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Nephrotic Syndrome

Nephrotic Syndrome is a collection of signs and symptoms characterized by dysfunction in the part of the kidney that filters blood (glomeruli). Nephrotic Syndrome can be diagnosed with a urine test.

Nephrotic Syndrome Although primary Nephrotic Syndrome is a rare disease, Common Symptoms: anyone can get it. In fact, it’s one of the most - Protein in the urine, which can be foamy (called common contributors proteinuria) of Chronic Kidney Disease in children. - Low levels of protein in the blood Males are - Swelling in parts of the body, most noticeably around more likely to the eyes, hands, feet, and abdomen (called edema) have Nephrotic Syndrome - Weight gain due to extra fluid building up in your body than females. - Can cause high blood pressure (called hypertension) Remission and high fat levels in the blood (high cholesterol) means there is currently no protein spilling into the urine. Nephrotic Fast Facts Syndrome is often misdiagnosed Some of the diseases that cause Nephrotic Syndrome as allergies. include Minimal Change Disease, FSGS, and Membranous Each Nephropathy. These diseases are called “idiopathic” Nephrotic because they occur without a known cause. Syndrome patient follows a unique NS In Adults NS In Children journey.

- FSGS causes Nephrotic - Minimal Change Disease Conditions that Syndrome in adults more is the most common cause occur in other frequently than in children of Nephrotic Syndrome in parts of the body and is most prevalent in children, associated with can cause secondary adults 45 years or older. 80% of cases. Nephrotic Syndrome. These conditions include - In the United States, adult - 2-4 out of every 100,000 diabetes, cancer, lupus, incidence of primary children are diagnosed amyloidosis, infection, Nephrotic Syndrome each with primary Nephrotic drug use, allergies, year is 3 out of every Syndrome each year in and vasculitis. 100,000 individuals. North America. TreatingTreating YourYour DiseaseDisease

Short-Term Goals Long-Term Goals

The short-term goal of treatment is to stop The long-term goals of treatment include protein spillage completely (remission) or to preventing relapses of protein in the urine and lower the amount of protein lost in the urine preventing the deterioration of kidney as much as possible. function.

There are currently very few FDA-approved treatment options for Nephrotic Syndrome. The standard first-line treatment for Nephrotic Syndrome is Prednisone, a corticosteroid.

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Switching to a low-fat, low-sodium Finding a nephrologist that you diet will help improve your kidneys’ 2. trust is very important to your 1. function and your Nephrotic Syndrome long-term health. symptoms.

Learn about your disease, treatment NephCure Kidney International can help you connect with other patients and find options, and clinical trials in order to 3. 4. support to manage your disease. better advocate for yourself.

NephCure Kidney International is working every day to leverage support to find better ® treatments and a cure for Nephrotic Syndrome.

Please visit NephCure.org to learn more about Nephrotic Syndrome.