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Vol 380:1813-14 Volume 3 Topics Volume 1 Page 1. ADHD . 9 2 Addiction . 133 3. Anxiety, Stress & Adjustment Disorders . 327 4. Art and Psychiatry . 437 5. Biological Psychiatry & Neuroscience. 461 Volume 2 Page 6. Brain and Pain . 9 7. Child & Adolescent Mental & Behavioral Disorders . 19 8. Conflict Management & Resolution . 195 9. Dementia, Delirium and Related Cognitive Disorders . 201 10. Diagnostic Systems . 281 11. Disasters & Emergencies in Psych. 297 12. Dissociative, Somatization & Factitious Disorders . 307 Topics Page 14. Eating Disorders . 331 15. Ecology, Psychiatry & Mental Health. 399 16. Epidemiology and Public Health. 405 17. Ethics, Law, Human Rights & Mental Health . 499 Volume 3 Page 18. Evolutionary Psychiatry . 9 19. E xercise Psychiatry and Sports . 17 20. Family Research, Intervention & Interdisciplinary Collaboration . 33 21. Forensic Psychiatry . 65 22. Genetic Psychiatry . 117 23. Geriatric Psychiatry . 139 24. History and Psychiatry . 191 25. HIV and Psychiatry . 221 26. Human Development . 243 abstracts - volume 3 Topics Page 27. Human Sexuality . 253 28. Immunology and Psychiatry . 259 29. Impulse – Control Disorders . .275 30. Learning Disorders . 285 31. Literature and Mental Health. 293 32. Mass Media and Mental Health. 299 33. Measurement Instruments in Psychiatric Care . 307 34. Mental Health, Economics & Services Research . 331 35. Military Psychiatry . 365 36. Miscellaneous . 377 Volume 4 Page 37. Mood Disorders . 9 38. Neural Sciences . 177 39. Neuroimaging in Psychiatry . 195 Topics Page 40. Neuropsychiatry and Behavioral Neurology . 247 41. Occupational Psychiatry, Psychiatric Rehabilitation . 307 43. Personality and Psychopathology . 329 44. Personality Disorders & Accentuated Personality . 357 45. Pharmacotherapies . 385 46. Philosophy and Humanities in Psychiatry . 501 Volume 5 Page 47. Prevention and Health Promotion . 9 48. Primary Care and Mental Health . 51 49. Psychiatric Classification . 103 50. Psychiatry Education and Training . 109 51. Psychiatry in Developing Regions . 139 abstracts - volume 3 Topics Page 52. Psychiatry in Private Practice . 171 53. Psychoanalysis in Psychiatry . 175 54. Psychological Consequences of Torture and Persecution . 189 55. Psychological Sciences . 199 56. Psychoneurobiology . 213 57. Psychoneuroendocrinology . 225 58. Psycho-Oncology & Palliative Care . 239 59. Psychophysiology in Psychiatry . 259 60. Psychosomatic Disorders . 273 61. Psychotherapies. 317 62. Public Psychiatry . 389 63. Quality Assurance in Psychiatry . 405 64. Religion, Spirituality and Psychiatry. 423 65. Research Methods in Psychiatry . 449 66. Rural Mental Heath . 473 Topics Volume 6 Page 67. Schizophrenia & Psychotic Disorders . 9 68. Sexual & Gender Identity Disorders . 287 69. Sleep Disorders . 311 70. Social and Cultural Psychiatry . 329 71. Sociotherapies . 381 72. Stigma and Mental Health . 385 73. Suicide and Psychiatric Emergencies. 435 74. Urban Mental Health . 527 75. Women’s Mental Health . 537 abstracts - volume 3 Topic . s 18 Evolutionary Psychiatry 9 abstracts - volume 3 XVI World Congress of Psychiatry. Madrid 2014 VOL. 3 - TOPIC 18: Evolutionary Psychiatry EVOLUTIONARILY-CONSERVED ENDOPHENOTYPES (PROTOPHENOTYPES) RELATED TO SCHIZOPHRENIA D. S. Dwyer, P. Awatramani, R. Seeni, A. Trinh, E. J. Aamodt Louisiana State University Health Sciences Center, Shreveport, LA, USA Objectives: The main goal of this work is to characterize genes and pathways that mediate evolutionarily-conserved endophenotypes (protophenotypes) associated with schizophrenia. We focused on three endophenotypes: (1) prepulse inhibition, (2) asociality, and (3) avolition/anhedonia. Methods: We have initiated studies of several behaviors in the model organism, Caenorhabditis elegans, that we believe correspond to major endophenotypes related to schizophrenia. The counterpart to prepulse inhibition is touch (startle) suppression of pharyngeal pumping. Solitary vs. social feeding in C. elegans models features of social withdrawal. Avolitional states are induced by concomitant inhibition of insulin signaling, exposure to low levels of dimethylsulfoxide and food deprivation. The effects of genetic mutations, neurotransmitters, and drugs on these behaviors were quantified in various behavioral assays. Specifically, we counted pharyngeal pumping after acute startle, measured the aggregation of animals from the social feeding strain, npr-1(ad609) on food, and assessed spontaneous movement of the avolitional strain, daf-2(e1391), in the presence or absence of drug (e.g., olanzapine). Results: Touch suppression of pharyngeal pumping was primarily mediated by dopaminergic, glutamategic and glycinergic systems in C. elegans. This shows a striking correspondence to regulation of prepulse inhibition in mammals. Social feeding was regulated by antipsychotic drugs, and detailed analysis revealed a role for dopamine, serotonin and calmodulin in this response. Avolition was mediated by excessive serotonin signaling and was partially reversed by olanzapine and clozapine (but not sulpiride), and completely reversed by the 5-HT2 antagonist ritanserin. A partial response to benzodiazepines was observed. Conclusions: C. elegans exhibits behavioral responses that correspond to evolutionarily- conserved endophenotypes associated with schizophrenia. By characterizing these responses, we may gain insights into the basic mechanisms and signaling pathways that mediate prepulse inhibition, social withdrawal, and avolition. www.wpamadrid2014.com ABSTRACTS BOOK 10 XVI DESAFÍOSWorld Congress of Psychiatry.DE LA Madrid PSIQUIATRÍA 2014 ACTUAL VOL. 3 - TOPIC 18: Evolutionary Psychiatry Alfonso Chinchilla Casta Guadarrama. Guadarrama. Madrid. Spain Los principales desafíos de la psiquiatría actual, entre los más importantes, tenemos los siguientes: - El concepto de enfermedad mental. Fronteras con la normalidad. Excesiva psiquiatrización de la vida cotidiana. ¿Salud o funcionalidad? Valor de lo cultural en lo patoplástico y patogénico. - Disquisiciones sobre el cuerpo doctrinal. El modelo biopsicosocial diagnóstico y terapéutico. Controversias sobre clasificaciones. El objeto fundamental es el enfermo, el legado de los maestros , el conocimiento psicopatológico, tan perdido…las aportaciones de otras ciencias foráneas médicas y de otra naturaleza. La excesiva colonización de la psiquiatría americana con sus numerológicos DSM. La ingerencia de la industria y de otros especialistas. El saber si nos vale hoy en dia los conceptos de captación y comprensión de los síntomas por el entender-comprender por motivos y explicar por causas. Las formas de enfermar psiquiátrico: proceso, fase, desarrollo, reacción psicológica y biológica. ¿Los “hallazgos” biológicos de las Neurociencias, Genoma, etc , nos están ayudando de verdad o son más fiables que la vieja psicopatología fenomenológica? - La importancia de la industria y el poder de la FDA o la Agencia Europea del medicamento (casi todos los fármacos valen para todo…), la multitudinaria y heterodoxa variedades de psicoterapias. - Los programas de formación de pregrado y postgrado. ¿Quién los hace? La politicopsiquiatría y el afán de poder más que de enseñar… - De la predisposición genética a los “gatillos psicosociales y personales. - Las “comorbilidades” - Los estudios de modelos etiopatogénicos y de ensayos clínicos y de las publicaciones de “impacto”… - Los “estigmas de la patología mental”. Los “olvidados enfermos crónicos” - Los conceptos de efectividad, eficacia, eficiencia., dimensional, categorial - Derechos de los pacientes y de los profesionales. Estudios transculturales y transhistóricos. - El colonialismo creciente de los DSM - El poder de la PsiquiatrÍa Oficial y su reparto - El uso y abuso de las escalas. Temas todos ellos de auténtico debate y nada resueltos. ¿Estamos mejor ahora que hace 4 ó 5 décadas? Se discuten las variables citadas. www.wpamadrid2014.com ABSTRACTS BOOK 11 SIMPLEXVI World Congress CEPHALO of Psychiatry. Madrid-CAUDAL 2014 PATTERNS EMBEDDEDVOL. 3 - TOPIC IN 18: COMPLEX Evolutionary Psychiatry INTERPERSONAL BEHAVIOR – A NOVEL MODEL FOR BEHAVIOR VK Manduva St Johns Hospital, Kattappana, Kerala, India A novel model is presented to explain human social behavior. In recent years, a cephalo- caudal directionality to behavior has been reported in a few mammals including rodents, cattle and cats. This model shows how complex human behavior also follows this rule of cephalo-caudal directionality. The positions of the lower motor neurons mediating the specific acts in the cephalo-caudal neural axis are considered to be an important determinant of the act. The model posits that movements that constitute behavior consist of a primary ereismatic layer, consisting of three orienting modules – eyes, head and body and a secondary teleokinetic layer consisting of six transmitting channels – the eyes, facial expression, speech, upper limbs, lower limbs and the external genitalia. The model proposes that, with increase in intensity, communications occur in a particular sequence – non-contact communications, followed by extremity-contact communications and finally axial- contact communications. The progression of communication occurs in the following manner: Channel 1 → Channel 1+2 → Channel 1+2+3 → Channel 1+2+3+4 → Channel 1+2+3+4+5 → Channel 1+2+3+4+5+6. Thus, conciliatory communication consists of eye contact, smiling, talking, friendly gestures, friendly approach followed by holding hands/ rubbing legs and followed by kissing and sexual intercourse. Similarly, agonistic communication
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