Chemotherapy Medications

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UnityPoint at Home Specialty Pharmacy Chemotherapy & Supportive Care Agents This is an alphabetical listing of specialty medications that UnityPoint at Home Specialty Pharmacy can provide or facilitate access to and is subject to change Last Reviewed: February 2019 BREAST LUNG OVARIAN Afinitor® (Everolimus) Hycamtin® (Topotecan) Hexalen® (Altretamine) Afinitor Disperz® Iressa® (Gefitinib) Lynparza™ (Olaparib) (Everolimus) Lorbrena® (Lortatinib) Aromasin® (Exemestane) Mekinist® (Trametinib) OTHER Exemestane Tafinlar® (Dabrafenib) Afinitor® (Everolimus) ® Fareston (Toremifene) Tagrisso™ (Osimertinib) Capecitabine Faslodex® (Fulvestrant) Talzenna® (Talazoparib) Gleevec® (Imatinib) Ibrance® (Palbociclib) Tarceva® (Erlotinib) Gleostine (Lomustine) Nerlynx® (Neratinib) Vizimpro® (Dacomitinib) Imatinib Kisqali® (Ribociclib) Xalkori® (Crizotinib) Lomustine Kisqali-Femara Co-Pack® Zykadia® (Ceritinib) Lysodren® (Mitotane) (Ribociclib-Letrozole) Stivarga® (Regorafenib) Tykerb® (Lapatinib) MELANOMA/BASAL CELL Sutent® (Sunitinib) Verzenio® (Abemaciclib) Odomzo® (Sonidegib) Tarceva® (Erlotinib) Xgeva® (Denosumab) Mekinist® (Trametinib) Temodar® (Temozolomide) Zortress® (Everolimus) Sylatron™ (Peginterferon alfa Temozolomide 2b) Votrient® (Pazopanib) HEMATOLOGIC Tafinlar® (Dabrafenib) Xeloda® (Capecitabine) Bosulif® (Bosutinib) Zejula® (Niraparib) Calquence® (Acalabrutinib) PROSTATE & RENAL CELL Zortress® (Everolimus) Farydak® (Panobinostat) Afinitor® (Everolimus) Daurismo® (Glasdegib) Afinitor Disperz® SUPPORTIVE CARE AGENTS Gleevec® (Imatinib) (Everolimus) Aranesp® (Darbepoetin alfa) Gleostine (Lomustine) Cabometyx® (Cabozantinib) Bexarotene Imatinib Cometriq® (Cabozantinib) Epogen® (Epoetin alfa) Lomustine Eligard® (Leuprolide) Granix® (TBO Filgrastim) Ninlaro® (Ixazomib) Erleada® (Apalutamide) Jadenu® (Deferasirox) Rydapt® (Midostaurin) Inlyta® (Axitinib) Leukine® (Sargramostim) Sprycel® (Dasatinib) Leuprolide acetate Neulasta® (Pegfilgrastim) Tasigna® (Nilotinib) Lupron Depot® (Leuprolide) Neupogen® (Filgrastim) Tretinoin Nexavar® (Sorafenib) Octreotide Vidaza® (Azacitidine) Nilutamide Procrit® (Epoetin alfa) Xgeva® (Denosumab) Sutent® (Sunitinib) Promacta® (Eltrombopag) Zydelig® (Idelalisib) Trelstar® (Triptorelin pamoate) Targretin® (Bexarotene) Vantas® (Histrelin) Varubi® (Rolapitant) Votrient® (Pazopanib) Zarxio® (Filgrastim-sndz) Zoladex® (Goserelin acetate) Zytiga® (Abirateron) Is there a medication not listed above? Contact UnityPoint at Home Specialty Pharmacy to see if our pharmacy can facilitate access to the medication! Contact us Today! UnityPoint at Home Specialty Pharmacy 11333 Aurora Avenue Urbandale, IA 50322 Ph: 515-557-3110 Fax: 855-806-7285 .

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Cancer Drug Pharmacology Table
CANCER DRUG PHARMACOLOGY TABLE Cytotoxic Chemotherapy Drugs are classified according to the BC Cancer Drug Manual Monographs, unless otherwise specified (see asterisks). Subclassifications are in brackets where applicable. Alkylating Agents have reactive groups (usually alkyl) that attach to Antimetabolites are structural analogues of naturally occurring molecules DNA or RNA, leading to interruption in synthesis of DNA, RNA, or required for DNA and RNA synthesis. When substituted for the natural body proteins. substances, they disrupt DNA and RNA synthesis. bendamustine (nitrogen mustard) azacitidine (pyrimidine analogue) busulfan (alkyl sulfonate) capecitabine (pyrimidine analogue) carboplatin (platinum) cladribine (adenosine analogue) carmustine (nitrosurea) cytarabine (pyrimidine analogue) chlorambucil (nitrogen mustard) fludarabine (purine analogue) cisplatin (platinum) fluorouracil (pyrimidine analogue) cyclophosphamide (nitrogen mustard) gemcitabine (pyrimidine analogue) dacarbazine (triazine) mercaptopurine (purine analogue) estramustine (nitrogen mustard with 17-beta-estradiol) methotrexate (folate analogue) hydroxyurea pralatrexate (folate analogue) ifosfamide (nitrogen mustard) pemetrexed (folate analogue) lomustine (nitrosurea) pentostatin (purine analogue) mechlorethamine (nitrogen mustard) raltitrexed (folate analogue) melphalan (nitrogen mustard) thioguanine (purine analogue) oxaliplatin (platinum) trifluridine-tipiracil (pyrimidine analogue/thymidine phosphorylase procarbazine (triazine) inhibitor)
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The Synergic Effect of Vincristine and Vorinostat in Leukemia in Vitro and In
Chao et al. Journal of Hematology & Oncology (2015) 8:82 DOI 10.1186/s13045-015-0176-7 JOURNAL OF HEMATOLOGY & ONCOLOGY RESEARCH ARTICLE Open Access The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo Min-Wu Chao1, Mei-Jung Lai2, Jing-Ping Liou3, Ya-Ling Chang1, Jing-Chi Wang4, Shiow-Lin Pan4*† and Che-Ming Teng1*† Abstract Background: Combination therapy is a key strategy for minimizing drug resistance, a common problem in cancer therapy. The microtubule-depolymerizing agent vincristine is widely used in the treatment of acute leukemia. In order to decrease toxicity and chemoresistance of vincristine, this study will investigate the effects of combination vincristine and vorinostat (suberoylanilide hydroxamic acid (SAHA)), a pan-histone deacetylase inhibitor, on human acute T cell lymphoblastic leukemia cells. Methods: Cell viability experiments were determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, and cell cycle distributions as well as mitochondria membrane potential were analyzed by flow cytometry. In vitro tubulin polymerization assay was used to test tubulin assembly, and immunofluorescence analysis was performed to detect microtubule distribution and morphology. In vivo effect of the combination was evaluated by a MOLT-4 xenograft model. Statistical analysis was assessed by Bonferroni’s t test. Results: Cell viability showed that the combination of vincristine and SAHA exhibited greater cytotoxicity with an IC50 value of 0.88 nM, compared to each drug alone, 3.3 and 840 nM. This combination synergically induced G2/M arrest, followed by an increase in cell number at the sub-G1 phase and caspase activation.
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List of Drugs Not Repackaged by Safecor Health
Drugs Not Repackaged by Safecor Health The following tables list specific medications that are not repackaged by Safecor Health due to regulatory restrictions or specific manufacturer requirements. The items not repackaged are alphabetically listed below, both by brand name (table 1) and generic name (table 2). Please note: Safecor Health cannot repackage any beta lactam antibiotics (such as penicillins, amoxicillin and cephalosporins) or potent chemotherapeutic agents. Also, due to FDA restrictions, we cannot repackage half- or quarter-tabs, compounded or diluted drugs, powders, and ointments or creams. Safecor Health can repackage most hazardous drugs on the NIOSH list. Contact us for a complete list of hazardous drugs repackaged by Safecor Health. Table 1. Do Not Repackage Drugs Sorted Alphabetically by Brand Name Brand Name(s) Generic Name(s) Reason Item Cannot Be Repackaged Adrucil Fluorouracil Potent chemotherapy agent Aspirin and Extended-Release Specific manufacturer recommendations for very Aggrenox Dipyridamole limited expiration dating Albenza Albendazole Cost per dose prohibitive Alkeran Melphalan Potent chemotherapy agent Augmentin Amoxicillin and Clavulanate Potassium Safecor Health does not repackage this drug class Manufacturer states, "dispense in original container," Belsomra Suvorexant on the drug label Manufacturer states, "dispense in original container," Biktarvy Bictegravir, Emtricitabine and Tenofovir Alafenamide on the drug label Bion Tears Dextran, Hypromellose Ophthalmic Drops Sterile and unpreserved CeeNU Lomustine
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Emetogenic Potential of Antineoplastic Agents
EMETOGENIC POTENTIAL OF ANTINEOPLASTIC AGENTS High Risk (>90% frequency without antiemetics) • AC combination: Doxorubicin or Epirubicin (Ellence) ϩ • Doxorubicin IV: >60mg/m 2 Cyclophosphamide (Cytoxan) IV • Epirubicin (Ellence) IV: >90mg/m 2 • Altretamine (HMM, Hexalen) oral • Ifosfamide (Ifex) IV: Ն2g/m 2 per dose • Carmustine (BCNU, BiCNU) IV: Ͼ250mg/m 2 • Mechlorethamine (Mustargen) IV • Cisplatin (CDDP) IV • Procarbazine (Matulane) oral • Cyclophosphamide (CTX, Cytoxan) IV: Ͼ1,500mg/m 2 • Streptozocin (Zanosar) IV • Dacarbazine (DTIC, DTIC-Dome) IV Moderate Risk (30–90% frequency without antiemetics) 2 2 • Aldesleukin (IL-2, Proleukin) IV: Ͼ12–15 million IU/m • Doxorubicin IV: Յ60mg/m 2 2 • Amifostine (Ethyol) IV: Ͼ300mg/m • Epirubicin (Ellence) IV: Յ90mg/m • Arsenic trioxide (As2 O3 , Trisenox) IV • Estramustine (Emcyt) oral • Azacitidine (Vidaza) IV • Etoposide (VP-16) oral • Bendamustine (Treanda) IV • Idarubicin (Idamycin) IV • Busulfan (Busulfex) IV ; oral: Ͼ4mg/day • Ifosfamide (Ifex) IV: Ͻ2g/m 2 • Carboplatin IV • Interferon alpha (IFN-alfa, Intron A) IV: Ն10 million IU/m 2 • Carmustine (BCNU, BiCNU) IV: Յ250mg/m 2 • Irinotecan (CPT-11, Camptosar) IV • Clofarabine (Clolar) IV • Lomustine (CCNU, CeeNU) oral • Cyclophosphamide (CTX, Cytoxan) IV: Յ1,500mg/m 2 • Melphalan (L-PAM, Alkeran) IV • Cyclophosphamide (CTX) oral Ն100mg/m 2 /day • Methotrexate (MTX) IV: Ն250mg/m 2 • Cytarabine (ARA-C) IV: Ͼ200mg/m 2 • Oxaliplatin (Eloxatin) IV • Dactinomycin (Cosmegen) IV • Temozolomide (Temodar) IV; oral Ͼ75mg/m 2 /day • Daunorubicin
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Original New Drug Applications
New Drugs Reviewed by CPG January 23, 2017 (Original New Drug Applications: FDA) Generic Name Trade Name Indication(s) CPG Action Immune globulin Cuvitru Biologic and In accordance with subcutaneous Immunological the SCA [human] 20% solution Agents/Immune Globulins/ Immune Globulin (Human) subcutaneous. Indicated as replacement for primary humoral immunodeficiency in adult and pediatric patients age two and older. eteplirsen Exondys 51 Central Nervous System In accordance with Agents/Antisense the SCA Oligonucleotides. Treatment of patients who have a confirmed mutation of the dystrophin gene amenable to exon 51 skipping. First drug approved for reatment of patients with Duchenne muscular dystrophy. levonorgestrel- Kyleena Endocrine and May prescribe releasing intrauterine Metabolic Agents/sex system 19.5 mg homones/contraceptive Hormones. Prevention of pregnancy for up to five years. **Phentermine Lomaira Central Nervous System In accordance with hydrochloride 8 mg Agents/ the SCA anorexiants/sympathomi metic anorexiants. Short term use weight reduction in adults with **(new formulation at an initial BMI of 30 or lower dosage) more or 27 with at least one weight-related condition. 1 New Drugs January 2017 canaglifozin/ Invokamet XR Endocrine and May prescribe metformin HCL Metabolic Agents/ extended-release antidiabetic agents/antidiabetic combination products. Treatment of adults with type 2 diabetes as an adjunct to diet and exercise. Adalimumab-atto Amjevita Biologic and In accordance with Immunological Agents/ the SCA Immunologic Agents/Immunomodulat ors/Tumor necrosis Factor-Alpha Blockers. Indicated for treatment of adults with: rheumatoid arthritis, psoriatic arthritis,ankylosing spondylitis, Crohn disease, ulcerative colitis, and plaque psoriasis. Also indicated for juvenile idiopathic arthritis in pts age 4 years and older.
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SUPPLEMENTARY FILE Cellular Fitnessphenotype of Cancer Target
SUPPLEMENTARY FILE Cellular FitnessPhenotype of Cancer Target Genes in Cancer Therapeutics Bijesh George, P. Mukundan Pillai, Aswathy Mary Paul, Revikumar Amjesh, Kim Leitzel, Suhail M. Ali, Oleta Sandiford, Allan Lipton, Pranela Rameshwar, Gabriel N. Hortobagyi, Madhavan Radhakrishna Pillai, and Rakesh Kumar Supplementary Figures Supplementary Figure S1: Fitness-dependency of cellular targets of approved oncology drugs in cancer cell lines. A, Distribution of alterations in the cellular fitness in esophageal cancer cell lines upon selective knockdown of FSPS test gene. The values are plotted as boxplots with positive and negative changes in the cellular fitness for each cell line, represented by a single dot. B, Effect of knocking down of indicated targets in Head and Neck carcinoma cell lines. C, Distribution of 47 cancer targets of FDA-approved drugs, including, a subset of its 15 priority therapeutic targets in across cancer- types for which drugs targeting these cellular targets are approved. D, Distribution of 47 fitness targets across 19 cancer types for which drugs targeting these molecules are approved corresponds to the loss of Fitness score for were taken from Cancer Dependency Map (23). Supplementary Figure S2: Cellular targets of approved oncology drugs as excellent fitness genes in cancer-types for which drugs targeting these are not approved. Distribution of 43 cellular fitness genes with a significant loss of cellular fitness upon their depletion across peripheral nervous system, large intestine and ovarian cell lines
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How Chemotherapy Drugs Work
cancer.org | 1.800.227.2345 How Chemotherapy Drugs Work Many different kinds of chemotherapy or chemo drugs are used to treat cancer – either alone or in combination with other drugs or treatments. These drugs are very different in their chemical composition (what they are made of), how they are prescribed and given, how useful they are in treating certain types of cancer, and the side effects they might have. It's important to know that not all medicines and drugs to treat cancer work the same way. Other drugs to treat cancer work differently, such as targeted therapy1, hormone therapy, and immunotherapy2. The information below describes how traditional or standard chemotherapy works. Chemotherapy works with the cell cycle Every time any new cell is formed, it goes through a usual process to become a fully functioning (or mature) cell. The process involves a series of phases and is called the cell cycle. Chemotherapy drugs target cells at different phases of the cell cycle. Understanding how these drugs work helps doctors predict which drugs are likely to work well together. Doctors can also plan how often doses of each drug should be given based on the timing of the cell phases. Cancer cells tend to form new cells more quickly than normal cells and this makes them a better target for chemotherapy drugs. However, chemo drugs can’t tell the difference between healthy cells and cancer cells. This means normal cells are damaged along with the cancer cells, and this causes side effects. Each time chemo is given, it means trying to find a balance between killing the cancer cells (in order to cure or control the disease) and sparing the normal cells (to lessen side effects).
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The Antitumor Effects of an Arsthinol–Cyclodextrin Complex in A
The antitumor effects of an arsthinol–cyclodextrin complex in a heterotopic mouse model of glioma Selma Becherirat, Marie-Claire Lanhers, Marie Socha, Mehdi Yemloul, Alain Astier, Caroline Loboda, Nathalia Aniceto, Stéphane Gibaud To cite this version: Selma Becherirat, Marie-Claire Lanhers, Marie Socha, Mehdi Yemloul, Alain Astier, et al.. The antitumor effects of an arsthinol–cyclodextrin complex in a heterotopic mouse model of glioma. Eu- ropean Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2013, 83 (3 Pt A), pp.560-568. 10.1016/j.ejpb.2013.06.021. hal-01169157 HAL Id: hal-01169157 https://hal.archives-ouvertes.fr/hal-01169157 Submitted on 5 Jul 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. The antitumor effects of an arsthinol-cyclodextrin complex in an heterotopic mouse model of glioma Selma Becherirata, Marie-Claire Lanhersb, Marie Sochaa, Mehdi Yemloulc, Alain Astierd, Caroline Lobodaa, Nathalia Anicetoa and Stéphane Gibauda* a : EA 3452 – CITHEFOR – Université de Lorraine - 5, rue Albert Lebrun (Faculté de pharmacie) – 54000 Nancy - France b : EA 4421 – SIGRETO – Université de Lorraine - 9, avenue de la forêt de Haye (Faculté de médecine) – 54500 Vandœuvre-lès-Nancy - France c : Méthodologie RMN (CRM2, UMR 7036 CNRS-Nancy-Université), Faculté des Sciences et Technologies, BP 70239, 54506 Vandœuvre-lès-Nancy Cedex, France d : Pharmacy –Toxicology Department, CHU Henri Mondor, 51 avenue du Maréchal de Lattre, 94010, Créteil, France *Corresponding author.
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Cancer Drug Costs for a Month of Treatment at Initial Food and Drug
Cancer drug costs for a month of treatment at initial Food and Drug Administration approval Year of FDA Monthly Cost Monthly cost Generic name Brand name(s) approval (actual $'s) (2014 $'s) vinblastine Velban 1965 $78 $586 thioguanine, 6-TG Thioguanine Tabloid 1966 $17 $124 hydroxyurea Hydrea 1967 $14 $99 cytarabine Cytosar-U, Tarabine PFS 1969 $13 $84 procarbazine Matulane 1969 $2 $13 testolactone Teslac 1969 $179 $1,158 mitotane Lysodren 1970 $134 $816 plicamycin Mithracin 1970 $50 $305 mitomycin C Mutamycin 1974 $5 $23 dacarbazine DTIC-Dome 1975 $29 $128 lomustine CeeNU 1976 $10 $42 carmustine BiCNU, BCNU 1977 $33 $129 tamoxifen citrate Nolvadex 1977 $44 $170 cisplatin Platinol 1978 $125 $454 estramustine Emcyt 1981 $420 $1,094 streptozocin Zanosar 1982 $61 $150 etoposide, VP-16 Vepesid 1983 $181 $430 interferon alfa 2a Roferon A 1986 $742 $1,603 daunorubicin, daunomycin Cerubidine 1987 $533 $1,111 doxorubicin Adriamycin 1987 $521 $1,086 mitoxantrone Novantrone 1987 $477 $994 ifosfamide IFEX 1988 $1,667 $3,336 flutamide Eulexin 1989 $213 $406 altretamine Hexalen 1990 $341 $618 idarubicin Idamycin 1990 $227 $411 levamisole Ergamisol 1990 $105 $191 carboplatin Paraplatin 1991 $860 $1,495 fludarabine phosphate Fludara 1991 $662 $1,151 pamidronate Aredia 1991 $507 $881 pentostatin Nipent 1991 $1,767 $3,071 aldesleukin Proleukin 1992 $13,503 $22,784 melphalan Alkeran 1992 $35 $59 cladribine Leustatin, 2-CdA 1993 $764 $1,252 asparaginase Elspar 1994 $694 $1,109 paclitaxel Taxol 1994 $2,614 $4,176 pegaspargase Oncaspar 1994 $3,006 $4,802
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Clinical Policy: Nabilone (Cesamet), Dronabinol (Marinol, Syndros)
Clinical Policy: Nabilone (Cesamet), Dronabinol (Marinol, Syndros) Reference Number: CP.CPA.242 Effective Date: 11.16.16 Last Review Date: 11.17 Revision Log Line of Business: Medicaid See Important Reminder at the end of this policy for important regulatory and legal information. Description The following are synthetic cannabinoids requiring prior authorization: dronabinol (Marinol®, Syndros®), nabilone (Cesamet™) FDA approved indication Marinol Cesamet Syndros Controlled Substance Schedule Category CIII CII CII Treatment of nausea and vomiting associated with X X X cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments Treatment of Anorexia associated with weight loss X X in patients with acquired immune deficiency syndrome (AIDS) Policy/Criteria Provider must submit documentation (which may include office chart notes and lab results) supporting that member has met all approval criteria It is the policy of health plans affiliated with Centene Corporation® that Cesamet, Marinol, and Syndros are medically necessary when the following criteria are met: I. Initial Approval Criteria A. Nausea and Vomiting Associated with Cancer Chemotherapy (must meet all): 1. Diagnosis of nausea and vomiting associated with cancer chemotherapy; 2. Patient has received highly or moderately emetogenic chemotherapy; 3. Failure of a trial of a 5-HT3 serotonin antagonist (e.g. ondansetron), in combination with Emend® and dexamethasone unless contraindicated or clinically significant adverse effects are experienced; 4. Failure of TWO of the following unless contraindicated or clinically significant adverse effects are experienced: metoclopramide, prochlorperazine, lorazepam; 5. Dose does not exceed 15 mg/m2 per dose (6 doses per day) (Marinol), 6 mg/day (Cesamet), 12.6 mg/m2 per dose (6 doses per day) (Syndros).
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Therapeutic Options in Recurrent Glioblastoma – an Update
Impact Factor Therapeutic options in recurrent glioblastoma – an update Standards of care are not yet defined for patients with recurrent glioblastoma. In this critical review, Katharina Seystahl and colleagues summarise the available literature for patients with recurrent (progressive) glioblastoma treated with repeat surgery, re-irradiation, chemotherapy or immunotherapy approaches. This is an abridged version of K Seystahl et al (2016) Therapeutic options in recurrent glioblastoma –an update. Critical Reviews in Oncology/Hematology 99: 389-408. It was edited by Janet Fricker and is published with permission ©2016 Elsevier Ireland Ltd. doi:10.1016/j.critrevonc.2016.01.018 lioblastoma is a devastating temozolomide (TMZ) during and after bias, small sample sizes and disease disease with a median overall radiotherapy compared to radiotherapy heterogeneity. Gsurvival (OS) of 8.1 months for alone (12.1 months) (N Engl J the period 2000–2003 and 9.7 months Med 2005, 352:987–96). Promoter for 2005–2008 in population-based methylation of the O6-methylguanine- Diagnosis of progression and studies in the US (J Neurooncol 2012, DNA methyltransferase (MGMT) response 107:359–64). gene is a predictive biomarker for The current standard of care in benefit of TMZ in newly diagnosed The RANO (Response Assessment in newly diagnosed glioblastoma was glioblastoma (N Engl J Med 2005, Neuro-Oncology) criteria are considered established based on the trial of the 352:997–1003). Currently, no to be the most accepted approach for European Organisation for Research standard of care is established for diagnosis of progression and response and Treatment of Cancer (EORTC)/ recurrent or progressive glioblastoma in recurrent glioblastoma (J Clin Oncol National Cancer Institute of Canada (Lancet Oncol 2014, 15:e395–403).
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CYTOTOXIC and NON-CYTOTOXIC HAZARDOUS MEDICATIONS
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