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C O M M U N I C A T I O N S The author who intended to present the work is indicated by an asterisk (*) on the abstract

312P CUTLER, M.G. & DIXON, 318P HUNTER, A.J.*, MURRAY, A.K. Effects of T.K., OSBORNE, J.M., ipsapirone on behaviour CROSS, A.J. & GREEN, of mice during social A.R. The effects of encounters. chronic administration of oxotremorine and 313P FONE, K.C.F.*, JOHNSON, tetrahydroaminoacridine J.V., BENNETT, G.W. & on cholinergic function MARSDEN, C.A. in the rat. and proctolin alter the 319P BRISTOW, L.J. & behavioural response to BENNETT, G.W. A role intrathecal 5-methoxy- for histamine H3 N,N-dimethyltryptamine receptors in histamine- in rats. induced hypoactivity in the rat. 314P PIPER, D.*, UPTON, N., THOMAS, D. & NICHOLASS, 320P GLOVER, V., CLOW, A.*, J. The effects of the OXENKRUG, G.F. & 5-HT3 receptor SANDLER, M. Stress can antagonists BRL 43694 reduce the effect of an and GR 38032F in animal irreversible MAO behavioural models of inhibitor in vivo. anxiety. 321P NEWBERRY, N.R.* & 315P KENNETT, G.A. & CURZON, GILBERT, M.J. Receptor G. Evidence that mCPP mediated hyper- and TFMPP-induced polarisations of the hypophagia is mediated rat superior cervical by selective activation ganglion in vitro are of 5-HTlc receptors sensitive to pertussis toxin. 316P CLARK, M.L.*, DOURISH, C.T., FLETCHER, A. & 322P WONG, E.H.F., CASTRO, IVERSEN, S.D. Blockade S., McKERNAN, R.M. & of postsynaptic 5-HT1 POAT, J.A. Solubil- receptors elicits ization of the N- feeding in satiated methyl-D-aspartate rats. receptor from rat brain. 317P HEAL, D.J., PROW, M.R.* & BUCKETT, W.R. 323P CHAMBERS, J.K.*, FELER, Measurement of brain C., EMSON, P.C. & MHPG levels suggests IVERSEN, L.L. that induces Tachykinin receptor hypoactivity and subtypes in the rat mydriasis via forebrain. presynaptic a2-adrenoceptors. 324P HEREPATH, M.L. & 331P JACOBS, M.*, DUNN, R.C. BROADLEY, K.J. & BRUC DRER, K.R. Differences in Low-density desensitization of lipoproteins but not cardiac a1 and 02- high-density adrenoceptors of kitten lipoproteins inhibit atria in vitro. EDRF & nitric oxide mediated relaxation of 325P ELFELLAH, M.S. & REID, rabbit aorta. J.L. Regulation of and relationship between 332P POLL, C.*, GRIX, S. & 0-adrenoceptors, Na-K- COLEMAN, R.A. Do ATPase and plasma excitatory neuronal potassium. prostanoid receptors exist in the guinea-pig 326P GAW, A.J.*, HUMPHREY, ileum? P.P.A. & WADSWORTH, R. M. 5-HT receptors and 333P SAEED, S.A. New aspects contractile responses of arachidonic acid to nerve stimulation in metabolism in human sheep middle cerebral placenta. arteries. 334P SHELDRICK, R.L.G.*, 327P BOM, A.H.*, SAXENA, COLEMAN, R.A. & LUMLEY, P.R. & VERDOUW, P.D. P. Iloprost - a potent Further EP1- and IP-receptor characterization of the . 5-HTi-like receptors in the carotid circulation 335P WARNER, T.D.*, de of the pig. NUCCI, G. & VANE, J.R. Comparison of the 328P ABRAHAMSEN, J.* & survivial of EDRF and NEDERGAARD, 0 .A. nitric oxide (NO) Modulation of within the isolated stimulation-evoked perfused mesentery of [ H]-noradrelanine the rat. release from rabbit isolated ear artery. 336P FEATHERSTONE, R.L.*, ROBINSON, C., HOLGATE, 329P COKER, S.J.* & CHESS- S.T. & CHURCH, M.K. WILT AMS, R. Effects Observations on of hypothyroidism on thromboxane receptor- ischaemia and mediated contraction of reperfusion induced guinea-pig and human arrhythmias and adreno- airways by other ceptor responses in prostanoids. rats. 337P KOZAK, W., MILTON, A.S* 330P SAEED, S.A.*, NASREEN, & ROTONDO, D. R. & SURIA, A. Pyrogenic immuno- Synergistic actions of modulators increase the 5-HT and arachidonic accumulation of iositol acid in platelet phosphates in aggregation: effect of monocytes. 5-HT blockers. 338P GILLESPIE, J.S. & 344P JORDAN, V.C*, LANGAN, SHENG, H.* The S. & ROBINSON, S.P. relationship between Metabolism of tamoxifen the EDRF, the smooth in rats and mice: a muscle inhibitory comparison with factor from the BRP and patients undergoing nitric oxide. breast cancer therapy. 339P MERRITT, J.E.*, JACOB, 345P SETT-, P.* & BERRY, R. & HALLAM, T.J. L.A. The effect of Divalent cation influx c-AMP on steroid in human neutrophils is metabolism in isolated, stimulated by f-met- permeabilised rat leu-phe, PAF and hepatocytes. leukotriene B4. 346P WILSON, W.S. Timolol 340P HALLAM, T.J.*, JACOB, reduces intraocular R. & MERRITT, J.Z. pressure in the Influx of divalent isolated, arterially cations into the perfused bovine eye. cytoplasm of human endothelial cells can 347P PALIJ, P.*, BULL, D.R., be independent of SHEEHAN, N.J., receptor stimulation. HUMPHREY, P.P.A., MILLAR, J., STAMFORD, 341P PETTIPHER, E.R.*, J.A. & KRUK, Z.L. A HENDERSON, B. , EDWARDS, new technique for J.C.W. & HIGGS, G.A. quantitative measure- Indomethacin enhances ment of stimulated proteoglycan loss from endogenous articular cartilage in release in brain slices antigen-induced using voltammetry. arthritis. 348P STAMFORD, J.A.*, KRUK, 342P LANCASTER, D.L., Z.L. & MILLAR, J. LENNARD, N.S.*, TUCKER, Effects of uptake G.T., ADIO, R.A., TAI, inhibitors on K.K., BROADHEAD, G.D. stimulated dopamine and WOODS, H.F. In- release and uptake in hibition of metoprolol the nucleus accumbens metabolism by studied by fast cyclic chloroquine and other voltaumetry. antimalarials. 349P JONES, G.H.*, 343P PENNINGTON, J.*, SCOTT, HERNANDEZ, T.D., A.K., REID, I.W. & ROBBINS, T.W. & HAWKSWORTH, G.M. Sub- MARSDEN, C.A. Enhanced strate dependence of striatal response to D- - as revealed induced changes on rat by intracerebral hepatic UDP-glucurono- dialysis following syltransferase. social isolation in rats. 350P WINCH, G.J.B.* & 357P NIXON, G.F., BARR, BALFOUR, D.J.K. S.M.*, HAMILTON, C.A. & Evidence that WADSWORTH, R.M. Is does not evoke the intracellular calcium release of vesicular elevated in dispersed dopamine from striatal arterial smooth muslce slices. cells from hypertensive rabbits? 351P HERDON, H. Regulation of endogenous dopamine 358P RAMAGE, A.G.* & BALL, release from rat S.G. Do angiotensin striatal slices by D-2 converting enzyme (ACE) autoreceptors: effects inhibitors fail to of forskolin and N- cause reflex ethylmaleimide. tachycardia in the cat? 352P SAGGU, H., COOKSEY, J., 359P GARDINER, S.M.*, DEXTER, D.*, JENNER, P. COMPTON, A.M. & & MARSDEN, C.D. A BENNETT, T. Rat selective increase in calcitonin gene-related mitochondrial super- peptide (CGRP) causes oxide dismutase in carotid vasodilation in Parkinsonian substantia conscious, unrestrained nigra. rats. 353P KWAN, Y.W.*, WADSWORTH, 360P HARLAND, D.*, GARDINER, R.M. & KANE, K.A. S.M. AND BENNETT, T. Hypoxia and Brattleboro rats have endothelium-mediated normal cardiac changes in the pharmac- baroreflex ological responsiveness sensitivities that are of sheep circumflex unaffected by centrally coronary arteries. administered vasopressin. 354P ARMAH, B.I.* & RAVENS, U. Inhibition of the 361P DISSANAYAKE, V.U.K.*, inotropic effects of HUNTER, J.C., HILL, DPI 201-106 by its R.G. & HUGHES, J. methyl-indole Characterisation of derivative (BDF 8784) K-opioid receptors in at the sodium-channels. the guinea-pig longitudinal muscle- 355P BUCKINGHAM, R.E.* & myenteric plexus PARROTT, L.S. preparation. Cromakalim (BRL 34915) inhibits noradrenaline- 362P HOLLINGSWORTH, M.*, evoked vasomotion in EDWARDS, D. & MILLER, SHR isolated mesenteric M. Effects of vascular bed. in rat uterus and involvement 356P WATERS, C.M.*, DOWNING, of 5-HT receptors. O.A. & WILSON, K.A. Effect of hypoxia upon noradrenaline induced calcium accumulation in rat arteries. 363P NAHORSKI, S.R.*, COOKE, 367P BAKHLE, Y.S.*, MANN, R. A.M., POTTER, B.V.L., & BELL, C. Are there STRUPISH, J. & dopaminergic nerves in WILLCOCKS, A.L. Eval- guinea-pig lung? uation of myo-inositol (1,4,5)trisphosphoro- 368P NAKAMURA, M.* & SMITH, thioate, a novel T.W. Substance P and phosphatase-resistant peripheral inflammatory analogue of myo- hyperalgesia. inositol (1,4,5)tris- phosphate. 369P LEY, S.J., LIVINGSTON, A. & WATERMAN, A.E.* 364P STUBBS, D.*, SMITH, Changes in plasma J.W., THOMPSON, M., cortisol, WILSON, K.A. & DOWNING, catecholamines and pain O.A. Stimulation of thresholds in sheep al- but not of a2- with a chronically adrenoceptors causes painful clinical hydrolysis of phospho- condition. inositides in the femoral vein of the 370P PURCELL, W.M.*, rat. HANAHOE,T.H.P. & COH1EN, D.L. Effect of 365P AOKI, S., BOUBEKEUR, on the K., KRISTERSSON, A., secretion and uptake of MORLEY, J. & SANJAR, histamine and 5- S.* Is allergic airway hydroxytryptamine from hyperreactivity of the rat peritoneal mast guinea-pig dependent on cells. eosinophil accumulation in the lung? 371P DOUGLAS, G.J.*, WILLIAMS, K.I. & 366P HALL, I.P.* & HILL, FLOWER, R.J. What is S.J. Noradrenaline and Gaddum's "substance R"? inhibit histamine-induced inositol phospholipid hydrolysis in bovine tracheal smooth muscle. P O S T E R C O M M U N I C A T I O N S

372P KINGSTON, J., SHARP, T. 378P LUSCOMBE, G.P., SLATER, & GRAHAME-SNITH, D.G. N.A., WYNNE, R.D., Repeated ECS enhances LYONS, N.B. & BUCKETTI dopamine D-1 but not W.R. Iohibition of in D-2 agonist-induced vitro [ H]-monoamine behavioural responses uptake by plasma taken in rats. from volunteers dosed with the putative anti- 373P VALE, A. L. & BALFOUR, depressant sibutramine D.J.K. Studies on the HC1. role of brain dopamine systems in the psycho- 379P HEAL, D.J., JONES, S.A. stimulant response to & BUCKETT, W.R. nicotine. Administration of sibutramine HC1 and 374P GRAHAM, C.A. & BALFOUR, other D.J.K. The influence including ECS decreases of environmental cortical 01- but not stimuli on the psycho- pharmacological 02-adrenoceptors. response to . 380P O'NEILL, H.C., LANE, A.C., MOTTRAM, D.R. & 375P TRAYNOR, J.R., HILL, D AREN, J.C. R.G., HUGHES, J., [ H]UK14,304 binding to HUNTER, J.C. & rat brain membranes in RODRIGUEZ, R.E. Delta physiological salt opioid-binding sites in solution. the spinal cords of various rodents. 381P VIGE, X. & BRILEY, M. Loss of scopolamine- 376P BARTRUP, J.T. & STONE, induced up-regulation T.W. Adenosine of muscarinic receptors inhibition of rat by Meynert lesions in hippocampal population the rat. potentials is magnesium dependent. 382P LAMBERT, Y. & GOWER, A.J. Antagonism of 377P DEWHURST, D.G. & scopolamine-induced FAIRCLOUGH, A. impairment of swimming Regional brain maze learning in mice. concentrations of putative amino acid 383P JONES, J.A., HUNTER, neurotransmitters A.J., HUTSON, P.H. & during catechol-induced CROSS, A.J. The seizures. effects of 4- aminopyridine on acetylcholine release in vivo and in vitro. 384P FLETCHER, A., FORSTER, 390P COSTALL, B., NAYWOR, E.A., BILL, D.J. & R.J. & TATTERSALL, F.D. BILLINGSLEY, A.J. The antiemetic actions WY 27587: a novel and of 5-HT receptor highly selective antagonists are inhibitor of 5-HT enhanced by uptake in vitro and . in vivo. 391P BARNES, N.M., COSTALL, 385P WHITTINGTON, M.A. & BI & NAYLOR, R.J. LITTLE, H.J. [ H]- Nitrendipine prevents identifies 5-HT3 the ethanol withdrawal binding sites in rat syndrome when entorhinal cortex. administered chronically with 392P CRESPI, F., SLEIGHT, ethanol, prior to A.J., MARTIN, K.F., withdrawal. MARSDEN, C.A. Further evidence that nafion 386P DASHWOOD, M.R., GILBEY, coated carbon fibre M.P., JORDAN, D. & electrodes measure RAMAGE, A.G. extracellular 5-HT Autoradiographic in vivo. localisation of 5-NTA binding sites in the 393P HALES, T.G., LAMBERT, brainstem of the cat. J.J. & PETERS, J.A. 5- HT-induced currents in 387P HUTSON, P.H., SARNA, NCB-20 neuroblastoma G.S.., O'CONNELL, M.T. & hybrid cells and their CURZON, G. Decrease of blockade by a 5-HT hippocampal 5-HT receptor antagonist. release following infusion of 8-OH-DPAT 394P MOORE, J., NAHORSKI, into the dorsal raphe. S.R. & STRUPISH, J. Characterisation of 388P HEATON, J.C.P., dopamine D2 receptors NJUNG'E, K. & HANDLEY, regulating S.L. Behavioural hydroxylase in striatal profile of 1-(2,5- slices. dimethoxy-4- iodophenyl) -2- 395P BAIRD, J.G. & NAHORSKI, aminopropane (DOI), a S.R. A selective role selective 5-HT2 of m scarinic receptors agonist. in K -evoked inositol tetrakisphosphate 389P CRITCHLEY, M.A.E., accumulation in NJUNG'E, K. & HANDLEY, cerebral cortex. S.L. Prevention of 8- OH-DPAT anxiogenic 396P JACKSON, H.C. & effect by ipsapirone KITCHEN, I. Bombesin: and by 5-HT antagonist effects on behaviour 0-adrenoceptor and food intake in antagonists. neonatal rats. 397P BALDWIN, H.A., 404P ARMSTRONG, R.A. & KILPATRICK, G.J., JONES, R.L. JONES, B.J. & FILE, Potentiation by AH6809 S.E1iBrain uptake of of iloprost-induced 2-[ 4C]-deoxyglucose rises in platelet after chronic treatment cyclic AMP levels. with . 405P TIPPINS, J.R., Di 398P LALIES, M. MIDDLEMISS, MARZO, V. & MORRIS, D.N., & RANSOM, R. H.R. Bradykinin- MK-801 is a potent stimulated release of antagonist of NMDA- peptidoleukotrienes stimulated noradren- from rat lung and its aline release from rat inhibition by hippocampal slices. vasoactive intestinal peptide. 399P BARNES, J.M., COSTALL, B. & NAYLOR, R.J. The 406P LUGNIER, C. & SCHINI, neurotoxicity of MPTP V. Characterization of and MPP+ in marmoset cyclic nucleotide phos- cell cultures. phodiesterases in cultured bovine aortic 400P BARNES, J.M., COSTALL, endothelial cells. B. & NAYLOR, R.J. Antagonism by mazindol 407P MELARANGE, R. & of MPTP induced neuro- GITLTT, J.L. The toxicity in rat cell relationship between cultures. endogenous glucocorti- coids and eicosanoid 401P FONE, K.C.F., JOHNSON, formation in J.V., BENNETT, G.W. & alterations to gastric MARSDEN, C.A. Distrib- mucosal integrity. ution of calcitonin gene-related peptide in 408P HILL, J.M. & SPRAGGS, rat and rabbit spinal C.F. Prostaglandin E2 cords. and PGD2 have opposing actions on short 402P HART, S.L., FRIEND, circuit current in rat S.C., GIBSON, A. & isolated colonic COWAN, D.A. The effect mucosa. of an anabolic steroid and chronic exercise on 409P COLLINS, P.D., nociception and plasma WILLIAMS, F.M., corticosterone levels TANNIERE, M. & in rats. WILLIAMS, T.J. Investigation of the 403P LAWRENCE, R.A. & JONES, role of neutrophils and R.L. Prostacyclin PAF in oedema formation analogues contract induced by acute guinea-pig ileum ischaemia of the rabbit longitudinal smooth myocardium. muscle by more than one mechanism. 410P BRUCKDORFER, K.R., 417P SMITH, D.L., NGUYEN, DUNN, R.C. & JACOBS, M. N., FULKS, J. & WILLIS, Endothelium-dependent A.L. The prostacylcin relaxation and low- mimetic RS93427 density lipoproteins: selective inhibition of the importance of platelet mitogen receptor-mediated release from human endocytosis and platelets. oxidation? 418P LATEGAN, T.W., CAUVIN, 411P THOMAS, K., BOOT, J.R., C., WALLNOFER, A. & WOODHOUSE, S. & BAKER, RUEGG, U.T. SMS 201- S.R. The pharmacology 995 may activate the K+ of N-methyl LTCL, a channels of vascular possible LTC4 mimetic. smooth muscle. 412P ROBINSON, C., HARDY, 419P KINGSBURY, M.P. DRAPER, C.C. & HOLGATE, S.T. A.J., REDFERN, P.H, & The metabolism of TODD, M.H. Chronic prostaglandin after effects of in inhalation andDiInfusion spontaneously hyper- in normal men. tensive rats. 413P BEDWELL, S., SHELL, 420P KINGSBURY, M.P., D.J., HOLGATE, S.T. & DRAPER, A.J., REDFERN, ROBINSON, C. P.H. & TODD, M.H. Observations of the Chronic effects of metabolism of atenolol in Wistar prostaglandin D and 9a rats. ll-prostaglandin F2 in human lung. 421P HUSSAINI, I., BHARDWAJ, R. & MOORE, P.K. 414P LINDSAY, C.K., MILTON, Effect of A.S. & ROTONDO, D. fibrinopeptides A and B Thermoregulatory on human and rat responses of endotoxin- platelet aggregation. resistant mice to Poly I:C and endotoxin. 422P TIPPINS, J.R., CLARKE, J., LARKIN, S., YACOUB, 415P BAJKA, E., CRUZ, E. & M. & MASERI, A. WILLIS, A.L. Effects Investigation of the of intravenous and oral action of neuropeptide administration of the Y in the isolated human prostacyclin-mimetic coronary artery. RS93427 in baboons. 423P COLLIS, M.G., CULVER, 416P WOOD, B.E., GRIFFITHS, J.C. & HOLMES, S. R.J., LI, S.W., Comparison of affinity BLACKIAM, A. & of 8-substituted ENTWISTLE, N. Effect xanthines for adenosine of phenidone, receptors in atria from indomethacin and rats and guinea-pigs. dexamethasone on zymosan induced peritoneal inflammation in the rat. 424P STUBBS, D., SMITH, 431P YATES, D.B. Effects of J.W., DOWNING, O.A. & flosequinan, a novel WILSON, K.A. Sources arteriovenous dilating of calcium for agent. contraction of rat femoral vein to al- and 432P CHESS-WILLIAMS, R. & a -adrenoceptor WINN, N.J. Effect of stimulation. chronic treatment with atenolol on depressor 425P MARRIOTT, J.F. & responses to MARSHALL, J.M. The the the anaesthetized influence of hypoxia on rat. acetylcholine-induced relaxation in a range 433P BERTIE, K., DAVIS, of rabbit arteries. J.A., ROACH, A.G., ROWLAND, P. & SMITH 426P BILSKI, A.J., HATTON, C.F.C. SK&F 104078 R., MOORS, J. NUTTALL, does not selectively A. & SHAW, G. The antagonise a -adreno- chronotropic properties ceptors in tie rat. of epanolol in the anaesthetised dog. 434P McAULEY, M.A., MACRAE, I.M. & REID, J.L. 427P GILANI, ANWAR-ul- Central cardiovascular HASSAN. Interaction of effects of neuropeptide himbacine with acetyl- Y and clonidine in the choline at muscarinic rat. receptors of rabbit aorta. 435P WILSON, A.N.A. & BROADLEY, K. J. 428P RANDALL, M.D. & HILEY, responses C.R. Detergent on the guinea-pig artia abolishes carbachol and the effect of vasodilation and endogenous adenosine. changes pressure/flow relations in situ in 436P URQUHART, R.A. & rat superior mesenteric BROADLEY, K.J. The arterial bed. effects of adenosine and NkCA upon noradren- 429P MACLEAN, M.R. & HILEY, aline and potassium C.R. Effects of contracted rabbit enalapril on changes in aorta. cardiac output and its distribution in pithed 437P MORRISON, K.J. & rats with hypoxia and POLLOCK, D. Effects of hypercapnia. vasodilators on tone, cyclic guanosine mono- 430P ALLCOCK, A.A., phosphate levels and FRODSHAK, G. & SIM, phosphatidylinositol M.F. Effects of hydrolysis in rat flosequinan, a novel aortic rings. arteriovenous dilating agent, on cGMP levels in rat isolated aortic strips. 438P BOYLE, S.J. & POLLOCK, 445P DUTHIE, S.J. & GRANT, D. Involvement of N.H. Toxicity of guanylate cyclase in menadione and overflow of mitozantrone in human radioactivity in rat HEP G2 hepatoma cells. atria incubated in (lf]-noradrenaline and 446P ETLLOTT, P.N.C. & [ C]-choline. ROSTRON, C. The anit- inflammatory activity 439P HICKS, P.E., BARRAS, and distribution of M., MINARD, M.A. & indomethacin following ARMSTRONG, J.M. oral and topical Influence of a- administration. adrenoceptors reserve and [K ] on the inhib- 447P McQUEEN, D.S. & itory effects of RITCHIE, I.M. Contri- croukalim and nitrendi- bution of arterial pine in dog saphenous chemoreceptors to vein. salicylate-induced hyperventilation in 440P URQUART, C.J., WILSON, anaesthetized rats. K.A., DOWNING, O.A. & LORD, J.A.H. Effect of 448P WILSON, S.E., HAWKES, inhibitors of ion J.E., BRADSHAW, D. & transport on 5-lT WESTMACOTT, D. The induced increases in effect of short circuit current sulphasalazine and its in rat isolated metabolites on collagen jejunum. arthritis in the mouse. 441P ATTERWILL, C.K. & 449P BALL, S.E., FORRESTER, COLLINS, P. L., WOLF, C.R. & BACK, Investigation of D.J. Characterization aluminium neurotoxicity of the form(s) of using rat brain cytochrome P-450 reaggregate cultures. involved in oestrogen 2-hydroxylation. 442P AHMAD, B. & NICHOLLS, P.J. Interaction of 450P GUMBLETON, M., aminoglutethimide and NICHOLLS, P.J. & SKF 525-A in the souse. TAYLOR, G. The influence of some 443P TINGLE, M.D. & PARK, laboratory anaesthetics B.K. The irreversible on renal and binding of drugs to hepatosplanchnic blood protein in the presence flow in the rat: of chlorine. a microsphere study. 444P PRITCHARD, M.P. & 451P SHAW, M.A. & NICHOLLS, HAWKSWORTH, G.M. P.J. Aminoglutethimide toxicity and thymus weight in in rat hepatocyte the rat. suspensions. 452P COLEMAN, C.S. & 459P BUTLER, J.M. & BACON, WALLACE, H.M. A. Dopamine suppresses Resistance of human the non-cholinergic colorectal cancer cells contraction of to the antimetabolite electrically stimulated methylglyoxal bovine iris sphincter bis(guanylhydrazone). muscle. 453P MCLEAN, W.G. 460P HILL, H., GERAGHTY, I., Inhibition of fast SCHACHTER, M., HUGHES, axonal transport by A. & SEVER, P. 5-HT nerve compression in induced relaxation in the galactose-fed isolated human rabbit is prevented by bronchus. ICI 128436 (Statil). 461P McALPINE, L.G., 454P LINDSAY, R.M. & BATY, McGRATH, J.C., THOMSON, J.D. The effect of N.C. & WILSON, E.P. streptozotocin-induced Physiologically diabetes on the in antagonistic H1 and H2 vitro blood N- receptor subtypes in acetyltransferase rabbit secondary activity of the adult bronchi smooth muscle. male Sprague-Dawley rat. 462P McALPINE, L.G. McGRATH, J.C., THOMSON, N.C. & 455P LINDSAY, R.M. & BATY, WILSON, E.P. Calcium J.D. The effect of dependency of the streptozotocin-induced histamine-induced diabetes on the in vivo contraction in rabbit acetylation capacity of secondary bronchi the adult male Sprague- smooth muscle. Dawley rat. 463P FRASER, S., KENNY, 456P CHANDER, C., CRAIG, D., B.A., KILPATRICK, A.T. NAYLOR, I.L. & TURNER, & SPEDDING, M. Is R.L. Isolated strips fluspiriline a of human endocervical potential ligand for mucosa - a tissue for the site of action of investigating myofibro- class III calcium- blast drug sensitivity. antagonists? 457P JOHNS, E.J. & 464P CLARKE, B., DOYLE, RUTKOWSKI, B. The C.A., PATMORE, L. & actions of atriopeptin SPEDDING, M. III in models of Differential effects of chronic renal failure. calcium-antagonists on insulin secretion. 458P JACKSON, D.M., NORRIS, A.A. & SAFRANY, S.T. 465P BALL, M.T., BUNCE, K.T. Studies on the relaxant & SPRAGGS, C.F. effects of phorbol Neuronal and non- diacetate on guinea-pig neuronal 5-HT receptors airways smooth muscle. control electrolyte secretion in rat isolated ileal mucosa. 466P BALL, M.T., BUNCE, K.T. 468P ALTINEL, A., SUER, & GUNNING, S.J. A.H., TUGWELL, A.C. & Investigation of the WALI, F.A. Tetanic 5-HT receptor type fade and recovery mediating secretion in profile of atracurium- rat colon. induced neuromuscular blockade in the rat 467P ALYAMI, A.M. & WOOD, D. diaphragm preparation. Calcium antagonism by in 469P WALI, F.A., DARK, C.H., guinea-pig ileum. ALTINEL, A. & JONES, C.J. The effect of glycopyrrolate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. 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470P BROWN, G.J. & DEWHURST, 472P BROWN, G.J., COLLINS, D.G. A computer- G.G.S. & DE T, D.G. assisted learning A computer-assisted program for teaching learning program for the electrocardiogram teaching neuromuscular to science pharmacology to undergraduates. undergraduates. 471P BASARAB-HORWATH, BROWN, G.J., DEWHURST, D.G. & HALL, J. Automated analysis of drug- induced convulsions.

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473P HEWSON, G., LEIGHTON, COX, B., PEARCE, R.J., G.E., HILL, R.G. & THORNBER, C.W. & HUGHES, J. 5-HT2 BLACKBURN, T.P. In receptors are involved vivo pharmacology of in -induced ICI 170,809 - a new anorexia in the rat. 5-HT2 antagonist. BLACKBURN, T.P., COX, TORTELLA, F.C., B., PEARCE, R.J. & ESCHEVARIA, E., PASTEL, THORNBER, C.W. In R.H., COX, B. & vitro pharmacology of BLACKBURN, T. P. ICI 170,809 - a new Differential effects of 5-HT2 antagonist. ICI 170,809 and ritanserin on 24h EEG sleep patterns in rats. 473P MARTIN, G.R. & LEFF, P. JACKSON, S., BAJKA, E., Non-surmountable LOVEDAY, M. & WILLIS, antagonist behaviour at A.L. Automated 5-HT2 receptors: acquisition and allosterism or hemi- transformation of equilibrium? platelet aggregation data, using commercial BIRCH, P.J., C.J. software and a portable GROSSMAN & HAYES, A.G. computer. Pharmacology of excitatory amino acid receptors in the rat hemisected spinal cord. P R E S E N T E D A T 0 X F 0 R D M E E T I N G 1 9 8 7

474P ARMAH, B.I., BEUTTLER & RAVENS, U. Antagonism of the positive inotropic effect of DPI 201-106 by its methyl- indole derivative (BDF 8784).