Lee, MD§; Susan Wu, MD§; and Ilona J. Frieden, MD* ABSTRACT. A 1-year-old girl presented with acute on- but later simplified the name to eosinophilic celluli- set of edematous erythematous plaques associated with tis.2 bullae on her extremities and accompanied by peripheral Wells’ syndrome is seen more commonly among eosinophilia. She was afebrile, and the skin lesions were adults but has been observed among children. Some pruritic but not tender. The patient was treated with hypothesize that this syndrome may represent a hy- intravenously administered antibiotics for presumed cel- persensitivity response to a circulating antigen.2 As- lulitis, without improvement. However, the lesions re- sponded rapidly to systemic steroid therapy. On the basis sociated precipitants include insect bites, medication of lesional morphologic features, peripheral eosino- reactions, recent immunization, myeloproliferative philia, and cutaneous histopathologic features, a diagno- disorders, malignancies, and infections. We describe sis of Wells’ syndrome was made. Wells’ syndrome is a case of a young child with no identifiable triggering extremely rare in childhood, with 27 pediatric cases re- factors, and we review the evidence for evaluation ported in the literature. Because it is seen so infre- and management of these pediatric cases. quently, there are no specific guidelines for evaluation and management of Wells’ syndrome among children. CASE REPORT The diagnosis should be considered for children with A previously healthy, 1-year-old girl presented with acute on- presumed cellulitis and eosinophilia who fail to respond set of edematous erythematous plaques, with associated bullae, on to antibiotics. -
Bullous Eosinophilic Annular Erythema
Volume 27 Number 5| May 2021 Dermatology Online Journal || Photo Vignette 27(5):16 Bullous eosinophilic annular erythema Yun Pei Koh1, Hong Liang Tey1-3 Affiliations: 1National Skin Centre, Singapore, 2Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore Corresponding Author: Koh Yun Pei, National Skin Centre, 1 Mandalay Road, Singapore 308405, Singapore, Tel: 65-2534455, Email: [email protected] areas of central clearing (Figure 1). Some plaques Abstract were studded with tense vesicles containing yellow Eosinophilic annular erythema is an idiopathic acute serous fluid, coalescing to form large bullae over his eosinophilic dermatosis. It is a rare condition, with left flank (Figure 2). Total body surface area involved approximately 30 cases reported in the English was 12%. literature. It features annular, figurate urticarial edematous plaques primarily affecting the trunk and Histological examination showed superficial and proximal limbs. During evaluation of a patient, deep perivascular infiltrate of predominantly secondary causes of eosinophilic inflammation such eosinophils and some lymphocytes (Figure 3). as allergy-related conditions (eczema, drug, urticaria, Epidermal involvement, apoptotic keratinocytes, contact dermatitis), parasitic infestations, and interface dermatitis, blistering, vasculitis, or autoimmune dermatoses will need to be excluded. granulomatous inflammation were all absent. Direct We present an unusual case of a 47-year-old patient who developed this condition. Keywords: eosinophilic dermatoses, urticaria Introduction Idiopathic primary eosinophilic dermatoses are a group of primarily eosinophil-driven skin disease characterized by moderate-to-dense eosinophilic skin infiltration with no significant infiltration of other leukocytes. Our case is consistent with one subtype of these conditions—eosinophilic annular erythema (EAE).