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Toward an Integrative Science of the Brain and Crime
BioSocieties https://doi.org/10.1057/s41292-019-00167-3 COMMENTARY Mind the gap: toward an integrative science of the brain and crime Eyal Aharoni1 · Nathaniel E. Anderson2 · J. C. Barnes3 · Corey H. Allen4 · Kent A. Kiehl2 © Springer Nature Limited 2019 In the recent article, Criminalizing the brain: Neurocriminology and the production of strategic ignorance, Fallin et al. (2018) argue that most neuroscientists working with antisocial populations are guilty of suppressing, obfuscating, and erasing legiti- mate social explanations for criminal behavior as part of a strategic attempt to tout their reductionist preconceptions of behavior and to advance their own professional, extra-scientifc agendas. While we applaud their call for greater inclusion of social/ contextual factors into neurocriminological research, we fnd that they overstate the case against neurocriminology and understate important eforts by this emerg- ing community to generate signifcant and cross-disciplinary contributions to the understanding of antisocial behavior. Learning to identify and avoid such mischar- acterizations is critical for the pursuit of much-needed interdisciplinary research and collaboration on the prediction, explanation, and remediation of antisocial behavior. By critically evaluating Fallin et al.’s claims, we hope to strike a conciliatory bal- ance, which is more likely to promote integration rather than antagonism between disciplines. Fallin and colleagues correctly describe biosocial criminology as an emerging discipline that integrates historically neglected biological factors and neuroscientifc methods in the study of antisocial behavior. Indeed, this paradigm has demonstrated the value of genetics (Brunner et al. 1993), physiology (Latvala et al. 2015), bio- chemistry (Coccaro et al. 1998), and neuroimaging (Anderson and Kiehl 2012) for * Eyal Aharoni [email protected] 1 Department of Psychology, Georgia State University, P.O. -
Guaiana, G., Barbui, C., Caldwell, DM, Davies, SJC, Furukawa, TA
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Explore Bristol Research Guaiana, G., Barbui, C., Caldwell, D. M., Davies, S. J. C., Furukawa, T. A., Imai, H., ... Cipriani, A. (2017). Antidepressants, benzodiazepines and azapirones for panic disorder in adults: a network meta-analysis. Cochrane Database of Systematic Reviews, 2017(7), [CD012729]. https://doi.org/10.1002/14651858.CD012729 Publisher's PDF, also known as Version of record Link to published version (if available): 10.1002/14651858.CD012729 Link to publication record in Explore Bristol Research PDF-document This is the final published version of the article (version of record). It first appeared online via Cochrane Library at https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012729/full . Please refer to any applicable terms of use of the publisher. University of Bristol - Explore Bristol Research General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Cochrane Database of Systematic Reviews Antidepressants, benzodiazepines and azapirones for panic disorder in adults: a network meta-analysis (Protocol) Guaiana G, Barbui C, Caldwell DM, Davies SJC, Furukawa TA, Imai H, Koesters M, Tajika A, Bighelli I, Pompoli A, Cipriani A Guaiana G, Barbui C, Caldwell DM, Davies SJC, Furukawa TA, Imai H, Koesters M, Tajika A, Bighelli I, Pompoli A, Cipriani A. Antidepressants, benzodiazepines and azapirones for panic disorder in adults: a network meta-analysis. Cochrane Database of Systematic Reviews 2017, Issue 7. -
Smoking Modulates Neuroendocrine Responses to Ipsapirone in Patients with Panic Disorder A
Smoking Modulates Neuroendocrine Responses to Ipsapirone in Patients with Panic Disorder A. Broocks, M.D., Ph.D., B. Bandelow, M.D., Ph.D., K. Koch, U. Bartmann, J. Kinkelbur, M.D., U. Schweiger, M.D., Ph.D., F. Hohagen, M.D., Ph.D., and G. Hajak, M.D., Ph.D. Reduced 5-HT1A-receptor responsiveness has been reported temperature. In comparison to placebo, administration of in patients with panic disorder(PD) and/or agoraphobia ipsapirone was associated with significant increases of (PDA). Although many of these patients are regular various psychological symptoms and plasma cortisol smokers, it has not been examined whether psychological or concentrations. The subgroup of PD patients who were neurobiological effects induced by the selective 5-HT1A- smokers showed significantly higher cortisol responses to receptor agonist, ipsapirone, are affected by the smoking ipsapirone than non-smokers. status of the patients. In conclusion, smoking status has to be taken into In order to clarify this question neuroendocrine account when assessing the responsiveness of 5-HT1A challenges with oral doses of ipsapirone (0.3 mg/kg) and receptors in patients with psychiatric disorders. The placebo were performed in 39 patients with PDA, and prevention of smoking during challenge sessions might not results were compared between patients who smoked (Ͼ10 be the ideal approach in heavy smokers, since sudden cigarettes per day, n ϭ 17) and patients who had been non- abstinence from smoking is likely to affect neurobiological smokers for at least two years (n ϭ 22). and possibly psychological responses to ipsapirone. Patients who were smokers (but did not smoke during [Neuropsychopharmacology 27:270–278, 2002] the challenge procedure) had significantly reduced baseline © 2002 American College of Neuropsychopharmacology. -
Serotonergic Modulation of Suicidal Behaviour: Integrating Preclinical Data with Clinical Practice and Psychotherapy
Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy Vasileios Boulougouris, Ioannis Malogiannis, George Lockwood, Iannis Zervas & Giuseppe Di Giovanni Experimental Brain Research ISSN 0014-4819 Exp Brain Res DOI 10.1007/s00221-013-3669-z 1 23 Your article is protected by copyright and all rights are held exclusively by Springer- Verlag Berlin Heidelberg. This e-offprint is for personal use only and shall not be self- archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com”. 1 23 Author's personal copy Exp Brain Res DOI 10.1007/s00221-013-3669-z SeroTONIN Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy Vasileios Boulougouris · Ioannis Malogiannis · George Lockwood · Iannis Zervas · Giuseppe Di Giovanni Received: 6 May 2013 / Accepted: 30 July 2013 © Springer-Verlag Berlin Heidelberg 2013 Abstract Many studies have provided important infor- with personality disorders), aiming to invite the reader to mation regarding the anatomy, development and func- integrate some aspects of the neurobiology of human sui- tional organization of the 5-HT system and the alterations cidal behaviour into a model of suicide that can be used in in this system that are present within the brain of the sui- a clinical encounter. -
Neuroscience, Law, and Ethics T
International Journal of Law and Psychiatry 65 (2019) 101459 Contents lists available at ScienceDirect International Journal of Law and Psychiatry journal homepage: www.elsevier.com/locate/ijlawpsy Introduction Neuroscience, Law, and Ethics T In his influential Hardwired Behavior: What Neuroscience Reveals concerning the relevance of neurosciences to the law, especially crim- about Morality (2005), Laurence Tancredi combined neuroscience, inal law.” (Meynen, 2016, p. 3, Meynen, 2014; Morse & Roskies, 2013; psychology, philosophy, legal theory and clinical cases to insightfully Glenn & Raine, 2014; Chandler, 2018). One example is the use of examine the role of brain structure and function in moral behavior. neuroimaging to support behavioral evidence in judging whether a Analyzing how neurobiology shapes reasoning and decision-making, he person performing a criminal act met cognitive and volitional condi- discussed questions such as whether or to what extent we have free will tions necessary for criminal responsibility. Functional imaging re- and can be morally and criminally responsible for our actions. Is our cording abnormal activity in prefrontal-limbic pathways may indicate behavior hardwired and thus determined by the brain? Is free will an impaired cognitive and emotional processing and impaired capacity to illusion? Can mental content be explained entirely in terms of neural deliberate and consider the consequences of what one does or fails to content? If the brain influences but does not determine behavior, then do. This and other forms of imaging may eventually offer a more fine- how much of what we think and do is up to us? In his new book, grained account of impaired inhibitory mechanisms in the brain. -
5-HT1A Receptor Agonist Affects Fear Conditioning Through Stimulations of the Postsynaptic 5-HT1A Receptors in the Title Hippocampus and Amygdala
5-HT1A receptor agonist affects fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the Title hippocampus and amygdala Author(s) Li, XiaoBai; Inoue, Takeshi; Abekawa, Tomohiro; Weng, ShiMin; Nakagawa, Shin; Izumi, Takeshi; Koyama, Tsukasa European Journal of Pharmacology, 532(1-2), 74-80 Citation https://doi.org/10.1016/j.ejphar.2005.12.008 Issue Date 2006-02-17 Doc URL http://hdl.handle.net/2115/8408 Type article (author version) File Information EJP22907revisedFinal.pdf Instructions for use Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP 5-HT1A receptor agonist affects fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the hippocampus and amygdala. XiaoBai Lia, b, Takeshi Inouea, Tomohiro Abekawaa, ShiMin Weng b, Shin Nakagawaa, Takeshi Izumia, Tsukasa Koyamaa a Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan bShanghai Mental Health Center, 600, Wan Ping Nan Lu, Shanghai 200030, China Correspondence to: Takeshi Inoue, MD, PhD, Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan. Tel: +81-11-706-5160; Fax: +81-11-706-5081; E-mail: [email protected] Abstract Evidence from preclinical and clinical studies has shown that 5-HT1A receptor agonists have anxiolytic actions. The anxiolytic actions of 5-HT1A receptor agonists have been tested by our previous studies using fear conditioning. However, little is known about the brain regions of anxiolytic actions of 5-HT1A receptor agonists in this paradigm. In the present study, we investigated the effects of bilateral microinjections of flesinoxan, a selective 5-HT1A receptor agonist, into the hippocampus, amygdala and medial prefrontal cortex on the expression of contextual conditioned freezing and the defecation induced by conditioned fear stress in rats. -
The New BRAIN
SPECIAL EDITION The New BRAIN MACLEAN’S EBOOK Contents Introduction Join us for a giant brainstorming session on what the world’s neuroscience superstars are keeping top of mind The glia club Once dismissed as ‘glue,’ glial cells, neuron’s little brother, have become the lodestone of brain research. But is it a good idea for scientists to herd in one direction? Charlie Gillis How to build a brain A philosopher and engineer has created the most complex simulated brain in the world. On $30,000 a year. Nick Taylor-Vaisey Mad beauty A conceptual photographer dusts off the jars of a brain collection from a Texas mental hospital David Graham They grow up so fast The latest research on a baby’s remarkable brain development, from recognizing right and wrong to the gift of memory Rosemary Counter Gone baby gone Why don’t we remember anything from earliest childhood? It’s called infantile amnesia. Emma Teitel MACLEAN’S EBOOK THE NEW BRAIN Memory and gender Emma Teitel The young and the restless No one knows why autistic kids are often night owls, but their parents can take heart: science is looking at some biological causes based in the brain Katherine DeClerq Crying out for attention How one psychologist is offering hope to parents worried about the stigma, safety and side effects of ADHD medication Hannah Hoag Mind the age gap Previously dismissed as lesser or defective, new research is revealing that the teenage brain is just as powerful as any adult’s Rosemary Counter No brawn, no brains Genetics may decide your upper and lower limits for cognitive -
Clinical Utility of Vilazodone for the Treatment of Adults with Major Depressive Disorder and Theoretical Implications for Future Clinical Use
Neuropsychiatric Disease and Treatment Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use Mandeep Singh Background: Vilazodone is the latest approved antidepressant available in the United States. Thomas L Schwartz Its dual mechanism of action combines the inhibition of serotonin transporters while simultane- ously partially agonizing serotonin-1a (5-HT1A) receptors. This combined activity results in SUNY Upstate Medical University, Psychiatry Department, Syracuse, serotonin facilitation across the brain’s serotonergic pathways, which has been termed by the NY, USA authors as that of a serotonin partial agonist and reuptake inhibitor, or SPARI. Objective: The authors to review laboratory, animal model data, and human trial data to synthesize a working theory regarding the mechanism of antidepressant action of this agent and regarding its potential for additional indications. Methods: A MEDLINE and Internet search was conducted and the resultant evidence For personal use only. reviewed. Results: Vilazodone has randomized, controlled empirical data which has garnered it an approval for treating major depressive disorder. It combines two well-known pharmacodynamic mechanisms of serotonergic action into a novel agent. Although no head-to-head studies against other antidepressants are published, the efficacy data for vilazodone appears comparable to other known antidepressants, with associated gastrointestinal side effects similar to serotonin selective reuptake inhibitor and serotonin norepinephrine reuptake inhibitor antidepressants, but potentially with a lower incidence of sexual side effects and weight gain. Discussion: As a new option for the treatment of major depressive disorder, vilazodone, due to its unique SPARI mechanism of action, may hold promise for patients who cannot tolerate or have not responded to previous antidepressant monotherapies. -
Tanksley, J.C
Identifying psychological pathways to polyvictimization: evidence from a longitudinal cohort study of twins from the UK Peter T. Tanksley, J.C. Barnes, Brian B. Boutwell, Louise Arseneault, Avshalom Caspi, Andrea Danese, Helen L. Fisher, et al. Journal of Experimental Criminology ISSN 1573-3750 J Exp Criminol DOI 10.1007/s11292-020-09422-1 1 23 Your article is protected by copyright and all rights are held exclusively by Springer Nature B.V.. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com”. 1 23 Author's personal copy Journal of Experimental Criminology https://doi.org/10.1007/s11292-020-09422-1 Identifying psychological pathways to polyvictimization: evidence from a longitudinal cohort study of twins from the UK Peter T. Tanksley1 & J.C. Barnes1 & Brian B. Boutwell2,3 & Louise Arseneault4 & Avshalom Caspi4,5,6,7 & Andrea Danese4,8 & Helen L. Fisher4 & Terrie E. Moffitt4,5,6,7 # Springer Nature B.V. 2020 Abstract Objectives Examine the extent to which cognitive/psychological characteristics predict later polyvictimization. We employ a twin-based design that allows us to test the social neurocriminology hypothesis that environmental factors influence brain-based charac- teristics and influence behaviors like victimization. -
Neuroimaging Abnormalities in Neurological Patients with Criminal Behavior
Current Neurology and Neuroscience Reports (2018) 18:47 https://doi.org/10.1007/s11910-018-0853-3 BEHAVIOR (H S KIRSHNER, SECTION EDITOR) Neuroimaging Abnormalities in Neurological Patients with Criminal Behavior R. Ryan Darby1 # Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Purpose of Review Criminal behavior occurs in previously law-abiding neurological patients, including patients with traumatic brain injury, focal brain lesions, and dementia. Neuroimaging abnormalities in these patients allow one to explore the potential neuroanatomical correlates of criminal behavior. However, this process has been challenging because (1) It is difficult to determine the temporal relationship between criminal behavior and neurological disease onset; (2) Abnormalities in several different brain regions have been associated with criminal behavior; and (3) It is difficult to quantify neuroimaging abnormalities in individual subjects. Recent Findings Recent studies have begun to address these concerns, showing that neuroimaging abnormalities in patients with criminal behavior localize to a common brain network, rather than a single specific brain region. New methods have been developed to identify atrophy patterns in individual patients, but have not yet been used in neurological patients with criminal behavior. Summary Future advances will be important for making sure that neuroimaging data is used in a responsible manner in legal cases involving criminal behavior. Keywords Criminal . Moral . Brain lesions . Neurology . Frontal lobe . Brain networks Introduction he was killed by police [2]. At autopsy, he was found to have a malignant tumor in his right temporal lobe, prompting ques- Neurological diseases can cause profound changes to behav- tions about the degree to which his brain injury contributed to ior. -
A Brief Summary for 5-HT Receptors
ndrom Sy es tic & e G n e e n G e f T o Watry and Lu, J Genet Syndr Gene Ther 2013, 4:2 Journal of Genetic Syndromes h l e a r n a r p DOI: 10.4172/2157-7412.1000129 u y o J & Gene Therapy ISSN: 2157-7412 Short Commentary Open Access A Brief Summary for 5-HT Receptors Watry S and Lu J* Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA As a group of G protein-coupled receptors (GPCRs) and ligand- (Anpirtoline) [42]; CGS 12066B [43]; SB 216641 [44]; RU 24969 [45]; gated ion channels (LGICs), the serotonin (5-HT) receptors are CP 93129 [46]. found in the central and peripheral nervous systems. After activated Application value: Depression [47]; Anxiety [48]; Aggression by the neurotransmitter serotonin, their natural ligand, 5-HT [49]; Migraine [50]; Drug Addicton [51]; increased locomotor activity receptors mediate both excitatory and inhibitory neurotransmission [52]; brain reward mechanisms (agonist); Alcoholism [53]; Sleep [54]; by modulating the release of many neurotransmitters, including hypothermia [55]. glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, Receptor: 5-HT 1D [56] vasopressin, cortisol, corticotropin, and substance P, among others. 5-HT receptors influence various biological and neurological processes Structure: GPCR [56]. such as aggression, anxiety, appetite, cognition, learning, memory, Localization: Raphe nuclei; Cortex, Caudate, Globus Pallidus mood, nausea, sleep, and thermoregulation. Accordingly, 5-HT [57]; Basal Ganglia, Substantia Nigra, Hippocampal Formation, receptors are the target of a variety of pharmaceutical drugs, including Raphe Nuclei [58]; Caudate Nucleus, Lateral Geniculate Nuclei, Spinal many antidepressants, antipsychotics, anorectics, antiemetics, Trigominal Nucleus [32]; Globus Pallidus [59]. -
The Neurobiology of Violence: Biological Roots of Crime
The Neurobiology of Violence: Neurocriminology CHARLES J. VELLA, PHD APRIL 9, 2015 THANKS TO ADRIAN RAINE, CHRISTOPHER M. FILLEY, KENT KIEHL This presentation is based on these books The Anatomy of Violence: The Psychopath The Biological Roots of Crime Whisperer by Adrian Raine by Kent Kiehl 2013 2015 Punishment of crime We should know the difference between who we are angry at and who we are afraid of. Protection for society: We need to segregate from society those of whom we are afraid Rehabilitation: We need to rehabilitate those with whom we are angry Aspen Neurobehavioral Conference Consensus Statement (Filley et al. Neuropsychiatry Neuropsychol Behav Neurol 2001; 14: 1-14) Working group representing neurology, psychiatry, neuropsychology, trauma surgery, nursing, evolutionary psychology, ethics, and law Aggression can be adaptive, but violence is a an aggressive act characterized by the unwarranted infliction of physical injury Violence can result from brain dysfunction, although social and evolutionary factors also contribute Study of neurobehavioral aspects – frontal lobe dysfunction, altered serotonin metabolism, and the influence of heredity – promises to lead to deeper understanding NGRI: Not Guilty by reason of insanity Not guilty by reason of insanity (NGRI) is a verdict issued in criminal cases whereby the defendant, determined to be legally insane, is held not responsible for his or her criminal actions The legal test of insanity, the right and wrong test as stated in the M’Naghten case (1843): did not know