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New Drugs Reviewed by CPG January 23, 2017 (Original New Drug Applications: FDA) Generic Name Trade Name Indication(s) CPG Action Immune globulin Cuvitru Biologic and In accordance with subcutaneous Immunological the SCA [human] 20% solution Agents/Immune Globulins/ Immune Globulin (Human) subcutaneous. Indicated as replacement for primary humoral immunodeficiency in adult and pediatric patients age two and older. eteplirsen Exondys 51 Central Nervous System In accordance with Agents/Antisense the SCA Oligonucleotides. Treatment of patients who have a confirmed mutation of the dystrophin gene amenable to exon 51 skipping. First drug approved for reatment of patients with Duchenne muscular dystrophy. levonorgestrel- Kyleena Endocrine and May prescribe releasing intrauterine Metabolic Agents/sex system 19.5 mg homones/contraceptive Hormones. Prevention of pregnancy for up to five years. **Phentermine Lomaira Central Nervous System In accordance with hydrochloride 8 mg Agents/ the SCA anorexiants/sympathomi metic anorexiants. Short term use weight reduction in adults with **(new formulation at an initial BMI of 30 or lower dosage) more or 27 with at least one weight-related condition. 1 New Drugs January 2017 canaglifozin/ Invokamet XR Endocrine and May prescribe metformin HCL Metabolic Agents/ extended-release antidiabetic agents/antidiabetic combination products. Treatment of adults with type 2 diabetes as an adjunct to diet and exercise. Adalimumab-atto Amjevita Biologic and In accordance with Immunological Agents/ the SCA Immunologic Agents/Immunomodulat ors/Tumor necrosis Factor-Alpha Blockers. Indicated for treatment of adults with: rheumatoid arthritis, psoriatic arthritis,ankylosing spondylitis, Crohn disease, ulcerative colitis, and plaque psoriasis. Also indicated for juvenile idiopathic arthritis in pts age 4 years and older. Flublok Quadravalent Biologic and May prescribe Immunological Agents/agents for active immunization/vaccines, viral. Protects against 4 straing of influence, 3 of the same strains found in trivalent Flublok as well as an additional B strain. Approved for adults age 18 and older. 2 New Drugs January 2017 olaratumab Lartuvo Antineoplastic May not prescribe Agents/monoclonal antibodies. For use in combination with doxorubicin for the treatment of adult patients with soft tissue sarcoma with a histologic subtype for which an anthracycline- containing regiment is appropriate and which is not amenable to curative treatment with radiotherapy or surgery. bezlotoxumab Zinplava Biologic and May prescribe Immuniclogical Agents/ monocolonal antibodies (biologic/immunologic). Reduces recurrence of C-diff infection in patients age 18 and older who are receiving antibacterial drug treatment of C-diff an are at high risk for recurrence. tenofovir alafenamide Vemlidy Anti-infective Agents/ May prescribe antiretroviral agents/nucleotide analog reverse transcriptase inhibitors. Treatment of chronic hepatitis B infection in adults with compensated liver disease. DHEA Intrarosa Endocrine and May prescribe Metabolic Agents/ sex homones. Treatment of postmenopausal moderate to severe dyspareunia. 3 New Drugs January 2017 Insulin Soliqua Endocrine and May prescribe glargine/lixisenatide Metabolic Agents/antidiabetic agents/insulin combination. Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes inadequately controlled on basal insulin or lixisenatide. SMOFlipid Nutrients and Nutritional May prescribe Agents/intravenous nutritional therapy/lipids. Source of calories, essential fatty acids, and omega-3 fatty acids for adults requiring parenteral nutrition. Eucrisa Crisaborole 2% Dermatological agents/ May prescribe phosphodiesterase-4 inhibitors. Topical treatment of mild to moderate atopic dermatitis in patients age 2 years and older. rucaparib Rubraca Antineoplastic In accordance with Agents/PARP Enzymes the SCA Inhibitor. Approved for treatment of ovarian cancer. nusinersen Spinraza Central Nervous System In accordance with Agents/Antisense the SCA Oligonucleotides. Treatment of spinal muscular atrophy. 4 New Drug Indications/ Warnings Reviewed by CPG January 23, 2017 (New Drug Indications/ Boxed Warnings: FDA) Generic Name Trade Name Therapeutic Category CPG Action canakinumab Ilaris Biologic and Immunological Current: In Agents; immunologic agents; accordance with the (expanded indication) immunomodulators SCA January 23, 2017: No change ustekinumab Stelara Biologic and Immunological Current: In Agents;immunologic agents; accordance with the immunomodulators SCA (expanded indication) January 23, 2017: No change idelalisib Zydelig Antineoplastic Agents; Kinase Current: May not Inhibitors; phosphatidylinositol 3- prescribe (expanded black box kinase inhibitors warning) January 23, 2017: No change lumacaftor/ Orkambi Endocrine and Metabolic Agents; Current: In ivacaftor cystic fibrosis transmembrane accordance with the regulator protein SCA (expanded indication) January 23, 2017: No change eltrombopag Promacta Hemotologic Agents; Current: In hematopoietic agents; accordance with the (expanded boxed thrombopoietin receptor agonist SCA warning) January 23, 2017: No change atezolizumab Tecentriq Antineoplastic agents; monoclonal Current: May not (expanded indication) antibodies (antineoplastic) prescribe January 23, 2017: No change paricalcitol Zemplar Nutrients and Nutritional Agents; Current: May vitamins; fat-soluble vitamins; prescribe (expanded indication) vitamin D January 23, 2017: No change 1 New Drug Indications January 2017 pembrolizumab Keytruda Biologic and Immunological Current: May not Agents; immunologic agents; prescribe (expanded indication) immunomodulators January 23, 2017: No change etanercept Enbrel Biologic and Immunological Current: In Agents; immunologic agents; accordance with the immunomodulators; tumor SCA (expanded indication) necrosis factor-alpha blockers (TNF-alpha blockers) January 23, 2017: No change daratumumab Darzalex Antineoplastic Agents; Current: May not monoclonoal antibodies prescribe (expanded indication) (antineoplastic) January 23, 2017: No change flu vaccine FluLaval Biologic and Immunological Current: May Quadrivalent Agents/ Agents for Active prescribe (expanded indication) Immunization/vaccine, viral. January 23, 2017 No change sevelamer carbonate Renvela Renal and Genitourinary Agents/ Current: May Phosphate Binders. prescribe (expanded indication) January 23, 2017: No change empagliflozin Jardiance Endcrine and Metabolic Agents/ Current: May Antidiabetic Agents/ sodium- prescribe glucose co-transporter 2 (expanded indication) inhibitors. January 23, 2017: No change hyaluronic acid Restylane Central Nervous System Agents/ Current: May Refyne physical adjuncts/hyaluronic acid prescribe derivatives, dermal. (expanded indication) January 23, 2017: No change hyaluronic Acid Restylane Central Nervous System Agents/ Current: May Defyne physical adjuncts/hyaluronic acid prescribe derivatives, dermal. (expanded indication) January 23, 2017: No change degludec and Tresiba and Endocrine and Metabolic Agents/ Current: May degludec/insulin Ryzodeg 70/30 Antidiabetic Agents/Insulin. prescribe aspart (expanded indication) January 23, 2017: No change 2 New Drug Indications January 2017 chlorazepate Tranxene T- Central Nervous System Agents/ Current: may dipotassium Tab Benzodiazepines. prescribe (boxed warning) January 23, 2017: No change temazepam Restoril Central Nervous System Agents/ Current: May Benzodiazepines. prescribe (boxed warning) January 23, 2017: No change tramadol Utram Central Nervous System Agents/ Current: May hydrochloride Opioid Analgesics. prescribe (boxed warning) January 23, 2017: No change antihemophilic factor Adynovate Hemotological Current: In [recombinant], Agents/Antihemophilic accordance with the pegolated Agents/Antihemophilic Factor SCA (Factor VIII:AHF). (expanded indication) January 23, 2017: No change nalbuphine Nubain Central Nervous System Agents/ Current: May hydrochloride Opioid Agonist-Antagonist prescribe Analgesics. (boxed warning) January 23, 2017: No change Diazepam Valium Central Nervous System Agents/ Current: May Benzodiazepines. prescribe (boxed warning) January 23, 2017: No change oxymorphone Opana Central Nervous System Current: Subject to hydrochloride Agents/Opioid Analgesics. Schedule II restrictions/ (expanded indication) formulary January 23, 2017: No change fentanyl citrate Fentanyl Central Nervous System Current: Subject to Agents/Opioid Analgesics. Subject to Scheduel (boxed warning) II restrictions/ formulary January 23, 2017: No change pentazocine Talwin Central Nervous System Agents/ Current: May Opioid Agonist-Antagonist prescribe (boxed warning) Analgesics. January 23, 2017: No change 3 New Drug Indications January 2017 Merperidine Demerol Central Nervous System Agents/ Current: subject to hydrochloride Opioid Analgesics. Schedule II prescribing (boxed warning) restrictions/ formulary January 23, 2017: No change chlordizepoxide Librium Central Nervous System Agents/ Current: May hydrochloride Benzodiazepines. prescribe (boxed warning) January 23, 2017: No change empaglifozin/ Glyxambi Endocrine and Metabolic Agents/ Current: May Linagliptin Antidiabetic Agents/ Antidiabetic prescribe Combination products. (expanded indication) January 23, 2017: No change Sufentanil citrate Central Nervous System Current: subject to Agents/Opioid Analgesics. schedule II (boxed warning) prescribing restrictions/ formulary January 23, 2017: No change oxycodone Percodan Central Nervous System Current: subject
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  • SUPPLEMENTARY FILE Cellular Fitnessphenotype of Cancer Target

    SUPPLEMENTARY FILE Cellular Fitnessphenotype of Cancer Target

    SUPPLEMENTARY FILE Cellular FitnessPhenotype of Cancer Target Genes in Cancer Therapeutics Bijesh George, P. Mukundan Pillai, Aswathy Mary Paul, Revikumar Amjesh, Kim Leitzel, Suhail M. Ali, Oleta Sandiford, Allan Lipton, Pranela Rameshwar, Gabriel N. Hortobagyi, Madhavan Radhakrishna Pillai, and Rakesh Kumar Supplementary Figures Supplementary Figure S1: Fitness-dependency of cellular targets of approved oncology drugs in cancer cell lines. A, Distribution of alterations in the cellular fitness in esophageal cancer cell lines upon selective knockdown of FSPS test gene. The values are plotted as boxplots with positive and negative changes in the cellular fitness for each cell line, represented by a single dot. B, Effect of knocking down of indicated targets in Head and Neck carcinoma cell lines. C, Distribution of 47 cancer targets of FDA-approved drugs, including, a subset of its 15 priority therapeutic targets in across cancer- types for which drugs targeting these cellular targets are approved. D, Distribution of 47 fitness targets across 19 cancer types for which drugs targeting these molecules are approved corresponds to the loss of Fitness score for were taken from Cancer Dependency Map (23). Supplementary Figure S2: Cellular targets of approved oncology drugs as excellent fitness genes in cancer-types for which drugs targeting these are not approved. Distribution of 43 cellular fitness genes with a significant loss of cellular fitness upon their depletion across peripheral nervous system, large intestine and ovarian cell lines