Pustular Psoriasis in Children- a Review
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Autoinvolutive Photoexacerbated Tinea Corporis Mimicking a Subacute Cutaneous Lupus Erythematosus
Letters to the Editor 141 low-potency steroids had no eŒect. Our patient was treated 4. Jarrat M, Ramsdell W. Infantile acropustulosis. Arch Dermatol with a modern glucocorticoid which has an improved risk– 1979; 115: 834–836. bene t ratio. The antipruritic and anti-in ammatory properties 5. Kahn G, Rywlin AM. Acropustulosis of infancy. Arch Dermatol of the steroid were increased by applying it in combination 1979; 115: 831–833. 6. Newton JA, Salisbury J, Marsden A, McGibbon DH. with a wet-wrap technique, which has already been shown to Acropustulosis of infancy. Br J Dermatol 1986; 115: 735–739. be extremely helpful in cases of acute exacerbations of atopic 7. Mancini AJ, Frieden IJ, Praller AS. Infantile acropustulosis eczema in combination with (3) or even without topical revisited: history of scabies and response to topical corticosteroids. steroids (8). Pediatr Dermatol 1998; 15: 337–341. 8. Abeck D, Brockow K, Mempel M, Fesq H, Ring J. Treatment of acute exacerbated atopic eczema with emollient-antiseptic prepara- tions using ‘‘wet-wrap’’ (‘‘wet-pyjama’’) technique. Hautarzt 1999; REFERENCES 50: 418–421. 1. Vignon-Pennam en M-D, Wallach D. Infantile acropustulosis. Arch Dermatol 1986; 122: 1155–1160. Accepted November 24, 2000. 2. Duvanel T, Harms M. Infantile Akropustulose. Hautarzt 1988; 39: 1–4. Markus Braun-Falco, Silke Stachowitz, Christina Schnopp, Johannes 3. Oranje AP, Wolkerstorfer A, de Waard-van der Spek FB. Treatment Ring and Dietrich Abeck of erythrodermic atopic dermatitis with ‘‘wet-wrap’’ uticasone Klinik und Poliklinik fu¨r Dermatologie und Allergologie am propionate 0,05% cream/emollient 1:1 dressing. -
Drug Treatments in Psoriasis
Drug Treatments in Psoriasis Authors: David Gravette, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Morgan Luger, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Jay Moulton, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Wesley T. Lindsey, Pharm.D., Associate Clinical Professor of Pharmacy Practice, Drug Information and Learning Resource Center, Harrison School of Pharmacy, Auburn University Universal Activity #: 0178-0000-13-108-H01-P | 1.5 contact hours (.15 CEUs) Initial Release Date: November 29, 2013 | Expires: April 1, 2016 Alabama Pharmacy Association | 334.271.4222 | www.aparx.org | [email protected] SPRING 2014: CONTINUING EDUCATION |WWW.APARX.Org 1 EducatiONAL OBJECTIVES After the completion of this activity pharmacists will be able to: • Outline how to diagnose psoriasis. • Describe the different types of psoriasis. • Outline nonpharmacologic and pharmacologic treatments for psoriasis. • Describe research on new biologic drugs to be used for the treatment of psoriasis as well as alternative FDA uses for approved drugs. INTRODUCTION depression, and even alcoholism which decreases their quality of Psoriasis is a common immune modulated inflammatory life. It is uncertain why these diseases coincide with one another, disease affecting nearly 17 million people in North America and but it is hypothesized that the chronic inflammatory nature of Europe, which is approximately 2% of the population. The highest psoriasis is the underlying problem. frequencies occur in Caucasians -
The Management of Psoriasis in Adults
DORSET MEDICINES ADVISORY GROUP THE MANAGEMENT OF PSORIASIS IN ADULTS Psoriasis is a common, genetically determined, inflammatory and proliferative disorder of the skin, the most characteristic lesions consisting of chronic, sharply demarcated, dull-red, scaly plaques, particularly on the extensor prominences and in the scalp. Self-care advice Many people's psoriasis symptoms start or become worse because of a certain event, known as a trigger. Common triggers include: • an injury to skin such as a cut, scrape, insect bite or sunburn (this is known as the Koebner response) • drinking excessive amounts of alcohol • smoking • stress • hormonal changes, particularly in women (for example during puberty and the menopause) • certain medicines such as lithium, some antimalarial medicines, anti-inflammatory medicines including ibuprofen, ACE inhibitors (used to treat high blood pressure) and beta blockers (used to treat congestive heart failure) • throat infections - in some people, usually children and young adults, a form of psoriasis called guttate psoriasis (which causes smaller pink patches, often without a lot of scaling) develops after a streptococcal throat infection, although most people who have streptococcal throat infections do not develop psoriasis • other immune disorders, such as HIV, which cause psoriasis to flare up or to appear for the first time Advice for patients can be found here Management pathway For people with any type of psoriasis assess: • disease severity • the impact of disease on physical, psychological and social wellbeing • whether they have psoriatic arthritis • the presence of comorbidities. • Consider using the Dermatology quality of life assessment: www.pcds.org.uk/p/quality-of-life Assess the severity and impact of any type of psoriasis: • at first presentation • before referral for specialist advice and at each referral point in the treatment pathway • to evaluate the efficacy of interventions. -
Dermatologic Nuances in Children with Skin of Color
5/21/2019 Dermatologic Nuances in Children with Skin of Color Candrice R. Heath, MD, FAAP, FAAD Director, Pediatric Dermatology LKSOM Temple University @DrCandriceHeath Advisory Board – Pfizer, Regeneron-Sanofi Consultant –Marketing – Unilever, Proctor & Gamble Speaker’s Bureau - Pfizer I do not intend to discuss on-FDA approved or investigational use of products in my presentation. • Recognize common hair, scalp and skin disorders that may present differently in children with skin of color • Select appropriate treatment options based upon common cultural preferences to increase adherence • Establish treatment algorithm for challenging cases 1 5/21/2019 • 2050 : Over half of the United States population will be people of color • 2050 : 1 in 3 US residents will be Hispanic • 2023 : Over half of the children in the US will be people of color • Focuses on ethnic and racial groups who have – similar skin characteristics – similar skin diseases – similar reaction patterns to those skin diseases Taylor SC et al. (2016) Defining Skin of Color. In Taylor & Kelly’s Dermatology for Skin of Color. 2016 Type I always burns, never tans (palest) Type II usually burns, tans minimally Type III sometimes mild burn, tans uniformly Type IV burns minimally, always tans well (moderate brown) Type V very rarely burns, tans very easily (dark brown) Type VI Never burns (deeply pigmented dark brown to darkest brown) 2 5/21/2019 • Black • Asian • Hispanic • Other Not so fast… • Darker skin hues • The term “race” is faulty – Race may not equal biological or genetic inheritance – There is not one gene or characteristic that separates every person of one race from another Taylor SC et al. -
Immune Response Patterns in Non‐Communicable Inflammatory Skin
DOI: 10.1111/jdv.14673 JEADV REVIEW ARTICLE Immune response patterns in non-communicable inflammatory skin diseases K. Eyerich,1,* S. Eyerich2 1Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany 2ZAUM – Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Munich, Germany *Correspondence: K. Eyerich. E-mail: [email protected] Abstract Non-communicable inflammatory skin diseases (ncISD) such as psoriasis or atopic eczema are a major cause of global disease burden. Due to their impact and complexity, ncISD represent a major challenge of modern medicine. Dermatol- ogy textbooks describe more than 100 different ncISD based on clinical phenotype and histological architecture. In the last decades, this historical description was complemented by increasing molecular knowledge – and this knowledge is now being translated into specific therapeutics. Combining the enormous advances made in lymphocyte immunology and molecular genetics with clinical and histological phenotyping reveals six immune response patterns of the skin – type I immune cells cause the lichenoid pattern characterized by immune-mediated cell death of keratinocytes; type II immune cells underlie the eczematous pattern with impaired epidermal barrier, infection and eosinophils as well as the bullous pattern with loss of epithelial integrity; Th17 cells and ILC3 mediate the psoriatic pattern characterized by acan- thosis, high metabolic activity and neutrophils; dysbalance of regulatory T cells causes either the fibrogenic pattern with rarefication of cells and dermal thickening or the granulomatous pattern defined by formation of granulomas. With more and more specific therapeutic agents approved, classifying ncISD also according to their immune response pattern will become highly relevant. -
A Deep Learning System for Differential Diagnosis of Skin Diseases
A deep learning system for differential diagnosis of skin diseases 1 1 1 1 1 1,2 † Yuan Liu , Ayush Jain , Clara Eng , David H. Way , Kang Lee , Peggy Bui , Kimberly Kanada , ‡ 1 1 1 Guilherme de Oliveira Marinho , Jessica Gallegos , Sara Gabriele , Vishakha Gupta , Nalini 1,3,§ 1 4 1 1 Singh , Vivek Natarajan , Rainer Hofmann-Wellenhof , Greg S. Corrado , Lily H. Peng , Dale 1 1 † 1, 1, 1, R. Webster , Dennis Ai , Susan Huang , Yun Liu * , R. Carter Dunn * *, David Coz * * Affiliations: 1 G oogle Health, Palo Alto, CA, USA 2 U niversity of California, San Francisco, CA, USA 3 M assachusetts Institute of Technology, Cambridge, MA, USA 4 M edical University of Graz, Graz, Austria † W ork done at Google Health via Advanced Clinical. ‡ W ork done at Google Health via Adecco Staffing. § W ork done at Google Health. *Corresponding author: [email protected] **These authors contributed equally to this work. Abstract Skin and subcutaneous conditions affect an estimated 1.9 billion people at any given time and remain the fourth leading cause of non-fatal disease burden worldwide. Access to dermatology care is limited due to a shortage of dermatologists, causing long wait times and leading patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in over- and under-referrals, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). -
(12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr
USOO7359748B1 (12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr. 15, 2008 (54) APPARATUS FOR TOTAL IMMERSION 6,339,216 B1* 1/2002 Wake ..................... 250,214. A PHOTOGRAPHY 6,397,091 B2 * 5/2002 Diab et al. .................. 600,323 6,556,858 B1 * 4/2003 Zeman ............. ... 600,473 (76) Inventor: Rhett Drugge, 50 Glenbrook Rd., Suite 6,597,941 B2. T/2003 Fontenot et al. ............ 600/473 1C, Stamford, NH (US) 06902-2914 7,092,014 B1 8/2006 Li et al. .................. 348.218.1 (*) Notice: Subject to any disclaimer, the term of this k cited. by examiner patent is extended or adjusted under 35 Primary Examiner Daniel Robinson U.S.C. 154(b) by 802 days. (74) Attorney, Agent, or Firm—McCarter & English, LLP (21) Appl. No.: 09/625,712 (57) ABSTRACT (22) Filed: Jul. 26, 2000 Total Immersion Photography (TIP) is disclosed, preferably for the use of screening for various medical and cosmetic (51) Int. Cl. conditions. TIP, in a preferred embodiment, comprises an A6 IB 6/00 (2006.01) enclosed structure that may be sized in accordance with an (52) U.S. Cl. ....................................... 600/476; 600/477 entire person, or individual body parts. Disposed therein are (58) Field of Classification Search ................ 600/476, a plurality of imaging means which may gather a variety of 600/162,407, 477, 478,479, 480; A61 B 6/00 information, e.g., chemical, light, temperature, etc. In a See application file for complete search history. preferred embodiment, a computer and plurality of USB (56) References Cited hubs are used to remotely operate and control digital cam eras. -
A Dissertation on a CLINICAL STUDY of NAIL CHANGES in PAPULOSQUAMOUS DISORDER
A Dissertation on A CLINICAL STUDY OF NAIL CHANGES IN PAPULOSQUAMOUS DISORDER Dissertation Submitted to THE TAMILNADU Dr.M.G.R. MEDICAL UNIVERSITY CHENNAI - 600 032 With partial fulfillment of the regulations for the award of M.D. DEGREE IN DERMATOLOGY , VENEREOLOGY AND LEPROLOGY (BRANCH – XII) COIMBATORE MEDICAL COLLEGE, COIMBATORE MAY 2018 DECLARATION I Dr. A. AMUTHA solemnly declare that the dissertation entitled “A CLINICALSTUDY OF NAIL CHANGES IN PAPULOSQUAMOUS DISORDER ” is a bonafide work done by me at Coimbatore Medical College Hospital during the year JUNE 2016- JUNE 2017 under the guidance & supervision of Dr.M .REVATHY M.D.,D.D., Professor & Head of Department, Department of Dermatology, Coimbatore Medical College & Hospital. The dissertation is submitted to Dr.MGR Medical University toward partial fulfilment of requirement for the award of MD degree branch XII Dermatology, Venereology and Leprology. PLACE: Dr A. AMUTHA DATE : COPYRIGHT DECLARATION BY THE CANDIDATE I hereby declare that The Tamilnadu Dr. M.G.R Medical University, Chennai shall have the rights to preserve, use and disseminate thisdissertation / thesis in print or electronic format for academic / researchpurpose. PLACE: COIMBATORE Dr.A.AMUTHA DATE: CERTIFICATE This is to certify that the dissertation entitled “A CLINICAL STUDY OF NAIL CHANGES IN PAPULOSQUAMOUS DISORDER” is a bonafide original work done by Dr. A. AMUTHA post graduate student in the Department of Dermatology, Venereology and Leprology, Coimbatore Medical College Hospital during the year JUNE 2016- JUNE 2017 under the guidance & supervision of Dr.M.REVATHYM.D (Derm)., Professor & Head of Department, Department of Dermatology, Coimbatore Medical College & Hospital. The dissertation is submitted to Dr.MGR Medical University toward partial fulfilment of requirement for the award of MD degree branch XII Dermatology, Venereology and Leprology. -
Common Skin Diseases
MODULE \ Common Skin Diseases Diploma Program For the Ethiopian Health Center Team Zewdu Bezie, Bishaw Deboch, Dereje Ayele, Desta Workeneh, Muluneh Haile, Gebru Mulugeta, Getachew Belay, Adane Sewhunegn, Ahmed Mohammed Jimma University In collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education 2005 Funded under USAID Cooperative Agreement No. 663-A-00-00-0358-00. Produced in collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education. Important Guidelines for Printing and Photocopying Limited permission is granted free of charge to print or photocopy all pages of this publication for educational, not-for-profit use by health care workers, students or faculty. All copies must retain all author credits and copyright notices included in the original document. Under no circumstances is it permissible to sell or distribute on a commercial basis, or to claim authorship of, copies of material reproduced from this publication. ©2005 by Zewdu Bezie, Bishaw Deboch, Dereje Ayele, Desta Workeneh, Muluneh Haile, Gebru Mulugeta, Getachew Belay, Adane Sewhunegn, Ahmed Mohammed All rights reserved. Except as expressly provided above, no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission of the author or authors. This material is intended for educational use only by practicing health care workers or students and faculty in a health care field. ACKNOWLEDGEMENT The preparation of this module has passed through series of meetings, discussions revisions and group works. -
Off-Label Studies on Apremilast in Dermatology: a Review
Journal of Dermatological Treatment ISSN: 0954-6634 (Print) 1471-1753 (Online) Journal homepage: https://www.tandfonline.com/loi/ijdt20 Off-label studies on apremilast in dermatology: a review Nolan J. Maloney, Jeffrey Zhao, Kyle Tegtmeyer, Ernest Y. Lee & Kyle Cheng To cite this article: Nolan J. Maloney, Jeffrey Zhao, Kyle Tegtmeyer, Ernest Y. Lee & Kyle Cheng (2019): Off-label studies on apremilast in dermatology: a review, Journal of Dermatological Treatment, DOI: 10.1080/09546634.2019.1589641 To link to this article: https://doi.org/10.1080/09546634.2019.1589641 Published online: 02 Apr 2019. Submit your article to this journal View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ijdt20 JOURNAL OF DERMATOLOGICAL TREATMENT https://doi.org/10.1080/09546634.2019.1589641 REVIEW ARTICLE Off-label studies on apremilast in dermatology: a review Nolan J. Maloneya , Jeffrey Zhaob , Kyle Tegtmeyerb , Ernest Y. Leec,d and Kyle Chenga aDivision of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; bNorthwestern University Feinberg School of Medicine, Chicago, IL, USA; cDavid Geffen School of Medicine at UCLA, UCLA-Caltech Medical Scientist Training Program, Los Angeles, CA, USA; dDepartment of Bioengineering, UCLA, Los Angeles, CA, USA ABSTRACT ARTICLE HISTORY Purpose: Apremilast is a phosphodiesterase-4 inhibitor FDA approved for psoriatic arthritis and moderate Received 26 October 2018 to severe plaque psoriasis. In recent years, multiple studies have suggested other potential uses for apre- Accepted 4 February 2019 milast in dermatology. A summary of these various studies will be a valuable aid to dermatologists con- sidering apremilast for an alternative indication. -
Appendix I. Formulary
Appendix I. Formulary This section briefly summarizes the wide vari text. Before prescribing any of these products, ety of products used by dermatologists. It is be sure to check the latest manufacturer's rec designed to provide a single source of inform a ommendations. tion for products mentioned throughout the Table of Contents I. Acne therapy 330 VI. Cosmetics 335-336 II. Antimicrobial agents 331-333 VII. Light-related products 336 III. Antiparasitic agents 333 VIII. Miscellaneous topical 337-339 IV. Antipruritic agents 333-334 IX. Miscellaneous systemic 339-340 V. Corticosteroids 334-335 Category Trade name Form, size, or % Comments I. Acne therapy A. "Classic" products 1. Sulfur Hundreds of well-known prod 2%-5% Nonprescription pastes or lotions, either white or flesh-tinted, con 2. Resorcinol ucts 1%-2% taining combinations of these three ingredients to primary cause 3. Salicylic acid 1%-2% drying and peeling. B. Antibiotics 1. Topical agents All are applied b.i.d.-t.i.d. a. Tetracycline Topicycline Solution Causes green color and glows under black light. b. Meclocycline Meclan Cream The only cream, therefore less drying. c. Erythromycin Staticin, ATS Solution d. Clindamycin Cleocin T Solution Cleocin T avoids the GI problems of systemic clindamycin. 2. Systemic agents a. Tetracycline 250-1000 mglday Must be taken on empty stomach. Use in daily or b.i.d. dosage; stains teeth, so not to be used in children or pregnant females. b. Erythromycin 250-1000 mglday Use similar to tetracycline; avoid estolate for long-term use. c. Minocycline Minocin 50-100 mglday May help in severe nodulocystic acne; can be taken with meals. -
Common Rashes in Neonates FOCUS
The first 3 months Common rashes John Su in neonates Background Neonatal skin is special in many ways, being thinner, less Neonatal skin is structurally unique. Dermatological diseases hairy and less firmly attached than mature skin. Protective in neonates are commonly benign and self limiting, but they flora is absent and the microbiological load encountered is may also herald underlying systemic disease and can be life in continuous flux. Transepidermal water loss is particularly threatening. elevated in babies born prematurely (33–34 weeks gestation), Objective notably during the first 2–3 weeks of life, and this period This article examines neonatal dermatoses according to of additional vulnerability may last up to 2 months in more various clinical presentations. Clinical clues helping to premature babies. 1 Furthermore, neonates have a relatively differentiate serious and benign conditions are outlined, high body surface area. These factors affect fluid, electrolyte together with an approach to the initial management of and thermal regulation, but also predispose to potential common disease presentations. drug and toxin absorption and toxicity. Such toxicity has Discussion been reported for iodine, silver, mercury, isopropyl alcohol, Functionally, neonatal skin is predisposed to greater heat and urea, salicylic acid, boric acid, local anaesthetics, topical fluid loss as well as drug and toxin absorption. Structurally, antibiotics, some scabicides and steroids. 2 its immaturity often results in understated, atypical and ambiguous skin symptoms and signs. Common morphologies Neonatal skin is usually soft and smooth, covered with vernix caseosa, of neonatal skin diseases include pustules; vesicles and bullae; a derivative of sebaceous secretion and decomposing epidermal cells.